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Paul Price

TitleEmeritus Professor
InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0368
La Jolla CA 92093
Phone858-534-2120
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    Collapse Research 
    Collapse Research Activities and Funding
    Initiation and Inhibition of Medial Artery Calcification
    NIH/NHLBI R01HL058090Jul 1, 1998 - Nov 30, 2010
    Role: Principal Investigator
    FUNCTION OF THE VITAMIN K-DEPENDENT BONE PROTEIN
    NIH/NIAMS R37AR027029May 1, 1980 - Apr 30, 1997
    Role: Principal Investigator
    FUNCTION OF THE VITAMIN K-DEPENDENT BONE PROTEIN
    NIH/NIAMS R01AR027029May 1, 1980 - Apr 30, 1991
    Role: Principal Investigator
    FUNCTION OF THE VITAMIN K DEPENDENT BONE PROTEIN
    NIH/NIADDK R01AM027029May 1, 1980 - Apr 30, 1986
    Role: Principal Investigator
    MATRIX GLA PROTEIN AND CARTILAGE CALCIFICATION
    NIH/NIAMS R01AR025921Jul 1, 1979 - Jun 30, 2003
    Role: Principal Investigator
    A NOVEL MARKER FOR BONE METABOLISM
    NIH/NIADDK R01AM025921Jul 1, 1979 - Nov 30, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen X, Head GP, Price P, Kerns DL, Rice ME, Huang F, Gilreath RT, Yang F. Fitness costs of Vip3A resistance in Spodoptera frugiperda on different hosts. Pest Manag Sci. 2018 Sep 21. PMID: 30242959.
      View in: PubMed
    2. Yang F, Kerns DL, Head GP, Price P, Huang F. Cross-resistance to purified Bt proteins, Bt corn and Bt cotton in a Cry2Ab2-corn resistant strain of Spodoptera frugiperda. Pest Manag Sci. 2017 Dec; 73(12):2495-2503. PMID: 28627124.
      View in: PubMed
    3. Acharya B, Head GP, Price PA, Huang F. Fitness costs and inheritance of Cry2Ab2 resistance in Spodoptera frugiperda (J.E. Smith). J Invertebr Pathol. 2017 Oct; 149:8-14. PMID: 28676378.
      View in: PubMed
    4. Yang S, Wang Q, Fedorova E, Liu J, Qin Q, Zheng Q, Price PA, Pan H, Wang D, Griffitts JS, Bisseling T, Zhu H. Microsymbiont discrimination mediated by a host-secreted peptide in Medicago truncatula. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6848-6853. PMID: 28607056.
      View in: PubMed
    5. Moar W, Khajuria C, Pleau M, Ilagan O, Chen M, Jiang C, Price P, McNulty B, Clark T, Head G. Cry3Bb1-Resistant Western Corn Rootworm, Diabrotica virgifera virgifera (LeConte) Does Not Exhibit Cross-Resistance to DvSnf7 dsRNA. PLoS One. 2017; 12(1):e0169175. PMID: 28060922.
      View in: PubMed
    6. Shabab M, Arnold MF, Penterman J, Wommack AJ, Bocker HT, Price PA, Griffitts JS, Nolan EM, Walker GC. Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247. Proc Natl Acad Sci U S A. 2016 09 06; 113(36):10157-62. PMID: 27551097; PMCID: PMC5018749 [Available on 03/06/17].
      View in: PubMed, PubMed Central
    7. Driver J, Price P, vanWesenbeeck I, Kaplan W, Holden L, Ross J, Landenberger B. Modeling duration of time lived in a residence, a community and mobility in rural areas of Merced and Ventura, California to assess potential health risks to airborne contaminants. Sci Total Environ. 2016 Nov 01; 569-570:861-868. PMID: 27436777.
      View in: PubMed
    8. Niu Y, Qureshi JA, Ni X, Head GP, Price PA, Meagher RL, Kerns D, Levy R, Yang X, Huang F. F2 screen for resistance to Bacillus thuringiensis Cry2Ab2-maize in field populations of Spodoptera frugiperda (Lepidoptera: Noctuidae) from the southern United States. J Invertebr Pathol. 2016 07; 138:66-72. PMID: 27311896.
      View in: PubMed
    9. Stasulli NM, Eichelberger KR, Price PA, Pechous RD, Montgomery SA, Parker JS, Goldman WE. Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague. MBio. 2015 Oct 13; 6(5):e01530-15. PMID: 26463167; PMCID: PMC4620470.
      View in: PubMed, PubMed Central
    10. Price PA, Tanner HR, Dillon BA, Shabab M, Walker GC, Griffitts JS. Rhizobial peptidase HrrP cleaves host-encoded signaling peptides and mediates symbiotic compatibility. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15244-9. PMID: 26401024; PMCID: PMC4679054.
      View in: PubMed, PubMed Central
    11. Lathem WW, Schroeder JA, Bellows LE, Ritzert JT, Koo JT, Price PA, Caulfield AJ, Goldman WE. Posttranscriptional regulation of the Yersinia pestis cyclic AMP receptor protein Crp and impact on virulence. MBio. 2014 Feb 11; 5(1):e01038-13. PMID: 24520064; PMCID: PMC3950509.
      View in: PubMed, PubMed Central
    12. Cavaco S, Williamson MK, Rosa J, Roberto V, Cordeiro O, Price PA, Leonor Cancela M, Laizé V, Simes DC. Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiol Biochem. 2014 Jun; 40(3):731-8. PMID: 24185858.
      View in: PubMed
    13. Pechous RD, Sivaraman V, Price PA, Stasulli NM, Goldman WE. Early host cell targets of Yersinia pestis during primary pneumonic plague. PLoS Pathog. 2013; 9(10):e1003679. PMID: 24098126; PMCID: PMC3789773.
      View in: PubMed, PubMed Central
    14. Viegas CS, Simes DC, Williamson MK, Cavaco S, Laizé V, Price PA, Cancela ML. Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. J Biol Chem. 2013 Sep 27; 288(39):27801-11. PMID: 23884418; PMCID: PMC3784696.
      View in: PubMed, PubMed Central
    15. Price PA, Jin J, Goldman WE. Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3083-8. PMID: 22308352; PMCID: PMC3286930.
      View in: PubMed, PubMed Central
    16. Chen PY, Toroian D, Price PA, McKittrick J. Minerals form a continuum phase in mature cancellous bone. Calcif Tissue Int. 2011 May; 88(5):351-61. PMID: 21274705; PMCID: PMC3075393.
      View in: PubMed, PubMed Central
    17. Bobrov AG, Kirillina O, Ryjenkov DA, Waters CM, Price PA, Fetherston JD, Mack D, Goldman WE, Gomelsky M, Perry RD. Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis. Mol Microbiol. 2011 Jan; 79(2):533-51. PMID: 21219468; PMCID: PMC3058942.
      View in: PubMed, PubMed Central
    18. Weening EH, Cathelyn JS, Kaufman G, Lawrenz MB, Price P, Goldman WE, Miller VL. The dependence of the Yersinia pestis capsule on pathogenesis is influenced by the mouse background. Infect Immun. 2011 Feb; 79(2):644-52. PMID: 21115720; PMCID: PMC3028848.
      View in: PubMed, PubMed Central
    19. Johansen JS, Bojesen SE, Tybjaerg-Hansen A, Mylin AK, Price PA, Nordestgaard BG. Plasma YKL-40 and total and disease-specific mortality in the general population. Clin Chem. 2010 Oct; 56(10):1580-91. PMID: 20798353.
      View in: PubMed
    20. Viegas CS, Cavaco S, Neves PL, Ferreira A, João A, Williamson MK, Price PA, Cancela ML, Simes DC. Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am J Pathol. 2009 Dec; 175(6):2288-98. PMID: 19893032; PMCID: PMC2789615.
      View in: PubMed, PubMed Central
    21. Price PA, Toroian D, Lim JE. Mineralization by inhibitor exclusion: the calcification of collagen with fetuin. J Biol Chem. 2009 Jun 19; 284(25):17092-101. PMID: 19414589; PMCID: PMC2719347.
      View in: PubMed, PubMed Central
    22. Shea MK, O'Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr. 2009 Jun; 89(6):1799-807. PMID: 19386744; PMCID: PMC2682995.
      View in: PubMed, PubMed Central
    23. Ix JH, Wassel CL, Bauer DC, Toroian D, Tylavsky FA, Cauley JA, Harris TB, Price PA, Cummings SR, Shlipak MG. Fetuin-A and BMD in older persons: the Health Aging and Body Composition (Health ABC) study. J Bone Miner Res. 2009 Mar; 24(3):514-21. PMID: 19016589; PMCID: PMC2659522.
      View in: PubMed, PubMed Central
    24. Crosier MD, Booth SL, Peter I, Dawson-Hughes B, Price PA, O'Donnell CJ, Hoffmann U, Williamson MK, Ordovas JM. Matrix Gla protein polymorphisms are associated with coronary artery calcification in men. J Nutr Sci Vitaminol (Tokyo). 2009 Feb; 55(1):59-65. PMID: 19352064; PMCID: PMC2706526.
      View in: PubMed, PubMed Central
    25. Høgdall EV, Ringsholt M, Høgdall CK, Christensen IJ, Johansen JS, Kjaer SK, Blaakaer J, Ostenfeld-Møller L, Price PA, Christensen LH. YKL-40 tissue expression and plasma levels in patients with ovarian cancer. BMC Cancer. 2009 Jan 09; 9:8. PMID: 19134206; PMCID: PMC2645422.
      View in: PubMed, PubMed Central
    26. Price PA, Toroian D, Chan WS. Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralization. J Biol Chem. 2009 Feb 13; 284(7):4594-604. PMID: 19098289.
      View in: PubMed
    27. Johansen JS, Bojesen SE, Mylin AK, Frikke-Schmidt R, Price PA, Nordestgaard BG. Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population. J Clin Oncol. 2009 Feb 01; 27(4):572-8. PMID: 19075264.
      View in: PubMed
    28. Viegas CS, Simes DC, Laizé V, Williamson MK, Price PA, Cancela ML. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008 Dec 26; 283(52):36655-64. PMID: 18836183; PMCID: PMC2605998.
      View in: PubMed, PubMed Central
    29. Nøjgaard C, Høst NB, Christensen IJ, Poulsen SH, Egstrup K, Price PA, Johansen JS. Serum levels of YKL-40 increases in patients with acute myocardial infarction. Coron Artery Dis. 2008 Jun; 19(4):257-63. PMID: 18480670.
      View in: PubMed
    30. Roslind A, Johansen JS, Christensen IJ, Kiss K, Balslev E, Nielsen DL, Bentzen J, Price PA, Andersen E. High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival. Int J Cancer. 2008 Feb 15; 122(4):857-63. PMID: 17957792.
      View in: PubMed
    31. Roslind A, Knoop AS, Jensen MB, Johansen JS, Nielsen DL, Price PA, Balslev E. YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer. Breast Cancer Res Treat. 2008 Nov; 112(2):275-85. PMID: 18157633.
      View in: PubMed
    32. Toroian D, Price PA. The essential role of fetuin in the serum-induced calcification of collagen. Calcif Tissue Int. 2008 Feb; 82(2):116-26. PMID: 18097630.
      View in: PubMed
    33. Roslind A, Johansen JS, Junker N, Nielsen DL, Dzaferi H, Price PA, Balslev E. YKL-40 expression in benign and malignant lesions of the breast: a methodologic study. Appl Immunohistochem Mol Morphol. 2007 Dec; 15(4):371-81. PMID: 18091378.
      View in: PubMed
    34. Johansen JS, Høyer PE, Larsen LA, Price PA, Møllgård K. YKL-40 protein expression in the early developing human musculoskeletal system. J Histochem Cytochem. 2007 Dec; 55(12):1213-28. PMID: 17712177.
      View in: PubMed
    35. Toroian D, Lim JE, Price PA. The size exclusion characteristics of type I collagen: implications for the role of noncollagenous bone constituents in mineralization. J Biol Chem. 2007 Aug 03; 282(31):22437-47. PMID: 17562713.
      View in: PubMed
    36. Johansen JS, Brasso K, Iversen P, Teisner B, Garnero P, Price PA, Christensen IJ. Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival. Clin Cancer Res. 2007 Jun 01; 13(11):3244-9. PMID: 17545529.
      View in: PubMed
    37. Johansen JS, Jensen BV, Roslind A, Price PA. Is YKL-40 a new therapeutic target in cancer? Expert Opin Ther Targets. 2007 Feb; 11(2):219-34. PMID: 17227236.
      View in: PubMed
    38. Lathem WW, Price PA, Miller VL, Goldman WE. A plasminogen-activating protease specifically controls the development of primary pneumonic plague. Science. 2007 Jan 26; 315(5811):509-13. PMID: 17255510.
      View in: PubMed
    39. Ringsholt M, Høgdall EV, Johansen JS, Price PA, Christensen LH. YKL-40 protein expression in normal adult human tissues--an immunohistochemical study. J Mol Histol. 2007 Mar; 38(1):33-43. PMID: 17242979.
      View in: PubMed
    40. O'Donnell CJ, Shea MK, Price PA, Gagnon DR, Wilson PW, Larson MG, Kiel DP, Hoffmann U, Ferencik M, Clouse ME, Williamson MK, Cupples LA, Dawson-Hughes B, Booth SL. Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2769-74. PMID: 16973975; PMCID: PMC2562549.
      View in: PubMed, PubMed Central
    41. Price PA, Roublick AM, Williamson MK. Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate. Kidney Int. 2006 Nov; 70(9):1577-83. PMID: 16955099.
      View in: PubMed
    42. Brasso K, Christensen IJ, Johansen JS, Teisner B, Garnero P, Price PA, Iversen P. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate. 2006 Apr 01; 66(5):503-13. PMID: 16372331.
      View in: PubMed
    43. Laizé V, Viegas CS, Price PA, Cancela ML. Identification of an osteocalcin isoform in fish with a large acidic prodomain. J Biol Chem. 2006 Jun 02; 281(22):15037-43. PMID: 16565091.
      View in: PubMed
    44. Price PA, Chan WS, Jolson DM, Williamson MK. The elastic lamellae of devitalized arteries calcify when incubated in serum: evidence for a serum calcification factor. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1079-85. PMID: 16528009.
      View in: PubMed
    45. Johansen JS, Jensen BV, Roslind A, Nielsen D, Price PA. Serum YKL-40, a new prognostic biomarker in cancer patients? Cancer Epidemiol Biomarkers Prev. 2006 Feb; 15(2):194-202. PMID: 16492905.
      View in: PubMed
    46. Hjorth J, Watson D, Fynbo JP, Price PA, Jensen BL, Jørgensen UG, Kubas D, Gorosabel J, Jakobsson P, Sollerman J, Pedersen K, Kouveliotou C. The optical afterglow of the short gamma-ray burst GRB 050709. Nature. 2005 Oct 06; 437(7060):859-61. PMID: 16208365.
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    47. Laizé V, Martel P, Viegas CS, Price PA, Cancela ML. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005 Jul 22; 280(29):26659-68. PMID: 15849363.
      View in: PubMed
    48. Frazão C, Simes DC, Coelho R, Alves D, Williamson MK, Price PA, Cancela ML, Carrondo MA. Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications. Biochemistry. 2005 Feb 01; 44(4):1234-42. PMID: 15667217.
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    49. Johansen JS, Drivsholm L, Price PA, Christensen IJ. High serum YKL-40 level in patients with small cell lung cancer is related to early death. Lung Cancer. 2004 Dec; 46(3):333-40. PMID: 15541818.
      View in: PubMed
    50. Johansen JS, Milman N, Hansen M, Garbarsch C, Price PA, Graudal N. Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? Respir Med. 2005 Apr; 99(4):396-402. PMID: 15763444.
      View in: PubMed
    51. Gravekamp C, Sypniewska R, Gauntt S, Tarango M, Price P, Reddick R. Behavior of metastatic and nonmetastatic breast tumors in old mice. Exp Biol Med (Maywood). 2004 Jul; 229(7):665-75. PMID: 15229361.
      View in: PubMed
    52. Price PA, June HH, Hamlin NJ, Williamson MK. Evidence for a serum factor that initiates the re-calcification of demineralized bone. J Biol Chem. 2004 Apr 30; 279(18):19169-80. PMID: 14978037.
      View in: PubMed
    53. Price PA, Williamson MK, Nguyen TM, Than TN. Serum levels of the fetuin-mineral complex correlate with artery calcification in the rat. J Biol Chem. 2004 Jan 16; 279(3):1594-600. PMID: 14578360.
      View in: PubMed
    54. Jensen BV, Johansen JS, Price PA. High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer. Clin Cancer Res. 2003 Oct 01; 9(12):4423-34. PMID: 14555515.
      View in: PubMed
    55. Høgdall EV, Johansen JS, Kjaer SK, Price PA, Christensen L, Blaakaer J, Bock JE, Glud E, Høgdall CK. High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Oncol Rep. 2003 Sep-Oct; 10(5):1535-8. PMID: 12883737.
      View in: PubMed
    56. Nøjgaard C, Johansen JS, Christensen E, Skovgaard LT, Price PA, Becker U. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. J Hepatol. 2003 Aug; 39(2):179-86. PMID: 12873813.
      View in: PubMed
    57. Johansen JS, Christensen IJ, Riisbro R, Greenall M, Han C, Price PA, Smith K, Brünner N, Harris AL. High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival. Breast Cancer Res Treat. 2003 Jul; 80(1):15-21. PMID: 12889595.
      View in: PubMed
    58. Price PA, Lim JE. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem. 2003 Jun 13; 278(24):22144-52. PMID: 12676929.
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    59. Price PA, Nguyen TM, Williamson MK. Biochemical characterization of the serum fetuin-mineral complex. J Biol Chem. 2003 Jun 13; 278(24):22153-60. PMID: 12676928.
      View in: PubMed
    60. Dehn H, Høgdall EV, Johansen JS, Jørgensen M, Price PA, Engelholm SA, Høgdall CK. Plasma YKL-40, as a prognostic tumor marker in recurrent ovarian cancer. Acta Obstet Gynecol Scand. 2003 Mar; 82(3):287-93. PMID: 12694127.
      View in: PubMed
    61. Price PA, June HH, Buckley JR, Williamson MK. SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20; 91(6):547-52. PMID: 12242274.
      View in: PubMed
    62. Price PA, Omid N, Than TN, Williamson MK. The amino bisphosphonate ibandronate prevents calciphylaxis in the rat at doses that inhibit bone resorption. Calcif Tissue Int. 2002 Oct; 71(4):356-63. PMID: 12183764.
      View in: PubMed
    63. Cintin C, Johansen JS, Christensen IJ, Price PA, Sørensen S, Nielsen HJ. High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival. Cancer. 2002 Jul 15; 95(2):267-74. PMID: 12124825.
      View in: PubMed
    64. Price PA, Caputo JM, Williamson MK. Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: biochemical evidence for the cancellous bone-remodeling compartment. J Bone Miner Res. 2002 Jul; 17(7):1171-9. PMID: 12096831.
      View in: PubMed
    65. Østergaard C, Johansen JS, Benfield T, Price PA, Lundgren JD. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Clin Diagn Lab Immunol. 2002 May; 9(3):598-604. PMID: 11986266; PMCID: PMC119997.
      View in: PubMed, PubMed Central
    66. Kronborg G, Ostergaard C, Weis N, Nielsen H, Obel N, Pedersen SS, Price PA, Johansen JS. Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease. Scand J Infect Dis. 2002; 34(5):323-6. PMID: 12069012.
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    67. Price PA, Thomas GR, Pardini AW, Figueira WF, Caputo JM, Williamson MK. Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. J Biol Chem. 2002 Feb 08; 277(6):3926-34. PMID: 11724771.
      View in: PubMed
    68. Price PA, Buckley JR, Williamson MK. The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats. J Nutr. 2001 Nov; 131(11):2910-5. PMID: 11694617.
      View in: PubMed
    69. Price PA, June HH, Buckley JR, Williamson MK. Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol. 2001 Oct; 21(10):1610-6. PMID: 11597934.
      View in: PubMed
    70. Price PA, Faus SA, Williamson MK. Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol. 2001 May; 21(5):817-24. PMID: 11348880.
      View in: PubMed
    71. Price PA, Faus SA, Williamson MK. Warfarin-induced artery calcification is accelerated by growth and vitamin D. Arterioscler Thromb Vasc Biol. 2000 Feb; 20(2):317-27. PMID: 10669626.
      View in: PubMed
    72. Price PA, Faus SA, Williamson MK. Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. Arterioscler Thromb Vasc Biol. 1998 Sep; 18(9):1400-7. PMID: 9743228.
      View in: PubMed
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