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Dan Zhou

Title(s)Project Scientist, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emaild2zhou@ucsd.edu
ORCID ORCID Icon0000-0001-6401-9040 Additional info
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster. G3 (Bethesda). 2021 Feb 12. PMID: 33576765.
      View in: PubMed   Mentions:    Fields:    
    2. Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster. Nat Commun. 2021 02 12; 12(1):997. PMID: 33579965.
      View in: PubMed   Mentions: 1     Fields:    
    3. Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-?B kinase subunit ß-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769. Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Intermittent Hypoxia and Hypercapnia Reproducibly Change the Gut Microbiome and Metabolome across Rodent Model Systems. mSystems. 2019 Mar-Apr; 4(2). Tripathi A, Xu ZZ, Xue J, Poulsen O, Gonzalez A, Humphrey G, Meehan MJ, Melnik AV, Ackermann G, Zhou D, Malhotra A, Haddad GG, Dorrestein PC, Knight R. PMID: 31058230.
      View in: PubMed   Mentions:
    5. High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. PLoS One. 2019; 14(3):e0213474. Stobdan T, Sahoo D, Azad P, Hartley I, Heinrichsen E, Zhou D, Haddad GG. PMID: 30861021.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    6. Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders. Eur J Hum Genet. 2019 01; 27(1):150-159. Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 30254217.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia. J Mol Med (Berl). 2018 09; 96(9):975-982. Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG. PMID: 30069745.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice. Physiol Genomics. 2018 10 01; 50(10):846-861. Xue J, Zhou D, Poulsen O, Hartley I, Imamura T, Xie EX, Haddad GG. PMID: 30029588.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems. 2018 May-Jun; 3(3). Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG. PMID: 29896566.
      View in: PubMed   Mentions:
    10. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 29029226.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    11. Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. PMID: 28678519.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    12. High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG. PMID: 28951950.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    13. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 11 14; 213(12):2729-2744. PMID: 27821551.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits. BMC Biol. 2015 Nov 27; 13:101. PMID: 26614097.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. PMID: 26576852.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    16. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. PMID: 26240367.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    17. Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Neuroscience. 2015 Mar 12; 288:187-99. PMID: 25559931.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403-12. PMID: 25362634.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    19. Wnt pathway activation increases hypoxia tolerance during development. PLoS One. 2014; 9(8):e103292. PMID: 25093834.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36. PMID: 24555826.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures. PLoS One. 2013; 8(10):e77859. PMID: 24205000.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    22. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. PMID: 24069262.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    23. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62. PMID: 23954164.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    24. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet. 2013; 14:25-43. PMID: 23808366.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    25. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013; 14 Suppl 3:S9. PMID: 23819581.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    26. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda). 2012 Oct; 2(10):1169-78. PMID: 23050227.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    27. Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster. PLoS One. 2012; 7(9):e45344. PMID: 23028948.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One. 2012; 7(5):e36801. PMID: 22574227.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. Tests of selection in pooled case-control data: an empirical study. Front Genet. 2011; 2:83. PMID: 22303377.
      View in: PubMed   Mentions:
    30. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. . 2011 Sep; 301(3):R727-45. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. PMID: 21677276.
      View in: PubMed   Mentions:
    31. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. PMID: 21262834.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    32. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
      View in: PubMed   Mentions:
    33. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem. 2011 Feb 25; 286(8):6211-8. Zhao HW, Zhou D, Haddad GG. PMID: 21148307.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    34. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. Zhao HW, Zhou D, Nizet V, Haddad GG. PMID: 20668515.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy. Physiol Genomics. 2010 Aug; 42(3):374-83. Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad GG. PMID: 20460605.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    36. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 09; 3:91. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD. PMID: 19740440.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    37. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 2009 Sep; 66(3):239-47. Zhou D, Visk DW, Haddad GG. PMID: 19542900.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. PLoS One. 2009; 4(4):e5371. Azad P, Zhou D, Russo E, Haddad GG. PMID: 19401761.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    39. DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms. J Neurochem. 2009 Feb; 108(3):835-46. Yao H, Felfly H, Wang J, Zhou D, Haddad GG. PMID: 19077053.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    40. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 2008 Oct; 4(10):e1000221. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad GG. PMID: 18927626.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    41. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics. 2008 Feb 19; 32(3):370-9. Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG. PMID: 18056785.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Modulation of hSlo BK current inactivation by fatty acid esters of CoA. J Neurochem. 2008 Mar; 104(5):1394-403. Sun X, Yao H, Zhou D, Gu X, Haddad GG. PMID: 18005338.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    43. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Neuroscience. 2008 Jan 24; 151(2):410-8. Ruffin VA, Gu XQ, Zhou D, Douglas RM, Sun X, Trouth CO, Haddad GG. PMID: 18082331.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    44. Role of transporters and ion channels in neuronal injury under hypoxia. . 2008 Feb; 294(2):R451-7. Xue J, Zhou D, Yao H, Haddad GG. PMID: 17977915.
      View in: PubMed   Mentions:
    45. Experimental selection for Drosophila survival in extremely low O(2) environment. PLoS One. 2007 May 30; 2(5):e490. Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, White KP, Haddad GG. PMID: 17534440.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    46. Hypoxia increases BK channel activity in the inner mitochondrial membrane. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):311-6. Gu XQ, Siemen D, Parvez S, Cheng Y, Xue J, Zhou D, Sun X, Jonas EA, Haddad GG. PMID: 17481584.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    47. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. . 2007 Jun; 292(6):R2406-16. Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD, Haddad GG. PMID: 17289818.
      View in: PubMed   Mentions:
    48. Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid. J Neurophysiol. 2007 Jan; 97(1):62-9. Sun X, Zhou D, Zhang P, Moczydlowski EG, Haddad GG. PMID: 17021030.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    49. Effect of carbon dioxide on neonatal mouse lung: a genomic approach. J Appl Physiol (1985). 2006 Dec; 101(6):1556-64. Li G, Zhou D, Vicencio AG, Ryu J, Xue J, Kanaan A, Gavrialov O, Haddad GG. PMID: 16888043.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    50. Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia. Physiol Genomics. 2005 Aug 11; 22(3):292-307. Fan C, Iacobas DA, Zhou D, Chen Q, Lai JK, Gavrialov O, Haddad GG. PMID: 15928208.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    51. Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain. Physiol Genomics. 2004 Aug 11; 18(3):331-9. Zhou D, Xue J, Gavrialov O, Haddad GG. PMID: 15306696.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. Expression of Na+/H+ and HCO3- -dependent transporters in Na+/H+ exchanger isoform 1 null mutant mouse brain. Neuroscience. 2003; 122(1):37-46. Xue J, Douglas RM, Zhou D, Lim JY, Boron WF, Haddad GG. PMID: 14596847.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    53. CB1 cannabinoid receptor-mediated tyrosine phosphorylation of focal adhesion kinase-related non-kinase. FEBS Lett. 2002 Aug 14; 525(1-3):164-8. Zhou D, Song ZH. PMID: 12163181.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    54. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Mol Endocrinol. 2002 Jul; 16(7):1511-23. Apostolakis EM, Ramamurphy M, Zhou D, Oñate S, O'Malley BW. PMID: 12089347.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    55. CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells. J Neurosci Res. 2001 Aug 15; 65(4):346-53. Zhou D, Song ZH. PMID: 11494371.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    56. Distribution of D(5) dopamine receptor mRNA in rat ventromedial hypothalamic nucleus. Biochem Biophys Res Commun. 1999 Dec 20; 266(2):556-9. Zhou D, Apostolakis EM, O'Malley BW. PMID: 10600540.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    57. Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat. J Neurosci Res. 1998 Oct 01; 54(1):109-16. Zhou D, Grecksch G, Becker A, Frank C, Pilz J, Huether G. PMID: 9778154.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    58. Influence of olfactory bulbectomy and subsequent imipramine treatment on 5-hydroxytryptaminergic presynapses in the rat frontal cortex: behavioural correlates. Br J Pharmacol. 1997 Dec; 122(8):1725-31. Grecksch G, Zhou D, Franke C, Schröder U, Sabel B, Becker A, Huether G. PMID: 9422820.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    59. No evidence for a physiological coupling between melatonin and glucocorticoids. Psychopharmacology (Berl). 1997 Oct; 133(4):313-22. Hajak G, Rodenbeck A, Ehrenthal HD, Leonard S, Wedekind D, Sengos G, Zhou D, Huether G. PMID: 9372529.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    60. Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex. Biol Psychiatry. 1997 Jun 15; 41(12):1174-80. Huether G, Zhou D, Schmidt S, Wiltfang J, Rüther E. PMID: 9171908.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    61. Long-term modulation of presynaptic 5-HT-output: experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density. J Neural Transm (Vienna). 1997; 104(10):993-1004. Huether G, Zhou D, Rüther E. PMID: 9503252.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    62. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners. J Neural Transm (Vienna). 1997; 104(8-9):771-94. Huether G, Zhou D, Rüther E. PMID: 9451711.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    63. Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. J Neurochem. 1996 Aug; 67(2):656-61. Zhou D, Huether G, Wiltfang J, Hajak G, Rüther E. PMID: 8764592.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    64. Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine. J Neural Transm (Vienna). 1996; 103(12):1381-95. Zhou D, Schreinert M, Pilz J, Huether G. PMID: 9029405.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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