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Judith Varner

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentPathology
Address9500 Gilman Drive #0819
La Jolla CA 92093
Phone858-822-0086
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    Collapse Overview 
    Collapse Overview
    Research Interests
    Mechanisms regulating tumor angiogenesis, lymphangiogenesis, inflammation and metastasis.

    Education and Training
    AB - Chemistry, Duke University, Durham, NC - 1976-1980
    Fulbright Fellowship - University of Basel, Basel, Switzerland - 1980-1981
    PhD - University of Basel, Basel, Switzerland - 1981-1988
    Postdoctoral fellow - Dept. Molecular Genetics, Tampa Bay Research Institute - 1988-1990
    Postdoctoral fellow - Dept. Pharmacology, University of North Carolina, Chapel Hill - 1991-1993


    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic Targeting of Macrophage PI3Kgamma in HNSCC
    NIH/NCI R01CA226909Apr 17, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Targeting the innate immune response in HNSCC
    NIH/NIDCR R01DE027325Sep 15, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Role of PI3Kinase Gamma in Tumor Progression and Metastasis
    NIH/NCI R01CA167426Apr 1, 2012 - Mar 31, 2023
    Role: Principal Investigator
    The lymph node microenvionment in tumor metastasis
    NIH/NCI R01CA126820Jan 7, 2008 - Dec 31, 2014
    Role: Principal Investigator
    Negative Regulation of Cell Migration by PKA
    NIH/NCI R01CA098048Jun 25, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Fibronectin-binding integrins in angiogenesis
    NIH/NCI R01CA083133Sep 1, 1999 - Jun 30, 2011
    Role: Principal Investigator
    INTEGRIN A5B1 AND TUMOR CELL GROWTH
    NIH/NCI R01CA071619Apr 1, 1997 - Jan 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Foubert P, Kaneda MM, Varner JA. PI3K? Activates Integrin a4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. Cancer Immunol Res. 2017 Nov; 5(11):957-968. PMID: 28963139.
      View in: PubMed
    2. Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 Sep 21; 2(18). PMID: 28931759.
      View in: PubMed
    3. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. Corrigendum: PI3K? is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. PMID: 27974794.
      View in: PubMed
    4. Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Chris Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen & Judith A. Varner. PI3K? is a molecular switch that controls immune suppression. Nature | Article Accelerated Article Preview . 2016.
    5. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3K? is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. PMID: 27642729.
      View in: PubMed
    6. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. Macrophage PI3K? Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. PMID: 27179037.
      View in: PubMed
    7. Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discov. 2016 Mar; 6(3):270-85. PMID: 26715645; PMCID: PMC4783268.
    8. Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. Integrin a4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815. PMID: 25973900; PMCID: PMC4431816.
    9. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PI3Ka activates integrin a4ß1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. PMID: 23671068.
      View in: PubMed
    10. Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PI3-kinase ? promotes Rap1a-mediated activation of myeloid cell integrin a4ß1, leading to tumor inflammation and growth. PLoS One. 2013; 8(4):e60226. PMID: 23565202; PMCID: PMC3614555.
    11. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. The primacy of ß1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576. PMID: 23056350; PMCID: PMC3463578.
    12. Schmid MC, Varner JA. Myeloid cells in tumor inflammation. Vasc Cell. 2012 Sep 03; 4(1):14. PMID: 22938502; PMCID: PMC3479419.
    13. Foubert P, Varner JA. Integrins in tumor angiogenesis and lymphangiogenesis. Methods Mol Biol. 2012; 757:471-86. PMID: 21909928.
      View in: PubMed
    14. Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA. Combined blockade of integrin-a4ß1 plus cytokines SDF-1a or IL-1ß potently inhibits tumor inflammation and growth. Cancer Res. 2011 Nov 15; 71(22):6965-75. PMID: 21948958; PMCID: PMC3249446.
    15. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146; PMCID: PMC3144144.
    16. Yin X, Johns SC, Lawrence R, Xu D, Reddi K, Bishop JR, Varner JA, Fuster MM. Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to vascular endothelial growth factor-C (VEGF-C). J Biol Chem. 2011 Apr 29; 286(17):14952-62. PMID: 21343305; PMCID: PMC3083229.
    17. Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83. PMID: 20826718; PMCID: PMC3031419.
    18. Schmid MC, Varner JA. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol. 2010; 2010:201026. PMID: 20490273; PMCID: PMC2871549.
    19. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801; PMCID: PMC2856096.
    20. Schmid MC, Varner JA. Circulating endothelial progenitor cells. Methods Mol Biol. 2009; 467:139-55. PMID: 19301669.
      View in: PubMed
    21. Avraamides CJ, Garmy-Susini B, Varner JA. Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug; 8(8):604-17. PMID: 18497750; PMCID: PMC2577722.
    22. McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73. PMID: 18599080; PMCID: PMC2628480.
    23. Garmy-Susini B, Varner JA. Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol. 2008; 6(3-4):155-63. PMID: 19093788; PMCID: PMC2837754.
    24. Schmid MC, Varner JA. Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008; 445:343-71. PMID: 19022067.
      View in: PubMed
    25. Garmy-Susini B, Makale M, Fuster M, Varner JA. Methods to study lymphatic vessel integrins. Methods Enzymol. 2007; 426:415-38. PMID: 17697894.
      View in: PubMed
    26. Varner JA. Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007; 39:122-9. PMID: 17314505.
      View in: PubMed
    27. Varner JA. The sticky truth about angiogenesis and thrombospondins. J Clin Invest. 2006 Dec; 116(12):3111-3. PMID: 17143327; PMCID: PMC1678819.
    28. Schmid MC, Varner JA. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007 May 18; 250(1):1-8. PMID: 17049723; PMCID: PMC3167210.
    29. Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun; 239(3):730-9. PMID: 16714458.
      View in: PubMed
    30. Garmy-Susini B, Varner JA. Circulating endothelial progenitor cells. Br J Cancer. 2005 Oct 17; 93(8):855-8. PMID: 16189517; PMCID: PMC2361665.
    31. Lucidarme O, Nguyen T, Kono Y, Corbeil J, Choi SH, Varner J, Mattrey RF. Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol. 2004 Jan; 11(1):4-12. PMID: 14746396.
      View in: PubMed
    32. Boudreau NJ, Varner JA. The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 06; 279(6):4862-8. PMID: 14610084.
      View in: PubMed
    33. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41. PMID: 12840057; PMCID: PMC162283.
    34. Kim S, Bakre M, Yin H, Varner JA. Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest. 2002 Oct; 110(7):933-41. PMID: 12370271; PMCID: PMC151143.
    35. Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002 Sep; 8(9):995-1003. PMID: 12185361.
      View in: PubMed
    36. Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14. PMID: 12124334.
      View in: PubMed
    37. Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T. The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res. 2002 Jul; 64(1):148-61. PMID: 12074641.
      View in: PubMed
    38. Kim S, Harris M, Varner JA. Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem. 2000 Oct 27; 275(43):33920-8. PMID: 10944524.
      View in: PubMed
    39. Kim S, Bell K, Mousa SA, Varner JA. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol. 2000 Apr; 156(4):1345-62. PMID: 10751360; PMCID: PMC1876892.
    40. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999 Apr 16; 274(16):11101-9. PMID: 10196194.
      View in: PubMed
    41. Varner JA, Nakada MT, Jordan RE, Coller BS. Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis. 1999; 3(1):53-60. PMID: 14517444.
      View in: PubMed
    42. Varner JA. The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79:361-90. PMID: 9002227.
      View in: PubMed
    43. Varner JA, Cheresh DA. Integrins and cancer. Curr Opin Cell Biol. 1996 Oct; 8(5):724-30. PMID: 8939661.
      View in: PubMed
    44. Varner JA. Isolation of a sponge-derived extracellular matrix adhesion protein. J Biol Chem. 1996 Jul 05; 271(27):16119-25. PMID: 8663195.
      View in: PubMed
    45. Varner JA, Cheresh DA. Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996; 69-87. PMID: 8791129.
      View in: PubMed
    46. Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. Definition of two angiogenic pathways by distinct alpha v integrins. Science. 1995 Dec 01; 270(5241):1500-2. PMID: 7491498.
      View in: PubMed
    47. Varner JA, Brooks PC, Cheresh DA. REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun. 1995 Nov; 3(4):367-74. PMID: 8821037.
      View in: PubMed
    48. Varner JA. Cell adhesion in sponges: potentiation by a cell surface 68 kDa proteoglycan-binding protein. J Cell Sci. 1995 Sep; 108 ( Pt 9):3119-26. PMID: 8537451.
      View in: PubMed
    49. Varner JA, Emerson DA, Juliano RL. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell. 1995 Jun; 6(6):725-40. PMID: 7579691; PMCID: PMC301232.
    50. Juliano RL, Varner JA. Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol. 1993 Oct; 5(5):812-8. PMID: 8240825.
      View in: PubMed
    51. Litman GW, Amemiya CT, Harding FA, Haire RN, Hinds KR, Litman RT, Ohta Y, Shamblott MJ, Varner JA. Evolutionary development of immunoglobulin gene diversity. Adv Exp Med Biol. 1991; 292:11-7. PMID: 1950762.
      View in: PubMed
    52. Varner JA, Burger MM, Kaufman JF. Two cell surface proteins bind the sponge Microciona prolifera aggregation factor. J Biol Chem. 1988 Jun 15; 263(17):8498-508. PMID: 3372540.
      View in: PubMed