Olivier George

Title(s)Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-3700-5003 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Bordeaux, Bordeaux, France PhD2004Neuroscience and Neuropharmacology
    University of Bordeaux, Bordeaux, FranceBS/MS2001Neuroscience and Neuropharmacology
    Collapse Awards and Honors
    American College of Neuropsychopharmacology2020Member
    College on Problems of Drug and Dependence2019Member
    UC San Diego Altman Clinical and Translational Research Institute2019General Member
    3rd International meeting on Steroids and Nervous System2003Young Researcher Travel Award
    French Ministry of Education and Research 2001Doctoral Training Merit Award (MENRT)
    University of Bordeaux2000Predoctoral Merit Award

    Collapse Overview 
    Collapse Overview
    Olivier George, Ph.D. is a Professor at the University of California San Diego, School of Medicine in the department of Psychiatry. He serves as the Co-Director of the Animal Core of the Scripps Research Alcohol Research Center, and Director of the Cocaine and Oxycodone Biobanks.
    Dr. George received his Ph.D. from the University of Bordeaux (France) where he worked with Drs. Le Moal, Piazza and Mayo on the role of cholinergic neurons in age-related sleep and memory impairments. He went on to conduct postdoctoral work on animal models of addiction at The Scripps Research Institute in La Jolla with Dr. Koob, before joining the faculty in 2013. He has studied alcohol, nicotine and drug addiction for more than 15 years, starting with his postdoctoral studies that were the first to identify the role of corticotropin releasing factor in escalation of nicotine self-administration and demonstrating that escalation of cocaine, methamphetamine and alcohol intake produces a dysfunction of the prefrontal cortex leading to cognitive impairment.
    Dr. George has made several breakthrough discoveries including identifying the neuronal ensembles of alcohol and nicotine addiction and discovering a novel neuronal population that drives negative emotional states in nicotine addiction. Dr. George has also pioneered the development of novel animal models of nicotine, opioid and alcohol addiction using electronic cigarette vapor self-administration. His recent work focuses on unveiling the genetic basis of addiction and identifying brain-wide functional architecture remodeling in animal models of drug addiction using single-cell whole brain imaging. His studies span multiple levels of approaches from molecular to integrated systems using state-of-the-art animal models of addiction with strong translational relevance. Using these approaches, he has contributed to the development of several Investigational New Drugs and hold several patents.
    Dr. GEorge has given over 120 talks to audiences of all levels, from high school, undergraduate and graduate students, to the general public and scientific colleagues in the field. Dr. George has published more than 70 papers in peer-reviewed journals. His work is supported by the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol and Alcoholism (NIAAA), the Tobacco-Related Disease Research Program (TRDRP).
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    Collapse Research 
    Collapse Research Activities and Funding
    Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsiveOxycodone Intake in Outbred Rats
    NIH U01DA044451Apr 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Neurobehavioral effects of nicotine e-cig self-administration in rats
    TRDRP 27IR-0047Apr 1, 2018 - Mar 31, 2021
    Role: PI
    Neuronal ensembles of compulsive alcohol drinking
    NIH R01AA026081Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake inRats
    NIH U01DA043799Apr 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Effect of Exposure to Nicotine Vapor on the Vulnerability to Nicotine Dependence
    NIH R21DA036691Sep 15, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Alcohol Vapor Self-Administration in Rats
    NIH R01AA022977May 1, 2014 - Jun 30, 2024
    Role: Principal Investigator
    The Role of Brain Stress Systems in the Prefrontal Cortex in Compulsive Drinking
    NIH R01AA020608Aug 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Neuropharmacology of Ethanol Reinforcement
    NIH R01AA008459Apr 1, 1990 - Apr 30, 2015
    Role: Principal Investigator
    Neuronal Substrates of Cocaine Reward
    NIH R01DA004398Apr 1, 1987 - Mar 31, 2016
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Are we compulsively chasing rainbows? Neuropsychopharmacology. 2022 Nov; 47(12):2013-2015. George O, Ahmed SH, Gilpin NW. PMID: 35982236; PMCID: PMC9556748.
      View in: PubMed   Mentions:
    2. Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats. Addict Neurosci. 2022 Sep; 3. Aldridge GM, Zarin TA, Brandner AJ, George O, Gilpin NW, Repunte-Canonigo V, Sanna PP, Koob GF, Vendruscolo LF, Schmeichel BE. PMID: 35965958; PMCID: PMC9365098.
      View in: PubMed   Mentions:
    3. Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Front Neurosci. 2022; 16:858427. Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. PMID: 35651629; PMCID: PMC9149415.
      View in: PubMed   Mentions:
    4. Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. Front Behav Neurosci. 2022; 16:832899. Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. PMID: 35316955; PMCID: PMC8934439.
      View in: PubMed   Mentions:
    5. Microstructural meal pattern analysis reveals a paradoxical acute increase in food intake after nicotine despite its long-term anorexigenic effects. Psychopharmacology (Berl). 2022 Mar; 239(3):807-818. Shankar K, Ambroggi F, George O. PMID: 35129671; PMCID: PMC8891107.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. Eur J Neurosci. 2022 02; 55(3):714-724. Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. PMID: 34963197.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. Neurosci Biobehav Rev. 2022 01; 132:730-756. Bowen MT, George O, Muskiewicz DE, Hall FS. PMID: 34839930; PMCID: PMC8892842.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Characterization of the Brain Functional Architecture of Psychostimulant Withdrawal Using Single-Cell Whole-Brain Imaging. eNeuro. 2021 Nov-Dec; 8(6). Kimbrough A, Kallupi M, Smith LC, Simpson S, Collazo A, George O. PMID: 34580158; PMCID: PMC8570684.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats. Brain Stimul. 2022 Jan-Feb; 15(1):13-22. Kallupi M, Kononoff J, Melas PA, Qvist JS, de Guglielmo G, Kandel ER, George O. PMID: 34742997; PMCID: PMC8816878.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders. J Neuroimmune Pharmacol. 2021 Oct 25. Simpson S, Mclellan R, Wellmeyer E, Matalon F, George O. PMID: 34694571; PMCID: PMC9074906.
      View in: PubMed   Mentions: 1     Fields:    
    11. How nicotine withdrawal symptoms fight each other: interpeduncular GABA neuron activity dynamically controls negative affect vs. coping behavior. Neuropsychopharmacology. 2022 02; 47(3):617-618. Avelar AJ, George O. PMID: 34593977; PMCID: PMC8783007.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3423-3433. Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. PMID: 34415376; PMCID: PMC8889911.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3). Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455; PMCID: PMC8213442.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats. Psychopharmacology (Berl). 2021 Aug; 238(8):2201-2211. Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. PMID: 33909102; PMCID: PMC8295227.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Front Syst Neurosci. 2021; 15:595507. Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. PMID: 33967705; PMCID: PMC8097000.
      View in: PubMed   Mentions: 1  
    16. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 2021 05 01; 188:108510. McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. PMID: 33647278; PMCID: PMC8099171.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. 2020 11 01; 178:108225. Smith LC, George O. PMID: 32758566; PMCID: PMC8344403.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    18. Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. Neuropsychopharmacology. 2020 10; 45(11):1909-1919. Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. PMID: 32544927; PMCID: PMC7608444.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    19. Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020 May/Jun; 7(3). Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. PMID: 32341122; PMCID: PMC7242819.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res. 2020 08 01; 1740:146850. Simpson S, Shankar K, Kimbrough A, George O. PMID: 32330519; PMCID: PMC7869920.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    21. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology (Berl). 2020 May; 237(5):1545-1555. Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. PMID: 32114633; PMCID: PMC7269712.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    22. Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. Pharmacol Biochem Behav. 2020 04; 191:172880. Lee CH, George O, Kimbrough A. PMID: 32105663; PMCID: PMC7269711.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2149-2159. Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. PMID: 31937658; PMCID: PMC6994986.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    24. Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Front Behav Neurosci. 2019; 13:292. de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. PMID: 31992976; PMCID: PMC6971096.
      View in: PubMed   Mentions: 8  
    25. Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2140-2148. Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. PMID: 31932450; PMCID: PMC6994987.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    26. Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Res. 2020 01 01; 1726:146502. de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP. PMID: 31605699; PMCID: PMC7195807.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    27. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020 03; 45(4):579-588. Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. PMID: 31593982; PMCID: PMC7021713.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    28. Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 10; 43(10):2079-2089. Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. PMID: 31403700; PMCID: PMC6779498.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 11; 29(11):1227-1234. Kallupi M, de Guglielmo G, Larrosa E, George O. PMID: 31462388; PMCID: PMC7899081.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    30. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240; PMCID: PMC6423296.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    31. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Sci Adv. 2018 10; 4(10):eaat4751. Kallupi M, Xue S, Zhou B, Janda KD, George O. PMID: 30345354; PMCID: PMC6192681.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 09 17; 8(1):13893. Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. PMID: 30224774; PMCID: PMC6141462.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    33. Negative Reinforcement Mechanisms in Addiction. 2018. Olivier George. . View Publication.
    34. Voluntary urination control by brainstem neurons that relax the urethral sphincter. Nat Neurosci. 2018 09; 21(9):1229-1238. Keller JA, Chen J, Simpson S, Wang EH, Lilascharoen V, George O, Lim BK, Stowers L. PMID: 30104734; PMCID: PMC6119086.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    35. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3). Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. PMID: 29971251; PMCID: PMC6027959.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    36. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Mol Psychiatry. 2018 12; 23(12):2266-2276. Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. PMID: 29880881; PMCID: PMC8276917.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav. 2018 04; 167:36-41. de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. PMID: 29505808; PMCID: PMC5866249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    38. An enzymatic advance in nicotine cessation therapy. Chem Commun (Camb). 2018 Feb 13; 54(14):1686-1689. Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. PMID: 29308799; PMCID: PMC6231713.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140. Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. PMID: 29354872; PMCID: PMC8162771.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 2018 06 15; 83(12):1024-1035. Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. PMID: 29357981; PMCID: PMC5960600.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    41. Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology. 2018 04; 43(5):1010-1020. Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. PMID: 29052613; PMCID: PMC5854806.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    42. CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895. Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. PMID: 28833238; PMCID: PMC5659873.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    43. Individual differences in the neuropsychopathology of addiction. Dialogues Clin Neurosci. 2017 09; 19(3):217-229. George O, Koob GF. PMID: 29302219; PMCID: PMC5741105.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    44. Compulsive-Like Sufentanil Vapor Self-Administration in Rats. Neuropsychopharmacology. 2018 03; 43(4):801-809. Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF. PMID: 28812595; PMCID: PMC5809787.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    45. Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Aug; 41(8):1502-1509. Kimbrough A, Kim S, Cole M, Brennan M, George O. PMID: 28679148; PMCID: PMC5531063.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    46. Nicotine Vapor Method to Induce Nicotine Dependence in Rodents. Curr Protoc Neurosci. 2017 Jul 05; 80:8.41.1-8.41.10. Kallupi M, George O. PMID: 28678400; PMCID: PMC5572764.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    47. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 09; 362(3):378-384. de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. PMID: 28645915; PMCID: PMC5539589.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    48. Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. Eur J Neurosci. 2017 Jul; 46(1):1673-1681. Grieder TE, George O, Yee M, Bergamini MA, Chwalek M, Maal-Bared G, Vargas-Perez H, van der Kooy D. PMID: 28498560; PMCID: PMC8162765.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    49. Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal. Neuropharmacology. 2017 Aug 01; 122:107-114. George O, Hope BT. PMID: 28435008; PMCID: PMC5512851.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017 04 26; 37(17):4593-4603. Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. PMID: 28363981; PMCID: PMC5413190.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    51. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018. de Guglielmo G, Kallupi M, Cole MD, George O. PMID: 28342089; PMCID: PMC5658208.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    52. Negative Affective States and Cognitive Impairments in Nicotine Dependence. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical). 2017. Olivier George and G.F. Koob. . View Publication.
    53. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155. Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. PMID: 27986929; PMCID: PMC5296793.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    54. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. PMID: 27917870; PMCID: PMC5520777.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    55. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53. de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. PMID: 27605618; PMCID: PMC5013191.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    56. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487. Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. PMID: 26733798; PMCID: PMC4689854.
      View in: PubMed   Mentions: 58  
    57. Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Jul 02; 6:7625. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 26133887.
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    58. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest. 2015 Aug 03; 125(8):3193-7. Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. PMID: 26121746; PMCID: PMC4563748.
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    59. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 25898242; PMCID: PMC4405813.
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    60. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53. Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. PMID: 25878294; PMCID: PMC4397613.
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    61. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015 Mar 11; 35(10):4296-305. Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. PMID: 25762676; PMCID: PMC4355200.
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    62. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8. Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. PMID: 25402857; PMCID: PMC4241147.
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    63. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63. Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. PMID: 25059540; PMCID: PMC4297709.
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    64. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener. 2014 Jul 01; 9:26. Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. PMID: 24980976; PMCID: PMC4107468.
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    65. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology (Berl). 2014 Oct; 231(19):3911-7. George O, Koob GF, Vendruscolo LF. PMID: 24923982; PMCID: PMC8278497.
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    66. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behav Brain Res. 2014 Sep 01; 271:171-6. Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. PMID: 24914463; PMCID: PMC4216724.
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    67. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One. 2014; 9(5):e97216. Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. PMID: 24816773; PMCID: PMC4016270.
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    68. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci. 2013 Dec 04; 33(49):19384-92. Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. PMID: 24305833; PMCID: PMC3850049.
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    69. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology (Berl). 2014 Mar; 231(5):929-37. Buck CL, Vendruscolo LF, Koob GF, George O. PMID: 24221826; PMCID: PMC3945412.
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    70. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addict Biol. 2015 Jan; 20(1):56-68. Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. PMID: 23869743; PMCID: PMC3859819.
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    71. Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan; 76 Pt B:370-82. Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. PMID: 23747571; PMCID: PMC3830720.
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    72. Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. Front Psychiatry. 2013; 4:41. Cohen A, George O. PMID: 23761766; PMCID: PMC3671664.
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    73. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep; 19(5):755-7. Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. PMID: 23639035; PMCID: PMC3872251.
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    74. Control of craving by the prefrontal cortex. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4165-6. George O, Koob GF. PMID: 23483010; PMCID: PMC3600441.
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    75. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74. Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. PMID: 23278919; PMCID: PMC3620729.
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    76. Nicotine vapor inhalation escalates nicotine self-administration. Addict Biol. 2014 Jul; 19(4):587-92. Gilpin NW, Whitaker AM, Baynes B, Abdel AY, Weil MT, George O. PMID: 23240929; PMCID: PMC4516274.
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    77. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. PMID: 23071333; PMCID: PMC3497825.
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    78. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology. 2012 Aug; 37(9):2153-60. Cohen A, Koob GF, George O. PMID: 22549121; PMCID: PMC3398720.
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    79. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology (Berl). 2012 Sep; 223(2):159-68. Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. PMID: 22526534; PMCID: PMC3464481.
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    80. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology (Berl). 2012 Sep; 223(1):17-25. Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. PMID: 22418732; PMCID: PMC3464482.
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    81. Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3101-6. Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. PMID: 22308372; PMCID: PMC3286981.
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    82. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. PMID: 22205547; PMCID: PMC3306889.
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    83. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiol Behav. 2012 Apr 12; 106(1):58-64. George O, Le Moal M, Koob GF. PMID: 22108506; PMCID: PMC3288230.
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    84. Craving, context and the cortex. Nat Neurosci. 2011 Apr; 14(4):409-10. George O, Koob GF. PMID: 21445066; PMCID: PMC3829767.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    85. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology (Berl). 2011 Feb; 213(4):715-22. George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. PMID: 20924754; PMCID: PMC3033995.
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    86. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2010 Nov; 35(2):232-47. George O, Koob GF. PMID: 20493211; PMCID: PMC2955797.
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    87. Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats. Biol Psychiatry. 2010 Nov 15; 68(10):956-63. George O, Vallée M, Vitiello S, Le Moal M, Piazza PV, Mayo W. PMID: 20471631; PMCID: PMC2936666.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    88. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacol Biochem Behav. 2010 Jul; 96(1):104-7. George O, Grieder TE, Cole M, Koob GF. PMID: 20420848; PMCID: PMC2878929.
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    89. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci. 2009 Apr 15; 29(15):4846-57. Orio L, Edwards S, George O, Parsons LH, Koob GF. PMID: 19369553; PMCID: PMC2688678.
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    90. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82. George O, Mandyam CD, Wee S, Koob GF. PMID: 18033234; PMCID: PMC2760333.
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    91. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17198-203. George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. PMID: 17921249; PMCID: PMC2040467.
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    92. Motherhood-induced memory improvement persists across lifespan in rats but is abolished by a gestational stress. Eur J Neurosci. 2006 Jun; 23(12):3368-74. Lemaire V, Billard JM, Dutar P, George O, Piazza PV, Epelbaum J, Le Moal M, Mayo W. PMID: 16820026.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    93. Chronic exposure of rats to noise: relationship between long-term memory deficits and slow wave sleep disturbances. Behav Brain Res. 2006 Aug 10; 171(2):303-12. Rabat A, Bouyer JJ, George O, Le Moal M, Mayo W. PMID: 16716416.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    94. Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. Psychopharmacology (Berl). 2006 Jun; 186(3):402-13. George O, Vallée M, Le Moal M, Mayo W. PMID: 16416333.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    95. Smad-dependent alterations of PPT cholinergic neurons as a pathophysiological mechanism of age-related sleep-dependent memory impairments. Neurobiol Aging. 2006 Dec; 27(12):1848-58. George O, Parducz A, Dupret D, Kharouby M, Le Moal M, Piazza PV, Mayo W. PMID: 16316709.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    96. New insights into the role of neuroactive steroids in cognitive aging. Exp Gerontol. 2004 Nov-Dec; 39(11-12):1695-704. Vallée M, George O, Vitiello S, Le Moal M, Mayo W. PMID: 15582285.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    97. Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus. J Neurosci Res. 2004 Jun 01; 76(5):742-7. Darbra S, George O, Bouyer JJ, Piazza PV, Le Moal M, Mayo W. PMID: 15139033.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    98. Individual differences in cognitive aging: implication of pregnenolone sulfate. Prog Neurobiol. 2003 Sep; 71(1):43-8. Mayo W, George O, Darbra S, Bouyer JJ, Vallée M, Darnaudéry M, Pallarès M, Lemaire-Mayo V, Le Moal M, Piazza PV, Abrous N. PMID: 14611866.
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