Lieselot Carrette

Title(s)	Assistant Adjunct Professor, Psychiatry
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
ORCID	0000-0002-5217-2774
vCard	Download vCard

Biography

education and training

University of California, San Diego, USA	Project Scientist	09/2023	Psychiatry
The Scripps Research Institute, La Jolla, USA	Postdoc	06/2019	Neuroscience
Massachusetts General Hospital, Boston, USA	Postdoc	09/2018	Molecular Biology
Ghent University, Belgium	PhD	04/2014	Chemistry

awards and honors

Research Foundation - Flanders	2018 -	2022	Postdoctoral research fellowship - extension
Research Foundation - Flanders	2015 -	2018	Postdoctoral research fellowship
Belgian American Educational Foundation	2014 -	2015	Sofina-Gustave Boel Mobility Award
Research Foundation - Flanders	2009 -	2014	PhD aspirant fellowship
Ghent University	2009		Dow Chemical Company Award

Overview

overview

Research group under the Preclinical Addiction Research Consortium in the Department of Psychiatry at UCSD, studying neurodevelopmental and substance use disorders, with the help of rodent neuroimaging

keywords

Substance Use Disorders, Alcohol Use Disorders, Rett Syndrome, Single-Cell Whole-Brain Imaging, Functional Connectomics

Research

research activities and funding

Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to Compulsive Alcohol Use
UCSD Senate RG114345Jun 1, 2024 - May 31, 2025
Role: PI

CNS Effects of Alcohol: Cellular Neurobiology
NIH P60AA006420Dec 1, 1983 - Dec 31, 2022
Role: Co-Lead Functional Connectomics Component (2023-2027)

ORNG Applications

Faculty Mentoring

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats. Metabolites. 2025 Feb 04; 15(2). Vu T, Godbole S, Carrette LLG, Maturin L, George O, Saba LM, Kechris K. PMID: 39997720; PMCID: PMC11857688.

View in: PubMed Mentions:
Y and mitochondrial chromosomes in the heterogeneous stock rat population. G3 (Bethesda). 2024 Nov 06; 14(11). Okamoto F, Chitre AS, Missfeldt Sanches T, Chen D, Munro D, Aron AT, Beeson A, Bimschleger HV, Eid M, Garcia Martinez AG, Han W, Holl K, Jackson T, Johnson BB, King CP, Kuhn BN, Lamparelli AC, Netzley AH, Nguyen KH, Peng BF, Tripi JA, Wang T, Ziegler KS, Adams DJ, Baud A, Carrette LLG, Chen H, de Guglielmo G, Dorrestein P, George O, Ishiwari K, Jablonski MM, Jhou TC, Kallupi M, Knight R, Meyer PJ, Solberg Woods LC, Polesskaya O, Palmer AA. PMID: 39250761; PMCID: PMC11540319.

View in: PubMed Mentions: 2 Fields:
Gen Genetics Mol Molecular Biology
Translation:Animals Cells
Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct. Elife. 2024 Nov 01; 12. de Guglielmo G, Carrette L, Kallupi M, Brennan M, Boomhower B, Maturin L, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Martinez AR, Velarde N, Othman D, Sichel B, Ramborger J, Lau J, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Bonnet-Zahedi S, Sneddon EA, Avelar A, Plasil SL, Mosquera J, Crook C, Chun L, Vang A, Milan KK, Schweitzer P, Lin B, Peng B, Chitre AS, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 39484794; PMCID: PMC11530236.

View in: PubMed Mentions: Fields:
Bio Biology
Translation:Animals
Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine. Neuropharmacology. 2024 Aug 01; 253:109959. Shankar K, Bonnet-Zahedi S, Milan K, D'argence AR, Sneddon E, Qiao R, Chonwattangul S, Carrette LLG, Kallupi M, George O. PMID: 38648925; PMCID: PMC11734747.

View in: PubMed Mentions: Fields:
Neu Neurology Pha Pharmacology
Translation:Animals Cells
Antagonists of the stress and opioid systems restore the functional connectivity of the prefrontal cortex during alcohol withdrawal through divergent mechanisms. bioRxiv. 2024 Jan 14. Carrette LLG, Santos A, Brennan M, Othman D, Collazo A, George O. PMID: 37873478; PMCID: PMC10592857.

View in: PubMed Mentions:
Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats. Horm Behav. 2024 03; 159:105447. Shankar K, Ramborger J, Bonnet-Zahedi S, Carrette LLG, George O. PMID: 37926623; PMCID: PMC11384237.

View in: PubMed Mentions: 2 Fields:
Beh Behavioral Sciences End Endocrinology
Translation:Animals
Author Correction: Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023 Nov; 26(11):2035. Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. PMID: 37845545; PMCID: PMC10620070.

View in: PubMed Mentions: Fields:
Neu Neurology
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023 Nov; 26(11):1868-1879. Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. PMID: 37798411; PMCID: PMC10620093.

View in: PubMed Mentions: 9 Fields:
Neu Neurology
Translation:Humans Animals Cells
Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self-administration. Addict Biol. 2023 09; 28(9):e13316. Beldjoud H, Avelar A, de Guglielmo G, Kallupi M, Sedighim S, Velarde N, Boomhower B, Rizo N, Carrette LLG, George O. PMID: 37644893; PMCID: PMC10614571.

View in: PubMed Mentions: 6 Fields:
Sub Substance-Related Disorders
Translation:Animals
Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice. eNeuro. 2023 06; 10(6). Carrette LLG, Kimbrough A, Davoudian PA, Kwan AC, Collazo A, George O. PMID: 37295945; PMCID: PMC10306126.

View in: PubMed Mentions: 5 Fields:
Bra Brain Neu Neurology
Translation:Animals
Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway. Biomedicines. 2023 May 05; 11(5). Kumaresan V, Lim Y, Juneja P, Tipton AE, de Guglielmo G, Carrette LLG, Kallupi M, Maturin L, Liu Y, George O, Zhang H. PMID: 37239038; PMCID: PMC10216163.

View in: PubMed Mentions: 2
Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice. bioRxiv. 2023 Mar 31. Carrette LLG, Kimbrough A, Davoudian PA, Kwan AC, Collazo A, George O. PMID: 37034602; PMCID: PMC10081261.

View in: PubMed Mentions:
Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Front Neurosci. 2022; 16:858427. Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. PMID: 35651629; PMCID: PMC9149415.

View in: PubMed Mentions: 13
Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. Front Behav Neurosci. 2022; 16:832899. Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. PMID: 35316955; PMCID: PMC8934439.

View in: PubMed Mentions: 5
Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3423-3433. Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. PMID: 34415376; PMCID: PMC8889911.

View in: PubMed Mentions: 7 Fields:
Psy Psychopharmacology
Translation:Animals
The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3). Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455; PMCID: PMC8213442.

View in: PubMed Mentions: 16 Fields:
Bra Brain Neu Neurology
Translation:Animals
Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats. Psychopharmacology (Berl). 2021 Aug; 238(8):2201-2211. Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. PMID: 33909102; PMCID: PMC8295227.

View in: PubMed Mentions: 6 Fields:
Psy Psychopharmacology
Translation:Animals
Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. Neuropsychopharmacology. 2020 10; 45(11):1909-1919. Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. PMID: 32544927; PMCID: PMC7608444.

View in: PubMed Mentions: 28 Fields:
Neu Neurology Psy Psychopharmacology
Translation:Animals
Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2140-2148. Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. PMID: 31932450; PMCID: PMC6994987.

View in: PubMed Mentions: 23 Fields:
Sci Science
Translation:Humans Animals
Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 10; 43(10):2079-2089. Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. PMID: 31403700; PMCID: PMC6779498.

View in: PubMed Mentions: 3 Fields:
Sub Substance-Related Disorders
Translation:Animals Cells
Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8185-8190. Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT. PMID: 30038001; PMCID: PMC6094149.

View in: PubMed Mentions: 21 Fields:
Sci Science
Translation:Humans Animals
A Thiolactone Strategy for Straightforward Synthesis of Disulfide-Linked Side-Chain-to-Tail Cyclic Peptides Featuring an N-Terminal Modification Handle. Chembiochem. 2018 03 16; 19(6):641-646. Van Lysebetten D, Felissati S, Antonatou E, Carrette LLG, Espeel P, Focquet E, Du Prez FE, Madder A. PMID: 29314620.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells
A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E668-E675. Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT. PMID: 29282321; PMCID: PMC5789928.

View in: PubMed Mentions: 50 Fields:
Sci Science
Translation:Animals Cells
A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14366-14371. Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. PMID: 28182563; PMCID: PMC5167172.

View in: PubMed Mentions: 19 Fields:
Sci Science
Translation:Animals Cells
Furan oxidation based cross-linking: a new approach for the study and targeting of nucleic acid and protein interactions. Chem Commun (Camb). 2016 Jan 28; 52(8):1539-54. Carrette LL, Gyssels E, De Laet N, Madder A. PMID: 26679922.

View in: PubMed Mentions: 10 Fields:
Che Chemistry
Triplex crosslinking through furan oxidation requires perturbation of the structured triple-helix. Chembiochem. 2015 Mar 02; 16(4):651-8. Gyssels E, Carrette LL, Vercruysse E, Stevens K, Madder A. PMID: 25630588.

View in: PubMed Mentions: Fields:
Bio Biochemistry
Translation:Cells
A mildly inducible and selective cross-link methodology for RNA duplexes. Org Biomol Chem. 2014 Feb 14; 12(6):931-5. Carrette LL, Gyssels E, Loncke J, Madder A. PMID: 24357353.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry Che Chemistry
Translation:Cells
A synthetic oligonucleotide model for evaluating the oxidation and crosslinking propensities of natural furan-modified DNA. Chembiochem. 2014 Jan 03; 15(1):103-7. Carrette LL, Madder A. PMID: 24323800.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells
Toxicity inspired cross-linking for probing DNA-peptide interactions. Bioconjug Chem. 2013 Dec 18; 24(12):2008-14. Carrette LL, Morii T, Madder A. PMID: 24180528.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells
Multifunctionalized sequence-defined oligomers from a single building block. Angew Chem Int Ed Engl. 2013 Dec 09; 52(50):13261-4. Espeel P, Carrette LL, Bury K, Capenberghs S, Martins JC, Du Prez FE, Madder A. PMID: 24174322.

View in: PubMed Mentions: 22 Fields:
Che Chemistry
DNA interstrand cross-link formation using furan as a masked reactive aldehyde. Curr Protoc Nucleic Acid Chem. 2013 Oct 08; 54:5.12.1-5.12.16. Carrette LLG, Gyssels E, Madder A. PMID: 24510798.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry Techniques
Translation:Cells