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Victor Nizet

Title(s)Distinguished Professor, Pediatrics
SchoolHealth Sciences
Phone858-534-7408
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    Other Positions
    Title(s)Distinguished Professor, School of Pharmacy and Pharmaceutical Science


    Collapse Biography 
    Collapse Education and Training
    Reed College, Portland, ORBA05/1984Biology
    Stanford University, Stanford, CAMD05/1989Medicine
    Collapse Awards and Honors
    2019NIH/NAID Merit Award (R37)
    2017UCSD Chancellor's Associates Award for Excellence in Research in Science & Engineering
    2013UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring
    2013Rady Children’s Hospital Award for Excellence in Research
    2012Elected to Fellowship in the American Academy of Microbiology
    2010Elected to Membership in the Association of American Physicians
    2008E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
    2008Stephen Silberstein Senior Fellow of the American Asthma Foundation
    2006Elected to Membership in the American Society for Clinical Investigation
    2006Elected to the American Pediatric Society
    2004Career Investigator Award, American Lung Association
    2004Established Investigator Award, American Heart Association
    2002Named the 39th Mallinckrodt Scholar by the Edward Mallinckrodt, Jr. Foundation
    2002Pediatric Infectious Diseases Society Young Investigator Award
    2002Elected to the Society for Pediatric Research
    2001UCSD Department of Pediatrics Commitment to Resident Education Award
    2000UCSD Department of Pediatrics Outstanding Faculty Teacher of the Year
    1993Sidney Farber Outstanding Houseofficer Award, Children’s Hospital, Boston
    1984Class of 1922 Award, Reed College, “Most Outstanding Senior Thesis”
    1984Phi Beta Kappa, Reed College

    Collapse Overview 
    Collapse Overview
    Victor Nizet is a Distinguished Professor and Vice Chair for Basic Research and Chief of the Division of Host-Microbe Systems & Therapeutics at the University of California, San Diego (UCSD), School of Medicine and Distinguished Professor at UCSD Skaggs School of Pharmacy & Pharmaceutical Sciences. Dr. Nizet is a graduate of Reed College, received his medical training at Stanford University School of Medicine, completed a Residency and Chief Residency in Pediatrics at Harvard University's Children's Hospital in Boston, Massachusetts, and a then a Fellowship in Pediatric Infectious Diseases at the University of Washington’s Children's Hospital in Seattle. Dr. Nizet is Faculty Lead for the UCSD Collaborative to Halt Antibiotic-Resistant Microbes (CHARM), a multidisciplinary research and educational program that debuted in Fall 2019. Dr. Nizet has authored over 440 peer-reviewed publications and has collaborated with several biotechnology interests in developing new antibiotic and immune-based therapies against drug-resistant pathogens. Details of his research program can be found on the laboratory website: http://nizetlab.ucsd.edu
    Collapse Interests

    Collapse Research 
    Collapse Research Activities and Funding
    Glycan-Lectin Receptor Regulation of Macrophage Maturation and Lung Innate Defenses in the Fetus and Newborn Infant
    NIH/NIAID R01AI142864Jul 17, 2019 - Jun 30, 2022
    Role: Co-Principal Investigator
    C3-Dependent Intracellular Killing in Innate Immunity and Bacterial Pathogenesis
    NIH/NIAID R01AI145325Mar 5, 2019 - Feb 29, 2024
    Role: Co-Principal Investigator
    2018 Streptococcal Biology Gordon Research Conference
    NIH/NIAID R13AI140636Jul 1, 2018 - Jun 30, 2019
    Role: Principal Investigator
    Broad recognition of group A Streptococcus M proteins
    NIH/NIAID R21AI140436May 18, 2018 - Apr 30, 2020
    Role: Co-Principal Investigator
    Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
    NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Glycoprotein Remodeling in the Vasculopathy and Coagulopathy of Sepsis
    NIH/NHLBI R01HL125352Sep 15, 2014 - May 31, 2019
    Role: Principal Investigator
    Analyzing a novel mechanism of action of bacterial cAMP producing toxins
    NIH/NIAID R01AI110713Feb 1, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH/NIAID R56AI096837Jul 1, 2011 - Jul 31, 2019
    Role: Co-Principal Investigator
    Glycan Modulation of Inflammatory Responses
    NIH P01HL107150Jul 1, 2011 - May 31, 2018
    Role: Co-Investigator
    Mechanisms of the M protein in group A Streptococcus virulence
    NIH/NIAID R01AI096837Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
    NIH/NIAID R01AI093451Apr 5, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
    NIH/NIAID R56AI090863Aug 2, 2010 - Jul 31, 2011
    Role: Principal Investigator
    GAS Switch from Colonizing Bacterium to Invasive Pathogen
    NIH/NIAID R01AI077780Sep 1, 2008 - Jan 31, 2020
    Role: Principal Investigator
    Sialic Acid O-Acetylation in GBS Pathogenesis &Immunity
    NIH/NICHD R01HD051796Apr 7, 2006 - Feb 28, 2012
    Role: Principal Investigator
    Molecular Analyses and Interventions for Biodefense and Emerging Pathogens
    NIH U54AI057153Sep 4, 2003 - Feb 28, 2014
    Role: Co-Investigator
    Cathelicidin in Skin Immunity
    NIH/NIAID R01AI052453Sep 15, 2002 - Feb 29, 2024
    Role: Principal Investigator
    SLS: Molecular Basis and Role in Invasive GAS Disease
    NIH/NIAID R01AI048694Apr 1, 2002 - Mar 31, 2007
    Role: Principal Investigator
    PENETRATION OF THE BLOOD BRAIN BARRIER IN GBS MENINGITIS
    NIH/NICHD R03HD037224Feb 1, 1999 - Aug 31, 2001
    Role: Principal Investigator
    MOLECULAR BASIS OF LUNG INJURY IN GBS PNEUMONIA
    NIH/NIAID K08AI001451Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nerlich A, Lapschies AM, Kohler TP, Cornax I, Eichhorn I, Goldmann O, Krienke P, Bergmann S, Nizet V, Hammerschmidt S, Rohde M, Fulde M. Homophilic protein interactions facilitate bacterial aggregation and IgG-dependent complex formation by the Streptococcus canis M protein SCM. Virulence. 2019 12; 10(1):194-206. PMID: 30829556.
      View in: PubMed
    2. Sakoulas G, Geriak M, Haddad F, Rose W, LaPlante K, Zervos M, Kullar R, Nizet V. Reply to Kalil et al., "Is Daptomycin plus Ceftaroline Associated with Better Clinical Outcomes than Standard of Care Monotherapy for Staphylococcus aureus Bacteremia?" Antimicrob Agents Chemother. 2019 Nov; 63(11). PMID: 31640978.
      View in: PubMed
    3. Machado H, Weng LL, Dillon N, Seif Y, Holland M, Pekar JE, Monk JM, Nizet V, Palsson BO, Feist AM. Strain-Specific Metabolic Requirements Revealed by a Defined Minimal Medium for Systems Analyses of Staphylococcus aureus. Appl Environ Microbiol. 2019 Nov 01; 85(21). PMID: 31471305.
      View in: PubMed
    4. Toledo AG, Golden G, Campos AR, Cuello H, Sorrentino J, Lewis N, Varki N, Nizet V, Smith JW, Esko JD. Proteomic atlas of organ vasculopathies triggered by Staphylococcus aureus sepsis. Nat Commun. 2019 Oct 11; 10(1):4656. PMID: 31604940.
      View in: PubMed
    5. Walker MJ, Brouwer S, Forde BM, Worthing KA, McIntyre L, Sundac L, Maloney S, Roberts LW, Barnett TC, Richter J, Cork AJ, Irwin AD, You Y, Zhang J, Dougan G, Yuen KY, Nizet V, Beatson SA, Grimwood K, Davies MR. Detection of Epidemic Scarlet Fever Group A Streptococcus in Australia. Clin Infect Dis. 2019 Sep 13; 69(7):1232-1234. PMID: 30721938.
      View in: PubMed
    6. Gao NJ, Al-Bassam MM, Poudel S, Wozniak JM, Gonzalez DJ, Olson J, Zengler K, Nizet V, Valderrama JA. Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease. Front Microbiol. 2019; 10:1967. PMID: 31507572.
      View in: PubMed
    7. Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. Elife. 2019 08 13; 8. PMID: 31408005.
      View in: PubMed
    8. Volk CF, Burgdorf S, Edwardson G, Nizet V, Sakoulas G, Rose WE. IL-1ß and IL-10 Host Responses in Patients with Staphylococcus aureus Bacteremia Determined by Antimicrobial Therapy. Clin Infect Dis. 2019 Aug 01. PMID: 31365924.
      View in: PubMed
    9. Dillon N, Holland M, Tsunemoto H, Hancock B, Cornax I, Pogliano J, Sakoulas G, Nizet V. Surprising synergy of dual translation inhibition vs. Acinetobacter baumannii and other multidrug-resistant bacterial pathogens. EBioMedicine. 2019 Aug; 46:193-201. PMID: 31353294.
      View in: PubMed
    10. LaRock DL, Sands JS, Ettouati E, Richard M, Bushway PJ, Adler ED, Nizet V, LaRock CN. Inflammasome inhibition blocks cardiac glycoside cell toxicity. J Biol Chem. 2019 Aug 23; 294(34):12846-12854. PMID: 31300552.
      View in: PubMed
    11. Ulloa ER, Dillon N, Tsunemoto H, Pogliano J, Sakoulas G, Nizet V. Avibactam Sensitizes Carbapenem-Resistant NDM-1-Producing Klebsiella pneumoniae to Innate Immune Clearance. J Infect Dis. 2019 Jul 02; 220(3):484-493. PMID: 30923801.
      View in: PubMed
    12. Dahesh S, Wong B, Nizet V, Sakoulas G, Tran TT, Aitken SL. Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin. Antimicrob Agents Chemother. 2019 Jul; 63(7). PMID: 31235559.
      View in: PubMed
    13. Patras KA, Ha AD, Rooholfada E, Olson J, Ramachandra Rao SP, Lin AE, Nizet V. Augmentation of Urinary Lactoferrin Enhances Host Innate Immune Clearance of Uropathogenic Escherichia coli. J Innate Immun. 2019; 11(6):481-495. PMID: 31055580.
      View in: PubMed
    14. Rivera-Hernandez T, Carnathan DG, Jones S, Cork AJ, Davies MR, Moyle PM, Toth I, Batzloff MR, McCarthy J, Nizet V, Goldblatt D, Silvestri G, Walker MJ. An Experimental Group A Streptococcus Vaccine That Reduces Pharyngitis and Tonsillitis in a Nonhuman Primate Model. MBio. 2019 04 30; 10(2). PMID: 31040243.
      View in: PubMed
    15. Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Pogliano J, Knight R, Nizet V, Palsson BO, Feist AM. Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media. Sci Data. 2019 04 26; 6(1):43. PMID: 31028276.
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    16. Geriak M, Haddad F, Rizvi K, Rose W, Kullar R, LaPlante K, Yu M, Vasina L, Ouellette K, Zervos M, Nizet V, Sakoulas G. Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2019 May; 63(5). PMID: 30858203.
      View in: PubMed
    17. Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion. Front Pharmacol. 2019; 10:323. PMID: 31024300.
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    18. Zhang Q, Chao TC, Patil VS, Qin Y, Tiwari SK, Chiou J, Dobin A, Tsai CM, Li Z, Dang J, Gupta S, Urdahl K, Nizet V, Gingeras TR, Gaulton KJ, Rana TM. The long noncoding RNA ROCKI regulates inflammatory gene expression. EMBO J. 2019 Apr 15; 38(8). PMID: 30918008.
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    19. Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V. Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing. Proc Natl Acad Sci U S A. 2019 04 09; 116(15):7465-7470. PMID: 30910970.
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    20. Caffrey AR, Timbrook TT, Ali SR, Nizet V, Sakoulas G. Proton-pump inhibitors do not influence clinical outcomes in patients with Staphylococcus aureus bacteremia. Therap Adv Gastroenterol. 2019; 12:1756284819834273. PMID: 30923573.
      View in: PubMed
    21. Bauman KD, Li J, Murata K, Mantovani SM, Dahesh S, Nizet V, Luhavaya H, Moore BS. Refactoring the Cryptic Streptophenazine Biosynthetic Gene Cluster Unites Phenazine, Polyketide, and Nonribosomal Peptide Biochemistry. Cell Chem Biol. 2019 May 16; 26(5):724-736.e7. PMID: 30853419.
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    22. Meier A, Nizet V. Impact of Anesthetics on Human Neutrophil Function. Anesth Analg. 2019 Mar; 128(3):569-574. PMID: 30507837.
      View in: PubMed
    23. Huang YM, Munguia J, Miao Y, Nizet V, McCammon JA. Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria. Chem Biol Drug Des. 2019 Apr; 93(4):647-652. PMID: 30570806.
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    24. Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Sci Transl Med. 2019 02 06; 11(478). PMID: 30728285.
      View in: PubMed
    25. Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ. 2019 Mar; 26(3):395-408. PMID: 30622307.
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    26. Sakoulas G, Geriak M, Nizet V. Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of ß-Lactam Antibiotics? Clin Infect Dis. 2019 01 01; 68(1):157-164. PMID: 29986019.
      View in: PubMed
    27. Escajadillo T, Nizet V. Pharmacological Targeting of Pore-Forming Toxins as Adjunctive Therapy for Invasive Bacterial Infection. Toxins (Basel). 2018 12 17; 10(12). PMID: 30562923.
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    28. Vrbanac A, Riestra AM, Coady A, Knight R, Nizet V, Patras KA. The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus. BMC Microbiol. 2018 11 26; 18(1):197. PMID: 30477439.
      View in: PubMed
    29. Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection". Antimicrob Agents Chemother. 2018 12; 62(12). PMID: 30478181.
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    30. Coady A, Ramos AR, Olson J, Nizet V, Patras KA. Tamm-Horsfall Protein Protects the Urinary Tract against Candida albicans. Infect Immun. 2018 12; 86(12). PMID: 30297523.
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    31. Uchiyama S, Dahesh S, Nizet V, Kessler J. Enhanced topical delivery of non-complexed molecular iodine for Methicillin-resistant Staphylococcus aureus decolonization. Int J Pharm. 2019 Jan 10; 554:81-86. PMID: 30395958.
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    32. Riestra AM, Valderrama JA, Patras KA, Booth SD, Quek XY, Tsai CM, Nizet V. Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. J Innate Immun. 2019; 11(1):86-98. PMID: 30391945.
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    33. Kavvas ES, Catoiu E, Mih N, Yurkovich JT, Seif Y, Dillon N, Heckmann D, Anand A, Yang L, Nizet V, Monk JM, Palsson BO. Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. Nat Commun. 2018 10 17; 9(1):4306. PMID: 30333483.
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    34. van Hensbergen VP, Movert E, de Maat V, Lüchtenborg C, Le Breton Y, Lambeau G, Payré C, Henningham A, Nizet V, van Strijp JAG, Brügger B, Carlsson F, McIver KS, van Sorge NM. Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects. PLoS Pathog. 2018 10; 14(10):e1007348. PMID: 30321240.
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    35. Yang WH, Heithoff DM, Aziz PV, Haslund-Gourley B, Westman JS, Narisawa S, Pinkerton AB, Millán JL, Nizet V, Mahan MJ, Marth JD. Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis. Cell Host Microbe. 2018 10 10; 24(4):500-513.e5. PMID: 30308156.
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    36. Patras KA, Derieux J, Al-Bassam MM, Adiletta N, Vrbanac A, Lapek JD, Zengler K, Gonzalez DJ, Nizet V. Group B Streptococcus Biofilm Regulatory Protein A Contributes to Bacterial Physiology and Innate Immune Resistance. J Infect Dis. 2018 10 05; 218(10):1641-1652. PMID: 29868829.
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    37. Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD. Siglec-7 engagement by GBS ß-protein suppresses pyroptotic cell death of natural killer cells. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):10410-10415. PMID: 30254166.
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    38. Askarian F, Wagner T, Johannessen M, Nizet V. Staphylococcus aureus modulation of innate immune responses through Toll-like (TLR), (NOD)-like (NLR) and C-type lectin (CLR) receptors. FEMS Microbiol Rev. 2018 09 01; 42(5):656-671. PMID: 29893825.
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    39. Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A. Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. PLoS Pathog. 2018 06; 14(6):e1007133. PMID: 29912959.
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    40. Gupta N, Liu R, Shin S, Sinha R, Pogliano J, Pogliano K, Griffin JH, Nizet V, Corriden R. SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity. J Antimicrob Chemother. 2018 06 01; 73(6):1586-1594. PMID: 29514266.
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    41. Kumaraswamy M, Collignon S, Do C, Kim J, Nizet V, Friend J. Decontaminating surfaces with atomized disinfectants generated by a novel thickness-mode lithium niobate device. Appl Microbiol Biotechnol. 2018 Aug; 102(15):6459-6467. PMID: 29804135.
      View in: PubMed
    42. Soderholm AT, Barnett TC, Korn O, Rivera-Hernandez T, Seymour LM, Schulz BL, Nizet V, Wells CA, Sweet MJ, Walker MJ. Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP. Front Cell Infect Microbiol. 2018; 8:160. PMID: 29868516.
      View in: PubMed
    43. Gupta N, Nizet V. Stabilization of Hypoxia-Inducible Factor-1 Alpha Augments the Therapeutic Capacity of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Pneumonia. Front Med (Lausanne). 2018; 5:131. PMID: 29780805.
      View in: PubMed
    44. van den Broek MFL, De Boeck I, Claes IJJ, Nizet V, Lebeer S. Multifactorial inhibition of lactobacilli against the respiratory tract pathogen Moraxella catarrhalis. Benef Microbes. 2018 Apr 25; 9(3):429-439. PMID: 29633637.
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    45. Jati S, Kundu S, Chakraborty A, Mahata SK, Nizet V, Sen M. Wnt5A Signaling Promotes Defense Against Bacterial Pathogens by Activating a Host Autophagy Circuit. Front Immunol. 2018; 9:679. PMID: 29686674.
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    46. Monogue ML, Sakoulas G, Nizet V, Nicolau DP. Humanized Exposures of a ß-Lactam-ß-Lactamase Inhibitor, Tazobactam, versus Non-ß-Lactam-ß-Lactamase Inhibitor, Avibactam, with or without Colistin, against Acinetobacter baumannii in Murine Thigh and Lung Infection Models. Pharmacology. 2018; 101(5-6):255-261. PMID: 29533955.
      View in: PubMed
    47. Britt NS, Tirmizi S, Ritchie DJ, Topal JE, McManus D, Nizet V, Casabar E, Sakoulas G. Telavancin for refractory MRSA bacteraemia in intermittent haemodialysis recipients. J Antimicrob Chemother. 2018 03 01; 73(3):764-767. PMID: 29244141.
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    48. Patras KA, Nizet V. Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches. Front Pediatr. 2018; 6:27. PMID: 29520354.
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    49. Haripriyan J, Omanakuttan A, Menon ND, Vanuopadath M, Nair SS, Corriden R, Nair BG, Nizet V, Kumar GB. Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa. Sci Rep. 2018 02 21; 8(1):3437. PMID: 29467483.
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    50. Askarian F, Lapek JD, Dongre M, Tsai CM, Kumaraswamy M, Kousha A, Valderrama JA, Ludviksen JA, Cavanagh JP, Uchiyama S, Mollnes TE, Gonzalez DJ, Wai SN, Nizet V, Johannessen M. Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models. Front Microbiol. 2018; 9:262. PMID: 29515544.
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    51. Gupta N, Sinha R, Krasnodembskaya A, Xu X, Nizet V, Matthay MA, Griffin JH. The TLR4-PAR1 Axis Regulates Bone Marrow Mesenchymal Stromal Cell Survival and Therapeutic Capacity in Experimental Bacterial Pneumonia. Stem Cells. 2018 05; 36(5):796-806. PMID: 29396891.
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    52. Chen Y, Chen M, Zhang Y, Lee JH, Escajadillo T, Gong H, Fang RH, Gao W, Nizet V, Zhang L. Broad-Spectrum Neutralization of Pore-Forming Toxins with Human Erythrocyte Membrane-Coated Nanosponges. Adv Healthc Mater. 2018 07; 7(13):e1701366. PMID: 29436150.
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    53. Lawrence SM, Corriden R, Nizet V. The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis. Microbiol Mol Biol Rev. 2018 06; 82(1). PMID: 29436479.
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    54. Choe D, Szubin R, Dahesh S, Cho S, Nizet V, Palsson B, Cho BK. Genome-scale analysis of Methicillin-resistant Staphylococcus aureus USA300 reveals a tradeoff between pathogenesis and drug resistance. Sci Rep. 2018 02 02; 8(1):2215. PMID: 29396540.
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    55. Henningham A, Davies MR, Uchiyama S, van Sorge NM, Lund S, Chen KT, Walker MJ, Cole JN, Nizet V. Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wall Carbohydrate Antigen in Non-M1-Serotype Group A Streptococcus. MBio. 2018 01 30; 9(1). PMID: 29382733.
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    56. Liu JZ, Ali SR, Bier E, Nizet V. Innate Immune Interactions between Bacillus anthracis and Host Neutrophils. Front Cell Infect Microbiol. 2018; 8:2. PMID: 29404280.
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    57. Kumaraswamy M, Do C, Sakoulas G, Nonejuie P, Tseng GW, King H, Fierer J, Pogliano J, Nizet V. Listeria monocytogenes endocarditis: case report, review of the literature, and laboratory evaluation of potential novel antibiotic synergies. Int J Antimicrob Agents. 2018 Mar; 51(3):468-478. PMID: 29337066.
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    58. Andreoni F, Ugolini F, Keller N, Neff A, Nizet V, Hollands A, Marques Maggio E, Zinkernagel AS, Schuepbach RA. Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis. J Infect Dis. 2018 01 04; 217(2):270-279. PMID: 29099935.
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    59. Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR. Modeling neuro-immune interactions during Zika virus infection. Hum Mol Genet. 2018 01 01; 27(1):41-52. PMID: 29048558.
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    60. Yang WH, Heithoff DM, Aziz PV, Sperandio M, Nizet V, Mahan MJ, Marth JD. Recurrent infection progressively disables host protection against intestinal inflammation. Science. 2017 12 22; 358(6370). PMID: 29269445.
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    61. Catteau L, Reichmann NT, Olson J, Pinho MG, Nizet V, Van Bambeke F, Quetin-Leclercq J. Synergy between Ursolic and Oleanolic Acids from Vitellaria paradoxa Leaf Extract and ß-Lactams against Methicillin-Resistant Staphylococcus aureus: In Vitro and In Vivo Activity and Underlying Mechanisms. Molecules. 2017 Dec 16; 22(12). PMID: 29258194.
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    62. Valderrama JA, Nizet V. Group A Streptococcus encounters with host macrophages. Future Microbiol. 2018 01; 13:119-134. PMID: 29226710.
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    91. Askarian F, Uchiyama S, Valderrama JA, Ajayi C, Sollid JUE, van Sorge NM, Nizet V, van Strijp JAG, Johannessen M. Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood. Infect Immun. 2017 Jan; 85(1). PMID: 27795358.
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    93. Flores R, Döhrmann S, Schaal C, Hakkim A, Nizet V, Corriden R. The Selective Estrogen Receptor Modulator Raloxifene Inhibits Neutrophil Extracellular Trap Formation. Front Immunol. 2016; 7:566. PMID: 28003814.
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    94. Coady A, Nizet V. SAMP-ending down sepsis. Ann Transl Med. 2016 Dec; 4(24):509. PMID: 28149871.
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    96. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2016 Sep 05; 1(11):16155. PMID: 27595425.
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    110. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-73. PMID: 27226531.
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    115. Kolar SL, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan. Cell Host Microbe. 2015 Dec 09; 18(6):694-704. PMID: 26651945.
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    117. Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015; 6:581. PMID: 26635795.
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    118. Berti AD, Theisen E, Sauer JD, Nonejuie P, Olson J, Pogliano J, Sakoulas G, Nizet V, Proctor RA, Rose WE. Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for ß-Lactam-Daptomycin Synergy. Antimicrob Agents Chemother. 2016 01; 60(1):451-8. PMID: 26525797.
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    121. Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J. 2015 Nov 12; 34(22):2775-88. PMID: 26459514.
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    124. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. PMID: 26391660.
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    126. Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V. Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics. Antimicrob Agents Chemother. 2015 Oct; 59(10):6132-9. PMID: 26195528.
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    129. Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chem Biol. 2015 Jun 18; 22(6):785-92. PMID: 26091171.
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    133. Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med (Berl). 2015 Jun; 93(6):619-31. PMID: 25940316.
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    136. Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4453-8. PMID: 25831516.
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    138. Shalova IN, Lim JY, Chittezhath M, Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano V, Cubillos-Zapata C, Rapisarda A, Chen J, Duan K, Yang H, Poidinger M, Melillo G, Nizet V, Arnalich F, López-Collazo E, Biswas SK. Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1a. Immunity. 2015 Mar 17; 42(3):484-98. PMID: 25746953.
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    140. Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E, Peyssonnaux C. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015 Apr 01; 194(7):3259-66. PMID: 25710915.
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    142. Bier E, Nizet V. Hedgehog: linking uracil to innate defense. Cell Host Microbe. 2015 Feb 11; 17(2):146-8. PMID: 25674980.
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    144. Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA, Nigam S, King CC, Nizet V, Nigam V. The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-?B signaling, and inflammatory gene expression in human aortic valve cells. FASEB J. 2015 May; 29(5):1859-68. PMID: 25630970.
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    150. Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity. 2014 Oct 16; 41(4):518-28. PMID: 25367569.
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    151. Henningham A, Yamaguchi M, Aziz RK, Kuipers K, Buffalo CZ, Dahesh S, Choudhury B, Van Vleet J, Yamaguchi Y, Seymour LM, Ben Zakour NL, He L, Smith HV, Grimwood K, Beatson SA, Ghosh P, Walker MJ, Nizet V, Cole JN. Mutual exclusivity of hyaluronan and hyaluronidase in invasive group A Streptococcus. J Biol Chem. 2014 Nov 14; 289(46):32303-15. PMID: 25266727.
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    152. Guichard A, Nizet V, Bier E. RAB11-mediated trafficking in host-pathogen interactions. Nat Rev Microbiol. 2014 Sep; 12(9):624-34. PMID: 25118884.
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    153. Vega VL, Crotty Alexander LE, Charles W, Hwang JH, Nizet V, De Maio A. Activation of the stress response in macrophages alters the M1/M2 balance by enhancing bacterial killing and IL-10 expression. J Mol Med (Berl). 2014 Dec; 92(12):1305-17. PMID: 25163764.
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    155. Fair RJ, McCoy LS, Hensler ME, Aguilar B, Nizet V, Tor Y. Singly modified amikacin and tobramycin derivatives show increased rRNA A-site binding and higher potency against resistant bacteria. ChemMedChem. 2014 Sep; 9(9):2164-71. PMID: 25055981.
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    156. Döhrmann S, Anik S, Olson J, Anderson EL, Etesami N, No H, Snipper J, Nizet V, Okumura CY. Role for streptococcal collagen-like protein 1 in M1T1 group A Streptococcus resistance to neutrophil extracellular traps. Infect Immun. 2014 Oct; 82(10):4011-20. PMID: 25024366.
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    157. Sakoulas G, Moise PA, Casapao AM, Nonejuie P, Olson J, Okumura CY, Rybak MJ, Kullar R, Dhand A, Rose WE, Goff DA, Bressler AM, Lee Y, Pogliano J, Johns S, Kaatz GW, Ebright JR, Nizet V. Antimicrobial salvage therapy for persistent staphylococcal bacteremia using daptomycin plus ceftaroline. Clin Ther. 2014 Oct 01; 36(10):1317-33. PMID: 25017183.
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    158. Neumann A, Völlger L, Berends ET, Molhoek EM, Stapels DA, Midon M, Friães A, Pingoud A, Rooijakkers SH, Gallo RL, Mörgelin M, Nizet V, Naim HY, von Köckritz-Blickwede M. Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases. J Innate Immun. 2014; 6(6):860-8. PMID: 25012862.
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    159. Chang YC, Nizet V. The interplay between Siglecs and sialylated pathogens. Glycobiology. 2014 Sep; 24(9):818-25. PMID: 24996821.
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    160. Bhandari T, Nizet V. Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases. Infect Dis Ther. 2014 Dec; 3(2):159-74. PMID: 25134687.
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    162. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. PMID: 24922575.
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    163. Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. 2014 Jun 02; 211(6):1231-42. PMID: 24799499.
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    164. Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V. Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med (Berl). 2014 Sep; 92(9):951-9. PMID: 24788876.
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    165. Liu Y, Haste NM, Thienphrapa W, Li J, Nizet V, Hensler M, Li R. Marinopyrrole derivatives as potential antibiotic agents against methicillin-resistant Staphylococcus aureus (III). Mar Drugs. 2014 Apr 30; 12(5):2458-70. PMID: 24796304.
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    166. Hensler ME, Jang KH, Thienphrapa W, Vuong L, Tran DN, Soubih E, Lin L, Haste NM, Cunningham ML, Kwan BP, Shaw KJ, Fenical W, Nizet V. Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2014 Aug; 67(8):549-53. PMID: 24736856.
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    167. Walker MJ, Barnett TC, McArthur JD, Cole JN, Gillen CM, Henningham A, Sriprakash KS, Sanderson-Smith ML, Nizet V. Disease manifestations and pathogenic mechanisms of Group A Streptococcus. Clin Microbiol Rev. 2014 Apr; 27(2):264-301. PMID: 24696436.
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    168. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5520-5. PMID: 24706917.
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    169. Sakoulas G, Guram K, Reyes K, Nizet V, Zervos M. Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting. J Clin Microbiol. 2014 Jun; 52(6):2172-4. PMID: 24648548.
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    170. Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon JE, Dorrestein PC, Nizet V. Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics. 2014 May; 13(5):1262-72. PMID: 24567418.
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    171. Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK. Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-?. PLoS One. 2014; 9(2):e89284. PMID: 24586659.
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    172. Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. PLoS One. 2014; 9(2):e89274. PMID: 24586650.
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    173. Fine AM, Nizet V, Mandl KD. Participatory medicine: a home score for streptococcal pharyngitis. Ann Intern Med. 2014 Feb 18; 160(4):289. PMID: 24534928.
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    174. Randis TM, Gelber SE, Hooven TA, Abellar RG, Akabas LH, Lewis EL, Walker LB, Byland LM, Nizet V, Ratner AJ. Group B Streptococcus ß-hemolysin/cytolysin breaches maternal-fetal barriers to cause preterm birth and intrauterine fetal demise in vivo. J Infect Dis. 2014 Jul 15; 210(2):265-73. PMID: 24474814.
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    175. Askarian F, van Sorge NM, Sangvik M, Beasley FC, Henriksen JR, Sollid JU, van Strijp JA, Nizet V, Johannessen M. A Staphylococcus aureus TIR domain protein virulence factor blocks TLR2-mediated NF-?B signaling. J Innate Immun. 2014; 6(4):485-98. PMID: 24481289.
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    176. Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1957-62. PMID: 24449899.
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    177. Chang YC, Olson J, Beasley FC, Tung C, Zhang J, Crocker PR, Varki A, Nizet V. Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog. 2014 Jan; 10(1):e1003846. PMID: 24391502.
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    178. Crotty Alexander LE, Marsh BJ, Timmer AM, Lin AE, Zainabadi K, Czopik A, Guarente L, Nizet V. Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One. 2013; 8(12):e84481. PMID: 24386389.
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    179. Sakoulas G, Rose W, Nonejuie P, Olson J, Pogliano J, Humphries R, Nizet V. Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2014; 58(3):1494-500. PMID: 24366742.
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    180. Franks SE, Ebrahimi C, Hollands A, Okumura CY, Aroian RV, Nizet V, McGillivray SM. Novel role for the yceGH tellurite resistance genes in the pathogenesis of Bacillus anthracis. Infect Immun. 2014 Mar; 82(3):1132-40. PMID: 24366250.
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    181. Anderson EL, Cole JN, Olson J, Ryba B, Ghosh P, Nizet V. The fibrinogen-binding M1 protein reduces pharyngeal cell adherence and colonization phenotypes of M1T1 group A Streptococcus. J Biol Chem. 2014 Feb 07; 289(6):3539-46. PMID: 24356958.
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    182. Barnett TC, Liebl D, Seymour LM, Gillen CM, Lim JY, Larock CN, Davies MR, Schulz BL, Nizet V, Teasdale RD, Walker MJ. The globally disseminated M1T1 clone of group A Streptococcus evades autophagy for intracellular replication. Cell Host Microbe. 2013 Dec 11; 14(6):675-82. PMID: 24331465.
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    183. Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T. Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J. 2014 Mar; 28(3):1280-93. PMID: 24308974.
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    184. Sakoulas G, Okumura CY, Thienphrapa W, Olson J, Nonejuie P, Dam Q, Dhand A, Pogliano J, Yeaman MR, Hensler ME, Bayer AS, Nizet V. Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl). 2014 Feb; 92(2):139-49. PMID: 24297496.
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    185. Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Lardone RD, Le D, Varki NM, Nizet V, Marth JD. Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20218-23. PMID: 24284176.
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    187. Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore BS. Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4407-16. PMID: 24191063.
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    188. Yamaguchi M, Terao Y, Mori-Yamaguchi Y, Domon H, Sakaue Y, Yagi T, Nishino K, Yamaguchi A, Nizet V, Kawabata S. Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS One. 2013; 8(10):e77282. PMID: 24194877.
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    189. Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17570-5. PMID: 24101470.
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    190. Sjögren J, Struwe WB, Cosgrave EF, Rudd PM, Stervander M, Allhorn M, Hollands A, Nizet V, Collin M. EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and a1-acid glycoprotein. Biochem J. 2013 Oct 01; 455(1):107-18. PMID: 23865566.
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    191. Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS. Epidermal deletion of HIF-2a stimulates wound closure. J Invest Dermatol. 2014 Mar; 134(3):801-808. PMID: 24037341.
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    192. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. PMID: 24034615.
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    193. Lin AE, Autran CA, Espanola SD, Bode L, Nizet V. Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis. 2014 Feb 01; 209(3):389-98. PMID: 23990566.
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    194. Nizet V, Yaksh T. Neuroscience: Bacteria get on your nerves. Nature. 2013 Sep 05; 501(7465):43-4. PMID: 23965630.
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    196. Leire E, Olson J, Isaacs H, Nizet V, Hollands A. Role of hypoxia inducible factor-1 in keratinocyte inflammatory response and neutrophil recruitment. J Inflamm (Lond). 2013 Aug 10; 10(1):28. PMID: 23937964.
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    197. Okumura CY, Anderson EL, Döhrmann S, Tran DN, Olson J, von Pawel-Rammingen U, Nizet V. IgG protease Mac/IdeS is not essential for phagocyte resistance or mouse virulence of M1T1 group A Streptococcus. MBio. 2013 Jul 30; 4(4). PMID: 23900173.
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    198. Berti AD, Sakoulas G, Nizet V, Tewhey R, Rose WE. ß-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Oct; 57(10):5005-12. PMID: 23896478.
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    199. Sanderson-Smith ML, Zhang Y, Ly D, Donahue D, Hollands A, Nizet V, Ranson M, Ploplis VA, Walker MJ, Castellino FJ. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLoS Pathog. 2013; 9(7):e1003469. PMID: 23853591.
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    200. Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013 Aug; 14(8):726-32. PMID: 23817552.
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    201. Sakoulas G, Nonejuie P, Nizet V, Pogliano J, Crum-Cianflone N, Haddad F. Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline. Antimicrob Agents Chemother. 2013 Aug; 57(8):4042-5. PMID: 23689728.
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    202. Bhandari T, Olson J, Johnson RS, Nizet V. HIF-1a influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination. J Mol Med (Berl). 2013 Oct; 91(10):1199-205. PMID: 23686259.
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    203. Tsatsaronis JA, Hollands A, Cole JN, Maamary PG, Gillen CM, Ben Zakour NL, Kotb M, Nizet V, Beatson SA, Walker MJ, Sanderson-Smith ML. Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus. FASEB J. 2013 Jul; 27(7):2633-43. PMID: 23531597.
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    204. Venturini C, Ong CL, Gillen CM, Ben-Zakour NL, Maamary PG, Nizet V, Beatson SA, Walker MJ. Acquisition of the Sda1-encoding bacteriophage does not enhance virulence of the serotype M1 Streptococcus pyogenes strain SF370. Infect Immun. 2013 Jun; 81(6):2062-9. PMID: 23529618.
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    205. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Succinate is an inflammatory signal that induces IL-1ß through HIF-1a. Nature. 2013 Apr 11; 496(7444):238-42. PMID: 23535595.
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    206. Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N. Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci. 2013 Sep; 70(17):3199-210. PMID: 23519826.
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    207. Jantsch J, Gerlach RG, Ensser A, Dahesh S, Popp I, Heeg C, Bleiziffer O, Merz T, Schulz T, Horch RE, Bogdan C, Nizet V, van der Linden M. Severe soft tissue infection caused by a non-beta-hemolytic Streptococcus pyogenes strain harboring a premature stop mutation in the sagC gene. J Clin Microbiol. 2013 Jun; 51(6):1962-5. PMID: 23515542.
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    208. Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Schuepbach RA, Zinkernagel AS. Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence. J Mol Med (Berl). 2013 Jul; 91(7):861-9. PMID: 23443671.
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    209. Baek KJ, Cho JY, Rosenthal P, Alexander LEC, Nizet V, Broide DH. Hypoxia potentiates allergen induction of HIF-1a, chemokines, airway inflammation, TGF-ß1, and airway remodeling in a mouse model. Clin Immunol. 2013 Apr; 147(1):27-37. PMID: 23499929.
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    210. van Sorge NM, Beasley FC, Gusarov I, Gonzalez DJ, von Köckritz-Blickwede M, Anik S, Borkowski AW, Dorrestein PC, Nudler E, Nizet V. Methicillin-resistant Staphylococcus aureus bacterial nitric-oxide synthase affects antibiotic sensitivity and skin abscess development. J Biol Chem. 2013 Mar 01; 288(9):6417-26. PMID: 23322784.
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    211. Crotty Alexander LE, Akong-Moore K, Feldstein S, Johansson P, Nguyen A, McEachern EK, Nicatia S, Cowburn AS, Olson J, Cho JY, Isaacs H, Johnson RS, Broide DH, Nizet V. Myeloid cell HIF-1a regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013 May; 91(5):637-44. PMID: 23250618.
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    212. Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):123-8. PMID: 23248302.
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    213. Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012; 8(10):e1003007. PMID: 23093945.
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    214. Dahesh S, Nizet V, Cole JN. Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A streptococcus. Virulence. 2012 Nov 15; 3(7):566-75. PMID: 23076332.
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    215. Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME. Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2012 Dec; 65(12):593-8. PMID: 23047246.
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    216. Hollands A, Gonzalez D, Leire E, Donald C, Gallo RL, Sanderson-Smith M, Dorrestein PC, Nizet V. A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides. J Biol Chem. 2012 Nov 30; 287(49):40891-7. PMID: 23038245.
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    217. Rose WE, Eickhoff JC, Shukla SK, Pantrangi M, Rooijakkers S, Cosgrove SE, Nizet V, Sakoulas G. Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia. J Infect Dis. 2012 Nov 15; 206(10):1604-11. PMID: 22966128.
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    218. Cole JN, Aziz RK, Kuipers K, Timmer AM, Nizet V, van Sorge NM. A conserved UDP-glucose dehydrogenase encoded outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus. J Bacteriol. 2012 Nov; 194(22):6154-61. PMID: 22961854.
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    219. Humphries RM, Kelesidis T, Tewhey R, Rose WE, Schork N, Nizet V, Sakoulas G. Genotypic and phenotypic evaluation of the evolution of high-level daptomycin nonsusceptibility in vancomycin-resistant Enterococcus faecium. Antimicrob Agents Chemother. 2012 Nov; 56(11):6051-3. PMID: 22948885.
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    220. Branitzki-Heinemann K, Okumura CY, Völlger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, Von Köckritz-Blickwede M. A novel role for the transcription factor HIF-1a in the formation of mast cell extracellular traps. Biochem J. 2012 Aug 15; 446(1):159-63. PMID: 22738198.
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    221. Akong-Moore K, Chow OA, von Köckritz-Blickwede M, Nizet V. Influences of chloride and hypochlorite on neutrophil extracellular trap formation. PLoS One. 2012; 7(8):e42984. PMID: 22912772.
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    222. Maamary PG, Ben Zakour NL, Cole JN, Hollands A, Aziz RK, Barnett TC, Cork AJ, Henningham A, Sanderson-Smith M, McArthur JD, Venturini C, Gillen CM, Kirk JK, Johnson DR, Taylor WL, Kaplan EL, Kotb M, Nizet V, Beatson SA, Walker MJ. Tracing the evolutionary history of the pandemic group A streptococcal M1T1 clone. FASEB J. 2012 Nov; 26(11):4675-84. PMID: 22878963.
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    223. Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. The pore-forming toxin ß hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812. PMID: 22829768.
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    224. Uchiyama S, Andreoni F, Schuepbach RA, Nizet V, Zinkernagel AS. DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition. PLoS Pathog. 2012; 8(6):e1002736. PMID: 22719247.
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    235. Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK. Cofactors required for TLR7- and TLR9-dependent innate immune responses. Cell Host Microbe. 2012 Mar 15; 11(3):306-18. PMID: 22423970.
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    312. Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem. 2009 May 08; 284(19):13004-12. PMID: 19286651.
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    313. Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26; 52(4):976-88. PMID: 19191557.
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    314. Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 2009; 1(3):202-14. PMID: 20375578.
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    315. Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. PMID: 19196661.
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    316. Sendi P, Johansson L, Dahesh S, Van-Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis. 2009 Feb; 15(2):223-32. PMID: 19193266.
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    317. Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielski A, Podbielbski A, Hasty DL, Dale JB. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One. 2009; 4(1):e4166. PMID: 19132104.
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    318. Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One. 2008; 3(12):e4102. PMID: 19116661.
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    319. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. PMID: 19001420.
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    320. Maisey HC, Doran KS, Nizet V. Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med. 2008 Sep 22; 10:e27. PMID: 18803886.
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    321. Nizet V, Rothenberg ME. Mitochondrial missile defense. Nat Med. 2008 Sep; 14(9):910-2. PMID: 18776879.
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    322. Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V. The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing. Cell Host Microbe. 2008 Aug 14; 4(2):170-8. PMID: 18692776.
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    323. Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. PLoS One. 2008 Jul 30; 3(7):e2824. PMID: 18665241.
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    324. Hensler ME, Miyamoto S, Nizet V. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One. 2008 Jun 18; 3(6):e2446. PMID: 18560574.
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    325. Dahesh S, Hensler ME, Van Sorge NM, Gertz RE, Schrag S, Nizet V, Beall BW. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob Agents Chemother. 2008 Aug; 52(8):2915-8. PMID: 18541727.
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    326. Kraus D, Herbert S, Kristian SA, Khosravi A, Nizet V, Götz F, Peschel A. The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses. BMC Microbiol. 2008 Jun 02; 8:85. PMID: 18518949.
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    327. Timmer AM, Nizet V. IKKbeta/NF-kappaB and the miscreant macrophage. J Exp Med. 2008 Jun 09; 205(6):1255-9. PMID: 18519650.
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    328. Gallo RL, Nizet V. Innate barriers against infection and associated disorders. Drug Discov Today Dis Mech. 2008 Jun 01; 5(2):145-152. PMID: 19492071.
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    329. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. PMID: 18511561.
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    330. Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008 Jun; 14(6):648-55. PMID: 18488037.
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    331. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192.
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    332. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. PMID: 18375757.
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    333. Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V. Strain-associated virulence factors of Streptococcus iniae in hybrid-striped bass. Vet Microbiol. 2008 Sep 18; 131(1-2):145-53. PMID: 18406547.
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    334. McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence. Science. 2008 Mar 07; 319(5868):1405-8. PMID: 18323455.
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    335. Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson RS. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol. 2008 Aug; 128(8):1964-8. PMID: 18323789.
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    336. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br J Dermatol. 2008 Mar; 158(3):442-55. PMID: 18275522.
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    337. Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 07; 319(5868):1391-4. PMID: 18276850.
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    338. Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol. 2008 Apr; 190(7):2275-8. PMID: 18223076.
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    339. Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran KS. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J. 2008 Jun; 22(6):1715-24. PMID: 18198218.
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    340. Zinkernagel AS, Peyssonnaux C, Johnson RS, Nizet V. Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes. J Infect Dis. 2008 Jan 15; 197(2):214-7. PMID: 18173364.
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    341. Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, Walker MJ. Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem. 2008 Mar 07; 283(10):6359-66. PMID: 18180300.
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    342. Peyssonnaux C, Nizet V, Johnson RS. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle. 2008 Jan 01; 7(1):28-32. PMID: 18212530.
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    343. Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ. Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics. 2007 Dec; 7(24):4488-98. PMID: 18072207.
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    344. Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl). 2007 Dec; 85(12):1339-46. PMID: 18030436.
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    345. Meluzzi D, Zheng WH, Hensler M, Nizet V, Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett. 2008 May 15; 18(10):3107-11. PMID: 18006314.
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    346. Hensler ME, Quach D, Hsieh CJ, Doran KS, Nizet V. CAMP factor is not essential for systemic virulence of Group B Streptococcus. Microb Pathog. 2008 Jan; 44(1):84-8. PMID: 17870297.
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    347. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. PMID: 17646166.
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    348. Walker MJ, Hollands A, Sanderson-Smith ML, Cole JN, Kirk JK, Henningham A, McArthur JD, Dinkla K, Aziz RK, Kansal RG, Simpson AJ, Buchanan JT, Chhatwal GS, Kotb M, Nizet V. DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med. 2007 Aug; 13(8):981-5. PMID: 17632528.
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    349. Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007 Oct 15; 110(8):3039-48. PMID: 17606764.
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    350. Nizet V. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. J Allergy Clin Immunol. 2007 Jul; 120(1):13-22. PMID: 17606031.
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    351. Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest. 2007 Jul; 117(7):1926-32. PMID: 17557118.
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    352. Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007 Jun 15; 178(12):7516-9. PMID: 17548584.
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    353. Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ. 2007 Jun 07; 76(1):17-26. PMID: 17718161.
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    354. Zinkernagel AS, Nizet V. Staphylococcus aureus: a blemish on skin immunity. Cell Host Microbe. 2007 May 17; 1(3):161-2. PMID: 18005694.
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    355. Kwinn LA, Nizet V. How group A Streptococcus circumvents host phagocyte defenses. Future Microbiol. 2007 Feb; 2(1):75-84. PMID: 17661677.
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    356. Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V. Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. FASEB J. 2007 Apr; 21(4):1107-16. PMID: 17215486.
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    357. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. PMID: 17170310.
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    358. Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus. J Bacteriol. 2007 Feb; 189(4):1322-9. PMID: 17114267.
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    359. Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT. Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol. 2007 Feb; 189(4):1279-87. PMID: 17098893.
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    360. Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL. Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides. Infect Immun. 2006 Nov; 74(11):6179-87. PMID: 17057092.
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    361. Dehority W, Uchiyama S, Khosravi A, Nizet V. Brain abscess caused by Streptococcus pyogenes in a previously healthy child. J Clin Microbiol. 2006 Dec; 44(12):4613-5. PMID: 17065264.
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    362. Maisey HC, Hensler M, Nizet V, Doran KS. Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells. J Bacteriol. 2007 Feb; 189(4):1464-7. PMID: 17041051.
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    363. Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. PMID: 16997964.
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    364. Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A, Hanski E. A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO J. 2006 Oct 04; 25(19):4628-37. PMID: 16977314.
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    365. Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V. Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Mol Microbiol. 2006 Oct; 62(1):15-25. PMID: 16942605.
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    366. Hensler ME, Bernstein G, Nizet V, Nefzi A. Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5073-9. PMID: 16890437.
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    367. Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, Rohde M, Itzek A, Sun H, Ginsburg D, Kotb M, Nizet V, Chhatwal GS, Walker MJ. Trigger for group A streptococcal M1T1 invasive disease. FASEB J. 2006 Aug; 20(10):1745-7. PMID: 16790522.
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    368. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35. PMID: 16497591.
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    369. Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol. 2006 Feb 21; 16(4):396-400. PMID: 16488874.
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    370. Lewis AL, Hensler ME, Varki A, Nizet V. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 2006 Apr 21; 281(16):11186-92. PMID: 16490781.
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    371. Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood. 2006 May 01; 107(9):3727-32. PMID: 16391018.
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    372. Nizet V. Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Curr Issues Mol Biol. 2006 Jan; 8(1):11-26. PMID: 16450883.
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    373. Dorschner RA, Lopez-Garcia B, Peschel A, Kraus D, Morikawa K, Nizet V, Gallo RL. The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides. FASEB J. 2006 Jan; 20(1):35-42. PMID: 16394265.
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    374. Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V. D-alanylation of teichoic acids promotes group a streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion. J Bacteriol. 2005 Oct; 187(19):6719-25. PMID: 16166534.
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    375. Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development. Infect Immun. 2005 Oct; 73(10):6935-44. PMID: 16177373.
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    376. Braff MH, Zaiou M, Fierer J, Nizet V, Gallo RL. Keratinocyte production of cathelicidin provides direct activity against bacterial skin pathogens. Infect Immun. 2005 Oct; 73(10):6771-81. PMID: 16177355.
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    377. Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J Clin Invest. 2005 Sep; 115(9):2499-507. PMID: 16138192.
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    378. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun. 2005 Aug; 73(8):4512-21. PMID: 16040962.
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    379. Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005 Jul 18; 202(2):209-15. PMID: 16009720.
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    380. Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005 Jul; 115(7):1806-15. PMID: 16007254.
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    381. Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol. 2005 Jul; 125(1):9-13. PMID: 15982297.
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    382. Datta V, Myskowski SM, Kwinn LA, Chiem DN, Varki N, Kansal RG, Kotb M, Nizet V. Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol Microbiol. 2005 May; 56(3):681-95. PMID: 15819624.
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    383. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. PMID: 15858576.
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    384. Hensler ME, Liu GY, Sobczak S, Benirschke K, Nizet V, Heldt GP. Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection. J Infect Dis. 2005 Apr 15; 191(8):1287-91. PMID: 15776375.
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    385. Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem. 2005 Mar 11; 280(10):9272-82. PMID: 15546886.
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    386. Doran KS, Nizet V. Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy. Mol Microbiol. 2004 Oct; 54(1):23-31. PMID: 15458402.
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    387. Liu GY, Doran KS, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14491-6. PMID: 15381763.
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    388. Lewis AL, Nizet V, Varki A. Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11123-8. PMID: 15263085.
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    389. Liu GY, Nizet V. Extracellular virulence factors of group B Streptococci. Front Biosci. 2004 May 01; 9:1794-802. PMID: 14977587.
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    390. Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther. 2004 Apr; 4(4):543-9. PMID: 15102603.
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    391. Hidalgo-Grass C, Dan-Goor M, Maly A, Eran Y, Kwinn LA, Nizet V, Ravins M, Jaffe J, Peyser A, Moses AE, Hanski E. Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet. 2004 Feb 28; 363(9410):696-703. PMID: 15001327.
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    392. Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M. Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol Microbiol. 2004 Jan; 51(1):123-34. PMID: 14651616.
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    393. Saitoh A, Beall B, Nizet V. Fulminant bacterial meningitis complicating sphenoid sinusitis. Pediatr Emerg Care. 2003 Dec; 19(6):415-7. PMID: 14676492.
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    394. Gallo RL, Nizet V. Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr Allergy Asthma Rep. 2003 Sep; 3(5):402-9. PMID: 12906776.
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    395. Doran KS, Liu GY, Nizet V. Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest. 2003 Sep; 112(5):736-44. PMID: 12952922.
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    396. Kristian SA, Lauth X, Nizet V, Goetz F, Neumeister B, Peschel A, Landmann R. Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model. J Infect Dis. 2003 Aug 01; 188(3):414-23. PMID: 12870123.
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    397. Zaiou M, Nizet V, Gallo RL. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol. 2003 May; 120(5):810-6. PMID: 12713586.
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    398. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. PMID: 12628185.
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    399. Jeng A, Sakota V, Li Z, Datta V, Beall B, Nizet V. Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX. J Bacteriol. 2003 Feb; 185(4):1208-17. PMID: 12562790.
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    400. Kansal RG, Nizet V, Jeng A, Chuang WJ, Kotb M. Selective modulation of superantigen-induced responses by streptococcal cysteine protease. J Infect Dis. 2003 Feb 01; 187(3):398-407. PMID: 12552423.
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    401. Nizet V, Gallo RL. Cathelicidins and innate defense against invasive bacterial infection. Scand J Infect Dis. 2003; 35(9):670-6. PMID: 14620153.
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    402. Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec; 10(12):575-80. PMID: 12564994.
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    403. Ring A, Depnering C, Pohl J, Nizet V, Shenep JL, Stremmel W. Synergistic action of nitric oxide release from murine macrophages caused by group B streptococcal cell wall and beta-hemolysin/cytolysin. J Infect Dis. 2002 Nov 15; 186(10):1518-21. PMID: 12404173.
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    404. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
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    406. Nizet V, Gallo RL. Surviving innate immunity. Trends Microbiol. 2002 Aug; 10(8):358-9. PMID: 12160630.
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    407. Doran KS, Benoit VM, Gertz RE, Beall B, Nizet V. Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis. J Perinatol. 2002 Jun; 22(4):326-30. PMID: 12032798.
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    408. Ring A, Braun JS, Pohl J, Nizet V, Stremmel W, Shenep JL. Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis. J Infect Dis. 2002 Jun 15; 185(12):1745-53. PMID: 12085320.
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    409. Humar D, Datta V, Bast DJ, Beall B, De Azavedo JC, Nizet V. Streptolysin S and necrotising infections produced by group G streptococcus. Lancet. 2002 Jan 12; 359(9301):124-9. PMID: 11809255.
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    410. Doran KS, Chang JC, Benoit VM, Eckmann L, Nizet V. Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis. 2002 Jan 15; 185(2):196-203. PMID: 11807693.
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    411. Henneke P, Takeuchi O, van Strijp JA, Guttormsen HK, Smith JA, Schromm AB, Espevik TA, Akira S, Nizet V, Kasper DL, Golenbock DT. Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol. 2001 Dec 15; 167(12):7069-76. PMID: 11739528.
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    412. Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15; 277(7):5030-9. PMID: 11739390.
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    413. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piraino J, Huttner K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 2001 Nov 22; 414(6862):454-7. PMID: 11719807.
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    414. Dorschner RA, Pestonjamasp VK, Tamakuwala S, Ohtake T, Rudisill J, Nizet V, Agerberth B, Gudmundsson GH, Gallo RL. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol. 2001 Jul; 117(1):91-7. PMID: 11442754.
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    415. Ballon-Landa GR, Gherardi G, Beall B, Krosner S, Nizet V. Necrotizing fasciitis due to penicillin-resistant Streptococcus pneumoniae: case report and review of the literature. J Infect. 2001 May; 42(4):272-7. PMID: 11545571.
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    416. Fuller JD, Bast DJ, Nizet V, Low DE, de Azavedo JC. Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun. 2001 Apr; 69(4):1994-2000. PMID: 11254550.
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    417. Pritzlaff CA, Chang JC, Kuo SP, Tamura GS, Rubens CE, Nizet V. Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus. Mol Microbiol. 2001 Jan; 39(2):236-47. PMID: 11136446.
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    418. Puliti M, Nizet V, von Hunolstein C, Bistoni F, Mosci P, Orefici G, Tissi L. Severity of group B streptococcal arthritis is correlated with beta-hemolysin expression. J Infect Dis. 2000 Sep; 182(3):824-32. PMID: 10950777.
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    419. Nizet V, Beall B, Bast DJ, Datta V, Kilburn L, Low DE, De Azavedo JC. Genetic locus for streptolysin S production by group A streptococcus. Infect Immun. 2000 Jul; 68(7):4245-54. PMID: 10858242.
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    420. Ring A, Braun JS, Nizet V, Stremmel W, Shenep JL. Group B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages. J Infect Dis. 2000 Jul; 182(1):150-7. PMID: 10882592.
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    421. Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun. 2000 Feb; 68(2):637-43. PMID: 10639427.
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    422. Gibson RL, Nizet V, Rubens CE. Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells. Pediatr Res. 1999 May; 45(5 Pt 1):626-34. PMID: 10231855.
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    423. Nizet V, Kim KS, Stins M, Jonas M, Chi EY, Nguyen D, Rubens CE. Invasion of brain microvascular endothelial cells by group B streptococci. Infect Immun. 1997 Dec; 65(12):5074-81. PMID: 9393798.
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    424. Nizet V, Gibson RL, Rubens CE. The role of group B streptococci beta-hemolysin expression in newborn lung injury. Adv Exp Med Biol. 1997; 418:627-30. PMID: 9331730.
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    425. La Penta D, Framson P, Nizet V, Rubens C. Epithelial cell invasion by group B streptococci is important to virulence. Adv Exp Med Biol. 1997; 418:631-4. PMID: 9331731.
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    426. Nizet V, Gibson RL, Chi EY, Framson PE, Hulse M, Rubens CE. Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells. Infect Immun. 1996 Sep; 64(9):3818-26. PMID: 8751934.
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    427. Mills WJ, Mosca VS, Nizet V. Orthopaedic manifestations of invasive group A streptococcal infections complicating primary varicella. J Pediatr Orthop. 1996 Jul-Aug; 16(4):522-8. PMID: 8784712.
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    428. Brogan TV, Nizet V, Waldhausen JH. Streptococcal skin infections. N Engl J Med. 1996 May 30; 334(22):1478. PMID: 8618597.
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    429. Nizet V, Colina KF, Almquist JR, Rubens CE, Smith AL. A virulent nonencapsulated Haemophilus influenzae. J Infect Dis. 1996 Jan; 173(1):180-6. PMID: 8537657.
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    430. Brogan TV, Nizet V, Waldhausen JH, Rubens CE, Clarke WR. Group A streptococcal necrotizing fasciitis complicating primary varicella: a series of fourteen patients. Pediatr Infect Dis J. 1995 Jul; 14(7):588-94. PMID: 7567287.
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    431. Nizet V, Priebe CJ. A newborn girl with watery diarrhea, weight loss, and severe metabolic acidosis. Curr Opin Pediatr. 1994 Apr; 6(2):163-7. PMID: 8032396.
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    432. Nizet V, Vinci RJ, Lovejoy FH. Fever in children. Pediatr Rev. 1994 Apr; 15(4):127-35. PMID: 8015996.
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    433. Priebe CJ, Nizet V. A 5-year-old girl with varicella and acute onset of fever, stridor, and respiratory distress. Curr Opin Pediatr. 1994 Feb; 6(1):36-41. PMID: 8205172.
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    434. Priebe CJ, Nizet V. A 7-month-old boy with poor growth, hypercalcemia, and unusual facies. Curr Opin Pediatr. 1993 Dec; 5(6):728-32. PMID: 8124427.
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    435. Lovejoy FH, Nizet V, Priebe CJ. Common etiologies and new approaches to management of poisoning in pediatric practice. Curr Opin Pediatr. 1993 Oct; 5(5):524-30. PMID: 8287075.
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    436. Priebe CJ, Nizet V. A 2-year-old girl with hematemesis, melena, and splenomegaly. Curr Opin Pediatr. 1993 Oct; 5(5):590-4. PMID: 8287083.
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    437. Nizet V, Priebe CJ. An 8-day-old male infant with poor feeding, lethargy, and an elevated anion gap metabolic acidosis. Curr Opin Pediatr. 1993 Aug; 5(4):499-502. PMID: 8374680.
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    438. Palefsky JM, Winkler B, Rabanus JP, Clark C, Chan S, Nizet V, Schoolnik GK. Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues. J Clin Invest. 1991 Jun; 87(6):2132-41. PMID: 1645754.
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