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    Kathleen Fisch

    TitleExecutive Director
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0681
    CA La Jolla 92093
    Phone858-534-9452
    Emailkfisch@ucsd.edu
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of California, BerkeleyB.A.Integrative Biology
      University of California, DavisPh.D.Ecology: Population Genetics

      Collapse Overview 
      Collapse Overview
      Dr. Kathleen Fisch is the Executive Director of the UC San Diego Center for Computational Biology & Bioinformatics (CCBB) in the Department of Medicine and serves as the Co-Director of the ACTRI Center for Accelerating Drug Development (CADD). Dr. Fisch spearheads the development of a vibrant, leading edge vision for computational biology, bioinformatics support and infrastructure at UCSD Health Sciences.


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      Collapse Featured Publications
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch K, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017 Sep 21; 171(1):103-119.e18. PMID: 28938112.
        View in: PubMed
      2. Rosenthal SB, Len J, Webster M, Gary A, Birmingham A, Fisch K. Interactive network visualization in Jupyter notebooks: visJS2jupyter. Bioinformatics. 2017 Sep 14. PMID: 28968701.
        View in: PubMed
      3. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017 Aug 28. PMID: 28846070.
        View in: PubMed
      4. Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch K, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 Apr; 7(4):410-423. PMID: 28188128.
        View in: PubMed
      5. Cowell AN, Loy DE, Sundararaman SA, Valdivia H, Fisch K, Lescano AG, Baldeviano GC, Durand S, Gerbasi V, Sutherland CJ, Nolder D, Vinetz JM, Hahn BH, Winzeler EA. Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples. MBio. 2017 Feb 07; 8(1). PMID: 28174312.
        View in: PubMed
      6. Akagi R, Akatsu Y, Fisch K, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-ß signaling in chondrocytes. Osteoarthritis Cartilage. 2017 Jun; 25(6):943-951. PMID: 27884645.
        View in: PubMed
      7. Chen S, Miyazaki M, Chandra V, Fisch K, Chang AN, Murre C. Id3 Orchestrates Germinal Center B Cell Development. Mol Cell Biol. 2016 Oct 15; 36(20):2543-52. PMID: 27457619.
        View in: PubMed
      8. Alvarez-Garcia O, Fisch K, Wineinger NE, Akagi R, Saito M, Sasho T, Su AI, Lotz MK. Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage. Arthritis Rheumatol. 2016 Aug; 68(8):1876-86. PMID: 26881698; PMCID: PMC4963260 [Available on 08/01/17].
      9. Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch K, Shen T, Su AI, Lotz MK. Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy. Osteoarthritis Cartilage. 2016 Sep; 24(9):1639-47. PMID: 27118398; PMCID: PMC4992644 [Available on 09/01/17].
      10. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang JT. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. 2016 Apr 19; 7(16):21527-41. PMID: 26930717; PMCID: PMC5008303.
      11. Meißner T, Fisch K, Gioia L, Su AI. OncoRep: an n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing. BMC Med Genomics. 2015 May 21; 8:24. PMID: 25989980; PMCID: PMC4494802.
      12. Fisch K, Meißner T, Gioia L, Ducom JC, Carland TM, Loguercio S, Su AI. Omics Pipe: a community-based framework for reproducible multi-omics data analysis. Bioinformatics. 2015 Jun 01; 31(11):1724-8. PMID: 25637560; PMCID: PMC4443682.
      13. Fisch, K., Kozfkay, C., Ivy, J., Ryder, O., R. Waples. Fish hatchery genetic management techniques: Integrating Theory with Implementation. North American Journal of Aquaculture: HaMAR Special Section. 2015; 3(77):343-357.
      14. LaCava, M., Fisch, K., Nagel, M., Lindberg, J., May, B., Finger, A. Spawning behavior of cultured delta smelt (Hypomesus transpacificus) in a conservation hatchery. North American Journal of Aquaculture. 2015; 3(77):255-266.
      15. Wei N, Shi Y, Truong LN, Fisch K, Xu T, Gardiner E, Fu G, Hsu YS, Kishi S, Su AI, Wu X, Yang XL. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Mol Cell. 2014 Oct 23; 56(2):323-32. PMID: 25284223; PMCID: PMC4224670.
      16. Fisch, K., Mahardja, B., Burton, R., May, B. Hybridization between delta smelt and two other species within the family Osmeridae in the San Francisco Bay-Delta. Conservation Genetics. 2014; (15):489-494.
      17. Lindberg, J., Tigan, G., Ellison, L., Rettinghouse, T., Nagel, M., Fisch, K. Aquaculture methods for a genetically managed population of endangered delta smelt. North American Journal of Aquaculture. 2013; 2(75):186-196.
      18. Fisch K, Ivy JA, Burton RS, May B. Evaluating the performance of captive breeding techniques for conservation hatcheries: a case study of the delta smelt captive breeding program. J Hered. 2013 Jan-Feb; 104(1):92-104. PMID: 23125405.
        View in: PubMed
      19. Fisch, K., Henderson, J., Burton, R., May, B. Population genetics and conservation implications for the endangered delta smelt in the San Francisco Bay-Delta. Conservation Genetics. 2011; 6(12):1421-1434.
      20. Israel, J., Fisch, K., Turner, T., Waples, R. Conservation of native Bay-Delta fishes: past experience and future considerations for artificial propagation of Chinook salmon, delta smelt, and green sturgeon. San Francisco Estuary & Watershed Science. 2011; 1(9):1-20.
      21. Fisch K, Petersen JL, Baerwald MR, Pedroia JK, May B. Characterization of 24 microsatellite loci in delta smelt, Hypomesus transpacificus, and their cross-species amplification in two other smelt species of the Osmeridae family. Mol Ecol Resour. 2009 Jan; 9(1):405-8. PMID: 21564663.
        View in: PubMed