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Gabriel Haddad

Title(s)Adjunct Professor, Neurosciences
SchoolHealth Sciences
Phone858-822-4740
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    Collapse Research 
    Collapse Research Activities and Funding
    Molecular Basis of Hypoxia-Induced Excessive Erythrocytosis
    NIH/NHLBI R01HL146530Jul 5, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Mechanisms Regulating Tolerance to Oxidative Stress in the Brain
    NIH/NINDS R21NS101652Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Study of iPS cells-derived neural and glial cells from subjects with Monge's disease
    NIH/NINDS R21NS097899Feb 1, 2017 - Jan 31, 2019
    Role: Principal Investigator
    Endothelin receptors modulate cardiorespiratory function during hypoxia
    NIH/NHLBI R01HL127403Jun 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Molecular mechanisms of hypoxia tolerance and susceptibility
    NIH/NHLBI P01HL098053Jul 1, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Resistance to oxidant injury
    NIH/NHLBI R21HL093611Apr 1, 2009 - Mar 31, 2011
    Role: Principal Investigator
    Hypoxia and Consequences: From Molecule to Malady
    NIH/NHLBI R13HL093851Jun 15, 2008 - Jun 14, 2009
    Role: Principal Investigator
    Sleep Mechanisms in Children: Role of Metabolism
    NIH/NHLBI R01HL070919Sep 23, 2002 - Jan 31, 2004
    Role: Principal Investigator
    Roles and mechanisms of Slo and Slack Channels in Brain
    NIH P01NS042202Sep 4, 2001 - Aug 31, 2006
    Role: Co-Investigator
    CYCLICAL HYPOXIA--SUSCEPTIBILITY TO NEURONAL INJURY
    NIH/NHLBI R01HL066327Sep 30, 2000 - Aug 31, 2005
    Role: Principal Investigator
    Molecular basis of cell tolerance to 02 deprivation
    NIH/NINDS R01NS037756Jan 1, 2000 - Apr 3, 2011
    Role: Principal Investigator
    IONIC &METABOLIC MECHANISMS IN HYPOXIC NEURONAL INJURY
    NIH/NINDS R01NS035918Jan 1, 1997 - Dec 31, 2000
    Role: Principal Investigator
    Hypoxia in Development;Injury and Adaptation Mechanisms
    NIH/NICHD P01HD032573Feb 10, 1995 - Jul 31, 2011
    Role: Principal Investigator
    Training in Translational Lung Biology and Pathobiology
    NIH/NHLBI T32HL007778Jul 15, 1994 - Jun 30, 2020
    Role: Principal Investigator
    PRENATAL HYPOXIA--CELLULAR BRAINSTEM MATURATION
    NIH/NICHD R01HD028940Sep 30, 1991 - Aug 31, 1994
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    POSTNATAL MATURATION &MODULATION OF RESPIRATORY NEURONS
    NIH/NHLBI R01HL039924Sep 30, 1987 - Jun 30, 1998
    Role: Principal Investigator
    BRAIN INJURY DUE TO NEONATAL SEIZURE
    NIH/NINDS R01NS024605Jul 1, 1986 - Jun 30, 1993
    Role: Principal Investigator
    RESPIRATORY MUSCLE TRAINING, METABOLIC &STRUCTURAL BASE
    NIH/NHLBI R01HL034467Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator
    ENDORPHINS, SLEEP AND MATURATION OF HYPOXIC RESPONSE
    NIH/NICHD R01HD015736Jul 1, 1981 - Aug 31, 1995
    Role: Principal Investigator
    MUSCULAR FATIGUE
    NIH/NINDS R01NS014756Jul 1, 1978 - Dec 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tripathi A, Xu ZZ, Xue J, Poulsen O, Gonzalez A, Humphrey G, Meehan MJ, Melnik AV, Ackermann G, Zhou D, Malhotra A, Haddad GG, Dorrestein PC, Knight R. Intermittent Hypoxia and Hypercapnia Reproducibly Change the Gut Microbiome and Metabolome across Rodent Model Systems. mSystems. 2019 Mar-Apr; 4(2). PMID: 31058230.
      View in: PubMed
    2. Stobdan T, Haddad GG. Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders. J Lung Health Dis. 2019; 3(2):29-30. PMID: 31304480.
      View in: PubMed
    3. Stobdan T, Sahoo D, Azad P, Hartley I, Heinrichsen E, Zhou D, Haddad GG. High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. PLoS One. 2019; 14(3):e0213474. PMID: 30861021.
      View in: PubMed
    4. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 Nov 01; 103(5):826. PMID: 30388405.
      View in: PubMed
    5. Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG. Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders. Eur J Hum Genet. 2019 01; 27(1):150-159. PMID: 30254217.
      View in: PubMed
    6. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 Sep 06; 103(3):431-439. PMID: 30100084.
      View in: PubMed
    7. Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG. Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia. J Mol Med (Berl). 2018 Sep; 96(9):975-982. PMID: 30069745.
      View in: PubMed
    8. Xue J, Zhou D, Poulsen O, Hartley I, Imamura T, Xie EX, Haddad GG. Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice. Physiol Genomics. 2018 Oct 01; 50(10):846-861. PMID: 30029588.
      View in: PubMed
    9. Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG. Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems. 2018 May-Jun; 3(3). PMID: 29896566.
      View in: PubMed
    10. Yao H, Zhao H, Wang J, Haddad GG. Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness. Neuroscience. 2018 04 01; 375:25-33. PMID: 29438800.
      View in: PubMed
    11. Wu W, Yao H, Zhao HW, Wang J, Haddad GG. Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge's Disease. Neuroscience. 2018 03 15; 374:70-79. PMID: 29355592.
      View in: PubMed
    12. Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG. Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness. J Appl Physiol (1985). 2018 Sep 01; 125(3):832-840. PMID: 29357502.
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    13. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168. PMID: 29029226.
      View in: PubMed
    14. Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG. Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. PMID: 28678519.
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    15. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG. High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282. PMID: 28951950.
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    16. Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD. Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo. J Physiol. 2017 09 01; 595(17):5797-5813. PMID: 28688178.
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    17. Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 11 14; 213(12):2729-2744. PMID: 27821551.
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    18. Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG. The Na+/HCO3- co-transporter is protective during ischemia in astrocytes. Neuroscience. 2016 Dec 17; 339:329-337. PMID: 27717805.
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    19. Imamura T, Poulsen O, Haddad GG. Intermittent hypoxia induces murine macrophage foam cell formation by IKK-ß-dependent NF-?B pathway activation. J Appl Physiol (1985). 2016 09 01; 121(3):670-7. PMID: 27471237.
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    20. Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad GG, Korol AB. Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits. BMC Biol. 2015 Nov 27; 13:101. PMID: 26614097; PMCID: PMC4661966.
    21. Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. PMID: 26576852; PMCID: PMC4866538.
    22. Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K. Cardiac responses to hypoxia and reoxygenation in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 01; 309(11):R1347-57. PMID: 26377557.
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    23. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. PMID: 25569851; PMCID: PMC4566064.
    24. Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. PMID: 26240367; PMCID: PMC4547246.
    25. Manchenkov T, Pasillas MP, Haddad GG, Imam FB. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 03; 5(6):1107-16. PMID: 25840431; PMCID: PMC4478541.
    26. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG. Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Neuroscience. 2015 Mar 12; 288:187-99. PMID: 25559931; PMCID: PMC4323892.
    27. Pamenter ME, Haddad GG. High-throughput cell death assays. Methods Mol Biol. 2015; 1254:153-63. PMID: 25431064.
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    28. Huang H, Lu-Bo Y, Haddad GG. A Drosophila ABC transporter regulates lifespan. PLoS Genet. 2014 Dec; 10(12):e1004844. PMID: 25474322; PMCID: PMC4256198.
    29. Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri AR. Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry. 2015 Nov; 20(11):1350-65. PMID: 25385366; PMCID: PMC4427554.
    30. Ronen R, Zhou D, Bafna V, Haddad GG. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403-12. PMID: 25362634; PMCID: PMC4280153.
    31. Gersten M, Zhou D, Azad P, Haddad GG, Subramaniam S. Wnt pathway activation increases hypoxia tolerance during development. PLoS One. 2014; 9(8):e103292. PMID: 25093834; PMCID: PMC4122365.
    32. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. PMID: 24809345.
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    33. Gan Z, Wang J, Salomonis N, Stowe JC, Haddad GG, McCulloch AD, Altintas I, Zambon AC. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. BMC Bioinformatics. 2014 Mar 12; 15:69. PMID: 24621103; PMCID: PMC3975178.
    34. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36. PMID: 24555826; PMCID: PMC4054780.
    35. Gu XQ, Pamenter ME, Siemen D, Sun X, Haddad GG. Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma. Glia. 2014 Apr; 62(4):504-13. PMID: 24446243.
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    36. Pamenter ME, Haddad GG. Do BK channels mediate glioma hypoxia-tolerance? Channels (Austin). 2014; 8(3):176-7. PMID: 24813649.
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    37. Felfly H, Haddad GG. Hematopoietic stem cells: potential new applications for translational medicine. J Stem Cells. 2014; 9(3):163-97. PMID: 25157450.
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    38. Hartley I, Elkhoury FF, Heon Shin J, Xie B, Gu X, Gao Y, Zhou D, Haddad GG. Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures. PLoS One. 2013; 8(10):e77859. PMID: 24205000; PMCID: PMC3808424.
    39. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54. PMID: 24567903; PMCID: PMC3929909.
    40. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. PMID: 24069262; PMCID: PMC3771901.
    41. Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704. PMID: 23990245; PMCID: PMC3882740.
    42. Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62. PMID: 23954164.
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    43. Zhou D, Haddad GG. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet. 2013; 14:25-43. PMID: 23808366.
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    44. Xie L, Ng C, Ali T, Valencia R, Ferreira BL, Xue V, Tanweer M, Zhou D, Haddad GG, Bourne PE, Xie L. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013; 14 Suppl 3:S9. PMID: 23819581; PMCID: PMC3665574.
    45. Pamenter ME, Perkins GA, Gu XQ, Ellisman MH, Haddad GG. DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 2013; 8(4):e60804. PMID: 23577164; PMCID: PMC3618322.
    46. Sieck GC, Haddad GG, Lucchesi P. Physiology's impact: discovering life. Physiology (Bethesda). 2013 Mar; 28(2):62-3. PMID: 23455765; PMCID: PMC3768088.
    47. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL, Haddad GG, Yao H. Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. PMID: 23847708.
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    48. Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH, Haddad GG. Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 2012; 7(12):e51469. PMID: 23251543; PMCID: PMC3520810.
    49. Azad P, Haddad GG. Genetic animal models of preconditioning. Transl Stroke Res. 2013 Feb; 4(1):51-5. PMID: 23565128; PMCID: PMC3614364.
    50. Azad P, Zhou D, Zarndt R, Haddad GG. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda). 2012 Oct; 2(10):1169-78. PMID: 23050227; PMCID: PMC3464109.
    51. Ryu J, Haddad G, Carlo WA. Clinical effectiveness and safety of permissive hypercapnia. Clin Perinatol. 2012 Sep; 39(3):603-12. PMID: 22954272.
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    52. Kinney HC, Rognum TO, Nattie EE, Haddad GG, Hyma B, McEntire B, Paterson DS, Crandall L, Byard RW. Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous. Forensic Sci Med Pathol. 2012 Dec; 8(4):414-25. PMID: 22941540.
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    53. Pamenter ME, Ryu J, Hua ST, Perkins GA, Mendiola VL, Gu XQ, Ellisman MH, Haddad GG. DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 2012; 7(8):e43995. PMID: 22937143; PMCID: PMC3427179.
    54. Heinrichsen ET, Haddad GG. Role of high-fat diet in stress response of Drosophila. PLoS One. 2012; 7(8):e42587. PMID: 22870336; PMCID: PMC3411628.
    55. Pamenter ME, Hogg DW, Gu XQ, Buck LT, Haddad GG. Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. J Cereb Blood Flow Metab. 2012 Nov; 32(11):2033-43. PMID: 22805876; PMCID: PMC3493991.
    56. Lesser DJ, Haddad GG, Bush RA, Pian MS. The utility of a portable recording device for screening of obstructive sleep apnea in obese adolescents. J Clin Sleep Med. 2012 Jun 15; 8(3):271-7. PMID: 22701384; PMCID: PMC3365085.
    57. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, Zhou D. Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One. 2012; 7(5):e36801. PMID: 22574227; PMCID: PMC3344937.
    58. Pamenter ME, Ali SS, Tang Q, Finley JC, Gu XQ, Dugan LL, Haddad GG. An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons. Brain Res. 2012 May 03; 1452:165-72. PMID: 22459046; PMCID: PMC3326196.
    59. Zhao HW, Ali SS, Haddad GG. Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production? Antioxid Redox Signal. 2012 May 15; 16(10):1071-6. PMID: 22229946; PMCID: PMC3315163.
    60. Mittal M, Gu XQ, Pak O, Pamenter ME, Haag D, Fuchs DB, Schermuly RT, Ghofrani HA, Brandes RP, Seeger W, Grimminger F, Haddad GG, Weissmann N. Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med. 2012 Mar 15; 52(6):1033-42. PMID: 22222468.
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    61. Udpa N, Zhou D, Haddad GG, Bafna V. Tests of selection in pooled case-control data: an empirical study. Front Genet. 2011; 2:83. PMID: 22303377; PMCID: PMC3268381.
    62. Haddad GG. Does the brain gain back energy during sleep? But what does it mean? Sleep. 2011 Jul 01; 34(7):835-6. PMID: 21731130; PMCID: PMC3119555.
    63. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. PMID: 21677276; PMCID: PMC3174756.
    64. Azad P, Ryu J, Haddad GG. Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic Biol Med. 2011 Jul 15; 51(2):530-8. PMID: 21616137; PMCID: PMC3138732.
    65. Zhao HW, Haddad GG. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Placenta. 2011 Mar; 32 Suppl 2:S104-8. PMID: 21353099.
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    66. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. PMID: 21262834; PMCID: PMC3038716.
    67. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
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    68. Harrison JF, Haddad GG. Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster. Annu Rev Physiol. 2011; 73:95-113. PMID: 20936942.
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    69. Zhao HW, Zhou D, Haddad GG. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem. 2011 Feb 25; 286(8):6211-8. PMID: 21148307; PMCID: PMC3057857.
    70. Zhao HW, Zhou D, Nizet V, Haddad GG. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. PMID: 20668515; PMCID: PMC2909141.
    71. Felfly H, Muotri A, Yao H, Haddad GG. Hematopoietic stem cell transplantation protects mice from lethal stroke. Exp Neurol. 2010 Oct; 225(2):284-93. PMID: 20547154; PMCID: PMC2963425.
    72. Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad GG. Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy. Physiol Genomics. 2010 Aug; 42(3):374-83. PMID: 20460605; PMCID: PMC2929882.
    73. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. PMID: 20399150; PMCID: PMC2893150.
    74. Ryu J, Heldt GP, Nguyen M, Gavrialov O, Haddad GG. Chronic hypercapnia alters lung matrix composition in mouse pups. J Appl Physiol (1985). 2010 Jul; 109(1):203-10. PMID: 20360436; PMCID: PMC2904197.
    75. Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS. Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1594-602. PMID: 20357179; PMCID: PMC2889641.
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    182. Bkaily G, Pothier P, D'Orléans-Juste P, Simaan M, Jacques D, Jaalouk D, Belzile F, Hassan G, Boutin C, Haddad G, Neugebauer W. The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. Mol Cell Biochem. 1997 Jul; 172(1-2):171-94. PMID: 9278244.
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    183. Ma E, Haddad GG. Expression and localization of Na+/H+ exchangers in rat central nervous system. Neuroscience. 1997 Jul; 79(2):591-603. PMID: 9200742.
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    184. Chan HS, Lu Y, Grogan TM, Haddad G, Hipfner DR, Cole SP, Deeley RG, Ling V, Gallie BL. Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein. Cancer Res. 1997 Jun 15; 57(12):2325-30. PMID: 9192801.
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    185. Ma E, Haddad GG. Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. Brain Res Mol Brain Res. 1997 Jun; 46(1-2):325-8. PMID: 9191110.
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    186. HADDAD GG, WYMAN RJ, MOHSENIN A, SUN Y, KRISHNAN SN. Behavioral and Electrophysiologic Responses of Drosophila melanogaster to Prolonged Periods of Anoxia. J Insect Physiol. 1997 Mar; 43(3):203-210. PMID: 12769903.
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    187. Haddad GG. K+ ions and channels: mechanisms of sensing O2 deprivation in central neurons. Kidney Int. 1997 Feb; 51(2):467-72. PMID: 9027723.
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    188. Jiang C, Haddad GG. Modulation of K+ channels by intracellular ATP in human neocortical neurons. J Neurophysiol. 1997 Jan; 77(1):93-102. PMID: 9120601.
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    189. Marks JD, Friedman JE, Haddad GG. Vulnerability of CA1 neurons to glutamate is developmentally regulated. Brain Res Dev Brain Res. 1996 Dec 23; 97(2):194-206. PMID: 8997504.
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    190. Bevensee MO, Cummins TR, Haddad GG, Boron WF, Boyarsky G. pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats. J Physiol. 1996 Jul 15; 494 ( Pt 2):315-28. PMID: 8841993.
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    191. O'Reilly JP, Haddad GG. Chronic hypoxia in vivo renders neocortical neurons more vulnerable to subsequent acute hypoxic stress. Brain Res. 1996 Mar 04; 711(1-2):203-10. PMID: 8680864.
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    192. Bkaily G, Haddad G, Jaalouk D, Gros-Louis N, Benchekroun MT, Naik R, Pothier P, D'Orléans-Juste P, Bui M, Wang S, Sperelakis N. Modulation of Ca2+ and Na+ transport by taurine in heart and vascular smooth muscle. Adv Exp Med Biol. 1996; 403:263-73. PMID: 8915363.
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    193. Krishnan SN, Desai T, Ward DC, Haddad GG. Isolation and chromosomal localization of a human ATP-regulated potassium channel. Hum Genet. 1995 Aug; 96(2):155-60. PMID: 7635463.
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    194. O'Reilly JP, Jiang C, Haddad GG. Major differences in response to graded hypoxia between hypoglossal and neocortical neurons. Brain Res. 1995 Jun 19; 683(2):179-86. PMID: 7552353.
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    195. Xia Y, Warshaw JB, Haddad GG. Chronic hypoxia causes opposite effects on glucose transporter 1 mRNA in mature versus immature rat brain. Brain Res. 1995 Mar 27; 675(1-2):224-30. PMID: 7796133.
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    196. Jiang C, Haddad GG. Oxygen deprivation inhibits a K+ channel independently of cytosolic factors in rat central neurons. J Physiol. 1994 Nov 15; 481 ( Pt 1):15-26. PMID: 7853238.
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    197. Friedman JE, Haddad GG. Anoxia induces an increase in intracellular sodium in rat central neurons in vitro. Brain Res. 1994 Nov 14; 663(2):329-34. PMID: 7874519.
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    198. Jiang C, Sigworth FJ, Haddad GG. Oxygen deprivation activates an ATP-inhibitable K+ channel in substantia nigra neurons. J Neurosci. 1994 Sep; 14(9):5590-602. PMID: 8083755.
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    199. Jiang C, Haddad GG. A direct mechanism for sensing low oxygen levels by central neurons. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7198-201. PMID: 8041769.
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    200. Xia Y, Haddad GG. Postnatal development of voltage-sensitive Na+ channels in rat brain. J Comp Neurol. 1994 Jul 08; 345(2):279-87. PMID: 7929902.
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    201. Friedman JE, Haddad GG. Removal of extracellular sodium prevents anoxia-induced injury in freshly dissociated rat CA1 hippocampal neurons. Brain Res. 1994 Mar 28; 641(1):57-64. PMID: 8019852.
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    202. Cummins TR, Xia Y, Haddad GG. Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol. 1994 Mar; 71(3):1052-64. PMID: 8201401.
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    203. Xia Y, Haddad GG. Voltage-sensitive Na+ channels increase in number in newborn rat brain after in utero hypoxia. Brain Res. 1994 Jan 28; 635(1-2):339-44. PMID: 8173974.
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    204. Haddad GG, Jiang C. Mechanisms of neuronal survival during hypoxia: ATP-sensitive K+ channels. Biol Neonate. 1994; 65(3-4):160-5. PMID: 8038277.
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    205. Jiang C, Cummins TR, Haddad GG. Membrane ionic currents and properties of freshly dissociated rat brainstem neurons. Exp Brain Res. 1994; 100(3):407-20. PMID: 7813679.
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    206. D'Andrea LA, Rosen CL, Haddad GG. Severe hypoxemia in children with upper airway obstruction during sleep does not lead to significant changes in heart rate. Pediatr Pulmonol. 1993 Dec; 16(6):362-9. PMID: 8134159.
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    207. Xia Y, Eisenman D, Haddad GG. Sulfonylurea receptor expression in rat brain: effect of chronic hypoxia during development. Pediatr Res. 1993 Nov; 34(5):634-41. PMID: 8284102.
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    208. Haddad GG, Jiang C. Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat. Brain Res. 1993 Oct 22; 625(2):261-8. PMID: 7903900.
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    209. Kwei S, Jiang C, Haddad GG. Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal morphology in rat hippocampus. Brain Res. 1993 Aug 27; 620(2):203-10. PMID: 8369956.
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    210. Jiang C, Haddad GG. Short periods of hypoxia activate a K+ current in central neurons. Brain Res. 1993 Jun 18; 614(1-2):352-6. PMID: 8348327.
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    211. Xia Y, Haddad GG. Neuroanatomical distribution and binding properties of saxitoxin sites in the rat and turtle CNS. J Comp Neurol. 1993 Apr 15; 330(3):363-80. PMID: 8468412.
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    212. Young RS, During MJ, Donnelly DF, Aquila WJ, Perry VL, Haddad GG. Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis. Am J Physiol. 1993 Apr; 264(4 Pt 2):R716-9. PMID: 8097385.
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    213. Haddad GG, Jiang C. O2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol. 1993 Mar; 40(3):277-318. PMID: 7680137.
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    214. Cummins TR, Agulian SK, Haddad GG. Oxygen tension clamp around single neurons in vitro: a computerized method for studies on O2 deprivation. J Neurosci Methods. 1993 Mar; 46(3):183-9. PMID: 8483311.
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    215. Rosen CL, Schecter WS, Mellins RB, Haddad GG. Effect of acute hypoxia on metabolism and ventilation in awake piglets. Respir Physiol. 1993 Mar; 91(2-3):307-19. PMID: 8469853.
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    216. Cummins TR, Jiang C, Haddad GG. Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest. 1993 Feb; 91(2):608-15. PMID: 8381823.
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    217. Friedman JE, Haddad GG. Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o. J Neurosci. 1993 Jan; 13(1):63-72. PMID: 8093716.
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    218. Jiang C, Haddad GG. Differential responses of neocortical neurons to glucose and/or O2 deprivation in the human and rat. J Neurophysiol. 1992 Dec; 68(6):2165-73. PMID: 1491265.
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    219. Rosen CL, D'Andrea L, Haddad GG. Adult criteria for obstructive sleep apnea do not identify children with serious obstruction. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1231-4. PMID: 1443876.
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    220. Sanocka UM, Donnelly DF, Haddad GG. Autoresuscitation: a survival mechanism in piglets. J Appl Physiol (1985). 1992 Aug; 73(2):749-53. PMID: 1400005.
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    221. Xia Y, Haddad GG. Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain regions. Neuroscience. 1992 Aug; 49(4):973-89. PMID: 1331860.
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    222. Donnelly DF, Jiang C, Haddad GG. Comparative responses of brain stem and hippocampal neurons to O2 deprivation: in vitro intracellular studies. Am J Physiol. 1992 May; 262(5 Pt 1):L549-54. PMID: 1590406.
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    223. Xia Y, Jiang C, Haddad GG. Oxidative and glycolytic pathways in rat (newborn and adult) and turtle brain: role during anoxia. Am J Physiol. 1992 Apr; 262(4 Pt 2):R595-603. PMID: 1314516.
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    224. Jiang C, Xia Y, Haddad GG. Role of ATP-sensitive K+ channels during anoxia: major differences between rat (newborn and adult) and turtle neurons. J Physiol. 1992 Mar; 448:599-612. PMID: 1593480.
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    225. Jiang C, Agulian S, Haddad GG. Cl- and Na+ homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies. J Physiol. 1992 Mar; 448:697-708. PMID: 1593484.
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    226. Jiang C, Agulian S, Haddad GG. O2 tension in adult and neonatal brain slices under several experimental conditions. Brain Res. 1991 Dec 24; 568(1-2):159-64. PMID: 1814564.
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    227. Xia Y, Haddad GG. Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle. J Comp Neurol. 1991 Dec 08; 314(2):278-89. PMID: 1787178.
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    228. Cummins TR, Donnelly DF, Haddad GG. Effect of metabolic inhibition on the excitability of isolated hippocampal CA1 neurons: developmental aspects. J Neurophysiol. 1991 Nov; 66(5):1471-82. PMID: 1662712.
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    229. Chan HS, Thorner PS, Haddad G, Gallie BL. Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression. Ophthalmology. 1991 Sep; 98(9):1425-31. PMID: 1682862.
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    230. Feldman JD, Bazzy AR, Cummins TR, Haddad GG. Developmental changes in neuromuscular transmission in the rat diaphragm. J Appl Physiol (1985). 1991 Jul; 71(1):280-6. PMID: 1655690.
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    231. Jiang C, Haddad GG. Effect of anoxia on intracellular and extracellular potassium activity in hypoglossal neurons in vitro. J Neurophysiol. 1991 Jul; 66(1):103-11. PMID: 1919660.
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    232. Xia Y, Haddad GG. Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res. 1991 May 24; 549(2):181-93. PMID: 1653081.
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    233. Haddad GG, Donnelly DF. O2 deprivation induces a major depolarization in brain stem neurons in the adult but not in the neonatal rat. J Physiol. 1990 Oct; 429:411-28. PMID: 2126043.
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    234. Haddad GG, Donnelly DF, Getting PA. Biophysical properties of hypoglossal neurons in vitro: intracellular studies in adult and neonatal rats. J Appl Physiol (1985). 1990 Oct; 69(4):1509-17. PMID: 2262474.
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    235. Dekin MS, Haddad GG. Membrane and cellular properties in oscillating networks: implications for respiration. J Appl Physiol (1985). 1990 Sep; 69(3):809-21. PMID: 2246168.
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    236. Cote A, Haddad GG. Effect of sleep on regional blood flow distribution in piglets. Pediatr Res. 1990 Sep; 28(3):218-22. PMID: 2235117.
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    237. Donnelly DF, Haddad GG. Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section. J Appl Physiol (1985). 1990 Mar; 68(3):1048-52. PMID: 2341332.
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    238. Haddad GG, Getting PA. Repetitive firing properties of neurons in the ventral region of nucleus tractus solitarius. In vitro studies in adult and neonatal rat. J Neurophysiol. 1989 Dec; 62(6):1213-24. PMID: 2600620.
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    239. Singh M, Rosen CL, Chang KJ, Haddad GG. Plasma beta-casomorphin-7 immunoreactive peptide increases after milk intake in newborn but not in adult dogs. Pediatr Res. 1989 Jul; 26(1):34-8. PMID: 2771507.
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    240. Rosen CL, Cote A, Haddad GG. Effect of enkephalins on cardiac output and regional blood flow in conscious dogs. Am J Physiol. 1989 Jun; 256(6 Pt 2):H1651-8. PMID: 2500032.
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    241. Bazzy AR, Pang LM, Akabas SR, Haddad GG. O2 metabolism of the sheep diaphragm during flow resistive loaded breathing. J Appl Physiol (1985). 1989 May; 66(5):2305-11. PMID: 2745294.
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    242. Akabas SR, Bazzy AR, DiMauro S, Haddad GG. Metabolic and functional adaptation of the diaphragm to training with resistive loads. J Appl Physiol (1985). 1989 Feb; 66(2):529-35. PMID: 2540138.
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    243. Schaeffer JI, Haddad GG. Ventilatory response to moderate and severe hypoxia in adult dogs: role of endorphins. J Appl Physiol (1985). 1988 Sep; 65(3):1383-8. PMID: 3141354.
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    244. Bazzy AR, Akabas SR, Hays AP, Haddad GG. Respiratory muscle response to load and glycogen content in type I and II fibers. Exp Neurol. 1988 Jul; 101(1):17-28. PMID: 3391257.
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    245. Sanocka UM, Donnelly DF, Haddad GG. Cardiovascular and neurophysiologic changes during graded duration of apnea in piglets. Pediatr Res. 1988 Apr; 23(4):402-7. PMID: 3374994.
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    246. Haddad GG, Jeng HJ, Lai TL. Heart rate variability during respiratory pauses in puppies and dogs. Pediatr Res. 1987 Sep; 22(3):306-11. PMID: 3658551.
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    247. Haddad GG, Jeng HJ, Lai TL, Mellins RB. Determination of sleep state in infants using respiratory variability. Pediatr Res. 1987 Jun; 21(6):556-62. PMID: 3601474.
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    248. Haddad GG, Jeng HJ, Bazzy AR, Lai TL. Within-breath electromyographic changes during loaded breathing in adult sheep. J Appl Physiol (1985). 1986 Oct; 61(4):1316-21. PMID: 3781946.
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    249. Bazzy AR, Korten JB, Haddad GG. Increase in electromyogram low-frequency power in nonfatigued contracting skeletal muscle. J Appl Physiol (1985). 1986 Sep; 61(3):1012-7. PMID: 3759739.
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    250. Donnelly DF, Haddad GG. Respiratory changes induced by prolonged laryngeal stimulation in awake piglets. J Appl Physiol (1985). 1986 Sep; 61(3):1018-24. PMID: 3759740.
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    251. Schaeffer JI, Haddad GG. Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists. J Appl Physiol (1985). 1985 Sep; 59(3):959-68. PMID: 2997105.
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    252. Sadoul N, Bazzy AR, Akabas SR, Haddad GG. Ventilatory response to fatiguing and nonfatiguing resistive loads in awake sheep. J Appl Physiol (1985). 1985 Sep; 59(3):969-78. PMID: 4055582.
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    253. Haddad GG, Schaeffer JI, Chang KJ. Opposite effects of the delta- and mu-opioid receptor agonists on ventilation in conscious adult dogs. Brain Res. 1984 Dec 03; 323(1):73-82. PMID: 6098337.
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    254. Mellins RB, Haddad GG. Cardiorespiratory control in sudden infant death syndrome. Prog Clin Biol Res. 1983; 136:51-7. PMID: 6420807.
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    255. Mellins RB, Haddad GG. Respiratory control in early life: an overview. Prog Clin Biol Res. 1983; 136:3-15. PMID: 6364172.
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    256. Haddad GG, Gandhi MR, Mellins RB. Maturation of ventilatory response to hypoxia in puppies during sleep. J Appl Physiol Respir Environ Exerc Physiol. 1982 Feb; 52(2):309-14. PMID: 7061286.
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    257. Haddad GG, Walsh EM, Leistner HL, Grodin WK, Mellins RB. Abnormal maturation of sleep states in infants with aborted sudden infant death syndrome. Pediatr Res. 1981 Jul; 15(7):1055-7. PMID: 7254951.
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    258. Haddad GG, Leistner HL, Lai TL, Mellins RB. Ventilation and ventilatory pattern during sleep in aborted sudden infant death syndrome. Pediatr Res. 1981 May; 15(5):879-83. PMID: 6787545.
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    259. Haddad GG, Epstein RA, Epstein MA, Leistner HL, Mellins RB. The R-R interval and R-R variability in normal infants during sleep. Pediatr Res. 1980 Jun; 14(6):809-11. PMID: 7402755.
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    260. Haddad GG, Leistner HL, Epstein RA, Epstein MA, Grodin WK, Mellins RB. CO2-induced changes in ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr; 48(4):684-8. PMID: 6769883.
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    261. Mazza NM, Epstein MA, Haddad GG, Law HS, Mellins RB, Epstein RA. Relation of beat-to-beat variability to heart rate in normal sleeping infants. Pediatr Res. 1980 Mar; 14(3):232-5. PMID: 7383743.
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    262. Haddad GG, Krongrad E, Epstein RA, Epstein MA, Law HS, Katz JB, Mazza NM, Mellins RB. Effect of sleep state on the QT interval in normal infants. Pediatr Res. 1979 Feb; 13(2):139-41. PMID: 219413.
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    263. Haddad GG, Epstein MA, Epstein RA, Mazza NM, Mellins RB, Krongrad E. The QT interval in aborted sudden infant death syndrome infants. Pediatr Res. 1979 Feb; 13(2):136-8. PMID: 219412.
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    264. Haddad GG, Mellins RB. The role of airway receptors in the control of respiration in infants: a review. J Pediatr. 1977 Aug; 91(2):281-6. PMID: 874688.
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    265. Armstrong RW, Arkayin B, Haddad G. Fracture of bone materials in compression at temperatures between -200 degree C and +200 degree C. Nature. 1971 Aug 20; 232(5312):576-7. PMID: 4937508.
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