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Dan Zhou

TitleAssociate Project Scientist
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0735
La Jolla CA 92093
Phone858-822-6889
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG. Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems. 2018 May-Jun; 3(3). PMID: 29896566.
      View in: PubMed
    2. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168. PMID: 29029226.
      View in: PubMed
    3. Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG. Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. PMID: 28678519.
      View in: PubMed
    4. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG. High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282. PMID: 28951950.
      View in: PubMed
    5. Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG. Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 Nov 14; 213(12):2729-2744. PMID: 27821551.
      View in: PubMed
    6. Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad GG, Korol AB. Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits. BMC Biol. 2015 Nov 27; 13:101. PMID: 26614097; PMCID: PMC4661966.
      View in: PubMed, PubMed Central
    7. Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. PMID: 26576852; PMCID: PMC4866538.
      View in: PubMed, PubMed Central
    8. Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. PMID: 26240367; PMCID: PMC4547246.
      View in: PubMed, PubMed Central
    9. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG. Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Neuroscience. 2015 Mar 12; 288:187-99. PMID: 25559931; PMCID: PMC4323892.
      View in: PubMed, PubMed Central
    10. Ronen R, Zhou D, Bafna V, Haddad GG. The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403-12. PMID: 25362634; PMCID: PMC4280153.
      View in: PubMed, PubMed Central
    11. Gersten M, Zhou D, Azad P, Haddad GG, Subramaniam S. Wnt pathway activation increases hypoxia tolerance during development. PLoS One. 2014; 9(8):e103292. PMID: 25093834; PMCID: PMC4122365.
      View in: PubMed, PubMed Central
    12. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36. PMID: 24555826; PMCID: PMC4054780.
      View in: PubMed, PubMed Central
    13. Hartley I, Elkhoury FF, Heon Shin J, Xie B, Gu X, Gao Y, Zhou D, Haddad GG. Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures. PLoS One. 2013; 8(10):e77859. PMID: 24205000; PMCID: PMC3808424.
      View in: PubMed, PubMed Central
    14. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. PMID: 24069262; PMCID: PMC3771901.
      View in: PubMed, PubMed Central
    15. Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62. PMID: 23954164; PMCID: PMC3769925.
      View in: PubMed, PubMed Central
    16. Zhou D, Haddad GG. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet. 2013; 14:25-43. PMID: 23808366.
      View in: PubMed
    17. Xie L, Ng C, Ali T, Valencia R, Ferreira BL, Xue V, Tanweer M, Zhou D, Haddad GG, Bourne PE, Xie L. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013; 14 Suppl 3:S9. PMID: 23819581; PMCID: PMC3665574.
      View in: PubMed, PubMed Central
    18. Azad P, Zhou D, Zarndt R, Haddad GG. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda). 2012 Oct; 2(10):1169-78. PMID: 23050227; PMCID: PMC3464109.
      View in: PubMed, PubMed Central
    19. Perkins G, Hsiao YH, Yin S, Tjong J, Tran MT, Lau J, Xue J, Liu S, Ellisman MH, Zhou D. Ultrastructural modifications in the mitochondria of hypoxia-adapted Drosophila melanogaster. PLoS One. 2012; 7(9):e45344. PMID: 23028948; PMCID: PMC3446896.
      View in: PubMed, PubMed Central
    20. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, Zhou D. Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One. 2012; 7(5):e36801. PMID: 22574227; PMCID: PMC3344937.
      View in: PubMed, PubMed Central
    21. Udpa N, Zhou D, Haddad GG, Bafna V. Tests of selection in pooled case-control data: an empirical study. Front Genet. 2011; 2:83. PMID: 22303377; PMCID: PMC3268381.
      View in: PubMed, PubMed Central
    22. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. PMID: 21677276; PMCID: PMC3174756.
      View in: PubMed, PubMed Central
    23. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. PMID: 21262834; PMCID: PMC3038716.
      View in: PubMed, PubMed Central
    24. Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). PMID: 24348887.
      View in: PubMed
    25. Zhao HW, Zhou D, Haddad GG. Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem. 2011 Feb 25; 286(8):6211-8. PMID: 21148307; PMCID: PMC3057857.
      View in: PubMed, PubMed Central
    26. Zhao HW, Zhou D, Nizet V, Haddad GG. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. PMID: 20668515; PMCID: PMC2909141.
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    27. Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad GG. Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy. Physiol Genomics. 2010 Aug; 42(3):374-83. PMID: 20460605; PMCID: PMC2929882.
      View in: PubMed, PubMed Central
    28. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD. Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 09; 3:91. PMID: 19740440; PMCID: PMC2749811.
      View in: PubMed, PubMed Central
    29. Zhou D, Visk DW, Haddad GG. Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 2009 Sep; 66(3):239-47. PMID: 19542900.
      View in: PubMed
    30. Azad P, Zhou D, Russo E, Haddad GG. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. PLoS One. 2009; 4(4):e5371. PMID: 19401761; PMCID: PMC2670512.
      View in: PubMed, PubMed Central
    31. Yao H, Felfly H, Wang J, Zhou D, Haddad GG. DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms. J Neurochem. 2009 Feb; 108(3):835-46. PMID: 19077053; PMCID: PMC2782475.
      View in: PubMed, PubMed Central
    32. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad GG. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 2008 Oct; 4(10):e1000221. PMID: 18927626; PMCID: PMC2556400.
      View in: PubMed, PubMed Central
    33. Zhou D, Wang J, Zapala MA, Xue J, Schork NJ, Haddad GG. Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death. Physiol Genomics. 2008 Feb 19; 32(3):370-9. PMID: 18056785.
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    34. Sun X, Yao H, Zhou D, Gu X, Haddad GG. Modulation of hSlo BK current inactivation by fatty acid esters of CoA. J Neurochem. 2008 Mar; 104(5):1394-403. PMID: 18005338.
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    35. Ruffin VA, Gu XQ, Zhou D, Douglas RM, Sun X, Trouth CO, Haddad GG. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Neuroscience. 2008 Jan 24; 151(2):410-8. PMID: 18082331.
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    36. Xue J, Zhou D, Yao H, Haddad GG. Role of transporters and ion channels in neuronal injury under hypoxia. Am J Physiol Regul Integr Comp Physiol. 2008 Feb; 294(2):R451-7. PMID: 17977915.
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    37. Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, White KP, Haddad GG. Experimental selection for Drosophila survival in extremely low O(2) environment. PLoS One. 2007 May 30; 2(5):e490. PMID: 17534440; PMCID: PMC1871610.
      View in: PubMed, PubMed Central
    38. Gu XQ, Siemen D, Parvez S, Cheng Y, Xue J, Zhou D, Sun X, Jonas EA, Haddad GG. Hypoxia increases BK channel activity in the inner mitochondrial membrane. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):311-6. PMID: 17481584.
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    39. Xue J, Zhou D, Yao H, Gavrialov O, McConnell MJ, Gelb BD, Haddad GG. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2406-16. PMID: 17289818.
      View in: PubMed
    40. Sun X, Zhou D, Zhang P, Moczydlowski EG, Haddad GG. Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid. J Neurophysiol. 2007 Jan; 97(1):62-9. PMID: 17021030.
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    41. Li G, Zhou D, Vicencio AG, Ryu J, Xue J, Kanaan A, Gavrialov O, Haddad GG. Effect of carbon dioxide on neonatal mouse lung: a genomic approach. J Appl Physiol (1985). 2006 Dec; 101(6):1556-64. PMID: 16888043.
      View in: PubMed
    42. Fan C, Iacobas DA, Zhou D, Chen Q, Lai JK, Gavrialov O, Haddad GG. Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia. Physiol Genomics. 2005 Aug 11; 22(3):292-307. PMID: 15928208; PMCID: PMC2856928.
      View in: PubMed, PubMed Central
    43. Zhou D, Xue J, Gavrialov O, Haddad GG. Na+/H+ exchanger 1 deficiency alters gene expression in mouse brain. Physiol Genomics. 2004 Aug 11; 18(3):331-9. PMID: 15306696.
      View in: PubMed
    44. Xue J, Douglas RM, Zhou D, Lim JY, Boron WF, Haddad GG. Expression of Na+/H+ and HCO3- -dependent transporters in Na+/H+ exchanger isoform 1 null mutant mouse brain. Neuroscience. 2003; 122(1):37-46. PMID: 14596847.
      View in: PubMed
    45. Zhou D, Song ZH. CB1 cannabinoid receptor-mediated tyrosine phosphorylation of focal adhesion kinase-related non-kinase. FEBS Lett. 2002 Aug 14; 525(1-3):164-8. PMID: 12163181.
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    46. Apostolakis EM, Ramamurphy M, Zhou D, Oñate S, O'Malley BW. Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice. Mol Endocrinol. 2002 Jul; 16(7):1511-23. PMID: 12089347.
      View in: PubMed
    47. Zhou D, Song ZH. CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells. J Neurosci Res. 2001 Aug 15; 65(4):346-53. PMID: 11494371.
      View in: PubMed
    48. Zhou D, Apostolakis EM, O'Malley BW. Distribution of D(5) dopamine receptor mRNA in rat ventromedial hypothalamic nucleus. Biochem Biophys Res Commun. 1999 Dec 20; 266(2):556-9. PMID: 10600540.
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    49. Zhou D, Grecksch G, Becker A, Frank C, Pilz J, Huether G. Serotonergic hyperinnervation of the frontal cortex in an animal model of depression, the bulbectomized rat. J Neurosci Res. 1998 Oct 01; 54(1):109-16. PMID: 9778154.
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    50. Grecksch G, Zhou D, Franke C, Schröder U, Sabel B, Becker A, Huether G. Influence of olfactory bulbectomy and subsequent imipramine treatment on 5-hydroxytryptaminergic presynapses in the rat frontal cortex: behavioural correlates. Br J Pharmacol. 1997 Dec; 122(8):1725-31. PMID: 9422820.
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    51. Hajak G, Rodenbeck A, Ehrenthal HD, Leonard S, Wedekind D, Sengos G, Zhou D, Huether G. No evidence for a physiological coupling between melatonin and glucocorticoids. Psychopharmacology (Berl). 1997 Oct; 133(4):313-22. PMID: 9372529.
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    52. Huether G, Zhou D, Schmidt S, Wiltfang J, Rüther E. Long-term food restriction down-regulates the density of serotonin transporters in the rat frontal cortex. Biol Psychiatry. 1997 Jun 15; 41(12):1174-80. PMID: 9171908.
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    53. Huether G, Zhou D, Rüther E. Long-term modulation of presynaptic 5-HT-output: experimentally induced changes in cortical 5-HT-transporter density, tryptophan hydroxylase content and 5-HT innervation density. J Neural Transm (Vienna). 1997; 104(10):993-1004. PMID: 9503252.
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    54. Huether G, Zhou D, Rüther E. Causes and consequences of the loss of serotonergic presynapses elicited by the consumption of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") and its congeners. J Neural Transm (Vienna). 1997; 104(8-9):771-94. PMID: 9451711.
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    55. Zhou D, Huether G, Wiltfang J, Hajak G, Rüther E. Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. J Neurochem. 1996 Aug; 67(2):656-61. PMID: 8764592.
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    56. Zhou D, Schreinert M, Pilz J, Huether G. Rat strain differences in the vulnerability of serotonergic nerve endings to neurotoxic damage by p-chloroamphetamine. J Neural Transm (Vienna). 1996; 103(12):1381-95. PMID: 9029405.
      View in: PubMed
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