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Anthony O'Donoghue

Title(s)Assistant Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0755
La Jolla CA 92093
Phone8/5-34--5360
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    Collapse Biography 
    Collapse Education and Training
    University of California San FranciscoAssociate Specialist2015Pharmaceutical Chemistry
    University of California San FranciscoPost-Doctoral Training2011Pharmaceutical Chemistry
    National University of Ireland, GalwayPh.D2005Biochemistry
    National University of Ireland, GalwayB.S.2000Biochemistry
    Cork Institute of Technology, IrelandNational Diploma1998Cell & Molecular Biology
    Collapse Awards and Honors
    NIH/NIBIB2019  - 2022Trailblazer Awardee
    International Proteolysis Society2019  - 2021President
    International Proteolysis Society2017  - 2019Member of Council - Treasurer
    Future Science2013  - 2013Bioanalysis Young Investigator Award
    National University of Ireland, Galway2002  - 2003UC Education Abroad Scholarship

    Collapse Overview 
    Collapse Overview
    My laboratory interests lie in the detection and characterization of proteolytic enzymes that are involved in disease. In particular, we are interested in understanding the role of peptidases/proteases at host-pathogen and tumor-stroma interfaces. Our research utilizes a mass spectrometry based platform technology to uncover the global proteolytic activity in complex biological samples such as the secretions of cancer cells and infectious organisms. Our workflow also includes in-depth proteomic analysis to identify the enzymes. Knowledge of which peptidases are functionally active in diseased tissue and not active in healthy tissue allow us to 1) develop peptidase inhibitors to shut down the function, 2) generate peptidase-activated imaging agents to locate the disease or 3) develop peptidase-activated drugs to aid in the delivery of toxic compounds to the site of disease. Using this technology, we have uncovered novel proteolytic activities in gastric juice, pancreatic cyst fluid, serum and neutrophil extracts. In addition our group is highly collaborative and we routinely generate substrate specificity profiles of endo- and exo-peptidases that have been isolated from diverse organisms that includes ticks, crustaceans and parasitic worms.

    Collapse Research 
    Collapse Research Activities and Funding
    Quantification of Proteolytic Activity in Human Milk using Mass Spectrometry
    MOMI Seeds Pilot Grant MOMI 2020Jan 1, 2020 - Jan 1, 2021
    Role: Principal Investigator
    Point-of-Care Quantitation of Sputum Neutrophil Elastase Activity in Chronic Airway Disease
    NIH/NIBIB R21EB028485Jul 1, 2019 - Mar 31, 2022
    Role: Principal Investigator
    Selective proteasome inhibitors for trichomoniasis
    NIH/NIAID R21AI146387Jul 1, 2019 - Jun 30, 2021
    Role: Co-Principal Investigator
    Global identification of novel protease activity for Coccidioides, the Valley fever pathogen
    NIH/NIAID R21AI140020Jun 22, 2018 - May 31, 2020
    Role: Sub-award PI
    Exploring the proteasome as a new drug target to treat schistosomiasis
    NIH R21AI133393Jun 23, 2017 - May 31, 2019
    Role: Principal Investigator
    Global Profiling of Extracellular Protease Activity from Lung Cancer Cells
    American Cancer Society Institute Research Grant Dec 15, 2016 - Dec 14, 2016
    Role: Principal Investigator
    Global analysis of age-related changes to peptide and protease signaling using patient-derived, age-preserved induced neurons
    UC San Diego Center for Healthy Aging Oct 1, 2016 - Sep 30, 2017
    Role: Principal Investigator
    Rapid Point-of-Care Detection of Candidemia in Serum
    UC San Diego CTRI Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Science. 2020 Sep 25; 369(6511):1644-1649. Wendt G, Zhao L, Chen R, Liu C, O'Donoghue AJ, Caffrey CR, Reese ML, Collins JJ. PMID: 32973030.
      View in: PubMed   Mentions:    Fields:    
    2. High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. Molecules. 2020 Sep 06; 25(18). Maffioli E, Jiang Z, Nonnis S, Negri A, Romeo V, Lietz CB, Hook V, Ristagno G, Baselli G, Kistler EB, Aletti F, O'Donoghue AJ, Tedeschi G. PMID: 32899982.
      View in: PubMed   Mentions:    Fields:    
    3. Giant magnetoresistive biosensors for real-time quantitative detection of protease activity. Sci Rep. 2020 May 14; 10(1):7941. Adem S, Jain S, Sveiven M, Zhou X, O'Donoghue AJ, Hall DA. PMID: 32409675.
      View in: PubMed   Mentions:    Fields:    
    4. Engineering of multiple trypsin/chymotrypsin sites in Cry3A to enhance its activity against Monochamus alternatus Hope larvae. Pest Manag Sci. 2020 Apr 22. Guo Y, Wang Y, O'Donoghue AJ, Jiang Z, Carballar-Lejarazú R, Liang G, Hu X, Wang R, Xu L, Guan X, Zhang F, Wu S. PMID: 32323409.
      View in: PubMed   Mentions:    Fields:    
    5. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 Aug; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689.
      View in: PubMed   Mentions:    Fields:    
    6. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. PMID: 32295833.
      View in: PubMed   Mentions:    Fields:    
    7. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Front Cell Infect Microbiol. 2020; 10:66. Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. PMID: 32175287.
      View in: PubMed   Mentions: 1     Fields:    
    8. Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. ACS Chem Biol. 2020 03 20; 15(3):751-757. Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. PMID: 31935054.
      View in: PubMed   Mentions: 2     Fields:    
    9. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 11 26; 400(12):1629-1638. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 31256057.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant. ACS Omega. 2019 Oct 15; 4(16):16999-17008. Meewan I, Zhang X, Roy S, Ballatore C, O'Donoghue AJ, Schooley RT, Abagyan R. PMID: 31646247.
      View in: PubMed   Mentions:
    12. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). Parasit Vectors. 2019 Jul 30; 12(1):383. Chaimon S, Limpanont Y, Reamtong O, Ampawong S, Phuphisut O, Chusongsang P, Ruangsittichai J, Boonyuen U, Watthanakulpanich D, O'Donoghue AJ, Caffrey CR, Adisakwattana P. PMID: 31362766.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    14. Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome. Microbiome. 2019 02 13; 7(1):23. Quinn RA, Adem S, Mills RH, Comstock W, DeRight Goldasich L, Humphrey G, Aksenov AA, Melnik AV, da Silva R, Ackermann G, Bandeira N, Gonzalez DJ, Conrad D, O'Donoghue AJ, Knight R, Dorrestein PC. PMID: 30760325.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry. Mol Cell Proteomics. 2019 05; 18(5):968-981. Lapek JD, Jiang Z, Wozniak JM, Arutyunova E, Wang SC, Lemieux MJ, Gonzalez DJ, O'Donoghue AJ. PMID: 30705125.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. J Med Chem. 2019 01 24; 62(2):480-490. Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW. PMID: 30571119.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    17. An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases. Biol Chem. 2018 11 27; 399(12):1389-1397. Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O'Donoghue AJ, Lemieux MJ. PMID: 30044760.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome. Biol Chem. 2018 11 27; 399(12):1375-1388. Beekman C, Jiang Z, Suzuki BM, Palmer JM, Lindner DL, O'Donoghue AJ, Knudsen GM, Bennett RJ. PMID: 30367778.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    19. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. PLoS Negl Trop Dis. 2018 10; 12(10):e0006923. Rebello KM, McKerrow JH, Mota EM, O'Donoghue AJ, Neves-Ferreira AGC. PMID: 30379807.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    20. A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro. ACS Chem Biol. 2018 09 21; 13(9):2513-2521. Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW. PMID: 30085657.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    21. Validation of Babesia proteasome as a drug target. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):394-402. Jalovecka M, Hartmann D, Miyamoto Y, Eckmann L, Hajdusek O, O'Donoghue AJ, Sojka D. PMID: 30103207.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 04; 12(4):e0006446. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M. PMID: 29677188.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
      View in: PubMed   Mentions:
    24. Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 05; 29(5):935-947. Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. PMID: 29556927.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    25. Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation. J Invest Dermatol. 2018 05; 138(5):1137-1145. Li H, Goh BN, Teh WK, Jiang Z, Goh JPZ, Goh A, Wu G, Hoon SS, Raida M, Camattari A, Yang L, O'Donoghue AJ, Dawson TL. PMID: 29246799.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. Global substrate specificity profiling of post-translational modifying enzymes. Protein Sci. 2018 03; 27(3):584-594. Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS. PMID: 29168252.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. Elife. 2017 11 28; 6. Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS. PMID: 29182146.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    28. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 08 10; 60(15):6721-6732. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. PMID: 28696697.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. ACS Chem Biol. 2017 06 16; 12(6):1556-1565. Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. PMID: 28414448.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    31. Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs. Anal Chem. 2017 04 18; 89(8):4550-4558. Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS. PMID: 28322550.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    32. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 05; 284(10):1503-1517. Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ. PMID: 28122162.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLoS Pathog. 2016 Dec; 12(12):e1006051. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. PMID: 27977806.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    34. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors. Biol Chem. 2016 09 01; 397(9):871-81. O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS. PMID: 27149201.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. IL-1ß is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016 Aug; 1(2). LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. PMID: 28331908.
      View in: PubMed   Mentions: 9     Fields:    
    36. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    37. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. ACS Infect Dis. 2016 11 11; 2(11):807-815. Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. PMID: 27739665.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500.
      View in: PubMed   Mentions: 18     Fields:    
    39. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 2016 Feb 11; 530(7589):233-6. Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. PMID: 26863983.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    40. Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion. Mar Biotechnol (NY). 2016 Apr; 18(2):201-14. Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F. PMID: 26613762.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. PMID: 26409899.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7478-83. O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. PMID: 25944934.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    43. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor. Biochem J. 2015 Jan 01; 465(1):163-73. Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. PMID: 25279554.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One. 2013; 8(9):e75141. O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. PMID: 24073241.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    45. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PMID: 23875031.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    46. Bioanalysis Young Investigator Award 2013. Bioanalysis. 2013 Jul; 5(13):1617-21. O'Donoghue AJ, Hua S, Meyer B, Ros A. PMID: 23822125.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. J Biol Chem. 2013 May 03; 288(18):12489-99. Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. PMID: 23504313.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    48. Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov; 9(11):1095-100. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. PMID: 23023596.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    49. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. PMID: 22539347.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    50. Global landscape of HIV-human protein complexes. Nature. 2011 Dec 21; 481(7381):365-70. Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. PMID: 22190034.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansCells
    51. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology (Reading). 2009 Nov; 155(Pt 11):3673-3682. Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. PMID: 19556294.
      View in: PubMed   Mentions:
    52. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. PMID: 18701454.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    53. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. J Biol Chem. 2008 Oct 24; 283(43):29186-95. O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. PMID: 18687686.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    54. Cloning and characterization of osteoclast precursors from the RAW264.7 cell line. In Vitro Cell Dev Biol Anim. 2006 Jul-Aug; 42(7):182-8. Cuetara BL, Crotti TN, O'Donoghue AJ, McHugh KP. PMID: 16948499.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
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