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Giordano De Guglielmo

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
Phone858-246-5538
Emailgdeguglielmo@ucsd.edu
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    Collapse Biography 
    Collapse Education and Training
    University of Camerino, ItalyPharm D06/2009Pharmacy
    University of Camerino, ItalyPhD01/2013Physiology and Pharmacology
    The Scripps Research Institute, La Jolla03/2019Neuropharmacology
    Collapse Awards and Honors
    International School of Advanced Studies, University of Camerino, Camerino, Italy2010  - 2013PhD Fellowship
    Italian Society of Pharmacology2012Best oral presentation
    International School of Advanced Studies, Camerino, Italy2013SAS Award 2012 for PhD students demonstrating outstanding research performance
    “European Opioid Conference,” Guildford, United Kingdom2013Travel Award, “European Opioid Conference”
    “European Opioid Conference,” Guildford, United Kingdom2013Best Oral Presentation
    “Alcoholism and Stress: A Framework for Future Treatment Strategies” meeting, Volterra, Italy2014ERAB Travel Award
    “Alcoholism and Stress: A Framework for Future Treatment Strategies” meeting, Volterra, Italy2914Best Poster Presentation
    Research Society on Alcoholism conference2016Travel Award
    International Narcotics Research Conference 20182018Travel Award

    Collapse Overview 
    Collapse Overview
    My research program focuses on the neural circuits of addiction, with an emphasis on critical molecular and cellular mechanisms that are responsible for adverse behavioral outcomes that are associated with substance abuse and dependence. I have a broad background in neurobiology and neuropharmacology and am trained as a multidisciplinary scientist, with particular strengths in behavioral pharmacology and molecular biology.

    Collapse Research 
    Collapse Research Activities and Funding
    Cannabidiol as a strategy to treat alcohol dependence
    CMCR Nov 1, 2019 - Nov 1, 2021
    Role: Principal Investigator
    Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsive Oxycodone Intake in Outbred Rats
    NIH/NIDA U01DA044451Apr 1, 2018 - Jan 31, 2023
    Role: Co-Investigator
    Neuronal ensembles of compulsive alcohol drinking
    NIH/NIAAA R01AA026081Aug 1, 2017 - Jul 31, 2022
    Role: Co-Investigator
    Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake in Rats
    NIH/NIDA U01DA043799Apr 1, 2017 - Feb 28, 2022
    Role: Co-Investigator
    CNS Effects of Alcohol: Cellular Neurobiology
    NIH/NIAAA P60AA006420Dec 1, 1983 - Dec 31, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kallupi M, de Guglielmo G, Larrosa E, George O. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 Aug 26. PMID: 31462388.
      View in: PubMed
    2. Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 Aug 12. PMID: 31403700.
      View in: PubMed
    3. Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav. 2019 07; 18(6):e12577. PMID: 31012252.
      View in: PubMed
    4. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. PMID: 30886240.
      View in: PubMed
    5. Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 Sep 17; 8(1):13893. PMID: 30224774.
      View in: PubMed
    6. Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3). PMID: 29971251.
      View in: PubMed
    7. de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav. 2018 04; 167:36-41. PMID: 29505808.
      View in: PubMed
    8. Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140. PMID: 29354872.
      View in: PubMed
    9. Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895. PMID: 28833238.
      View in: PubMed
    10. de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 09; 362(3):378-384. PMID: 28645915.
      View in: PubMed
    11. Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R. Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption. Addict Biol. 2018 03; 23(2):585-595. PMID: 28635181.
      View in: PubMed
    12. Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017 04 26; 37(17):4593-4603. PMID: 28363981.
      View in: PubMed
    13. de Guglielmo G, Kallupi M, Cole MD, George O. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018. PMID: 28342089.
      View in: PubMed
    14. Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155. PMID: 27986929.
      View in: PubMed
    15. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. PMID: 27917870.
      View in: PubMed
    16. de Guglielmo G, Kallupi M, Scuppa G, Demopulos G, Gaitanaris G, Ciccocioppo R. Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents. Psychopharmacology (Berl). 2017 Jan; 234(2):223-234. PMID: 27714428.
      View in: PubMed
    17. de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53. PMID: 27605618.
      View in: PubMed
    18. Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R. Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction. Neuropsychopharmacology. 2017 02; 42(3):695-706. PMID: 27562376.
      View in: PubMed
    19. Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487. PMID: 26733798.
      View in: PubMed
    20. Ubaldi M, Giordano A, Severi I, Li H, Kallupi M, de Guglielmo G, Ruggeri B, Stopponi S, Ciccocioppo R, Cannella N. Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S. Biol Psychiatry. 2016 Mar 15; 79(6):452-62. PMID: 26055195.
      View in: PubMed
    21. Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53. PMID: 25878294.
      View in: PubMed
    22. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):1052. PMID: 25668637.
      View in: PubMed
    23. de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R. Analgesic tolerance to morphine is regulated by PPAR?. Br J Pharmacol. 2014 Dec; 171(23):5407-16. PMID: 25048682.
      View in: PubMed
    24. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PPAR? activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):927-37. PMID: 25311134.
      View in: PubMed
    25. de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F. MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol. 2015 Jul; 20(4):643-51. PMID: 24930632.
      View in: PubMed
    26. Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors. J Neurosci. 2014 Jan 08; 34(2):363-72. PMID: 24403138.
      View in: PubMed
    27. Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R. Activation of PPAR? by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcohol Clin Exp Res. 2013 Aug; 37(8):1351-60. PMID: 23550625.
      View in: PubMed
    28. Kallupi M, de Guglielmo G, Cannella N, Li HW, Caló G, Guerrini R, Ubaldi M, Renger JJ, Uebele VN, Ciccocioppo R. Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat. Psychopharmacology (Berl). 2013 Mar; 226(2):347-55. PMID: 23149909.
      View in: PubMed
    29. de Guglielmo G, Cippitelli A, Somaini L, Gerra G, Li H, Stopponi S, Ubaldi M, Kallupi M, Ciccocioppo R. Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat. Addict Biol. 2013 Jul; 18(4):644-53. PMID: 22734646.
      View in: PubMed
    30. Stopponi S, Somaini L, Cippitelli A, de Guglielmo G, Kallupi M, Cannella N, Gerra G, Massi M, Ciccocioppo R. Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. Psychopharmacology (Berl). 2012 Mar; 220(1):87-96. PMID: 21887495.
      View in: PubMed
    31. Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov; 43(7):491-8. PMID: 19913192.
      View in: PubMed