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Gabriel Haddad

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0735
La Jolla CA 92093
Phone858-822-4740
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms Regulating Tolerance to Oxidative Stress in the Brain
    NIH/NINDS R21NS101652Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Study of iPS cells-derived neural and glial cells from subjects with Monge's disease
    NIH/NINDS R21NS097899Feb 1, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Endothelin receptors modulate cardiorespiratory function during hypoxia
    NIH/NHLBI R01HL127403Jun 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Molecular mechanisms of hypoxia tolerance and susceptibility
    NIH/NHLBI P01HL098053Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Resistance to oxidant injury
    NIH/NHLBI R21HL093611Apr 1, 2009 - Mar 31, 2011
    Role: Principal Investigator
    Hypoxia and Consequences: From Molecule to Malady
    NIH/NHLBI R13HL093851Jun 15, 2008 - Jun 14, 2009
    Role: Principal Investigator
    Sleep Mechanisms in Children: Role of Metabolism
    NIH/NHLBI R01HL070919Sep 23, 2002 - Jan 31, 2004
    Role: Principal Investigator
    Roles and mechanisms of Slo and Slack Channels in Brain
    NIH P01NS042202Sep 4, 2001 - Aug 31, 2006
    Role: Co-Investigator
    CYCLICAL HYPOXIA--SUSCEPTIBILITY TO NEURONAL INJURY
    NIH/NHLBI R01HL066327Sep 30, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Molecular basis of cell tolerance to 02 deprivation
    NIH/NINDS R01NS037756Jan 1, 2000 - Apr 3, 2011
    Role: Principal Investigator
    IONIC &METABOLIC MECHANISMS IN HYPOXIC NEURONAL INJURY
    NIH/NINDS R01NS035918Jan 1, 1997 - Dec 31, 2000
    Role: Principal Investigator
    Hypoxia in Development;Injury and Adaptation Mechanisms
    NIH/NICHD P01HD032573Feb 10, 1995 - Jul 31, 2011
    Role: Principal Investigator
    Training in Translational Lung Biology and Pathobiology
    NIH/NHLBI T32HL007778Jul 15, 1994 - Jun 30, 2020
    Role: Principal Investigator
    PRENATAL HYPOXIA--CELLULAR BRAINSTEM MATURATION
    NIH/NICHD R01HD028940Sep 30, 1991 - Aug 31, 1994
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    POSTNATAL MATURATION &MODULATION OF RESPIRATORY NEURONS
    NIH/NHLBI R01HL039924Sep 30, 1987 - Jun 30, 1998
    Role: Principal Investigator
    BRAIN INJURY DUE TO NEONATAL SEIZURE
    NIH/NINDS R01NS024605Jul 1, 1986 - Jun 30, 1993
    Role: Principal Investigator
    RESPIRATORY MUSCLE TRAINING, METABOLIC &STRUCTURAL BASE
    NIH/NHLBI R01HL034467Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator
    ENDORPHINS, SLEEP AND MATURATION OF HYPOXIC RESPONSE
    NIH/NICHD R01HD015736Jul 1, 1981 - Aug 31, 1995
    Role: Principal Investigator
    MUSCULAR FATIGUE
    NIH/NINDS R01NS014756Jul 1, 1978 - Dec 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yao H, Zhao H, Wang J, Haddad G. Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness. Neuroscience. 2018 Apr 01; 375:25-33. PMID: 29438800.
      View in: PubMed
    2. Wu W, Yao H, Zhao HW, Wang J, Haddad G. Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge's Disease. Neuroscience. 2018 Mar 15; 374:70-79. PMID: 29355592.
      View in: PubMed
    3. Zhao H, Perkins GA, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad G. MITOCHONDRIAL DYSFUNCTION IN IPSC-DERIVED NEURONS OF SUBJECTS WITH CHRONIC MOUNTAIN SICKNESS. J Appl Physiol (1985). 2017 Dec 21. PMID: 29357502.
      View in: PubMed
    4. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad G. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168. PMID: 29029226.
      View in: PubMed
    5. Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad G. Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. PMID: 28678519.
      View in: PubMed
    6. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad G. High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282. PMID: 28951950.
      View in: PubMed
    7. Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad G, McCulloch AD. Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo. J Physiol. 2017 Sep 01; 595(17):5797-5813. PMID: 28688178.
      View in: PubMed
    8. Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad G. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 Nov 14; 213(12):2729-2744. PMID: 27821551.
      View in: PubMed
    9. Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad G. The Na+/HCO3- co-transporter is protective during ischemia in astrocytes. Neuroscience. 2016 Dec 17; 339:329-337. PMID: 27717805.
      View in: PubMed
    10. Imamura T, Poulsen O, Haddad G. Intermittent hypoxia induces murine macrophage foam cell formation by IKK-ß-dependent NF-?B pathway activation. J Appl Physiol (1985). 2016 Sep 01; 121(3):670-7. PMID: 27471237.
      View in: PubMed
    11. Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad G, Korol AB. Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits. BMC Biol. 2015 Nov 27; 13:101. PMID: 26614097; PMCID: PMC4661966.
    12. Jha AR, Zhou D, Brown CD, Kreitman M, Haddad G, White KP. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. PMID: 26576852; PMCID: PMC4866538.
    13. Zarndt R, Piloto S, Powell FL, Haddad G, Bodmer R, Ocorr K. Cardiac responses to hypoxia and reoxygenation in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 01; 309(11):R1347-57. PMID: 26377557; PMCID: PMC4698404 [Available on 12/01/16].
    14. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad G, Powell FL, Makino A, Mehta D, Yuan JX. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. PMID: 25569851; PMCID: PMC4566064.
    15. Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad G. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. PMID: 26240367; PMCID: PMC4547246.
    16. Manchenkov T, Pasillas MP, Haddad G, Imam FB. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 03; 5(6):1107-16. PMID: 25840431; PMCID: PMC4478541.
    17. Pamenter ME, Haddad G. High-throughput cell death assays. Methods Mol Biol. 2015; 1254:153-63. PMID: 25431064.
      View in: PubMed
    18. Huang H, Lu-Bo Y, Haddad G. A Drosophila ABC transporter regulates lifespan. PLoS Genet. 2014 Dec; 10(12):e1004844. PMID: 25474322; PMCID: PMC4256198.
    19. Ronen R, Zhou D, Bafna V, Haddad G. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403-12. PMID: 25362634; PMCID: PMC4280153.
    20. Gersten M, Zhou D, Azad P, Haddad G, Subramaniam S. Wnt pathway activation increases hypoxia tolerance during development. PLoS One. 2014; 9(8):e103292. PMID: 25093834; PMCID: PMC4122365.
    21. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. PMID: 24809345; PMCID: PMC4014425.
    22. Gan Z, Wang J, Salomonis N, Stowe JC, Haddad G, McCulloch AD, Altintas I, Zambon AC. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. BMC Bioinformatics. 2014 Mar 12; 15:69. PMID: 24621103; PMCID: PMC3975178.
    23. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad G. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36. PMID: 24555826; PMCID: PMC4054780.
    24. Gu XQ, Pamenter ME, Siemen D, Sun X, Haddad G. Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma. Glia. 2014 Apr; 62(4):504-13. PMID: 24446243.
      View in: PubMed
    25. Pamenter ME, Haddad G. Do BK channels mediate glioma hypoxia-tolerance? Channels (Austin). 2014; 8(3):176-7. PMID: 24813649.
      View in: PubMed
    26. Felfly H, Haddad G. Hematopoietic stem cells: potential new applications for translational medicine. J Stem Cells. 2014; 9(3):163-97. PMID: 25157450.
      View in: PubMed
    27. Hartley I, Elkhoury FF, Heon Shin J, Xie B, Gu X, Gao Y, Zhou D, Haddad G. Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures. PLoS One. 2013; 8(10):e77859. PMID: 24205000; PMCID: PMC3808424.
    28. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad G. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54. PMID: 24567903; PMCID: PMC3929909.
    29. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad G, Zhou D, Liu S. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. PMID: 24069262; PMCID: PMC3771901.
    30. Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad G, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704. PMID: 23990245; PMCID: PMC3882740.
    31. Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad G. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62. PMID: 23954164; PMCID: PMC3769925.
    32. Zhou D, Haddad G. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet. 2013; 14:25-43. PMID: 23808366.
      View in: PubMed
    33. Xie L, Ng C, Ali T, Valencia R, Ferreira BL, Xue V, Tanweer M, Zhou D, Haddad G, Bourne PE, Xie L. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013; 14 Suppl 3:S9. PMID: 23819581; PMCID: PMC3665574.
    34. Pamenter ME, Perkins GA, Gu XQ, Ellisman MH, Haddad G. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 2013; 8(4):e60804. PMID: 23577164; PMCID: PMC3618322.
    35. Sieck GC, Haddad G, Lucchesi P. Physiology's impact: discovering life. Physiology (Bethesda). 2013 Mar; 28(2):62-3. PMID: 23455765; PMCID: PMC3768088.
    36. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL, Haddad G, Yao H. Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. PMID: 23847708.
      View in: PubMed
    37. Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH, Haddad G. Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 2012; 7(12):e51469. PMID: 23251543; PMCID: PMC3520810.
    38. Azad P, Haddad G. Genetic animal models of preconditioning. Transl Stroke Res. 2013 Feb; 4(1):51-5. PMID: 23565128; PMCID: PMC3614364.
    39. Azad P, Zhou D, Zarndt R, Haddad G. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda). 2012 Oct; 2(10):1169-78. PMID: 23050227; PMCID: PMC3464109.
    40. Ryu J, Haddad G, Carlo WA. Clinical effectiveness and safety of permissive hypercapnia. Clin Perinatol. 2012 Sep; 39(3):603-12. PMID: 22954272.
      View in: PubMed
    41. Kinney HC, Rognum TO, Nattie EE, Haddad G, Hyma B, McEntire B, Paterson DS, Crandall L, Byard RW. Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous. Forensic Sci Med Pathol. 2012 Dec; 8(4):414-25. PMID: 22941540.
      View in: PubMed
    42. Pamenter ME, Ryu J, Hua ST, Perkins GA, Mendiola VL, Gu XQ, Ellisman MH, Haddad G. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 2012; 7(8):e43995. PMID: 22937143; PMCID: PMC3427179.
    43. Heinrichsen ET, Haddad G. Role of high-fat diet in stress response of Drosophila. PLoS One. 2012; 7(8):e42587. PMID: 22870336; PMCID: PMC3411628.
    44. Pamenter ME, Hogg DW, Gu XQ, Buck LT, Haddad G. Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. J Cereb Blood Flow Metab. 2012 Nov; 32(11):2033-43. PMID: 22805876; PMCID: PMC3493991.
    45. Lesser DJ, Haddad G, Bush RA, Pian MS. The utility of a portable recording device for screening of obstructive sleep apnea in obese adolescents. J Clin Sleep Med. 2012 Jun 15; 8(3):271-7. PMID: 22701384; PMCID: PMC3365085.
    46. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad G, Zhou D. Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One. 2012; 7(5):e36801. PMID: 22574227; PMCID: PMC3344937.
    47. Pamenter ME, Ali SS, Tang Q, Finley JC, Gu XQ, Dugan LL, Haddad G. An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons. Brain Res. 2012 May 03; 1452:165-72. PMID: 22459046; PMCID: PMC3326196.
    48. Zhao HW, Ali SS, Haddad G. Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production? Antioxid Redox Signal. 2012 May 15; 16(10):1071-6. PMID: 22229946; PMCID: PMC3315163.
    49. Mittal M, Gu XQ, Pak O, Pamenter ME, Haag D, Fuchs DB, Schermuly RT, Ghofrani HA, Brandes RP, Seeger W, Grimminger F, Haddad G, Weissmann N. Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med. 2012 Mar 15; 52(6):1033-42. PMID: 22222468.
      View in: PubMed
    50. Udpa N, Zhou D, Haddad G, Bafna V. Tests of selection in pooled case-control data: an empirical study. Front Genet. 2011; 2:83. PMID: 22303377; PMCID: PMC3268381.
    51. Haddad G. Does the brain gain back energy during sleep? But what does it mean? Sleep. 2011 Jul 01; 34(7):835-6. PMID: 21731130; PMCID: PMC3119555.
    52. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad G. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. PMID: 21677276; PMCID: PMC3174756.
    53. Azad P, Ryu J, Haddad G. Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic Biol Med. 2011 Jul 15; 51(2):530-8. PMID: 21616137; PMCID: PMC3138732.
    54. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad G. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. PMID: 21262834; PMCID: PMC3038716.
    55. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad G. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
      View in: PubMed
    56. Harrison JF, Haddad G. Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster. Annu Rev Physiol. 2011; 73:95-113. PMID: 20936942.
      View in: PubMed
    57. Zhao HW, Zhou D, Haddad G. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem. 2011 Feb 25; 286(8):6211-8. PMID: 21148307; PMCID: PMC3057857.
    58. Zhao HW, Zhou D, Nizet V, Haddad G. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. PMID: 20668515; PMCID: PMC2909141.
    59. Felfly H, Muotri A, Yao H, Haddad G. Hematopoietic stem cell transplantation protects mice from lethal stroke. Exp Neurol. 2010 Oct; 225(2):284-93. PMID: 20547154; PMCID: PMC2963425.
    60. Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad G. Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy. Physiol Genomics. 2010 Aug; 42(3):374-83. PMID: 20460605; PMCID: PMC2929882.
    61. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad G, Poellinger L, Peet DJ, Powell F, Johnson RS. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. PMID: 20399150; PMCID: PMC2893150.
    62. Ryu J, Heldt GP, Nguyen M, Gavrialov O, Haddad G. Chronic hypercapnia alters lung matrix composition in mouse pups. J Appl Physiol (1985). 2010 Jul; 109(1):203-10. PMID: 20360436; PMCID: PMC2904197.
    63. Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad G, Ali SS. Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1594-602. PMID: 20357179; PMCID: PMC2889641.
    64. Iacobas DA, Iacobas S, Haddad G. Heart rhythm genomic fabric in hypoxia. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1769-74. PMID: 20044980; PMCID: PMC2849310.
    65. Sun X, Yao H, Douglas RM, Gu XQ, Wang J, Haddad G. Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures. J Neurochem. 2010 Jan; 112(2):377-88. PMID: 19860861; PMCID: PMC4524356.
    66. Demory ML, Boerner JL, Davidson R, Faust W, Miyake T, Lee I, Hüttemann M, Douglas R, Haddad G, Parsons SJ. Epidermal growth factor receptor translocation to the mitochondria: regulation and effect. J Biol Chem. 2009 Dec 25; 284(52):36592-604. PMID: 19840943; PMCID: PMC2794774.
    67. Azad P, Haddad G. Survival in acute and severe low o environment: use of a genetic model system. Ann N Y Acad Sci. 2009 Oct; 1177:39-47. PMID: 19845605.
      View in: PubMed
    68. Feala JD, Coquin L, Zhou D, Haddad G, Paternostro G, McCulloch AD. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 09; 3:91. PMID: 19740440; PMCID: PMC2749811.
    69. Zhou D, Visk DW, Haddad G. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 2009 Sep; 66(3):239-47. PMID: 19542900.
      View in: PubMed
    70. Guma M, Rius J, Duong-Polk KX, Haddad G, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. PMID: 19433784; PMCID: PMC2688966.
    71. Azad P, Zhou D, Russo E, Haddad G. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. PLoS One. 2009; 4(4):e5371. PMID: 19401761; PMCID: PMC2670512.
    72. Yao H, Felfly H, Wang J, Zhou D, Haddad G. DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms. J Neurochem. 2009 Feb; 108(3):835-46. PMID: 19077053; PMCID: PMC2782475.
    73. Douglas RM, Haddad G. Can O2 dysregulation induce premature aging? Physiology (Bethesda). 2008 Dec; 23:333-49. PMID: 19074741.
      View in: PubMed
    74. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad G. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 2008 Oct; 4(10):e1000221. PMID: 18927626; PMCID: PMC2556400.
    75. Chen LM, Haddad G, Boron WF. Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Brain Res. 2008 Oct 31; 1238:85-92. PMID: 18775686; PMCID: PMC3222586.
    76. Cheng Y, Gu XQ, Bednarczyk P, Wiedemann FR, Haddad G, Siemen D. Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore. Cell Physiol Biochem. 2008; 22(1-4):127-36. PMID: 18769039.
      View in: PubMed
    77. Iacobas DA, Fan C, Iacobas S, Haddad G. Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival. Funct Integr Genomics. 2008 Aug; 8(3):265-75. PMID: 18446526; PMCID: PMC2856931.
    78. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad G, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192; PMCID: PMC2669289.
    79. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. PMID: 18423195; PMCID: PMC2849644.
    80. Farahani R, Kanaan A, Gavrialov O, Brunnert S, Douglas RM, Morcillo P, Haddad G. Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development. Pediatr Pulmonol. 2008 Jan; 43(1):20-8. PMID: 18041750.
      View in: PubMed
    81. Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad G, Tibboel D, Seeger W, Eickelberg O, Morty RE. TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn. 2008 Jan; 237(1):259-69. PMID: 18095342.
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    82. Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad G. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics. 2008 Feb 19; 32(3):370-9. PMID: 18056785.
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