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    Varykina Thackray

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0674
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Middlebury College, Middlebury, VTB.A.1991Biology
      University of Colorado Health Sciences Center, Denver, COPh.D.2002Molecular Biology
      UC San Diego, San Diego, CA2008Reproductive Endocrinology
      Collapse Awards and Honors
      2009Women in Endocrinology Young Investigator Award
      2012Endocrine Society Early Investigators Award
      2017Association for Women in Science San Diego Achievement in Outreach or Community Service Award

      Collapse Overview 
      Collapse Overview
      Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, with a prevalence of 10-15%. In addition to a reproductive phenotype that results in an increased risk of infertility, miscarriage and pregnancy complications, a majority of women with PCOS have metabolic abnormalities that result in an increased risk of type 2 diabetes, gestational diabetes and cardiovascular disease. The main objective of our research is to understand the etiology and pathophysiology of PCOS using relevant mouse and tissue culture models.

      Collapse Research 
      Collapse Research Activities and Funding
      Project I - Role of FSH in Female Infertility
      NIH/NICHD P50HD012303Aug 1, 2016 - Mar 31, 2021
      Role: Co-Investigator
      Transcriptional control of pituitary gonadotropin genes
      NIH/NICHD R01HD067448Aug 23, 2011 - May 31, 2016
      Role: Principal Investigator
      Project I - Integration of Hormone Signaling in the Pituitary Gonadotrope
      NIH/NICHD P50 HD012303Apr 1, 2009 - Mar 31, 2014
      Role: Co-Investigator
      Integration of PR and FoxO Signaling in Pituitary Gonadotropes
      NIH/NIDDK K01DK080467Sep 1, 2008 - Aug 31, 2011
      Role: Principal Investigator
      The Role of Smads and AR in FSHbeta Gene Expression
      NIH/NIDDK F32DK065437Sep 1, 2003 - Aug 31, 2006
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray V. Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. Endocrinology. 2017 Sep 01; 158(9):2988-3003. PMID: 28911175.
        View in: PubMed
      2. Kelley ST, Skarra DV, Rivera AJ, Thackray V. The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One. 2016; 11(1):e0146509. PMID: 26731268; PMCID: PMC4701222.
      3. Kauffman AS, Thackray V, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
      4. Skarra DV, Thackray V. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015 Apr 15; 405:14-24. PMID: 25676570; PMCID: PMC4363278.
      5. Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray V. Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS One. 2014; 9(11):e113839. PMID: 25423188; PMCID: PMC4244159.
      6. Thackray V. Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):62-70. PMID: 24099863; PMCID: PMC3947687.
      7. Skarra DV, Arriola DJ, Benson CA, Thackray V. Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes. Mol Endocrinol. 2013 Nov; 27(11):1825-39. PMID: 24065703; PMCID: PMC3805845.
      8. Benson CA, Kurz TL, Thackray V. A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription. Endocrinology. 2013 Sep; 154(9):3016-21. PMID: 23766128; PMCID: PMC3749480.
      9. Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray V. FOXO1 transcription factor inhibits luteinizing hormone ß gene expression in pituitary gonadotrope cells. J Biol Chem. 2012 Sep 28; 287(40):33424-35. PMID: 22865884; PMCID: PMC3460444.
      10. Breen KM, Thackray V, Hsu T, Mak-McCully RA, Coss D, Mellon PL. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703; PMCID: PMC3458227.
      11. Ghochani Y, Saini JK, Mellon PL, Thackray V. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749; PMCID: PMC3320250.
      12. Coss D, Mellon PL, Thackray V. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900; PMCID: PMC2933269.
      13. Breen KM, Thackray V, Coss D, Mellon PL. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224; PMCID: PMC2875819.
      14. Thackray V, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958; PMCID: PMC2815122.
      15. Thackray V, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225; PMCID: PMC2671912.
      16. Sasson R, Luu SH, Thackray V, Mellon PL. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486; PMCID: PMC2453092.
      17. Thackray V, Mellon PL. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204; PMCID: PMC2275352.
      18. McGillivray SM, Thackray V, Coss D, Mellon PL. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263; PMCID: PMC2932480.
      19. Thackray V, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544; PMCID: PMC2941439.
      20. Coss D, Thackray V, Deng CX, Mellon PL. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509; PMCID: PMC2932483.
      21. Spady TJ, Shayya R, Thackray V, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939; PMCID: PMC2932479.
      22. Thackray V, Toft DO, Nordeen SK. Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates. Mol Endocrinol. 2003 Dec; 17(12):2543-53. PMID: 14551264.
        View in: PubMed