Victor Nizet

Title(s)Distinguished Professor and Vice Chair for Basic Research, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Other Positions
    Title(s)Distinguished Professor, School of Pharmacy and Pharmaceutical Science


    Collapse Biography 
    Collapse Education and Training
    Reed College, Portland, ORBA05/1984Biology
    Stanford University, Stanford, CAMD05/1989Medicine
    Collapse Awards and Honors
    2023Elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE)
    2022Elected Member of the National Academy of Medicine
    2022Elected Fellow of the American Association for the Advancement of Science (AAAS)
    2022DC White Award for Interdisciplinary Research and Mentoring (Amer Soc Microbiol)
    2022ISI Highly Cited Researcher (Cross-Field) Also 2019
    2019NIH/NIAID Merit Award (R37)
    2018Inaugural UCSD Health Sciences Award for Excellence in Junior Faculty Mentoring
    2017UCSD Chancellor's Associates Award for Excellence in Research in Science & Engineering
    2013UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring
    2013Rady Children’s Hospital Award for Excellence in Research
    2012Elected to Fellowship in the American Academy of Microbiology
    2010Elected to Membership in the Association of American Physicians
    2008E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
    2008Stephen Silberstein Senior Fellow of the American Asthma Foundation
    2006Elected to Membership in the American Society for Clinical Investigation
    2006Elected to Membership in the American Pediatric Society
    2004Career Investigator Award, American Lung Association
    2004Established Investigator Award, American Heart Association
    2002Named the 39th Mallinckrodt Scholar by the Edward Mallinckrodt, Jr. Foundation
    2002Pediatric Infectious Diseases Society Young Investigator Award
    2002Elected to Membership in the Society for Pediatric Research
    2001UCSD Department of Pediatrics Commitment to Resident Education Award
    2000UCSD Department of Pediatrics Outstanding Faculty Teacher of the Year
    1993Sidney Farber Outstanding Houseofficer Award, Children’s Hospital, Boston
    1984Class of 1922 Award, Reed College, “Most Outstanding Senior Thesis”
    1984Phi Beta Kappa, Reed College

    Collapse Overview 
    Collapse Overview
    Victor Nizet is a Distinguished Professor of Pediatrics, Vice Chair for Basic Research, and Chief of the Division of Host-Microbe Systems & Therapeutics at the University of California, San Diego (UCSD) School of Medicine and Distinguished Professor at UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences. A graduate of Reed College, Dr. Nizet received his medical training at Stanford University School of Medicine, completed a Residency and Chief Residency in Pediatrics at Harvard University's Children's Hospital in Boston, Massachusetts, and a then a Fellowship in Pediatric Infectious Diseases at the University of Washington’s Children's Hospital in Seattle. Dr. Nizet is Faculty Lead for the UCSD Collaborative to Halt Antibiotic-Resistant Microbes (CHARM), a multidisciplinary research and educational program that debuted in 2019. Dr. Nizet has authored over 500 peer-reviewed publications and has collaborated with several biotechnology interests in developing new antibiotic and immune-based therapies against drug-resistant pathogens. Details of his research program can be found on the laboratory website: http://nizetlab.ucsd.edu
    Collapse Interests

    Collapse Research 
    Collapse Research Activities and Funding
    Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
    NIH P50HD106463Sep 10, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune Sensitization
    NIH R01AI145310Aug 1, 2020 - Jul 31, 2024
    Role: Principal Investigator
    Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung InnateDefenses in the Fetus and Newborn Infant
    NIH R01AI142864Jul 17, 2019 - Jun 30, 2022
    Role: Co-Principal Investigator
    C3-Dependent Intracellular Killing in Innate Immunity and Bacterial Pathogenesis
    NIH R01AI145325Mar 5, 2019 - Feb 29, 2024
    Role: Co-Principal Investigator
    2018 Streptococcal Biology Gordon Research Conference
    NIH R13AI140636Jul 1, 2018 - Jun 30, 2019
    Role: Principal Investigator
    Broad recognition of group A Streptococcus M proteins
    NIH R21AI140436May 18, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH P50HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Academic Training in Therapeutic Advancement for Child Health (ATTACH)
    NIH T32HD087978May 1, 2016 - Apr 30, 2026
    Role: Co-Principal Investigator
    Glycoprotein Remodeling in the Vasculopathy and Coagulopathy of Sepsis
    NIH R01HL125352Sep 15, 2014 - May 31, 2020
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH R01AI110713Feb 1, 2014 - Jan 31, 2020
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R56AI096837Jul 1, 2011 - Jul 31, 2019
    Role: Co-Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH R01AI096837Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    NIH R01AI093451Apr 5, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
    NIH R56AI090863Aug 2, 2010 - Jul 31, 2011
    Role: Principal Investigator
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    NIH R01AI077780Sep 1, 2008 - Jan 31, 2020
    Role: Principal Investigator
    Sialic Acid O-Acetylation in GBS Pathogenesis &Immunity
    NIH R01HD051796Apr 7, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Molecular Analyses and Interventions for Biodefense and Emerging Pathogens
    NIH U54AI057153Sep 4, 2003 - Feb 28, 2014
    Role: Co-Investigator
    Cathelicidin in Skin Immunity
    NIH R37AI052453Sep 15, 2002 - Feb 29, 2024
    Role: Co-Principal Investigator
    Cathelicidin in Skin Immunity
    NIH R01AI052453Sep 15, 2002 - Mar 31, 2018
    Role: Principal Investigator
    SLS: Molecular Basis and Role in Invasive GAS Disease
    NIH R01AI048694Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    PENETRATION OF THE BLOOD BRAIN BARRIER IN GBS MENINGITIS
    NIH R03HD037224Feb 1, 1999 - Aug 31, 2001
    Role: Principal Investigator
    MOLECULAR BASIS OF LUNG INJURY IN GBS PNEUMONIA
    NIH K08AI001451Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Combating Antibiotic Resistance Into the Next Generation (CARING)
    NIH T32AI007036Jul 1, 1976 - Jun 30, 2026
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enhanced Killing of Methicillin-Resistant Staphylococcus aureus with Ceftaroline or Vancomycin in Combination with Carbapenems. J Infect Dis. 2025 Jan 08. Jankeel A, Pérez-Parra G, Khetarpal AK, Alvarado IA, Nizet V, Sakoulas G, Ulloa ER. PMID: 39777519.
      View in: PubMed   Mentions:    Fields:    
    2. Pathobiont-driven antibody sialylation through IL-10 undermines vaccination. J Clin Invest. 2024 Dec 16; 134(24). Tsai CM, Hajam IA, Caldera JR, Chiang AW, Gonzalez C, Du X, Choudhruy B, Li H, Suzuki E, Askarian F, Clark T, Lin B, Wierzbicki IH, Riestra AM, Conrad DJ, Gonzalez DJ, Nizet V, Lewis NE, Liu GY. PMID: 39680460.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    3. Bactericidal efficacy of low dose gaseous ozone against clinically relevant multidrug-resistant bacteria. Front Microbiol. 2024; 15:1480433. Banerjee B, Thompson C, Nizet V, Bjånes E. PMID: 39723132; PMCID: PMC11668732.
      View in: PubMed   Mentions:
    4. Gut-derived PPAR-γ signaling and risk of bacterial enteric infection: insight from thiazolidinedione users in a US population-based study. medRxiv. 2024 Dec 02. Birabaharan M, Kaelber DC, Nizet V, Zarrinpar A. PMID: 39398997; PMCID: PMC11469470.
      View in: PubMed   Mentions:
    5. Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection. JCI Insight. 2024 Nov 26. Mercado-Evans V, Branthoover H, Chew C, Serchejian C, Saltzman AB, Mejia ME, Zulk JJ, Cornax I, Nizet V, Patras KA. PMID: 39589812.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Correction to "Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans". ACS Chem Biol. 2024 Nov 26. Ngo TE, Ecker A, Ryu B, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Thomas L, Dahesh S, Nizet V, Gerwick L, Gerwick WH. PMID: 39591979.
      View in: PubMed   Mentions:    Fields:    
    7. Pattern-Based Genome Mining Guides Discovery of the Antibiotic Indanopyrrole A from a Marine Streptomycete. J Nat Prod. 2024 Nov 22. Sweeney D, Bogdanov A, Chase AB, Castro-Falcón G, Trinidad-Javier A, Dahesh S, Nizet V, Jensen PR. PMID: 39575834.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. The intricate pathogenicity of Group A Streptococcus: A comprehensive update. Virulence. 2024 Dec; 15(1):2412745. Bergsten H, Nizet V. PMID: 39370779; PMCID: PMC11542602.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. M proteins of group A Streptococcus bind hyaluronic acid via arginine-arginine/serine-arginine motifs. FASEB J. 2024 Oct 31; 38(20):e70123. McEwan TB, De Oliveira DMP, Stares EK, Hartley-Tassell LE, Day CJ, Proctor EJ, Nizet V, Walker MJ, Jennings MP, Sluyter R, Sanderson-Smith ML. PMID: 39436142.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Pattern-based genome mining guides discovery of the antibiotic indanopyrrole A from a marine streptomycetef. bioRxiv. 2024 Oct 29. Sweeney D, Bogdanov A, Chase AB, Castro-Falcón G, Trinidad-Javier A, Dahesh S, Nizet V, Jensen PR. PMID: 39554111; PMCID: PMC11565753.
      View in: PubMed   Mentions:
    11. Glycan-specific IgM is critical for human immunity to Staphylococcus aureus. Cell Rep Med. 2024 Sep 17; 5(9):101734. Hendriks A, Kerkman PF, Varkila MRJ, Haitsma Mulier JLG, Ali S, Ten Doesschate T, van der Vaart TW, de Haas CJC, Aerts PC, Cremer OL, Bonten MJM, Nizet V, Liu GY, Codée JDC, Rooijakkers SHM, van Strijp JAG, van Sorge NM. PMID: 39293400; PMCID: PMC11525025.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. CCL28 modulates neutrophil responses during infection with mucosal pathogens. Elife. 2024 Aug 28; 13. Walker GT, Perez-Lopez A, Silva S, Lee MH, Bjånes E, Dillon N, Brandt SL, Gerner RR, Melchior K, Norton GJ, Argueta FA, Dela Pena F, Park L, Sosa-Hernandez VA, Cervantes-Diaz R, Romero-Ramirez S, Cartelle Gestal M, Maravillas-Montero JL, Nuccio SP, Nizet V, Raffatellu M. PMID: 39193987; PMCID: PMC11444682.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Mucins protect against Streptococcus pneumoniae virulence by suppressing pneumolysin expression. J Clin Invest. 2024 Aug 22; 134(19). Bath J, Bjånes E, Goekeri C, Hsiao J, Uzun D, Nouailles G, Nizet V, Ribbeck K. PMID: 39172520; PMCID: PMC11444151.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of Streptococcus pyogenes. mSystems. 2024 Sep 17; 9(9):e0073624. Hirose Y, Zielinski DC, Poudel S, Rychel K, Baker JL, Toya Y, Yamaguchi M, Heinken A, Thiele I, Kawabata S, Palsson BO, Nizet V. PMID: 39158303; PMCID: PMC11406949.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Neutrophil Extracellular Traps: An Emerging Therapeutic Target to Improve Infectious Disease Outcomes. J Infect Dis. 2024 Aug 16; 230(2):514-521. Meier A, Sakoulas G, Nizet V, Ulloa ER. PMID: 38728418; PMCID: PMC11326844.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. SkinCom, a synthetic skin microbial community, enables reproducible investigations of the human skin microbiome. Cell Rep Methods. 2024 Aug 19; 4(8):100832. Lekbua A, Thiruppathy D, Coker J, Weng Y, Askarian F, Kousha A, Marotz C, Hauw A, Nizet V, Zengler K. PMID: 39111313; PMCID: PMC11384088.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Human microglial cells as a therapeutic target in a neurodevelopmental disease model. Stem Cell Reports. 2024 Aug 13; 19(8):1074-1091. Mesci P, LaRock CN, Jeziorski JJ, Nakashima H, Chermont N, Ferrasa A, Herai RH, Ozaki T, Saleh A, Snethlage CE, Sanchez S, Goldberg G, Trujillo CA, Nakashima K, Nizet V, Muotri AR. PMID: 39059378; PMCID: PMC11368698.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med. 2024 07 03; 16(754):eadi6887. Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, Crotty Alexander LE, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. PMID: 38959328; PMCID: PMC11272418.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    19. An efficient in vivo-inducible CRISPR interference system for group A Streptococcus genetic analysis and pathogenesis studies. mBio. 2024 Aug 14; 15(8):e0084024. Bjånes E, Stream A, Janssen AB, Gibson PS, Bravo AM, Dahesh S, Baker JL, Varble A, Nizet V, Veening J-W. PMID: 38953375; PMCID: PMC11323564.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Exploring roles of the chitinase ChiC in modulating Pseudomonas aeruginosa virulence phenotypes. Microbiol Spectr. 2024 Jul 02; 12(7):e0054624. Edvardsen PKT, Askarian F, Zurich R, Nizet V, Vaaje-Kolstad G. PMID: 38819151; PMCID: PMC11218509.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. The Prospect of Biomimetic Immune Cell Membrane-Coated Nanomedicines for Treatment of Serious Bacterial Infections and Sepsis. J Pharmacol Exp Ther. 2024 05 21; 389(3):289-300. Hoffman A, Nizet V. PMID: 38580449; PMCID: PMC11125797.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    22. Sialic Acid-Siglec-E Interactions Regulate the Response of Neonatal Macrophages to Group B Streptococcus. Immunohorizons. 2024 May 01; 8(5):384-396. Lund SJ, Del Rosario PGB, Honda A, Caoili KJ, Hoeksema MA, Nizet V, Patras KA, Prince LS. PMID: 38809232; PMCID: PMC11150127.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens. Infect Microbes Dis. 2024 Jun; 6(2):65-73. Stream A, Corriden R, Döhrmann S, Gallo RL, Nizet V, Anderson EL. PMID: 38952747; PMCID: PMC11216695.
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    24. Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model. Vaccines (Basel). 2024 Apr 04; 12(4). Rivera-Hernandez T, Carnathan DG, Richter J, Marchant P, Cork AJ, Elangovan G, Henningham A, Cole JN, Choudhury B, Moyle PM, Toth I, Batzloff MR, Good MF, Agarwal P, Kapoor N, Nizet V, Silvestri G, Walker MJ. PMID: 38675764; PMCID: PMC11054769.
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    25. A conserved antigen induces respiratory Th17-mediated broad serotype protection against pneumococcal superinfection. Cell Host Microbe. 2024 Mar 13; 32(3):304-314.e8. Liu X, Van Maele L, Matarazzo L, Soulard D, Alves Duarte da Silva V, de Bakker V, Dénéréaz J, Bock FP, Taschner M, Ou J, Gruber S, Nizet V, Sirard JC, Veening JW. PMID: 38417443.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum. Arterioscler Thromb Vasc Biol. 2024 04; 44(4):822-825. Lupieri A, S A Passos L, Levine RA, Nizet V, Aikawa E. PMID: 38357818; PMCID: PMC10978236.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans. ACS Chem Biol. 2024 03 15; 19(3):619-628. Ngo TE, Ecker A, Ryu B, Guild A, Remmel A, Boudreau PD, Alexander KL, Naman CB, Glukhov E, Avalon NE, Shende VV, Thomas L, Dahesh S, Nizet V, Gerwick L, Gerwick WH. PMID: 38330248; PMCID: PMC10949194.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection. bioRxiv. 2024 Feb 05. Mercado-Evans V, Chew C, Serchejian C, Saltzman A, Mejia ME, Zulk JJ, Cornax I, Nizet V, Patras KA. PMID: 38370726; PMCID: PMC10871275.
      View in: PubMed   Mentions:
    29. Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes. Proc Natl Acad Sci U S A. 2024 Feb 06; 121(6):e2300644120. Zhang Y, Bharathi V, Dokoshi T, de Anda J, Ursery LT, Kulkarni NN, Nakamura Y, Chen J, Luo EWC, Wang L, Xu H, Coady A, Zurich R, Lee MW, Matsui T, Lee H, Chan LC, Schepmoes AA, Lipton MS, Zhao R, Adkins JN, Clair GC, Thurlow LR, Schisler JC, Wolfgang MC, Hagan RS, Yeaman MR, Weiss TM, Chen X, Li MMH, Nizet V, Antoniak S, Mackman N, Gallo RL, Wong GCL. PMID: 38306481; PMCID: PMC10861912.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Comparative molecular profiling of multidrug-resistant Pseudomonas aeruginosa identifies novel mutations in regional clinical isolates from South India. JAC Antimicrob Resist. 2024 Feb; 6(1):dlae001. Menon ND, Somanath P, Jossart J, Vijayakumar G, Shetty K, Baswe M, Chatterjee M, Hari MB, Nair S, Kumar VA, Nair BG, Nizet V, Perry JJP, Kumar GB. PMID: 38230352; PMCID: PMC10789591.
      View in: PubMed   Mentions: 1  
    31. Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant Acinetobacter baumannii. mSystems. 2024 Feb 20; 9(2):e0060623. Menon ND, Poudel S, Sastry AV, Rychel K, Szubin R, Dillon N, Tsunemoto H, Hirose Y, Nair BG, Kumar GB, Palsson BO, Nizet V. PMID: 38189271; PMCID: PMC10878099.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. Determining Susceptibility and Potential Mediators of Resistance for the Novel Polymyxin Derivative, SPR206, in Acinetobacter baumannii. Antibiotics (Basel). 2024 Jan 04; 13(1). Abdul-Mutakabbir JC, Opoku NS, Tan KK, Jorth P, Nizet V, Fletcher HM, Kaye KS, Rybak MJ. PMID: 38247606; PMCID: PMC10812597.
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    33. Exploring Roles of the Polysaccharide Capsule in Pathogenesis of Hypervirulent Acinetobacter baumannii Clinical Isolate Lac-4. Antibiotics (Basel). 2023 Dec 20; 13(1). Bjånes E, Koh T, Qayum T, Zurich R, McCabe S, Hampel K, Cartwright L, Nizet V. PMID: 38275320; PMCID: PMC10812722.
      View in: PubMed   Mentions: 1  
    34. The Group A Streptococcal Vaccine Candidate VAX-A1 Protects against Group B Streptococcus Infection via Cross-Reactive IgG Targeting Virulence Factor C5a Peptidase. Vaccines (Basel). 2023 Dec 03; 11(12). McCabe S, Bjånes E, Hendriks A, Wang Z, van Sorge NM, Pill-Pepe L, Bautista L, Chu E, Codée JDC, Fairman J, Kapoor N, Uchiyama S, Nizet V. PMID: 38140215; PMCID: PMC10747066.
      View in: PubMed   Mentions:
    35. Measuring beta-lactam minimum inhibitory concentrations in Staphylococcus aureus in the clinical microbiology laboratory: pinning the tail on the donkey. J Clin Microbiol. 2024 01 17; 62(1):e0036623. Sakoulas G, Nizet V. PMID: 37966224; PMCID: PMC10793257.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. The Parasporal Body of Bacillus thuringiensis subsp. israelensis: A Unique Phage Capsid-Associated Prokaryotic Insecticidal Organelle. Biology (Basel). 2023 Nov 11; 12(11). Rudd SR, Miranda LS, Curtis HR, Bigot Y, Diaz-Mendoza M, Hice R, Nizet V, Park HW, Blaha G, Federici BA, Bideshi DK. PMID: 37998020; PMCID: PMC10669011.
      View in: PubMed   Mentions: 1  
    37. Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia. Proc Natl Acad Sci U S A. 2023 07 25; 120(30):e2301538120. Askarian F, Tsai CM, Cordara G, Zurich RH, Bjånes E, Golten O, Vinther Sørensen H, Kousha A, Meier A, Chikwati E, Bruun JA, Ludviksen JA, Choudhury B, Trieu D, Davis S, Edvardsen PKT, Mollnes TE, Liu GY, Krengel U, Conrad DJ, Vaaje-Kolstad G, Nizet V. PMID: 37459522; PMCID: PMC10372616.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    38. A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity. J Biol Chem. 2023 08; 299(8):104980. Wang KC, Kuliyev E, Nizet V, Ghosh P. PMID: 37390991; PMCID: PMC10400905.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis. Nat Commun. 2023 06 17; 14(1):3603. Mohanty T, Karlsson CAQ, Chao Y, Malmström E, Bratanis E, Grentzmann A, Mørch M, Nizet V, Malmström L, Linder A, Shannon O, Malmström J. PMID: 37330510; PMCID: PMC10276868.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    40. Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins. mSystems. 2023 Jun 29; 8(3):e0024723. Hirose Y, Poudel S, Sastry AV, Rychel K, Lamoureux CR, Szubin R, Zielinski DC, Lim HG, Menon ND, Bergsten H, Uchiyama S, Hanada T, Kawabata S, Palsson BO, Nizet V. PMID: 37278526; PMCID: PMC10308926.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    41. Malice in Chains. J Infect Dis. 2023 05 12; 227(10):1117-1118. Osowicki J, Nizet V. PMID: 36748315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders. Camb Prism Precis Med. 2023; 1:e25. Baglaenko Y, Wagner C, Bhoj VG, Brodin P, Gershwin ME, Graham D, Invernizzi P, Kidd KK, Korsunsky I, Levy M, Mammen AL, Nizet V, Ramirez-Valle F, Stites EC, Williams MS, Wilson M, Rose NR, Ladd V, Sirota M. PMID: 38550937; PMCID: PMC10953750.
      View in: PubMed   Mentions:
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    227. Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9515-20. Stewart CM, Buffalo CZ, Valderrama JA, Henningham A, Cole JN, Nizet V, Ghosh P. PMID: 27512043; PMCID: PMC5003295.
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    228. Conquering Neutrophils. PLoS Pathog. 2016 07; 12(7):e1005682. Döhrmann S, Cole JN, Nizet V. PMID: 27467389; PMCID: PMC4965185.
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    229. Alterations in neonatal neutrophil function attributable to increased immature forms. Early Hum Dev. 2016 12; 103:1-7. Makoni M, Eckert J, Anne Pereira H, Nizet V, Lawrence SM. PMID: 27428466; PMCID: PMC5154866.
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    230. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep. 2016 06 29; 6:28852. Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. PMID: 27352769; PMCID: PMC4926279.
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    231. Component Analysis of Multipurpose Contact Lens Solutions To Enhance Activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother. 2016 07; 60(7):4259-63. Lin L, Kim J, Chen H, Kowalski R, Nizet V. PMID: 27139484; PMCID: PMC4914654.
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    232. Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models. mBio. 2016 06 14; 7(3). Rivera-Hernandez T, Pandey M, Henningham A, Cole J, Choudhury B, Cork AJ, Gillen CM, Ghaffar KA, West NP, Silvestri G, Good MF, Moyle PM, Toth I, Nizet V, Batzloff MR, Walker MJ. PMID: 27302756; PMCID: PMC4916377.
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    233. Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3801-9. Bosi E, Monk JM, Aziz RK, Fondi M, Nizet V, Palsson BØ. PMID: 27286824; PMCID: PMC4932939.
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    234. Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract. Sci Rep. 2016 05 31; 6:26836. Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon MG, Walker MJ, Watson ME, Ulett GC. PMID: 27241677; PMCID: PMC4886215.
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    235. Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus causing bacteremia by human cathelicidin LL-37. Eur J Clin Microbiol Infect Dis. 2016 Sep; 35(9):1441-7. Le J, Dam Q, Schweizer M, Thienphrapa W, Nizet V, Sakoulas G. PMID: 27234592; PMCID: PMC4983239.
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    236. Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep. 2016 07; 36(3). Völlger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schäfer ST, Naim HY, Nizet V, von Köckritz-Blickwede M. PMID: 27129288; PMCID: PMC5293572.
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    237. Molecular dynamic study of MlaC protein in Gram-negative bacteria: conformational flexibility, solvent effect and protein-phospholipid binding. Protein Sci. 2016 08; 25(8):1430-7. Huang YM, Miao Y, Munguia J, Lin L, Nizet V, McCammon JA. PMID: 27111825; PMCID: PMC4972199.
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    238. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-13973. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJP, Nizet V. PMID: 27226531; PMCID: PMC4933157.
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    239. Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host. Front Microbiol. 2016; 7:402. von Köckritz-Blickwede M, Blodkamp S, Nizet V. PMID: 27064864; PMCID: PMC4811905.
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    241. Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia. J Antimicrob Chemother. 2016 May; 71(5):1264-9. Kumaraswamy M, Lin L, Olson J, Sun CF, Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amaro D, Rohde M, Pogliano J, Sakoulas G, Nizet V. PMID: 26832758; PMCID: PMC4830416.
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    242. Bacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus. EBioMedicine. 2016 Feb; 4:95-103. Quach DT, Sakoulas G, Nizet V, Pogliano J, Pogliano K. PMID: 26981574; PMCID: PMC4776060.
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    243. Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan. Cell Host Microbe. 2015 Dec 09; 18(6):694-704. Kolar SL, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. PMID: 26651945; PMCID: PMC4683412.
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    244. Streptococcal toxins: role in pathogenesis and disease. Cell Microbiol. 2015 Dec; 17(12):1721-41. Barnett TC, Cole JN, Rivera-Hernandez T, Henningham A, Paton JC, Nizet V, Walker MJ. PMID: 26433203.
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    245. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015; 6:581. Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V. PMID: 26635795; PMCID: PMC4644796.
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    246. Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for β-Lactam-Daptomycin Synergy. Antimicrob Agents Chemother. 2016 01; 60(1):451-8. Berti AD, Theisen E, Sauer JD, Nonejuie P, Olson J, Pogliano J, Sakoulas G, Nizet V, Proctor RA, Rose WE. PMID: 26525797; PMCID: PMC4704217.
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    247. Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing. Cell Host Microbe. 2015 Oct 14; 18(4):471-7. LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. PMID: 26468750; PMCID: PMC4636435.
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    248. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015 Oct 13; 6:8369. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V. PMID: 26458291; PMCID: PMC4610010.
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    249. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J. 2015 Nov 12; 34(22):2775-88. Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. PMID: 26459514; PMCID: PMC4682649.
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    250. Inflammasome/IL-1β Responses to Streptococcal Pathogens. Front Immunol. 2015; 6:518. LaRock CN, Nizet V. PMID: 26500655; PMCID: PMC4597127.
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    251. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. J Mol Med (Berl). 2016 Feb; 94(2):219-33. Secundino I, Lizcano A, Roupé KM, Wang X, Cole JN, Olson J, Ali SR, Dahesh S, Amayreh LK, Henningham A, Varki A, Nizet V. PMID: 26411873; PMCID: PMC4766071.
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    252. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. PMID: 26391660; PMCID: PMC4586747.
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    253. Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PLoS One. 2015; 10(8):e0136605. Pence MA, Haste NM, Meharena HS, Olson J, Gallo RL, Nizet V, Kristian SA. PMID: 26305782; PMCID: PMC4549145.
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    254. Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics. Antimicrob Agents Chemother. 2015 Oct; 59(10):6132-9. Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V. PMID: 26195528; PMCID: PMC4576044.
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    255. Stopping superbugs, maintaining the microbiota. Sci Transl Med. 2015 Jul 08; 7(295):295ed8. Nizet V. PMID: 26157027.
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    256. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. PMID: 26150541; PMCID: PMC4534644.
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    257. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chem Biol. 2015 Jun 18; 22(6):785-92. Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. PMID: 26091171; PMCID: PMC4475277.
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    258. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. EBioMedicine. 2015 Jul; 2(7):690-8. Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V. PMID: 26288841; PMCID: PMC4534682.
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    259. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS. PMID: 25930739; PMCID: PMC4545249.
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    260. In vitro activity of daptomycin in combination with β-lactams, gentamicin, rifampin, and tigecycline against daptomycin-nonsusceptible enterococci. Antimicrob Agents Chemother. 2015 Jul; 59(7):4279-88. Hindler JA, Wong-Beringer A, Charlton CL, Miller SA, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R. PMID: 25963982; PMCID: PMC4468720.
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    261. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med (Berl). 2015 Jun; 93(6):619-31. Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. PMID: 25940316; PMCID: PMC4469262.
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    262. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr; 11(4):e1004818. Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. PMID: 25927232; PMCID: PMC4415805.
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    263. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE. PMID: 25824841; PMCID: PMC4432760.
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    264. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4453-8. Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. PMID: 25831516; PMCID: PMC4394260.
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    265. A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response. mBio. 2015 Mar 10; 6(2):e00133. Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V. PMID: 25759502; PMCID: PMC4453525.
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    266. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α. Immunity. 2015 Mar 17; 42(3):484-98. Shalova IN, Lim JY, Chittezhath M, Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano V, Cubillos-Zapata C, Rapisarda A, Chen J, Duan K, Yang H, Poidinger M, Melillo G, Nizet V, Arnalich F, López-Collazo E, Biswas SK. PMID: 25746953.
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    267. Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics. Antimicrob Agents Chemother. 2015 May; 59(5):2799-806. Berti AD, Baines SL, Howden BP, Sakoulas G, Nizet V, Proctor RA, Rose WE. PMID: 25733508; PMCID: PMC4394801.
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    269. Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens. Biochim Biophys Acta. 2015 Nov; 1848(11 Pt B):3047-54. LaRock CN, Nizet V. PMID: 25701232; PMCID: PMC4539303.
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    270. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. Bier E, Nizet V. PMID: 25674980.
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    273. Examining the use of ceftaroline in the treatment of Streptococcus pneumoniae meningitis with reference to human cathelicidin LL-37. Antimicrob Agents Chemother. 2015 Apr; 59(4):2428-31. Sakoulas G, Nonejuie P, Kullar R, Pogliano J, Rybak MJ, Nizet V. PMID: 25605351; PMCID: PMC4356754.
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    274. Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. Mol Cell. 2015 Jan 08; 57(1):55-68. Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M. PMID: 25544559; PMCID: PMC4373083.
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    275. Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability. Eur J Med Chem. 2015 Jan 27; 90:448-61. Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB. PMID: 25461893; PMCID: PMC4291291.
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    277. The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps. Biochem J. 2014 Nov 15; 464(1):3-11. Neumann A, Berends ET, Nerlich A, Molhoek EM, Gallo RL, Meerloo T, Nizet V, Naim HY, von Köckritz-Blickwede M. PMID: 25181554.
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    279. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem. 2014 Nov 14; 289(46):32303-32315. Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. PMID: 25266727; PMCID: PMC4231703.
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    280. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep; 12(9):624-34. Guichard A, Nizet V, Bier E. PMID: 25118884; PMCID: PMC4274738.
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    288. Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases. Infect Dis Ther. 2014 Dec; 3(2):159-74. Bhandari T, Nizet V. PMID: 25134687; PMCID: PMC4269623.
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