Tracy Handel

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.California Institute of Technology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    It's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12
    NIH R01AI161880Apr 15, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, G?? and arrestins
    NIH R01CA254402Jun 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Signaling circuits that drive cell movement and ligand scavenging by chemokine receptor CCR2
    NIH R01GM136202May 1, 2020 - Jan 31, 2024
    Role: Principal Investigator
    Insights into Activation Mechanisms of G Protein-Coupled and Atypical ?-Arrestin-Coupled Chemokine Receptors
    NIH R01GM133157Apr 1, 2019 - Mar 31, 2023
    Role: Co-Principal Investigator
    Chemokine interaction with CXCR4 and ACKR3: structure and activation mechanisms
    NIH R01GM117424Sep 15, 2016 - May 31, 2020
    Role: Principal Investigator
    2016 Chemotactic Cytokines Gordon Research Conference & Gordon Research Seminar
    NIH R13AI124469Mar 15, 2016 - Feb 28, 2017
    Role: Principal Investigator
    Dissecting the interactions of gp120 with chemokine receptor CXCR4
    NIH R21AI121918Jan 15, 2016 - Dec 31, 2018
    Role: Principal Investigator
    Structure Determination of the Chemokine Receptor CCR2 with Novel Inhibitors
    NIH R21AI122211Jan 1, 2016 - Dec 31, 2018
    Role: Principal Investigator
    The structural plasticity of chemokine and gp120 recognition by CCR5
    NIH R01AI118985May 11, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Synthetic Fabs for Crystallization of Chemokine:Receptor Complexes
    NIH R21AI101687Jul 24, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Structure, Dynamics and Activation Mechanisms of Chemokine Receptors
    NIH U01GM094612Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    Sensitive Deuterium Exchange MS for Membrane Proteins
    NIH R01GM093325Sep 30, 2010 - Aug 31, 2013
    Role: Principal Investigator
    Engineering Chemokine Receptor Signaling Complexes In Vitro
    NIH R01GM081763Jun 1, 2009 - May 31, 2013
    Role: Principal Investigator
    Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
    NIH R21AI076961Jun 15, 2008 - May 31, 2011
    Role: Principal Investigator
    Structure-Function Studies & Molecular Interactions of Chemokines
    NIH R01AI037113Dec 1, 1994 - Nov 30, 2015
    Role: Principal Investigator
    Graduate Training in Cellular and Molecular Pharmacology
    NIH T32GM007752Jul 1, 1979 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5. bioRxiv. 2024 Feb 12. Dawson JRD, Wadman GM, Zhang P, Tebben A, Carter PH, Gu S, Shroka T, Borrega-Roman L, Salanga CL, Handel TM, Kufareva I. PMID: 38014122; PMCID: PMC10680698.
      View in: PubMed   Mentions:
    2. Ligand-Dependent Mechanisms of C-C Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics. bioRxiv. 2023 Nov 03. Gu S, Maurya S, Lona A, Borrega-Roman L, Salanga C, Gonzalez DJ, Kufareva I, Handel TM. PMID: 37961097; PMCID: PMC10635066.
      View in: PubMed   Mentions:
    3. Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes. bioRxiv. 2023 Nov 02. Schafer CT, Pauszek Iii RF, Gustavsson M, Handel TM, Millar DP. PMID: 37961571; PMCID: PMC10635023.
      View in: PubMed   Mentions:
    4. On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies. STAR Protoc. 2023 Sep 15; 4(3):102460. Gu S, Huang M, Handel TM. PMID: 37516969; PMCID: PMC10407235.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. Mol Pharmacol. 2023 10; 104(4):174-186. Schafer CT, Chen Q, Tesmer JJG, Handel TM. PMID: 37474305.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding. bioRxiv. 2023 Jul 19. Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. PMID: 37502840; PMCID: PMC10370059.
      View in: PubMed   Mentions:
    7. Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv. 2023 Mar 10. Schafer CT, Chen Q, Tesmer JJG, Handel TM. PMID: 36865154; PMCID: PMC9980177.
      View in: PubMed   Mentions:
    8. The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms. Sci Signal. 2023 01 31; 16(770):eabo4314. Shroka TM, Kufareva I, Salanga CL, Handel TM. PMID: 36719944; PMCID: PMC10091583.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    9. Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Rep. 2023 01 31; 42(1):111930. Gray AL, Karlsson R, Roberts ARE, Ridley AJL, Pun N, Khan B, Lawless C, Luís R, Szpakowska M, Chevigné A, Hughes CE, Medina-Ruiz L, Birchenough HL, Mulholland IZ, Salanga CL, Yates EA, Turnbull JE, Handel TM, Graham GJ, Jowitt TA, Schiessl I, Richter RP, Miller RL, Dyer DP. PMID: 36640356.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    10. Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv. 2022 07 15; 8(28):eabn8063. Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM. PMID: 35857509; PMCID: PMC9278869.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    11. Anticancer opportunities at every stage of chemokine function. Trends Pharmacol Sci. 2021 11; 42(11):912-928. Ortiz Zacarías NV, Bemelmans MP, Handel TM, de Visser KE, Heitman LH. PMID: 34521537.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. J Med Chem. 2021 03 11; 64(5):2608-2621. Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. PMID: 33600174; PMCID: PMC7958898.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions. J Histochem Cytochem. 2021 02; 69(2):87-91. Handel TM, Dyer DP. PMID: 33285085; PMCID: PMC7838337.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    14. Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. J Biol Chem. 2021 Jan-Jun; 296:100139. Ward RJ, Pediani JD, Marsango S, Jolly R, Stoneman MR, Biener G, Handel TM, Raicu V, Milligan G. PMID: 33268380; PMCID: PMC7949023.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis. Sci Signal. 2020 07 14; 13(640). Stephens BS, Ngo T, Kufareva I, Handel TM. PMID: 32665413; PMCID: PMC7437921.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors. J Leukoc Biol. 2020 06; 107(6):1123-1135. Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A. PMID: 32374043; PMCID: PMC7540625.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity. PLoS Biol. 2020 04; 18(4):e3000656. Ngo T, Stephens BS, Gustavsson M, Holden LG, Abagyan R, Handel TM, Kufareva I. PMID: 32271748; PMCID: PMC7173943.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    18. CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood. J Immunol. 2019 12 15; 203(12):3157-3165. Zhao BN, Campbell JJ, Salanga CL, Ertl LS, Wang Y, Yau S, Dang T, Zeng Y, McMahon JP, Krasinski A, Zhang P, Kufareva I, Handel TM, Charo IF, Singh R, Schall TJ. PMID: 31676674; PMCID: PMC7028331.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding. Sci Signal. 2019 09 10; 12(598). Gustavsson M, Dyer DP, Zhao C, Handel TM. PMID: 31506383; PMCID: PMC7063449.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    20. Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans. Trends Immunol. 2019 06; 40(6):472-481. Graham GJ, Handel TM, Proudfoot AEI. PMID: 31006548.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    21. Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3. Methods Cell Biol. 2019; 149:259-288. Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF. PMID: 30616824; PMCID: PMC6941889.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry. Biochem Pharmacol. 2018 12; 158:402-412. Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D. PMID: 30342024.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    23. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. PMID: 30232011; PMCID: PMC6226018.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. Editorial: Chemokines - beyond chemotaxis. Cytokine. 2018 09; 109:1. Proudfoot AE, Handel TM, Graham G. PMID: 29861383.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Intracellular Receptor Modulation: Novel Approach to Target GPCRs. Trends Pharmacol Sci. 2018 06; 39(6):547-559. Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH. PMID: 29653834; PMCID: PMC7048003.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    26. Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System. Pharmaceuticals (Basel). 2017 Aug 09; 10(3). Proudfoot AEI, Johnson Z, Bonvin P, Handel TM. PMID: 28792472; PMCID: PMC5620614.
      View in: PubMed   Mentions: 62  
    27. Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements. J Am Chem Soc. 2017 07 19; 139(28):9534-9543. Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ. PMID: 28651046; PMCID: PMC5588662.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    28. Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 2017 06 20; 46(6):1005-1017.e5. Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM. PMID: 28636951; PMCID: PMC5572563.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    29. What Do Structures Tell Us About Chemokine Receptor Function and Antagonism? Annu Rev Biophys. 2017 05 22; 46:175-198. Kufareva I, Gustavsson M, Zheng Y, Stephens BS, Handel TM. PMID: 28532213; PMCID: PMC5764094.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    30. Structural basis of ligand interaction with atypical chemokine receptor 3. Nat Commun. 2017 01 18; 8:14135. Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel TM. PMID: 28098154; PMCID: PMC5253664.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    31. Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization. Open Biol. 2017 01; 7(1). Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel TM, Richter RP. PMID: 28123055; PMCID: PMC5303277.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 12 15; 540(7633):458-461. Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM. PMID: 27926736; PMCID: PMC5159191.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    33. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9928-33. Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel TM, Doranz BJ. PMID: 27543332; PMCID: PMC5024644.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    34. The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. J Biol Chem. 2016 Jun 10; 291(24):12627-12640. Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel TM. PMID: 27044744; PMCID: PMC4933465.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    35. Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer. Biochemistry. 2016 Mar 01; 55(8):1214-25. Fox JC, Tyler RC, Peterson FC, Dyer DP, Zhang F, Linhardt RJ, Handel TM, Volkman BF. PMID: 26836755; PMCID: PMC4775286.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes. Methods Enzymol. 2016; 570:389-420. Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel TM. PMID: 26921956; PMCID: PMC4782801.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    37. Preface. Methods Enzymol. 2016; 570:xxi-xxii. Handel TM. PMID: 26921963.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. Methods Enzymol. 2016; 570:233-60. Gustavsson M, Zheng Y, Handel TM. PMID: 26921949; PMCID: PMC4770566.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology. 2016 Mar; 26(3):312-26. Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel TM. PMID: 26582609; PMCID: PMC4736540.
      View in: PubMed   Mentions: 65     Fields:    Translation:Cells
    40. Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions. Methods Enzymol. 2016; 570:335-55. Yin X, Johns SC, El Ghazal R, Salanga CL, Handel TM, Fuster MM. PMID: 26921954.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    41. Cytokines and growth factors cross-link heparan sulfate. Open Biol. 2015 Aug; 5(8). Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP. PMID: 26269427; PMCID: PMC4554917.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    42. Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines. J Biol Chem. 2015 Sep 11; 290(37):22385-97. Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel TM. PMID: 26216880; PMCID: PMC4566214.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    43. The Structure of a CXCR4:Chemokine Complex. Front Immunol. 2015; 6:282. Handel TM. PMID: 26097480; PMCID: PMC4457019.
      View in: PubMed   Mentions: 6     Fields:    
    44. Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands. Structure. 2015 Jun 02; 23(6):1066-77. Deshauer C, Morgan AM, Ryan EO, Handel TM, Prestegard JH, Wang X. PMID: 25982530; PMCID: PMC4456249.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    45. Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunol Cell Biol. 2015 Apr; 93(4):372-83. Kufareva I, Salanga CL, Handel TM. PMID: 25708536; PMCID: PMC4406842.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    46. Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 06; 347(6226):1117-22. Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM. PMID: 25612609; PMCID: PMC4362693.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    47. Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods Mol Biol. 2015; 1335:295-311. Kufareva I, Handel TM, Abagyan R. PMID: 26260608; PMCID: PMC4551442.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    48. Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5363-72. Kufareva I, Stephens BS, Holden LG, Qin L, Zhao C, Kawamura T, Abagyan R, Handel TM. PMID: 25468967; PMCID: PMC4273337.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    49. Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display. J Biol Chem. 2014 Nov 14; 289(46):31846-31855. Bonvin P, Dunn SM, Rousseau F, Dyer DP, Shaw J, Power CA, Handel TM, Proudfoot AEI. PMID: 25266725; PMCID: PMC4231662.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    50. Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine. J Biol Chem. 2014 May 23; 289(21):14896-912. Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel TM. PMID: 24727473; PMCID: PMC4031540.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    51. Chemokine cooperativity is caused by competitive glycosaminoglycan binding. J Immunol. 2014 Apr 15; 192(8):3908-3914. Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ. PMID: 24639348; PMCID: PMC4198333.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    52. TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8. J Immunol. 2014 Mar 01; 192(5):2177-85. Dyer DP, Thomson JM, Hermant A, Jowitt TA, Handel TM, Proudfoot AE, Day AJ, Milner CM. PMID: 24501198; PMCID: PMC3988464.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    53. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014 Mar 01; 192(5):2133-42. Yin X, Johns SC, Kim D, Mikulski Z, Salanga CL, Handel TM, Macal M, Zúñiga EI, Fuster MM. PMID: 24493818; PMCID: PMC3960083.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. PMID: 24489642; PMCID: PMC3904831.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    55. The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-32210. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. PMID: 24056371; PMCID: PMC3820859.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    56. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol. 2013 Sep 20; 8(9):1955-63. Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF. PMID: 23802178; PMCID: PMC3783652.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    57. Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites. J Immunol. 2013 Aug 01; 191(3):1110-7. Kara EE, Comerford I, Bastow CR, Fenix KA, Litchfield W, Handel TM, McColl SR. PMID: 23797668; PMCID: PMC3721028.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    58. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. PMID: 23667177; PMCID: PMC3679389.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 06; 13(6):412-24. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. PMID: 23640210; PMCID: PMC4068741.
      View in: PubMed   Mentions: 285     Fields:    Translation:HumansAnimalsCells
    60. A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods Mol Biol. 2013; 1013:93-127. Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. PMID: 23625495; PMCID: PMC4091634.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    61. Chemokine oligomerization in cell signaling and migration. Prog Mol Biol Transl Sci. 2013; 117:531-78. Wang X, Sharp JS, Handel TM, Prestegard JH. PMID: 23663982; PMCID: PMC3937849.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    62. Chemokine receptor oligomerization and allostery. Prog Mol Biol Transl Sci. 2013; 115:375-420. Stephens B, Handel TM. PMID: 23415099; PMCID: PMC4072031.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    63. Opportunities for functional selectivity in GPCR antibodies. Biochem Pharmacol. 2013 Jan 15; 85(2):147-52. Webb DR, Handel TM, Kretz-Rommel A, Stevens RC. PMID: 22975405; PMCID: PMC3729224.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    64. Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. PMID: 22791291; PMCID: PMC3429312.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    65. Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Mol Med. 2012 Feb 10; 18:19-28. Fecteau JF, Bharati IS, O'Hayre M, Handel TM, Kipps TJ, Messmer D. PMID: 21979753; PMCID: PMC3269641.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    66. Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 2012 Jul; 26(7):1689-92. O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. PMID: 22237780; PMCID: PMC3395972.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    67. Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem. 2012 Feb 17; 287(8):5542-53. Zhang S, Condac E, Qiu H, Jiang J, Gutierrez-Sanchez G, Bergmann C, Handel T, Wang L. PMID: 22194593; PMCID: PMC3285330.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    68. Oligomeric structure of the chemokine CCL5/RANTES from NMR, MS, and SAXS data. Structure. 2011 Aug 10; 19(8):1138-48. Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH. PMID: 21827949; PMCID: PMC3159919.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    69. Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. J Immunol. 2011 Aug 01; 187(3):1403-10. Kulig P, Kantyka T, Zabel BA, Banas M, Chyra A, Stefanska A, Tu H, Allen SJ, Handel TM, Kozik A, Potempa J, Butcher EC, Cichy J. PMID: 21715684; PMCID: PMC3140563.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    70. A rapid and efficient way to obtain modified chemokines for functional and biophysical studies. Cytokine. 2011 Aug; 55(2):168-73. Allen SJ, Hamel DJ, Handel TM. PMID: 21632261; PMCID: PMC3126891.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    71. Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. J Med Chem. 2011 Mar 24; 54(6):1667-81. Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC. PMID: 21341682; PMCID: PMC3229226.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    72. Specificity and cooperativity at β-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions. Proteins. 2011 Apr; 79(4):1267-76. Hanes MS, Reynolds KA, McNamara C, Ghosh P, Bonomo RA, Kirsch JF, Handel TM. PMID: 21294157; PMCID: PMC3417816.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    73. Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function. Exp Cell Res. 2011 Mar 10; 317(5):590-601. Salanga CL, Handel TM. PMID: 21223963; PMCID: PMC3089961.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    74. A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis. Mol Cancer. 2010 Dec 20; 9:316. Yin X, Truty J, Lawrence R, Johns SC, Srinivasan RS, Handel TM, Fuster MM. PMID: 21172016; PMCID: PMC3019167.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    75. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011 Jan 20; 117(3):882-9. Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel TM, Kipps TJ. PMID: 21079155; PMCID: PMC3035080.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    76. Emerging concepts and approaches for chemokine-receptor drug discovery. Expert Opin Drug Discov. 2010 Nov; 5(11):1109-22. O'Hayre M, Salanga CL, Handel TM, Hamel DJ. PMID: 21132095; PMCID: PMC2995586.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    77. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19; 330(6007):1066-71. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. PMID: 20929726; PMCID: PMC3074590.
      View in: PubMed   Mentions: 792     Fields:    Translation:HumansAnimalsCells
    78. Protein-protein binding affinities by pulse proteolysis: application to TEM-1/BLIP protein complexes. Protein Sci. 2010 Oct; 19(10):1996-2000. Hanes MS, Ratcliff K, Marqusee S, Handel TM. PMID: 20669180; PMCID: PMC2998734.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    79. Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS One. 2010 Jul 22; 5(7):e11716. O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM. PMID: 20661426; PMCID: PMC2908618.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    80. Duffy antigen inhibitors: useful therapeutics for malaria? Trends Parasitol. 2010 Jul; 26(7):329-33. Handel TM, Horuk R. PMID: 20382562.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    81. Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans. J Biol Chem. 2010 Jun 04; 285(23):17713-24. Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T. PMID: 20363748; PMCID: PMC2878535.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    82. Structure of the minimal interface between ApoE and LRP. J Mol Biol. 2010 Apr 30; 398(2):306-19. Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. PMID: 20303980; PMCID: PMC2880916.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    83. NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem. 2010 May 07; 285(19):14424-37. Jansma AL, Kirkpatrick JP, Hsu AR, Handel TM, Nietlispach D. PMID: 20200157; PMCID: PMC2863231.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    84. Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry. 2009 Oct 06; 48(39):9185-93. Hanes MS, Jude KM, Berger JM, Bonomo RA, Handel TM. PMID: 19731932; PMCID: PMC2769493.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    85. Modulation of chemokine receptor activity through dimerization and crosstalk. Cell Mol Life Sci. 2009 Apr; 66(8):1370-86. Salanga CL, O'Hayre M, Handel T. PMID: 19099182; PMCID: PMC2738873.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    86. Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1. Protein Expr Purif. 2009 Jul; 66(1):73-81. Allen SJ, Ribeiro S, Horuk R, Handel TM. PMID: 19275940; PMCID: PMC2706832.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    87. Phosphoproteomic analysis of chemokine signaling networks. Methods Enzymol. 2009; 460:331-46. O'Hayre M, Salanga CL, Dorrestein PC, Handel TM. PMID: 19446733.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    88. Chapter 2. Homo- and hetero-oligomerization of chemokines. Methods Enzymol. 2009; 461:31-50. Jansma A, Handel TM, Hamel DJ. PMID: 19480913.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    89. Chapter 4. Interactions of chemokines with glycosaminoglycans. Methods Enzymol. 2009; 461:71-102. Hamel DJ, Sielaff I, Proudfoot AE, Handel TM. PMID: 19480915.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    90. Methods to probe the physical characteristics, dynamics, modifications, and interactions of chemokines and chemokine receptors. Preface. Methods Enzymol. 2009; 461:xv. Hamel DJ, Handel TM. PMID: 19480911.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    91. Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angew Chem Int Ed Engl. 2009; 48(4):767-70. Winter JM, Jansma AL, Handel TM, Moore BS. PMID: 19072974; PMCID: PMC3517086.
      View in: PubMed   Mentions: 25     Fields:    
    92. Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem. 2009 Jan 09; 284(2):751-8. Du XY, Zabel BA, Myles T, Allen SJ, Handel TM, Lee PP, Butcher EC, Leung LL. PMID: 19010784; PMCID: PMC2613638.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    93. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med. 2008 Sep 29; 205(10):2207-20. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC. PMID: 18794339; PMCID: PMC2556791.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    94. An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J Leukoc Biol. 2008 Oct; 84(4):1101-8. Handel TM, Johnson Z, Rodrigues DH, Dos Santos AC, Cirillo R, Muzio V, Riva S, Mack M, Déruaz M, Borlat F, Vitte PA, Wells TN, Teixeira MM, Proudfoot AE. PMID: 18662971; PMCID: PMC2538597.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCellsPHPublic Health
    95. Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J Mol Biol. 2008 Oct 24; 382(5):1265-75. Reynolds KA, Hanes MS, Thomson JM, Antczak AJ, Berger JM, Bonomo RA, Kirsch JF, Handel TM. PMID: 18775544; PMCID: PMC4085744.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    96. Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J Immunol. 2008 Mar 01; 180(5):3447-56. Shahrara S, Proudfoot AE, Park CC, Volin MV, Haines GK, Woods JM, Aikens CH, Handel TM, Pope RM. PMID: 18292571.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    97. Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J. 2008 Feb 01; 409(3):635-49. O'Hayre M, Salanga CL, Handel TM, Allen SJ. PMID: 18177271.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    98. Quantum mechanical design of enzyme active sites. J Org Chem. 2008 Feb 01; 73(3):889-99. Zhang X, DeChancie J, Gunaydin H, Chowdry AB, Clemente FR, Smith AJ, Handel TM, Houk KN. PMID: 18179229.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    99. An object-oriented library for computational protein design. J Comput Chem. 2007 Nov 15; 28(14):2378-88. Chowdry AB, Reynolds KA, Hanes MS, Voorhies M, Pokala N, Handel TM. PMID: 17471459.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    100. NMR assignment of human chemerin, a novel chemoattractant. Biomol NMR Assign. 2007 Dec; 1(2):171-3. Allen SJ, Zabel BA, Kirkpatrick J, Butcher EC, Nietlispach D, Handel TM. PMID: 19636857.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    101. Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007 Apr; 16(4):695-703. Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. PMID: 17384234; PMCID: PMC2203349.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    102. Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. J Immunol. 2007 Mar 15; 178(6):3713-20. Kulig P, Zabel BA, Dubin G, Allen SJ, Ohyama T, Potempa J, Handel TM, Butcher EC, Cichy J. PMID: 17339469.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    103. Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol. 2007; 25:787-820. Allen SJ, Crown SE, Handel TM. PMID: 17291188.
      View in: PubMed   Mentions: 302     Fields:    Translation:HumansAnimalsCells
    104. Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol. 2006 Aug; 34(8):1021-32. Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, Butcher EC. PMID: 16863908.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    105. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp Hematol. 2006 Aug; 34(8):1106-14. Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. PMID: 16863918.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    106. Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 08; 281(36):26745-53. Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. PMID: 16809340.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    107. Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. J Biol Chem. 2006 Sep 01; 281(35):25438-46. Crown SE, Yu Y, Sweeney MD, Leary JA, Handel TM. PMID: 16803905.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    108. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem. 2005 Oct 14; 280(41):34661-6. Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, Butcher EC. PMID: 16096270.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansCells
    109. Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry. J Biol Chem. 2005 Sep 16; 280(37):32200-8. Yu Y, Sweeney MD, Saad OM, Crown SE, Hsu AR, Handel TM, Leary JA. PMID: 16033763.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    110. Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine Growth Factor Rev. 2005 Dec; 16(6):625-36. Johnson Z, Proudfoot AE, Handel TM. PMID: 15990353.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    111. Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J. 2005 May; 19(7):761-72. Huang D, Wujek J, Kidd G, He TT, Cardona A, Sasse ME, Stein EJ, Kish J, Tani M, Charo IF, Proudfoot AE, Rollins BJ, Handel T, Ransohoff RM. PMID: 15857890.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    112. Chemokines bind to sulfatides as revealed by surface plasmon resonance. Biochim Biophys Acta. 2005 Feb 21; 1687(1-3):52-63. Sandhoff R, Grieshaber H, Djafarzadeh R, Sijmonsma TP, Proudfoot AE, Handel TM, Wiegandt H, Nelson PJ, Gröne HJ. PMID: 15708353.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    113. Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity. J Mol Biol. 2005 Mar 18; 347(1):203-27. Pokala N, Handel TM. PMID: 15733929.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    114. Regulation of protein function by glycosaminoglycans--as exemplified by chemokines. Annu Rev Biochem. 2005; 74:385-410. Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. PMID: 15952892.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    115. Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. J Biol Chem. 2004 May 21; 279(21):22294-305. Lau EK, Paavola CD, Johnson Z, Gaudry JP, Geretti E, Borlat F, Kungl AJ, Proudfoot AE, Handel TM. PMID: 15033992.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    116. Energy functions for protein design I: efficient and accurate continuum electrostatics and solvation. Protein Sci. 2004 Apr; 13(4):925-36. Pokala N, Handel TM. PMID: 15010542; PMCID: PMC2280065.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    117. Chemokine structure and receptor interactions. Ernst Schering Res Found Workshop. 2004; (45):101-24. Handel TM, Lau EK. PMID: 14699797.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    118. Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins. Adv Protein Chem. 2004; 68:351-91. Lau EK, Allen S, Hsu AR, Handel TM. PMID: 15500866.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    119. Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Lab Invest. 2004 Jan; 84(1):81-90. Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. PMID: 14647401.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    120. Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15137-42. Seet BT, McCaughan CA, Handel TM, Mercer A, Brunetti C, McFadden G, Fleming SB. PMID: 14657392; PMCID: PMC299921.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    121. Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1885-90. Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I, Borlat F, Wells TN, Kosco-Vilbois MH. PMID: 12571364; PMCID: PMC149928.
      View in: PubMed   Mentions: 310     Fields:    Translation:AnimalsCells
    122. Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell. 2002 Nov 01; 111(3):343-56. Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH. PMID: 12419245.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    123. Solution structure and dynamics of melanoma inhibitory activity protein. J Biomol NMR. 2002 Mar; 22(3):211-23. Lougheed JC, Domaille PJ, Handel TM. PMID: 11991352.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    124. Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9008-13. Seet BT, Singh R, Paavola C, Lau EK, Handel TM, McFadden G. PMID: 11470923; PMCID: PMC55364.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    125. Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine. J Biol Chem. 2001 Sep 07; 276(36):33906-14. Mizoue LS, Sullivan SK, King DS, Kledal TN, Schwartz TW, Bacon KB, Handel TM. PMID: 11432858.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    126. Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5515-20. Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM. PMID: 11331761; PMCID: PMC33244.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    127. Review: protein design--where we were, where we are, where we're going. J Struct Biol. 2001 May-Jun; 134(2-3):269-81. Pokala N, Handel TM. PMID: 11551185.
      View in: PubMed   Mentions: 26     Fields:    
    128. Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Chemistry. 2001 Mar 02; 7(5):1129-32. Marcaurelle LA, Mizoue LS, Wilken J, Oldham L, Kent SB, Handel TM, Bertozzi CR. PMID: 11303872.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    129. The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement. J Biol Chem. 2000 Jul 28; 275(30):23187-93. Hoover DM, Mizoue LS, Handel TM, Lubkowski J. PMID: 10770945.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    130. Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2. Biochemistry. 1999 Dec 07; 38(49):16167-77. Jarnagin K, Grunberger D, Mulkins M, Wong B, Hemmerich S, Paavola C, Bloom A, Bhakta S, Diehl F, Freedman R, McCarley D, Polsky I, Ping-Tsou A, Kosaka A, Handel TM. PMID: 10587439.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    131. Rotamer strain as a determinant of protein structural specificity. Protein Sci. 1999 Dec; 8(12):2598-610. Lazar GA, Johnson EC, Desjarlais JR, Handel TM. PMID: 10631975; PMCID: PMC2144231.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    132. Folding of an isolated ribonuclease H core fragment. Protein Sci. 1999 Nov; 8(11):2251-7. Chamberlain AK, Fischer KF, Reardon D, Handel TM, Marqusee AS. PMID: 10595528; PMCID: PMC2144208.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    133. Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2. Biochemistry. 1999 Oct 05; 38(40):13013-25. Hemmerich S, Paavola C, Bloom A, Bhakta S, Freedman R, Grunberger D, Krstenansky J, Lee S, McCarley D, Mulkins M, Wong B, Pease J, Mizoue L, Mirzadegan T, Polsky I, Thompson K, Handel TM, Jarnagin K. PMID: 10529171.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    134. Effect of hydrophobic core packing on sidechain dynamics. J Biomol NMR. 1999 Oct; 15(2):135-43. Johnson EC, Handel TM. PMID: 20872109.
      View in: PubMed   Mentions: 4     Fields:    
    135. Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin. Structure. 1999 Aug 15; 7(8):967-76. Johnson EC, Lazar GA, Desjarlais JR, Handel TM. PMID: 10467150.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    136. Side-chain and backbone flexibility in protein core design. J Mol Biol. 1999 Jul 02; 290(1):305-18. Desjarlais JR, Handel TM. PMID: 10388574.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    137. Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. Biochemistry. 1999 Feb 02; 38(5):1402-14. Mizoue LS, Bazan JF, Johnson EC, Handel TM. PMID: 9931005.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    138. Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. J Biol Chem. 1998 Dec 11; 273(50):33157-65. Paavola CD, Hemmerich S, Grunberger D, Polsky I, Bloom A, Freedman R, Mulkins M, Bhakta S, McCarley D, Wiesent L, Wong B, Jarnagin K, Handel TM. PMID: 9837883.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    139. Hydrophobic core packing and protein design. Curr Opin Chem Biol. 1998 Dec; 2(6):675-9. Lazar GA, Handel TM. PMID: 9914192.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    140. Characterization of a folding intermediate from HIV-1 ribonuclease H. Protein Sci. 1998 Oct; 7(10):2164-74. Kern G, Handel T, Marqusee S. PMID: 9792104; PMCID: PMC2143833.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    141. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 1998 Jun; 7(6):1404-14. Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. PMID: 9655345; PMCID: PMC2144029.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    142. Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. J Biomol NMR. 1997 Jul; 10(1):21-7. Davis JH, Agard DA, Handel TM, Basus VJ. PMID: 9335113.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    143. De novo design of the hydrophobic core of ubiquitin. Protein Sci. 1997 Jun; 6(6):1167-78. Lazar GA, Desjarlais JR, Handel TM. PMID: 9194177; PMCID: PMC2143711.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    144. Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. J Immunol. 1997 Feb 15; 158(4):1533-40. Hedrick JA, Saylor V, Figueroa D, Mizoue L, Xu Y, Menon S, Abrams J, Handel T, Zlotnik A. PMID: 9029087.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    145. Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region-helix-loop-helix domain of E47. Protein Sci. 1997 Jan; 6(1):175-84. Fairman R, Beran-Steed RK, Handel TM. PMID: 9007990; PMCID: PMC2143521.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    146. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan; 4(1):64-9. Lubkowski J, Bujacz G, Boqué L, Domaille PJ, Handel TM, Wlodawer A. PMID: 8989326.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    147. Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH. Nat Struct Biol. 1996 Sep; 3(9):782-7. Chamberlain AK, Handel TM, Marqusee S. PMID: 8784352.
      View in: PubMed   Mentions: 118     Fields:    Translation:Cells
    148. Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. Biochemistry. 1996 May 28; 35(21):6569-84. Handel TM, Domaille PJ. PMID: 8639605.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    149. De novo design of the hydrophobic cores of proteins. Protein Sci. 1995 Oct; 4(10):2006-18. Desjarlais JR, Handel TM. PMID: 8535237; PMCID: PMC2142989.
      View in: PubMed   Mentions: 80     Fields:    Translation:Cells
    150. New strategies in protein design. Curr Opin Biotechnol. 1995 Aug; 6(4):460-6. Desjarlais JR, Handel TM. PMID: 7579657.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    151. Metal ion-dependent modulation of the dynamics of a designed protein. Science. 1993 Aug 13; 261(5123):879-85. Handel TM, Williams SA, DeGrado WF. PMID: 8346440.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    152. Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3. Gene. 1993 Jun 15; 128(1):43-9. Hoess R, Brinkmann U, Handel T, Pastan I. PMID: 7685300.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    153. Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and gamma-ray perturbed angular correlation study. Biochim Biophys Acta. 1989 Apr 14; 980(2):234-40. Roerdink FH, Regts J, Handel T, Sullivan SM, Baldeschwieler JD, Scherphof GL. PMID: 2930790.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    154. Modification of lipid phase behavior with membrane-bound cryoprotectants. Biochim Biophys Acta. 1988 Feb 18; 938(2):143-54. Goodrich RP, Handel TM, Baldeschwieler JD. PMID: 3342228.
      View in: PubMed   Mentions: 3     Fields:    
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