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Boyle, David

Title(s)Professor of Medicine, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0656
La Jolla CA 92093
Phone858-822-0784
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    Other Positions
    Title(s)Co-Director, Translational Research Technology, Clinical and Translational Research Institute (CTRI)


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity. Inflamm Bowel Dis. 2020 Oct 07. Fang X, Vázquez-Baeza Y, Elijah E, Vargas F, Ackermann G, Humphrey G, Lau R, Weldon KC, Sanders JG, Panitchpakdi M, Carpenter C, Jarmusch AK, Neill J, Miralles A, Dulai P, Singh S, Tsai M, Swafford AD, Smarr L, Boyle DL, Palsson BO, Chang JT, Dorrestein PC, Sandborn WJ, Knight R, Boland BS. PMID: 33026068.
      View in: PubMed   Mentions:    Fields:    
    2. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal. Sci Adv. 2020 Jun; 6(26):eaba4353. Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N. PMID: 32637608.
      View in: PubMed   Mentions:    Fields:    
    3. Differential DNA Methylation of Networked Signaling, Transcriptional, Innate and Adaptive Immunity, and Osteoclastogenesis Genes and Pathways in Gout. Arthritis Rheumatol. 2020 05; 72(5):802-814. Wang Z, Zhao Y, Phipps-Green A, Liu-Bryan R, Ceponis A, Boyle DL, Wang J, Merriman TR, Wang W, Terkeltaub R. PMID: 31738005.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Development of gut-selective pan-Janus kinase inhibitor TD-1473 for ulcerative colitis: A translational medicine program. J Crohns Colitis. 2020 Mar 11. Sandborn WJ, Nguyen DD, Beattie DT, Brassil P, Krey W, Woo J, Situ E, Sana R, Sandvik E, Pulido-Rios MT, Bhandari R, Leighton JA, Ganeshappa R, Boyle DL, Abhyankar B, Kleinschek MA, Graham RA, Panes J. PMID: 32161949.
      View in: PubMed   Mentions:    Fields:    
    5. Correlation of serum protein biomarkers with disease activity in psoriatic arthritis. Expert Rev Clin Immunol. 2020 Mar; 16(3):335-341. Boyd TA, Eastman PS, Huynh DH, Qureshi F, Sasso EH, Bolce R, Temple J, Hillman J, Boyle DL, Kavanaugh A. PMID: 32067517.
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    6. Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis Fibroblast-like Synoviocytes. ACR Open Rheumatol. 2019 Dec; 1(10):640-648. Hammaker D, Nygaard G, Kuhs A, Ai R, Boyle DL, Wang W, Firestein GS. PMID: 31872186.
      View in: PubMed   Mentions:
    7. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 07; 20(7):928-942. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. PMID: 31061532.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    8. PTPN14 phosphatase and YAP promote TGFß signalling in rheumatoid synoviocytes. Ann Rheum Dis. 2019 05; 78(5):600-609. Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. PMID: 30808624.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study. Inflamm Res. 2019 Apr; 68(4):261-274. Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL. PMID: 30739130.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    10. Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis. Arthritis Res Ther. 2018 08 03; 20(1):164. Narasimhan R, Coras R, Rosenthal SB, Sweeney SR, Lodi A, Tiziani S, Boyle D, Kavanaugh A, Guma M. PMID: 30075744.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue Arthritis Res Ther. 2018 07 11; 20(1):139. Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. PMID: 29996944.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    12. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes. Nat Commun. 2018 05 15; 9(1):1921. Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS. PMID: 29765031.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis. Biochem Pharmacol. 2018 05; 151:282-290. Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS. PMID: 29408488.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Corrigendum: Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 Dec 19; 14(1):60. Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Goff BL, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Tas SW, Thurlings R, Fonseca JE, Veale DJ. PMID: 29255214.
      View in: PubMed   Mentions: 1     Fields:    
    15. Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 Sep 22; 13(10):630. Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ. PMID: 28935945.
      View in: PubMed   Mentions: 5     Fields:    
    16. Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene. J Immunol. 2017 10 01; 199(7):2316-2322. Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS. PMID: 28807995.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol. 2017 08; 13(8):463-475. Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ, Tas SW. PMID: 28701760.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    18. "TORNADO" - Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid. Sci Rep. 2017 05 11; 7(1):1750. McArdle H, Jimenez-Mateos EM, Raoof R, Carthy E, Boyle D, ElNaggar H, Delanty N, Hamer H, Dogan M, Huchtemann T, K?rtvelyessy P, Rosenow F, Forster RJ, Henshall DC, Spain E. PMID: 28496112.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. J Physiol. 2017 02 01; 595(3):635-645. Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR. PMID: 27079855.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis. Arthritis Rheumatol. 2016 11; 68(11):2637-2645. Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS. PMID: 27159840.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open. 2016; 2(2):e000289. Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. PMID: 27651926.
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    22. Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes. Nat Commun. 2016 06 10; 7:11849. Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W. PMID: 27282753.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    23. Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight. 2016 May 19; 1(7). Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS. PMID: 27275015.
      View in: PubMed   Mentions: 10     Fields:    
    24. Receptor Protein Tyrosine Phosphatase a-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice. Arthritis Rheumatol. 2016 Feb; 68(2):359-69. Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N. PMID: 26414708.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention. Oncotarget. 2015 Dec 22; 6(41):43244-54. Buckley N, Boyle D, McArt D, Irwin G, Harkin DP, Lioe T, McQuaid S, James JA, Maxwell P, Hamilton P, Mullan PB, Salto-Tellez M. PMID: 26657114.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets. PLoS One. 2015; 10(8):e0136334. Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. PMID: 26288175.
      View in: PubMed   Mentions: 1     Fields:    
    27. DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul; 67(7):1978-80. Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS. PMID: 25808728.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    28. Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med. 2015 May 20; 7(288):288ra76. Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N. PMID: 25995222.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets. PLoS One. 2015; 10(4):e0124254. Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS. PMID: 25901943.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    30. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. PMID: 25545378.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. Ann Rheum Dis. 2015 Jun; 74(6):1311-6. Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS. PMID: 25398374.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCellsCTClinical Trials
    32. TGFß responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness. Ann Rheum Dis. 2016 Jan; 75(1):295-302. Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N. PMID: 25378349.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. PMID: 25041724.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. Arthritis Res Ther. 2014 Jun 12; 16(3):R121. Gong W, Kolker SJ, Usachev Y, Walder RY, Boyle DL, Firestein GS, Sluka KA. PMID: 24923411.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. J Inflamm (Lond). 2014; 11:14. Hammaker D, Boyle DL, Topolewski K, Firestein GS. PMID: 24855454.
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    36. Serum C-X-C motif chemokine 13 is elevated in early and established rheumatoid arthritis and correlates with rheumatoid factor levels. Arthritis Res Ther. 2014 Apr 25; 16(2):R103. Jones JD, Hamilton BJ, Challener GJ, de Brum-Fernandes AJ, Cossette P, Liang P, Masetto A, Ménard HA, Carrier N, Boyle DL, Rosengren S, Boire G, Rigby WF. PMID: 24766912.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    37. TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities. Oncotarget. 2014 Mar 30; 5(6):1609-20. D'Costa ZC, Higgins C, Ong CW, Irwin GW, Boyle D, McArt DG, McCloskey K, Buckley NE, Crawford NT, Thiagarajan L, Murray JT, Kennedy RD, Mulligan KA, Harkin DP, Waugh DJ, Scott CJ, Salto-Tellez M, Williams R, Mullan PB. PMID: 24742492.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain. Pain. 2014 Jun; 155(6):1150-60. Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS. PMID: 24631588.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    39. Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss. PLoS One. 2014; 9(1):e84818. Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS. PMID: 24400116.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Novel phosphoinositide 3-kinase d,? inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):271-80. Boyle DL, Kim HR, Topolewski K, Bartok B, Firestein GS. PMID: 24244039.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    41. Acid-sensing ion channel 3 deficiency increases inflammation but decreases pain behavior in murine arthritis. Arthritis Rheum. 2013 May; 65(5):1194-202. Sluka KA, Rasmussen LA, Edgar MM, O'Donnell JM, Walder RY, Kolker SJ, Boyle DL, Firestein GS. PMID: 23335302.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    42. Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum. 2013 May; 65(5):1171-80. Stanford SM, Maestre MF, Campbell AM, Bartok B, Kiosses WB, Boyle DL, Arnett HA, Mustelin T, Firestein GS, Bottini N. PMID: 23335101.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med. 2013; 5(4):40. Whitaker JW, Shoemaker R, Boyle DL, Hillman J, Anderson D, Wang W, Firestein GS. PMID: 23631487.
      View in: PubMed   Mentions: 44     Fields:    
    44. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol. 2013 Feb 01; 190(3):1297-303. Nakano K, Boyle DL, Firestein GS. PMID: 23277489.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    45. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. PMID: 22488549.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    46. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013 Jan; 72(1):110-7. Nakano K, Whitaker JW, Boyle DL, Wang W, Firestein GS. PMID: 22736089.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    47. PI3 kinase d is a key regulator of synoviocyte function in rheumatoid arthritis. Am J Pathol. 2012 May; 180(5):1906-16. Bartok B, Boyle DL, Liu Y, Ren P, Ball ST, Bugbee WD, Rommel C, Firestein GS. PMID: 22433439.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    48. Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice. Arthritis Rheum. 2012 Mar; 64(3):678-87. Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle DL, Burak EC, Sah RL, Firestein GS. PMID: 21953132.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    49. Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-terminal kinase pathway. Arthritis Res Ther. 2012 Feb 21; 14(1):R38. Lee SI, Boyle DL, Berdeja A, Firestein GS. PMID: 22353730.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis. 2012 Mar; 71(3):440-7. Rosengren S, Corr M, Firestein GS, Boyle DL. PMID: 22121136.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    51. CXCL13 as a marker for outcome of rheumatoid arthritis: comment on the article by Meeuwisse et al. Arthritis Rheum. 2011 Nov; 63(11):3646-7. Rosengren S, Kalunian KC, Kavanaugh A, Boyle DL. PMID: 21834069.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    52. Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45ß-deficient mice. Arthritis Rheum. 2011 Oct; 63(10):2949-55. Luo Y, Boyle DL, Hammaker D, Edgar M, Franzoso G, Firestein GS. PMID: 21702006.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid arthritis. Rheumatology (Oxford). 2012 Apr; 51(4):610-8. Hammaker D, Boyle DL, Firestein GS. PMID: 21613249.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    54. Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization, evolution of novel genes and seroprevalence in Australian livestock. J Gen Virol. 2011 Sep; 92(Pt 9):2160-2170. Gubala A, Davis S, Weir R, Melville L, Cowled C, Boyle D. PMID: 21593274.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    55. Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis. Ann Rheum Dis. 2011 May; 70(5):858-63. Corr M, Boyle DL, Ronacher LM, Lew BR, van Baarsen LG, Tak PP, Firestein GS. PMID: 21216819.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    56. CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis. Rheumatology (Oxford). 2011 Mar; 50(3):603-10. Rosengren S, Wei N, Kalunian KC, Kavanaugh A, Boyle DL. PMID: 21098574.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    57. Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression. PLoS One. 2010 Oct 15; 5(10):e13416. Toh ML, Gonzales G, Koenders MI, Tournadre A, Boyle D, Lubberts E, Zhou Y, Firestein GS, van den Berg WB, Miossec P. PMID: 20976214.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    58. Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res Ther. 2010; 12(2):R65. Rosengren S, Corr M, Boyle DL. PMID: 20380722.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    59. Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis. Int J Mol Med. 2010 Apr; 25(4):625-33. Auci DL, Mangano K, Destiche D, White SK, Huang Y, Boyle D, Frincke J, Reading CL, Nicoletti F. PMID: 20198312.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    60. Ngaingan virus, a macropod-associated rhabdovirus, contains a second glycoprotein gene and seven novel open reading frames. Virology. 2010 Mar 30; 399(1):98-108. Gubala A, Davis S, Weir R, Melville L, Cowled C, Walker P, Boyle D. PMID: 20089287.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    61. Inflammatory characteristics on ultrasound predict poorer longterm response to intraarticular corticosteroid injections in knee osteoarthritis. J Rheumatol. 2010 Mar; 37(3):650-5. Chao J, Wu C, Sun B, Hose MK, Quan A, Hughes TH, Boyle D, Kalunian KC. PMID: 20080918.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    62. Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis. 2010 May; 69(5):903-9. Kolker SJ, Walder RY, Usachev Y, Hillman J, Boyle DL, Firestein GS, Sluka KA. PMID: 19933746.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    63. Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling. Arthritis Rheum. 2009 Nov; 60(11):3229-40. Svensson CI, Inoue T, Hammaker D, Fukushima A, Papa S, Franzoso G, Schett G, Corr M, Boyle DL, Firestein GS. PMID: 19877043.
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    64. Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa. Int J Obes (Lond). 2009 Sep; 33(9):1031-8. Herbst KL, Coviello AD, Chang A, Boyle DL. PMID: 19621017.
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    65. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. PMID: 19564341.
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    66. Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression. J Immunol. 2009 Jul 15; 183(2):1360-7. Yoshizawa T, Hammaker D, Boyle DL, Corr M, Flavell R, Davis R, Schett G, Firestein GS. PMID: 19561096.
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    67. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity. 2009 Jun 19; 30(6):875-87. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. PMID: 19501000.
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    68. Kinetic analysis of synovial signalling and gene expression in animal models of arthritis. Ann Rheum Dis. 2010 May; 69(5):918-23. Fukushima A, Boyle DL, Corr M, Firestein GS. PMID: 19473996.
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    69. MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice. Neuroscience. 2009 Aug 18; 162(2):462-71. Sorkin LS, Boyle DL, Hammaker D, Herman DS, Vail E, Firestein GS. PMID: 19427893.
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    70. An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis. J Pharmacol Exp Ther. 2009 Jun; 329(3):1100-9. Offner H, Firestein GS, Boyle DL, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL. PMID: 19297421.
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    71. Genetic and epidemiological characterization of Stretch Lagoon orbivirus, a novel orbivirus isolated from Culex and Aedes mosquitoes in northern Australia. J Gen Virol. 2009 Jun; 90(Pt 6):1433-1439. Cowled C, Palacios G, Melville L, Weir R, Walsh S, Davis S, Gubala A, Lipkin WI, Briese T, Boyle D. PMID: 19282430.
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    72. Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum. 2008 Nov; 58(11):3439-49. Waldburger JM, Boyle DL, Pavlov VA, Tracey KJ, Firestein GS. PMID: 18975306.
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    73. Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study. Ann Rheum Dis. 2009 Jul; 68(7):1220-7. Buch MH, Boyle DL, Rosengren S, Saleem B, Reece RJ, Rhodes LA, Radjenovic A, English A, Tang H, Vratsanos G, O'Connor P, Firestein GS, Emery P. PMID: 18772191.
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    74. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. J Immunol. 2008 Sep 01; 181(5):3252-8. Yoshizawa T, Hammaker D, Sweeney SE, Boyle DL, Firestein GS. PMID: 18713996.
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    75. Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab. Arthritis Res Ther. 2008; 10(5):R105. Rosengren S, Wei N, Kalunian KC, Zvaifler NJ, Kavanaugh A, Boyle DL. PMID: 18761748.
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    76. Spinal p38 MAP kinase regulates peripheral cholinergic outflow. Arthritis Rheum. 2008 Sep; 58(9):2919-21. Waldburger JM, Boyle DL, Edgar M, Sorkin LS, Levine YA, Pavlov VA, Tracey K, Firestein GS. PMID: 18759350.
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    77. Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta. Ann Rheum Dis. 2009 Feb; 68(2):257-63. Corr M, Boyle DL, Ronacher L, Flores N, Firestein GS. PMID: 18653628.
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    78. The pathobiology of psoriatic synovium. Curr Opin Rheumatol. 2008 Jul; 20(4):404-7. Boyle DL, Kavanaugh A. PMID: 18525352.
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    79. Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev. 2008 Jun; 223:175-85. Silverman GJ, Boyle DL. PMID: 18613836.
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    80. Modulation of melanocortin signaling ameliorates uremic cachexia. Kidney Int. 2008 Jul; 74(2):180-6. Cheung WW, Rosengren S, Boyle DL, Mak RH. PMID: 18432186.
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    81. Genetic and epidemiological characterization of Middle Point orbivirus, a novel virus isolated from sentinel cattle in northern Australia. J Gen Virol. 2007 Dec; 88(Pt 12):3413-22. Cowled C, Melville L, Weir R, Walsh S, Hyatt A, Van Driel R, Davis S, Gubala A, Boyle D. PMID: 18024911.
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    82. Longterm culture of telomerase-transduced rheumatoid arthritis fibroblast-like synoviocytes display a distinct gene expression pattern. J Rheumatol. 2007 Oct; 34(10):1959-70. Sun Y, Firestein G, Boyle D, Gruber H, Cheung H. PMID: 17896808.
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    83. Vanadate, an inhibitor of stromelysin and collagenase expression, suppresses collagen induced arthritis. J Rheumatol. 2007 Sep; 34(9):1802-9. Oliver SJ, Firestein GS, Arsenault L, Cruz TF, Cheng TP, Banquerigo ML, Boyle DL, Brahn E. PMID: 17696279.
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    84. Assessment of rituximab's immunomodulatory synovial effects (ARISE trial). 1: clinical and synovial biomarker results. Ann Rheum Dis. 2008 Mar; 67(3):402-8. Kavanaugh A, Rosengren S, Lee SJ, Hammaker D, Firestein GS, Kalunian K, Wei N, Boyle DL. PMID: 17644541.
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    85. Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J Rheumatol. 2007 Mar; 34(3):620-2. Bresnihan B, Gerlag DM, Rooney T, Smeets TJ, Wijbrandts CA, Boyle D, Fitzgerald O, Kirkham BW, McInnes IB, Smith M, Ulfgren AK, Veale DJ, Tak PP. PMID: 17343309.
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    86. Cutting Edge: Bim is required for superantigen-mediated B cell death. J Immunol. 2007 Mar 01; 178(5):2636-40. Goodyear CS, Corr M, Sugiyama F, Boyle DL, Silverman GJ. PMID: 17312102.
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    87. Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol. 2007 Apr; 119(4):991-6. Rosengren S, Mueller JL, Anderson JP, Niehaus BL, Misaghi A, Anderson S, Boyle DL, Hoffman HM. PMID: 17320940.
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    88. Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2007; 9(3):R57. Hammaker DR, Boyle DL, Inoue T, Firestein GS. PMID: 17559674.
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    89. Acquisition, culture, and phenotyping of synovial fibroblasts. Methods Mol Med. 2007; 135:365-75. Rosengren S, Boyle DL, Firestein GS. PMID: 17951672.
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    90. Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment. Ann Rheum Dis. 2007 Apr; 66(4):545-7. Gerlag DM, Boyle DL, Rosengren S, Nash T, Tak PP, Firestein GS. PMID: 16984938.
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    91. Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med. 2006 Sep; 3(9):e338. Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, Albani S, Sorkin L, Firestein GS. PMID: 16953659.
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    92. Regulation of JNK by MKK-7 in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Jul; 54(7):2127-35. Inoue T, Hammaker D, Boyle DL, Firestein GS. PMID: 16802349.
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    93. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5484-9. Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. PMID: 16567640.
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    94. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May; 317(2):571-8. Cha HS, Boyle DL, Inoue T, Schoot R, Tak PP, Pine P, Firestein GS. PMID: 16452391.
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    95. PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum. 2006 Feb; 54(2):587-92. Cha HS, Rosengren S, Boyle DL, Firestein GS. PMID: 16447235.
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    96. A randomized, placebo-controlled phase I trial of DNA prime, recombinant fowlpox virus boost prophylactic vaccine for HIV-1. AIDS. 2006 Jan 09; 20(2):294-7. Kelleher AD, Puls RL, Bebbington M, Boyle D, Ffrench R, Kent SJ, Kippax S, Purcell DF, Thomson S, Wand H, Cooper DA, Emery S. PMID: 16511428.
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    97. PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53. Arthritis Res Ther. 2006; 8(6):R157. You X, Boyle DL, Hammaker D, Firestein GS. PMID: 17014719.
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    98. A randomized, blinded, parallel group, placebo controlled pilot study evaluating the effect of PVAC treatment in patients with diffuse systemic sclerosis. J Rheumatol. 2005 Dec; 32(12):2345-50. Genovese MC, Chakravarty EF, Boyle DL, Tutuncu Z, Thorburn CM, Halilhodzic M, Kroll S, Baughman J, Stewart S, Kavanaugh A. PMID: 16331761.
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    99. Fcgamma receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor alpha-blocking agents. Arthritis Rheum. 2005 Sep; 52(9):2693-6. Tutuncu Z, Kavanaugh A, Zvaifler N, Corr M, Deutsch R, Boyle D. PMID: 16142749.
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    100. Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum. 2005 Jun; 52(6):1876-84. Simelyte E, Rosengren S, Boyle DL, Corr M, Green DR, Firestein GS. PMID: 15934085.
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    101. Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes. J Immunol. 2005 May 15; 174(10):6424-30. Sweeney SE, Hammaker D, Boyle DL, Firestein GS. PMID: 15879144.
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    102. Phylogenetic analysis of the DNA polymerase gene of a novel alphaherpesvirus isolated from an Indian Gyps vulture. Virus Genes. 2005 May; 30(3):371-81. Cardoso M, Hyatt A, Selleck P, Lowther S, Prakash V, Pain D, Cunningham AA, Boyle D. PMID: 15830156.
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    103. Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. J Immunol. 2005 Apr 01; 174(7):4301-6. Inoue T, Hammaker D, Boyle DL, Firestein GS. PMID: 15778394.
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    104. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol. 2005 Jan 15; 174(2):864-70. Ohata J, Zvaifler NJ, Nishio M, Boyle DL, Kalled SL, Carson DA, Kipps TJ. PMID: 15634908.
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    105. Virus strains from a flock exhibiting unusually high mortality due to infectious bursal disease. Aust Vet J. 2004 Dec; 82(12):763-8. Ignjatovic J, Sapats S, Reece R, Gould A, Gould G, Selleck P, Lowther S, Boyle D, Westbury H. PMID: 15648939.
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    106. DNA mismatch repair enzyme expression in synovial tissue. Ann Rheum Dis. 2004 Dec; 63(12):1695-9. Simelyte E, Boyle DL, Firestein GS. PMID: 15547100.
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    107. Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis. J Rheumatol. 2004 Nov; 31(11):2106-14. Cheon H, Boyle DL, Firestein GS. PMID: 15517620.
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    108. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet. 2004 Nov 13-19; 364(9447):1779-85. Hoffman HM, Rosengren S, Boyle DL, Cho JY, Nayar J, Mueller JL, Anderson JP, Wanderer AA, Firestein GS. PMID: 15541451.
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    109. p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis. Arthritis Res Ther. 2005; 7(1):R12-8. Yamanishi Y, Boyle DL, Green DR, Keystone EC, Connor A, Zollman S, Firestein GS. PMID: 15642132.
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    110. Expression and regulation of cryopyrin and related proteins in rheumatoid arthritis synovium. Ann Rheum Dis. 2005 May; 64(5):708-14. Rosengren S, Hoffman HM, Bugbee W, Boyle DL. PMID: 15498798.
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    111. Structural, expression, and evolutionary analysis of mouse CIAS1. Gene. 2004 Aug 18; 338(1):25-34. Anderson JP, Mueller JL, Rosengren S, Boyle DL, Schaner P, Cannon SB, Goodyear CS, Hoffman HM. PMID: 15302403.
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    112. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol. 2004 Feb 01; 172(3):1612-8. Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS. PMID: 14734742.
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    113. Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers. Exp Neurol. 2003 Nov; 184(1):162-8. Sorkin LS, Moore J, Boyle DL, Yang L, Firestein GS. PMID: 14637089.
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    114. Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2003 Nov; 10(6):1002-10. Rosengren S, Firestein GS, Boyle DL. PMID: 14607859.
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    115. Quantitative biomarker analysis of synovial gene expression by real-time PCR. Arthritis Res Ther. 2003; 5(6):R352-60. Boyle DL, Rosengren S, Bugbee W, Kavanaugh A, Firestein GS. PMID: 14680510.
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    116. Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. Arthritis Rheum. 2003 Sep; 48(9):2450-60. Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS. PMID: 13130464.
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    117. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neurosci Lett. 2003 Apr 10; 340(2):119-22. Sorkin LS, Maruyama K, Boyle DL, Yang L, Marsala M, Firestein GS. PMID: 12668251.
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    118. Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid arthritis. J Immunol. 2003 Feb 15; 170(4):2214-20. Lee SH, Chang DK, Goel A, Boland CR, Bugbee W, Boyle DL, Firestein GS. PMID: 12574395.
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    119. Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3076-82. Boyle DL, Moore J, Yang L, Sorkin LS, Firestein GS. PMID: 12428252.
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    120. Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):10025-30. Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ, Firestein GS. PMID: 12119414.
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    121. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol. 2002 Feb 01; 168(3):1405-12. Yamanishi Y, Boyle DL, Clark M, Maki RA, Tortorella MD, Arner EC, Firestein GS. PMID: 11801682.
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    122. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol. 2002 Jan 01; 168(1):51-6. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvailfler NJ, Roord ST, Albani S, Carson DA, Raz E. PMID: 11751945.
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    123. Regulation of joint destruction and inflammation by p53 in collagen-induced arthritis. Am J Pathol. 2002 Jan; 160(1):123-30. Yamanishi Y, Boyle DL, Pinkoski MJ, Mahboubi A, Lin T, Han Z, Zvaifler NJ, Green DR, Firestein GS. PMID: 11786406.
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    124. Expression and regulation of inducible IkappaB kinase (IKK-i) in human fibroblast-like synoviocytes. Cell Immunol. 2001 Nov 25; 214(1):54-9. Aupperle KR, Yamanishi Y, Bennett BL, Mercurio F, Boyle DL, Firestein GS. PMID: 11902829.
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    125. Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. Arthritis Rheum. 2001 Aug; 44(8):1897-907. Tak PP, Gerlag DM, Aupperle KR, van de Geest DA, Overbeek M, Bennett BL, Boyle DL, Manning AM, Firestein GS. PMID: 11508443.
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    126. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. PMID: 11435459.
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    127. NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol. 2001 Feb 15; 166(4):2705-11. Aupperle K, Bennett B, Han Z, Boyle D, Manning A, Firestein G. PMID: 11160335.
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    128. Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis. J Pharmacol Exp Ther. 2001 Feb; 296(2):495-500. Boyle DL, Kowaluk EA, Jarvis MF, Lee CH, Bhagwat SS, Williams M, Firestein GS. PMID: 11160636.
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    129. Adenosine kinase inhibitor GP515 improves experimental colitis in mice. J Pharmacol Exp Ther. 2001 Jan; 296(1):99-105. Siegmund B, Rieder F, Albrich S, Wolf K, Bidlingmaier C, Firestein GS, Boyle D, Lehr HA, Loher F, Hartmann G, Endres S, Eigler A. PMID: 11123368.
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    130. The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol. 2000 Aug 01; 165(3):1652-8. Gerlag DM, Ransone L, Tak PP, Han Z, Palanki M, Barbosa MS, Boyle D, Manning AM, Firestein GS. PMID: 10903776.
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    131. Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor. J Leukoc Biol. 2000 Jul; 68(1):97-103. Eigler A, Matschke V, Hartmann G, Erhardt S, Boyle D, Firestein GS, Endres S. PMID: 10914495.
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    132. Regulation of CS1 fibronectin expression and function by IL-1 in endothelial cells. Cell Immunol. 2000 Feb 25; 200(1):1-7. Boyle DL, Shi Y, Gay S, Firestein GS. PMID: 10716877.
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    133. Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activity. Gene Ther. 1999 Dec; 6(12):1911-8. Boyle DL, Nguyen KH, Zhuang S, Shi Y, McCormack JE, Chada S, Firestein GS. PMID: 10637442.
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    134. Jun N-terminal kinase in rheumatoid arthritis. J Pharmacol Exp Ther. 1999 Oct; 291(1):124-30. Han Z, Boyle DL, Aupperle KR, Bennett B, Manning AM, Firestein GS. PMID: 10490895.
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    135. NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes. J Immunol. 1999 Jul 01; 163(1):427-33. Aupperle KR, Bennett BL, Boyle DL, Tak PP, Manning AM, Firestein GS. PMID: 10384145.
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    136. Dominant-negative p53 mutations in rheumatoid arthritis. Arthritis Rheum. 1999 Jun; 42(6):1088-92. Han Z, Boyle DL, Shi Y, Green DR, Firestein GS. PMID: 10366100.
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    137. p53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis. Arthritis Rheum. 1999 May; 42(5):948-53. Tak PP, Smeets TJ, Boyle DL, Kraan MC, Shi Y, Zhuang S, Zvaifler NJ, Breedveld FC, Firestein GS. PMID: 10323450.
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    138. Finger-like projections of plasma membrane in the most senescent fiber cells of human lenses. Curr Eye Res. 1998 Dec; 17(12):1118-23. Boyle DL, Takemoto LJ. PMID: 9872533.
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    139. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action. J Rheumatol. 1998 Sep; 25(9):1785-93. Brahn E, Banquerigo ML, Firestein GS, Boyle DL, Salzman AL, Szabó C. PMID: 9733461.
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    140. Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis. J Rheumatol. 1998 Jun; 25(6):1118-25. Nguyen KH, Boyle DL, McCormack JE, Chada S, Jolly DJ, Firestein GS. PMID: 9632074.
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    141. What proportion of common diagnostic tests appear redundant? Am J Med. 1998 Apr; 104(4):361-8. Bates DW, Boyle DL, Rittenberg E, Kuperman GJ, Ma'Luf N, Menkin V, Winkelman JW, Tanasijevic MJ. PMID: 9576410.
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    142. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol. 1998 Apr; 152(4):1091-8. Aupperle KR, Boyle DL, Hendrix M, Seftor EA, Zvaifler NJ, Barbosa M, Firestein GS. PMID: 9546370.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    143. AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity. 1998; 28(4):197-208. Han Z, Boyle DL, Manning AM, Firestein GS. PMID: 9892501.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    144. How promptly are inpatients treated for critical laboratory results? J Am Med Inform Assoc. 1998 Jan-Feb; 5(1):112-9. Kuperman GJ, Boyle D, Jha A, Rittenberg E, Ma'Luf N, Tanasijevic MJ, Teich JM, Winkelman J, Bates DW. PMID: 9452990.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    145. Posttranscriptional regulation of collagenase-1 gene expression in synoviocytes by adenosine receptor stimulation. Arthritis Rheum. 1997 Oct; 40(10):1772-9. Boyle DL, Han Z, Rutter JL, Brinckerhoff CE, Firestein GS. PMID: 9336410.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    146. Effect of tenidap on metalloproteinase gene expression in rheumatoid arthritis: a synovial biopsy study. J Clin Rheumatol. 1997 Aug; 3(4):194-202. Littman BH, Schumacher HR, Boyle DL, Weisman MH, Firestein GS. PMID: 19078187.
      View in: PubMed   Mentions: 1     Fields:    
    147. Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J Immunol. 1997 Jun 01; 158(11):5400-8. Bouma MG, Jeunhomme TM, Boyle DL, Dentener MA, Voitenok NN, van den Wildenberg FA, Buurman WA. PMID: 9164961.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    148. Confocal microscopy of cataracts from animal model systems: relevance to human nuclear cataract. Exp Eye Res. 1997 Apr; 64(4):565-72. Boyle DL, Blunt DS, Takemoto LJ. PMID: 9227275.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    149. Apoptosis in rheumatoid arthritis: p53 overexpression in rheumatoid arthritis synovium. Am J Pathol. 1996 Dec; 149(6):2143-51. Firestein GS, Nguyen K, Aupperle KR, Yeo M, Boyle DL, Zvaifler NJ. PMID: 8952546.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    150. Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells. Curr Eye Res. 1996 Aug; 15(8):869-75. Lindsey JD, Kashiwagi K, Boyle D, Kashiwagi F, Firestein GS, Weinreb RN. PMID: 8921230.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    151. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum. 1996 Jun; 39(6):923-30. Boyle DL, Sajjadi FG, Firestein GS. PMID: 8651985.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    152. EM immunolocalization of alpha-crystallins: association with the plasma membrane from normal and cataractous human lenses. Curr Eye Res. 1996 May; 15(5):577-82. Boyle DL, Takemoto L. PMID: 8670759.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    153. cDNA cloning and characterization of A3i, an alternatively spliced rat A3 adenosine receptor variant. FEBS Lett. 1996 Mar 11; 382(1-2):125-9. Sajjadi FG, Boyle DL, Domingo RC, Firestein GS. PMID: 8612733.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    154. Quantitative analysis of interleukin-1-alpha gene expression in middle ear cholesteatoma. Laryngoscope. 1996 Feb; 106(2 Pt 1):217-20. Bujía J, Kim C, Boyle D, Hammer C, Firestein G, Kastenbauer E. PMID: 8583857.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    155. Characterization of rod outer segment plasma membrane proteins which bind to the mannose receptor. Curr Eye Res. 1995 Jun; 14(6):465-71. Yan F, Lutz DA, Shepherd VL, Boyle D, McLaughlin BJ. PMID: 7671628.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    156. Relationship between medication errors and adverse drug events. J Gen Intern Med. 1995 Apr; 10(4):199-205. Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape L. PMID: 7790981.
      View in: PubMed   Mentions: 195     Fields:    Translation:Humans
    157. Potential identifiability and preventability of adverse events using information systems. J Am Med Inform Assoc. 1994 Sep-Oct; 1(5):404-11. Bates DW, O'Neil AC, Boyle D, Teich J, Chertow GM, Komaroff AL, Brennan TA. PMID: 7850564.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    158. Immunolocalization of the C-terminal and N-terminal regions of alpha-A and alpha-B crystallins. Curr Eye Res. 1994 Jul; 13(7):497-504. Boyle D, Takemoto L. PMID: 7924414.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    159. Protective effect of an adenosine kinase inhibitor in septic shock. J Immunol. 1994 Jun 15; 152(12):5853-9. Firestein GS, Boyle D, Bullough DA, Gruber HE, Sajjadi FG, Montag A, Sambol B, Mullane KM. PMID: 8207212.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    160. Early synovitis--synoviocytes and mononuclear cells. Semin Arthritis Rheum. 1994 Jun; 23(6 Suppl 2):11-6. Zvaifler NJ, Boyle D, Firestein GS. PMID: 7939726.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    161. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 1994 May; 37(5):644-52. Firestein GS, Boyle DL, Yu C, Paine MM, Whisenand TD, Zvaifler NJ, Arend WP. PMID: 8185691.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    162. Mechanisms of methotrexate action in rheumatoid arthritis. Selective decrease in synovial collagenase gene expression. Arthritis Rheum. 1994 Feb; 37(2):193-200. Firestein GS, Paine MM, Boyle DL. PMID: 8129774.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    163. Molecular chaperone properties of the high molecular weight aggregate from aged lens. Curr Eye Res. 1994 Jan; 13(1):35-44. Takemoto L, Boyle D. PMID: 8156824.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    164. The effect of swainsonine on the phagocytosis of rod outer segments by rat RPE. Curr Eye Res. 1990 May; 9(5):407-14. Boyle DL, McLaughlin BJ. PMID: 2116954.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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