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Christopher Benner

Title(s)Assistant Professor In Residence, Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0640
La Jolla CA 92093
Phone858-534-9449
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Diego, La JollaPhD01/2009Bioinformatics
    University of California, San Diego , La JollaBS06/2002Bioengineering

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Uncovering how transcription and chromatin 3D structure impact one another during cellular activation
    NIH/NIGMS R01GM134366Sep 16, 2019 - Jun 30, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. Cell. 2020 Jun 17. Ho JSY, Angel M, Ma Y, Sloan E, Wang G, Martinez-Romero C, Alenquer M, Roudko V, Chung L, Zheng S, Chang M, Fstkchyan Y, Clohisey S, Dinan AM, Gibbs J, Gifford R, Shen R, Gu Q, Irigoyen N, Campisi L, Huang C, Zhao N, Jones JD, van Knippenberg I, Zhu Z, Moshkina N, Meyer L, Noel J, Peralta Z, Rezelj V, Kaake R, Rosenberg B, Wang B, Wei J, Paessler S, Wise HM, Johnson J, Vannini A, Amorim MJ, Baillie JK, Miraldi ER, Benner C, Brierley I, Digard P, Luksza M, Firth AE, Krogan N, Greenbaum BD, MacLeod MK, van Bakel H, Garcìa-Sastre A, Yewdell JW, Hutchinson E, Marazzi I. PMID: 32559462.
      View in: PubMed   Mentions:    Fields:    
    2. A genome-wide CRISPR-Cas9 screen reveals the requirement of host cell sulfation for Schmallenberg virus infection. J Virol. 2020 Jun 10. Thamamongood T, Aebischer A, Wagner V, Chang MW, Elling R, Benner C, García-Sastre A, Kochs G, Beer M, Schwemmle M. PMID: 32522852.
      View in: PubMed   Mentions:    Fields:    
    3. ARTDeco: automatic readthrough transcription detection. BMC Bioinformatics. 2020 May 26; 21(1):214. Roth SJ, Heinz S, Benner C. PMID: 32456667.
      View in: PubMed   Mentions:    Fields:    
    4. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development. Nat Commun. 2020 Apr 29; 11(1):2082. Vinckier NK, Patel NA, Geusz RJ, Wang A, Wang J, Matta I, Harrington AR, Wortham M, Wetton N, Wang J, Jhala US, Rosenfeld MG, Benner CW, Shih HP, Sander M. PMID: 32350257.
      View in: PubMed   Mentions:    Fields:    
    5. A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17. Riva L, Yuan S, Yin X, Martin-Sancho L, Matsunaga N, Burgstaller-Muehlbacher S, Pache L, De Jesus PP, Hull MV, Chang M, Chan JF, Cao J, Poon VK, Herbert K, Nguyen TT, Pu Y, Nguyen C, Rubanov A, Martinez-Sobrido L, Liu WC, Miorin L, White KM, Johnson JR, Benner C, Sun R, Schultz PG, Su A, Garcia-Sastre A, Chatterjee AK, Yuen KY, Chanda SK. PMID: 32511357.
      View in: PubMed   Mentions:
    6. ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis. Proc Natl Acad Sci U S A. 2020 Apr 28; 117(17):9311-9317. Weiss RJ, Spahn PN, Toledo AG, Chiang AWT, Kellman BP, Li J, Benner C, Glass CK, Gordts PLSM, Lewis NE, Esko JD. PMID: 32277030.
      View in: PubMed   Mentions:    Fields:    
    7. NCoR1 Protects Mice From Dextran Sodium Sulfate-Induced Colitis by Guarding Colonic Crypt Cells From Luminal Insult. Cell Mol Gastroenterol Hepatol. 2020; 10(1):133-147. Mennillo E, Yang X, Paszek M, Auwerx J, Benner C, Chen S. PMID: 32044398.
      View in: PubMed   Mentions:    Fields:    
    8. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626. Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 32258954.
      View in: PubMed   Mentions:
    9. Viral Determinants in H5N1 Influenza A Virus Enable Productive Infection of HeLa Cells. J Virol. 2020 Jan 31; 94(4). Rodriguez-Frandsen A, Martin-Sancho L, Gounder AP, Chang MW, Liu WC, De Jesus PD, von Recum-Knepper J, Dutra MS, Huffmaster NJ, Chavarria M, Mena I, Riva L, Nguyen CB, Dobariya S, Herbert KM, Benner C, Albrecht RA, García-Sastre A, Chanda SK. PMID: 31776276.
      View in: PubMed   Mentions:    Fields:    
    10. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Gastroenterology. 2020 May; 158(6):1728-1744.e14. Liu X, Xu J, Rosenthal S, Zhang LJ, McCubbin R, Meshgin N, Shang L, Koyama Y, Ma HY, Sharma S, Heinz S, Glass CK, Benner C, Brenner DA, Kisseleva T. PMID: 31982409.
      View in: PubMed   Mentions: 1     Fields:    
    11. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions:    Fields:    
    12. Identification and dynamic quantification of regulatory elements using total RNA. Genome Res. 2019 11; 29(11):1836-1846. Duttke SH, Chang MW, Heinz S, Benner C. PMID: 31649059.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers. Cell. 2019 10 03; 179(2):373-391.e27. Brigidi GS, Hayes MGB, Delos Santos NP, Hartzell AL, Texari L, Lin PA, Bartlett A, Ecker JR, Benner C, Heinz S, Bloodgood BL. PMID: 31585079.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Paradoxical association of TET loss of function with genome-wide DNA hypomethylation. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):16933-16942. López-Moyado IF, Tsagaratou A, Yuita H, Seo H, Delatte B, Heinz S, Benner C, Rao A. PMID: 31371502.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395. Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690.
      View in: PubMed   Mentions: 2     Fields:    
    16. Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway. Protein Cell. 2019 07; 10(7):485-495. Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC. PMID: 31041783.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019 04 03; 10(1):1523. Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. PMID: 30944313.
      View in: PubMed   Mentions: 51     Fields:    
    18. Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome. Elife. 2019 03 06; 8. Wegner M, Diehl V, Bittl V, de Bruyn R, Wiechmann S, Matthess Y, Hebel M, Hayes MG, Schaubeck S, Benner C, Heinz S, Bremm A, Dikic I, Ernst A, Kaulich M. PMID: 30838976.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. MHC class II proteins mediate cross-species entry of bat influenza viruses. Nature. 2019 03; 567(7746):109-112. Karakus U, Thamamongood T, Ciminski K, Ran W, Günther SC, Pohl MO, Eletto D, Jeney C, Hoffmann D, Reiche S, Schinköthe J, Ulrich R, Wiener J, Hayes MGB, Chang MW, Hunziker A, Yángüez E, Aydillo T, Krammer F, Oderbolz J, Meier M, Oxenius A, Halenius A, Zimmer G, Benner C, Hale BG, García-Sastre A, Beer M, Schwemmle M, Stertz S. PMID: 30787439.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. Nat Commun. 2019 01 24; 10(1):414. Fonseca GJ, Tao J, Westin EM, Duttke SH, Spann NJ, Strid T, Shen Z, Stender JD, Sakai M, Link VM, Benner C, Glass CK. PMID: 30679424.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela. PLoS Negl Trop Dis. 2018 12; 12(12):e0007053. Carlin AF, Wen J, Vizcarra EA, McCauley M, Chaillon A, Akrami K, Kim C, Ngono AE, Lara-Marquez ML, Smith DM, Glass CK, Schooley RT, Benner C, Shresta S. PMID: 30596671.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9172-E9181. Carlin AF, Vizcarra EA, Branche E, Viramontes KM, Suarez-Amaran L, Ley K, Heinz S, Benner C, Shresta S, Glass CK. PMID: 30206152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714.
      View in: PubMed   Mentions:    Fields:    
    24. Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018 09 06; 174(6):1522-1536.e22. Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, Rialdi A, White KM, Albrecht RA, Pache L, Marazzi I, García-Sastre A, Shaw ML, Benner C. PMID: 30146161.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    25. Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer. Mol Cell. 2018 06 07; 70(5):842-853.e7. Zhu Q, Hoong N, Aslanian A, Hara T, Benner C, Heinz S, Miga KH, Ke E, Verma S, Soroczynski J, Yates JR, Hunter T, Verma IM. PMID: 29861157.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 03 01; 69(5):915. Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY. PMID: 29499140.
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    27. Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717. Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL. PMID: 29378911.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell. 2018 01 18; 69(2):306-320.e4. Neal S, Jaeger PA, Duttke SH, Benner C, K Glass C, Ideker T, Hampton RY. PMID: 29351849.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    29. Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501.
      View in: PubMed   Mentions:    Fields:    
    30. Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes Dev. 2017 11 15; 31(22):2222-2234. Franks TM, McCloskey A, Shokirev MN, Benner C, Rathore A, Hetzer MW. PMID: 29269482.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    32. Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. Elife. 2017 10 02; 6. Kelso TWR, Porter DK, Amaral ML, Shokhirev MN, Benner C, Hargreaves DC. PMID: 28967863.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. Nat Commun. 2017 09 29; 8(1):754. Rahnamoun H, Lu H, Duttke SH, Benner C, Glass CK, Lauberth SM. PMID: 28963538.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    34. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 2017 09 20; 549(7673):548-552. Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. PMID: 28959974.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    35. Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845. Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 28512238.
      View in: PubMed   Mentions:    Fields:    
    36. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T. PMID: 28287406.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Nucleoporin-mediated regulation of cell identity genes. Genes Dev. 2016 Oct 15; 30(20):2253-2258. Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW. PMID: 27807035.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    38. Nascent RNA sequencing reveals distinct features in plant transcription. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12316-12321. Hetzel J, Duttke SH, Benner C, Chory J. PMID: 27729530.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 08 11; 536(7615):205-9. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE. PMID: 27487209.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 07 18; 214(2):155-66. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. PMID: 27432897.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    41. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71. Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 27198230.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    42. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 May 27; 352(6289):aad7993. Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. PMID: 27127234.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    43. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15713-8. Ding N, Hah N, Yu RT, Sherman MH, Benner C, Leblanc M, He M, Liddle C, Downes M, Evans RM. PMID: 26644586.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    44. Perspectives on Unidirectional versus Divergent Transcription. Mol Cell. 2015 Nov 05; 60(3):348-9. Duttke SH, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. PMID: 26545075.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    45. Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. PMID: 26496605.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    46. New roles for DNA cytosine modification, eRNA, anchors, and superanchors in developing B cell progenitors. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12776-81. Benner C, Isoda T, Murre C. PMID: 26417104.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    47. Hypoxia Drives Breast Tumor Malignancy through a TET-TNFa-p38-MAPK Signaling Axis. Cancer Res. 2015 Sep 15; 75(18):3912-24. Wu MZ, Chen SF, Nieh S, Benner C, Ger LP, Jan CI, Ma L, Chen CH, Hishida T, Chang HT, Lin YS, Montserrat N, Gascon P, Sancho-Martinez I, Izpisua Belmonte JC. PMID: 26294212.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    48. The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing. Genes Dev. 2015 Jun 15; 29(12):1224-38. Jacinto FV, Benner C, Hetzer MW. PMID: 26080816.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    49. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. PMID: 25945737.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    50. SMADs and YAP compete to control elongation of ß-catenin:LEF-1-recruited RNAPII during hESC differentiation. Mol Cell. 2015 Jun 04; 58(5):780-93. Estarás C, Benner C, Jones KA. PMID: 25936800.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    51. The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. Oncoscience. 2015; 2(4):362-72. Puto LA, Benner C, Hunter T. PMID: 26097870.
      View in: PubMed   Mentions:
    52. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica. 2015 Jul; 100(7):945-54. Kashyap MK, Kumar D, Villa R, La Clair JJ, Benner C, Sasik R, Jones H, Ghia EM, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. PMID: 25862704.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    53. Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nat Immunol. 2015 May; 16(5):485-94. Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I. PMID: 25822250.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. Genes Dev. 2015 Mar 15; 29(6):603-16. Chang AT, Liu Y, Ayyanathan K, Benner C, Jiang Y, Prokop JW, Paz H, Wang D, Li HR, Fu XD, Rauscher FJ, Yang J. PMID: 25762439.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    55. Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 2015 Apr 07; 131(14):1278-1290. Kurian L, Aguirre A, Sancho-Martinez I, Benner C, Hishida T, Nguyen TB, Reddy P, Nivet E, Krause MN, Nelles DA, Esteban CR, Campistol JM, Yeo GW, Belmonte JCI. PMID: 25739401.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):144-54. Heinz S, Romanoski CE, Benner C, Glass CK. PMID: 25650801.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    57. Human promoters are intrinsically directional. Mol Cell. 2015 Feb 19; 57(4):674-684. Duttke SHC, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. PMID: 25639469.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    58. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E297-302. Hah N, Benner C, Chong LW, Yu RT, Downes M, Evans RM. PMID: 25564661.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    59. B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell. 2014 Dec 18; 159(7):1524-37. Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, Dubois W, Nelson S, Vian L, Oliveira TY, Jankovic M, Hakim O, Gazumyan A, Pavri R, Awasthi P, Song B, Liu G, Chen L, Zhu S, Feigenbaum L, Staudt L, Murre C, Ruan Y, Robbiani DF, Pan-Hammarström Q, Nussenzweig MC, Casellas R. PMID: 25483777.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    60. Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization. Nucleic Acids Res. 2014 Nov 10; 42(20):12570-84. Kaikkonen MU, Niskanen H, Romanoski CE, Kansanen E, Kivelä AM, Laitalainen J, Heinz S, Benner C, Glass CK, Ylä-Herttuala S. PMID: 25352550.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    61. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell. 2014 Aug 14; 158(4):734-748. Li X, Liang Y, LeBlanc M, Benner C, Zheng Y. PMID: 25126782.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    62. The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics. 2014 Jul 22; 15:620. Benner C, van der Meulen T, Cacéres E, Tigyi K, Donaldson CJ, Huising MO. PMID: 25051960.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    63. Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs. Nat Commun. 2014 Jul 07; 5:4330. Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, Del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR, Belmonte JCI. PMID: 24999918.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    64. Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones. Cell Stem Cell. 2014 Jul 03; 15(1):31-6. Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla RD, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH, Li Y, Izpisua Belmonte JC. PMID: 24996168.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    65. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK. PMID: 24584051.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    66. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. Protein Cell. 2014 Jan; 5(1):59-68. Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Izpisua Belmonte JC. PMID: 24474197.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    67. Decoding a signature-based model of transcription cofactor recruitment dictated by cardinal cis-regulatory elements in proximal promoter regions. PLoS Genet. 2013 Nov; 9(11):e1003906. Benner C, Konovalov S, Mackintosh C, Hutt KR, Stunnenberg R, Garcia-Bassets I. PMID: 24244184.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    68. Differential L1 regulation in pluripotent stem cells of humans and apes. Nature. 2013 Nov 28; 503(7477):525-529. Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. PMID: 24153179.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    69. Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 06; 288(49):35222-36. Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS. PMID: 24145027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    70. Effect of natural genetic variation on enhancer selection and function. Nature. 2013 Nov 28; 503(7477):487-92. Heinz S, Romanoski CE, Benner C, Allison KA, Kaikkonen MU, Orozco LD, Glass CK. PMID: 24121437.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    71. Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. Protein Cell. 2013 Aug 27. Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Belmonte JC. PMID: 23982742.
      View in: PubMed   Mentions:    Fields:    
    72. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell. 2013 Aug 08; 51(3):310-25. Kaikkonen MU, Spann NJ, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass CK. PMID: 23932714.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    73. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27; 498(7455):511-5. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. PMID: 23728303.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    74. Mechanisms of in vivo binding site selection of the hematopoietic master transcription factor PU.1. Nucleic Acids Res. 2013 Jul; 41(13):6391-402. Pham TH, Minderjahn J, Schmidl C, Hoffmeister H, Schmidhofer S, Chen W, Längst G, Benner C, Rehli M. PMID: 23658224.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    75. Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21028-33. Mansson R, Welinder E, Åhsberg J, Lin YC, Benner C, Glass CK, Lucas JS, Sigvardsson M, Murre C. PMID: 23213261.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    76. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol. 2012 Dec; 13(12):1196-204. Lin YC, Benner C, Mansson R, Heinz S, Miyazaki K, Miyazaki M, Chandra V, Bossen C, Glass CK, Murre C. PMID: 23064439.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    77. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. PMID: 22566629.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    78. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states. Blood. 2012 Jun 14; 119(24):e161-71. Pham TH, Benner C, Lichtinger M, Schwarzfischer L, Hu Y, Andreesen R, Chen W, Rehli M. PMID: 22550342.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    79. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401. Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. PMID: 22174696.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    80. Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity. 2011 Sep 23; 35(3):413-25. Mercer EM, Lin YC, Benner C, Jhunjhunwala S, Dutkowski J, Flores M, Sigvardsson M, Ideker T, Glass CK, Murre C. PMID: 21903424.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    81. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature. 2011 May 15; 474(7351):390-4. Wang D, Garcia-Bassets I, Benner C, Li W, Su X, Zhou Y, Qiu J, Liu W, Kaikkonen MU, Ohgi KA, Glass CK, Rosenfeld MG, Fu XD. PMID: 21572438.
      View in: PubMed   Mentions: 360     Fields:    Translation:HumansCells
    82. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass CK. PMID: 21135125.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    83. Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev. 2010 Dec 15; 24(24):2760-5. Barish GD, Yu RT, Karunasiri M, Ocampo CB, Dixon J, Benner C, Dent AL, Tangirala RK, Evans RM. PMID: 21106671.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    84. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PMID: 20622854.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    85. Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation. Mol Cell Biol. 2010 Aug; 30(16):3943-55. Stender JD, Kim K, Charn TH, Komm B, Chang KC, Kraus WL, Benner C, Glass CK, Katzenellenbogen BS. PMID: 20547749.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    86. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. PMID: 20543837.
      View in: PubMed   Mentions: 226     Fields:    Translation:AnimalsCells
    87. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28; 38(4):576-89. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. PMID: 20513432.
      View in: PubMed   Mentions: 2199     Fields:    Translation:AnimalsCells
    88. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. PMID: 20489162.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    89. General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res. 2010 Feb 15; 70(4):1398-407. Gebhard C, Benner C, Ehrich M, Schwarzfischer L, Schilling E, Klug M, Dietmaier W, Thiede C, Holler E, Andreesen R, Rehli M. PMID: 20145141.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    90. Transcriptional effects of colony-stimulating factor-1 in mouse macrophages. Immunobiology. 2010 Jun; 215(6):466-74. El Chartouni C, Benner C, Eigner M, Lichtinger M, Rehli M. PMID: 19758725.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    91. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass CK. PMID: 19299558.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    92. In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics. 2008 Feb 07; 9:70. Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou Y, Winzeler EA. PMID: 18257930.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    93. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. PMID: 17525798.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    94. Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4852-7. Kwon YS, Garcia-Bassets I, Hutt KR, Cheng CS, Jin M, Liu D, Benner C, Wang D, Ye Z, Bibikova M, Fan JB, Duan L, Glass CK, Rosenfeld MG, Fu XD. PMID: 17360330.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    95. Systems biology of macrophages. Adv Exp Med Biol. 2007; 598:62-79. Maurya MR, Benner C, Pradervand S, Glass C, Subramaniam S. PMID: 17892205.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    96. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. J Lipid Res. 2006 May; 47(5):1097-111. Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, Bowers-Gentry RC, Buczynski MW, Cooper JA, Deems RA, Dennis EA. PMID: 16479018.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    97. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 09; 122(5):707-21. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. PMID: 16143103.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    98. Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays. BMC Bioinformatics. 2004 Apr 20; 5:42. Barrera L, Benner C, Tao YC, Winzeler E, Zhou Y. PMID: 15099405.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
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