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Tariq Rana

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0762
La Jolla CA 92093
Phone858-246-1100
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    Collapse Research 
    Collapse Research Activities and Funding
    Identification and Regulation of RNA Modification by HIV infection and Methamphetamine
    NIH/NIDA R01DA046171Apr 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Regulation of HIV-1 Replication by Cellular IncRNAs
    NIH/NIAID R21AI125103Aug 5, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Modeling HIV/AIDS Associated Neurological Disorders with Human Pluripotent Cells
    NIH/NIDA DP1DA039562Mar 1, 2015 - Jan 31, 2020
    Role: Principal Investigator
    Innate Immune Responses and Vaccines Against Tumor-Associated Herpesviruses
    NIH/NCI P01CA177322Sep 19, 2014 - Aug 31, 2019
    Role: Co-Investigator
    Preclinical Development of HIV-1 Vif Antagonists
    NIH P01MH100942Aug 19, 2013 - Jul 31, 2018
    Role: Co-Investigator
    Regulation of HIV infection by Methamphetamine and non-coding RNAs
    NIH/NIDA R01DA030199Jul 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    RNAi-Based Therapy of ALS
    NIH/NINDS R01NS060856Aug 5, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Preclinical Development of HIV-1 Vif Antagonists
    NIH U19MH081836Apr 16, 2007 - Mar 31, 2013
    Role: Co-Investigator
    TARGETING HIV VIF PROTEIN
    NIH/NIAID R21AI054181Sep 30, 2002 - Aug 31, 2004
    Role: Principal Investigator
    Targeting Ensembles of Drug Resistant HIV-Protease
    NIH P01GM066524Aug 20, 2002 - Aug 31, 2013
    Role: Co-Investigator
    INHIBITION OF HIV REPLICATION
    NIH/NIAID R01AI045466Jul 1, 2000 - Jun 30, 2004
    Role: Principal Investigator
    INHIBITION OF HIV REPLICATION
    NIH/NIAID R21AI045466Sep 30, 1999 - Sep 30, 2000
    Role: Principal Investigator
    Mechanisms of innate immunity against HIV
    NIH/NIAID R01AI043198Jun 1, 1998 - Jan 31, 2015
    Role: Principal Investigator
    Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    NIH/NIAID R01AI041404Sep 1, 1997 - Jun 30, 2016
    Role: Principal Investigator
    Structure and Function of Ribonucleoprotein Complexes Modulating HIV Replication
    NIH/NIAID R56AI041404Sep 1, 1997 - Aug 31, 2010
    Role: Principal Investigator
    STRUCTURE OF CHEMICALLY MODIFIED TAT-TAR COMPLEX
    NIH/FIC R03TW000702Jul 1, 1996 - Jun 30, 1999
    Role: Principal Investigator
    PROBING TAT TAR INTERACTIONS IN HIV BY CHEMICAL METHODS
    NIH/NIAID K02AI001369Apr 1, 1996 - Mar 31, 2001
    Role: Principal Investigator
    TAT-TAR INTERACTIONS IN HIV PROBED BY CHEMICAL METHODS
    NIH/NIAID R29AI034785Jul 15, 1993 - Jun 30, 1998
    Role: Principal Investigator
    Cancer Center Support Grant (CCSG)
    NIH/NCI P30CA030199Jul 1, 1981 - Apr 30, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana T, Traver D, Miller YI. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun. 2018 Apr 03; 9(1):1310. PMID: 29615667.
      View in: PubMed
    2. Yau EH, Rana T. Next-Generation Sequencing of Genome-Wide CRISPR Screens. Methods Mol Biol. 2018; 1712:203-216. PMID: 29224076.
      View in: PubMed
    3. Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana T. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res. 2017 11 15; 77(22):6330-6339. PMID: 28954733.
      View in: PubMed
    4. Tiwari SK, Dang J, Qin Y, Lichinchi G, Bansal V, Rana T. Zika virus infection reprograms global transcription of host cells to allow sustained infection. Emerg Microbes Infect. 2017 Apr 26; 6(4):e24. PMID: 28442752.
      View in: PubMed
    5. Xiong XP, Kurthkoti K, Chang KY, Li JL, Ren X, Ni JQ, Rana T, Zhou R. miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila. PLoS Pathog. 2016 Nov; 12(11):e1006034. PMID: 27893816.
      View in: PubMed
    6. Gong D, Kim YH, Xiao Y, Du Y, Xie Y, Lee KK, Feng J, Farhat N, Zhao D, Shu S, Dai X, Chanda SK, Rana T, Krogan NJ, Sun R, Wu TT. A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export. Cell Host Microbe. 2016 Nov 09; 20(5):642-653. PMID: 27832591.
      View in: PubMed
    7. Han T, Yang CS, Chang KY, Zhang D, Imam FB, Rana T. Identification of novel genes and networks governing hematopoietic stem cell development. EMBO Rep. 2016 12; 17(12):1814-1828. PMID: 27797851.
      View in: PubMed
    8. Lichinchi G, Zhao BS, Wu Y, Lu Z, Qin Y, He C, Rana T. Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016 Nov 09; 20(5):666-673. PMID: 27773536.
      View in: PubMed
    9. Zhou Y, Dang J, Chang KY, Yau E, Aza-Blanc P, Moscat J, Rana T. miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3. Cancer Res. 2016 10 01; 76(19):5777-5787. PMID: 27698189.
      View in: PubMed
    10. Mohammed I, Kummetha IR, Singh G, Sharova N, Lichinchi G, Dang J, Stevenson M, Rana T. 1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists. J Med Chem. 2016 Aug 25; 59(16):7677-82. PMID: 27509004.
      View in: PubMed
    11. Yang CS, Chang KY, Dang J, Rana T. Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity. Sci Rep. 2016 06 01; 6:26899. PMID: 27247273.
      View in: PubMed
    12. Dang J, Tiwari SK, Lichinchi G, Qin Y, Patil VS, Eroshkin AM, Rana T. Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3. Cell Stem Cell. 2016 08 04; 19(2):258-265. PMID: 27162029.
      View in: PubMed
    13. Johnson TC, Chin MR, Han T, Shen JP, Rana T, Siegel D. Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion. J Am Chem Soc. 2016 05 11; 138(18):6068-73. PMID: 27096704.
      View in: PubMed
    14. Lichinchi G, Gao S, Saletore Y, Gonzalez GM, Bansal V, Wang Y, Mason CE, Rana T. Dynamics of the human and viral m(6)A RNA methylomes during HIV-1 infection of T cells. Nat Microbiol. 2016 Feb 22; 1:16011. PMID: 27572442.
      View in: PubMed
    15. Dang J, Rana T. Enhancing Induced Pluripotent Stem Cell Generation by MicroRNA. Methods Mol Biol. 2016; 1357:71-84. PMID: 25687299.
      View in: PubMed
    16. Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana T, Geyer M, Tong L, Shokat KM, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016 Jan 01; 30(1):117-31. PMID: 26728557; PMCID: PMC4701974.
    17. McCarroll JA, Dwarte T, Baigude H, Dang J, Yang L, Erlich RB, Kimpton K, Teo J, Sagnella SM, Akerfeldt MC, Liu J, Phillips PA, Rana T, Kavallaris M. Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer. Oncotarget. 2015 May 20; 6(14):12020-34. PMID: 25557168; PMCID: PMC4494920.
    18. Lin N, Dang J, Rana T. Haunting the HOXA Locus: Two Faces of lncRNA Regulation. Cell Stem Cell. 2015 May 07; 16(5):449-50. PMID: 25957895.
      View in: PubMed
    19. Baigude H, Rana T. Strategies to antagonize miRNA functions in vitro and in vivo. Nanomedicine (Lond). 2014 Nov; 9(16):2545-55. PMID: 25490425.
      View in: PubMed
    20. Li Z, Rana T. Decoding the noncoding: prospective of lncRNA-mediated innate immune regulation. RNA Biol. 2014; 11(8):979-85. PMID: 25482890; PMCID: PMC4615744.
    21. Li Z, Dang J, Chang KY, Rana T. MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA. 2014 Dec; 20(12):1900-15. PMID: 25336587; PMCID: PMC4238355.
    22. Han J, Cai J, Borjihan W, Ganbold T, Rana T, Baigude H. Preparation of novel curdlan nanoparticles for intracellular siRNA delivery. Carbohydr Polym. 2015 Mar 06; 117:324-30. PMID: 25498642; PMCID: PMC4268549.
    23. Yang CS, Chang KY, Rana T. Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming. Cell Rep. 2014 Jul 24; 8(2):327-37. PMID: 25043178; PMCID: PMC4152236.
    24. Li Z, Rana T. Therapeutic targeting of microRNAs: current status and future challenges. Nat Rev Drug Discov. 2014 Aug; 13(8):622-38. PMID: 25011539.
      View in: PubMed
    25. Sakurai K, Talukdar I, Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, Dermardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana T. Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming. Cell Stem Cell. 2014 Apr 03; 14(4):523-34. PMID: 24702998; PMCID: PMC4071169.
    26. Lin N, Chang KY, Li Z, Gates K, Rana ZA, Dang J, Zhang D, Han T, Yang CS, Cunningham TJ, Head SR, Duester G, Dong PD, Rana T. An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Mol Cell. 2014 Mar 20; 53(6):1005-19. PMID: 24530304; PMCID: PMC4010157.
    27. Henzler CM, Li Z, Dang J, Arcila ML, Zhou H, Liu J, Chang KY, Bassett DS, Rana T, Kosik KS. Staged miRNA re-regulation patterns during reprogramming. Genome Biol. 2013 Dec 31; 14(12):R149. PMID: 24380417; PMCID: PMC4053856.
    28. Li Z, Chao TC, Chang KY, Lin N, Patil VS, Shimizu C, Head SR, Burns JC, Rana T. The long noncoding RNA THRIL regulates TNFa expression through its interaction with hnRNPL. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1002-7. PMID: 24371310; PMCID: PMC3903238.
    29. Patil VS, Zhou R, Rana T. Gene regulation by non-coding RNAs. Crit Rev Biochem Mol Biol. 2014 Jan-Feb; 49(1):16-32. PMID: 24164576; PMCID: PMC4721600.
    30. Shen Y, Altman MD, Ali A, Nalam MN, Cao H, Rana T, Schiffer CA, Tidor B. Testing the substrate-envelope hypothesis with designed pairs of compounds. ACS Chem Biol. 2013 Nov 15; 8(11):2433-41. PMID: 23952265; PMCID: PMC3833293.
    31. Xiong XP, Kurthkoti K, Chang KY, Lichinchi G, De N, Schneemann A, MacRae IJ, Rana T, Perrimon N, Zhou R. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16520-5. PMID: 24067655; PMCID: PMC3799365.
    32. Nalam MN, Ali A, Reddy GS, Cao H, Anjum SG, Altman MD, Yilmaz NK, Tidor B, Rana T, Schiffer CA. Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance. Chem Biol. 2013 Sep 19; 20(9):1116-24. PMID: 24012370; PMCID: PMC3934494.
    33. Silver NW, King BM, Nalam MN, Cao H, Ali A, Kiran Kumar Reddy GS, Rana T, Schiffer CA, Tidor B. Efficient Computation of Small-Molecule Configurational Binding Entropy and Free Energy Changes by Ensemble Enumeration. J Chem Theory Comput. 2013 Nov 12; 9(11):5098-5115. PMID: 24250277.
      View in: PubMed
    34. Baigude H, Su J, McCarroll J, Rana T. In Vivo Delivery of RNAi by Reducible Interfering Nanoparticles (iNOPs). ACS Med Chem Lett. 2013 Aug 08; 4(8):720-723. PMID: 24319542.
      View in: PubMed
    35. Zhou R, Rana T. RNA-based mechanisms regulating host-virus interactions. Immunol Rev. 2013 May; 253(1):97-111. PMID: 23550641; PMCID: PMC3695692.
    36. Yang CS, Rana T. Learning the molecular mechanisms of the reprogramming factors: let's start from microRNAs. Mol Biosyst. 2013 Jan 27; 9(1):10-7. PMID: 23037570; PMCID: PMC3933261.
    37. Parai MK, Huggins DJ, Cao H, Nalam MN, Ali A, Schiffer CA, Tidor B, Rana T. Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J Med Chem. 2012 Jul 26; 55(14):6328-41. PMID: 22708897; PMCID: PMC3409094.
    38. Mohammed I, Parai MK, Jiang X, Sharova N, Singh G, Stevenson M, Rana T. SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor. ACS Med Chem Lett. 2012 Jun 14; 3(6):465-469. PMID: 24533175.
      View in: PubMed
    39. Baigude H. miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Angew Chem Int Ed Engl. 2012 Jun 11; 51(24):5880-3. PMID: 22566243; PMCID: PMC3501383.
    40. Ali A, Wang J, Nathans RS, Cao H, Sharova N, Stevenson M, Rana T. Synthesis and structure-activity relationship studies of HIV-1 virion infectivity factor (Vif) inhibitors that block viral replication. ChemMedChem. 2012 Jul; 7(7):1217-29. PMID: 22555953; PMCID: PMC3517065.
    41. Zhou H, Arcila ML, Li Z, Lee EJ, Henzler C, Liu J, Rana T, Kosik KS. Deep annotation of mouse iso-miR and iso-moR variation. Nucleic Acids Res. 2012 Jul; 40(13):5864-75. PMID: 22434881; PMCID: PMC3401436.
    42. Li Z, Rana T. Molecular mechanisms of RNA-triggered gene silencing machineries. Acc Chem Res. 2012 Jul 17; 45(7):1122-31. PMID: 22304792; PMCID: PMC3398549.
    43. Li Z, Rana T. A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun. 2012; 3:1085. PMID: 23011139; PMCID: PMC3658009.
    44. O'Brien SK, Knight KL, Rana T. Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation. J Cell Physiol. 2012 Jan; 227(1):383-9. PMID: 21503884; PMCID: PMC3562545.
    45. Li Z, Rana T. Using microRNAs to enhance the generation of induced pluripotent stem cells. Curr Protoc Stem Cell Biol. 2012; Chapter 4:Unit 4A.4. PMID: 22415842.
      View in: PubMed
    46. Baigude H, Rana T. Interfering nanoparticles for silencing microRNAs. Methods Enzymol. 2012; 509:339-53. PMID: 22568914; PMCID: PMC3933207.
    47. Yang CS, Lopez CG, Rana T. Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells. 2011 Oct; 29(10):1528-36. PMID: 21898684; PMCID: PMC3419601.
    48. Yang CS, Li Z, Rana T. microRNAs modulate iPS cell generation. RNA. 2011 Aug; 17(8):1451-60. PMID: 21693621; PMCID: PMC3153970.
    49. Li Z, Yang CS, Nakashima K, Rana T. Small RNA-mediated regulation of iPS cell generation. EMBO J. 2011 Mar 02; 30(5):823-34. PMID: 21285944; PMCID: PMC3049216.
    50. Su J, Baigude H, McCarroll J, Rana T. Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Res. 2011 Mar; 39(6):e38. PMID: 21212128; PMCID: PMC3064800.
    51. Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Schiffer CA, Rana T. Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones. J Med Chem. 2010 Nov 11; 53(21):7699-708. PMID: 20958050; PMCID: PMC2996262.
    52. Lu CC, Li Z, Chu CY, Feng J, Feng J, Sun R, Rana T. MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle. EMBO Rep. 2010 Oct; 11(10):784-90. PMID: 20847741; PMCID: PMC2948186.
    53. Ghosh A, Mukherjee K, Jiang X, Zhou Y, McCarroll J, Qu J, Swain PM, Baigude H, Rana T. Design and assembly of new nonviral RNAi delivery agents by microwave-assisted quaternization (MAQ) of tertiary amines. Bioconjug Chem. 2010 Sep 15; 21(9):1581-7. PMID: 20722369; PMCID: PMC3012264.
    54. James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana T, Morley SJ, Longmore GD, Bushell M, Sharp TV. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12499-504. PMID: 20616046; PMCID: PMC2906597.
    55. O'Brien SK, Cao H, Nathans R, Ali A, Rana T. P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes. J Biol Chem. 2010 Sep 24; 285(39):29713-20. PMID: 20551309; PMCID: PMC2943301.
    56. Nalam MN, Ali A, Altman MD, Reddy GS, Chellappan S, Kairys V, Ozen A, Cao H, Gilson MK, Tidor B, Rana T, Schiffer CA. Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance. J Virol. 2010 May; 84(10):5368-78. PMID: 20237088; PMCID: PMC2863851.
    57. McCarroll J, Baigude H, Yang CS, Rana T. Nanotubes functionalized with lipids and natural amino acid dendrimers: a new strategy to create nanomaterials for delivering systemic RNAi. Bioconjug Chem. 2010 Jan; 21(1):56-63. PMID: 19957956; PMCID: PMC2814541.
    58. Baigude H, Rana T. Delivery of therapeutic RNAi by nanovehicles. Chembiochem. 2009 Oct 12; 10(15):2449-54. PMID: 19688785; PMCID: PMC3517099.
    59. Ali A, Ghosh A, Nathans RS, Sharova N, O'Brien S, Cao H, Stevenson M, Rana T. Identification of flavopiridol analogues that selectively inhibit positive transcription elongation factor (P-TEFb) and block HIV-1 replication. Chembiochem. 2009 Aug 17; 10(12):2072-80. PMID: 19603446; PMCID: PMC2754223.
    60. Nathans R, Chu CY, Serquina AK, Lu CC, Cao H, Rana T. Cellular microRNA and P bodies modulate host-HIV-1 interactions. Mol Cell. 2009 Jun 26; 34(6):696-709. PMID: 19560422; PMCID: PMC2763548.
    61. Bélanger F, Baigude H, Rana T. U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex. J Mol Biol. 2009 Mar 06; 386(4):1094-107. PMID: 19244621; PMCID: PMC2754221.
    62. Jorissen RN, Reddy GS, Ali A, Altman MD, Chellappan S, Anjum SG, Tidor B, Schiffer CA, Rana T, Gilson MK. Additivity in the analysis and design of HIV protease inhibitors. J Med Chem. 2009 Feb 12; 52(3):737-54. PMID: 19193159; PMCID: PMC2715819.
    63. Nathans R, Cao H, Sharova N, Ali A, Sharkey M, Stranska R, Stevenson M, Rana T. Small-molecule inhibition of HIV-1 Vif. Nat Biotechnol. 2008 Oct; 26(10):1187-92. PMID: 18806783; PMCID: PMC2693000.
    64. Cao H, Yang CS, Rana T. Evolutionary emergence of microRNAs in human embryonic stem cells. PLoS One. 2008 Jul 30; 3(7):e2820. PMID: 18665260; PMCID: PMC2474702.
    65. Chu CY, Rana T. Potent RNAi by short RNA triggers. RNA. 2008 Sep; 14(9):1714-9. PMID: 18658119; PMCID: PMC2525957.
    66. Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana T, Tidor B. HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J Am Chem Soc. 2008 May 14; 130(19):6099-113. PMID: 18412349; PMCID: PMC3465729.
    67. Wang H, Ghosh A, Baigude H, Yang CS, Qiu L, Xia X, Zhou H, Rana T, Xu Z. Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem. 2008 Jun 06; 283(23):15845-52. PMID: 18367449; PMCID: PMC2414310.
    68. Chu CY, Rana T. Small RNAs: regulators and guardians of the genome. J Cell Physiol. 2007 Nov; 213(2):412-9. PMID: 17674365.
      View in: PubMed
    69. Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana T. Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem. 2007 Sep 06; 50(18):4316-28. PMID: 17696512; PMCID: PMC3862176.
    70. Robb GB, Rana T. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol Cell. 2007 May 25; 26(4):523-37. PMID: 17531811.
      View in: PubMed
    71. Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana T, Schiffer CA, Gilson MK. Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis. Chem Biol Drug Des. 2007 May; 69(5):298-313. PMID: 17539822.
      View in: PubMed
    72. Baigude H, McCarroll J, Yang CS, Swain PM, Rana T. Design and creation of new nanomaterials for therapeutic RNAi. ACS Chem Biol. 2007 Apr 24; 2(4):237-41. PMID: 17432823.
      View in: PubMed
    73. Chiu YL, Cao H, Rana T. Quantitative analysis of RNA-mediated protein-protein interactions in living cells by FRET. Chem Biol Drug Des. 2007 Apr; 69(4):233-9. PMID: 17461970.
      View in: PubMed
    74. Rana T. Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol. 2007 Jan; 8(1):23-36. PMID: 17183358.
      View in: PubMed
    75. Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana T. Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. J Med Chem. 2006 Dec 14; 49(25):7342-56. PMID: 17149864.
      View in: PubMed
    76. Richter SN, Bélanger F, Zheng P, Rana T. Dynamics of nascent mRNA folding and RNA-protein interactions: an alternative TAR RNA structure is involved in the control of HIV-1 mRNA transcription. Nucleic Acids Res. 2006; 34(15):4278-92. PMID: 16920743; PMCID: PMC1616951.
    77. Chu CY, Rana T. Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol. 2006 Jul; 4(7):e210. PMID: 16756390; PMCID: PMC1475773.
    78. Wichroski MJ, Robb GB, Rana T. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2006 May; 2(5):e41. PMID: 16699599; PMCID: PMC1458959.
    79. Cao H, Tamilarasu N, Rana T. Orientation and affinity of HIV-1 Tat fragments in Tat-TAR complex determined by fluorescence resonance energy transfer. Bioconjug Chem. 2006 Mar-Apr; 17(2):352-8. PMID: 16536465.
      View in: PubMed
    80. Lee CW, Cao H, Ichiyama K, Rana T. Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine. Bioorg Med Chem Lett. 2005 Oct 01; 15(19):4243-6. PMID: 16054360.
      View in: PubMed
    81. Chiu YL, Dinesh CU, Chu CY, Ali A, Brown KM, Cao H, Rana T. Dissecting RNA-interference pathway with small molecules. Chem Biol. 2005 Jun; 12(6):643-8. PMID: 15975509.
      View in: PubMed
    82. Brown KM, Chu CY, Rana T. Target accessibility dictates the potency of human RISC. Nat Struct Mol Biol. 2005 May; 12(5):469-70. PMID: 15852021.
      View in: PubMed
    83. Lee HK, Cao H, Rana T. Design, microwave-assisted synthesis, and photophysical properties of small molecule organic antennas for luminescence resonance energy transfer. J Comb Chem. 2005 Mar-Apr; 7(2):279-84. PMID: 15762757.
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    84. Ping YH, Rana T. Mechanism of site-specific psoralen photoadducts formation in triplex DNA directed by psoralen-conjugated oligonucleotides. Biochemistry. 2005 Feb 22; 44(7):2501-9. PMID: 15709762.
      View in: PubMed
    85. Robb GB, Brown KM, Khurana J, Rana T. Specific and potent RNAi in the nucleus of human cells. Nat Struct Mol Biol. 2005 Feb; 12(2):133-7. PMID: 15643423.
      View in: PubMed
    86. Ping YH, Chu CY, Cao H, Jacque JM, Stevenson M, Rana T. Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology. 2004 Dec 27; 1:46. PMID: 15620346; PMCID: PMC545048.
    87. Wichroski MJ, Ichiyama K, Rana T. Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localization. J Biol Chem. 2005 Mar 04; 280(9):8387-96. PMID: 15537645.
      View in: PubMed
    88. Chiu YL, Ali A, Chu CY, Cao H, Rana T. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem Biol. 2004 Aug; 11(8):1165-75. PMID: 15324818.
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    89. Lee HK, Rana T. Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library. J Comb Chem. 2004 Jul-Aug; 6(4):504-8. PMID: 15244411.
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    90. Zhang L, Rana T. Solid-phase synthesis of alpha-(2-(benzylthio)-1,4-dihydro-6-methyl-4-p-tolylpyrimidine-5-carboxamido) acids: a new strategy to create diversity in heterocyclic scaffolds. J Comb Chem. 2004 Jul-Aug; 6(4):457-9. PMID: 15244403.
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    91. Chiu YL, Cao H, Jacque JM, Stevenson M, Rana T. Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol. 2004 Mar; 78(5):2517-29. PMID: 14963154; PMCID: PMC369228.
    92. Gelman MA, Richter S, Cao H, Umezawa N, Gellman SH, Rana T. Selective binding of TAR RNA by a Tat-derived beta-peptide. Org Lett. 2003 Oct 02; 5(20):3563-5. PMID: 14507173.
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    93. Chiu YL, Rana T. siRNA function in RNAi: a chemical modification analysis. RNA. 2003 Sep; 9(9):1034-48. PMID: 12923253; PMCID: PMC1370469.
    94. Hwang S, Tamilarasu N, Kibler K, Cao H, Ali A, Ping YH, Jeang KT, Rana T. Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication. J Biol Chem. 2003 Oct 03; 278(40):39092-103. PMID: 12857725.
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    95. Hamma T, Saleh A, Huq I, Rana T, Miller PS. Inhibition of HIV tat-TAR interactions by an antisense oligo-2'-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett. 2003 Jun 02; 13(11):1845-8. PMID: 12749881.
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    96. Kesavan V, Tamilarasu N, Cao H, Rana T. A new class of RNA-binding oligomers: peptoid amide and ester analogues. Bioconjug Chem. 2002 Nov-Dec; 13(6):1171-5. PMID: 12440849.
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    97. Chiu YL, Rana T. RNAi in human cells: basic structural and functional features of small interfering RNA. Mol Cell. 2002 Sep; 10(3):549-61. PMID: 12408823.
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    98. Chiu YL, Ho CK, Saha N, Schwer B, Shuman S, Rana T. Tat stimulates cotranscriptional capping of HIV mRNA. Mol Cell. 2002 Sep; 10(3):585-97. PMID: 12408826.
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    99. Zhou C, Rana T. A bimolecular mechanism of HIV-1 Tat protein interaction with RNA polymerase II transcription elongation complexes. J Mol Biol. 2002 Jul 26; 320(5):925-42. PMID: 12126615.
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    100. Richter S, Ping YH, Rana T. TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):7928-33. PMID: 12048247; PMCID: PMC122997.
    101. Richter S, Cao H, Rana T. Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation. Biochemistry. 2002 May 21; 41(20):6391-7. PMID: 12009901.
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    102. Dinman JD, Richter S, Plant EP, Taylor RC, Hammell AB, Rana T. The frameshift signal of HIV-1 involves a potential intramolecular triplex RNA structure. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5331-6. PMID: 11959986; PMCID: PMC122769.