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Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment. J Immunother Cancer. 2024 Aug 30; 12(8).
O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. PMID: 39214650; PMCID: PMC11367338.
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Translation:
HumansCellsCTClinical Trials
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PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Sci Transl Med. 2024 Jul 03; 16(754):eadi6887.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. PMID: 38959328; PMCID: PMC11272418.
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HumansAnimalsCells
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JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma. Science. 2024 Jun 21; 384(6702):eade8520.
Zak J, Pratumchai I, Marro BS, Marquardt KL, Zavareh RB, Lairson LL, Oldstone MBA, Varner JA, Hegerova L, Cao Q, Farooq U, Kenkre VP, Bachanova V, Teijaro JR. PMID: 38900864; PMCID: PMC11283877.
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PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer. J Exp Clin Cancer Res. 2024 Jun 01; 43(1):157.
Curcio C, Mucciolo G, Roux C, Brugiapaglia S, Scagliotti A, Guadagnin G, Conti L, Longo D, Grosso D, Papotti MG, Hirsch E, Cappello P, Varner JA, Novelli F. PMID: 38824552; PMCID: PMC11143614.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway. Blood. 2024 May 09; 143(19):1965-1979.
Gu H, Chen C, Hou ZS, He XD, Xie S, Ni J, Qian C, Cheng X, Jiang T, Yang C, Roberts TM, Zheng J, Varner JA, Armstrong SA, Zhao JJ. PMID: 38271660; PMCID: PMC11103183.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Enzyme lights dual fires to promote cancer. Nature. 2023 05; 617(7959):42-43.
Ghebremedhin A, Varner JA. PMID: 37076711.
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Humans
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PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation. Nat Commun. 2022 04 01; 13(1):1768.
Schmid MC, Kang SW, Chen H, Paradise M, Ghebremedhin A, Kaneda MM, Chin SM, Do A, Watterson DM, Varner JA. PMID: 35365657; PMCID: PMC8975949.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021 04 20; 118(16).
Li J, Kaneda MM, Ma J, Li M, Shepard RM, Patel K, Koga T, Sarver A, Furnari F, Xu B, Dhawan S, Ning J, Zhu H, Wu A, You G, Jiang T, Venteicher AS, Rich JN, Glass CK, Varner JA, Chen CC. PMID: 33846242; PMCID: PMC8072253.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression. Cancer Res. 2019 10 01; 79(19):5048-5059.
Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA. PMID: 31416839; PMCID: PMC6774806.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA. Adv Mater. 2019 Aug; 31(35):e1902952.
Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ. PMID: 31267590; PMCID: PMC6710136.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene. 2019 07; 38(28):5599-5611.
Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. PMID: 30967626; PMCID: PMC6625868.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Targeting Tumor-Associated Macrophages in Cancer. Trends Immunol. 2019 04; 40(4):310-327.
Pathria P, Louis TL, Varner JA. PMID: 30890304.
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PubMed Mentions:
428 Fields:
Translation:
HumansAnimalsCells
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Integrin CD11b activation drives anti-tumor innate immunity. Nat Commun. 2018 12 19; 9(1):5379.
Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. PMID: 30568188; PMCID: PMC6300665.
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PubMed Mentions:
133 Fields:
Translation:
AnimalsCells
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PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. Cancer Immunol Res. 2017 11; 5(11):957-968.
Foubert P, Kaneda MM, Varner JA. PMID: 28963139; PMCID: PMC6422969.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21; 2(18).
Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE. PMID: 28931759; PMCID: PMC5621908.
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PubMed Mentions:
142 Fields:
Translation:
HumansAnimalsCells
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Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794; PMCID: PMC11075065.
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PubMed Mentions:
18 Fields:
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PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729; PMCID: PMC5479689.
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PubMed Mentions:
566 Fields:
Translation:
HumansAnimalsCells
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PI3Kγ is a molecular switch that controls immune suppression. Nature | Article Accelerated Article Preview . 2016.
Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Chris Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen & Judith A. Varner. . View Publication.
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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85.
Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. PMID: 27179037; PMCID: PMC5091937.
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PubMed Mentions:
155 Fields:
Translation:
HumansAnimalsCells
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Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer. Cancer Discov. 2016 Mar; 6(3):270-85.
Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM. PMID: 26715645; PMCID: PMC4783268.
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PubMed Mentions:
260 Fields:
Translation:
HumansAnimalsCells
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Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma. PLoS One. 2015; 10(5):e0120815.
Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG. PMID: 25973900; PMCID: PMC4431816.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7.
Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068; PMCID: PMC3670313.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimals
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PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth. PLoS One. 2013; 8(4):e60226.
Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA. PMID: 23565202; PMCID: PMC3614555.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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The primacy of β1 integrin activation in the metastatic cascade. PLoS One. 2012; 7(10):e46576.
Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ. PMID: 23056350; PMCID: PMC3463578.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Myeloid cells in tumor inflammation. Vasc Cell. 2012 Sep 03; 4(1):14.
Schmid MC, Varner JA. PMID: 22938502; PMCID: PMC3479419.
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PubMed Mentions:
31
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Integrins in tumor angiogenesis and lymphangiogenesis. Methods Mol Biol. 2012; 757:471-86.
Foubert P, Varner JA. PMID: 21909928; PMCID: PMC5433623.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth. Cancer Res. 2011 Nov 15; 71(22):6965-75.
Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA. PMID: 21948958; PMCID: PMC3249446.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27.
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. PMID: 21665146; PMCID: PMC3144144.
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PubMed Mentions:
201 Fields:
Translation:
HumansAnimals
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Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to vascular endothelial growth factor-C (VEGF-C). J Biol Chem. 2011 Apr 29; 286(17):14952-62.
Yin X, Johns SC, Lawrence R, Xu D, Reddi K, Bishop JR, Varner JA, Fuster MM. PMID: 21343305; PMCID: PMC3083229.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 2010 Dec 16; 116(25):5773-83.
Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. PMID: 20826718; PMCID: PMC3031419.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol. 2010; 2010:201026.
Schmid MC, Varner JA. PMID: 20490273; PMCID: PMC2871549.
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PubMed Mentions:
89
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Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51.
Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. PMID: 20388801; PMCID: PMC2856096.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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Circulating endothelial progenitor cells. Methods Mol Biol. 2009; 467:139-55.
Schmid MC, Varner JA. PMID: 19301669.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Integrins in angiogenesis and lymphangiogenesis. Nat Rev Cancer. 2008 Aug; 8(8):604-17.
Avraamides CJ, Garmy-Susini B, Varner JA. PMID: 18497750; PMCID: PMC2577722.
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PubMed Mentions:
444 Fields:
Translation:
HumansAnimals
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Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo. J Surg Res. 2009 Jan; 151(1):68-73.
McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M. PMID: 18599080; PMCID: PMC2628480.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Roles of integrins in tumor angiogenesis and lymphangiogenesis. Lymphat Res Biol. 2008; 6(3-4):155-63.
Garmy-Susini B, Varner JA. PMID: 19093788; PMCID: PMC2837754.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008; 445:343-71.
Schmid MC, Varner JA. PMID: 19022067.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Methods to study lymphatic vessel integrins. Methods Enzymol. 2007; 426:415-38.
Garmy-Susini B, Makale M, Fuster M, Varner JA. PMID: 17697894.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Stem cells and neurogenesis in tumors. Prog Exp Tumor Res. 2007; 39:122-129.
Varner JA. PMID: 17314505.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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The sticky truth about angiogenesis and thrombospondins. J Clin Invest. 2006 Dec; 116(12):3111-3.
Varner JA. PMID: 17143327; PMCID: PMC1678819.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007 May 18; 250(1):1-8.
Schmid MC, Varner JA. PMID: 17049723; PMCID: PMC3167210.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Angiogenesis: noninvasive quantitative assessment with contrast-enhanced functional US in murine model. Radiology. 2006 Jun; 239(3):730-9.
Lucidarme O, Kono Y, Corbeil J, Choi SH, Golmard JL, Varner J, Mattrey RF. PMID: 16714458.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Circulating endothelial progenitor cells. Br J Cancer. 2005 Oct 17; 93(8):855-8.
Garmy-Susini B, Varner JA. PMID: 16189517; PMCID: PMC2361665.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Integrins: roles in cancer development and as treatment targets. Br J Cancer. 2004 Feb 09; 90(3):561-5.
Jin H, Varner J. PMID: 14760364; PMCID: PMC2410157.
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PubMed Mentions:
187 Fields:
Translation:
HumansCells
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Angiogenesis model for ultrasound contrast research: exploratory study. Acad Radiol. 2004 Jan; 11(1):4-12.
Lucidarme O, Nguyen T, Kono Y, Corbeil J, Choi SH, Varner J, Mattrey RF. PMID: 14746396.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. J Biol Chem. 2004 Feb 06; 279(6):4862-8.
Boudreau NJ, Varner JA. PMID: 14610084.
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PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. J Clin Invest. 2003 Jul; 112(1):30-41.
Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. PMID: 12840057; PMCID: PMC162283.
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PubMed Mentions:
34 Fields:
Translation:
Animals
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Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest. 2002 Oct; 110(7):933-41.
Kim S, Bakre M, Yin H, Varner JA. PMID: 12370271; PMCID: PMC151143.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002 Sep; 8(9):995-1003.
Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA. PMID: 12185361.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res. 2002 Jul 15; 62(14):4007-14.
Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E. PMID: 12124334.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Microvasc Res. 2002 Jul; 64(1):148-61.
Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T. PMID: 12074641.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist. Cancer Res. 2001 Mar 01; 61(5):2232-8.
Kumar CC, Malkowski M, Yin Z, Tanghetti E, Yaremko B, Nechuta T, Varner J, Liu M, Smith EM, Neustadt B, Presta M, Armstrong L. PMID: 11280792.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimalsCells
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Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem. 2000 Oct 27; 275(43):33920-8.
Kim S, Harris M, Varner JA. PMID: 10944524.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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A mathematical model of caspase function in apoptosis. Nat Biotechnol. 2000 Jul; 18(7):768-74.
Fussenegger M, Bailey JE, Varner J. PMID: 10888847.
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PubMed Mentions:
82 Fields:
Translation:
HumansCells
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Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol. 2000 Apr; 156(4):1345-62.
Kim S, Bell K, Mousa SA, Varner JA. PMID: 10751360; PMCID: PMC1876892.
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PubMed Mentions:
195 Fields:
Translation:
HumansAnimalsCells
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Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis. Adv Exp Med Biol. 2000; 476:169-80.
Kumar CC, Armstrong L, Yin Z, Malkowski M, Maxwell E, Ling H, Yaremko B, Liu M, Varner J, Smith EM, Neustadt B, Nechuta T. PMID: 10949664.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. J Biol Chem. 1999 Apr 16; 274(16):11101-9.
Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. PMID: 10196194.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis. 1999; 3(1):53-60.
Varner JA, Nakada MT, Jordan RE, Coller BS. PMID: 14517444.
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PubMed Mentions:
19 Fields:
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The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79:361-90.
Varner JA. PMID: 9002227.
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PubMed Mentions:
10 Translation:
HumansAnimals
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Integrins and cancer. Curr Opin Cell Biol. 1996 Oct; 8(5):724-30.
Varner JA, Cheresh DA. PMID: 8939661.
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PubMed Mentions:
122 Fields:
Translation:
HumansAnimalsCells
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Isolation of a sponge-derived extracellular matrix adhesion protein. J Biol Chem. 1996 Jul 05; 271(27):16119-25.
Varner JA. PMID: 8663195.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996; 69-87.
Varner JA, Cheresh DA. PMID: 8791129.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimals
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Definition of two angiogenic pathways by distinct alpha v integrins. Science. 1995 Dec 01; 270(5241):1500-2.
Friedlander M, Brooks PC, Shaffer RW, Kincaid CM, Varner JA, Cheresh DA. PMID: 7491498.
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PubMed Mentions:
307 Fields:
Translation:
Animals
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REVIEW: the integrin alpha V beta 3: angiogenesis and apoptosis. Cell Adhes Commun. 1995 Nov; 3(4):367-74.
Varner JA, Brooks PC, Cheresh DA. PMID: 8821037.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Cell adhesion in sponges: potentiation by a cell surface 68 kDa proteoglycan-binding protein. J Cell Sci. 1995 Sep; 108 ( Pt 9):3119-26.
Varner JA. PMID: 8537451.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell. 1995 Jun; 6(6):725-40.
Varner JA, Emerson DA, Juliano RL. PMID: 7579691; PMCID: PMC301232.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol. 1993 Oct; 5(5):812-8.
Juliano RL, Varner JA. PMID: 8240825.
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PubMed Mentions:
69 Fields:
Translation:
HumansAnimalsCells
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Functional role of the cytoplasmic domain of the integrin alpha 5 subunit. J Cell Biol. 1993 Jul; 122(1):209-21.
Bauer JS, Varner J, Schreiner C, Kornberg L, Nicholas R, Juliano RL. PMID: 7686163; PMCID: PMC2119610.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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A serum heterodimer from hagfish (Eptatretus stoutii) exhibits structural similarity and partial sequence identity with immunoglobulin. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1746-50.
Varner J, Neame P, Litman GW. PMID: 2000382; PMCID: PMC51101.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Evolutionary development of immunoglobulin gene diversity. Adv Exp Med Biol. 1991; 292:11-7.
Litman GW, Amemiya CT, Harding FA, Haire RN, Hinds KR, Litman RT, Ohta Y, Shamblott MJ, Varner JA. PMID: 1950762.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Two cell surface proteins bind the sponge Microciona prolifera aggregation factor. J Biol Chem. 1988 Jun 15; 263(17):8498-508.
Varner JA, Burger MM, Kaufman JF. PMID: 3372540.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells