Igor Grant

Title(s)Professor, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Biography

    Igor Grant, M.D., is Distinguished Professor in the Department of Psychiatry at the University of California, San Diego School of Medicine. Dr. Grant is a neuropsychiatrist who trained at the University of British Columbia and the University of Pennsylvania before joining UCSD. His research interests include the effects of various diseases, such as HIV/AIDS and abuse of drugs and alcohol on the brain and behavior, as well as the psychobiological effects of chronic stress on the elderly. As Director for the Center for Medicinal Cannabis Research (CMCR), he is also interested in the possible benefits and limitations of cannabis as a medicine. He is recipient of awards for excellence in teaching and his contributions to neuropsychology.

    Research Interests

    A major theme of Dr. Grant’s research concerns the effects of systemic and neurological diseases, as well as substance abuse, on brain function and structure. His current research focus is on the effects of HIV on the brain and the potential that abuse of certain drugs, such as methamphetamine, in combination with aging, produce accelerated CNS injury. His work is supported by multiple NIH awards, including a P50 Center from NIDA entitled, the Translational Methamphetamine AIDS Research Center (TMARC). His other major studies include the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study, the California NeuroAIDS Tissue Network, a project in St. Petersburg Russia on the effects of opioid withdrawal on HIV controls. He is also Co-Director of the HIV Neurobehavioral Research Center and Director of the Center for Medical Cannabis Research. His past work on brain and behavior has included long-term outcome studies with alcoholics, persons suffering from chronic obstructive pulmonary disease with hypoxia, multiple sclerosis, and traumatic brain injury.

    Another theme of Dr. Grant’s work has been on the effects of chronic stress on physiologic and behavioral function. The most recent work has focused on the chronic stress of caregiving for a dementia relative with studies on cardiovascular, inflammatory, and psychological effects of such caregiving. These studies have been funded by sequential awards from the National Institute on Aging.

    Clinical & Teaching Focus

    Dr. Grant has been involved in all levels of teaching at UCSD. He organized, and for many years led the UCSD School of Medicine’s course in Social and Behavioral Sciences, and currently teaches as a facilitator in the Mind, Brain, Behavior core course. He actively mentors graduate students in the SDSU/UCSD Joint Doctoral Program in Clinical Psychology and has served as dissertation chair for 32 trainees. He has also been a supervisor of postdoctoral trainees, medical students working on their Independent Study Project, and junior faculty.

    After being recruited to San Diego, Dr. Grant helped establish the first VA mental health clinic at the UCSD affiliated San Diego VA Medical Center. Thereafter, he served as Director of the Psychiatry Department’s Outpatient Clinic (Gifford Mental Health Clinic) and also as Head of the Consult/Liaison Service at the San Diego VA Medical Center.

    Currently, Dr. Grant’s clinical work is limited to periodic consultations on patients with complex neuropsychiatric problems where there is an interest to sort out the separate and combined effects of brain injury and psychopathology on behavior.

    Collapse Research 
    Collapse Research Activities and Funding
    Alcohol abstinence induced HPA & SAM dysregulation disrupts HIV virology control
    NIH R21AA026525Sep 10, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Obstructive Sleep Apnea Endotypes and Impact on Phenotypes of People Living with HIV
    NIH R01HL142114May 1, 2018 - Apr 30, 2022
    Role: Co-Principal Investigator
    Heroin abstinence induced HPA & SAM dysregulation disrupts HIV virologic control
    NIH R21DA036607Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    California NeuroAIDS Tissue Network
    NIH U24MH100928May 1, 2013 - Feb 28, 2023
    Role: Principal Investigator
    Role Description: In 2014 Dr. Grant transferred his role to multiple PIs David Moore and Cristian Achim.
    CNC HIV Anti-viral Therapy Effects Research (CHARTER) Extension
    NIH 271201000027C-1-0-1Sep 16, 2010 - Sep 15, 2015
    Role: Principal Investigator
    CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource
    NIH 271201000030C-0-0-1Sep 16, 2010 - Sep 15, 2015
    Role: Principal Investigator
    CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) as a Resource
    NIH 271201000030C-1-0-1Sep 16, 2010 - Sep 15, 2015
    Role: Principal Investigator
    CNS HIV ANTI-RETROVIRAL THERAPY EFFECTS RESEARCH (CHARTER) EXTENSION
    NIH 271201000036C-1-0-1Sep 16, 2010 - Sep 15, 2015
    Role: Principal Investigator
    Translational Methamphetamine AIDS Research Center (TMARC)
    NIH P50DA026306Dec 1, 2008 - Dec 31, 2019
    Role: Principal Investigator
    California NeuroAIDS Tissue Network (CNTN)
    NIH U01MH083506Jun 5, 2008 - Apr 30, 2013
    Role: Principal Investigator
    HIV Neurobehavioral Research Center
    NIH/NIMH P30MH062512Apr 15, 2006 - Mar 31, 2011
    Role: Principal Investigator
    San Diego EXPORT Comprehensive NCMHD Research Center
    NIH P60MD000220Sep 30, 2002 - Apr 30, 2013
    Role: Co-Investigator
    San Diego Export: An University Community Partnership E*
    NIH P60MD000263Sep 30, 2002 - Aug 31, 2008
    Role: Co-Investigator
    CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER)
    NIH N01MH22005-16-0-1Sep 10, 2002 - Aug 31, 2010
    Role: Principal Investigator
    HIV Neurobehavioral Research Center
    NIH P30MH062512Apr 24, 2001 - Jan 31, 2026
    Role: Principal Investigator
    NEUROAIDS: EFFECTS OF METHAMPHETAMINE AND HCV
    NIH P01DA012065Jul 1, 2000 - Apr 30, 2011
    Role: Principal Investigator
    California NeuroAIDS Tissue Network
    NIH R24MH059745Sep 30, 1998 - Mar 31, 2009
    Role: Principal Investigator
    Alzheimer Caregiver Coping: Mental and Physical Health
    NIH RF1AG015301Sep 30, 1997 - Jun 30, 2019
    Role: Principal Investigator
    Alzheimer Caregiver Coping: Mental and Physical Health
    NIH R01AG015301Sep 30, 1997 - Mar 31, 2013
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000827Jan 27, 1997 - Nov 30, 2010
    Role: Co-Investigator
    Center for AIDS Research
    NIH P30AI036214Apr 1, 1994 - Mar 31, 2023
    Role: Co-Investigator
    SCIENTIFIC AND TECHNICAL EVALUATION AWARD
    NIH U09MH049947Jan 15, 1992 - Oct 31, 1992
    Role: Principal Investigator
    AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    NIH P50MH047680Sep 30, 1990 - Aug 31, 2001
    Role: Co-Investigator
    HIV NEUROBEHAVIORAL RESEARCH CENTER
    NIH P50MH045294Jun 1, 1989 - Nov 30, 2000
    Role: Principal Investigator
    ALZHEIMER CAREGIVING COPING--MENTAL AND PHYSICAL HEALTH
    NIH R01MH042840Aug 1, 1988 - Jun 30, 1997
    Role: Principal Investigator
    NEUROPSYCHIATRIC SEQUELAE OF HTLV-III INFECTIONS
    NIH R01MH043298May 1, 1987 - Apr 30, 1992
    Role: Principal Investigator

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    1. Lewis Judd, M.D. Neuropsychopharmacology. 2019 05; 44(6):1175. Grant I, Braff D. PMID: 30846851.
      View in: PubMed   Mentions:    Fields:    
    2. Ralph M. Reitan: A Founding Father of Neuropsychology. Arch Clin Neuropsychol. 2015 Dec; 30(8):760-1. Grant I, Heaton RK. PMID: 26590078.
      View in: PubMed   Mentions:    Fields:    
    3. Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology. 2014 Jun 10; 82(23):2055-62. Grant I, Franklin DR, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK, CHARTER Group . PMID: 24814848.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansCells
    4. Foreword by Igor Grant, M.D., Director, Center for Medicinal Cannabis Research (CMCR). Neuropharmacology. 2005 Jun; 48(8):1067. Grant I. PMID: 15885715.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study. J Int Neuropsychol Soc. 2003 Jul; 9(5):679-89. Grant I, Gonzalez R, Carey CL, Natarajan L, Wolfson T. PMID: 12901774.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    6. Health consequences of Alzheimer's caregiving transitions: effects of placement and bereavement. Psychosom Med. 2002 May-Jun; 64(3):477-86. Grant I, Adler KA, Patterson TL, Dimsdale JE, Ziegler MG, Irwin MR. PMID: 12021421.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    7. Evaluating the neurocognitive complications of SLE. Lessons from HIV disease. Ann N Y Acad Sci. 1997 Aug 14; 823:18-43. Grant I, Heaton RK, Marcotte TD. PMID: 9292031.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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