Lee Hagey

Title(s)Project Sci , Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    1. The changing metabolic landscape of bile acids - keys to metabolism and immune regulation. Nat Rev Gastroenterol Hepatol. 2024 Apr 04. Mohanty I, Allaband C, Mannochio-Russo H, El Abiead Y, Hagey LR, Knight R, Dorrestein PC. PMID: 38575682.
      View in: PubMed   Mentions:    Fields:    
    2. The underappreciated diversity of bile acid modifications. Cell. 2024 Mar 06. Mohanty I, Mannochio-Russo H, Schweer JV, El Abiead Y, Bittremieux W, Xing S, Schmid R, Zuffa S, Vasquez F, Muti VB, Zemlin J, Tovar-Herrera OE, Moraïs S, Desai D, Amin S, Koo I, Turck CW, Mizrahi I, Kris-Etherton PM, Petersen KS, Fleming JA, Huan T, Patterson AD, Siegel D, Hagey LR, Wang M, Aron AT, Dorrestein PC. PMID: 38471500.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems. Anal Chem. 2023 10 17; 95(41):15357-15366. Stewart AK, Foley MH, Dougherty MK, McGill SK, Gulati AS, Gentry EC, Hagey LR, Dorrestein PC, Theriot CM, Dodds JN, Baker ES. PMID: 37796494; PMCID: PMC10613829.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Insulin Prevents Hypercholesterolemia by Suppressing 12α-Hydroxylated Bile Acids. Circulation. 2022 03 29; 145(13):969-982. Semova I, Levenson AE, Krawczyk J, Bullock K, Gearing ME, Ling AV, Williams KA, Miao J, Adamson SS, Shin DJ, Chahar S, Graham MJ, Crooke RM, Hagey LR, Vicent D, de Ferranti SD, Kidambi S, Clish CB, Biddinger SB. PMID: 35193378; PMCID: PMC9365453.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    5. Evolutionary Analysis of Bile Acid-Conjugating Enzymes Reveals a Complex Duplication and Reciprocal Loss History. Genome Biol Evol. 2019 11 01; 11(11):3256-3268. Kirilenko BM, Hagey LR, Barnes S, Falany CN, Hiller M. PMID: 31670760; PMCID: PMC6934887.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    6. Bile Acids and the Microbiome in the Cow: Lack of Deoxycholic Acid Hydroxylation. Lipids. 2018 03; 53(3):269-270. Hofmann AF, Herdt T, Ames NK, Chen Z, Hagey LR. PMID: 29668048.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Identification and characterization of 5α-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). J Steroid Biochem Mol Biol. 2017 11; 174:120-127. Kurogi K, Yoshihama M, Horton A, Schiefer IT, Krasowski MD, Hagey LR, Williams FE, Sakakibara Y, Kenmochi N, Suiko M, Liu MC. PMID: 28807679; PMCID: PMC5675747.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    8. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology. 2016 12; 64(6):2151-2164. Kulkarni SR, Soroka CJ, Hagey LR, Boyer JL. PMID: 27639250; PMCID: PMC5115990.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    9. Two Major Bile Acids in the Hornbills, (24R,25S)-3α,7α,24-Trihydroxy-5β-cholestan-27-oyl Taurine and Its 12α-Hydroxy Derivative. Lipids. 2016 06; 51(6):757-68. Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T. PMID: 27108034.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Novel, major 2α- and 2β-hydroxy bile alcohols and bile acids in the bile of Arapaima gigas, a large South American river fish. Steroids. 2016 Mar; 107:112-20. Sato née Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Raines J, Hagey LR, Hofmann AF, Iida T. PMID: 26768415.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 62(4):1227-36. Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. PMID: 26108984; PMCID: PMC4589453.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    12. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology. 2016 Jan; 63(1):185-96. Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey LR, LaRusso NF. PMID: 26044703; PMCID: PMC4670294.
      View in: PubMed   Mentions: 92     Fields:    Translation:Animals
    13. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 03; 21(2):298-311. de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. PMID: 25651182; PMCID: PMC4317590.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    14. Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): nine cases and pathogenesis of stone formation. J Zoo Wildl Med. 2014 Dec; 45(4):883-91. Spriggs M, Thompson KA, Barton D, Talley J, Volle K, Stasiak I, Beyea L, Guthrie A, Roda A, Camborata C, Hofmann AF, Hagey LR. PMID: 25632677.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    15. Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile acids. Lipids. 2014 Nov; 49(11):1169-80. Omura K, Ohsaki A, Zhou B, Kushida M, Mitsuma T, Kobayashi A, Hagey LR, Hofmann AF, Iida T. PMID: 25319478.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res. 2014 Aug; 55(8):1553-95. Hofmann AF, Hagey LR. PMID: 24838141; PMCID: PMC4109754.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    17. N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish. Steroids. 2014 Feb; 80:15-23. Satoh Née Okihara R, Saito T, Ogata H, Ohsaki A, Iida T, Asahina K, Mitamura K, Ikegawa S, Hofmann AF, Hagey LR. PMID: 24291417.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Altered lipid metabolism in gastroschisis: a novel hypothesis. Am J Med Genet A. 2013 Aug; 161A(8):1860-5. Jones KL, Jones KL, Weiss LA, Hagey LR, Gonzalez V, Benirschke K, Chambers CD. PMID: 23794282.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G286-94. Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey LR, Ling V. PMID: 23764895.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    20. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun; 57(6):2418-26. Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. PMID: 23175353; PMCID: PMC3604052.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    21. An efficient synthesis of 7α,12α-dihydroxy-4-cholesten-3-one and its biological precursor 7α-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. Steroids. 2013 Sep; 78(9):927-37. Ogawa S, Zhou B, Kimoto Y, Omura K, Kobayashi A, Higashi T, Mitamura K, Ikegawa S, Hagey LR, Hofmann AF, Iida T. PMID: 23707572.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice. PLoS One. 2013; 8(3):e60270. Kuo SM, Merhige PM, Hagey LR. PMID: 23555939; PMCID: PMC3605333.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    23. Microbial biotransformations of bile acids as detected by electrospray mass spectrometry. Adv Nutr. 2013 Jan 01; 4(1):29-35. Hagey LR, Krasowski MD. PMID: 23319120; PMCID: PMC3648736.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    24. A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among related species. Cell Rep. 2012 Oct 25; 2(4):817-23. Hiller M, Schaar BT, Indjeian VB, Kingsley DM, Hagey LR, Bejerano G. PMID: 23022484; PMCID: PMC3572205.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimals
    25. A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids. 2012 Nov; 77(13):1510-21. Hagey LR, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T. PMID: 22986074.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    26. Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 01; 900:24-31. Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann AF, Hagey LR, Nittono H. PMID: 22695323.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    27. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 01; 302(9):G925-36. Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. PMID: 22345550; PMCID: PMC3362073.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    28. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. Am J Med Genet A. 2012 Apr; 158A(4):803-7. Weiss LA, Chambers CD, Gonzalez V, Hagey LR, Jones KL, Jones KL. PMID: 22315197.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid. Steroids. 2011 Sep-Oct; 76(10-11):1126-35. Hagey LR, Iida T, Ogawa S, Adachi Y, Une M, Mushiake K, Maekawa M, Shimada M, Mano N, Hofmann AF. PMID: 21600907.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates. Chem Phys Lipids. 2011 Jul; 164(5):368-77. Ogawa S, Mitamura K, Ikegawa S, Krasowski MD, Hagey LR, Hofmann AF, Iida T. PMID: 21554864.
      View in: PubMed   Mentions: 2     Fields:    
    31. The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC Biochem. 2011 Feb 03; 12:5. Krasowski MD, Ai N, Hagey LR, Kollitz EM, Kullman SW, Reschly EJ, Ekins S. PMID: 21291553; PMCID: PMC3042382.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. COMPLEX EVOLUTION OF BILE SALTS IN BIRDS. Auk. 2010 Oct; 127(4):820-831. Hagey LR, Vidal N, Hofmann AF, Krasowski MD. PMID: 21113274; PMCID: PMC2990222.
      View in: PubMed   Mentions: 9  
    33. Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol. 2011 Mar 01; 334(1-2):39-48. Krasowski MD, Ni A, Hagey LR, Ekins S. PMID: 20615451; PMCID: PMC3033471.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    34. Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. Zoolog Sci. 2010 Jul; 27(7):565-73. Hagey LR, Lida T, Tamegai H, Ogawa S, Une M, Asahina K, Mushiake K, Goto T, Mano N, Goto J, Krasowski MD, Hofmann AF. PMID: 20608845; PMCID: PMC2901895.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    35. Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol. 2010 May 06; 10:133. Hagey LR, Vidal N, Hofmann AF, Krasowski MD. PMID: 20444292; PMCID: PMC2886068.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    36. Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol. 2010 Jul 01; 98(3):245-255. Howarth DL, Hagey LR, Law SHW, Ai N, Krasowski MD, Ekins S, Moore JT, Kollitz EM, Hinton DE, Kullman SW. PMID: 20430454; PMCID: PMC2874645.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool. 2010 Mar-Apr; 83(2):308-21. Hagey LR, Møller PR, Hofmann AF, Krasowski MD. PMID: 20113173; PMCID: PMC2845723.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    38. Olfactory sensitivity to bile fluid and bile salts in the European eel (Anguilla anguilla), goldfish (Carassius auratus) and Mozambique tilapia (Oreochromis mossambicus) suggests a 'broad range' sensitivity not confined to those produced by conspecifics alone. J Exp Biol. 2010 Jan 15; 213(2):308-17. Huertas M, Hagey L, Hofmann AF, Cerdà J, Canário AV, Hubbard PC. PMID: 20038666.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    39. Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 2010 Jan; 51(1):181-90. Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL. PMID: 19902485; PMCID: PMC2819820.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    40. Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res. 2010 Feb; 51(2):226-46. Hofmann AF, Hagey LR, Krasowski MD. PMID: 19638645; PMCID: PMC2803226.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimals
    41. Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. Pancreas. 2009 Mar; 38(2):232-3. Money ME, Hofmann AF, Hagey LR, Walkowiak J, Talley NJ. PMID: 19238028.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid. J Lipid Res. 2009 Apr; 50(4):651-7. Hagey LR, Kakiyama G, Muto A, Iida T, Mushiake K, Goto T, Mano N, Goto J, Oliveira CA, Hofmann AF. PMID: 19011113; PMCID: PMC2656658.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    43. Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):598-606. Hofmann AF, Loening-Baucke V, Lavine JE, Hagey LR, Steinbach JH, Packard CA, Griffin TL, Chatfield DA. PMID: 18955863.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    44. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008 Aug; 65(16):2461-83. Hofmann AF, Hagey LR. PMID: 18488143.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansAnimals
    45. Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol Biol. 2008 Apr 02; 8:103. Ekins S, Reschly EJ, Hagey LR, Krasowski MD. PMID: 18384689; PMCID: PMC2358886.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    46. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res. 2008 Jul; 49(7):1577-87. Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey LR, Hofmann AF, Krasowski MD. PMID: 18362391; PMCID: PMC2431107.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    47. Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol. 2008 May; 110(1-2):83-94. Reschly EJ, Ai N, Welsh WJ, Ekins S, Hagey LR, Krasowski MD. PMID: 18395439; PMCID: PMC2519238.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    48. Sex, age, and family differences in the chemical composition of owl monkey (Aotus nancymaae) subcaudal scent secretions. Am J Primatol. 2008 Jan; 70(1):12-8. Macdonald EA, Fernandez-Duque E, Evans S, Hagey LR. PMID: 17577212.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    49. Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol. 2007 Nov 12; 7:222. Reschly EJ, Bainy AC, Mattos JJ, Hagey LR, Bahary N, Mada SR, Ou J, Venkataramanan R, Krasowski MD. PMID: 17997857; PMCID: PMC2263054.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    50. Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid. J Lipid Res. 2007 Dec; 48(12):2682-92. Kakiyama G, Tamegai H, Iida T, Mitamura K, Ikegawa S, Goto T, Mano N, Goto J, Holz P, Hagey LR, Hofmann AF. PMID: 17785716.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    51. Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G256-63. Hamilton JP, Xie G, Raufman JP, Hogan S, Griffin TL, Packard CA, Chatfield DA, Hagey LR, Steinbach JH, Hofmann AF. PMID: 17412828.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    52. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. Keely SJ, Scharl MM, Bertelsen LS, Hagey LR, Barrett KE, Hofmann AF. PMID: 16901996.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    53. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. J Lipid Res. 2006 Sep; 47(9):2020-7. Sehayek E, Hagey LR, Fung YY, Duncan EM, Yu HJ, Eggertsen G, Björkhem I, Hofmann AF, Breslow JL. PMID: 16763287.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    54. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May; 43(5):1013-21. Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. PMID: 16628672.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    55. Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid. J Lipid Res. 2006 Jul; 47(7):1551-8. Kakiyama G, Iida T, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Schteingart CD, Hofmann AF. PMID: 16648547.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    56. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology. 2005 Dec; 42(6):1391-8. Hofmann AF, Zakko SF, Lira M, Clerici C, Hagey LR, Lambert KK, Steinbach JH, Schteingart CD, Olinga P, Groothuis GM. PMID: 16317695.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    57. The elephants of Zoba Gash Barka, Eritrea: part 4. Cholelithiasis in a wild African elephant (Loxodonta africana). J Zoo Wildl Med. 2005 Dec; 36(4):677-83. Agnew DW, Hagey L, Shoshani J. PMID: 17312726.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    58. Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept. 2005 Sep 30; 3:2. Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. PMID: 16197547; PMCID: PMC1262763.
      View in: PubMed   Mentions: 40  
    59. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res. 2005 Oct; 46(10):2221-32. Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF. PMID: 16061950.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    60. Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol. 2005 Jul; 19(7):1720-39. Krasowski MD, Yasuda K, Hagey LR, Schuetz EG. PMID: 15718292; PMCID: PMC2238640.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    61. Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat. J Lipid Res. 2004 Mar; 45(3):567-73. Kakiyama G, Iida T, Yoshimoto A, Goto T, Mano N, Goto J, Nambara T, Hagey LR, Hofmann AF. PMID: 14657194.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish. J Lipid Res. 2003 Sep; 44(9):1643-51. Goto T, Holzinger F, Hagey LR, Cerrè C, Ton-Nu HT, Schteingart CD, Steinbach JH, Shneider BL, Hofmann AF. PMID: 12810826.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    63. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med. 2003 Jun; 141(6):411-8. Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey LR, Macdonald EA, Hofmann AF. PMID: 12819639.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    64. Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca). J Chem Ecol. 2003 Jun; 29(6):1479-88. Hagey L, MacDonald E. PMID: 12918929.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    65. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology. 2003 Mar; 37(3):551-7. Lorenzo-Zúñiga V, Bartolí R, Planas R, Hofmann AF, Viñado B, Hagey LR, Hernández JM, Mañé J, Alvarez MA, Ausina V, Gassull MA. PMID: 12601352.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    66. The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease. Liver Int. 2003; 23 Suppl 3:34-8. Zeh N, Rossi SS, Hofmann AF, Steinbach JH, Hagey LR, Oliver D, Stange J, Hassanein T. PMID: 12950959.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    67. Comparative urinary androstanes in the great apes. Gen Comp Endocrinol. 2003 Jan; 130(1):64-9. Hagey LR, Czekala NM. PMID: 12535626.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    68. Identification of a series of C(21)O(2) pregnanes from fecal extracts of a pregnant black rhinoceros (Diceros bicornis minor). Steroids. 2001 Dec; 66(12):875-81. Lance VA, Patton ML, Hagey LR. PMID: 11711115.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    69. Bile acid absorption after near-total proctocolectomy in dogs: ileal pouch vs. jejunal pouch-distal rectal anastomosis. J Gastrointest Surg. 2001 Sep-Oct; 5(5):540-5. Teixeira FV, Hofmann AF, Hagey LR, Pera M, Kelly KA. PMID: 11986006.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    70. Monitoring hormones in urine and feces of captive bonobos (Pan paniscus). Primates. 2000 Jul; 41(3):311-319. Jurke MH, Hagey LR, Jurke S, Czekala NM. PMID: 30545182.
      View in: PubMed   Mentions: 5     Fields:    
    71. Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats. Gastroenterology. 1999 Oct; 117(4):962-71. Bolder U, Trang NV, Hagey LR, Schteingart CD, Ton-Nu HT, Cerrè C, Elferink RP, Hofmann AF. PMID: 10500080.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    72. Nanoelectrospray mass spectrometry and precursor ion monitoring for quantitative steroid analysis and attomole sensitivity. Anal Chem. 1999 Jul 01; 71(13):2358-63. Chatman K, Hollenbeck T, Hagey L, Vallee M, Purdy R, Weiss F, Siuzdak G. PMID: 10405603.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    73. Conjugated bile acid replacement therapy for short-bowel syndrome. Gastroenterology. 1999 Jan; 116(1):15-21. Gruy-Kapral C, Little KH, Fordtran JS, Meziere TL, Hagey LR, Hofmann AF. PMID: 9869597.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    74. An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit. J Lipid Res. 1998 Nov; 39(11):2119-24. Hagey LR, Schteingart CD, Rossi SS, Ton-Nu HT, Hofmann AF. PMID: 9799797.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    75. Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis. Dig Dis Sci. 1998 Jun; 43(6):1292-5. Ricci P, Hofmann AF, Hagey LR, Jorgensen RA, Rolland Dickson E, Lindor KD. PMID: 9635620.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    76. Monitoring pregnancy in twinning pygmy loris (Nycticebus pygmaeus) using fecal estrogen metabolites. Am J Primatol. 1998; 46(2):173-83. Jurke MH, Czekala NM, Jurke S, Hagey LR, Lance VA, Conley AJ, Fitch-Snyder H. PMID: 9773680.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    77. Fluorescent bile acid derivatives: relationship between chemical structure and hepatic and intestinal transport in the rat. Hepatology. 1997 Nov; 26(5):1263-71. Holzinger F, Schteingart CD, Ton-Nu HT, Eming SA, Monte MJ, Hagey LR, Hofmann AF. PMID: 9362371.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    78. Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid. Hepatology. 1997 Aug; 26(2):374-85. Yeh HZ, Schteingart CD, Hagey LR, Ton-Nu HT, Bolder U, Gavrilkina MA, Steinbach JH, Hofmann AF. PMID: 9252148.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    79. An improved method for the measurement of lidocaine and its metabolites in rat plasma. Ther Drug Monit. 1997 Apr; 19(2):179-84. Rossi SS, Moore AC, Hagey LR, Yaksh TL, Chaplan SR. PMID: 9108647.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    80. Hepatic biotransformation in rodents and physicochemical properties of 23(R)-hydroxychenodeoxycholic acid, a natural alpha-hydroxy bile acid. J Lipid Res. 1996 Jan; 37(1):98-112. Merrill JR, Schteingart CD, Hagey LR, Peng Y, Ton-Nu HT, Frick E, Jirsa M, Hofmann AF. PMID: 8820106.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    81. Biliary bile acids of fruit pigeons and doves (Columbiformes): presence of 1-beta-hydroxychenodeoxycholic acid and conjugation with glycine as well as taurine. J Lipid Res. 1994 Nov; 35(11):2041-8. Hagey LR, Schteingart CD, Ton-Nu HT, Hofmann AF. PMID: 7868982.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    82. Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores. J Lipid Res. 1993 Nov; 34(11):1911-7. Hagey LR, Crombie DL, Espinosa E, Carey MC, Igimi H, Hofmann AF. PMID: 8263415.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    83. Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J Biol Chem. 1993 Jul 05; 268(19):13987-93. Stravitz RT, Hylemon PB, Heuman DM, Hagey LR, Schteingart CD, Ton-Nu HT, Hofmann AF, Vlahcevic ZR. PMID: 8314765.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    84. 5 beta-hydroxylation by the liver. Identification of 3,5,7-trihydroxy nor-bile acids as new major biotransformation products of 3,7-dihydroxy nor-bile acids in rodents. J Biol Chem. 1993 May 25; 268(15):11239-46. Schteingart CD, Hagey LR, Setchell KD, Hofmann AF. PMID: 8496179.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    85. Negative feedback regulation of the ileal bile acid transport system in rodents. Gastroenterology. 1993 Jan; 104(1):38-46. Lillienau J, Crombie DL, Munoz J, Longmire-Cook SJ, Hagey LR, Hofmann AF. PMID: 8419260.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    86. Hepatic and ileal transport and effect on biliary secretion of norursocholic acid and its conjugates in rats. Am J Physiol. 1991 Dec; 261(6 Pt 1):G1057-64. Lillienau J, Hagey LR, Borgström B. PMID: 1767847.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    87. Chemical synthesis and hepatic biotransformation of 3 alpha,7 alpha-dihydroxy-7 beta-methyl-24-nor-5 beta-cholan-23-oic acid, a 7-methyl derivative of norchenodeoxycholic acid: studies in the hamster. J Lipid Res. 1991 Nov; 32(11):1729-40. Yoshii M, Mosbach EH, Schteingart CD, Hagey LR, Hofmann AF, Cohen BI, McSherry CK. PMID: 1770293.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    88. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. Hepatology. 1991 Mar; 13(3):540-50. Gurantz D, Schteingart CD, Hagey LR, Steinbach JH, Grotmol T, Hofmann AF. PMID: 1999323.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    89. Transport, metabolism, and effect of chronic feeding of lagodeoxycholic acid. A new, natural bile acid. Gastroenterology. 1990 Oct; 99(4):1092-104. Schmassmann A, Angellotti MA, Clerici C, Hofmann AF, Ton-Nu HT, Schteingart CD, Marcus SN, Hagey LR, Rossi SS, Aigner A. PMID: 2394330.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    90. Biliary bile acid profiles of domestic fowl as determined by high performance liquid chromatography and fast atom bombardment mass spectrometry. Comp Biochem Physiol B. 1990; 96(1):157-61. Elkin RG, Wood KV, Hagey LR. PMID: 2364668.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    91. Selective hepatobiliary transport of nordeoxycholate side chain conjugates in mutant rats with a canalicular transport defect. Hepatology. 1989 Jun; 9(6):861-5. Oude Elferink RP, de Haan J, Lambert KJ, Hagey LR, Hofmann AF, Jansen PL. PMID: 2714736.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    92. Role of bile acid conjugation in hepatic transport of dihydroxy bile acids. J Pharmacol Exp Ther. 1989 Mar; 248(3):1130-7. Clayton LM, Gurantz D, Hofmann AF, Hagey LR, Schteingart CD. PMID: 2703966.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    93. Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated urodeoxycholate, and increased ursodeoxycholate glucuronidation. Gastroenterology. 1988 Aug; 95(2):454-63. Lake JR, Renner EL, Scharschmidt BF, Cragoe EJ, Hagey LR, Lambert KJ, Gurantz D, Hofmann AF. PMID: 2455672.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    94. Bile salts of the West Indian manatee, Trichechus manatus latirostris: novel bile alcohol sulfates and absence of bile acids. J Lipid Res. 1988 Apr; 29(4):509-22. Kuroki S, Schteingart CD, Hagey LR, Cohen BI, Mosbach EH, Rossi SS, Hofmann AF, Matoba N, Une M, Hoshita T, et al. PMID: 3392467.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    95. Effect of side chain length on bile acid conjugation: glucuronidation, sulfation and coenzyme A formation of nor-bile acids and their natural C24 homologs by human and rat liver fractions. Hepatology. 1988 Mar-Apr; 8(2):353-7. Kirkpatrick RB, Green MD, Hagey LR, Hofmann AF, Tephly TR. PMID: 3356416.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    96. Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent. Am J Physiol. 1987 Feb; 252(2 Pt 1):G219-28. Palmer KR, Gurantz D, Hofmann AF, Clayton LM, Hagey LR, Cecchetti S. PMID: 3826349.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    97. Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit. Gastroenterology. 1986 Jul; 91(1):189-97. Cohen BI, Hofmann AF, Mosbach EH, Stenger RJ, Rothschild MA, Hagey LR, Yoon YB. PMID: 3710068.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    98. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology. 1986 Apr; 90(4):837-52. Yoon YB, Hagey LR, Hofmann AF, Gurantz D, Michelotti EL, Steinbach JH. PMID: 3949115.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
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