Olivier George

Title(s)Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0002-3700-5003 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Bordeaux, Bordeaux, France PhD2004Neuroscience and Neuropharmacology
    University of Bordeaux, Bordeaux, FranceBS/MS2001Neuroscience and Neuropharmacology
    Collapse Awards and Honors
    American College of Neuropsychopharmacology2020Member
    College on Problems of Drug and Dependence2019Member
    UC San Diego Altman Clinical and Translational Research Institute2019General Member
    3rd International meeting on Steroids and Nervous System2003Young Researcher Travel Award
    French Ministry of Education and Research 2001Doctoral Training Merit Award (MENRT)
    University of Bordeaux2000Predoctoral Merit Award

    Collapse Overview 
    Collapse Overview
    Olivier George, Ph.D. is a Professor at the University of California San Diego, School of Medicine in the department of Psychiatry. He serves as the Co-Director of the Animal Core of the Scripps Research Alcohol Research Center, and Director of the Cocaine and Oxycodone Biobanks.
    Dr. George received his Ph.D. from the University of Bordeaux (France) where he worked with Drs. Le Moal, Piazza and Mayo on the role of cholinergic neurons in age-related sleep and memory impairments. He went on to conduct postdoctoral work on animal models of addiction at The Scripps Research Institute in La Jolla with Dr. Koob, before joining the faculty in 2013. He has studied alcohol, nicotine and drug addiction for more than 15 years, starting with his postdoctoral studies that were the first to identify the role of corticotropin releasing factor in escalation of nicotine self-administration and demonstrating that escalation of cocaine, methamphetamine and alcohol intake produces a dysfunction of the prefrontal cortex leading to cognitive impairment.
    Dr. George has made several breakthrough discoveries including identifying the neuronal ensembles of alcohol and nicotine addiction and discovering a novel neuronal population that drives negative emotional states in nicotine addiction. Dr. George has also pioneered the development of novel animal models of nicotine, opioid and alcohol addiction using electronic cigarette vapor self-administration. His recent work focuses on unveiling the genetic basis of addiction and identifying brain-wide functional architecture remodeling in animal models of drug addiction using single-cell whole brain imaging. His studies span multiple levels of approaches from molecular to integrated systems using state-of-the-art animal models of addiction with strong translational relevance. Using these approaches, he has contributed to the development of several Investigational New Drugs and hold several patents.
    Dr. GEorge has given over 120 talks to audiences of all levels, from high school, undergraduate and graduate students, to the general public and scientific colleagues in the field. Dr. George has published more than 70 papers in peer-reviewed journals. His work is supported by the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol and Alcoholism (NIAAA), the Tobacco-Related Disease Research Program (TRDRP).
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    Collapse Research 
    Collapse Research Activities and Funding
    Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsiveOxycodone Intake in Outbred Rats
    NIH U01DA044451Apr 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Neurobehavioral effects of nicotine e-cig self-administration in rats
    TRDRP 27IR-0047Apr 1, 2018 - Mar 31, 2021
    Role: PI
    Neuronal ensembles of compulsive alcohol drinking
    NIH R01AA026081Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake inRats
    NIH U01DA043799Apr 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Effect of Exposure to Nicotine Vapor on the Vulnerability to Nicotine Dependence
    NIH R21DA036691Sep 15, 2014 - Aug 31, 2017
    Role: Principal Investigator
    Alcohol Vapor Self-Administration in Rats
    NIH R01AA022977May 1, 2014 - Jun 30, 2024
    Role: Principal Investigator
    The Role of Brain Stress Systems in the Prefrontal Cortex in Compulsive Drinking
    NIH R01AA020608Aug 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Neuropharmacology of Ethanol Reinforcement
    NIH R01AA008459Apr 1, 1990 - Apr 30, 2015
    Role: Principal Investigator
    Neuronal Substrates of Cocaine Reward
    NIH R01DA004398Apr 25, 1987 - Mar 31, 2016
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology (Berl). 2021 Aug 20. Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. PMID: 34415376.
      View in: PubMed   Mentions:    Fields:    
    2. The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3). Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Front Syst Neurosci. 2021; 15:595507. Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. PMID: 33967705.
      View in: PubMed   Mentions:
    4. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. 2020 11 01; 178:108225. Smith LC, George O. PMID: 32758566.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020 May/Jun; 7(3). Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. PMID: 32341122.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    6. Role of corticotropin-releasing factor in alcohol and nicotine addiction. Brain Res. 2020 08 01; 1740:146850. Simpson S, Shankar K, Kimbrough A, George O. PMID: 32330519.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology (Berl). 2020 May; 237(5):1545-1555. Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. PMID: 32114633.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. Pharmacol Biochem Behav. 2020 04; 191:172880. Lee CH, George O, Kimbrough A. PMID: 32105663.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2149-2159. Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. PMID: 31937658.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    10. Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Front Behav Neurosci. 2019; 13:292. de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. PMID: 31992976.
      View in: PubMed   Mentions:
    11. Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2140-2148. Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. PMID: 31932450.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    12. Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Res. 2020 01 01; 1726:146502. de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP. PMID: 31605699.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    13. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020 03; 45(4):579-588. Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. PMID: 31593982.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    14. Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 10; 43(10):2079-2089. Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. PMID: 31403700.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 11; 29(11):1227-1234. Kallupi M, de Guglielmo G, Larrosa E, George O. PMID: 31462388.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    17. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Sci Adv. 2018 10; 4(10):eaat4751. Kallupi M, Xue S, Zhou B, Janda KD, George O. PMID: 30345354.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 09 17; 8(1):13893. Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. PMID: 30224774.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    19. Negative Reinforcement Mechanisms in Addiction. 2018. Olivier George. . View Publication.
    20. Voluntary urination control by brainstem neurons that relax the urethral sphincter. Nat Neurosci. 2018 09; 21(9):1229-1238. Keller JA, Chen J, Simpson S, Wang EH, Lilascharoen V, George O, Lim BK, Stowers L. PMID: 30104734.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    21. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3). Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. PMID: 29971251.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    22. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Mol Psychiatry. 2018 12; 23(12):2266-2276. Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. PMID: 29880881.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav. 2018 04; 167:36-41. de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. PMID: 29505808.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    24. An enzymatic advance in nicotine cessation therapy. Chem Commun (Camb). 2018 Feb 13; 54(14):1686-1689. Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. PMID: 29308799.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140. Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. PMID: 29354872.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    26. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biol Psychiatry. 2018 06 15; 83(12):1024-1035. Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. PMID: 29357981.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    27. Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology. 2018 04; 43(5):1010-1020. Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. PMID: 29052613.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    28. CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895. Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. PMID: 28833238.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    29. Individual differences in the neuropsychopathology of addiction. Dialogues Clin Neurosci. 2017 09; 19(3):217-229. George O, Koob GF. PMID: 29302219.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    30. Compulsive-Like Sufentanil Vapor Self-Administration in Rats. Neuropsychopharmacology. 2018 03; 43(4):801-809. Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF. PMID: 28812595.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Aug; 41(8):1502-1509. Kimbrough A, Kim S, Cole M, Brennan M, George O. PMID: 28679148.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    32. Nicotine Vapor Method to Induce Nicotine Dependence in Rodents. Curr Protoc Neurosci. 2017 Jul 05; 80:8.41.1-8.41.10. Kallupi M, George O. PMID: 28678400.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    33. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 09; 362(3):378-384. de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. PMID: 28645915.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    34. Deletion of a5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. Eur J Neurosci. 2017 Jul; 46(1):1673-1681. Grieder TE, George O, Yee M, Bergamini MA, Chwalek M, Maal-Bared G, Vargas-Perez H, van der Kooy D. PMID: 28498560.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    35. Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal. Neuropharmacology. 2017 Aug 01; 122:107-114. George O, Hope BT. PMID: 28435008.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017 04 26; 37(17):4593-4603. Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. PMID: 28363981.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    37. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018. de Guglielmo G, Kallupi M, Cole MD, George O. PMID: 28342089.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    38. Negative Affective States and Cognitive Impairments in Nicotine Dependence. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical). 2017. Olivier George and G.F. Koob. . View Publication.
    39. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155. Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. PMID: 27986929.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    40. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. PMID: 27917870.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    41. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53. de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. PMID: 27605618.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    42. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487. Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. PMID: 26733798.
      View in: PubMed   Mentions:
    43. Corrigendum: Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Jul 02; 6:7625. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 26133887.
      View in: PubMed   Mentions: 2     Fields:    
    44. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest. 2015 Aug 03; 125(8):3193-7. Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. PMID: 26121746.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    45. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nat Commun. 2015 Apr 21; 6:6770. Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. PMID: 25898242.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    46. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53. Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. PMID: 25878294.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    47. ? Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015 Mar 11; 35(10):4296-305. Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. PMID: 25762676.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    48. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nat Neurosci. 2014 Dec; 17(12):1751-8. Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. PMID: 25402857.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    49. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology (Berl). 2015 Jan; 232(2):453-63. Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. PMID: 25059540.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    50. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Mol Neurodegener. 2014 Jul 01; 9:26. Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. PMID: 24980976.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    51. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology (Berl). 2014 Oct; 231(19):3911-7. George O, Koob GF, Vendruscolo LF. PMID: 24923982.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    52. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behav Brain Res. 2014 Sep 01; 271:171-6. Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. PMID: 24914463.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    53. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One. 2014; 9(5):e97216. Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. PMID: 24816773.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Long-term antagonism of ? opioid receptors prevents escalation of and increased motivation for heroin intake. J Neurosci. 2013 Dec 04; 33(49):19384-92. Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. PMID: 24305833.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    55. Dopamine D1 and µ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology (Berl). 2014 Mar; 231(5):929-37. Buck CL, Vendruscolo LF, Koob GF, George O. PMID: 24221826.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    56. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addict Biol. 2015 Jan; 20(1):56-68. Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. PMID: 23869743.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    57. Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan; 76 Pt B:370-82. Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. PMID: 23747571.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimals
    58. Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. Front Psychiatry. 2013; 4:41. Cohen A, George O. PMID: 23761766.
      View in: PubMed   Mentions:
    59. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep; 19(5):755-7. Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. PMID: 23639035.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    60. Control of craving by the prefrontal cortex. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4165-6. George O, Koob GF. PMID: 23483010.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    61. Hippocampal neurogenesis protects against cocaine-primed relapse. Addict Biol. 2014 Jul; 19(4):562-74. Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. PMID: 23278919.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Nicotine vapor inhalation escalates nicotine self-administration. Addict Biol. 2014 Jul; 19(4):587-92. Gilpin NW, Whitaker AM, Baynes B, Abdel AY, Weil MT, George O. PMID: 23240929.
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    63. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18156-61. George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. PMID: 23071333.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    64. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology. 2012 Aug; 37(9):2153-60. Cohen A, Koob GF, George O. PMID: 22549121.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    65. Effects of the specific a4ß2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology (Berl). 2012 Sep; 223(2):159-68. Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. PMID: 22526534.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    66. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology (Berl). 2012 Sep; 223(1):17-25. Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. PMID: 22418732.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    67. Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3101-6. Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. PMID: 22308372.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    68. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr; 37(5):1275-87. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. PMID: 22205547.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    69. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiol Behav. 2012 Apr 12; 106(1):58-64. George O, Le Moal M, Koob GF. PMID: 22108506.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    70. Craving, context and the cortex. Nat Neurosci. 2011 Apr; 14(4):409-10. George O, Koob GF. PMID: 21445066.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    71. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology (Berl). 2011 Feb; 213(4):715-22. George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. PMID: 20924754.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    72. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev. 2010 Nov; 35(2):232-47. George O, Koob GF. PMID: 20493211.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimals
    73. Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats. Biol Psychiatry. 2010 Nov 15; 68(10):956-63. George O, Vallée M, Vitiello S, Le Moal M, Piazza PV, Mayo W. PMID: 20471631.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    74. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacol Biochem Behav. 2010 Jul; 96(1):104-7. George O, Grieder TE, Cole M, Koob GF. PMID: 20420848.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    75. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci. 2009 Apr 15; 29(15):4846-57. Orio L, Edwards S, George O, Parsons LH, Koob GF. PMID: 19369553.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    76. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology. 2008 Sep; 33(10):2474-82. George O, Mandyam CD, Wee S, Koob GF. PMID: 18033234.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    77. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17198-203. George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. PMID: 17921249.
      View in: PubMed   Mentions: 134     Fields:    Translation:Animals
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