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    Victor Nizet

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
    Phone858-534-7408
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      Collapse Biography 
      Collapse Awards and Honors
      2013UCSD Chancellor's Award for Excellence in Postdoctoral Scholar Mentoring
      2013Rady Children’s Hospital Award for Excellence in Research
      2012Elected to Fellowship in the American Academy of Microbiology
      2010Elected to Membership in the Association of American Physicians
      2008E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research
      2008Stephen Silberstein Senior Fellow of the American Asthma Foundation
      2006Elected to Membership in the American Society for Clinical Investigation
      2006Elected to the American Pediatric Society
      2004Career Investigator Award, American Lung Association
      2004Established Investigator Award, American Heart Association
      2002Named the 39th Mallinckrodt Scholar by the Edward Mallinckrodt, Jr. Foundation
      2002Pediatric Infectious Diseases Society Young Investigator Award
      2002Elected to the Society for Pediatric Research
      2001UCSD Department of Pediatrics Commitment to Resident Education Award
      2000UCSD Department of Pediatrics Outstanding Faculty Teacher of the Year
      1993Sidney Farber Outstanding Houseofficer Award, Children’s Hospital, Boston
      1984Class of 1922 Award, Reed College, “Most Outstanding Senior Thesis”
      1984Phi Beta Kappa, Reed College

      Collapse Overview 
      Collapse Overview
      Victor Nizet is a Professor of Pediatrics and Pharmacy at the University of California, San Diego and Chief of the Division of Pediatric Pharmacology & Drug Discovery at University of California San Diego (UCSD) School of Medicine and Skaggs School of Pharmacy & Pharmaceutical Sciences. Dr. Nizet received his medical training at Stanford University School of Medicine, completed a Residency and Chief Residency in Pediatrics at Harvard University's Children's Hospital in Boston, Massachusetts, and a Fellowship in Pediatric Infectious Diseases at the University of Washington's Children's Hospital in Seattle. Dr. Nizet joined the UCSD faculty in 1997 and leads a large basic and translational research laboratory focused on discovering virulence factors of Gram-positive bacterial pathogens, elucidating mechanisms of host innate immunity, and novel approaches to infectious disease therapy.

      Collapse Interests

      Collapse Research 
      Collapse Research Activities and Funding
      Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases
      NIH/NICHD U54HD090259Sep 20, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Glycoprotein Remodeling in the Vasculopathy and Coagulopathy of Sepsis
      NIH/NHLBI R01HL125352Sep 15, 2014 - May 31, 2019
      Role: Principal Investigator
      Analyzing a novel mechanism of action of bacterial cAMP producing toxins
      NIH/NIAID R01AI110713Feb 1, 2014 - Jan 31, 2019
      Role: Principal Investigator
      Glycan Modulation of Inflammatory Responses
      NIH P01HL107150Jul 1, 2011 - May 31, 2018
      Role: Co-Investigator
      Mechanisms of the M protein in group A Streptococcus virulence
      NIH/NIAID R01AI096837Jul 1, 2011 - Jun 30, 2016
      Role: Principal Investigator
      Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
      NIH/NIAID R01AI093451Apr 5, 2011 - Mar 31, 2016
      Role: Principal Investigator
      Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
      NIH/NIAID R56AI090863Aug 2, 2010 - Jul 31, 2011
      Role: Principal Investigator
      GAS Switch from Colonizing Bacterium to Invasive Pathogen
      NIH/NIAID R01AI077780Sep 1, 2008 - Jan 31, 2020
      Role: Principal Investigator
      Sialic Acid O-Acetylation in GBS Pathogenesis &Immunity
      NIH/NICHD R01HD051796Apr 7, 2006 - Feb 28, 2012
      Role: Principal Investigator
      Molecular Analyses and Interventions for Biodefense and Emerging Pathogens
      NIH U54AI057153Sep 4, 2003 - Feb 28, 2014
      Role: Co-Investigator
      Cathelicidin in Skin Immunity
      NIH/NIAID R01AI052453Sep 15, 2002 - Mar 31, 2018
      Role: Principal Investigator
      SLS: Molecular Basis and Role in Invasive GAS Disease
      NIH/NIAID R01AI048694Apr 1, 2002 - Mar 31, 2007
      Role: Principal Investigator
      PENETRATION OF THE BLOOD BRAIN BARRIER IN GBS MENINGITIS
      NIH/NICHD R03HD037224Feb 1, 1999 - Aug 31, 2001
      Role: Principal Investigator
      MOLECULAR BASIS OF LUNG INJURY IN GBS PNEUMONIA
      NIH/NIAID K08AI001451Apr 1, 1997 - Mar 31, 2001
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Guichard A, Jain P, Moayeri M, Schwartz R, Chin S, Zhu L, Cruz-Moreno B, Liu JZ, Aguilar B, Hollands A, Leppla SH, Nizet V, Bier E. Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 2017 Sep; 13(9):e1006603. PMID: 28945820.
        View in: PubMed
      2. Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Antimicrob Agents Chemother. 2017 Oct; 61(10). PMID: 28807909.
        View in: PubMed
      3. Sun J, Lei L, Tsai CM, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim TJ, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y. Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions. Nat Commun. 2017 Sep 07; 8(1):477. PMID: 28883531.
        View in: PubMed
      4. Munguia J, LaRock DL, Tsunemoto H, Olson J, Cornax I, Pogliano J, Nizet V. The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance. J Mol Med (Berl). 2017 Aug 26. PMID: 28844103.
        View in: PubMed
      5. Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunol Cell Biol. 2017 Aug 22. PMID: 28829050.
        View in: PubMed
      6. Valderrama JA, Riestra AM, Gao NJ, LaRock CN, Gupta N, Ali SR, Hoffman HM, Ghosh P, Nizet V. Group A streptococcal M protein activates the NLRP3 inflammasome. Nat Microbiol. 2017 Aug 07. PMID: 28784982.
        View in: PubMed
      7. Escajadillo T, Olson J, Luk BT, Zhang L, Nizet V. A Red Blood Cell Membrane-Camouflaged Nanoparticle Counteracts Streptolysin O-Mediated Virulence Phenotypes of Invasive Group A Streptococcus. Front Pharmacol. 2017; 8:477. PMID: 28769806.
        View in: PubMed
      8. Nizet V. The Accidental Orthodoxy of Drs. Mueller and Hinton. EBioMedicine. 2017 Aug; 22:26-27. PMID: 28689739.
        View in: PubMed
      9. Severino P, Ariga SK, Barbeiro HV, de Lima TM, de Paula Silva E, Barbeiro DF, Machado MCC, Nizet V, Pinheiro da Silva F. Cathelicidin-deficient mice exhibit increased survival and upregulation of key inflammatory response genes following cecal ligation and puncture. J Mol Med (Berl). 2017 Jun 16. PMID: 28623379.
        View in: PubMed
      10. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Erratum: Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2017 Jun 12; 2:17107. PMID: 28604710.
        View in: PubMed
      11. Rose WE, Shukla SK, Berti AD, Hayney MS, Henriquez KM, Ranzoni A, Cooper MA, Proctor RA, Nizet V, Sakoulas G. Increased Endovascular Staphylococcus aureus Inoculum Is the Link Between Elevated Serum Interleukin 10 Concentrations and Mortality in Patients With Bacteremia. Clin Infect Dis. 2017 May 15; 64(10):1406-1412. PMID: 28205673.
        View in: PubMed
      12. Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P, Deng L, Nizet V, Varki A. Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation. Blood. 2017 Jun 08; 129(23):3100-3110. PMID: 28416510.
        View in: PubMed
      13. Lin AE, Autran CA, Szyszka A, Escajadillo T, Huang M, Godula K, Prudden AR, Boons GJ, Lewis AL, Doran KS, Nizet V, Bode L. Human milk oligosaccharides inhibit growth of group B Streptococcus. J Biol Chem. 2017 Jul 07; 292(27):11243-11249. PMID: 28416607.
        View in: PubMed
      14. Storisteanu DM, Pocock JM, Cowburn AS, Juss JK, Nadesalingam A, Nizet V, Chilvers ER. Evasion of Neutrophil Extracellular Traps by Respiratory Pathogens. Am J Respir Cell Mol Biol. 2017 Apr; 56(4):423-431. PMID: 27854516.
        View in: PubMed
      15. Munguia J, Nizet V. Pharmacological Targeting of the Host-Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs. Trends Pharmacol Sci. 2017 May; 38(5):473-488. PMID: 28283200.
        View in: PubMed
      16. Lawrence SM, Corriden R, Nizet V. Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil. Front Pediatr. 2017; 5:23. PMID: 28293548.
        View in: PubMed
      17. Caffrey AR, Timbrook TT, Noh E, Sakoulas G, Opal SM, Nizet V, LaPlante KL. Evidence To Support Continuation of Statin Therapy in Patients with Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2017 Mar; 61(3). PMID: 28069650.
        View in: PubMed
      18. Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A. Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State. J Immunol. 2017 Mar 15; 198(6):2366-2373. PMID: 28148732.
        View in: PubMed
      19. De Oliveira DM, Hartley-Tassell L, Everest-Dass A, Day CJ, Dabbs RA, Ve T, Kobe B, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML. Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization. MBio. 2017 Jan 24; 8(1). PMID: 28119471.
        View in: PubMed
      20. Sakoulas G, Rose W, Berti A, Olson J, Munguia J, Nonejuie P, Sakoulas E, Rybak MJ, Pogliano J, Nizet V. Classical ß-Lactamase Inhibitors Potentiate the Activity of Daptomycin against Methicillin-Resistant Staphylococcus aureus and Colistin against Acinetobacter baumannii. Antimicrob Agents Chemother. 2017 Feb; 61(2). PMID: 27872080.
        View in: PubMed
      21. Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A. Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017 Mar 15; 36(6):751-760. PMID: 28100677.
        View in: PubMed
      22. van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin a2 as a Host Factor for Bacterial Invasion. MBio. 2017 Jan 10; 8(1). PMID: 28074024.
        View in: PubMed
      23. Askarian F, Uchiyama S, Valderrama JA, Ajayi C, Sollid JU, van Sorge NM, Nizet V, van Strijp JA, Johannessen M. Serine-Aspartate Repeat Protein D Increases Staphylococcus aureus Virulence and Survival in Blood. Infect Immun. 2017 Jan; 85(1). PMID: 27795358.
        View in: PubMed
      24. Sorg RA, Lin L, van Doorn GS, Sorg M, Olson J, Nizet V, Veening JW. Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation. PLoS Biol. 2016 Dec; 14(12):e2000631. PMID: 28027306.
        View in: PubMed
      25. Flores R, Döhrmann S, Schaal C, Hakkim A, Nizet V, Corriden R. The Selective Estrogen Receptor Modulator Raloxifene Inhibits Neutrophil Extracellular Trap Formation. Front Immunol. 2016; 7:566. PMID: 28003814.
        View in: PubMed
      26. Coady A, Nizet V. SAMP-ending down sepsis. Ann Transl Med. 2016 Dec; 4(24):509. PMID: 28149871.
        View in: PubMed
      27. Sakoulas G, Olson J, Yim J, Singh NB, Kumaraswamy M, Quach DT, Rybak MJ, Pogliano J, Nizet V. Cefazolin and Ertapenem, a Synergistic Combination Used To Clear Persistent Staphylococcus aureus Bacteremia. Antimicrob Agents Chemother. 2016 Nov; 60(11):6609-6618. PMID: 27572414.
        View in: PubMed
      28. Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P. Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein. Nat Microbiol. 2016 Sep 05; 1(11):16155. PMID: 27595425.
        View in: PubMed
      29. Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B. Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR. Cell Host Microbe. 2016 Sep 14; 20(3):307-317. PMID: 27593514; PMCID: PMC5025396 [Available on 09/14/17].
      30. LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V. IL-1ß is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016 Aug; 1(2). PMID: 28331908.
        View in: PubMed
      31. LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AAB, Cooper MA, Hoffman HM, Nizet V. IL-1ß is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016 Aug 19; 1(2):eaah3539. PMID: 28783696.
        View in: PubMed
      32. Stewart CM, Buffalo CZ, Valderrama JA, Henningham A, Cole JN, Nizet V, Ghosh P. Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction. Proc Natl Acad Sci U S A. 2016 Aug 23; 113(34):9515-20. PMID: 27512043; PMCID: PMC5003295 [Available on 02/23/17].
      33. Döhrmann S, Cole JN, Nizet V. Conquering Neutrophils. PLoS Pathog. 2016 Jul; 12(7):e1005682. PMID: 27467389; PMCID: PMC4965185.
      34. Yamaguchi M, Hirose Y, Nakata M, Uchiyama S, Yamaguchi Y, Goto K, Sumitomo T, Lewis AL, Kawabata S, Nizet V. Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep. 2016 Jun 29; 6:28852. PMID: 27352769; PMCID: PMC4926279.
      35. Lin L, Kim J, Chen H, Kowalski R, Nizet V. Component Analysis of Multipurpose Contact Lens Solutions To Enhance Activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antimicrob Agents Chemother. 2016 Jul; 60(7):4259-63. PMID: 27139484; PMCID: PMC4914654 [Available on 01/01/17].
      36. Rivera-Hernandez T, Pandey M, Henningham A, Cole J, Choudhury B, Cork AJ, Gillen CM, Ghaffar KA, West NP, Silvestri G, Good MF, Moyle PM, Toth I, Nizet V, Batzloff MR, Walker MJ. Differing Efficacies of Lead Group A Streptococcal Vaccine Candidates and Full-Length M Protein in Cutaneous and Invasive Disease Models. MBio. 2016 Jun 14; 7(3). PMID: 27302756; PMCID: PMC4916377.
      37. Bosi E, Monk JM, Aziz RK, Fondi M, Nizet V, Palsson BØ. Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3801-9. PMID: 27286824; PMCID: PMC4932939.
      38. Carey AJ, Weinberg JB, Dawid SR, Venturini C, Lam AK, Nizet V, Caparon MG, Walker MJ, Watson ME, Ulett GC. Interleukin-17A Contributes to the Control of Streptococcus pyogenes Colonization and Inflammation of the Female Genital Tract. Sci Rep. 2016 May 31; 6:26836. PMID: 27241677; PMCID: PMC4886215.
      39. Völlger L, Akong-Moore K, Cox L, Goldmann O, Wang Y, Schäfer ST, Naim HY, Nizet V, von Köckritz-Blickwede M. Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep. 2016 Jul; 36(3). PMID: 27129288.
        View in: PubMed
      40. Huang YM, Miao Y, Munguia J, Lin L, Nizet V, McCammon JA. Molecular dynamic study of MlaC protein in Gram-negative bacteria: conformational flexibility, solvent effect and protein-phospholipid binding. Protein Sci. 2016 08; 25(8):1430-7. PMID: 27111825; PMCID: PMC4972199 [Available on 08/01/17].
      41. Hollands A, Corriden R, Gysler G, Dahesh S, Olson J, Raza Ali S, Kunkel MT, Lin AE, Forli S, Newton AC, Kumar GB, Nair BG, Perry JJ, Nizet V. Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem. 2016 Jul 01; 291(27):13964-73. PMID: 27226531; PMCID: PMC4933157 [Available on 07/01/17].
      42. von Köckritz-Blickwede M, Blodkamp S, Nizet V. Interaction of Bacterial Exotoxins with Neutrophil Extracellular Traps: Impact for the Infected Host. Front Microbiol. 2016; 7:402. PMID: 27064864; PMCID: PMC4811905.
      43. Cole JN, Nizet V. Bacterial Evasion of Host Antimicrobial Peptide Defenses. Microbiol Spectr. 2016 Feb; 4(1). PMID: 26999396; PMCID: PMC4804471 [Available on 02/01/17].
      44. Kumaraswamy M, Lin L, Olson J, Sun CF, Nonejuie P, Corriden R, Döhrmann S, Ali SR, Amaro D, Rohde M, Pogliano J, Sakoulas G, Nizet V. Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia. J Antimicrob Chemother. 2016 May; 71(5):1264-9. PMID: 26832758; PMCID: PMC4830416 [Available on 05/01/17].
      45. Kolar SL, Kyme P, Tseng CW, Soliman A, Kaplan A, Liang J, Nizet V, Jiang D, Murali R, Arditi M, Underhill DM, Liu GY. Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan. Cell Host Microbe. 2015 Dec 09; 18(6):694-704. PMID: 26651945; PMCID: PMC4683412 [Available on 12/09/16].
      46. Barnett TC, Cole JN, Rivera-Hernandez T, Henningham A, Paton JC, Nizet V, Walker MJ. Streptococcal toxins: role in pathogenesis and disease. Cell Microbiol. 2015 Dec; 17(12):1721-41. PMID: 26433203.
        View in: PubMed
      47. Uchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015; 6:581. PMID: 26635795; PMCID: PMC4644796.
      48. Berti AD, Theisen E, Sauer JD, Nonejuie P, Olson J, Pogliano J, Sakoulas G, Nizet V, Proctor RA, Rose WE. Penicillin Binding Protein 1 Is Important in the Compensatory Response of Staphylococcus aureus to Daptomycin-Induced Membrane Damage and Is a Potential Target for ß-Lactam-Daptomycin Synergy. Antimicrob Agents Chemother. 2015 Nov 02; 60(1):451-8. PMID: 26525797; PMCID: PMC4704217.
      49. LaRock CN, Döhrmann S, Todd J, Corriden R, Olson J, Johannssen T, Lepenies B, Gallo RL, Ghosh P, Nizet V. Group A Streptococcal M1 Protein Sequesters Cathelicidin to Evade Innate Immune Killing. Cell Host Microbe. 2015 Oct 14; 18(4):471-7. PMID: 26468750; PMCID: PMC4636435 [Available on 10/14/16].
      50. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015 Oct 13; 6:8369. PMID: 26458291; PMCID: PMC4610010.
      51. Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A. Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J. 2015 Nov 12; 34(22):2775-88. PMID: 26459514; PMCID: PMC4682649 [Available on 11/12/16].
      52. LaRock CN, Nizet V. Inflammasome/IL-1ß Responses to Streptococcal Pathogens. Front Immunol. 2015; 6:518. PMID: 26500655; PMCID: PMC4597127.
      53. Secundino I, Lizcano A, Roupé KM, Wang X, Cole JN, Olson J, Ali SR, Dahesh S, Amayreh LK, Henningham A, Varki A, Nizet V. Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation. J Mol Med (Berl). 2016 Feb; 94(2):219-33. PMID: 26411873; PMCID: PMC4766071 [Available on 02/01/17].
      54. Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J. Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes. J Cell Biol. 2015 Sep 28; 210(7):1117-31. PMID: 26391660; PMCID: PMC4586747.
      55. Pence MA, Haste NM, Meharena HS, Olson J, Gallo RL, Nizet V, Kristian SA. Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PLoS One. 2015; 10(8):e0136605. PMID: 26305782; PMCID: PMC4549145.
      56. Sakoulas G, Kumaraswamy M, Nonejuie P, Werth BJ, Rybak MJ, Pogliano J, Rice LB, Nizet V. Differential Effects of Penicillin Binding Protein Deletion on the Susceptibility of Enterococcus faecium to Cationic Peptide Antibiotics. Antimicrob Agents Chemother. 2015 Oct; 59(10):6132-9. PMID: 26195528; PMCID: PMC4576044.
      57. Nizet V. Stopping superbugs, maintaining the microbiota. Sci Transl Med. 2015 Jul 08; 7(295):295ed8. PMID: 26157027.
        View in: PubMed
      58. Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56. PMID: 26150541; PMCID: PMC4534644.
      59. Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chem Biol. 2015 Jun 18; 22(6):785-92. PMID: 26091171; PMCID: PMC4475277.
      60. Lin L, Nonejuie P, Munguia J, Hollands A, Olson J, Dam Q, Kumaraswamy M, Rivera H, Corriden R, Rohde M, Hensler ME, Burkart MD, Pogliano J, Sakoulas G, Nizet V. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. EBioMedicine. 2015 Jul; 2(7):690-8. PMID: 26288841; PMCID: PMC4534682.
      61. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore BS. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. PMID: 25930739; PMCID: PMC4545249.
      62. Hindler JA, Wong-Beringer A, Charlton CL, Miller SA, Kelesidis T, Carvalho M, Sakoulas G, Nonejuie P, Pogliano J, Nizet V, Humphries R. In vitro activity of daptomycin in combination with ß-lactams, gentamicin, rifampin, and tigecycline against daptomycin-nonsusceptible enterococci. Antimicrob Agents Chemother. 2015 Jul; 59(7):4279-88. PMID: 25963982; PMCID: PMC4468720.
      63. Kristian SA, Hwang JH, Hall B, Leire E, Iacomini J, Old R, Galili U, Roberts C, Mullis KB, Westby M, Nizet V. Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer. J Mol Med (Berl). 2015 Jun; 93(6):619-31. PMID: 25940316; PMCID: PMC4469262.
      64. Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V. Role of Hypoxia Inducible Factor-1a (HIF-1a) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr; 11(4):e1004818. PMID: 25927232; PMCID: PMC4415805.
      65. McEachern EK, Hwang JH, Sladewski KM, Nicatia S, Dewitz C, Mathew DP, Nizet V, Crotty Alexander LE. Analysis of the effects of cigarette smoke on staphylococcal virulence phenotypes. Infect Immun. 2015 Jun; 83(6):2443-52. PMID: 25824841; PMCID: PMC4432760.
      66. Harbut MB, Vilchèze C, Luo X, Hensler ME, Guo H, Yang B, Chatterjee AK, Nizet V, Jacobs WR, Schultz PG, Wang F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4453-8. PMID: 25831516; PMCID: PMC4394260.
      67. Lin AE, Beasley FC, Keller N, Hollands A, Urbano R, Troemel ER, Hoffman HM, Nizet V. A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1ß-dependent macrophage immune response. MBio. 2015 Mar 10; 6(2):e00133. PMID: 25759502; PMCID: PMC4453525.
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      142. Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012; 8(10):e1003007. PMID: 23093945; PMCID: PMC3475677.
      143. Dahesh S, Nizet V, Cole JN. Study of streptococcal hemoprotein receptor (Shr) in iron acquisition and virulence of M1T1 group A streptococcus. Virulence. 2012 Nov 15; 3(7):566-75. PMID: 23076332; PMCID: PMC3545933.
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      226. Uchiyama S, Carlin AF, Khosravi A, Weiman S, Banerjee A, Quach D, Hightower G, Mitchell TJ, Doran KS, Nizet V. The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion. J Exp Med. 2009 Aug 31; 206(9):1845-52. PMID: 19687228; PMCID: PMC2737157.
      227. Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: phenotypic and functional impact. Glycobiology. 2009 Nov; 19(11):1204-13. PMID: 19643844; PMCID: PMC2757575.
      228. Lewis AL, Desa N, Hansen EE, Knirel YA, Gordon JI, Gagneux P, Nizet V, Varki A. Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13552-7. PMID: 19666579; PMCID: PMC2726416.
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      230. Tseng CW, Kyme P, Low J, Rocha MA, Alsabeh R, Miller LG, Otto M, Arditi M, Diep BA, Nizet V, Doherty TM, Beenhouwer DO, Liu GY. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One. 2009 Jul 27; 4(7):e6387. PMID: 19633710; PMCID: PMC2711303.
      231. Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med. 2009 Aug 03; 206(8):1691-9. PMID: 19596804; PMCID: PMC2722167.
      232. Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 09; 52(13):3869-80. PMID: 19456099; PMCID: PMC2753857.
      233. McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V. ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis. J Innate Immun. 2009; 1(5):494-506. PMID: 20375606; PMCID: PMC2920483.
      234. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. PMID: 19541630; PMCID: PMC2722361.
      235. von Köckritz-Blickwede M, Nizet V. Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps. J Mol Med (Berl). 2009 Aug; 87(8):775-83. PMID: 19444424; PMCID: PMC2707954.
      236. van Sorge NM, Quach D, Gurney MA, Sullam PM, Nizet V, Doran KS. The group B streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. J Infect Dis. 2009 May 15; 199(10):1479-87. PMID: 19392623; PMCID: PMC2674616.
      237. Cox KH, Ruiz-Bustos E, Courtney HS, Dale JB, Pence MA, Nizet V, Aziz RK, Gerling I, Price SM, Hasty DL. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One. 2009; 4(4):e5366. PMID: 19401780; PMCID: PMC2671602.
      238. Pinheiro da Silva F, Gallo RL, Nizet V. Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling. Immunol Cell Biol. 2009 Aug-Sep; 87(6):496-500. PMID: 19350049; PMCID: PMC2763337.
      239. Navarini AA, Lang KS, Verschoor A, Recher M, Zinkernagel AS, Nizet V, Odermatt B, Hengartner H, Zinkernagel RM. Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7107-12. PMID: 19351895; PMCID: PMC2678456.
      240. Pinheiro da Silva F, Nizet V. Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection. Apoptosis. 2009 Apr; 14(4):509-21. PMID: 19199035.
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      242. Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26; 52(4):976-88. PMID: 19191557; PMCID: PMC2765255.
      243. Lauth X, von Köckritz-Blickwede M, McNamara CW, Myskowski S, Zinkernagel AS, Beall B, Ghosh P, Gallo RL, Nizet V. M1 protein allows Group A streptococcal survival in phagocyte extracellular traps through cathelicidin inhibition. J Innate Immun. 2009; 1(3):202-14. PMID: 20375578; PMCID: PMC3241932.
      244. Carlin AF, Uchiyama S, Chang YC, Lewis AL, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009 Apr 02; 113(14):3333-6. PMID: 19196661; PMCID: PMC2665898.
      245. Sendi P, Johansson L, Dahesh S, Van-Sorge NM, Darenberg J, Norgren M, Sjölin J, Nizet V, Norrby-Teglund A. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis. 2009 Feb; 15(2):223-32. PMID: 19193266; PMCID: PMC2657631.
      246. Courtney HS, Ofek I, Penfound T, Nizet V, Pence MA, Kreikemeyer B, Podbielski A, Podbielbski A, Hasty DL, Dale JB. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS One. 2009; 4(1):e4166. PMID: 19132104; PMCID: PMC2613554.
      247. Hollands A, Aziz RK, Kansal R, Kotb M, Nizet V, Walker MJ. A naturally occurring mutation in ropB suppresses SpeB expression and reduces M1T1 group A streptococcal systemic virulence. PLoS One. 2008; 3(12):e4102. PMID: 19116661; PMCID: PMC2605554.
      248. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. PMID: 19001420; PMCID: PMC2613605.
      249. Maisey HC, Doran KS, Nizet V. Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med. 2008 Sep 22; 10:e27. PMID: 18803886; PMCID: PMC2676346.
      250. Nizet V, Rothenberg ME. Mitochondrial missile defense. Nat Med. 2008 Sep; 14(9):910-2. PMID: 18776879.
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      251. Zinkernagel AS, Timmer AM, Pence MA, Locke JB, Buchanan JT, Turner CE, Mishalian I, Sriskandan S, Hanski E, Nizet V. The IL-8 protease SpyCEP/ScpC of group A Streptococcus promotes resistance to neutrophil killing. Cell Host Microbe. 2008 Aug 14; 4(2):170-8. PMID: 18692776; PMCID: PMC2631432.
      252. Locke JB, Aziz RK, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae M-like protein contributes to virulence in fish and is a target for live attenuated vaccine development. PLoS One. 2008 Jul 30; 3(7):e2824. PMID: 18665241; PMCID: PMC2483786.
      253. Hensler ME, Miyamoto S, Nizet V. Group B streptococcal beta-hemolysin/cytolysin directly impairs cardiomyocyte viability and function. PLoS One. 2008 Jun 18; 3(6):e2446. PMID: 18560574; PMCID: PMC2409074.
      254. Dahesh S, Hensler ME, Van Sorge NM, Gertz RE, Schrag S, Nizet V, Beall BW. Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics. Antimicrob Agents Chemother. 2008 Aug; 52(8):2915-8. PMID: 18541727; PMCID: PMC2493126.
      255. Kraus D, Herbert S, Kristian SA, Khosravi A, Nizet V, Götz F, Peschel A. The GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses. BMC Microbiol. 2008 Jun 02; 8:85. PMID: 18518949; PMCID: PMC2430206.
      256. Timmer AM, Nizet V. IKKbeta/NF-kappaB and the miscreant macrophage. J Exp Med. 2008 Jun 09; 205(6):1255-9. PMID: 18519650; PMCID: PMC2413023.
      257. Gallo RL, Nizet V. Innate barriers against infection and associated disorders. Drug Discov Today Dis Mech. 2008 Jun 01; 5(2):145-152. PMID: 19492071.
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      258. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. PMID: 18511561; PMCID: PMC2409384.
      259. Grewal PK, Uchiyama S, Ditto D, Varki N, Le DT, Nizet V, Marth JD. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008 Jun; 14(6):648-55. PMID: 18488037; PMCID: PMC2853759.
      260. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192; PMCID: PMC2669289.
      261. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. PMID: 18375757; PMCID: PMC2311365.
      262. McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P. Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence. Science. 2008 Mar 07; 319(5868):1405-8. PMID: 18323455; PMCID: PMC2288698.
      263. Buchanan JT, Colvin KM, Vicknair MR, Patel SK, Timmer AM, Nizet V. Strain-associated virulence factors of Streptococcus iniae in hybrid-striped bass. Vet Microbiol. 2008 Sep 18; 131(1-2):145-53. PMID: 18406547.
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      264. Peyssonnaux C, Boutin AT, Zinkernagel AS, Datta V, Nizet V, Johnson RS. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J Invest Dermatol. 2008 Aug; 128(8):1964-8. PMID: 18323789.
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      265. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br J Dermatol. 2008 Mar; 158(3):442-55. PMID: 18275522; PMCID: PMC2746716.
      266. Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science. 2008 Mar 07; 319(5868):1391-4. PMID: 18276850; PMCID: PMC2747771.
      267. Park B, Nizet V, Liu GY. Role of Staphylococcus aureus catalase in niche competition against Streptococcus pneumoniae. J Bacteriol. 2008 Apr; 190(7):2275-8. PMID: 18223076; PMCID: PMC2293205.
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      269. Maisey HC, Quach D, Hensler ME, Liu GY, Gallo RL, Nizet V, Doran KS. A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J. 2008 Jun; 22(6):1715-24. PMID: 18198218; PMCID: PMC2721339.
      270. Gillen CM, Courtney HS, Schulze K, Rohde M, Wilson MR, Timmer AM, Guzman CA, Nizet V, Chhatwal GS, Walker MJ. Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete. J Biol Chem. 2008 Mar 07; 283(10):6359-66. PMID: 18180300.
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      271. Peyssonnaux C, Nizet V, Johnson RS. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle. 2008 Jan 01; 7(1):28-32. PMID: 18212530.
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      272. Cole JN, Aquilina JA, Hains PG, Henningham A, Sriprakash KS, Caparon MG, Nizet V, Kotb M, Cordwell SJ, Djordjevic SP, Walker MJ. Role of group A Streptococcus HtrA in the maturation of SpeB protease. Proteomics. 2007 Dec; 7(24):4488-98. PMID: 18072207.
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      273. Zinkernagel AS, Johnson RS, Nizet V. Hypoxia inducible factor (HIF) function in innate immunity and infection. J Mol Med (Berl). 2007 Dec; 85(12):1339-46. PMID: 18030436.
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      274. Meluzzi D, Zheng WH, Hensler M, Nizet V, Dorrestein PC. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett. 2008 May 15; 18(10):3107-11. PMID: 18006314; PMCID: PMC2519147.
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      276. Lewis AL, Cao H, Patel SK, Diaz S, Ryan W, Carlin AF, Thon V, Lewis WG, Varki A, Chen X, Nizet V. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in group B Streptococcus. J Biol Chem. 2007 Sep 21; 282(38):27562-71. PMID: 17646166; PMCID: PMC2588433.
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      278. Bayele HK, Peyssonnaux C, Giatromanolaki A, Arrais-Silva WW, Mohamed HS, Collins H, Giorgio S, Koukourakis M, Johnson RS, Blackwell JM, Nizet V, Srai SK. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007 Oct 15; 110(8):3039-48. PMID: 17606764.
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      279. Nizet V. Understanding how leading bacterial pathogens subvert innate immunity to reveal novel therapeutic targets. J Allergy Clin Immunol. 2007 Jul; 120(1):13-22. PMID: 17606031.
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      282. Locke JB, Colvin KM, Varki N, Vicknair MR, Nizet V, Buchanan JT. Streptococcus iniae beta-hemolysin streptolysin S is a virulence factor in fish infection. Dis Aquat Organ. 2007 Jun 07; 76(1):17-26. PMID: 17718161.
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      283. Zinkernagel AS, Nizet V. Staphylococcus aureus: a blemish on skin immunity. Cell Host Microbe. 2007 May 17; 1(3):161-2. PMID: 18005694.
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      284. Kwinn LA, Nizet V. How group A Streptococcus circumvents host phagocyte defenses. Future Microbiol. 2007 Feb; 2(1):75-84. PMID: 17661677.
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      285. Kristian SA, Timmer AM, Liu GY, Lauth X, Sal-Man N, Rosenfeld Y, Shai Y, Gallo RL, Nizet V. Impairment of innate immune killing mechanisms by bacteriostatic antibiotics. FASEB J. 2007 Apr; 21(4):1107-16. PMID: 17215486.
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      286. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, Nizet V, Insel PA, Junger WG. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006 Dec 15; 314(5806):1792-5. PMID: 17170310.
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      287. Kwinn LA, Khosravi A, Aziz RK, Timmer AM, Doran KS, Kotb M, Nizet V. Genetic characterization and virulence role of the RALP3/LSA locus upstream of the streptolysin s operon in invasive M1T1 Group A Streptococcus. J Bacteriol. 2007 Feb; 189(4):1322-9. PMID: 17114267; PMCID: PMC1797346.
      288. Locke JB, Colvin KM, Datta AK, Patel SK, Naidu NN, Neely MN, Nizet V, Buchanan JT. Streptococcus iniae capsule impairs phagocytic clearance and contributes to virulence in fish. J Bacteriol. 2007 Feb; 189(4):1279-87. PMID: 17098893; PMCID: PMC1797360.
      289. Hamilton A, Popham DL, Carl DJ, Lauth X, Nizet V, Jones AL. Penicillin-binding protein 1a promotes resistance of group B streptococcus to antimicrobial peptides. Infect Immun. 2006 Nov; 74(11):6179-87. PMID: 17057092; PMCID: PMC1695509.
      290. Dehority W, Uchiyama S, Khosravi A, Nizet V. Brain abscess caused by Streptococcus pyogenes in a previously healthy child. J Clin Microbiol. 2006 Dec; 44(12):4613-5. PMID: 17065264; PMCID: PMC1698393.
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      292. Carlin AF, Lewis AL, Varki A, Nizet V. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol. 2007 Feb; 189(4):1231-7. PMID: 16997964; PMCID: PMC1797352.
      293. Hidalgo-Grass C, Mishalian I, Dan-Goor M, Belotserkovsky I, Eran Y, Nizet V, Peled A, Hanski E. A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues. EMBO J. 2006 Oct 04; 25(19):4628-37. PMID: 16977314; PMCID: PMC1589981.
      294. Timmer AM, Kristian SA, Datta V, Jeng A, Gillen CM, Walker MJ, Beall B, Nizet V. Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence. Mol Microbiol. 2006 Oct; 62(1):15-25. PMID: 16942605.
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      295. Hensler ME, Bernstein G, Nizet V, Nefzi A. Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library. Bioorg Med Chem Lett. 2006 Oct 01; 16(19):5073-9. PMID: 16890437.
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      297. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35. PMID: 16497591.
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      298. Buchanan JT, Simpson AJ, Aziz RK, Liu GY, Kristian SA, Kotb M, Feramisco J, Nizet V. DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol. 2006 Feb 21; 16(4):396-400. PMID: 16488874.
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      299. Lewis AL, Hensler ME, Varki A, Nizet V. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 2006 Apr 21; 281(16):11186-92. PMID: 16490781.
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      302. Nizet V. Antimicrobial peptide resistance mechanisms of human bacterial pathogens. Curr Issues Mol Biol. 2006 Jan; 8(1):11-26. PMID: 16450883.
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      303. Kristian SA, Datta V, Weidenmaier C, Kansal R, Fedtke I, Peschel A, Gallo RL, Nizet V. D-alanylation of teichoic acids promotes group a streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion. J Bacteriol. 2005 Oct; 187(19):6719-25. PMID: 16166534; PMCID: PMC1251589.
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      305. Buchanan JT, Stannard JA, Lauth X, Ostland VE, Powell HC, Westerman ME, Nizet V. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development. Infect Immun. 2005 Oct; 73(10):6935-44. PMID: 16177373; PMCID: PMC1230984.
      306. Doran KS, Engelson EJ, Khosravi A, Maisey HC, Fedtke I, Equils O, Michelsen KS, Arditi M, Peschel A, Nizet V. Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J Clin Invest. 2005 Sep; 115(9):2499-507. PMID: 16138192; PMCID: PMC1193870.
      307. Georgel P, Crozat K, Lauth X, Makrantonaki E, Seltmann H, Sovath S, Hoebe K, Du X, Rutschmann S, Jiang Z, Bigby T, Nizet V, Zouboulis CC, Beutler B. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun. 2005 Aug; 73(8):4512-21. PMID: 16040962; PMCID: PMC1201198.
      308. Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastian JF, Fierer J, Nizet V. Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005 Jul 18; 202(2):209-15. PMID: 16009720; PMCID: PMC2213009.
      309. Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol. 2005 Jul; 125(1):9-13. PMID: 15982297.
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      310. Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis EA, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005 Jul; 115(7):1806-15. PMID: 16007254; PMCID: PMC1159132.
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      312. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. PMID: 15858576.
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      313. Hensler ME, Liu GY, Sobczak S, Benirschke K, Nizet V, Heldt GP. Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection. J Infect Dis. 2005 Apr 15; 191(8):1287-91. PMID: 15776375.
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      314. Lauth X, Babon JJ, Stannard JA, Singh S, Nizet V, Carlberg JM, Ostland VE, Pennington MW, Norton RS, Westerman ME. Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J Biol Chem. 2005 Mar 11; 280(10):9272-82. PMID: 15546886.
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      315. Doran KS, Nizet V. Molecular pathogenesis of neonatal group B streptococcal infection: no longer in its infancy. Mol Microbiol. 2004 Oct; 54(1):23-31. PMID: 15458402.
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      316. Liu GY, Doran KS, Lawrence T, Turkson N, Puliti M, Tissi L, Nizet V. Sword and shield: linked group B streptococcal beta-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14491-6. PMID: 15381763; PMCID: PMC521972.
      317. Lewis AL, Nizet V, Varki A. Discovery and characterization of sialic acid O-acetylation in group B Streptococcus. Proc Natl Acad Sci U S A. 2004 Jul 27; 101(30):11123-8. PMID: 15263085; PMCID: PMC503750.
      318. Liu GY, Nizet V. Extracellular virulence factors of group B Streptococci. Front Biosci. 2004 May 01; 9:1794-802. PMID: 14977587.
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      319. Bardan A, Nizet V, Gallo RL. Antimicrobial peptides and the skin. Expert Opin Biol Ther. 2004 Apr; 4(4):543-9. PMID: 15102603.
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      320. Hidalgo-Grass C, Dan-Goor M, Maly A, Eran Y, Kwinn LA, Nizet V, Ravins M, Jaffe J, Peyser A, Moses AE, Hanski E. Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet. 2004 Feb 28; 363(9410):696-703. PMID: 15001327.
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      321. Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M. Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol Microbiol. 2004 Jan; 51(1):123-34. PMID: 14651616.
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      322. Saitoh A, Beall B, Nizet V. Fulminant bacterial meningitis complicating sphenoid sinusitis. Pediatr Emerg Care. 2003 Dec; 19(6):415-7. PMID: 14676492.
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      323. Gallo RL, Nizet V. Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr Allergy Asthma Rep. 2003 Sep; 3(5):402-9. PMID: 12906776.
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      324. Doran KS, Liu GY, Nizet V. Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest. 2003 Sep; 112(5):736-44. PMID: 12952922; PMCID: PMC182187.
      325. Kristian SA, Lauth X, Nizet V, Goetz F, Neumeister B, Peschel A, Landmann R. Alanylation of teichoic acids protects Staphylococcus aureus against Toll-like receptor 2-dependent host defense in a mouse tissue cage infection model. J Infect Dis. 2003 Aug 01; 188(3):414-23. PMID: 12870123.
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      326. Zaiou M, Nizet V, Gallo RL. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol. 2003 May; 120(5):810-6. PMID: 12713586.
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      327. Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003 Mar 07; 112(5):645-57. PMID: 12628185; PMCID: PMC4480774.
      328. Jeng A, Sakota V, Li Z, Datta V, Beall B, Nizet V. Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX. J Bacteriol. 2003 Feb; 185(4):1208-17. PMID: 12562790; PMCID: PMC142848.
      329. Kansal RG, Nizet V, Jeng A, Chuang WJ, Kotb M. Selective modulation of superantigen-induced responses by streptococcal cysteine protease. J Infect Dis. 2003 Feb 01; 187(3):398-407. PMID: 12552423.
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      330. Nizet V, Gallo RL. Cathelicidins and innate defense against invasive bacterial infection. Scand J Infect Dis. 2003; 35(9):670-6. PMID: 14620153.
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      331. Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec; 10(12):575-80. PMID: 12564994.
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      332. Ring A, Depnering C, Pohl J, Nizet V, Shenep JL, Stremmel W. Synergistic action of nitric oxide release from murine macrophages caused by group B streptococcal cell wall and beta-hemolysin/cytolysin. J Infect Dis. 2002 Nov 15; 186(10):1518-21. PMID: 12404173.
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      333. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
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      334. Fuller JD, Camus AC, Duncan CL, Nizet V, Bast DJ, Thune RL, Low DE, De Azavedo JC. Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease. Infect Immun. 2002 Oct; 70(10):5730-9. PMID: 12228303; PMCID: PMC128303.
      335. Nizet V, Gallo RL. Surviving innate immunity. Trends Microbiol. 2002 Aug; 10(8):358-9. PMID: 12160630.
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      336. Doran KS, Benoit VM, Gertz RE, Beall B, Nizet V. Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis. J Perinatol. 2002 Jun; 22(4):326-30. PMID: 12032798.
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      337. Ring A, Braun JS, Pohl J, Nizet V, Stremmel W, Shenep JL. Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis. J Infect Dis. 2002 Jun 15; 185(12):1745-53. PMID: 12085320.
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      338. Humar D, Datta V, Bast DJ, Beall B, De Azavedo JC, Nizet V. Streptolysin S and necrotising infections produced by group G streptococcus. Lancet. 2002 Jan 12; 359(9301):124-9. PMID: 11809255.
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      339. Doran KS, Chang JC, Benoit VM, Eckmann L, Nizet V. Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis. 2002 Jan 15; 185(2):196-203. PMID: 11807693.
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      340. Henneke P, Takeuchi O, van Strijp JA, Guttormsen HK, Smith JA, Schromm AB, Espevik TA, Akira S, Nizet V, Kasper DL, Golenbock DT. Novel engagement of CD14 and multiple toll-like receptors by group B streptococci. J Immunol. 2001 Dec 15; 167(12):7069-76. PMID: 11739528.
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      341. Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15; 277(7):5030-9. PMID: 11739390.
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      342. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piraino J, Huttner K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 2001 Nov 22; 414(6862):454-7. PMID: 11719807.
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      343. Dorschner RA, Pestonjamasp VK, Tamakuwala S, Ohtake T, Rudisill J, Nizet V, Agerberth B, Gudmundsson GH, Gallo RL. Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol. 2001 Jul; 117(1):91-7. PMID: 11442754.
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      344. Ballon-Landa GR, Gherardi G, Beall B, Krosner S, Nizet V. Necrotizing fasciitis due to penicillin-resistant Streptococcus pneumoniae: case report and review of the literature. J Infect. 2001 May; 42(4):272-7. PMID: 11545571.
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      345. Fuller JD, Bast DJ, Nizet V, Low DE, de Azavedo JC. Streptococcus iniae virulence is associated with a distinct genetic profile. Infect Immun. 2001 Apr; 69(4):1994-2000. PMID: 11254550; PMCID: PMC98122.
      346. Pritzlaff CA, Chang JC, Kuo SP, Tamura GS, Rubens CE, Nizet V. Genetic basis for the beta-haemolytic/cytolytic activity of group B Streptococcus. Mol Microbiol. 2001 Jan; 39(2):236-47. PMID: 11136446.
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      347. Puliti M, Nizet V, von Hunolstein C, Bistoni F, Mosci P, Orefici G, Tissi L. Severity of group B streptococcal arthritis is correlated with beta-hemolysin expression. J Infect Dis. 2000 Sep; 182(3):824-32. PMID: 10950777.
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      348. Nizet V, Beall B, Bast DJ, Datta V, Kilburn L, Low DE, De Azavedo JC. Genetic locus for streptolysin S production by group A streptococcus. Infect Immun. 2000 Jul; 68(7):4245-54. PMID: 10858242; PMCID: PMC101736.
      349. Ring A, Braun JS, Nizet V, Stremmel W, Shenep JL. Group B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages. J Infect Dis. 2000 Jul; 182(1):150-7. PMID: 10882592.
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      350. Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun. 2000 Feb; 68(2):637-43. PMID: 10639427; PMCID: PMC97186.
      351. Gibson RL, Nizet V, Rubens CE. Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells. Pediatr Res. 1999 May; 45(5 Pt 1):626-34. PMID: 10231855.
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      352. Nizet V, Kim KS, Stins M, Jonas M, Chi EY, Nguyen D, Rubens CE. Invasion of brain microvascular endothelial cells by group B streptococci. Infect Immun. 1997 Dec; 65(12):5074-81. PMID: 9393798; PMCID: PMC175731.
      353. La Penta D, Framson P, Nizet V, Rubens C. Epithelial cell invasion by group B streptococci is important to virulence. Adv Exp Med Biol. 1997; 418:631-4. PMID: 9331731.
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      354. Nizet V, Gibson RL, Rubens CE. The role of group B streptococci beta-hemolysin expression in newborn lung injury. Adv Exp Med Biol. 1997; 418:627-30. PMID: 9331730.
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      355. Nizet V, Gibson RL, Chi EY, Framson PE, Hulse M, Rubens CE. Group B streptococcal beta-hemolysin expression is associated with injury of lung epithelial cells. Infect Immun. 1996 Sep; 64(9):3818-26. PMID: 8751934; PMCID: PMC174298.
      356. Mills WJ, Mosca VS, Nizet V. Orthopaedic manifestations of invasive group A streptococcal infections complicating primary varicella. J Pediatr Orthop. 1996 Jul-Aug; 16(4):522-8. PMID: 8784712.
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      357. Brogan TV, Nizet V, Waldhausen JH. Streptococcal skin infections. N Engl J Med. 1996 May 30; 334(22):1478. PMID: 8618597.
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      358. Nizet V, Colina KF, Almquist JR, Rubens CE, Smith AL. A virulent nonencapsulated Haemophilus influenzae. J Infect Dis. 1996 Jan; 173(1):180-6. PMID: 8537657.
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      359. Brogan TV, Nizet V, Waldhausen JH, Rubens CE, Clarke WR. Group A streptococcal necrotizing fasciitis complicating primary varicella: a series of fourteen patients. Pediatr Infect Dis J. 1995 Jul; 14(7):588-94. PMID: 7567287.
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      360. Nizet V, Priebe CJ. A newborn girl with watery diarrhea, weight loss, and severe metabolic acidosis. Curr Opin Pediatr. 1994 Apr; 6(2):163-7. PMID: 8032396.
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      361. Nizet V, Vinci RJ, Lovejoy FH. Fever in children. Pediatr Rev. 1994 Apr; 15(4):127-35. PMID: 8015996.
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      362. Priebe CJ, Nizet V. A 5-year-old girl with varicella and acute onset of fever, stridor, and respiratory distress. Curr Opin Pediatr. 1994 Feb; 6(1):36-41. PMID: 8205172.
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      363. Priebe CJ, Nizet V. A 7-month-old boy with poor growth, hypercalcemia, and unusual facies. Curr Opin Pediatr. 1993 Dec; 5(6):728-32. PMID: 8124427.
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      364. Priebe CJ, Nizet V. A 2-year-old girl with hematemesis, melena, and splenomegaly. Curr Opin Pediatr. 1993 Oct; 5(5):590-4. PMID: 8287083.
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      365. Lovejoy FH, Nizet V, Priebe CJ. Common etiologies and new approaches to management of poisoning in pediatric practice. Curr Opin Pediatr. 1993 Oct; 5(5):524-30. PMID: 8287075.
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      366. Nizet V, Priebe CJ. An 8-day-old male infant with poor feeding, lethargy, and an elevated anion gap metabolic acidosis. Curr Opin Pediatr. 1993 Aug; 5(4):499-502. PMID: 8374680.
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      367. Palefsky JM, Winkler B, Rabanus JP, Clark C, Chan S, Nizet V, Schoolnik GK. Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues. J Clin Invest. 1991 Jun; 87(6):2132-41. PMID: 1645754; PMCID: PMC296971.
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