Victor Nizet

Title(s)Distinguished Professor, Pediatrics
SchoolHealth Sciences
Address9500 Gilman Drive #0760
La Jolla CA 92093
Phone858-534-7408
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    Other Positions
    Title(s)Distinguished Professor, School of Pharmacy and Pharmaceutical Science


    Collapse Biography 
    Collapse Education and Training
    Reed College, Portland, ORBA05/1984Biology
    Stanford University, Stanford, CAMD05/1989Medicine
    Collapse Awards and Honors
    2019NIH/NIAID Merit Award (R37)
    2019ISI Highly Cited Researcher (Cross-Field)
    2018Inaugural UCSD Health Sciences Award for Excellence in Junior Faculty Mentoring
    2017UCSD Chancellor's Associates Award for Excellence in Research in Science & Engineering
    2013UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring
    2013Rady Children’s Hospital Award for Excellence in Research
    2012Elected to Fellowship in the American Academy of Microbiology
    2010Elected to Membership in the Association of American Physicians
    2008E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
    2008Stephen Silberstein Senior Fellow of the American Asthma Foundation
    2006Elected to Membership in the American Society for Clinical Investigation
    2006Elected to the American Pediatric Society
    2004Career Investigator Award, American Lung Association
    2004Established Investigator Award, American Heart Association
    2002Named the 39th Mallinckrodt Scholar by the Edward Mallinckrodt, Jr. Foundation
    2002Pediatric Infectious Diseases Society Young Investigator Award
    2002Elected to the Society for Pediatric Research
    2001UCSD Department of Pediatrics Commitment to Resident Education Award
    2000UCSD Department of Pediatrics Outstanding Faculty Teacher of the Year
    1993Sidney Farber Outstanding Houseofficer Award, Children’s Hospital, Boston
    1984Class of 1922 Award, Reed College, “Most Outstanding Senior Thesis”
    1984Phi Beta Kappa, Reed College

    Collapse Overview 
    Collapse Overview
    Victor Nizet is a Distinguished Professor and Vice Chair for Basic Research and Chief of the Division of Host-Microbe Systems & Therapeutics at the University of California, San Diego (UCSD), School of Medicine and Distinguished Professor at UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences. Dr. Nizet is a graduate of Reed College, received his medical training at Stanford University School of Medicine, completed a Residency and Chief Residency in Pediatrics at Harvard University's Children's Hospital in Boston, Massachusetts, and a then a Fellowship in Pediatric Infectious Diseases at the University of Washington’s Children's Hospital in Seattle. Dr. Nizet is Faculty Lead for the UCSD Collaborative to Halt Antibiotic-Resistant Microbes (CHARM), a multidisciplinary research and educational program that debuted in Fall 2019. Dr. Nizet has authored over 440 peer-reviewed publications and has collaborated with several biotechnology interests in developing new antibiotic and immune-based therapies against drug-resistant pathogens. Details of his research program can be found on the laboratory website: http://nizetlab.ucsd.edu
    Collapse Interests

    Collapse Research 
    Collapse Research Activities and Funding
    Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
    NIH P50HD106463Sep 10, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune Sensitization
    NIH R01AI145310Aug 1, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung InnateDefenses in the Fetus and Newborn Infant
    NIH R01AI142864Jul 17, 2019 - Jun 30, 2022
    Role: Co-Principal Investigator
    C3-Dependent Intracellular Killing in Innate Immunity and Bacterial Pathogenesis
    NIH R01AI145325Mar 5, 2019 - Feb 29, 2024
    Role: Co-Principal Investigator
    2018 Streptococcal Biology Gordon Research Conference
    NIH R13AI140636Jul 1, 2018 - Jun 30, 2019
    Role: Principal Investigator
    Broad recognition of group A Streptococcus M proteins
    NIH R21AI140436May 18, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH P50HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Academic Training in Therapeutic Advancement for Child Health (ATTACH)
    NIH T32HD087978May 1, 2016 - Apr 30, 2026
    Role: Co-Principal Investigator
    Glycoprotein Remodeling in the Vasculopathy and Coagulopathy of Sepsis
    NIH R01HL125352Sep 15, 2014 - May 31, 2020
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH R01AI110713Feb 1, 2014 - Jan 31, 2020
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R56AI096837Jul 1, 2011 - Jul 31, 2019
    Role: Co-Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R01AI096837Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    NIH R01AI093451Apr 5, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
    NIH R56AI090863Aug 2, 2010 - Jul 31, 2011
    Role: Principal Investigator
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    NIH R01AI077780Sep 1, 2008 - Jan 31, 2020
    Role: Principal Investigator
    Sialic Acid O-Acetylation in GBS Pathogenesis &Immunity
    NIH R01HD051796Apr 7, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Molecular Analyses and Interventions for Biodefense and Emerging Pathogens
    NIH U54AI057153Sep 4, 2003 - Feb 28, 2014
    Role: Co-Investigator
    Cathelicidin in Skin Immunity
    NIH R37AI052453Sep 15, 2002 - Feb 29, 2024
    Role: Co-Principal Investigator
    Cathelicidin in Skin Immunity
    NIH R01AI052453Sep 15, 2002 - Mar 31, 2018
    Role: Principal Investigator
    SLS: Molecular Basis and Role in Invasive GAS Disease
    NIH R01AI048694Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    PENETRATION OF THE BLOOD BRAIN BARRIER IN GBS MENINGITIS
    NIH R03HD037224Feb 1, 1999 - Aug 31, 2001
    Role: Principal Investigator
    MOLECULAR BASIS OF LUNG INJURY IN GBS PNEUMONIA
    NIH K08AI001451Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Combating Antibiotic Resistance Into the Next Generation (CARING)
    NIH T32AI007036Jul 1, 1976 - Jun 30, 2026
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Uremic serum damages endothelium by provoking excessive neutrophil extracellular trap formation. Sci Rep. 2021 Nov 02; 11(1):21439. Lee HW, Nizet V, An JN, Lee HS, Song YR, Kim SG, Kim JK. PMID: 34728714; PMCID: PMC8563801.
      View in: PubMed   Mentions:
    2. Editorial: Host-Pathogen Interactions During Pneumococcal Infection. Front Cell Infect Microbiol. 2021; 11:752959. Yamaguchi M, Kinjo Y, Nizet V. PMID: 34760720; PMCID: PMC8573109.
      View in: PubMed   Mentions:
    3. The S Protein of Group B Streptococcus Is a Critical Virulence Determinant That Impacts the Cell Surface Virulome. Front Microbiol. 2021; 12:729308. Campeau A, Uchiyama S, Sanchez C, Sauceda C, Nizet V, Gonzalez DJ. PMID: 34721327; PMCID: PMC8551713.
      View in: PubMed   Mentions:
    4. Bacterial Membrane-Derived Vesicles Attenuate Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus. Microorganisms. 2021 Sep 29; 9(10). Kumaraswamy M, Wiull K, Joshi B, Sakoulas G, Kousha A, Vaaje-Kolstad G, Johannessen M, Hegstad K, Nizet V, Askarian F. PMID: 34683376; PMCID: PMC8539228.
      View in: PubMed   Mentions:
    5. Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis. mBio. 2021 Sep 21; e0118121. Golden GJ, Toledo AG, Marki A, Sorrentino JT, Morris C, Riley RJ, Spliid C, Chen Q, Cornax I, Lewis NE, Varki N, Le D, Malmström J, Karlsson C, Ley K, Nizet V, Esko JD. PMID: 34544271.
      View in: PubMed   Mentions:    Fields:    
    6. Immunobiology of the Classical Lancefield Group A Streptococcal Carbohydrate Antigen. Infect Immun. 2021 Sep 20; IAI0029221. Gao NJ, Rodas Lima E, Nizet V. PMID: 34543125.
      View in: PubMed   Mentions:    Fields:    
    7. Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption. Sci Signal. 2021 Aug 31; 14(698):eabc1044. Rada CC, Mejia-Pena H, Grimsey NJ, Canto Cordova I, Olson J, Wozniak JM, Gonzalez DJ, Nizet V, Trejo J. PMID: 34516752.
      View in: PubMed   Mentions:    Fields:    
    8. Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunol Cell Biol. 2021 Aug 30. Richter J, Monteleone MM, Cork AJ, Barnett TC, Nizet V, Brouwer S, Schroder K, Walker MJ. PMID: 34462965.
      View in: PubMed   Mentions:    Fields:    
    9. Machine Learning of Bacterial Transcriptomes Reveals Responses Underlying Differential Antibiotic Susceptibility. mSphere. 2021 Aug 25; 6(4):e0044321. Sastry AV, Dillon N, Anand A, Poudel S, Hefner Y, Xu S, Szubin R, Feist AM, Nizet V, Palsson B. PMID: 34431696.
      View in: PubMed   Mentions:    Fields:    
    10. Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus. Commun Biol. 2021 06 25; 4(1):793. Machado H, Seif Y, Sakoulas G, Olson CA, Hefner Y, Anand A, Jones YZ, Szubin R, Palsson BO, Nizet V, Feist AM. PMID: 34172889.
      View in: PubMed   Mentions: 1  Translation:HumansCells
    11. Hypoxia-Inducible Factor 1 Alpha Is Dispensable for Host Defense of Group B Streptococcus Colonization and Infection. J Innate Immun. 2021 May 21; 1-13. Lum GR, Mercado V, van Ens D, Nizet V, Kimmey JM, Patras KA. PMID: 34023827.
      View in: PubMed   Mentions:    Fields:    
    12. Current Paradigms of Combination therapy in Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia: Does it Work, Which Combination and For Which Patients? Clin Infect Dis. 2021 May 16. Rose W, Fantl M, Geriak M, Nizet V, Sakoulas G. PMID: 33993226.
      View in: PubMed   Mentions: 2     Fields:    
    13. Ticagrelor Increases Platelet-Mediated Staphylococcus aureus Killing Resulting in Clearance of Bacteremia. J Infect Dis. 2021 May 09. Ulloa E, Uchiyama S, Gillespie R, Nizet V, Sakoulas G. PMID: 33966075.
      View in: PubMed   Mentions:    Fields:    
    14. Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy. J Infect Dis. 2021 Apr 08; 223(7):1260-1264. Wilde S, Olivares KL, Nizet V, Hoffman HM, Radhakrishna S, LaRock CN. PMID: 32808035.
      View in: PubMed   Mentions: 2     Fields:    
    15. Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface. Cell Rep. 2021 03 30; 34(13):108924. Hirose Y, Yamaguchi M, Sumitomo T, Nakata M, Hanada T, Okuzaki D, Motooka D, Mori Y, Kawasaki H, Coady A, Uchiyama S, Hiraoka M, Zurich RH, Amagai M, Nizet V, Kawabata S. PMID: 33789094.
      View in: PubMed   Mentions:    Fields:    
    16. Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia. Sci Transl Med. 2021 03 24; 13(586). Sun J, Uchiyama S, Olson J, Morodomi Y, Cornax I, Ando N, Kohno Y, Kyaw MMT, Aguilar B, Haste NM, Kanaji S, Kanaji T, Rose WE, Sakoulas G, Marth JD, Nizet V. PMID: 33762439.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Driving to Safety: CRISPR-Based Genetic Approaches to Reducing Antibiotic Resistance. Trends Genet. 2021 08; 37(8):745-757. Bier E, Nizet V. PMID: 33745750.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. J Exp Med. 2021 03 01; 218(3). Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K. PMID: 33275138.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    19. The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection. Nat Commun. 2021 02 23; 12(1):1230. Askarian F, Uchiyama S, Masson H, Sørensen HV, Golten O, Bunæs AC, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Arntzen MØ, Schmidt B, Zurich RH, van Sorge NM, Eijsink VGH, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G. PMID: 33623002.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. More than a Pore: Nonlytic Antimicrobial Functions of Complement and Bacterial Strategies for Evasion. Microbiol Mol Biol Rev. 2021 02 17; 85(1). Bjanes E, Nizet V. PMID: 33504655.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae. mBio. 2021 01 19; 12(1). Saha S, Coady A, Sasmal A, Kawanishi K, Choudhury B, Yu H, Sorensen RU, Inostroza J, Schoenhofen IC, Chen X, Münster-Kühnel A, Sato C, Kitajima K, Ram S, Nizet V, Varki A. PMID: 33468699.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Novel Models of Streptococcus canis Colonization and Disease Reveal Modest Contributions of M-Like (SCM) Protein. Microorganisms. 2021 Jan 16; 9(1). Cornax I, Zulk J, Olson J, Fulde M, Nizet V, Patras KA. PMID: 33467030.
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    23. A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical Pseudomonas aeruginosa Isolates. mSphere. 2021 01 13; 6(1). Menon ND, Kumar MS, Satheesh Babu TG, Bose S, Vijayakumar G, Baswe M, Chatterjee M, D'Silva JR, Shetty K, Haripriyan J, Kumar A, Nair S, Somanath P, Nair BG, Nizet V, Kumar GB. PMID: 33441405.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    24. Identifying the effect of vancomycin on health care-associated methicillin-resistant Staphylococcus aureus strains using bacteriological and physiological media. Gigascience. 2021 01 09; 10(1). Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Seif Y, Lamsa A, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Pogliano J, Nizet V, Feist AM, Palsson BO. PMID: 33420779.
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    25. Erratum for Rivera-Hernandez et al., "An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model". mBio. 2020 Dec 01; 11(6). Rivera-Hernandez T, Carnathan DG, Jones S, Cork AJ, Davies MR, Moyle PM, Toth I, Batzloff MR, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. PMID: 33262263.
      View in: PubMed   Mentions:    Fields:    
    26. Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq. Cell Host Microbe. 2021 01 13; 29(1):107-120.e6. Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard JC, Nizet V, Veening JW. PMID: 33120116.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Evaluation of IL-17D in Host Immunity to Group A Streptococcus Infection. J Immunol. 2020 12 01; 205(11):3122-3129. Washington A, Varki N, Valderrama JA, Nizet V, Bui JD. PMID: 33077643.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):26895-26906. Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P. PMID: 33055214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Evaluating Organism-Wide Changes in the Metabolome and Microbiome following a Single Dose of Antibiotic. mSystems. 2020 Oct 06; 5(5). Vrbanac A, Patras KA, Jarmusch AK, Mills RH, Shing SR, Quinn RA, Vargas F, Gonzalez DJ, Dorrestein PC, Knight R, Nizet V. PMID: 33024048.
      View in: PubMed   Mentions: 1  
    30. Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes. Nat Commun. 2020 10 06; 11(1):5018. Brouwer S, Barnett TC, Ly D, Kasper KJ, De Oliveira DMP, Rivera-Hernandez T, Cork AJ, McIntyre L, Jespersen MG, Richter J, Schulz BL, Dougan G, Nizet V, Yuen KY, You Y, McCormick JK, Sanderson-Smith ML, Davies MR, Walker MJ. PMID: 33024089.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. EBioMedicine. 2020 Oct; 60:102984. Sun J, LaRock DL, Skowronski EA, Kimmey JM, Olson J, Jiang Z, O'Donoghue AJ, Nizet V, LaRock CN. PMID: 32979835.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia. Clin Infect Dis. 2020 09 12; 71(6):1413-1418. Ulloa ER, Singh KV, Geriak M, Haddad F, Murray BE, Nizet V, Sakoulas G. PMID: 31773134.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures. Cell. 2020 09 03; 182(5):1311-1327.e14. Wozniak JM, Mills RH, Olson J, Caldera JR, Sepich-Poore GD, Carrillo-Terrazas M, Tsai CM, Vargas F, Knight R, Dorrestein PC, Liu GY, Nizet V, Sakoulas G, Rose W, Gonzalez DJ. PMID: 32888495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Multidimensional Proteome Profiling of Blood-Brain Barrier Perturbation by Group B Streptococcus. mSystems. 2020 Aug 25; 5(4). Campeau A, Mills RH, Blanchette M, Bajc K, Malfavon M, Munji RN, Deng L, Hancock B, Patras KA, Olson J, Nizet V, Daneman R, Doran K, Gonzalez DJ. PMID: 32843537.
      View in: PubMed   Mentions:
    35. An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses. ACS Chem Biol. 2020 08 21; 15(8):2060-2069. Woehl JL, Kitamura S, Dillon N, Han Z, Edgar LJ, Nizet V, Wolan DW. PMID: 32662975.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    36. T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 Streptococcus pyogenes. mBio. 2020 07 21; 11(4). Chen YH, Li SH, Yang YC, Hsu SH, Nizet V, Chang YC. PMID: 32694142.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    37. Antibiotics and Innate Immunity: A Cooperative Effort Toward the Successful Treatment of Infections. Open Forum Infect Dis. 2020 Aug; 7(8):ofaa302. Berti A, Rose W, Nizet V, Sakoulas G. PMID: 32818143.
      View in: PubMed   Mentions: 4  
    38. Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response. Proc Natl Acad Sci U S A. 2020 07 21; 117(29):17228-17239. Poudel S, Tsunemoto H, Seif Y, Sastry AV, Szubin R, Xu S, Machado H, Olson CA, Anand A, Pogliano J, Nizet V, Palsson BO. PMID: 32616573.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    39. Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry. J Am Chem Soc. 2020 06 24; 142(25):10899-10904. Kitamura S, Zheng Q, Woehl JL, Solania A, Chen E, Dillon N, Hull MV, Kotaniguchi M, Cappiello JR, Kitamura S, Nizet V, Sharpless KB, Wolan DW. PMID: 32479075.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Interleukin (IL)-1β and IL-10 Host Responses in Patients With Staphylococcus aureus Bacteremia Determined by Antimicrobial Therapy. Clin Infect Dis. 2020 06 10; 70(12):2634-2640. Volk CF, Burgdorf S, Edwardson G, Nizet V, Sakoulas G, Rose WE. PMID: 31365924.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis. Chembiochem. 2020 09 14; 21(18):2595-2598. Li Y, Fin A, Rovira AR, Su Y, Dippel AB, Valderrama JA, Riestra AM, Nizet V, Hammond MC, Tor Y. PMID: 32346955.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    42. Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection. iScience. 2020 Jun 26; 23(6):101207. Lund SJ, Patras KA, Kimmey JM, Yamamura A, Butcher LD, Del Rosario PGB, Hernandez GE, McCoy AM, Lakhdari O, Nizet V, Prince LS. PMID: 32535023.
      View in: PubMed   Mentions:
    43. All major cholesterol-dependent cytolysins use glycans as cellular receptors. Sci Adv. 2020 May; 6(21):eaaz4926. Shewell LK, Day CJ, Jen FE, Haselhorst T, Atack JM, Reijneveld JF, Everest-Dass A, James DBA, Boguslawski KM, Brouwer S, Gillen CM, Luo Z, Kobe B, Nizet V, von Itzstein M, Walker MJ, Paton AW, Paton JC, Torres VJ, Jennings MP. PMID: 32494740.
      View in: PubMed   Mentions: 14     Fields:    
    44. Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection. PLoS Genet. 2020 05; 16(5):e1008795. Kuang E, Okumura CYM, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA. PMID: 32392217.
      View in: PubMed   Mentions:    Fields:    
    45. Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract Infection. mSphere. 2020 04 22; 5(2). Patras KA, Coady A, Babu P, Shing SR, Ha AD, Rooholfada E, Brandt SL, Geriak M, Gallo RL, Nizet V. PMID: 32321824.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    46. How Neutrophils Meet Their End. Trends Immunol. 2020 06; 41(6):531-544. Lawrence SM, Corriden R, Nizet V. PMID: 32303452.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    47. Genetic Determinants Enabling Medium-Dependent Adaptation to Nafcillin in Methicillin-Resistant Staphylococcus aureus. mSystems. 2020 Mar 31; 5(2). Salazar MJ, Machado H, Dillon NA, Tsunemoto H, Szubin R, Dahesh S, Pogliano J, Sakoulas G, Palsson BO, Nizet V, Feist AM. PMID: 32234776.
      View in: PubMed   Mentions: 3  
    48. Role of peribrachial fat as a key determinant of brachial artery dilatation for successful arteriovenous fistula maturation in hemodialysis patients. Sci Rep. 2020 03 02; 10(1):3841. Lee HS, Park MJ, Yoon SY, Joo N, Song YR, Kim HJ, Kim SG, Nizet V, Kim JK. PMID: 32123226.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176.
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    50. The Fungal Pathogen Candida albicans Promotes Bladder Colonization of Group B Streptococcus. Front Cell Infect Microbiol. 2019; 9:437. Shing SR, Ramos AR, Patras KA, Riestra AM, McCabe S, Nizet V, Coady A. PMID: 31998657.
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    51. Upon microbial challenge, human neutrophils undergo rapid changes in nuclear architecture and chromatin folding to orchestrate an immediate inflammatory gene program. Genes Dev. 2020 02 01; 34(3-4):149-165. Denholtz M, Zhu Y, He Z, Lu H, Isoda T, Döhrmann S, Nizet V, Murre C. PMID: 31919189.
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    52. Siglecs at the Host-Pathogen Interface. Adv Exp Med Biol. 2020; 1204:197-214. Chang YC, Nizet V. PMID: 32152948.
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    53. Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media. Sci Data. 2019 12 17; 6(1):322. Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, Nizet V, Palsson BO, Feist AM, Pogliano J. PMID: 31848353.
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    54. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019 12 16; 10(1):5726. Valderrama JA, Kulkarni SS, Nizet V, Bier E. PMID: 31844051.
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    55. Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages. J Innate Immun. 2020; 12(4):333-343. Tsai CM, Riestra AM, Ali SR, Fong JJ, Liu JZ, Hughes G, Varki A, Nizet V. PMID: 31805552.
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    56. Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM. Virulence. 2019 12; 10(1):194-206. Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M. PMID: 30829556; PMCID: PMC6527014.
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    57. Erythrocyte-Coated Nanoparticles Block Cytotoxic Effects of Group B Streptococcus β-Hemolysin/Cytolysin. Front Pediatr. 2019; 7:410. Koo J, Escajadillo T, Zhang L, Nizet V, Lawrence SM. PMID: 31737584.
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    58. Reply to Kalil et al., "Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia?" Antimicrob Agents Chemother. 2019 11; 63(11). Sakoulas G, Geriak M, Haddad F, Rose W, LaPlante K, Zervos M, Kullar R, Nizet V. PMID: 31640978.
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    59. Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus. Appl Environ Microbiol. 2019 11 01; 85(21). Machado H, Weng LL, Dillon N, Seif Y, Holland M, Pekar JE, Monk JM, Nizet V, Palsson BO, Feist AM. PMID: 31471305.
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    60. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis. Nat Commun. 2019 10 11; 10(1):4656. Toledo AG, Golden G, Campos AR, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD. PMID: 31604940.
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    61. Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia. Clin Infect Dis. 2019 09 13; 69(7):1232-1234. Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwood K, Davies MR. PMID: 30721938.
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    62. Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease. Front Microbiol. 2019; 10:1967. Gao NJ, Al-Bassam MM, Poudel S, Wozniak JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA. PMID: 31507572.
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    63. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 2019 08 13; 8. Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PMID: 31408005.
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    64. Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens. EBioMedicine. 2019 Aug; 46:193-201. Dillon N, Holland M, Tsunemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V. PMID: 31353294.
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    65. Inflammasome inhibition blocks cardiac glycoside cell toxicity. J Biol Chem. 2019 08 23; 294(34):12846-12854. LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN. PMID: 31300552.
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    66. Avibactam Sensitizes Carbapenem-Resistant NDM-1-Producing Klebsiella pneumoniae to Innate Immune Clearance. J Infect Dis. 2019 07 02; 220(3):484-493. Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V. PMID: 30923801.
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    67. Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin. Antimicrob Agents Chemother. 2019 07; 63(7). Dahesh S, Wong B, Nizet V, Sakoulas G, Tran TT, Aitken SL. PMID: 31235559.
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    68. Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli. J Innate Immun. 2019; 11(6):481-495. Patras KA, Ha AD, Rooholfada E, Olson J, Ramachandra Rao SP, Lin AE, Nizet V. PMID: 31055580.
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    69. An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model. mBio. 2019 04 30; 10(2). Rivera-Hernandez T, Carnathan DG, Jones S, Cork AJ, Davies MR, Moyle PM, Toth I, Batzloff MR, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. PMID: 31040243.
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    70. Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media. Sci Data. 2019 04 26; 6(1):43. Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Pogliano J, Knight R, Nizet V, Palsson BO, Feist AM. PMID: 31028276; PMCID: PMC6486602.
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    71. Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2019 05; 63(5). Geriak M, Haddad F, Rizvi K, Rose W, Kullar R, LaPlante K, Yu M, Vasina L, Ouellette K, Zervos M, Nizet V, Sakoulas G. PMID: 30858203; PMCID: PMC6496065.
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    72. Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion. Front Pharmacol. 2019; 10:323. Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. PMID: 31024300; PMCID: PMC6460395.
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    73. The long noncoding RNA ROCKI regulates inflammatory gene expression. EMBO J. 2019 04 15; 38(8). Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM. PMID: 30918008; PMCID: PMC6463213.
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    74. Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7465-7470. Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V. PMID: 30910970.
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    75. Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia. Therap Adv Gastroenterol. 2019; 12:1756284819834273. Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G. PMID: 30923573; PMCID: PMC6431768.
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    76. Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry. Cell Chem Biol. 2019 05 16; 26(5):724-736.e7. Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS. PMID: 30853419.
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    77. Impact of Anesthetics on Human Neutrophil Function. Anesth Analg. 2019 03; 128(3):569-574. Meier A, Nizet V. PMID: 30507837.
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    78. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria. Chem Biol Drug Des. 2019 04; 93(4):647-652. Huang YM, Munguia J, Miao Y, Nizet V, McCammon JA. PMID: 30570806.
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    79. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Sci Transl Med. 2019 02 06; 11(478). Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. PMID: 30728285; PMCID: PMC6561727.
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    80. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019 03; 26(3):395-408. Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. PMID: 30622307.
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    81. Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics? Clin Infect Dis. 2019 01 01; 68(1):157-164. Sakoulas G, Geriak M, Nizet V. PMID: 29986019; PMCID: PMC6293005.
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    82. Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection. Toxins (Basel). 2018 12 17; 10(12). Escajadillo T, Nizet V. PMID: 30562923.
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    83. The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus. BMC Microbiol. 2018 11 26; 18(1):197. Vrbanac A, Riestra AM, Coady A, Knight R, Nizet V, Patras KA. PMID: 30477439.
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    84. Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". Antimicrob Agents Chemother. 2018 12; 62(12). Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. PMID: 30478181.
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    85. Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans. Infect Immun. 2018 12; 86(12). Coady A, Ramos AR, Olson J, Nizet V, Patras KA. PMID: 30297523.
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    86. Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. J Innate Immun. 2019; 11(1):86-98. Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. PMID: 30391945.
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    87. Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization. Int J Pharm. 2019 Jan 10; 554:81-86. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Uchiyama S, Dahesh S, Nizet V, Kessler J. PMID: 30395958.
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    88. Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. Nat Commun. 2018 10 17; 9(1):4306. Kavvas ES, Catoiu E, Mih N, Yurkovich JT, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk JM, Palsson BO. PMID: 30333483.
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    89. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog. 2018 10; 14(10):e1007348. van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. PMID: 30321240.
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    90. Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis. . 2018 10 10; 24(4):500-513.e5. Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD. PMID: 30308156.
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    91. Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance. J Infect Dis. 2018 10 05; 218(10):1641-1652. Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V. PMID: 29868829.
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    92. Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10410-10415. Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD. PMID: 30254166.
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    93. Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors. FEMS Microbiol Rev. 2018 09 01; 42(5):656-671. Askarian F, Wagner T, Johannessen M, Nizet V. PMID: 29893825; PMCID: PMC6098222.
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    94. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. PMID: 29912959; PMCID: PMC6023241.
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    95. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. PMID: 29514266.
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    96. Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device. Appl Microbiol Biotechnol. 2018 Aug; 102(15):6459-6467. Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J. PMID: 29804135.
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    97. Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP. Front Cell Infect Microbiol. 2018; 8:160. Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ. PMID: 29868516; PMCID: PMC5966554.
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    98. Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Front Med (Lausanne). 2018; 5:131. Gupta N, Nizet V. PMID: 29780805.
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    99. Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis. Benef Microbes. 2018 Apr 25; 9(3):429-439. van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S. PMID: 29633637.
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    100. Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit. Front Immunol. 2018; 9:679. Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M. PMID: 29686674; PMCID: PMC5900007.
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    101. Humanized Exposures of a β-Lactam-β-Lactamase Inhibitor, Tazobactam, versus Non-β-Lactam-β-Lactamase Inhibitor, Avibactam, with or without Colistin, against Acinetobacter baumannii in Murine Thigh and Lung Infection Models. Pharmacology. 2018; 101(5-6):255-261. Monogue ML, Sakoulas G, Nizet V, Nicolau DP. PMID: 29533955.
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    102. Telavancin for refractory MRSA bacteraemia in intermittent haemodialysis recipients. J Antimicrob Chemother. 2018 03 01; 73(3):764-767. Britt NS, Tirmizi S, Ritchie DJ, Topal JE, McManus D, Nizet V, Casabar E, Sakoulas G. PMID: 29244141.
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    103. Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches. Front Pediatr. 2018; 6:27. Patras KA, Nizet V. PMID: 29520354; PMCID: PMC5827363.
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    104. Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa. Sci Rep. 2018 02 21; 8(1):3437. Haripriyan J, Omanakuttan A, Menon ND, Vanuopadath M, Nair SS, Corriden R, Nair BG, Nizet V, Kumar GB. PMID: 29467483; PMCID: PMC5821892.
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    105. Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models. Front Microbiol. 2018; 9:262. Askarian F, Lapek JD, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M. PMID: 29515544.
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    106. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. PMID: 29396891.
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    107. Broad-Spectrum Neutralization of Pore-Forming Toxins with Human Erythrocyte Membrane-Coated Nanosponges. Adv Healthc Mater. 2018 07; 7(13):e1701366. Chen Y, Chen M, Zhang Y, Lee JH, Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang L. PMID: 29436150.
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    108. The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis. Microbiol Mol Biol Rev. 2018 06; 82(1). Lawrence SM, Corriden R, Nizet V. PMID: 29436479; PMCID: PMC5813886.
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    109. Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance. Sci Rep. 2018 02 02; 8(1):2215. Choe D, Szubin R, Dahesh S, Cho S, Nizet V, Palsson B, Cho BK. PMID: 29396540.
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    110. Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus. mBio. 2018 01 30; 9(1). Henningham A, Davies MR, Uchiyama S, van Sorge NM, Lund S, Chen KT, Walker MJ, Cole JN, Nizet V. PMID: 29382733.
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    111. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018; 8:2. Liu JZ, Ali SR, Bier E, Nizet V. PMID: 29404280; PMCID: PMC5786542.
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    176. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J. 2015 Nov 12; 34(22):2775-88. Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A, Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. PMID: 26459514; PMCID: PMC4682649.
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    179. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J, Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. PMID: 26391660; PMCID: PMC4586747.
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    180. Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PLoS One. 2015; 10(8):e0136605. Pence MA, Haste NM, Meharena HS, Olson J, Gallo RL, Nizet V, Kristian SA, Pence MA, Haste NM, Meharena HS, Olson J, Gallo RL, Nizet V, Kristian SA. PMID: 26305782; PMCID: PMC4549145.
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    181. Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics. Antimicrob Agents Chemother. 2015 Oct; 59(10):6132-9. Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V, Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V. PMID: 26195528; PMCID: PMC4576044.
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    182. Stopping superbugs, maintaining the microbiota. Sci Transl Med. 2015 Jul 08; 7(295):295ed8. Nizet V, Nizet V. PMID: 26157027.
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    183. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC, Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. PMID: 26150541; PMCID: PMC4534644.
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    184. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chem Biol. 2015 Jun 18; 22(6):785-92. Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL, Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. PMID: 26091171; PMCID: PMC4475277.
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    185. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. EBioMedicine. 2015 Jul; 2(7):690-8. Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V, Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V. PMID: 26288841; PMCID: PMC4534682.
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    186. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS, Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS. PMID: 25930739; PMCID: PMC4545249.
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    187. In vitro activity of daptomycin in combination with β-lactams, gentamicin, rifampin, and tigecycline against daptomycin-nonsusceptible enterococci. Antimicrob Agents Chemother. 2015 Jul; 59(7):4279-88. Hindler JA, Wong-Beringer A, Charlton CL, Miller SA, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R, Hindler JA, Wong-Beringer A, Charlton CL, Miller SA, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R. PMID: 25963982; PMCID: PMC4468720.
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    188. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med (Berl). 2015 Jun; 93(6):619-31. Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V, Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. PMID: 25940316; PMCID: PMC4469262.
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    189. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr; 11(4):e1004818. Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V, Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. PMID: 25927232; PMCID: PMC4415805.
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    190. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE, McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE. PMID: 25824841; PMCID: PMC4432760.
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    191. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4453-8. Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F, Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. PMID: 25831516; PMCID: PMC4394260.
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    194. Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics. Antimicrob Agents Chemother. 2015 May; 59(5):2799-806. Berti AD, Baines SL, Howden BP, Sakoulas G, Nizet V, Proctor RA, Rose WE, Berti AD, Baines SL, Howden BP, Sakoulas G, Nizet V, Proctor RA, Rose WE. PMID: 25733508; PMCID: PMC4394801.
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    195. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015 Apr 01; 194(7):3259-66. Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E, Peyssonnaux C, Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E, Peyssonnaux C. PMID: 25710915.
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    199. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V, Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. PMID: 25630970; PMCID: PMC4771066.
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    201. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell. 2015 Jan 08; 57(1):55-68. Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M, Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. PMID: 25544559; PMCID: PMC4373083.
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    220. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III). Mar Drugs. 2014 Apr 30; 12(5):2458-70. Liu Y, Haste NM, Thienphrapa W, Li J, Nizet V, Hensler M, Li R, Liu Y, Haste NM, Thienphrapa W, Li J, Nizet V, Hensler M, Li R. PMID: 24796304; PMCID: PMC4052300.
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    223. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5520-5. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE, Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE. PMID: 24706917; PMCID: PMC3992636.
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    225. Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics. 2014 May; 13(5):1262-72. Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon JE, Dorrestein PC, Nizet V, Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon JE, Dorrestein PC, Nizet V. PMID: 24567418; PMCID: PMC4014283.
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    226. Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ. PLoS One. 2014; 9(2):e89284. Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK, Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK. PMID: 24586659; PMCID: PMC3930702.
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    227. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V, Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V. PMID: 24586650; PMCID: PMC3929751.
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    234. Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2014; 58(3):1494-500. Sakoulas G, Rose W, Nonejuie P, Olson J, Pogliano J, Humphries R, Nizet V, Sakoulas G, Rose W, Nonejuie P, Olson J, Pogliano J, Humphries R, Nizet V. PMID: 24366742; PMCID: PMC3957885.
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    235. Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun. 2014 Mar; 82(3):1132-40. Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM, Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM. PMID: 24366250; PMCID: PMC3957989.
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    236. The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus. J Biol Chem. 2014 Feb 07; 289(6):3539-46. Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V, Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V. PMID: 24356958; PMCID: PMC3916555.
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    238. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014 Mar; 28(3):1280-93. Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T, Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. PMID: 24308974; PMCID: PMC3929681.
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    239. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl). 2014 Feb; 92(2):139-49. Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS, Nizet V, Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS, Nizet V. PMID: 24297496; PMCID: PMC3926703.
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    240. Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20218-23. Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Lardone RD, Le D, Varki NM, Nizet V, Marth JD, Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Lardone RD, Le D, Varki NM, Nizet V, Marth JD. PMID: 24284176; PMCID: PMC3864324.
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    241. Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study. Ann Intern Med. 2013 Nov 05; 159(9):577-83. Fine AM, Nizet V, Mandl KD, Fine AM, Nizet V, Mandl KD. PMID: 24189592; PMCID: PMC3953456.
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    242. Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4407-16. Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS, Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS. PMID: 24191063; PMCID: PMC3839717.
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    243. Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One. 2013; 8(10):e77282. Yamaguchi M, Terao Y, Mori-Yamaguchi Y, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S, Yamaguchi M, Terao Y, Mori-Yamaguchi Y, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S. PMID: 24194877; PMCID: PMC3806730.
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    244. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17570-5. Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS, Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. PMID: 24101470; PMCID: PMC3808605.
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    245. EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein. Biochem J. 2013 Oct 01; 455(1):107-18. Sjögren J, Struwe WB, Cosgrave EF, Rudd PM, Stervander M, Allhorn M, Hollands A, Nizet V, Collin M, Sjögren J, Struwe WB, Cosgrave EF, Rudd PM, Stervander M, Allhorn M, Hollands A, Nizet V, Collin M. PMID: 23865566; PMCID: PMC3778708.
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    246. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Dermatol. 2014 Mar; 134(3):801-808. Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS, Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. PMID: 24037341; PMCID: PMC3877686.
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    253. β-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Oct; 57(10):5005-12. Berti AD, Sakoulas G, Nizet V, Tewhey R, Rose WE, Berti AD, Sakoulas G, Nizet V, Tewhey R, Rose WE. PMID: 23896478; PMCID: PMC3811465.
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    254. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLoS Pathog. 2013; 9(7):e1003469. Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ, Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ. PMID: 23853591; PMCID: PMC3701706.
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    256. Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline. Antimicrob Agents Chemother. 2013 Aug; 57(8):4042-5. Sakoulas G, Nonejuie P, Nizet V, Pogliano J, Crum-Cianflone N, Haddad F, Sakoulas G, Nonejuie P, Nizet V, Pogliano J, Crum-Cianflone N, Haddad F. PMID: 23689728; PMCID: PMC3719745.
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    257. HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med (Berl). 2013 Oct; 91(10):1199-205. Bhandari T, Olson J, Johnson RS, Nizet V, Bhandari T, Olson J, Johnson RS, Nizet V. PMID: 23686259; PMCID: PMC3783576.
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    260. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature. 2013 Apr 11; 496(7444):238-42. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA, Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. PMID: 23535595; PMCID: PMC4031686.
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    265. Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem. 2013 Mar 01; 288(9):6417-26. van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, Nudler E, Nizet V, van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, Nudler E, Nizet V. PMID: 23322784; PMCID: PMC3585076.
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    267. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):123-8. Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E, Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. PMID: 23248302; PMCID: PMC3538244.
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    285. Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy. Genes Dev. 2012 May 15; 26(10):1041-54. Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC, Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC. PMID: 22588718; PMCID: PMC3360560.
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    286. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (I). Mar Drugs. 2012 Apr; 10(4):953-62. Liu Y, Haste NM, Thienphrapa W, Nizet V, Hensler M, Li R, Liu Y, Haste NM, Thienphrapa W, Nizet V, Hensler M, Li R. PMID: 22690153; PMCID: PMC3366685.
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    288. Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile. PLoS One. 2012; 7(4):e35218. Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Janos M, Nizet V, Kotb M, Norrby-Teglund A, Hertzén E, Johansson L, Kansal R, Hecht A, Dahesh S, Janos M, Nizet V, Kotb M, Norrby-Teglund A. PMID: 22511985; PMCID: PMC3325220.
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    289. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012 Apr 03; 3(5):402-406. Zhang Y, Fu-Yang Lin , Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E, Zhang Y, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. PMID: 22662288; PMCID: PMC3363326.
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    319. Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature. 2011 Apr 07; 472(7341):64-8. Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P, Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P. PMID: 21475196; PMCID: PMC3268815.
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    320. Papillation in Bacillus anthracis colonies: a tool for finding new mutators. Mol Microbiol. 2011 Mar; 79(5):1276-93. Yang H, Sikavi C, Tran K, McGillivray SM, Nizet V, Yung M, Chang A, Miller JH, Yang H, Sikavi C, Tran K, McGillivray SM, Nizet V, Yung M, Chang A, Miller JH. PMID: 21205011.
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    323. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe. 2010 Nov 18; 8(5):445-54. Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet V, Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass CK, Nizet V. PMID: 21075355; PMCID: PMC3008410.
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    324. Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Nature. 2010 Oct 14; 467(7317):854-8. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E, Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. PMID: 20944747; PMCID: PMC5831355.
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    325. Bacteria and phagocytes: mortal enemies. J Innate Immun. 2010; 2(6):505-7. Nizet V, Nizet V. PMID: 20829606.
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    326. Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun. 2010; 2(6):576-86. Berends ET, Horswill AR, Haste NM, Monestier M, Nizet V, von Köckritz-Blickwede M, Berends ET, Horswill AR, Haste NM, Monestier M, Nizet V, von Köckritz-Blickwede M. PMID: 20829609; PMCID: PMC2982853.
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    327. Parameters governing invasive disease propensity of non-M1 serotype group A streptococci. J Innate Immun. 2010; 2(6):596-606. Maamary PG, Sanderson-Smith ML, Aziz RK, Hollands A, Cole JN, McKay FC, McArthur JD, Kirk JK, Cork AJ, Keefe RJ, Kansal RG, Sun H, Taylor WL, Chhatwal GS, Ginsburg D, Nizet V, Kotb M, Walker MJ, Maamary PG, Sanderson-Smith ML, Aziz RK, Hollands A, Cole JN, McKay FC, McArthur JD, Kirk JK, Cork AJ, Keefe RJ, Kansal RG, Sun H, Taylor WL, Chhatwal GS, Ginsburg D, Nizet V, Kotb M, Walker MJ. PMID: 20814186; PMCID: PMC3219504.
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    328. Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus. J Innate Immun. 2010; 2(6):587-95. Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V, Pence MA, Rooijakkers SH, Cogen AL, Cole JN, Hollands A, Gallo RL, Nizet V. PMID: 20814187; PMCID: PMC3219503.
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    329. M protein and hyaluronic acid capsule are essential for in vivo selection of covRS mutations characteristic of invasive serotype M1T1 group A Streptococcus. mBio. 2010 Aug 31; 1(4). Cole JN, Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL, Walker MJ, Nizet V, Cole JN, Pence MA, von Köckritz-Blickwede M, Hollands A, Gallo RL, Walker MJ, Nizet V. PMID: 20827373; PMCID: PMC2934611.
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    330. Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16286-90. Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez D, Ellermeier CD, Straight PD, Pevzner PA, Pogliano J, Nizet V, Pogliano K, Dorrestein PC, Liu WT, Yang YL, Xu Y, Lamsa A, Haste NM, Yang JY, Ng J, Gonzalez D, Ellermeier CD, Straight PD, Pevzner PA, Pogliano J, Nizet V, Pogliano K, Dorrestein PC. PMID: 20805502; PMCID: PMC2941286.
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    331. On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5701-4. Derbal S, Hensler M, Fang W, Nizet V, Ghedira K, Nefzi A, Derbal S, Hensler M, Fang W, Nizet V, Ghedira K, Nefzi A. PMID: 20800485; PMCID: PMC2963184.
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    332. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. Zhao HW, Zhou D, Nizet V, Haddad GG, Zhao HW, Zhou D, Nizet V, Haddad GG. PMID: 20668515; PMCID: PMC2909141.
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    333. Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med. 2010 Aug 02; 207(8):1637-46. Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A, Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A. PMID: 20624889; PMCID: PMC2916132.
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    334. Human transferrin confers serum resistance against Bacillus anthracis. J Biol Chem. 2010 Sep 03; 285(36):27609-13. Rooijakkers SH, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V, Rooijakkers SH, Rasmussen SL, McGillivray SM, Bartnikas TB, Mason AB, Friedlander AM, Nizet V. PMID: 20615872; PMCID: PMC2934628.
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    335. Genetic switch to hypervirulence reduces colonization phenotypes of the globally disseminated group A streptococcus M1T1 clone. J Infect Dis. 2010 Jul 01; 202(1):11-9. Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V, Hollands A, Pence MA, Timmer AM, Osvath SR, Turnbull L, Whitchurch CB, Walker MJ, Nizet V. PMID: 20507231; PMCID: PMC2880657.
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    336. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 03; 285(36):28220-8. Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC, Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC. PMID: 20581111; PMCID: PMC2934687.
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    337. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. J Biol Chem. 2010 Sep 03; 285(36):27798-805. Kaur SJ, Nerlich A, Bergmann S, Rohde M, Fulde M, Zähner D, Hanski E, Zinkernagel A, Nizet V, Chhatwal GS, Talay SR, Kaur SJ, Nerlich A, Bergmann S, Rohde M, Fulde M, Zähner D, Hanski E, Zinkernagel A, Nizet V, Chhatwal GS, Talay SR. PMID: 20562101; PMCID: PMC2934647.
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    338. O-Acetylation of sialic acid on Group B Streptococcus inhibits neutrophil suppression and virulence. Biochem J. 2010 May 13; 428(2):163-8. Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL, Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. PMID: 20334627; PMCID: PMC3640289.
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    339. Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2010 May; 63(5):219-24. Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME, Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME. PMID: 20339399; PMCID: PMC2889693.
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    340. Evaluation of Streptococcus iniae killed bacterin and live attenuated vaccines in hybrid striped bass through injection and bath immersion. Dis Aquat Organ. 2010 Mar 09; 89(2):117-23. Locke JB, Vicknair MR, Ostland VE, Nizet V, Buchanan JT, Locke JB, Vicknair MR, Ostland VE, Nizet V, Buchanan JT. PMID: 20402229.
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    341. Accentuate the (Gram) positive. J Mol Med (Berl). 2010 Feb; 88(2):93-5. Nizet V, Nizet V. PMID: 20174776.
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    342. Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract. Mol Microbiol. 2010 Jun; 76(6):1387-97. Kurupati P, Turner CE, Tziona I, Lawrenson RA, Alam FM, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ, Sriskandan S, Kurupati P, Turner CE, Tziona I, Lawrenson RA, Alam FM, Nohadani M, Stamp GW, Zinkernagel AS, Nizet V, Edwards RJ, Sriskandan S. PMID: 20158613; PMCID: PMC2904501.
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    343. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4329-34. Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS, Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS. PMID: 20142499; PMCID: PMC2840078.
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    344. Pathogen microevolution in high resolution. Sci Transl Med. 2010 Jan 27; 2(16):16ps4. Aziz RK, Nizet V, Aziz RK, Nizet V. PMID: 20371473.
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    345. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010 Jan 05; 5(1):e8557. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL, Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. PMID: 20052280; PMCID: PMC2796718.
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    346. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol. 2010 Jan; 130(1):192-200. Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, MacLeod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL, Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, MacLeod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. PMID: 19710683; PMCID: PMC2796468.
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    347. Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps. Blood. 2009 Dec 10; 114(25):5245-6. von Köckritz-Blickwede M, Chow OA, Nizet V, von Köckritz-Blickwede M, Chow OA, Nizet V. PMID: 20007813; PMCID: PMC2792215.
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    348. M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl). 2010 Apr; 88(4):371-81. Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V, Crotty Alexander LE, Maisey HC, Timmer AM, Rooijakkers SH, Gallo RL, von Köckritz-Blickwede M, Nizet V. PMID: 19960175; PMCID: PMC2843839.
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    349. The novel polysaccharide deacetylase homologue Pdi contributes to virulence of the aquatic pathogen Streptococcus iniae. Microbiology (Reading). 2010 Feb; 156(Pt 2):543-554. Milani CJE, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT, Milani CJE, Aziz RK, Locke JB, Dahesh S, Nizet V, Buchanan JT. PMID: 19762441; PMCID: PMC2890087.
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    350. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol. 2009 Sep; 9(9):609-17. Nizet V, Johnson RS, Nizet V, Johnson RS. PMID: 19704417; PMCID: PMC4343208.
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    351. Color me bad: microbial pigments as virulence factors. Trends Microbiol. 2009 Sep; 17(9):406-13. Liu GY, Nizet V, Liu GY, Nizet V. PMID: 19726196; PMCID: PMC2743764.
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    352. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med. 2009 Aug 31; 206(9):1845-52. Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V, Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. PMID: 19687228; PMCID: PMC2737157.
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    353. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 2009 Nov; 19(11):1204-13. Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL, Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. PMID: 19643844; PMCID: PMC2757575.
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    354. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A, Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. PMID: 19666579; PMCID: PMC2726416.
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    355. Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin. J Leukoc Biol. 2009 Nov; 86(5):1159-69. Jann NJ, Schmaler M, Kristian SA, Radek KA, Gallo RL, Nizet V, Peschel A, Landmann R, Jann NJ, Schmaler M, Kristian SA, Radek KA, Gallo RL, Nizet V, Peschel A, Landmann R. PMID: 19638500; PMCID: PMC3192022.
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    356. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One. 2009 Jul 27; 4(7):e6387. Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY, Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. PMID: 19633710; PMCID: PMC2711303.
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    357. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009 Aug 03; 206(8):1691-9. Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V, Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. PMID: 19596804; PMCID: PMC2722167.
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    360. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L, Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630; PMCID: PMC2722361.
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    362. The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis. 2009 May 15; 199(10):1479-87. van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS, van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS. PMID: 19392623; PMCID: PMC2674616.
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    363. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One. 2009; 4(4):e5366. Cox KH, Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz RK, Gerling I, Price SM, Hasty DL, Cox KH, Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz RK, Gerling I, Price SM, Hasty DL. PMID: 19401780; PMCID: PMC2671602.
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    364. Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling. Immunol Cell Biol. 2009 Aug-Sep; 87(6):496-500. Pinheiro da Silva F, Gallo RL, Nizet V, Pinheiro da Silva F, Gallo RL, Nizet V. PMID: 19350049; PMCID: PMC2763337.
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    365. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7107-12. Navarini AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM, Navarini AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM. PMID: 19351895; PMCID: PMC2678456.
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    366. Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis. 2009 Apr; 14(4):509-21. Pinheiro da Silva F, Nizet V, Pinheiro da Silva F, Nizet V. PMID: 19199035.
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    367. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem. 2009 May 08; 284(19):13004-12. Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE, Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. PMID: 19286651; PMCID: PMC2676033.
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    368. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26; 52(4):976-88. Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E, Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. PMID: 19191557; PMCID: PMC2765255.
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    369. M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 2009; 1(3):202-14. Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V, Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. PMID: 20375578; PMCID: PMC3241932.
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    370. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A, Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. PMID: 19196661; PMCID: PMC2665898.
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    371. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis. 2009 Feb; 15(2):223-32. Sendi P, Johansson L, Dahesh S, Van-Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A, Sendi P, Johansson L, Dahesh S, Van-Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A. PMID: 19193266; PMCID: PMC2657631.
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    372. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One. 2009; 4(1):e4166. Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielski A, Podbielbski A, Hasty DL, Dale JB, Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielski A, Podbielbski A, Hasty DL, Dale JB. PMID: 19132104; PMCID: PMC2613554.
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    373. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One. 2008; 3(12):e4102. Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ, Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. PMID: 19116661; PMCID: PMC2605554.
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    374. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V, Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. PMID: 19001420; PMCID: PMC2613605.
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    375. Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med. 2008 Sep 22; 10:e27. Maisey HC, Doran KS, Nizet V, Maisey HC, Doran KS, Nizet V. PMID: 18803886; PMCID: PMC2676346.
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    376. Mitochondrial missile defense. Nat Med. 2008 Sep; 14(9):910-2. Nizet V, Rothenberg ME, Nizet V, Rothenberg ME. PMID: 18776879.
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    377. The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing. Cell Host Microbe. 2008 Aug 14; 4(2):170-8. Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V, Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V. PMID: 18692776; PMCID: PMC2631432.
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    378. Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. PLoS One. 2008 Jul 30; 3(7):e2824. Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT, Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT. PMID: 18665241; PMCID: PMC2483786.
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    379. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One. 2008 Jun 18; 3(6):e2446. Hensler ME, Miyamoto S, Nizet V, Hensler ME, Miyamoto S, Nizet V. PMID: 18560574; PMCID: PMC2409074.
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    380. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob Agents Chemother. 2008 Aug; 52(8):2915-8. Dahesh S, Hensler ME, Van Sorge NM, Gertz RE, Schrag S, Nizet V, Beall BW, Dahesh S, Hensler ME, Van Sorge NM, Gertz RE, Schrag S, Nizet V, Beall BW. PMID: 18541727; PMCID: PMC2493126.
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    381. The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses. BMC Microbiol. 2008 Jun 02; 8:85. Kraus D, Herbert S, Kristian SA, Khosravi A, Nizet V, Götz F, Peschel A, Kraus D, Herbert S, Kristian SA, Khosravi A, Nizet V, Götz F, Peschel A. PMID: 18518949; PMCID: PMC2430206.
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    382. IKKbeta/NF-kappaB and the miscreant macrophage. J Exp Med. 2008 Jun 09; 205(6):1255-9. Timmer AM, Nizet V, Timmer AM, Nizet V. PMID: 18519650; PMCID: PMC2413023.
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    383. Innate barriers against infection and associated disorders. Drug Discov Today Dis Mech. 2008 Jun 01; 5(2):145-152. Gallo RL, Nizet V, Gallo RL, Nizet V. PMID: 19492071; PMCID: PMC2664251.
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    384. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M, Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. PMID: 18511561; PMCID: PMC2409384.
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    385. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008 Jun; 14(6):648-55. Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD, Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. PMID: 18488037; PMCID: PMC2853759.
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    386. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M, Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192; PMCID: PMC2669289.
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    387. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE, Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. PMID: 18375757; PMCID: PMC2311365.
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    388. Strain-associated virulence factors of Streptococcus iniae in hybrid-striped bass. Vet Microbiol. 2008 Sep 18; 131(1-2):145-53. Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V, Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V. PMID: 18406547.
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    389. Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence. Science. 2008 Mar 07; 319(5868):1405-8. McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P, McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. PMID: 18323455; PMCID: PMC2288698.
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    390. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol. 2008 Aug; 128(8):1964-8. Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson RS, Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson RS. PMID: 18323789.
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    391. Skin microbiota: a source of disease or defence? Br J Dermatol. 2008 Mar; 158(3):442-55. Cogen AL, Nizet V, Gallo RL, Cogen AL, Nizet V, Gallo RL. PMID: 18275522; PMCID: PMC2746716.
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    392. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 07; 319(5868):1391-4. Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E, Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. PMID: 18276850; PMCID: PMC2747771.
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    393. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol. 2008 Apr; 190(7):2275-8. Park B, Nizet V, Liu GY, Park B, Nizet V, Liu GY. PMID: 18223076; PMCID: PMC2293205.
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    394. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J. 2008 Jun; 22(6):1715-24. Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran KS, Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran KS. PMID: 18198218; PMCID: PMC2721339.
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    395. Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis. 2008 Jan 15; 197(2):214-7. Zinkernagel AS, Peyssonnaux C, Johnson RS, Nizet V, Zinkernagel AS, Peyssonnaux C, Johnson RS, Nizet V. PMID: 18173364.
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    396. Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem. 2008 Mar 07; 283(10):6359-66. Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, Walker MJ, Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, Walker MJ. PMID: 18180300.
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    397. Role of the hypoxia inducible factors HIF in iron metabolism. . 2008 Jan 01; 7(1):28-32. Peyssonnaux C, Nizet V, Johnson RS, Peyssonnaux C, Nizet V, Johnson RS. PMID: 18212530.
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    398. Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics. 2007 Dec; 7(24):4488-98. Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ, Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ. PMID: 18072207.
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    399. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl). 2007 Dec; 85(12):1339-46. Zinkernagel AS, Johnson RS, Nizet V, Zinkernagel AS, Johnson RS, Nizet V. PMID: 18030436.
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    400. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett. 2008 May 15; 18(10):3107-11. Meluzzi D, Zheng WH, Hensler M, Nizet V, Dorrestein PC, Meluzzi D, Zheng WH, Hensler M, Nizet V, Dorrestein PC. PMID: 18006314; PMCID: PMC2519147.
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    401. CAMP factor is not essential for systemic virulence of Group B Streptococcus. Microb Pathog. 2008 Jan; 44(1):84-8. Hensler ME, Quach D, Hsieh CJ, Doran KS, Nizet V, Hensler ME, Quach D, Hsieh CJ, Doran KS, Nizet V. PMID: 17870297; PMCID: PMC2247369.
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    402. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V, Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. PMID: 17646166; PMCID: PMC2588433.
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    403. DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med. 2007 Aug; 13(8):981-5. Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V, Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V. PMID: 17632528.
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    404. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007 Oct 15; 110(8):3039-48. Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK, Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK. PMID: 17606764.
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    405. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. J Allergy Clin Immunol. 2007 Jul; 120(1):13-22. Nizet V, Nizet V. PMID: 17606031.
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    406. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007 Jul; 117(7):1926-32. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS, Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. PMID: 17557118; PMCID: PMC1884690.
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    407. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007 Jun 15; 178(12):7516-9. Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V, Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. PMID: 17548584.
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    408. Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ. 2007 Jun 07; 76(1):17-26. Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT, Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. PMID: 17718161.
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    409. Staphylococcus aureus: a blemish on skin immunity. . 2007 May 17; 1(3):161-2. Zinkernagel AS, Nizet V, Zinkernagel AS, Nizet V. PMID: 18005694.
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    410. How group A Streptococcus circumvents host phagocyte defenses. Future Microbiol. 2007 Feb; 2(1):75-84. Kwinn LA, Nizet V, Kwinn LA, Nizet V. PMID: 17661677.
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    411. Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. FASEB J. 2007 Apr; 21(4):1107-16. Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V, Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V. PMID: 17215486.
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    412. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG, Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. PMID: 17170310.
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    413. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus. J Bacteriol. 2007 Feb; 189(4):1322-9. Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V, Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V. PMID: 17114267; PMCID: PMC1797346.
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    414. Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol. 2007 Feb; 189(4):1279-87. Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT, Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT. PMID: 17098893; PMCID: PMC1797360.
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    415. Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides. Infect Immun. 2006 Nov; 74(11):6179-87. Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL, Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL. PMID: 17057092; PMCID: PMC1695509.
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    416. Brain abscess caused by Streptococcus pyogenes in a previously healthy child. J Clin Microbiol. 2006 Dec; 44(12):4613-5. Dehority W, Uchiyama S, Khosravi A, Nizet V, Dehority W, Uchiyama S, Khosravi A, Nizet V. PMID: 17065264; PMCID: PMC1698393.
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    417. Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells. J Bacteriol. 2007 Feb; 189(4):1464-7. Maisey HC, Hensler M, Nizet V, Doran KS, Maisey HC, Hensler M, Nizet V, Doran KS. PMID: 17041051; PMCID: PMC1797338.
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    418. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. Carlin AF, Lewis AL, Varki A, Nizet V, Carlin AF, Lewis AL, Varki A, Nizet V. PMID: 16997964; PMCID: PMC1797352.
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    419. A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO J. 2006 Oct 04; 25(19):4628-37. Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A, Hanski E, Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A, Hanski E. PMID: 16977314; PMCID: PMC1589981.
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    420. Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Mol Microbiol. 2006 Oct; 62(1):15-25. Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V, Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V. PMID: 16942605.
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