Boyle, David

TitleProfessor of Medicine
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0656
La Jolla CA 92093
vCardDownload vCard
    Other Positions
    TitleCo-Director, Translational Research Technology, Clinical and Translational Research Institute (CTRI)

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Ai R, Laragione T, Hammaker D, Boyle D, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat Commun. 2018 May 15; 9(1):1921. PMID: 29765031.
      View in: PubMed
    2. Nygaard G, Di Paolo JA, Hammaker D, Boyle D, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018 May; 151:282-290. PMID: 29408488.
      View in: PubMed
    3. Orr C, Vieira-Sousa E, Boyle D, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Goff BL, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Tas SW, Thurlings R, Fonseca JE, Veale DJ. Corrigendum: Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 Dec 19; 14(1):60. PMID: 29255214.
      View in: PubMed
    4. Orr C, Vieira-Sousa E, Boyle D, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ. Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 Sep 22; 13(10):630. PMID: 28935945.
      View in: PubMed
    5. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle D, Dowdy S, Wang W, Firestein GS. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 10 01; 199(7):2316-2322. PMID: 28807995.
      View in: PubMed
    6. Orr C, Vieira-Sousa E, Boyle D, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ, Tas SW. Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 08; 13(8):463-475. PMID: 28701760.
      View in: PubMed
    7. Hammaker D, Whitaker JW, Maeshima K, Boyle D, Ekwall AH, Wang W, Firestein GS. LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis. Arthritis Rheumatol. 2016 11; 68(11):2637-2645. PMID: 27159840.
      View in: PubMed
    8. Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open. 2016; 2(2):e000289. PMID: 27651926; PMCID: PMC5013418.
    9. Ai R, Hammaker D, Boyle D, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W. Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat Commun. 2016 Jun 10; 7:11849. PMID: 27282753; PMCID: PMC4906396.
    10. Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle D, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). PMID: 27275015.
      View in: PubMed
    11. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle D, Corr M, Firestein GS, Bottini N. Receptor Protein Tyrosine Phosphatase a-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69. PMID: 26414708; PMCID: PMC4770259 [Available on 02/01/17].
    12. Buckley N, Boyle D, McArt D, Irwin G, Harkin DP, Lioe T, McQuaid S, James JA, Maxwell P, Hamilton P, Mullan PB, Salto-Tellez M. Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention. Oncotarget. 2015 Dec 22; 6(41):43244-54. PMID: 26657114; PMCID: PMC4791229.
    13. Whitaker JW, Boyle D, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets. PLoS One. 2015; 10(8):e0136334. PMID: 26288175; PMCID: PMC4544850.
    14. Ai R, Whitaker JW, Boyle D, Tak PP, Gerlag DM, Wang W, Firestein GS. DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul; 67(7):1978-80. PMID: 25808728; PMCID: PMC4485541.
    15. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle D, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. PMID: 25995222.
      View in: PubMed
    16. Whitaker JW, Boyle D, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets. PLoS One. 2015; 10(4):e0124254. PMID: 25901943; PMCID: PMC4406750.
    17. Boland BS, Boyle D, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. PMID: 25545378; PMCID: PMC4404151.
    18. Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle D, Firestein GS, Bottini N. TGFß responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302. PMID: 25378349.
      View in: PubMed
    19. Gong W, Kolker SJ, Usachev Y, Walder RY, Boyle D, Firestein GS, Sluka KA. Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther. 2014 Jun 12; 16(3):R121. PMID: 24923411; PMCID: PMC4095605.
    20. Hammaker D, Boyle D, Topolewski K, Firestein GS. Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. J Inflamm (Lond). 2014; 11:14. PMID: 24855454; PMCID: PMC4030013.
    21. Jones JD, Hamilton BJ, Challener GJ, de Brum-Fernandes AJ, Cossette P, Liang P, Masetto A, Ménard HA, Carrier N, Boyle D, Rosengren S, Boire G, Rigby WF. Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels. Arthritis Res Ther. 2014 Apr 25; 16(2):R103. PMID: 24766912; PMCID: PMC4060390.
    22. D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB. TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities. Oncotarget. 2014 Mar 30; 5(6):1609-20. PMID: 24742492; PMCID: PMC4057604.
    23. Leinders M, Koehrn FJ, Bartok B, Boyle D, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-60. PMID: 24631588; PMCID: PMC4128246.
    24. Boyle D, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS. Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One. 2014; 9(1):e84818. PMID: 24400116; PMCID: PMC3882259.
    25. Boyle D, Kim HR, Topolewski K, Bartok B, Firestein GS. Novel phosphoinositide 3-kinase d,? inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):271-80. PMID: 24244039.
      View in: PubMed
    26. Sluka KA, Rasmussen LA, Edgar MM, O'Donnell JM, Walder RY, Kolker SJ, Boyle D, Firestein GS. Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum. 2013 May; 65(5):1194-202. PMID: 23335302; PMCID: PMC3636153.
    27. Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle D, Arnett HA, Mustelin T, Firestein GS, Bottini N. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80. PMID: 23335101; PMCID: PMC3636201.
    28. Whitaker JW, Shoemaker R, Boyle D, Hillman J, Anderson D, Wang W, Firestein GS. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med. 2013; 5(4):40. PMID: 23631487; PMCID: PMC3706831.
    29. Nakano K, Boyle D, Firestein GS. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol. 2013 Feb 01; 190(3):1297-303. PMID: 23277489; PMCID: PMC3552038.
    30. Guma M, Hammaker D, Topolewski K, Corr M, Boyle D, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549; PMCID: PMC3397277.
    31. Nakano K, Whitaker JW, Boyle D, Wang W, Firestein GS. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013 Jan; 72(1):110-7. PMID: 22736089; PMCID: PMC3549371.
    32. Bartok B, Boyle D, Liu Y, Ren P, Ball ST, Bugbee WD, Rommel C, Firestein GS. PI3 kinase d is a key regulator of synoviocyte function in rheumatoid arthritis. Am J Pathol. 2012 May; 180(5):1906-16. PMID: 22433439.
      View in: PubMed
    33. Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle D, Burak EC, Sah RL, Firestein GS. Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice. Arthritis Rheum. 2012 Mar; 64(3):678-87. PMID: 21953132; PMCID: PMC3267851.
    34. Lee SI, Boyle D, Berdeja A, Firestein GS. Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway. Arthritis Res Ther. 2012 Feb 21; 14(1):R38. PMID: 22353730; PMCID: PMC3392838.
    35. Rosengren S, Corr M, Firestein GS, Boyle D. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis. 2012 Mar; 71(3):440-7. PMID: 22121136.
      View in: PubMed
    36. Rosengren S, Kalunian KC, Kavanaugh A, Boyle D. CXCL13 as a marker for outcome of rheumatoid arthritis: comment on the article by Meeuwisse et al. Arthritis Rheum. 2011 Nov; 63(11):3646-7. PMID: 21834069.
      View in: PubMed
    37. Luo Y, Boyle D, Hammaker D, Edgar M, Franzoso G, Firestein GS. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45ß-deficient mice. Arthritis Rheum. 2011 Oct; 63(10):2949-55. PMID: 21702006; PMCID: PMC3183142.
    38. Hammaker D, Boyle D, Firestein GS. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology (Oxford). 2012 Apr; 51(4):610-8. PMID: 21613249; PMCID: PMC3306173.
    39. Gubala A, Davis S, Weir R, Melville L, Cowled C, Boyle D. Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization, evolution of novel genes and seroprevalence in Australian livestock. J Gen Virol. 2011 Sep; 92(Pt 9):2160-70. PMID: 21593274.
      View in: PubMed
    40. Corr M, Boyle D, Ronacher LM, Lew BR, van Baarsen LG, Tak PP, Firestein GS. Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis. Ann Rheum Dis. 2011 May; 70(5):858-63. PMID: 21216819; PMCID: PMC3728888.
    41. Rosengren S, Wei N, Kalunian KC, Kavanaugh A, Boyle D. CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis. Rheumatology (Oxford). 2011 Mar; 50(3):603-10. PMID: 21098574.
      View in: PubMed
    42. Toh ML, Gonzales G, Koenders MI, Tournadre A, Boyle D, Lubberts E, Zhou Y, Firestein GS, van den Berg WB, Miossec P. Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression. PLoS One. 2010 Oct 15; 5(10):e13416. PMID: 20976214; PMCID: PMC2955522.
    43. Rosengren S, Corr M, Boyle D. Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res Ther. 2010; 12(2):R65. PMID: 20380722; PMCID: PMC2888219.
    44. Auci DL, Mangano K, Destiche D, White SK, Huang Y, Boyle D, Frincke J, Reading CL, Nicoletti F. Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis. Int J Mol Med. 2010 Apr; 25(4):625-33. PMID: 20198312.
      View in: PubMed
    45. Chao J, Wu C, Sun B, Hose MK, Quan A, Hughes TH, Boyle D, Kalunian KC. Inflammatory characteristics on ultrasound predict poorer longterm response to intraarticular corticosteroid injections in knee osteoarthritis. J Rheumatol. 2010 Mar; 37(3):650-5. PMID: 20080918.
      View in: PubMed
    46. Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle D, Firestein GS. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40. PMID: 19877043; PMCID: PMC2858378.
    47. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle D, Corr M, Kono DH, Silverman GJ. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. PMID: 19564341; PMCID: PMC2713016.
    48. Yoshizawa T, Hammaker D, Boyle D, Corr M, Flavell R, Davis R, Schett G, Firestein GS. Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression. J Immunol. 2009 Jul 15; 183(2):1360-7. PMID: 19561096; PMCID: PMC2744479.
    49. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle D, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009 Jun 19; 30(6):875-87. PMID: 19501000; PMCID: PMC2759865.
    50. Fukushima A, Boyle D, Corr M, Firestein GS. Kinetic analysis of synovial signalling and gene expression in animal models of arthritis. Ann Rheum Dis. 2010 May; 69(5):918-23. PMID: 19473996; PMCID: PMC2859101.
    51. Offner H, Firestein GS, Boyle D, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL. An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009 Jun; 329(3):1100-9. PMID: 19297421.
      View in: PubMed
    52. Cowled C, Palacios G, Melville L, Weir R, Walsh S, Davis S, Gubala A, Lipkin WI, Briese T, Boyle D. Genetic and epidemiological characterization of Stretch Lagoon orbivirus, a novel orbivirus isolated from Culex and Aedes mosquitoes in northern Australia. J Gen Virol. 2009 Jun; 90(Pt 6):1433-9. PMID: 19282430; PMCID: PMC2887561.
    53. Waldburger JM, Boyle D, Pavlov VA, Tracey KJ, Firestein GS. Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum. 2008 Nov; 58(11):3439-49. PMID: 18975306; PMCID: PMC4476299.
    54. Yoshizawa T, Hammaker D, Sweeney SE, Boyle D, Firestein GS. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. J Immunol. 2008 Sep 01; 181(5):3252-8. PMID: 18713996; PMCID: PMC2725405.
    55. Waldburger JM, Boyle D, Edgar M, Sorkin LS, Levine YA, Pavlov VA, Tracey K, Firestein GS. Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21. PMID: 18759350; PMCID: PMC4533855.
    56. Rosengren S, Wei N, Kalunian KC, Zvaifler NJ, Kavanaugh A, Boyle D. Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab. Arthritis Res Ther. 2008; 10(5):R105. PMID: 18761748; PMCID: PMC2592782.
    57. Boyle D, Kavanaugh A. The pathobiology of psoriatic synovium. Curr Opin Rheumatol. 2008 Jul; 20(4):404-7. PMID: 18525352.
      View in: PubMed
    58. Silverman GJ, Boyle D. Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev. 2008 Jun; 223:175-85. PMID: 18613836.
      View in: PubMed
    59. Cheung WW, Rosengren S, Boyle D, Mak RH. Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney Int. 2008 Jul; 74(2):180-6. PMID: 18432186.
      View in: PubMed
    60. Cowled C, Melville L, Weir R, Walsh S, Hyatt A, Van Driel R, Davis S, Gubala A, Boyle D. Genetic and epidemiological characterization of Middle Point orbivirus, a novel virus isolated from sentinel cattle in northern Australia. J Gen Virol. 2007 Dec; 88(Pt 12):3413-22. PMID: 18024911.
      View in: PubMed
    61. Sun Y, Firestein G, Boyle D, Gruber H, Cheung H. Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern. J Rheumatol. 2007 Oct; 34(10):1959-70. PMID: 17896808.
      View in: PubMed
    62. Oliver SJ, Firestein GS, Arsenault L, Cruz TF, Cheng TP, Banquerigo ML, Boyle D, Brahn E. Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis. J Rheumatol. 2007 Sep; 34(9):1802-9. PMID: 17696279.
      View in: PubMed
    63. Goodyear CS, Corr M, Sugiyama F, Boyle D, Silverman GJ. Cutting Edge: Bim is required for superantigen-mediated B cell death. J Immunol. 2007 Mar 01; 178(5):2636-40. PMID: 17312102.
      View in: PubMed
    64. Bresnihan B, Gerlag DM, Rooney T, Smeets TJ, Wijbrandts CA, Boyle D, Fitzgerald O, Kirkham BW, McInnes IB, Smith M, Ulfgren AK, Veale DJ, Tak PP. Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J Rheumatol. 2007 Mar; 34(3):620-2. PMID: 17343309.
      View in: PubMed
    65. Rosengren S, Mueller JL, Anderson JP, Niehaus BL, Misaghi A, Anderson S, Boyle D, Hoffman HM. Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol. 2007 Apr; 119(4):991-6. PMID: 17320940; PMCID: PMC4322003.
    66. Rosengren S, Boyle D, Firestein GS. Acquisition, culture, and phenotyping of synovial fibroblasts. Methods Mol Med. 2007; 135:365-75. PMID: 17951672.
      View in: PubMed
    67. Hammaker DR, Boyle D, Inoue T, Firestein GS. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2007; 9(3):R57. PMID: 17559674; PMCID: PMC2206340.
    68. Gerlag DM, Boyle D, Rosengren S, Nash T, Tak PP, Firestein GS. Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment. Ann Rheum Dis. 2007 Apr; 66(4):545-7. PMID: 16984938; PMCID: PMC1856037.
    69. Boyle D, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. PMID: 16953659; PMCID: PMC1560929.
    70. Inoue T, Hammaker D, Boyle D, Firestein GS. Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Jul; 54(7):2127-35. PMID: 16802349.
      View in: PubMed
    71. Inoue T, Boyle D, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5484-9. PMID: 16567640; PMCID: PMC1459381.
    72. Cha HS, Boyle D, Inoue T, Schoot R, Tak PP, Pine P, Firestein GS. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May; 317(2):571-8. PMID: 16452391.
      View in: PubMed
    73. Cha HS, Rosengren S, Boyle D, Firestein GS. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Feb; 54(2):587-92. PMID: 16447235.
      View in: PubMed
    74. You X, Boyle D, Hammaker D, Firestein GS. PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53. Arthritis Res Ther. 2006; 8(6):R157. PMID: 17014719; PMCID: PMC1794498.
    75. Genovese MC, Chakravarty EF, Boyle D, Tutuncu Z, Thorburn CM, Halilhodzic M, Kroll S, Baughman J, Stewart S, Kavanaugh A. A randomized, blinded, parallel group, placebo controlled pilot study evaluating the effect of PVAC treatment in patients with diffuse systemic sclerosis. J Rheumatol. 2005 Dec; 32(12):2345-50. PMID: 16331761.
      View in: PubMed
    76. Tutuncu Z, Kavanaugh A, Zvaifler N, Corr M, Deutsch R, Boyle D. Fcgamma receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor alpha-blocking agents. Arthritis Rheum. 2005 Sep; 52(9):2693-6. PMID: 16142749.
      View in: PubMed
    77. Simelyte E, Rosengren S, Boyle D, Corr M, Green DR, Firestein GS. Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum. 2005 Jun; 52(6):1876-84. PMID: 15934085.
      View in: PubMed
    78. Sweeney SE, Hammaker D, Boyle D, Firestein GS. Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. J Immunol. 2005 May 15; 174(10):6424-30. PMID: 15879144.
      View in: PubMed
    79. Cardoso M, Hyatt A, Selleck P, Lowther S, Prakash V, Pain D, Cunningham AA, Boyle D. Phylogenetic analysis of the DNA polymerase gene of a novel alphaherpesvirus isolated from an Indian Gyps vulture. Virus Genes. 2005 May; 30(3):371-81. PMID: 15830156.
      View in: PubMed
    80. Inoue T, Hammaker D, Boyle D, Firestein GS. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J Immunol. 2005 Apr 01; 174(7):4301-6. PMID: 15778394.
      View in: PubMed
    81. Ohata J, Zvaifler NJ, Nishio M, Boyle D, Kalled SL, Carson DA, Kipps TJ. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005 Jan 15; 174(2):864-70. PMID: 15634908.
      View in: PubMed
    82. Cheon H, Boyle D, Firestein GS. Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. J Rheumatol. 2004 Nov; 31(11):2106-14. PMID: 15517620.
      View in: PubMed
    83. Hoffman HM, Rosengren S, Boyle D, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. PMID: 15541451; PMCID: PMC4321997.
    84. Yamanishi Y, Boyle D, Green DR, Keystone EC, Connor A, Zollman S, Firestein GS. p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther. 2005; 7(1):R12-8. PMID: 15642132; PMCID: PMC1064878.
    85. Anderson JP, Mueller JL, Rosengren S, Boyle D, Schaner P, Cannon SB, Goodyear CS, Hoffman HM. Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18; 338(1):25-34. PMID: 15302403; PMCID: PMC4348074.
    86. Hammaker DR, Boyle D, Chabaud-Riou M, Firestein GS. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol. 2004 Feb 01; 172(3):1612-8. PMID: 14734742.
      View in: PubMed
    87. Rosengren S, Firestein GS, Boyle D. Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2003 Nov; 10(6):1002-10. PMID: 14607859; PMCID: PMC262451.
    88. Sorkin LS, Moore J, Boyle D, Yang L, Firestein GS. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8. PMID: 14637089.
      View in: PubMed
    89. Boyle D, Rosengren S, Bugbee W, Kavanaugh A, Firestein GS. Quantitative biomarker analysis of synovial gene expression by real-time PCR. Arthritis Res Ther. 2003; 5(6):R352-60. PMID: 14680510; PMCID: PMC333415.
    90. Sundarrajan M, Boyle D, Chabaud-Riou M, Hammaker D, Firestein GS. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum. 2003 Sep; 48(9):2450-60. PMID: 13130464.
      View in: PubMed
    91. Sorkin LS, Maruyama K, Boyle D, Yang L, Marsala M, Firestein GS. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. PMID: 12668251.
      View in: PubMed
    92. Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle D, Firestein GS. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003 Feb 15; 170(4):2214-20. PMID: 12574395.
      View in: PubMed
    93. Boyle D, Moore J, Yang L, Sorkin LS, Firestein GS. Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82. PMID: 12428252.
      View in: PubMed
    94. Yamanishi Y, Boyle D, Rosengren S, Green DR, Zvaifler NJ, Firestein GS. Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10025-30. PMID: 12119414; PMCID: PMC126618.
    95. Yamanishi Y, Boyle D, Clark M, Maki RA, Tortorella MD, Arner EC, Firestein GS. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol. 2002 Feb 01; 168(3):1405-12. PMID: 11801682.
      View in: PubMed
    96. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. PMID: 11751945.
      View in: PubMed
    97. Yamanishi Y, Boyle D, Pinkoski MJ, Mahboubi A, Lin T, Han Z, Zvaifler NJ, Green DR, Firestein GS. Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol. 2002 Jan; 160(1):123-30. PMID: 11786406; PMCID: PMC1867134.