Varykina Thackray

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
DepartmentReproductive Medicine
Address9500 Gilman Drive #0674
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Middlebury College, Middlebury, VTB.A.1991Biology
    University of Colorado Health Sciences Center, Denver, COPh.D.2002Molecular Biology
    UC San Diego, San Diego, CA2008Reproductive Endocrinology
    Collapse Awards and Honors
    2009Women in Endocrinology Young Investigator Award
    2012Endocrine Society Early Investigators Award
    2017Association for Women in Science San Diego Achievement in Outreach or Community Service Award

    Collapse Overview 
    Collapse Overview
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, with a prevalence of 10-15%. In addition to a reproductive phenotype that results in an increased risk of infertility, miscarriage and pregnancy complications, a majority of women with PCOS have metabolic abnormalities that result in an increased risk of type 2 diabetes, gestational diabetes and cardiovascular disease. The main objective of our research is to understand the etiology and pathophysiology of PCOS using relevant mouse and tissue culture models.

    Collapse Research 
    Collapse Research Activities and Funding
    Project I - Role of FSH in Female Infertility
    NIH/NICHD P50HD012303Aug 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Transcriptional control of pituitary gonadotropin genes
    NIH/NICHD R01HD067448Aug 23, 2011 - May 31, 2016
    Role: Principal Investigator
    Project I - Integration of Hormone Signaling in the Pituitary Gonadotrope
    NIH/NICHD P50 HD012303Apr 1, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    NIH/NIDDK K01DK080467Sep 1, 2008 - Aug 31, 2011
    Role: Principal Investigator
    The Role of Smads and AR in FSHbeta Gene Expression
    NIH/NIDDK F32DK065437Sep 1, 2003 - Aug 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May-Jun; 3(3). PMID: 29795809.
      View in: PubMed
    2. Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG. Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism. J Clin Endocrinol Metab. 2018 Jan 23. PMID: 29370410.
      View in: PubMed
    3. Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray VG. Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. Endocrinology. 2017 09 01; 158(9):2988-3003. PMID: 28911175.
      View in: PubMed
    4. Kelley ST, Skarra DV, Rivera AJ, Thackray VG. The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One. 2016; 11(1):e0146509. PMID: 26731268; PMCID: PMC4701222.
    5. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    6. Skarra DV, Thackray VG. FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol. 2015 Apr 15; 405:14-24. PMID: 25676570; PMCID: PMC4363278.
    7. Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray VG. Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes. PLoS One. 2014; 9(11):e113839. PMID: 25423188; PMCID: PMC4244159.
    8. Thackray VG. Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors. Mol Cell Endocrinol. 2014 Mar 25; 385(1-2):62-70. PMID: 24099863; PMCID: PMC3947687.
    9. Skarra DV, Arriola DJ, Benson CA, Thackray VG. Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes. Mol Endocrinol. 2013 Nov; 27(11):1825-39. PMID: 24065703; PMCID: PMC3805845.
    10. Benson CA, Kurz TL, Thackray VG. A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription. Endocrinology. 2013 Sep; 154(9):3016-21. PMID: 23766128; PMCID: PMC3749480.
    11. Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray VG. FOXO1 transcription factor inhibits luteinizing hormone ß gene expression in pituitary gonadotrope cells. J Biol Chem. 2012 Sep 28; 287(40):33424-35. PMID: 22865884; PMCID: PMC3460444.
    12. Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL. Stress levels of glucocorticoids inhibit LHß-subunit gene expression in gonadotrope cells. Mol Endocrinol. 2012 Oct; 26(10):1716-31. PMID: 22851703; PMCID: PMC3458227.
    13. Ghochani Y, Saini JK, Mellon PL, Thackray VG. FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone ß-subunit promoter. Endocrinology. 2012 Apr; 153(4):2023-33. PMID: 22294749; PMCID: PMC3320250.
    14. Coss D, Mellon PL, Thackray VG. A FoxL in the Smad house: activin regulation of FSH. Trends Endocrinol Metab. 2010 Sep; 21(9):562-8. PMID: 20598900; PMCID: PMC2933269.
    15. Breen KM, Thackray VG, Coss D, Mellon PL. Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene. Endocrinology. 2010 Jun; 151(6):2669-80. PMID: 20357224; PMCID: PMC2875819.
    16. Thackray VG, Mellon PL, Coss D. Hormones in synergy: regulation of the pituitary gonadotropin genes. Mol Cell Endocrinol. 2010 Jan 27; 314(2):192-203. PMID: 19747958; PMCID: PMC2815122.
    17. Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL. Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression. Endocrinology. 2009 May; 150(5):2395-403. PMID: 19106225; PMCID: PMC2671912.
    18. Sasson R, Luu SH, Thackray VG, Mellon PL. Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope. Endocrinology. 2008 Jul; 149(7):3643-55. PMID: 18403486; PMCID: PMC2453092.
    19. Thackray VG, Mellon PL. Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteins. Endocrinology. 2008 Mar; 149(3):1091-102. PMID: 18079204; PMCID: PMC2275352.
    20. McGillivray SM, Thackray VG, Coss D, Mellon PL. Activin and glucocorticoids synergistically activate follicle-stimulating hormone beta-subunit gene expression in the immortalized LbetaT2 gonadotrope cell line. Endocrinology. 2007 Feb; 148(2):762-73. PMID: 17082263; PMCID: PMC2932480.
    21. Thackray VG, McGillivray SM, Mellon PL. Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotrope. Mol Endocrinol. 2006 Sep; 20(9):2062-79. PMID: 16675544; PMCID: PMC2941439.
    22. Coss D, Thackray VG, Deng CX, Mellon PL. Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol. 2005 Oct; 19(10):2610-23. PMID: 15961509; PMCID: PMC2932483.
    23. Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL. Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes. Mol Endocrinol. 2004 Apr; 18(4):925-40. PMID: 14701939; PMCID: PMC2932479.
    24. Thackray VG, Toft DO, Nordeen SK. Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates. Mol Endocrinol. 2003 Dec; 17(12):2543-53. PMID: 14551264.
      View in: PubMed
    25. Thackray VG, Nordeen SK. High-yield purification of functional, full-length steroid receptor coactivator 1 expressed in insect cells. Biotechniques. 2002 Feb; 32(2):260, 262-3. PMID: 11848398.
      View in: PubMed
    26. Wan Y, Coxe KK, Thackray VG, Housley PR, Nordeen SK. Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor. Mol Endocrinol. 2001 Jan; 15(1):17-31. PMID: 11145736.
      View in: PubMed
    27. Thackray VG, Young RH, Hooper JE, Nordeen SK. Estrogen agonist and antagonist action on the human estrogen receptor in Drosophila. Endocrinology. 2000 Oct; 141(10):3912-5. PMID: 11014249.
      View in: PubMed
    28. Kelley ST, Thackray VG. Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms. J Mol Evol. 1999 Nov; 49(5):609-14. PMID: 10552042.
      View in: PubMed
    29. Thackray VG, Lieberman BA, Nordeen SK. Differential gene induction by glucocorticoid and progesterone receptors. J Steroid Biochem Mol Biol. 1998 Aug; 66(4):171-8. PMID: 9744514.
      View in: PubMed