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Brookie Best

Title(s)Professor, Pharmacy and Pediatrics, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0657
La Jolla CA 92093
Phone858-822-5550
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    Dr. Brookie Best is a Professor of Clinical Pharmacy and Pediatrics and the Associate Dean for Pharmacy Education at the University of California (UC), San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS) and the Department of Pediatrics, School of Medicine (SOM). She completed a Bachelor of Science degree at UC San Diego in Chemistry with an Emphasis in Chemical Education in 1994. She received her Pharm.D. degree in 1999 from UC San Francisco, and did her residency in Pharmacy Practice at the UC San Diego Medical Center in 2000. Dr. Best was an NICHD/NIH Fellowship recipient in Pediatric Clinical Pharmacology Research from 2001 to 2004, and completed a Masters of Advanced Studies (M.A.S.) in Clinical Research at UC San Diego in 2007. Dr. Best specializes in pharmacokinetics - the processes by which a drug is absorbed, distributed, metabolized and eliminated by the body - and maternal/fetal and pediatric clinical pharmacology research. Her research efforts have focused on studying anti-HIV drugs in pregnant women, children and non-pregnant adults. She also studies drugs used to treat Kawasaki disease, the leading cause of acquired heart disease in children.

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    Collapse Research Activities and Funding
    Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy
    NIH/NICHD U54HD071600Sep 26, 2011 - Jun 30, 2016
    Role: Co-Investigator
    Predoctoral Research Training in Maternal and Pediatric Pharmacology
    NIH/NICHD T35HD064385Apr 1, 2010 - Mar 31, 2016
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH PHARMACOLOGY FELLOWSHIP
    NIH/NICHD F32HD008722Apr 1, 2001
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Optimizing pharmacology studies in pregnant and lactating women using lessons from HIV: a consensus statement. Clin Pharmacol Ther. 2020 Sep 15. Eke AC, Olagunju A, Momper J, Penazzato M, Abrams E, Best BM, Capparelli EV, Bekker A, Belew Y, Kiser JJ, Struble K, Taylor G, Waitt C, Mirochnick M, Cressey TR, Colbers A. PMID: 32930408.
      View in: PubMed   Mentions:    Fields:    
    2. Pharmacokinetic Enhancement of HIV Antiretroviral Therapy During Pregnancy. J Clin Pharmacol. 2020 Aug 14. Salama E, Eke AC, Best BM, Mirochnick M, Momper JD. PMID: 32798276.
      View in: PubMed   Mentions:    Fields:    
    3. Innovative Approaches for Pharmacology Studies in Pregnant and Lactating Women: A Viewpoint and Lessons from HIV. Clin Pharmacokinet. 2020 Aug 05. Eke AC, Olagunju A, Best BM, Mirochnick M, Momper JD, Abrams E, Penazzato M, Cressey TR, Colbers A. PMID: 32757103.
      View in: PubMed   Mentions:    Fields:    
    4. Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling. Clin Pharmacokinet. 2020 May 25. Liu XI, Momper JD, Rakhmanina NY, Green DJ, Burckart GJ, Cressey TR, Mirochnick M, Best BM, van den Anker JN, Dallmann A. PMID: 32451908.
      View in: PubMed   Mentions:    Fields:    
    5. Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial. Lancet HIV. 2020 05; 7(5):e322-e331. João EC, Morrison RL, Shapiro DE, Chakhtoura N, Gouvèa MIS, de Lourdes B Teixeira M, Fuller TL, Mmbaga BT, Ngocho JS, Njau BN, Violari A, Mathiba R, Essack Z, Pilotto JHS, Moreira LF, Rolon MJ, Cahn P, Prommas S, Cressey TR, Chokephaibulkit K, Werarak P, Laimon L, Hennessy R, Frenkel LM, Anthony P, Best BM, Siberry GK, Mirochnick M. PMID: 32386720.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    6. Darunavir Pharmacokinetics With an Increased Dose During Pregnancy. J Acquir Immune Defic Syndr. 2020 Apr 01; 83(4):373-380. Eke AC, Stek AM, Wang J, Kreitchmann R, Shapiro DE, Smith E, Chakhtoura N, Capparelli EV, Mirochnick M, Best BM. PMID: 31923087.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Fosamprenavir with Ritonavir Pharmacokinetics during Pregnancy. Antimicrob Agents Chemother. 2020 03 24; 64(4). Eke AC, Wang J, Amin K, Shapiro DE, Stek A, Smith E, Chakhtoura N, Basar M, George K, Knapp KM, João EC, Rungruengthanakit K, Capparelli E, Burchett S, Mirochnick M, Best BM. PMID: 32015036.
      View in: PubMed   Mentions:    Fields:    
    8. Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm. J Pediatr. 2019 12; 215:107-117.e12. Tremoulet AH, Jain S, Jone PN, Best BM, Duxbury EH, Franco A, Printz B, Dominguez SR, Heizer H, Anderson MS, Glodé MP, He F, Padilla RL, Shimizu C, Bainto E, Pancheri J, Cohen HJ, Whitin JC, Burns JC. PMID: 31561960.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    9. Physiologically Based Pharmacokinetic Models to Predict Maternal Pharmacokinetics and Fetal Exposure to Emtricitabine and Acyclovir. J Clin Pharmacol. 2020 Feb; 60(2):240-255. Liu XI, Momper JD, Rakhmanina N, van den Anker JN, Green DJ, Burckart GJ, Best BM, Mirochnick M, Capparelli EV, Dallmann A. PMID: 31489678.
      View in: PubMed   Mentions: 2     Fields:    
    10. Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling. J Antimicrob Chemother. 2019 05 01; 74(5):1348-1356. Schalkwijk S, Ter Heine R, Colbers A, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Moltó J, Mirochnick M, Karlsson MO, Burger DM. PMID: 30715324.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults. Front Pediatr. 2019; 7:16. Hanan NJ, Paul ME, Huo Y, Kapetanovic S, Smith E, Siberry G, Brouwers P, Graham B, Johnston B, Capparelli EV, Best BM. PMID: 30788337.
      View in: PubMed   Mentions:
    12. Efavirenz pharmacokinetics during pregnancy and infant washout. Antivir Ther. 2019; 24(2):95-103. Kreitchmann R, Schalkwijk S, Best B, Wang J, Colbers A, Stek A, Shapiro D, Cressey T, Mirochnick M, Burger D. PMID: 30530925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease. Clin Pharmacokinet. 2018 12; 57(12):1593-1601. Vande Casteele N, Oyamada J, Shimizu C, Best BM, Capparelli EV, Tremoulet AH, Burns JC. PMID: 29623653.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV. AIDS. 2018 11 13; 32(17):2507-2516. Momper JD, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Badell ML, Acosta EP, Purswani M, Smith E, Chakhtoura N, Park K, Burchett S, Shapiro DE, Mirochnick M. PMID: 30134297.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    15. A Mechanism-Based Population Pharmacokinetic Analysis Assessing the Feasibility of Efavirenz Dose Reduction to 400 mg in Pregnant Women. Clin Pharmacokinet. 2018 11; 57(11):1421-1433. Schalkwijk S, Ter Heine R, Colbers AC, Huitema ADR, Denti P, Dooley KE, Capparelli E, Best BM, Cressey TR, Greupink R, Russel FGM, Mirochnick M, Burger DM. PMID: 29520730.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum. J Clin Pharmacol. 2019 03; 59(3):386-393. Eke AC, McCormack SA, Best BM, Stek AM, Wang J, Kreitchmann R, Shapiro D, Smith E, Mofenson LM, Capparelli EV, Mirochnick M. PMID: 30358179.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    17. Population Pharmacokinetics of Lopinavir/Ritonavir: Changes Across Formulations and Human Development From Infancy Through Adulthood. J Clin Pharmacol. 2018 12; 58(12):1604-1617. Yang J, Nikanjam M, Best BM, Pinto J, Chadwick EG, Daar ES, Havens PL, Rakhmanina N, Capparelli EV. PMID: 30252146.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk. Pediatrics. 2018 09; 142(3). Bertrand KA, Hanan NJ, Honerkamp-Smith G, Best BM, Chambers CD. PMID: 30150212.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    19. Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum. J Acquir Immune Defic Syndr. 2018 07 01; 78(3):308-313. Eke AC, Chakhtoura N, Kashuba A, Best BM, Sykes C, Wang J, Stek AM, Smith E, Calabrese S, Capparelli EV, Mirochnick M. PMID: 29528944.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Randomized Controlled Trial of Daily Text Messages to Support Adherence to Preexposure Prophylaxis in Individuals at Risk for Human Immunodeficiency Virus: The TAPIR Study. Clin Infect Dis. 2018 05 02; 66(10):1566-1572. Moore DJ, Jain S, Dubé MP, Daar ES, Sun X, Young J, Corado K, Ellorin E, Milam J, Collins D, Blumenthal J, Best BM, Anderson P, Haubrich R, Morris SR. PMID: 29228144.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    21. Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV. AIDS. 2018 03 27; 32(6):729-737. Mulligan N, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Buschur SL, Acosta EP, Smith E, Chakhtoura N, Burchett S, Mirochnick M. PMID: 29369162.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    22. A pilot study on clinical pharmacokinetics and preclinical pharmacodynamics of (+)-epicatechin on cardiometabolic endpoints. Food Funct. 2018 Jan 24; 9(1):307-319. Moreno-Ulloa A, Nájera-García N, Hernández M, Ramírez-Sánchez I, Taub PR, Su Y, Beltrán-Partida E, Ceballos G, Dugar S, Schreiner G, Best BM, Ciaraldi TP, Henry RR, Villarreal F. PMID: 29171848.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    23. Effect of a Dedicated Pharmacy Student Summer Research Program on Publication Rate. Am J Pharm Educ. 2017 Apr; 81(3):48. Brandl K, Adler D, Kelly C, Taylor P, Best BM. PMID: 28496268.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. An Interactive, Multifaceted Approach to Enhancing Pharmacy Students' Health Literacy Knowledge and Confidence. Am J Pharm Educ. 2017 Mar 25; 81(2):32. Mnatzaganian C, Fricovsky E, Best BM, Singh RF. PMID: 28381892.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Safety and Efficacy of Atorvastatin in Human Immunodeficiency Virus-infected Children, Adolescents and Young Adults With Hyperlipidemia. Pediatr Infect Dis J. 2017 01; 36(1):53-60. Melvin AJ, Montepiedra G, Aaron L, Meyer WA, Spiegel HM, Borkowsky W, Abzug MJ, Best BM, Crain MJ, Borum PR, Graham B, Anthony P, Shin K, Siberry GK. PMID: 27749649.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    26. Etravirine Pharmacokinetics in HIV-Infected Pregnant Women. Front Pharmacol. 2016; 7:239. Mulligan N, Schalkwijk S, Best BM, Colbers A, Wang J, Capparelli EV, Moltó J, Stek AM, Taylor G, Smith E, Hidalgo Tenorio C, Chakhtoura N, van Kasteren M, Fletcher CV, Mirochnick M, Burger D. PMID: 27540363.
      View in: PubMed   Mentions:
    27. Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. J Acquir Immune Defic Syndr. 2016 07 01; 72(3):289-96. Tran AH, Best BM, Stek A, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, George K, Cressey TR, Chakhtoura N, Smith E, Shapiro DE, Mirochnick M. PMID: 26918544.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    28. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 05; 48:70-5. Tremoulet AH, Jain S, Kim S, Newburger J, Arditi M, Franco A, Best B, Burns JC. PMID: 27080929.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCTClinical Trials
    29. Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women. J Acquir Immune Defic Syndr. 2015 Sep 01; 70(1):33-41. Stek A, Best BM, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, Cressey TR, Mofenson LM, Smith E, Shapiro D, Mirochnick M. PMID: 25950206.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    30. Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women. Clin Infect Dis. 2015 Nov 15; 61(10):1582-9. Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M. PMID: 26202768.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    31. Pharmacokinetics of tenofovir during pregnancy and postpartum. HIV Med. 2015 Sep; 16(8):502-11. Best BM, Burchett S, Li H, Stek A, Hu C, Wang J, Hawkins E, Byroads M, Watts DH, Smith E, Fletcher CV, Capparelli EV, Mirochnick M. PMID: 25959631.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    32. Raltegravir pharmacokinetics during pregnancy. J Acquir Immune Defic Syndr. 2014 Dec 01; 67(4):375-81. Watts DH, Stek A, Best BM, Wang J, Capparelli EV, Cressey TR, Aweeka F, Lizak P, Kreitchmann R, Burchett SK, Shapiro DE, Hawkins E, Smith E, Mirochnick M. PMID: 25162818.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    33. Alteration in cytochrome P450 3A4 activity as measured by a urine cortisol assay in HIV-1-infected pregnant women and relationship to antiretroviral pharmacokinetics. HIV Med. 2015 Mar; 16(3):176-83. Aweeka FT, Hu C, Huang L, Best BM, Stek A, Lizak P, Burchett SK, Read JS, Watts H, Mirochnick M, Capparelli EV. PMID: 25407158.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    34. Protecting the fetus against HIV infection: a systematic review of placental transfer of antiretrovirals. Clin Pharmacokinet. 2014 Nov; 53(11):989-1004. McCormack SA, Best BM. PMID: 25223699.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    35. Response to urine drug testing for oxycodone and its metabolites as a tool for drug-drug interactions. J Anal Toxicol. 2015 Jan-Feb; 39(1):80. Elder NM, Atayee RS, Best BM, Ma JD. PMID: 25288719.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy. J Antimicrob Chemother. 2015 Jan; 70(1):217-24. Cressey TR, Urien S, Capparelli EV, Best BM, Buranabanjasatean S, Limtrakul A, Rawangban B, Sabsanong P, Treluyer JM, Jourdain G, Stek A, Lallemant M, Mirochnick M. PMID: 25261418.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    37. Authors' reply. J Anal Toxicol. 2014 Sep; 38(7):463. Elder NM, Atayee RS, Best BM, Ma JD. PMID: 24986838.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Evaluation of concomitant methylphenidate and opioid use in patients with pain. J Anal Toxicol. 2014 Sep; 38(7):421-6. Jiang JY, Best BM, Morello CM, Atayee RS, Ma JD. PMID: 24907143.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Urinary hydrocodone and metabolite distributions in pain patients. J Anal Toxicol. 2014 Sep; 38(7):404-9. Barakat NH, Atayee RS, Best BM, Ma JD. PMID: 24836897.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Urine specimen detection of zolpidem use in patients with pain. J Anal Toxicol. 2014 Jul-Aug; 38(6):322-6. Mann LM, Atayee RS, Best BM, Morello CM, Ma JD. PMID: 24802157.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. Observations on hydrocodone and its metabolites in oral fluid specimens of the pain population: comparison with urine. J Opioid Manag. 2014 May-Jun; 10(3):177-86. Cao JM, Ma JD, Morello CM, Atayee RS, Best BM. PMID: 24944068.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Variability in metabolism of imipramine and desipramine using urinary excretion data. J Anal Toxicol. 2014 Jul-Aug; 38(6):368-74. Ramey K, Ma JD, Best BM, Atayee RS, Morello CM. PMID: 24782142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Naltrexone metabolism and concomitant drug concentrations in chronic pain patients. J Anal Toxicol. 2014 May; 38(4):212-7. Liu JC, Ma JD, Morello CM, Atayee RS, Best BM. PMID: 24659754.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Observation of improved adherence with frequent urine drug testing in patients with pain. J Opioid Manag. 2014 Mar-Apr; 10(2):111-8. Yee DA, Hughes MM, Guo AY, Barakat NH, Tse SA, Ma JD, Best BM, Atayee RS. PMID: 24715666.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    45. Observations of urinary oxycodone and metabolite distributions in pain patients. J Anal Toxicol. 2014 Apr; 38(3):129-34. Elder NM, Atayee RS, Best BM, Ma JD. PMID: 24523296.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. Obstetric Pharmacokinetic Dosing Studies are Urgently Needed. Front Pediatr. 2014; 2:9. McCormack SA, Best BM. PMID: 24575394.
      View in: PubMed   Mentions:
    47. Urinary diazepam metabolite distribution in a chronic pain population. J Anal Toxicol. 2014 Apr; 38(3):135-42. Luk S, Atayee RS, Ma JD, Best BM. PMID: 24500275.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    48. Factors affecting carisoprodol metabolism in pain patients using urinary excretion data. J Anal Toxicol. 2014 Apr; 38(3):122-8. Tse SA, Atayee RS, Ma JD, Best BM. PMID: 24488112.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Observations on the urine metabolic profile of codeine in pain patients. J Anal Toxicol. 2014 Mar; 38(2):86-91. Yee DA, Atayee RS, Best BM, Ma JD. PMID: 24396053.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    50. Monitoring oxycodone use in patients with chronic pain: analysis of oxycodone and metabolite excretion in saliva and urine. J Opioid Manag. 2014 Jan-Feb; 10(1):47-56. Moy KV, Ma JD, Morello CM, Atayee RS, Best BM. PMID: 24604569.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Randomized trial of central nervous system-targeted antiretrovirals for HIV-associated neurocognitive disorder. Clin Infect Dis. 2014 Apr; 58(7):1015-22. Ellis RJ, Letendre S, Vaida F, Haubrich R, Heaton RK, Sacktor N, Clifford DB, Best BM, May S, Umlauf A, Cherner M, Sanders C, Ballard C, Simpson DM, Jay C, McCutchan JA. PMID: 24352352.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    52. Impact of a first-year student pharmacist diabetes self-care education program. Am J Pharm Educ. 2013 Dec 16; 77(10):215. Morello CM, Neighbors M, Luu L, Kobayashi S, Mutrux B, Best BM. PMID: 24371339.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    53. Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. Pain Med. 2014 Mar; 15(3):355-63. Bordson SJ, Atayee RS, Ma JD, Best BM. PMID: 24308804.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. Factors impacting variability of the urinary normeperidine-to-meperidine metabolic ratio in patients with chronic pain. J Anal Toxicol. 2014 Jan-Feb; 38(1):1-7. Moy KV, Ma JD, Best BM, Atayee RS. PMID: 24133175.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    55. Urine specimen detection of concurrent nonprescribed medicinal and illicit drug use in patients prescribed buprenorphine. J Anal Toxicol. 2013 Nov-Dec; 37(9):636-41. Guo AY, Ma JD, Best BM, Atayee RS. PMID: 24080973.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    56. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol. 2013 Sep; 76(3):475-83. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M. PMID: 23305215.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    57. Pharmacokinetics of an increased atazanavir dose with and without tenofovir during the third trimester of pregnancy. J Acquir Immune Defic Syndr. 2013 May 01; 63(1):59-66. Kreitchmann R, Best BM, Wang J, Stek A, Caparelli E, Watts DH, Smith E, Shapiro DE, Rossi S, Burchett SK, Hawkins E, Byroads M, Cressey TR, Mirochnick M. PMID: 23392467.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    58. Etravirine in CSF is highly protein bound. J Antimicrob Chemother. 2013 May; 68(5):1161-8. Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S. PMID: 23335197.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    59. Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. J Antimicrob Chemother. 2013 Mar; 68(3):684-9. Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S. PMID: 23143899.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    60. Incidence of Kawasaki disease in northern European countries. Pediatr Int. 2012 Dec; 54(6):770-2. Salo E, Griffiths EP, Farstad T, Schiller B, Nakamura Y, Yashiro M, Uehara R, Best BM, Burns JC. PMID: 22726311.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    61. An active-learning assignment involving peer-to-peer presentations to improve pharmacy students' attitudes and knowledge of dietary supplements. Am J Pharm Educ. 2012 Aug 10; 76(6):113. Atayee RS, Singh RF, Best BM, Freedman BA, Morello CM. PMID: 22919089.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    62. Pharmacokinetic analysis of ziconotide (SNX-111), an intrathecal N-type calcium channel blocking analgesic, delivered by bolus and infusion in the dog. Neuromodulation. 2012 Nov-Dec; 15(6):508-19; discussion 519. Yaksh TL, de Kater A, Dean R, Best BM, Miljanich GP. PMID: 22748108.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    63. Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients. J Anal Toxicol. 2012 May; 36(4):239-49. Leimanis E, Best BM, Atayee RS, Pesce AJ. PMID: 22511698.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    64. Observations on the metabolism of morphine to hydromorphone in pain patients. J Anal Toxicol. 2012 May; 36(4):250-6. Hughes MM, Atayee RS, Best BM, Pesce AJ. PMID: 22511699.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    65. Relationship between the concentration of hydrocodone and its conversion to hydromorphone in chronic pain patients using urinary excretion data. J Anal Toxicol. 2012 May; 36(4):257-64. Barakat NH, Atayee RS, Best BM, Pesce AJ. PMID: 22511700.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    66. Evaluating the relationship between carisoprodol concentrations and meprobamate formation and inter-subject and intra-subject variability in urinary excretion data of pain patients. J Anal Toxicol. 2012 May; 36(4):221-31. Tse SA, Atayee RS, Best BM, Pesce AJ. PMID: 22511696.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Observations on the urine metabolic ratio of oxymorphone to oxycodone in pain patients. J Anal Toxicol. 2012 May; 36(4):232-8. Yee DA, Best BM, Atayee RS, Pesce AJ. PMID: 22511697.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    68. Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. AIDS. 2012 Apr 24; 26(7):890-3. Croteau D, Best BM, Letendre S, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Grant I. PMID: 22313954.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    69. Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir. J Acquir Immune Defic Syndr. 2012 Apr 01; 59(4):376-81. Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli EV, Ellis RJ, Grant I. PMID: 22217676.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    70. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):245-52. Cressey TR, Stek A, Capparelli E, Bowonwatanuwong C, Prommas S, Sirivatanapa P, Yuthavisuthi P, Neungton C, Huo Y, Smith E, Best BM, Mirochnick M. PMID: 22083071.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsCTClinical Trials
    71. Therapeutic amprenavir concentrations in cerebrospinal fluid. Antimicrob Agents Chemother. 2012 Apr; 56(4):1985-9. Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I. PMID: 22290964.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    72. Pharmacokinetics of lopinavir/ritonavir crushed versus whole tablets in children. J Acquir Immune Defic Syndr. 2011 Dec 01; 58(4):385-91. Best BM, Capparelli EV, Diep H, Rossi SS, Farrell MJ, Williams E, Lee G, van den Anker JN, Rakhmanina N. PMID: 21876444.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    73. Effect of pregnancy on emtricitabine pharmacokinetics. HIV Med. 2012 Apr; 13(4):226-35. Stek AM, Best BM, Luo W, Capparelli E, Burchett S, Hu C, Li H, Read JS, Jennings A, Barr E, Smith E, Rossi SS, Mirochnick M. PMID: 22129166.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    74. Increased incidence and severity of Kawasaki disease among Filipino-Americans in San Diego county. Pediatr Infect Dis J. 2011 Oct; 30(10):909-11. Tremoulet AH, Devera G, Best BM, Jimenez-Fernandez S, Sun X, Jain S, Burns JC. PMID: 21552184.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    75. Cardiovascular biomarkers in acute Kawasaki disease. Int J Cardiol. 2013 Mar 20; 164(1):58-63. Sato YZ, Molkara DP, Daniels LB, Tremoulet AH, Shimizu C, Kanegaye JT, Best BM, Snider JV, Frazer JR, Maisel A, Burns JC. PMID: 21777987.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    76. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):412-9. Mirochnick M, Best BM, Stek AM, Capparelli EV, Hu C, Burchett SK, Rossi SS, Hawkins E, Basar M, Smith E, Read JS. PMID: 21283017.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCellsCTClinical Trials
    77. Antiretroviral therapy adherence, medication use, and health care costs during 3 years of a community pharmacy medication therapy management program for Medi-Cal beneficiaries with HIV/AIDS. J Manag Care Pharm. 2011 Apr; 17(3):213-23. Hirsch JD, Gonzales M, Rosenquist A, Miller TA, Gilmer TP, Best BM. PMID: 21434698.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    78. Antiretroviral pharmacology: special issues regarding pregnant women and neonates. Clin Perinatol. 2010 Dec; 37(4):907-27, xi. Mirochnick M, Best BM, Clarke DF. PMID: 21078458.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    79. Medication therapy management services in community pharmacy: a pilot programme in HIV specialty pharmacies. J Eval Clin Pract. 2010 Dec; 16(6):1142-6. Rosenquist A, Best BM, Miller TA, Gilmer TP, Hirsch JD. PMID: 21143346.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    80. Efavirenz concentrations in CSF exceed IC50 for wild-type HIV. J Antimicrob Chemother. 2011 Feb; 66(2):354-7. Best BM, Koopmans PP, Letendre SL, Capparelli EV, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I. PMID: 21098541.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    81. Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1. Antimicrob Agents Chemother. 2010 Dec; 54(12):5156-60. Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I. PMID: 20876368.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    82. Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2010 Aug; 54(4):381-8. Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV. PMID: 20632458.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    83. Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance. Hum Immunol. 2010 Sep; 71(9):865-73. Fury W, Tremoulet AH, Watson VE, Best BM, Shimizu C, Hamilton J, Kanegaye JT, Wei Y, Kao C, Mellis S, Lin C, Burns JC. PMID: 20600450.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    84. Enhancing an introductory Pharmacy Practice Experience at free medical clinics. Int J Pharm Pract. 2010 Feb; 18(1):51-7. Morello CM, Singh RF, Chen KJ, Best BM. PMID: 20405596.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    85. Variability of transdermal fentanyl metabolism and excretion in pain patients. J Opioid Manag. 2010 Jan-Feb; 6(1):29-39. Cole JM, Best BM, Pesce AJ. PMID: 20297612.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    86. Lopinavir protein binding in HIV-1-infected pregnant women. HIV Med. 2010 Apr; 11(4):232-8. Aweeka FT, Stek A, Best BM, Hu C, Holland D, Hermes A, Burchett SK, Read J, Mirochnick M, Capparelli EV. PMID: 20002783.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    87. Periungual desquamation in patients with Kawasaki disease. Pediatr Infect Dis J. 2009 Jun; 28(6):538-9. Wang S, Best BM, Burns JC. PMID: 19483521.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    88. Should antiretroviral therapy for HIV infection be tailored for intracerebral penetration? Neth J Med. 2009 Jun; 67(6):206-11. Koopmans PP, Ellis R, Best BM, Letendre S. PMID: 19749389.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    89. Pyuria associated with acute Kawasaki disease and fever from other causes. Pediatr Infect Dis J. 2009 May; 28(5):440-3. Shike H, Kanegaye JT, Best BM, Pancheri J, Burns JC. PMID: 19319019.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    90. Recognition of a Kawasaki disease shock syndrome. Pediatrics. 2009 May; 123(5):e783-9. Kanegaye JT, Wilder MS, Molkara D, Frazer JR, Pancheri J, Tremoulet AH, Watson VE, Best BM, Burns JC. PMID: 19403470.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    91. Low atazanavir concentrations in cerebrospinal fluid. AIDS. 2009 Jan 02; 23(1):83-7. Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I. PMID: 19050389.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCTClinical Trials
    92. Evaluation of the first year of a pilot program in community pharmacy: HIV/AIDS medication therapy management for Medi-Cal beneficiaries. J Manag Care Pharm. 2009 Jan-Feb; 15(1):32-41. Hirsch JD, Rosenquist A, Best BM, Miller TA, Gilmer TP. PMID: 19125548.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    93. Lopinavir exposure with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2008 Dec 15; 49(5):485-91. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Holland DT, Smith E, Gaddipati S, Read JS. PMID: 18989231.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    94. Development of an ambulatory palliative care pharmacist practice. J Palliat Med. 2008 Oct; 11(8):1077-82. Atayee RS, Best BM, Daniels CE. PMID: 18980446.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    95. Pharmacokinetics of new 625 mg nelfinavir formulation during pregnancy and postpartum. HIV Med. 2008 Nov; 9(10):875-82. Read JS, Best BM, Stek AM, Hu C, Capparelli EV, Holland DT, Burchett SK, Smith ME, Sheeran EC, Shearer WT, Febo I, Mirochnick M. PMID: 18795962.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    96. Infliximab treatment of intravenous immunoglobulin-resistant Kawasaki disease. J Pediatr. 2008 Dec; 153(6):833-8. Burns JC, Best BM, Mejias A, Mahony L, Fixler DE, Jafri HS, Melish ME, Jackson MA, Asmar BI, Lang DJ, Connor JD, Capparelli EV, Keen ML, Mamun K, Keenan GF, Ramilo O. PMID: 18672254.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    97. Efavirenz--still first-line king? Expert Opin Drug Metab Toxicol. 2008 Jul; 4(7):965-72. Best BM, Goicoechea M. PMID: 18624683.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    98. Implications of gender and pregnancy for antiretroviral drug dosing. Curr Opin HIV AIDS. 2008 May; 3(3):277-82. Best BM, Capparelli EV. PMID: 19372979.
      View in: PubMed   Mentions: 3     Fields:    
    99. Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Med. 2008 Apr; 9(4):214-20. Capparelli EV, Aweeka F, Hitti J, Stek A, Hu C, Burchett SK, Best B, Smith E, Read JS, Watts H, Nachman S, Thorpe EM, Spector SA, Jimenez E, Shearer WT, Foca M, Mirochnick M. PMID: 18366444.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    100. Resistance to intravenous immunoglobulin in children with Kawasaki disease. J Pediatr. 2008 Jul; 153(1):117-21. Tremoulet AH, Best BM, Song S, Wang S, Corinaldesi E, Eichenfield JR, Martin DD, Newburger JW, Burns JC. PMID: 18571548.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    101. Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy. J Infect Dis. 2008 Jan 01; 197(1):102-8. Goicoechea M, Liu S, Best B, Sun S, Jain S, Kemper C, Witt M, Diamond C, Haubrich R, Louie S. PMID: 18171292.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    102. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol. 2008 Jan; 65(1):65-70. Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ. PMID: 18195140.
      View in: PubMed   Mentions: 305     Fields:    Translation:Humans
    103. A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients. J Acquir Immune Defic Syndr. 2007 Dec 01; 46(4):433-42. Best BM, Goicoechea M, Witt MD, Miller L, Daar ES, Diamond C, Tilles JG, Kemper CA, Larsen R, Holland DT, Sun S, Jain S, Wagner G, Capparelli EV, McCutchan JA, Haubrich RH. PMID: 17786128.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    104. Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all? Expert Opin Pharmacother. 2007 Feb; 8(3):371-82. Goicoechea M, Best B. PMID: 17266471.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    105. The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system. J Neuroimmune Pharmacol. 2007 Mar; 2(1):120-7. Letendre SL, Marquie-Beck J, Ellis RJ, Woods SP, Best B, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson D, Alexander TJ, Durelle J, Heaton R, Grant I. PMID: 18040835.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    106. Therapeutic ritonavir-boosted atazanavir plasma concentration and concurrent omeprazole use. AIDS. 2006 Oct 24; 20(16):2127-8. Goicoechea M, Best B, Capparelli E, Caperna J, Ballard C, Haubrich R. PMID: 17053363.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    107. Reduced lopinavir exposure during pregnancy. AIDS. 2006 Oct 03; 20(15):1931-9. Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. PMID: 16988514.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCellsCTClinical Trials
    108. Concurrent use of efavirenz and oxcarbazepine may not affect efavirenz plasma concentrations. Clin Infect Dis. 2006 Jul 01; 43(1):116-7. Goicoechea M, Best B, Capparelli E, Haubrich R. PMID: 16758435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    109. Failure of modified directly observed therapy combined with therapeutic drug monitoring to enhance antiretroviral adherence in a patient with major depression. AIDS Patient Care STDS. 2006 Apr; 20(4):233-7. Goicoechea M, Best B, Seefried E, Wagner G, Capparelli E, Haubrich R. PMID: 16623621.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    110. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006 Feb 28; 20(4):553-60. Best BM, Mirochnick M, Capparelli EV, Stek A, Burchett SK, Holland DT, Read JS, Smith E, Hu C, Spector SA, Connor JD. PMID: 16470119.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    111. Tipranavir: a protease inhibitor for multi-drug resistant HIV-1. Expert Opin Investig Drugs. 2006 Jan; 15(1):59-70. Best B, Haubrich R. PMID: 16370934.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    112. Pharmacokinetic and tolerability assessment of a pediatric oral formulation of pentoxifylline in kawasaki disease. Curr Ther Res Clin Exp. 2003 Feb; 64(2):96-115. Best BM, Burns JC, DeVincenzo J, Phelps SJ, Blumer JL, Wilson JT, Capparelli EV, Connor JD. PMID: 24944359.
      View in: PubMed   Mentions: 1     Fields:    
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