Anthony O'donoghue

Title(s)Associate Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-5695-0409 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California San FranciscoAssociate Specialist2015Pharmaceutical Chemistry
    University of California San FranciscoPost-Doctoral Training2011Pharmaceutical Chemistry
    National University of Ireland, GalwayPh.D2005Biochemistry
    National University of Ireland, GalwayB.S.2000Biochemistry
    Cork Institute of Technology, IrelandNational Diploma1998Cell & Molecular Biology
    Collapse Awards and Honors
    NIH/NIBIB2019  - 2022Trailblazer Awardee
    International Proteolysis Society2019  - 2023President
    International Proteolysis Society2017  - 2019Member of Council - Treasurer
    Future Science2013  - 2013Bioanalysis Young Investigator Award
    National University of Ireland, Galway2002  - 2003UC Education Abroad Scholarship

    Collapse Overview 
    Collapse Overview
    My laboratory interests lie in the detection and characterization of proteolytic enzymes that are involved in disease. In particular, we are interested in understanding the role of peptidases/proteases at host-pathogen and tumor-stroma interfaces. Our research utilizes a mass spectrometry based platform technology to uncover the global proteolytic activity in complex biological samples such as the secretions of cancer cells and infectious organisms. Our workflow also includes in-depth proteomic analysis to identify the enzymes. Knowledge of which peptidases are functionally active in diseased tissue and not active in healthy tissue allow us to 1) develop peptidase inhibitors to shut down the function, 2) generate peptidase-activated imaging agents to locate the disease or 3) develop peptidase-activated drugs to aid in the delivery of toxic compounds to the site of disease. Using this technology, we have uncovered novel proteolytic activities in gastric juice, pancreatic cyst fluid, serum and neutrophil extracts. In addition our group is highly collaborative and we routinely generate substrate specificity profiles of endo- and exo-peptidases that have been isolated from diverse organisms that includes ticks, crustaceans and parasitic worms.

    Collapse Research 
    Collapse Research Activities and Funding
    Tumor-specific drug activation by pericellular proteases
    NCI R21CA256460Feb 1, 2022 - Jan 31, 2023
    Role: Principal Investigator
    Proteasome inhibitors against mucosal protozoan pathogens
    NIH R01AI158612Sep 22, 2021 - Aug 31, 2026
    Role: Co-Principal Investigator
    Quantification of Proteolytic Activity in Human Milk using Mass Spectrometry
    MOMI Seeds Pilot Grant MOMI 2020Jan 1, 2020 - Jan 1, 2021
    Role: Principal Investigator
    Point-of-Care Quantitation of Sputum Neutrophil Elastase Activity in Chronic Airway Disease
    NIH R21EB028485Jul 1, 2019 - Mar 31, 2022
    Role: Principal Investigator
    Selective proteasome inhibitors for trichomoniasis
    NIH R21AI146387Jul 1, 2019 - Jun 30, 2021
    Role: Co-Principal Investigator
    Global identification of novel protease activity for Coccidioides, the Valley fever pathogen
    NIH/NIAID R21AI140020Jun 22, 2018 - May 31, 2020
    Role: Sub-award PI
    Exploring the proteasome as a new drug target to treat schistosomiasis
    NIH R21AI133393Jun 23, 2017 - May 31, 2019
    Role: Principal Investigator
    Global Profiling of Extracellular Protease Activity from Lung Cancer Cells
    American Cancer Society Institute Research Grant Dec 15, 2016 - Dec 14, 2016
    Role: Principal Investigator
    Global analysis of age-related changes to peptide and protease signaling using patient-derived, age-preserved induced neurons
    UC San Diego Center for Healthy Aging Oct 1, 2016 - Sep 30, 2017
    Role: Principal Investigator
    Rapid Point-of-Care Detection of Candidemia in Serum
    UC San Diego CTRI Apr 1, 2016 - Mar 31, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Characterization of glutamate carboxypeptidase 2 orthologs in trematodes. Parasit Vectors. 2022 Dec 20; 15(1):480. Jedlickova L, Peterkova K, Boateng EM, Ulrychova L, Vacek V, Kutil Z, Jiang Z, Novakova Z, Snajdr I, Kim J, O'Donoghue AJ, Barinka C, Dvorak J. PMID: 36539882; PMCID: PMC9768917.
      View in: PubMed   Mentions:
    2. The human pathobiont Malassezia furfur secreted protease Mfsap1 regulates cell dispersal and exacerbates skin inflammation. Proc Natl Acad Sci U S A. 2022 Dec 06; 119(49):e2212533119. Goh JPZ, Ruchti F, Poh SE, Koh WLC, Tan KY, Lim YT, Thng STG, Sobota RM, Hoon SS, Liu C, O'Donoghue AJ, LeibundGut-Landmann S, Oon HH, Li H, Dawson TL. PMID: 36442106.
      View in: PubMed   Mentions:
    3. Peptide Amphiphile Mediated Co-assembly for Nanoplasmonic Sensing. Angew Chem Int Ed Engl. 2022 Nov 21; e202214394. Jin Z, Li Y, Li K, Zhou J, Yeung J, Ling C, Yim W, He T, Cheng Y, Xu M, Creyer MN, Chang YC, Fajtová P, Retout M, Qi B, Li S, O'Donoghue AJ, Jokerst JV. PMID: 36409652.
      View in: PubMed   Mentions:
    4. Spacer Matters: All-Peptide-Based Ligand for Promoting Interfacial Proteolysis and Plasmonic Coupling. Nano Lett. 2022 Nov 23; 22(22):8932-8940. Jin Z, Ling C, Li Y, Zhou J, Li K, Yim W, Yeung J, Chang YC, He T, Cheng Y, Fajtová P, Retout M, O'Donoghue AJ, Jokerst JV. PMID: 36346642.
      View in: PubMed   Mentions:
    5. Allergen Content and Protease Activity in Milk Feeds from Mothers of Preterm Infants. Breastfeed Med. 2022 Nov; 17(11):947-957. Luskin K, Mortazavi D, Bai-Tong S, Bertrand K, Chambers C, Schulkers-Escalante K, Ahmad A, Luedtke S, O'Donoghue AJ, Ghassemian M, Geng B, Leibel SL, Leibel SA. PMID: 36251466.
      View in: PubMed   Mentions:
    6. Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range. Biochemistry. 2022 09 06; 61(17):1904-1914. Yoon MC, Hook V, O'Donoghue AJ. PMID: 35981509; PMCID: PMC9454093.
      View in: PubMed   Mentions:
    7. A Self-Immolative Fluorescent Probe for Selective Detection of SARS-CoV-2 Main Protease. Anal Chem. 2022 08 30; 94(34):11728-11733. Xu M, Zhou J, Cheng Y, Jin Z, Clark AE, He T, Yim W, Li Y, Chang YC, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Todd MD, Jokerst JV. PMID: 35973073; PMCID: PMC9396966.
      View in: PubMed   Mentions:
    8. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2. J Chem Inf Model. 2022 Dec 26; 62(24):6553-6573. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35960688; PMCID: PMC9397563.
      View in: PubMed   Mentions:
    9. Native metabolomics identifies the rivulariapeptolide family of protease inhibitors. Nat Commun. 2022 08 08; 13(1):4619. Reher R, Aron AT, Fajtová P, Stincone P, Wagner B, Pérez-Lorente AI, Liu C, Shalom IYB, Bittremieux W, Wang M, Jeong K, Matos-Hernandez ML, Alexander KL, Caro-Diaz EJ, Naman CB, Scanlan JHW, Hochban PMM, Diederich WE, Molina-Santiago C, Romero D, Selim KA, Sass P, Brötz-Oesterhelt H, Hughes CC, Dorrestein PC, O'Donoghue AJ, Gerwick WH, Petras D. PMID: 35941113; PMCID: PMC9358669.
      View in: PubMed   Mentions:
    10. Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells. ACS Nano. 2022 Aug 23; 16(8):12305-12317. Cheng Y, Clark AE, Zhou J, He T, Li Y, Borum RM, Creyer MN, Xu M, Jin Z, Zhou J, Yim W, Wu Z, Fajtová P, O'Donoghue AJ, Carlin AF, Jokerst JV. PMID: 35878004; PMCID: PMC9344892.
      View in: PubMed   Mentions:    Fields:    
    11. Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions. ACS Omega. 2022 Jul 26; 7(29):25346-25352. Phan VV, Mosier C, Yoon MC, Glukhov E, Caffrey CR, O'Donoghue AJ, Gerwick WH, Hook V. PMID: 35910167; PMCID: PMC9330179.
      View in: PubMed   Mentions:
    12. Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS Chem Neurosci. 2022 07 06; 13(13):1992-2005. Podvin S, Jiang Z, Boyarko B, Rossitto LA, O'Donoghue A, Rissman RA, Hook V. PMID: 35758417; PMCID: PMC9264367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. J Med Chem. 2022 07 14; 65(13):9376-9395. Pillaiyar T, Flury P, Krüger N, Su H, Schäkel L, Barbosa Da Silva E, Eppler O, Kronenberger T, Nie T, Luedtke S, Rocha C, Sylvester K, Petry MRI, McKerrow JH, Poso A, Pöhlmann S, Gütschow M, O'Donoghue AJ, Xu Y, Müller CE, Laufer SA. PMID: 35709506; PMCID: PMC9216242.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L. Pharmaceuticals (Basel). 2022 Jun 13; 15(6). Meewan I, Kattoula J, Kattoula JY, Skinner D, Fajtová P, Giardini MA, Woodworth B, McKerrow JH, Lage de Siqueira-Neto J, O'Donoghue AJ, Abagyan R. PMID: 35745663; PMCID: PMC9230533.
      View in: PubMed   Mentions:
    15. Antiviral cyclic peptides targeting the main protease of SARS-CoV-2. Chem Sci. 2022 Mar 30; 13(13):3826-3836. Johansen-Leete J, Ullrich S, Fry SE, Frkic R, Bedding MJ, Aggarwal A, Ashhurst AS, Ekanayake KB, Mahawaththa MC, Sasi VM, Luedtke S, Ford DJ, O'Donoghue AJ, Passioura T, Larance M, Otting G, Turville S, Jackson CJ, Nitsche C, Payne RJ. PMID: 35432913; PMCID: PMC8966731.
      View in: PubMed   Mentions: 2  
    16. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi. J Med Chem. 2022 03 10; 65(5):4255-4269. Barbosa Da Silva E, Sharma V, Hernandez-Alvarez L, Tang AH, Stoye A, O'Donoghue AJ, Gerwick WH, Payne RJ, McKerrow JH, Podust LM. PMID: 35188371.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. Biochemistry. 2022 02 15; 61(4):228-238. Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O'Donoghue AJ, Hook V. PMID: 35119840; PMCID: PMC9096814.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    18. Peptidic Sulfhydryl for Interfacing Nanocrystals and Subsequent Sensing of SARS-CoV-2 Protease. Chemistry of Materials. 2022; 34(3):1259-1268. Jin, Zhicheng Yeung, Justin Zhou, Jiajing Cheng, Yong Li, Yi Mantri, Yash He, Tengyu Yim, Wonjun Xu, Ming Wu, Zhuohong Fajtova, Pavla Creyer, Matthew N. Moore, Colman Fu, Lei Penny, William F. O’Donoghue, Anthony J. Jokerst, Jesse V. View Publication.
    19. A Dual-Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain-like Proteases of SARS-CoV-2-Infected Cells for Accurate Detection and Rapid Inhibitor Screening. Angew Chem Int Ed Engl. 2022 02 21; 61(9):e202113617. Cheng Y, Borum RM, Clark AE, Jin Z, Moore C, Fajtová P, O'Donoghue AJ, Carlin AF, Jokerst JV. PMID: 34889013; PMCID: PMC8854376.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. A Charge-Switchable Zwitterionic Peptide for Rapid Detection of SARS-CoV-2 Main Protease. Angew Chem Int Ed Engl. 2022 02 21; 61(9):e202112995. Jin Z, Mantri Y, Retout M, Cheng Y, Zhou J, Jorns A, Fajtova P, Yim W, Moore C, Xu M, Creyer MN, Borum RM, Zhou J, Wu Z, He T, Penny WF, O'Donoghue AJ, Jokerst JV. PMID: 34936725; PMCID: PMC8854333.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases. ACS Chem Neurosci. 2022 01 19; 13(2):245-256. Yoon MC, Ames J, Mosier C, Jiang Z, Podvin S, O'Donoghue AJ, Hook V. PMID: 34986304; PMCID: PMC9070308.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. Improved Scalable Synthesis of Clinical Candidate KZR-616, a Selective Immunoproteasome Inhibitor. ChemistrySelect. 2021; 6(44):12461-12465. Almaliti, Jehad Fajtová, Pavla O'Donoghue, Anthony J. AlHindy, Momen Gerwick, William H. View Publication.
    23. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2022 02 24; 65(4):2956-2970. Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 34730959; PMCID: PMC8577376.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells. Proc Natl Acad Sci U S A. 2021 10 26; 118(43). Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenço AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz NP, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings CL, Rothenberg ME, Pöhlmann S, Whelan SPJ, O'Donoghue AJ, Craik CS, Janetka JW. PMID: 34635581; PMCID: PMC8694051.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 2021 09 17; 16(9):1628-1643. Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. PMID: 34416110; PMCID: PMC9104225.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. ACS Chem Neurosci. 2021 07 07; 12(13):2385-2398. Jiang Z, Lietz CB, Podvin S, Yoon MC, Toneff T, Hook V, O'Donoghue AJ. PMID: 34153188; PMCID: PMC8267839.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. Activatable Carbocyanine Dimers for Photoacoustic and Fluorescent Detection of Protease Activity. ACS Sens. 2021 06 25; 6(6):2356-2365. Moore C, Borum RM, Mantri Y, Xu M, Fajtová P, O'Donoghue AJ, Jokerst JV. PMID: 34038103; PMCID: PMC8375416.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454; PMCID: PMC8158845.
      View in: PubMed   Mentions: 3  
    29. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 2021 04 16; 16(4):642-650. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33787221; PMCID: PMC8029441.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    30. Insights into the catalytic properties of the mitochondrial rhomboid protease PARL. J Biol Chem. 2021 Jan-Jun; 296:100383. Lysyk L, Brassard R, Arutyunova E, Siebert V, Jiang Z, Takyi E, Morrison M, Young HS, Lemberg MK, O'Donoghue AJ, Lemieux MJ. PMID: 33556373; PMCID: PMC7966987.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    31. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv. 2020 Dec 24. Ashhurst AS, Tang AH, Fajtová P, Yoon M, Aggarwal A, Stoye A, Larance M, Beretta L, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CK, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 33398273; PMCID: PMC7781308.
      View in: PubMed   Mentions: 1  
    32. A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding. Science. 2020 09 25; 369(6511):1644-1649. Wendt G, Zhao L, Chen R, Liu C, O'Donoghue AJ, Caffrey CR, Reese ML, Collins JJ. PMID: 32973030; PMCID: PMC7875187.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. EBioMedicine. 2020 Oct; 60:102984. Sun J, LaRock DL, Skowronski EA, Kimmey JM, Olson J, Jiang Z, O'Donoghue AJ, Nizet V, LaRock CN. PMID: 32979835; PMCID: PMC7511813.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. Molecules. 2020 Sep 06; 25(18). Maffioli E, Jiang Z, Nonnis S, Negri A, Romeo V, Lietz CB, Hook V, Ristagno G, Baselli G, Kistler EB, Aletti F, O'Donoghue AJ, Tedeschi G. PMID: 32899982; PMCID: PMC7571063.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Engineering of multiple trypsin/chymotrypsin sites in Cry3A to enhance its activity against Monochamus alternatus Hope larvae. Pest Manag Sci. 2020 Sep; 76(9):3117-3126. Guo Y, Wang Y, O'Donoghue AJ, Jiang Z, Carballar-Lejarazú R, Liang G, Hu X, Wang R, Xu L, Guan X, Zhang F, Wu S. PMID: 32323409.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. Giant magnetoresistive biosensors for real-time quantitative detection of protease activity. Sci Rep. 2020 05 14; 10(1):7941. Adem S, Jain S, Sveiven M, Zhou X, O'Donoghue AJ, Hall DA. PMID: 32409675; PMCID: PMC7224196.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    37. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    38. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. PMID: 32295833; PMCID: PMC7261814.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    39. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Front Cell Infect Microbiol. 2020; 10:66. Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. PMID: 32175287; PMCID: PMC7054455.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    40. Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties. ACS Chem Biol. 2020 03 20; 15(3):751-757. Keller L, Canuto KM, Liu C, Suzuki BM, Almaliti J, Sikandar A, Naman CB, Glukhov E, Luo D, Duggan BM, Luesch H, Koehnke J, O'Donoghue AJ, Gerwick WH. PMID: 31935054; PMCID: PMC7480958.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts. Biol Chem. 2019 11 26; 400(12):1629-1638. Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 31256057.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503; PMCID: PMC6811414.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant. ACS Omega. 2019 Oct 15; 4(16):16999-17008. Meewan I, Zhang X, Roy S, Ballatore C, O'Donoghue AJ, Schooley RT, Abagyan R. PMID: 31646247; PMCID: PMC6796237.
      View in: PubMed   Mentions: 4  
    44. The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni. ACS Infect Dis. 2019 10 11; 5(10):1802-1812. Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. PMID: 31355632; PMCID: PMC7283364.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    45. Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain). Parasit Vectors. 2019 Jul 30; 12(1):383. Chaimon S, Limpanont Y, Reamtong O, Ampawong S, Phuphisut O, Chusongsang P, Ruangsittichai J, Boonyuen U, Watthanakulpanich D, O'Donoghue AJ, Caffrey CR, Adisakwattana P. PMID: 31362766; PMCID: PMC6668146.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsPHPublic Health
    46. Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome. Microbiome. 2019 02 13; 7(1):23. Quinn RA, Adem S, Mills RH, Comstock W, DeRight Goldasich L, Humphrey G, Aksenov AA, Melnik AV, da Silva R, Ackermann G, Bandeira N, Gonzalez DJ, Conrad D, O'Donoghue AJ, Knight R, Dorrestein PC. PMID: 30760325; PMCID: PMC6375204.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    47. Quantitative Multiplex Substrate Profiling of Peptidases by Mass Spectrometry. Mol Cell Proteomics. 2019 05; 18(5):968-981. Lapek JD, Jiang Z, Wozniak JM, Arutyunova E, Wang SC, Lemieux MJ, Gonzalez DJ, O'Donoghue AJ. PMID: 30705125; PMCID: PMC6495252.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    48. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. J Med Chem. 2019 01 24; 62(2):480-490. Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW. PMID: 30571119.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    49. An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases. Biol Chem. 2018 11 27; 399(12):1389-1397. Arutyunova E, Jiang Z, Yang J, Kulepa AN, Young HS, Verhelst S, O'Donoghue AJ, Lemieux MJ. PMID: 30044760.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    50. Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome. Biol Chem. 2018 11 27; 399(12):1375-1388. Beekman C, Jiang Z, Suzuki BM, Palmer JM, Lindner DL, O'Donoghue AJ, Knudsen GM, Bennett RJ. PMID: 30367778.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    51. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. PLoS Negl Trop Dis. 2018 10; 12(10):e0006923. Rebello KM, McKerrow JH, Mota EM, O'Donoghue AJ, Neves-Ferreira AGC. PMID: 30379807; PMCID: PMC6231675.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro. ACS Chem Biol. 2018 09 21; 13(9):2513-2521. Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW. PMID: 30085657; PMCID: PMC7293822.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    53. Validation of Babesia proteasome as a drug target. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):394-402. Jalovecka M, Hartmann D, Miyamoto Y, Eckmann L, Hajdusek O, O'Donoghue AJ, Sojka D. PMID: 30103207; PMCID: PMC6092455.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    54. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. PLoS Negl Trop Dis. 2018 04; 12(4):e0006446. Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M. PMID: 29677188; PMCID: PMC5931690.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    55. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596; PMCID: PMC5917446.
      View in: PubMed   Mentions: 4  
    56. Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 05; 29(5):935-947. Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. PMID: 29556927; PMCID: PMC5943185.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    57. Skin Commensal Malassezia globosa Secreted Protease Attenuates Staphylococcus aureus Biofilm Formation. J Invest Dermatol. 2018 05; 138(5):1137-1145. Li H, Goh BN, Teh WK, Jiang Z, Goh JPZ, Goh A, Wu G, Hoon SS, Raida M, Camattari A, Yang L, O'Donoghue AJ, Dawson TL. PMID: 29246799.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    58. Global substrate specificity profiling of post-translational modifying enzymes. Protein Sci. 2018 03; 27(3):584-594. Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS. PMID: 29168252; PMCID: PMC5818756.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    59. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. Elife. 2017 11 28; 6. Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS. PMID: 29182146; PMCID: PMC5705213.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    60. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 08 10; 60(15):6721-6732. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. PMID: 28696697; PMCID: PMC5554889.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    61. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria. ACS Chem Biol. 2017 06 16; 12(6):1556-1565. Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. PMID: 28414448; PMCID: PMC5575927.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    62. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts. Clin Cancer Res. 2017 Aug 15; 23(16):4865-4874. Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS. PMID: 28424202; PMCID: PMC5712228.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    63. Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs. Anal Chem. 2017 04 18; 89(8):4550-4558. Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS. PMID: 28322550; PMCID: PMC5500290.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    64. Targeting proteasomes in infectious organisms to combat disease. FEBS J. 2017 05; 284(10):1503-1517. Bibo-Verdugo B, Jiang Z, Caffrey CR, O'Donoghue AJ. PMID: 28122162.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    65. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. PLoS Pathog. 2016 Dec; 12(12):e1006051. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. PMID: 27977806; PMCID: PMC5158083.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    66. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors. Biol Chem. 2016 09 01; 397(9):871-81. O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS. PMID: 27149201; PMCID: PMC5712230.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    67. IL-1β is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016 Aug; 1(2). LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. PMID: 28331908; PMCID: PMC5358671.
      View in: PubMed   Mentions: 41     Fields:    
    68. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047; PMCID: PMC4976874.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    69. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. ACS Infect Dis. 2016 11 11; 2(11):807-815. Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. PMID: 27739665; PMCID: PMC5109297.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    70. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500; PMCID: PMC4833263.
      View in: PubMed   Mentions: 46     Fields:    
    71. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 2016 Feb 11; 530(7589):233-6. Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. PMID: 26863983; PMCID: PMC4755332.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    72. Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion. Mar Biotechnol (NY). 2016 Apr; 18(2):201-14. Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F. PMID: 26613762.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    73. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. 2016 Mar; 122:99-109. Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. PMID: 26409899; PMCID: PMC4747843.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    74. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7478-83. O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. PMID: 25944934; PMCID: PMC4475985.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    75. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor. Biochem J. 2015 Jan 01; 465(1):163-73. Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. PMID: 25279554.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    76. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. PLoS One. 2013; 8(9):e75141. O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. PMID: 24073241; PMCID: PMC3779220.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    77. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PMID: 23875031; PMCID: PMC3708847.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    78. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. J Biol Chem. 2013 May 03; 288(18):12489-99. Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. PMID: 23504313; PMCID: PMC3642297.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    79. Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov; 9(11):1095-100. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. PMID: 23023596; PMCID: PMC3707110.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    80. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. PMID: 22539347; PMCID: PMC3375538.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    81. Global landscape of HIV-human protein complexes. Nature. 2011 Dec 21; 481(7381):365-70. Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. PMID: 22190034; PMCID: PMC3310911.
      View in: PubMed   Mentions: 364     Fields:    Translation:HumansCells
    82. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology (Reading). 2009 Nov; 155(Pt 11):3673-3682. Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. PMID: 19556294; PMCID: PMC2888130.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    83. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. PMID: 18701454; PMCID: PMC2570886.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    84. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. J Biol Chem. 2008 Oct 24; 283(43):29186-95. O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. PMID: 18687686; PMCID: PMC2570871.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    85. Cloning and characterization of osteoclast precursors from the RAW264.7 cell line. In Vitro Cell Dev Biol Anim. 2006 Jul-Aug; 42(7):182-8. Cuetara BL, Crotti TN, O'Donoghue AJ, McHugh KP. PMID: 16948499; PMCID: PMC2883882.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
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