Judith Varner

Title(s)Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailjvarner@ucsd.edu
ORCID ORCID Icon0000-0002-9251-0600 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Duke University, Durham, NCA.B. 1980Chemistry, with specialization in Biological Chemistry
    University of Basel, Basel, Switzerland Fulbright Fellowship 1981Biochemistry
    University of Basel, Basel, SwitzerlandPh.D.1988Biochemistry
    University of South Florida, St. Petersburg, FLPostdoctotrl studies1990Immunology
    UNiversity of North Carolina, Chapel Hill, Chapel Hill, NCPostdoctoral studies1993Cancer Biology/Pharmacology
    Collapse Awards and Honors
    Johns Hopkins University2023  - 2024Sidney Kimmel Cancer Center Visiting Professorship
    Curebound Foundation2023  - 2024Curebound Foundation Targeted Award
    Curebound Foundation2022  - 2023Curebound Foundation Discovery Award
    V Foundation2017  - 2020V Foundation Award For Translational Cancer Research
    American Association for Cancer Research2012  - 2014AACR-Landon Foundation Innovator Award for International Collaboration
    Lustgarten Foundation2011  - 2012Innovator Award

    Collapse Overview 
    Collapse Overview
    Judy Varner, Ph.D., is Professor in the Departments of Pathology and Medicine at the University of California, San Diego, recent Director of Faculty Mentoring for the Department of Pathology and co-Leader of the Solid Tumor Therapeutics program in the Moores UCSD Cancer Center. She joined the Department of Medicine in 1997 and the Department of Pathology in 2012. Dr. Varner received her undergraduate degree in Chemistry from Duke University, where she was an A.B. Duke and National Merit Scholar, and received her Ph.D. in Biochemistry from the University of Basel, Switzerland, where she was a Fulbright Fellow. Prior to coming to UCSD, she was a postdoctoral fellow in the Department of Pharmacology at the University of North Carolina at Chapel Hill where she studied integrin signaling in cancer. As a member of Moores Cancer Center, her research has focused on mechanisms regulating the tumor immune suppression and inflammation. Her work, which appears in journals that include Cancer Cell, Nature, Nature Communications and Cancer Discovery, has identified novel mechanisms by which macrophages promote tumor growth and has developed new approaches to treat cancer patients by targeting tumor macrophage signal transduction, with a focus on inhibition of PI3Kinase gamma. The novel therapeutic eganelisib (IPI-549) was developed by Infinity Pharmaceuticals in conjunction with the Varner lab and is currently in testing in Phase II and III clinical trials as an immune/oncology agent for cancer therapy. Dr. Varner is a recipient of the V Foundation Award for Translational Research, the AACR-Landon Foundation Innovator Award for International Collaboration and the Lustgarten Foundation Innovator Award for Pancreatic Cancer Research for her work on immune oncology therapeutics. Dr. Varner is active in the American Association for Cancer Research and the Society for the Immunotherapy of Cancer. Dr. Varner is organizer of the Myeloid Network, an international organization for the study of myeloid cell biology and therapeutics.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic Targeting of Macrophage PI3Kgamma in HNSCC
    NIH R01CA226909Apr 17, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Targeting the innate immune response in HNSCC
    NIH R01DE027325Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Role of PI3Kinase in Tumor Progression and Metastasis
    NIH R01CA167426Apr 1, 2012 - Mar 31, 2023
    Role: Principal Investigator
    The lymph node microenvionment in tumor metastasis
    NIH R01CA126820Jan 7, 2008 - Dec 31, 2014
    Role: Principal Investigator
    Negative Regulation of Cell Migration by PKA
    NIH R01CA098048Jun 25, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Fibronectin-binding integrins in angiogenesis
    NIH R01CA083133Sep 1, 1999 - Jun 30, 2011
    Role: Principal Investigator
    INTEGRIN A5B1 AND TUMOR CELL GROWTH
    NIH R01CA071619Apr 1, 1997 - Jan 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment. J Immunother Cancer. 2024 Aug 30; 12(8). O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. PMID: 39214650; PMCID: PMC11367338.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsCTClinical Trials
    2. PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med. 2024 Jul 03; 16(754):eadi6887. Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. PMID: 38959328; PMCID: PMC11272418.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma. Science. 2024 Jun 21; 384(6702):eade8520. Zak J, Pratumchai I, Marro BS, Marquardt KL, Zavareh RB, Lairson LL, Oldstone MBA, Varner JA, Hegerova L, Cao Q, Farooq U, Kenkre VP, Bachanova V, Teijaro JR. PMID: 38900864; PMCID: PMC11283877.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    4. PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer. J Exp Clin Cancer Res. 2024 Jun 01; 43(1):157. Curcio C, Mucciolo G, Roux C, Brugiapaglia S, Scagliotti A, Guadagnin G, Conti L, Longo D, Grosso D, Papotti MG, Hirsch E, Cappello P, Varner JA, Novelli F. PMID: 38824552; PMCID: PMC11143614.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. Blood. 2024 May 09; 143(19):1965-1979. Gu H, Chen C, Hou ZS, He XD, Xie S, Ni J, Qian C, Cheng X, Jiang T, Yang C, Roberts TM, Zheng J, Varner JA, Armstrong SA, Zhao JJ. PMID: 38271660; PMCID: PMC11103183.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Enzyme lights dual fires to promote cancer. Nature. 2023 05; 617(7959):42-43. Ghebremedhin A, Varner JA. PMID: 37076711.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation. Nat Commun. 2022 04 01; 13(1):1768. Schmid MC, Kang SW, Chen H, Paradise M, Ghebremedhin A, Kaneda MM, Chin SM, Do A, Watterson DM, Varner JA. PMID: 35365657; PMCID: PMC8975949.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242; PMCID: PMC8072253.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    9. Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression. Cancer Res. 2019 10 01; 79(19):5048-5059. Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. PMID: 31416839; PMCID: PMC6774806.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    10. Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Aug; 31(35):e1902952. Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. PMID: 31267590; PMCID: PMC6710136.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    11. MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene. 2019 07; 38(28):5599-5611. Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. PMID: 30967626; PMCID: PMC6625868.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    12. Targeting Tumor-Associated Macrophages in Cancer. Trends Immunol. 2019 04; 40(4):310-327. Pathria P, Louis TL, Varner JA. PMID: 30890304.
      View in: PubMed   Mentions: 426     Fields:    Translation:HumansAnimalsCells
    13. Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018 12 19; 9(1):5379. Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. PMID: 30568188; PMCID: PMC6300665.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    14. PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. Cancer Immunol Res. 2017 11; 5(11):957-968. Foubert P, Kaneda MM, Varner JA. PMID: 28963139; PMCID: PMC6422969.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    15. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18). Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    16. Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794; PMCID: PMC11075065.
      View in: PubMed   Mentions: 17     Fields:    
    17. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729; PMCID: PMC5479689.
      View in: PubMed   Mentions: 561     Fields:    Translation:HumansAnimalsCells
    18. PI3Kγ is a molecular switch that controls immune suppression. Nature | Article Accelerated Article Preview . 2016. Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Chris Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen & Judith A. Varner. . View Publication.
    19. Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. PMID: 27179037; PMCID: PMC5091937.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    20. Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discov. 2016 Mar; 6(3):270-85. Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. PMID: 26715645; PMCID: PMC4783268.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    21. Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815. Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900; PMCID: PMC4431816.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068; PMCID: PMC3670313.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    23. PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One. 2013; 8(4):e60226. Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PMID: 23565202; PMCID: PMC3614555.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    24. The primacy of β1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. PMID: 23056350; PMCID: PMC3463578.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    25. Myeloid cells in tumor inflammation. Vasc Cell. 2012 Sep 03; 4(1):14. Schmid MC, Varner JA. PMID: 22938502; PMCID: PMC3479419.
      View in: PubMed   Mentions: 31  
    26. Integrins in tumor angiogenesis and lymphangiogenesis. Methods Mol Biol. 2012; 757:471-86. Foubert P, Varner JA. PMID: 21909928; PMCID: PMC5433623.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    27. Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth. Cancer Res. 2011 Nov 15; 71(22):6965-75. Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA. PMID: 21948958; PMCID: PMC3249446.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    28. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146; PMCID: PMC3144144.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimals
    29. Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to vascular endothelial growth factor-C (VEGF-C). J Biol Chem. 2011 Apr 29; 286(17):14952-62. Yin X, Johns SC, Lawrence R, Xu D, Reddi K, Bishop JR, Varner JA, Fuster MM. PMID: 21343305; PMCID: PMC3083229.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    30. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. PMID: 20826718; PMCID: PMC3031419.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol. 2010; 2010:201026. Schmid MC, Varner JA. PMID: 20490273; PMCID: PMC2871549.
      View in: PubMed   Mentions: 89  
    32. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. PMID: 20388801; PMCID: PMC2856096.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    33. Circulating endothelial progenitor cells. Methods Mol Biol. 2009; 467:139-55. Schmid MC, Varner JA. PMID: 19301669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    34. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug; 8(8):604-17. Avraamides CJ, Garmy-Susini B, Varner JA. PMID: 18497750; PMCID: PMC2577722.
      View in: PubMed   Mentions: 442     Fields:    Translation:HumansAnimals
    35. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18599080; PMCID: PMC2628480.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    36. Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol. 2008; 6(3-4):155-63. Garmy-Susini B, Varner JA. PMID: 19093788; PMCID: PMC2837754.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008; 445:343-71. Schmid MC, Varner JA. PMID: 19022067.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007; 426:415-38. Garmy-Susini B, Makale M, Fuster M, Varner JA. PMID: 17697894.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    39. Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007; 39:122-129. Varner JA. PMID: 17314505.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. The sticky truth about angiogenesis and thrombospondins. J Clin Invest. 2006 Dec; 116(12):3111-3. Varner JA. PMID: 17143327; PMCID: PMC1678819.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007 May 18; 250(1):1-8. Schmid MC, Varner JA. PMID: 17049723; PMCID: PMC3167210.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    42. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun; 239(3):730-9. Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. PMID: 16714458.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    43. Circulating endothelial progenitor cells. Br J Cancer. 2005 Oct 17; 93(8):855-8. Garmy-Susini B, Varner JA. PMID: 16189517; PMCID: PMC2361665.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Integrins: roles in cancer development and as treatment targets. Br J Cancer. 2004 Feb 09; 90(3):561-5. Jin H, Varner J. PMID: 14760364; PMCID: PMC2410157.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansCells
    45. Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol. 2004 Jan; 11(1):4-12. Lucidarme O, Nguyen T, Kono Y, Corbeil J, Choi SH, Varner J, Mattrey RF. PMID: 14746396.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    46. The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 06; 279(6):4862-8. Boudreau NJ, Varner JA. PMID: 14610084.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    47. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. PMID: 12840057; PMCID: PMC162283.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    48. Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest. 2002 Oct; 110(7):933-41. Kim S, Bakre M, Yin H, Varner JA. PMID: 12370271; PMCID: PMC151143.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    49. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002 Sep; 8(9):995-1003. Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA. PMID: 12185361.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    50. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14. Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. PMID: 12124334.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    51. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res. 2002 Jul; 64(1):148-61. Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T. PMID: 12074641.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    52. Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist. Cancer Res. 2001 Mar 01; 61(5):2232-8. Kumar CC, Malkowski M, Yin Z, Tanghetti E, Yaremko B, Nechuta T, Varner J, Liu M, Smith EM, Neustadt B, Presta M, Armstrong L. PMID: 11280792.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    53. Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem. 2000 Oct 27; 275(43):33920-8. Kim S, Harris M, Varner JA. PMID: 10944524.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    54. A mathematical model of caspase function in apoptosis. Nat Biotechnol. 2000 Jul; 18(7):768-74. Fussenegger M, Bailey JE, Varner J. PMID: 10888847.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    55. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol. 2000 Apr; 156(4):1345-62. Kim S, Bell K, Mousa SA, Varner JA. PMID: 10751360; PMCID: PMC1876892.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    56. Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis. Adv Exp Med Biol. 2000; 476:169-80. Kumar CC, Armstrong L, Yin Z, Malkowski M, Maxwell E, Ling H, Yaremko B, Liu M, Varner J, Smith EM, Neustadt B, Nechuta T. PMID: 10949664.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    57. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999 Apr 16; 274(16):11101-9. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. PMID: 10196194.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis. 1999; 3(1):53-60. Varner JA, Nakada MT, Jordan RE, Coller BS. PMID: 14517444.
      View in: PubMed   Mentions: 19     Fields:    
    59. The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79:361-90. Varner JA. PMID: 9002227.
      View in: PubMed   Mentions: 10  Translation:HumansAnimals
    60. Integrins and cancer. Curr Opin Cell Biol. 1996 Oct; 8(5):724-30. Varner JA, Cheresh DA. PMID: 8939661.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    61. Isolation of a sponge-derived extracellular matrix adhesion protein. J Biol Chem. 1996 Jul 05; 271(27):16119-25. Varner JA. PMID: 8663195.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    62. Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996; 69-87. Varner JA, Cheresh DA. PMID: 8791129.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    63. Definition of two angiogenic pathways by distinct alpha v integrins. Science. 1995 Dec 01; 270(5241):1500-2. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. PMID: 7491498.
      View in: PubMed   Mentions: 306     Fields:    Translation:Animals
    64. REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun. 1995 Nov; 3(4):367-74. Varner JA, Brooks PC, Cheresh DA. PMID: 8821037.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    65. Cell adhesion in sponges: potentiation by a cell surface 68 kDa proteoglycan-binding protein. J Cell Sci. 1995 Sep; 108 ( Pt 9):3119-26. Varner JA. PMID: 8537451.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    66. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell. 1995 Jun; 6(6):725-40. Varner JA, Emerson DA, Juliano RL. PMID: 7579691; PMCID: PMC301232.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    67. Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol. 1993 Oct; 5(5):812-8. Juliano RL, Varner JA. PMID: 8240825.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    68. Functional role of the cytoplasmic domain of the integrin alpha 5 subunit. J Cell Biol. 1993 Jul; 122(1):209-21. Bauer JS, Varner J, Schreiner C, Kornberg L, Nicholas R, Juliano RL. PMID: 7686163; PMCID: PMC2119610.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    69. A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1746-50. Varner J, Neame P, Litman GW. PMID: 2000382; PMCID: PMC51101.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    70. Evolutionary development of immunoglobulin gene diversity. Adv Exp Med Biol. 1991; 292:11-7. Litman GW, Amemiya CT, Harding FA, Haire RN, Hinds KR, Litman RT, Ohta Y, Shamblott MJ, Varner JA. PMID: 1950762.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    71. Two cell surface proteins bind the sponge Microciona prolifera aggregation factor. J Biol Chem. 1988 Jun 15; 263(17):8498-508. Varner JA, Burger MM, Kaufman JF. PMID: 3372540.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    Judith's Networks
    Concepts (384)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (54)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCSD Profiles is managed by the UC San Diego Altman Clinical and Translational Research Institute (ACTRI).
    This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California