Pieter Dorrestein

InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0751
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.Cornell University

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Reuse of Public Metabolomics Data
    NIH/NCI R03CA211211Sep 15, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Tools for rapid and accurate structure elucidation of natural products
    NIH/NIGMS R01GM107550Sep 5, 2013 - Apr 30, 2021
    Role: Principal Investigator
    Experiment based genome mining of ribosomal natural products
    NIH/NIGMS R01GM097509Apr 1, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Synapt ion mobility mass spectrometer
    NIH/NCRR S10RR029121Jun 15, 2011 - Jun 14, 2012
    Role: Principal Investigator
    The chemical and genetic basis of interspecies interactions
    NIH/NIAID R01AI095125Mar 7, 2011 - Feb 28, 2015
    Role: Principal Investigator
    Real-Time Imaging of metabolic Communication
    NIH/NIGMS R01GM094802Sep 1, 2010 - Aug 31, 2014
    Role: Principal Investigator
    New approaches to sequencing of complex peptides.
    NIH/NIGMS R01GM086283Sep 25, 2008 - Aug 31, 2012
    Role: Principal Investigator
    Enzymology of NRPS and PKS proteins by mass spectrometry
    NIH/NIGMS F32GM073323Mar 16, 2005 - Mar 15, 2008
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein P, Knight R, Benner C, Anstee QM, Karin M. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 Jul 04. PMID: 29973714.
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    2. Patin NV, Floros DJ, Hughes CC, Dorrestein P, Jensen PR. The role of inter-species interactions in Salinispora specialized metabolism. Microbiology. 2018 Jun 07. PMID: 29877785.
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    3. Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein P, Haddad GG. Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems. 2018 May-Jun; 3(3). PMID: 29896566.
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    4. Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J, Gonzalez A, Kosciolek T, McCall LI, McDonald D, Melnik AV, Morton JT, Navas J, Quinn RA, Sanders JG, Swafford AD, Thompson LR, Tripathi A, Xu ZZ, Zaneveld JR, Zhu Q, Caporaso JG, Dorrestein P. Best practices for analysing microbiomes. Nat Rev Microbiol. 2018 May 23. PMID: 29795328.
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    5. McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein P, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May-Jun; 3(3). PMID: 29795809.
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    6. da Silva RR, Wang M, Nothias LF, van der Hooft JJJ, Caraballo-Rodríguez AM, Fox E, Balunas MJ, Klassen JL, Lopes NP, Dorrestein P. Propagating annotations of molecular networks using in silico fragmentation. PLoS Comput Biol. 2018 Apr; 14(4):e1006089. PMID: 29668671.
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    7. McCall LI, Tripathi A, Vargas F, Knight R, Dorrestein P, Siqueira-Neto JL. Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome. PLoS Negl Trop Dis. 2018 Mar; 12(3):e0006344. PMID: 29529084.
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    8. Dorrestein P, Balskus EP. Chemical signaling at the eukaryotic/prokaryotic interface. Chem Soc Rev. 2018 Mar 05; 47(5):1572-1573. PMID: 29479607.
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    9. Nothias LF, Nothias-Esposito M, da Silva R, Wang M, Protsyuk I, Zhang Z, Sarvepalli A, Leyssen P, Touboul D, Costa J, Paolini J, Alexandrov T, Litaudon M, Dorrestein P. Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. J Nat Prod. 2018 Apr 27; 81(4):758-767. PMID: 29498278.
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    10. Kapono CA, Morton JT, Bouslimani A, Melnik AV, Orlinsky K, Knaan TL, Garg N, Vázquez-Baeza Y, Protsyuk I, Janssen S, Zhu Q, Alexandrov T, Smarr L, Knight R, Dorrestein P. Creating a 3D microbial and chemical snapshot of a human habitat. Sci Rep. 2018 Feb 27; 8(1):3669. PMID: 29487294.
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    11. Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein P, Greenberg EP, Lidstrom ME, Clardy J. Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. J Am Chem Soc. 2018 Feb 14; 140(6):2002-2006. PMID: 29361220.
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    12. Pla D, Petras D, Saviola AJ, Modahl CM, Sanz L, Pérez A, Juárez E, Frietze S, Dorrestein P, Mackessy SP, Calvete JJ. Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam. J Proteomics. 2018 Mar 01; 174:71-84. PMID: 29292096.
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    13. Hoffmann M, Auerbach D, Panter F, Hoffmann T, Dorrestein P, Müller R. Homospermidine Lipids: A Compound Class Specifically Formed during Fruiting Body Formation of Myxococcus xanthus DK1622. ACS Chem Biol. 2018 01 19; 13(1):273-280. PMID: 29185703.
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    14. Protsyuk I, Melnik AV, Nothias LF, Rappez L, Phapale P, Aksenov AA, Bouslimani A, Ryazanov S, Dorrestein P, Alexandrov T. 3D molecular cartography using LC-MS facilitated by Optimus and 'ili software. Nat Protoc. 2018 Jan; 13(1):134-154. PMID: 29266099.
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    15. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein P, Knight R, Benner C, Anstee QM, Karin M. Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. PMID: 29168501.
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    16. Scheubert K, Hufsky F, Petras D, Wang M, Nothias LF, Dührkop K, Bandeira N, Dorrestein P, Böcker S. Significance estimation for large scale metabolomics annotations by spectral matching. Nat Commun. 2017 Nov 14; 8(1):1494. PMID: 29133785.
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    17. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein P, Knight R, Benner C, Anstee QM, Karin M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. PMID: 29144460.
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    18. Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG. Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. PMID: 28678519.
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    19. Garg N, Wang M, Hyde E, da Silva RR, Melnik AV, Protsyuk I, Bouslimani A, Lim YW, Wong R, Humphrey G, Ackermann G, Spivey T, Brouha SS, Bandeira N, Lin GY, Rohwer F, Conrad DJ, Alexandrov T, Knight R, Dorrestein P. Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung. Cell Host Microbe. 2017 Nov 08; 22(5):705-716.e4. PMID: 29056429.
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    20. von Eckardstein L, Petras D, Dang T, Cociancich S, Sabri S, Grätz S, Kerwat D, Seidel M, Pesic A, Dorrestein P, Royer M, Weston JB, Süssmuth RD. Total Synthesis and Biological Assessment of Novel Albicidins Discovered by Mass Spectrometric Networking. Chemistry. 2017 Nov 02; 23(61):15316-15321. PMID: 28876492.
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    21. Hartmann AC, Petras D, Quinn RA, Protsyuk I, Archer FI, Ransome E, Williams GJ, Bailey BA, Vermeij MJA, Alexandrov T, Dorrestein P, Rohwer FL. Meta-mass shift chemical profiling of metabolomes from coral reefs. Proc Natl Acad Sci U S A. 2017 Oct 31; 114(44):11685-11690. PMID: 29078340.
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    22. Vázquez-Baeza Y, Callewaert C, Debelius J, Hyde E, Marotz C, Morton JT, Swafford A, Vrbanac A, Dorrestein P, Knight R. Impacts of the Human Gut Microbiome on Therapeutics. Annu Rev Pharmacol Toxicol. 2018 Jan 06; 58:253-270. PMID: 28968189.
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    23. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein P, McKerrow JH. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 Oct 03; 89(19):10414-10421. PMID: 28892370.
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    24. Nothias LF, Boutet-Mercey S, Cachet X, De La Torre E, Laboureur L, Gallard JF, Retailleau P, Brunelle A, Dorrestein P, Costa J, Bedoya LM, Roussi F, Leyssen P, Alcami J, Paolini J, Litaudon M, Touboul D. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata. J Nat Prod. 2017 Oct 27; 80(10):2620-2629. PMID: 28925702.
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    25. Ainsworth S, Petras D, Engmark M, Süssmuth RD, Whiteley G, Albulescu LO, Kazandjian TD, Wagstaff SC, Rowley P, Wüster W, Dorrestein P, Arias AS, Gutiérrez JM, Harrison RA, Casewell NR, Calvete JJ. The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms. J Proteomics. 2018 Feb 10; 172:173-189. PMID: 28843532.
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    26. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein P, Murray TF, Gerwick WH. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 Aug 25; 80(8):2328-2334. PMID: 28783331.
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    27. Hsu CC, Baker MW, Gaasterland T, Meehan MJ, Macagno ER, Dorrestein P. Top-Down Atmospheric Ionization Mass Spectrometry Microscopy Combined With Proteogenomics. Anal Chem. 2017 Aug 15; 89(16):8251-8258. PMID: 28692290.
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    28. Edlund A, Garg N, Mohimani H, Gurevich A, He X, Shi W, Dorrestein P, McLean JS. Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules. mSystems. 2017 Jul-Aug; 2(4). PMID: 28761934.
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    29. Boya P CA, Fernández-Marín H, Mejía LC, Spadafora C, Dorrestein P, Gutiérrez M. Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants. Sci Rep. 2017 Jul 17; 7(1):5604. PMID: 28717220.
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    30. Caraballo-Rodríguez AM, Dorrestein P, Pupo MT. Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides. Sci Rep. 2017 Jul 14; 7(1):5373. PMID: 28710400.
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    31. Melnik AV, da Silva RR, Hyde ER, Aksenov AA, Vargas F, Bouslimani A, Protsyuk I, Jarmusch AK, Tripathi A, Alexandrov T, Knight R, Dorrestein P. Coupling Targeted and Untargeted Mass Spectrometry for Metabolome-Microbiome-Wide Association Studies of Human Fecal Samples. Anal Chem. 2017 Jul 18; 89(14):7549-7559. PMID: 28628333.
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    32. Califf KJ, Schwarzberg-Lipson K, Garg N, Gibbons SM, Caporaso JG, Slots J, Cohen C, Dorrestein P, Kelley ST. Multi-omics Analysis of Periodontal Pocket Microbial Communities Pre- and Posttreatment. mSystems. 2017 May-Jun; 2(3). PMID: 28744486.
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    33. Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein P. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 2017 05 11; 6. PMID: 28492366.
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    34. Vrbanac A, Debelius JW, Jiang L, Morton JT, Dorrestein P, Knight R. An Elegan(t) Screen for Drug-Microbe Interactions. Cell Host Microbe. 2017 May 10; 21(5):555-556. PMID: 28494234.
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    35. Comstock WJ, Huh E, Weekes R, Watson C, Xu T, Dorrestein P, Quinn RA. The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections. J Vis Exp. 2017 05 08; (123). PMID: 28518116.
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    36. Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein P, Gerwick WH. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 May 26; 80(5):1514-1521. PMID: 28448144.
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    37. Chagas FO, Caraballo-Rodríguez AM, Dorrestein P, Pupo MT. Expanding the Chemical Repertoire of the Endophyte Streptomyces albospinus RLe7 Reveals Amphotericin B as an Inducer of a Fungal Phenotype. J Nat Prod. 2017 May 26; 80(5):1302-1309. PMID: 28375005.
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    38. Metcalf JL, Xu ZZ, Bouslimani A, Dorrestein P, Carter DO, Knight R. Microbiome Tools for Forensic Science. Trends Biotechnol. 2017 09; 35(9):814-823. PMID: 28366290.
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    39. Floros DJ, Petras D, Kapono CA, Melnik AV, Ling TJ, Knight R, Dorrestein P. Mass Spectrometry Based Molecular 3D-Cartography of Plant Metabolites. Front Plant Sci. 2017; 8:429. PMID: 28405197.
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    40. Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein P, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017 02 22; 9(378). PMID: 28228596.
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    41. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein P. Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2017 01 23; 2:17010. PMID: 28112718.
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    42. Morton JT, Sanders J, Quinn RA, McDonald D, Gonzalez A, Vázquez-Baeza Y, Navas-Molina JA, Song SJ, Metcalf JL, Hyde ER, Lladser M, Dorrestein P, Knight R. Balance Trees Reveal Microbial Niche Differentiation. mSystems. 2017 Jan-Feb; 2(1). PMID: 28144630.
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    43. Petras D, Jarmusch AK, Dorrestein P. From single cells to our planet-recent advances in using mass spectrometry for spatially resolved metabolomics. Curr Opin Chem Biol. 2017 Feb; 36:24-31. PMID: 28086192.
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    44. Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein P, Gerwick WH. Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J Nat Prod. 2017 Mar 24; 80(3):625-633. PMID: 28055219.
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    45. Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein P. Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen. mSystems. 2016 Nov-Dec; 1(6). PMID: 28028548.
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    46. Nothias LF, Knight R, Dorrestein P. Antibiotic discovery is a walk in the park. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14477-14479. PMID: 27940910.
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    47. Garg N, Luzzatto-Knaan T, Melnik AV, Caraballo-Rodríguez AM, Floros DJ, Petras D, Gregor R, Dorrestein P, Phelan VV. Natural products as mediators of disease. Nat Prod Rep. 2017 Feb 01; 34(2):194-219. PMID: 27874907.
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    48. Bouslimani A, Melnik AV, Xu Z, Amir A, da Silva RR, Wang M, Bandeira N, Alexandrov T, Knight R, Dorrestein P. Lifestyle chemistries from phones for individual profiling. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7645-E7654. PMID: 27849584.
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    49. Crüsemann M, O'Neill EC, Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein P, Moore BS. Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols. J Nat Prod. 2017 Mar 24; 80(3):588-597. PMID: 28335604.
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    50. Quinn RA, Nothias LF, Vining O, Meehan M, Esquenazi E, Dorrestein P. Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy. Trends Pharmacol Sci. 2017 02; 38(2):143-154. PMID: 27842887.
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    51. Wohlgemuth G, Mehta SS, Mejia RF, Neumann S, Pedrosa D, Pluskal T, Schymanski EL, Willighagen EL, Wilson M, Wishart DS, Arita M, Dorrestein P, Bandeira N, Wang M, Schulze T, Salek RM, Steinbeck C, Nainala VC, Mistrik R, Nishioka T, Fiehn O. SPLASH, a hashed identifier for mass spectra. Nat Biotechnol. 2016 Nov 08; 34(11):1099-1101. PMID: 27824832.
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    52. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore BS, Medema MH, Dorrestein P. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2016 10 31; 2:16197. PMID: 27798598.
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    53. Mohimani H, Gurevich A, Mikheenko A, Garg N, Nothias LF, Ninomiya A, Takada K, Dorrestein P, Pevzner PA. Dereplication of peptidic natural products through database search of mass spectra. Nat Chem Biol. 2017 Jan; 13(1):30-37. PMID: 27820803.
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    54. Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook V, Garg N, Hoffner N, Jiang Y, Kapono CA, Koester I, Knight R, Leber CA, Ling TJ, Luzzatto-Knaan T, McCall LI, McGrath AP, Meehan MJ, Merritt JK, Mills RH, Morton J, Podvin S, Protsyuk I, Purdy T, Satterfield K, Searles S, Shah S, Shires S, Steffen D, White M, Todoric J, Tuttle R, Wojnicz A, Sapp V, Vargas F, Yang J, Zhang C, Dorrestein P. Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem. 2016 Nov 15; 88(22):10775-10784. PMID: 27732780.
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    55. Mir Mohseni M, Höver T, Barra L, Kaiser M, Dorrestein P, Dickschat JS, Schäberle TF. Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging. Angew Chem Int Ed Engl. 2016 Oct 17; 55(43):13611-13614. PMID: 27667141.
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    56. Quinn RA, Vermeij MJ, Hartmann AC, d'Auriac IG, Benler S, Haas A, Quistad SD, Lim YW, Little M, Sandin S, Smith JE, Dorrestein P, Rohwer F. Correction to 'Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence'. Proc Biol Sci. 2016 Aug 31; 283(1837). PMID: 27559065; PMCID: PMC5013801.
    57. Quinn RA, Lim YW, Mak TD, Whiteson K, Furlan M, Conrad D, Rohwer F, Dorrestein P. Metabolomics of pulmonary exacerbations reveals the personalized nature of cystic fibrosis disease. PeerJ. 2016; 4:e2174. PMID: 27602256; PMCID: PMC4991883.
    58. Floros DJ, Jensen PR, Dorrestein P, Koyama N. A metabolomics guided exploration of marine natural product chemical space. Metabolomics. 2016 Sep; 12(9). PMID: 28819353.
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    59. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein P, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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    60. Gilbert JA, Quinn RA, Debelius J, Xu ZZ, Morton J, Garg N, Jansson JK, Dorrestein P, Knight R. Microbiome-wide association studies link dynamic microbial consortia to disease. Nature. 2016 07 07; 535(7610):94-103. PMID: 27383984.
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    61. Deveau A, Gross H, Palin B, Mehnaz S, Schnepf M, Leblond P, Dorrestein P, Aigle B. Role of secondary metabolites in the interaction between Pseudomonas fluorescens and soil microorganisms under iron-limited conditions. FEMS Microbiol Ecol. 2016 08; 92(8). PMID: 27199346.
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    62. Dorrestein P, Gallo RL, Knight R. Microbial Skin Inhabitants: Friends Forever. Cell. 2016 May 05; 165(4):771-2. PMID: 27153488.
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    63. Maansson M, Vynne NG, Klitgaard A, Nybo JL, Melchiorsen J, Nguyen DD, Sanchez LM, Ziemert N, Dorrestein P, Andersen MR, Gram L. An Integrated Metabolomic and Genomic Mining Workflow To Uncover the Biosynthetic Potential of Bacteria. mSystems. 2016 May-Jun; 1(3). PMID: 27822535.
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    67. Moran MA, Kujawinski EB, Stubbins A, Fatland R, Aluwihare LI, Buchan A, Crump BC, Dorrestein P, Dyhrman ST, Hess NJ, Howe B, Longnecker K, Medeiros PM, Niggemann J, Obernosterer I, Repeta DJ, Waldbauer JR. Deciphering ocean carbon in a changing world. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3143-51. PMID: 26951682; PMCID: PMC4812754.
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    71. Biteen JS, Blainey PC, Cardon ZG, Chun M, Church GM, Dorrestein P, Fraser SE, Gilbert JA, Jansson JK, Knight R, Miller JF, Ozcan A, Prather KA, Quake SR, Ruby EG, Silver PA, Taha S, van den Engh G, Weiss PS, Wong GC, Wright AT, Young TD. Tools for the Microbiome: Nano and Beyond. ACS Nano. 2016 Jan 26; 10(1):6-37. PMID: 26695070.
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    72. Frydenlund Michelsen C, Hossein Khademi SM, Krogh Johansen H, Ingmer H, Dorrestein P, Jelsbak L. Evolution of metabolic divergence in Pseudomonas aeruginosa during long-term infection facilitates a proto-cooperative interspecies interaction. ISME J. 2016 06; 10(6):1323-36. PMID: 26684729.
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    76. Rateb ME, Zhai Y, Ehrner E, Rath CM, Wang X, Tabudravu J, Ebel R, Bibb M, Kyeremeh K, Dorrestein P, Hong K, Jaspars M, Deng H. Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate. Org Biomol Chem. 2015 Oct 07; 13(37):9585-92. PMID: 26256511.
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    80. Liu Y, Rzeszutek E, van der Voort M, Wu CH, Thoen E, Skaar I, Bulone V, Dorrestein P, Raaijmakers JM, de Bruijn I. Diversity of Aquatic Pseudomonas Species and Their Activity against the Fish Pathogenic Oomycete Saprolegnia. PLoS One. 2015; 10(8):e0136241. PMID: 26317985; PMCID: PMC4552890.
    81. Hoffmann T, Dorrestein P. Homogeneous matrix deposition on dried agar for MALDI imaging mass spectrometry of microbial cultures. J Am Soc Mass Spectrom. 2015 Nov; 26(11):1959-62. PMID: 26297185.
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    84. Patin NV, Duncan KR, Dorrestein P, Jensen PR. Competitive strategies differentiate closely related species of marine actinobacteria. ISME J. 2016 Feb; 10(2):478-90. PMID: 26241505; PMCID: PMC4737938 [Available on 02/01/17].
    85. Liaw CC, Chen PC, Shih CJ, Tseng SP, Lai YM, Hsu CH, Dorrestein P, Yang YL. Vitroprocines, new antibiotics against Acinetobacter baumannii, discovered from marine Vibrio sp. QWI-06 using mass-spectrometry-based metabolomics approach. Sci Rep. 2015 Aug 04; 5:12856. PMID: 26238555; PMCID: PMC4523872.
    86. Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein P, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. PLoS One. 2015; 10(7):e0133297. PMID: 26222584; PMCID: PMC4519256.
    87. Briand E, Bormans M, Gugger M, Dorrestein P, Gerwick WH. Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions. Environ Microbiol. 2016 Feb; 18(2):384-400. PMID: 25980449.
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    89. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein P, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. PMID: 26149623; PMCID: PMC4681511.
    90. Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein P, Palfey B, Moore BS. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. J Am Chem Soc. 2015 Jul 01; 137(25):8078-85. PMID: 26067765; PMCID: PMC4720136.
    91. Gao WW, Xiao RQ, Peng BL, Xu HT, Shen HF, Huang MF, Shi TT, Yi J, Zhang WJ, Wu XN, Gao X, Lin XZ, Dorrestein P, Rosenfeld MG, Liu W. Arginine methylation of HSP70 regulates retinoid acid-mediated RARß2 gene activation. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):E3327-36. PMID: 26080448; PMCID: PMC4491752.
    92. Edlund A, Yang Y, Yooseph S, Hall AP, Nguyen DD, Dorrestein P, Nelson KE, He X, Lux R, Shi W, McLean JS. Meta-omics uncover temporal regulation of pathways across oral microbiome genera during in vitro sugar metabolism. ISME J. 2015 Dec; 9(12):2605-19. PMID: 26023872; PMCID: PMC4817640.
    93. Song J, Liu X, Rao TS, Chang L, Meehan MJ, Blevitt JM, Wu J, Dorrestein P, Milla ME. Phenotyping drug polypharmacology via eicosanoid profiling of blood. J Lipid Res. 2015 Aug; 56(8):1492-500. PMID: 26022804; PMCID: PMC4513990.
    94. Oetjen J, Veselkov K, Watrous J, McKenzie JS, Becker M, Hauberg-Lotte L, Kobarg JH, Strittmatter N, Mróz AK, Hoffmann F, Trede D, Palmer A, Schiffler S, Steinhorst K, Aichler M, Goldin R, Guntinas-Lichius O, von Eggeling F, Thiele H, Maedler K, Walch A, Maass P, Dorrestein P, Takats Z, Alexandrov T. Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry. Gigascience. 2015; 4:20. PMID: 25941567; PMCID: PMC4418095.
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    98. Mascuch SJ, Moree WJ, Hsu CC, Turner GG, Cheng TL, Blehert DS, Kilpatrick AM, Frick WF, Meehan MJ, Dorrestein P, Gerwick L. Direct detection of fungal siderophores on bats with white-nose syndrome via fluorescence microscopy-guided ambient ionization mass spectrometry. PLoS One. 2015; 10(3):e0119668. PMID: 25781976; PMCID: PMC4364562.
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    101. Bleich R, Watrous JD, Dorrestein P, Bowers AA, Shank EA. Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3086-91. PMID: 25713360; PMCID: PMC4364203.
    102. Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein P, Gerwick L, Gerwick WH. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27; 78(3):493-9. PMID: 25668560.
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    105. Sumner LW, Styczynski M, McLean J, Fiehn O, Jander G, Liao J, Sumner S, Britz-McKibbin P, Welti R, Jones AD, Dorrestein P, Bearden D, Kaddurah-Daouk R. Introducing the USA Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM-NET). Metabolomics. 2015 Feb; 11(1):3-5. PMID: 28018159.
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    107. Sharon G, Garg N, Debelius J, Knight R, Dorrestein P, Mazmanian SK. Specialized metabolites from the microbiome in health and disease. Cell Metab. 2014 Nov 04; 20(5):719-730. PMID: 25440054.
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    114. Dorrestein P, Mazmanian SK, Knight R. Finding the missing links among metabolites, microbes, and the host. Immunity. 2014 Jun 19; 40(6):824-32. PMID: 24950202; PMCID: PMC4503329.
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    121. Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein P. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. J Bacteriol. 2014 May; 196(9):1683-93. PMID: 24532776; PMCID: PMC3993319.
    122. Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein P, Moore BS. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1957-62. PMID: 24449899; PMCID: PMC3918841.
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    129. Davis J, Fricke WF, Hamann MT, Esquenazi E, Dorrestein P, Hill RT. Characterization of the bacterial community of the chemically defended Hawaiian sacoglossan Elysia rufescens. Appl Environ Microbiol. 2013 Nov; 79(22):7073-81. PMID: 24014539; PMCID: PMC3811551.
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    132. Soriano EV, Zhang Y, Colabroy KL, Sanders JM, Settembre EC, Dorrestein P, Begley TP, Ealick SE. Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallogr D Biol Crystallogr. 2013 Sep; 69(Pt 9):1685-96. PMID: 23999292; PMCID: PMC3760129.
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    135. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore BS, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein P. MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2611-20. PMID: 23798442; PMCID: PMC3710860.
    136. Pérez Morales TG, Ho TD, Liu WT, Dorrestein P, Ellermeier CD. Production of the cannibalism toxin SDP is a multistep process that requires SdpA and SdpB. J Bacteriol. 2013 Jul; 195(14):3244-51. PMID: 23687264; PMCID: PMC3697648.
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    144. Young TS, Dorrestein P, Walsh CT. Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol. 2012 Dec 21; 19(12):1600-10. PMID: 23261603; PMCID: PMC3530156.
    145. Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein P, Milla ME. A highly efficient, high-throughput lipidomics platform for the quantitative detection of eicosanoids in human whole blood. Anal Biochem. 2013 Feb 15; 433(2):181-8. PMID: 23103340.
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    152. Hoefler BC, Gorzelnik KV, Yang JY, Hendricks N, Dorrestein P, Straight PD. Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13082-7. PMID: 22826229; PMCID: PMC3420176.
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    156. Xu Y, Kersten RD, Nam SJ, Lu L, Al-Suwailem AM, Zheng H, Fenical W, Dorrestein P, Moore BS, Qian PY. Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc. 2012 May 23; 134(20):8625-32. PMID: 22458477; PMCID: PMC3401512.
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    163. Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein P, Russell DH, Ealick SE, Begley TP. Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 2011 Oct 26; 478(7370):542-6. PMID: 22031445; PMCID: PMC3205460.
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    166. Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein P, Pevzner PA. Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res. 2011 Oct 07; 10(10):4505-12. PMID: 21851130; PMCID: PMC3242011.
    167. Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein P, Minshull J, Khosla C. Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chem Biol. 2011 Aug 26; 18(8):1021-31. PMID: 21867917; PMCID: PMC3172819.
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    186. Meehan MJ, Xie X, Zhao X, Xu W, Tang Y, Dorrestein P. FT-ICR-MS characterization of intermediates in the biosynthesis of the a-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. Biochemistry. 2011 Jan 18; 50(2):287-99. PMID: 21069965; PMCID: PMC3085095.
    187. Meier JL, Patel AD, Niessen S, Meehan M, Kersten R, Yang JY, Rothmann M, Cravatt BF, Dorrestein P, Burkart MD, Bafna V. Practical 4'-phosphopantetheine active site discovery from proteomic samples. J Proteome Res. 2011 Jan 07; 10(1):320-9. PMID: 21067235; PMCID: PMC3042426.
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    189. Liu X, Inbar Y, Dorrestein P, Wynne C, Edwards N, Souda P, Whitelegge JP, Bafna V, Pevzner PA. Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach. Mol Cell Proteomics. 2010 Dec; 9(12):2772-82. PMID: 20855543; PMCID: PMC3101958.
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    193. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein P, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12. PMID: 20622854; PMCID: PMC3059551.
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    197. Zhou H, Qiao K, Gao Z, Meehan MJ, Li JW, Zhao X, Dorrestein P, Vederas JC, Tang Y. Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis. J Am Chem Soc. 2010 Apr 07; 132(13):4530-1. PMID: 20222707; PMCID: PMC2861853.
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    207. Xie X, Meehan MJ, Xu W, Dorrestein P, Tang Y. Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc. 2009 Jun 24; 131(24):8388-9. PMID: 19530726; PMCID: PMC2878198.
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    210. O'Hayre M, Salanga CL, Dorrestein P, Handel TM. Phosphoproteomic analysis of chemokine signaling networks. Methods Enzymol. 2009; 460:331-46. PMID: 19446733.
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    220. Calderone CT, Iwig DF, Dorrestein P, Kelleher NL, Walsh CT. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol. 2007 Jul; 14(7):835-46. PMID: 17656320; PMCID: PMC2084360.
    221. Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein P, Moore BS. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem. 2007 Jun 01; 282(22):16362-8. PMID: 17392281.
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    222. Yin J, Straight PD, Hrvatin S, Dorrestein P, Bumpus SB, Jao C, Kelleher NL, Kolter R, Walsh CT. Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chem Biol. 2007 Mar; 14(3):303-12. PMID: 17379145.
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    223. Dorrestein P, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 2006 Oct 24; 45(42):12756-66. PMID: 17042494; PMCID: PMC2518290.
    224. Garneau-Tsodikova S, Dorrestein P, Kelleher NL, Walsh CT. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. J Am Chem Soc. 2006 Oct 04; 128(39):12600-1. PMID: 17002325.
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    225. Dorrestein P, Kelleher NL. Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Nat Prod Rep. 2006 Dec; 23(6):893-918. PMID: 17119639.
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    226. Dorrestein P, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL. The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. J Am Chem Soc. 2006 Aug 16; 128(32):10386-7. PMID: 16895402.
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    227. Van Lanen SG, Lin S, Dorrestein P, Kelleher NL, Shen B. Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. J Biol Chem. 2006 Oct 06; 281(40):29633-40. PMID: 16887797.
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    228. Calderone CT, Kowtoniuk WE, Kelleher NL, Walsh CT, Dorrestein P. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):8977-82. PMID: 16757561; PMCID: PMC1482551.
    229. Hicks LM, Mazur MT, Miller LM, Dorrestein P, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem. 2006 Jun; 7(6):904-7. PMID: 16642537.
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    230. Howarth M, Chinnapen DJ, Gerrow K, Dorrestein P, Grandy MR, Kelleher NL, El-Husseini A, Ting AY. A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods. 2006 Apr; 3(4):267-73. PMID: 16554831; PMCID: PMC2576293.
    231. Dorrestein P, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 2006 Feb 14; 45(6):1537-46. PMID: 16460000; PMCID: PMC2565507.
    232. Aron ZD, Dorrestein P, Blackhall JR, Kelleher NL, Walsh CT. Characterization of a new tailoring domain in polyketide biogenesis: the amine transferase domain of MycA in the mycosubtilin gene cluster. J Am Chem Soc. 2005 Nov 02; 127(43):14986-7. PMID: 16248612.
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    233. Dorrestein P, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13843-8. PMID: 16162666; PMCID: PMC1236592.
    234. Burns KE, Baumgart S, Dorrestein P, Zhai H, McLafferty FW, Begley TP. Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. J Am Chem Soc. 2005 Aug 24; 127(33):11602-3. PMID: 16104727; PMCID: PMC2536522.
    235. Van Lanen SG, Dorrestein P, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. J Am Chem Soc. 2005 Aug 24; 127(33):11594-5. PMID: 16104723.
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    236. Zhai H, Dorrestein P, Chatterjee A, Begley TP, McLafferty FW. Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. J Am Soc Mass Spectrom. 2005 Jul; 16(7):1052-9. PMID: 15914018.
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    237. Dorrestein P, Begley TP. Oxidative cascades: a facile biosynthetic strategy for the assembly of complex molecules. Bioorg Chem. 2005 Jun; 33(3):136-48. PMID: 15888307.
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    238. Garneau S, Dorrestein P, Kelleher NL, Walsh CT. Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis. Biochemistry. 2005 Mar 01; 44(8):2770-80. PMID: 15723521.
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    239. Dorrestein P, Zhai H, McLafferty FW, Begley TP. The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS. Chem Biol. 2004 Oct; 11(10):1373-81. PMID: 15489164.
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    240. Settembre EC, Dorrestein P, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE. Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry. 2004 Sep 21; 43(37):11647-57. PMID: 15362849.
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    241. Dorrestein P, Zhai H, Taylor SV, McLafferty FW, Begley TP. The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. J Am Chem Soc. 2004 Mar 17; 126(10):3091-6. PMID: 15012138.
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    242. Park JH, Dorrestein P, Zhai H, Kinsland C, McLafferty FW, Begley TP. Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. 2003 Oct 28; 42(42):12430-8. PMID: 14567704.
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    243. Kurnasov O, Jablonski L, Polanuyer B, Dorrestein P, Begley T, Osterman A. Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS Microbiol Lett. 2003 Oct 24; 227(2):219-27. PMID: 14592712.
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    244. Maggio-Hall LA, Dorrestein P, Escalante-Semerena JC, Begley TP. Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade. Org Lett. 2003 Jun 26; 5(13):2211-3. PMID: 12816411.
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    245. Dorrestein P, Poole K, Begley TP. Formation of the chromophore of the pyoverdine siderophores by an oxidative cascade. Org Lett. 2003 Jun 26; 5(13):2215-7. PMID: 12816412.
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    246. Settembre EC, Dorrestein P, Park JH, Augustine AM, Begley TP, Ealick SE. Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry. 2003 Mar 18; 42(10):2971-81. PMID: 12627963.
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    247. Anand R, Dorrestein P, Kinsland C, Begley TP, Ealick SE. Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry. 2002 Jun 18; 41(24):7659-69. PMID: 12056897.
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    248. Begley TP, Kinsland C, Mehl RA, Osterman A, Dorrestein P. The biosynthesis of nicotinamide adenine dinucleotides in bacteria. Vitam Horm. 2001; 61:103-19. PMID: 11153263.
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