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Giordano De Guglielmo

Photo of Giordano De Guglielmo
Title(s)Assistant Professor In Residence, Psychiatry
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
Emailgdeguglielmo@ucsd.edu
ORCID ORCID Icon0000-0002-4782-7430 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Camerino, ItalyPharm D06/2009Pharmacy
    University of Camerino, ItalyPhD01/2013Physiology and Pharmacology
    The Scripps Research Institute, La Jolla03/2019Neuropharmacology
    Collapse awards and honors
    International School of Advanced Studies, University of Camerino, Camerino, Italy2010  - 2013PhD Fellowship
    Italian Society of Pharmacology2012Best oral presentation
    International School of Advanced Studies, Camerino, Italy2013SAS Award 2012 for PhD students demonstrating outstanding research performance
    “European Opioid Conference,” Guildford, United Kingdom2013Travel Award, “European Opioid Conference”
    “European Opioid Conference,” Guildford, United Kingdom2013Best Oral Presentation
    “Alcoholism and Stress: A Framework for Future Treatment Strategies” meeting, Volterra, Italy2014ERAB Travel Award
    “Alcoholism and Stress: A Framework for Future Treatment Strategies” meeting, Volterra, Italy2914Best Poster Presentation
    Research Society on Alcoholism conference2016Travel Award
    International Narcotics Research Conference 20182018Travel Award
    BBRF2020NARSAD Young Investigator Award

    Collapse Overview 
    Collapse overview
    My research program focuses on the neural circuits of addiction, with an emphasis on critical molecular and cellular mechanisms that are responsible for adverse behavioral outcomes that are associated with substance abuse and dependence. I have a broad background in neurobiology and neuropharmacology and am trained as a multidisciplinary scientist, with particular strengths in behavioral pharmacology and molecular biology.

    Collapse Research 
    Collapse research activities and funding
    Neuronal Ensembles of Opioid Withdrawal
    BBRF NARSAD Young Investigator AwardJan 1, 2021 - Dec 31, 2022
    Role: Principal Investigator
    Cannabidiol as a strategy to treat alcohol dependence
    CMCR Nov 1, 2019 - Nov 22, 2022
    Role: Principal Investigator
    Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsiveOxycodone Intake in Outbred Rats
    NIH U01DA044451Apr 1, 2018 - Jan 31, 2023
    Role: Co-Investigator
    Neuronal ensembles of compulsive alcohol drinking
    NIH R01AA026081Aug 1, 2017 - Jul 31, 2022
    Role: Co-Investigator
    Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake inRats
    NIH U01DA043799Apr 1, 2017 - Feb 28, 2022
    Role: Co-Investigator
    CNS Effects of Alcohol: Cellular Neurobiology
    NIH P60AA006420Dec 1, 1983 - Dec 31, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum. Neuropsychopharmacology. 2025 Jul 10. Dirik S, Doyle MR, Wood CP, Campo P, Martinez AR, Fannon M, Balaguer MG, Seely S, Montoya BA, Cook GMR, Palermo GM, Lin J, Sist MD, Naghshineh PK, Lan Z, Rahman SRMU, Suhandynata R, Schweitzer P, Kallupi M, de Guglielmo G. PMID: 40640509; PMCID: PMC12404032.
      View in: PubMed   Mentions:    Fields:    
    2. Perinatal fentanyl exposure drives enduring addiction risk and central amygdala gene dysregulation. Neuropharmacology. 2025 Nov 01; 278:110581. Wood CP, Shin Y, Balaguer MG, Campo P, Dirik S, Montoya BA, Cook GMR, Palermo GM, Naghshineh PK, Morgan A, Rahman SRMU, Palmer AA, Telese F, de Guglielmo G. PMID: 40582636; PMCID: PMC12377289.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Perinatal Fentanyl Exposure Drives Enduring Addiction Risk and Central Amygdala Gene Dysregulation. bioRxiv. 2025 May 25. Wood CP, Shin Y, Balaguer MG, Campo P, Dirik S, Montoya BA, Cook GMR, Palermo GM, Naghshineh PK, Morgan A, Rahman SRMU, Palmer AA, Telese F, de Guglielmo G. PMID: 40475641; PMCID: PMC12139761.
      View in: PubMed   Mentions:
    4. A Preclinical Alcohol BioBank: Samples from Behaviorally Characterized HS Rats for AUD Research. bioRxiv. 2025 May 07. Doyle MR, Campo P, Dirik S, Balaguer MG, Martinez AR, Kallupi M, de Guglielmo G. PMID: 40654864; PMCID: PMC12247670.
      View in: PubMed   Mentions:
    5. CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder. bioRxiv. 2025 May 04. Ghandour T, Glausier JR, Asok A, Doyle MR, Campo P, Colnaghi L, Lewis DA, Kandel DB, Kandel ER, de Guglielmo G, Carol Huang SS, Melas PA. PMID: 40458373; PMCID: PMC12129098.
      View in: PubMed   Mentions:
    6. Y and mitochondrial chromosomes in the heterogeneous stock rat population. G3 (Bethesda). 2024 Nov 06; 14(11). Okamoto F, Chitre AS, Missfeldt Sanches T, Chen D, Munro D, Aron AT, Beeson A, Bimschleger HV, Eid M, Garcia Martinez AG, Han W, Holl K, Jackson T, Johnson BB, King CP, Kuhn BN, Lamparelli AC, Netzley AH, Nguyen KH, Peng BF, Tripi JA, Wang T, Ziegler KS, Adams DJ, Baud A, Carrette LLG, Chen H, de Guglielmo G, Dorrestein P, George O, Ishiwari K, Jablonski MM, Jhou TC, Kallupi M, Knight R, Meyer PJ, Solberg Woods LC, Polesskaya O, Palmer AA. PMID: 39250761; PMCID: PMC11540319.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct. Elife. 2024 Nov 01; 12. de Guglielmo G, Carrette L, Kallupi M, Brennan M, Boomhower B, Maturin L, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Martinez AR, Velarde N, Othman D, Sichel B, Ramborger J, Lau J, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Bonnet-Zahedi S, Sneddon EA, Avelar A, Plasil SL, Mosquera J, Crook C, Chun L, Vang A, Milan KK, Schweitzer P, Lin B, Peng B, Chitre AS, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 39484794; PMCID: PMC11530236.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    8. Acute nicotine vapor normalizes sensorimotor gating and reduces locomotor activity deficits in HIV-1 transgenic rats. bioRxiv. 2024 Jun 22. Jha NA, Ayoub SM, Flesher MM, Morton K, Sikkink M, de Guglielmo G, Khokhar JY, Minassian A, Brody AL, Young JW. PMID: 38948796; PMCID: PMC11212989.
      View in: PubMed   Mentions:
    9. A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder. Neurobiol Stress. 2024 Mar; 29:100604. Mason BJ, Estey D, Roberts A, de Guglielmo G, George O, Light J, Stoolmiller M, Quello S, Skinner M, Shadan F, Begovic A, Kyle MC, Harris RA. PMID: 38292518; PMCID: PMC10825428.
      View in: PubMed   Mentions: 2  
    10. Catechol-O-Methyltransferase inhibition and alcohol use disorder: Evaluating the efficacy of tolcapone in ethanol-dependent rats. Neuropharmacology. 2024 01 01; 242:109770. Doyle MR, Dirik S, Martinez AR, Hughes TE, Iyer MR, Sneddon EA, Seo H, Cohen SM, de Guglielmo G. PMID: 37858886; PMCID: PMC10873029.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nat Neurosci. 2023 Nov; 26(11):1868-1879. Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. PMID: 37798411; PMCID: PMC10620093.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self-administration. Addict Biol. 2023 09; 28(9):e13316. Beldjoud H, Avelar A, de Guglielmo G, Kallupi M, Sedighim S, Velarde N, Boomhower B, Rizo N, Carrette LLG, George O. PMID: 37644893; PMCID: PMC10614571.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    13. Editorial: Opioids and opioid-use disorders. Front Pharmacol. 2023; 14:1227174. de Guglielmo G, Kallupi M, Cippitelli A, Caprioli D, Lutfy K. PMID: 37397475; PMCID: PMC10311202.
      View in: PubMed   Mentions: 1  
    14. Strain and sex-related behavioral variability of oxycodone dependence in rats. Neuropharmacology. 2023 10 01; 237:109635. Doyle MR, Martinez AR, Qiao R, Dirik S, Di Ottavio F, Pascasio G, Martin-Fardon R, Benner C, George O, Telese F, de Guglielmo G. PMID: 37327971; PMCID: PMC10353778.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    15. Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway. Biomedicines. 2023 May 05; 11(5). Kumaresan V, Lim Y, Juneja P, Tipton AE, de Guglielmo G, Carrette LLG, Kallupi M, Maturin L, Liu Y, George O, Zhang H. PMID: 37239038; PMCID: PMC10216163.
      View in: PubMed   Mentions: 3  
    16. Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II. Front Pharmacol. 2023; 14:1163991. Gonzalez-Cuevas G, Navarrete F, Garcia-Gutierrez MS, de Guglielmo G, Manzanares J. PMID: 36909164; PMCID: PMC9996324.
      View in: PubMed   Mentions:
    17. Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats. Neuropharmacology. 2023 01 01; 222:109309. de Guglielmo G, Simpson S, Kimbrough A, Conlisk D, Baker R, Cantor M, Kallupi M, George O. PMID: 36334765; PMCID: PMC10022477.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    18. Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum. Genes Brain Behav. 2022 09; 21(7):e12828. de Guglielmo G, Iemolo A, Nur A, Turner A, Montilla-Perez P, Martinez A, Crook C, Roberts A, Telese F. PMID: 35906757; PMCID: PMC9744517.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    19. Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Front Neurosci. 2022; 16:858427. Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. PMID: 35651629; PMCID: PMC9149415.
      View in: PubMed   Mentions: 15  
    20. Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats. Viruses. 2022 03 24; 14(4). Fu Y, Lorrai I, Zorman B, Mercatelli D, Shankula C, Marquez Gaytan J, Lefebvre C, de Guglielmo G, Kim HR, Sumazin P, Giorgi FM, Repunte-Canonigo V, Sanna PP. PMID: 35458399; PMCID: PMC9030762.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii). J Exp Anal Behav. 2022 05; 117(3):472-492. Gutierrez A, Creehan KM, de Guglielmo G, Roberts AJ, Taffe MA. PMID: 35261037; PMCID: PMC11528345.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    22. Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 06; 179(11):2589-2609. Laque A, Wagner GE, Matzeu A, De Ness GL, Kerr TM, Carroll AM, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou TC, Zorrilla EP, Martin-Fardon R, Koya E, Ritter RC, Weiss F, Suto N. PMID: 35023154; PMCID: PMC9081129.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. Front Behav Neurosci. 2022; 16:832899. Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. PMID: 35316955; PMCID: PMC8934439.
      View in: PubMed   Mentions: 6  
    24. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats. Brain Stimul. 2022 Jan-Feb; 15(1):13-22. Kallupi M, Kononoff J, Melas PA, Qvist JS, de Guglielmo G, Kandel ER, George O. PMID: 34742997; PMCID: PMC8816878.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    25. Editorial: Cannabidiol Treatment in Neurotherapeutic Interventions. Front Pharmacol. 2021; 12:752292. Gonzalez-Cuevas G, Garcia-Gutierrez MS, Navarrete F, de Guglielmo G, Manzanares J. PMID: 34733162; PMCID: PMC8558431.
      View in: PubMed   Mentions: 2  
    26. Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3423-3433. Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. PMID: 34415376; PMCID: PMC8889911.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    27. Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic Transmission. J Neurosci. 2021 Jul 14; 41(28):6128-6143. Ciccocioppo R, de Guglielmo G, Li HW, Melis M, Caffino L, Shen Q, Domi A, Fumagalli F, Demopulos GA, Gaitanaris GA. PMID: 34083258; PMCID: PMC8276738.
      View in: PubMed   Mentions: 2     Fields:    
    28. The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. eNeuro. 2021 May-Jun; 8(3). Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. PMID: 33875455; PMCID: PMC8213442.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    29. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 2021 05 01; 188:108510. McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. PMID: 33647278; PMCID: PMC8099171.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    30. OpenVape: An Open-Source E-Cigarette Vapor Exposure Device for Rodents. eNeuro. 2020 Sep/Oct; 7(5). Frie JA, Underhill J, Zhao B, de Guglielmo G, Tyndale RF, Khokhar JY. PMID: 32859723; PMCID: PMC7598908.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    31. Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. Neuropsychopharmacology. 2020 10; 45(11):1909-1919. Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. PMID: 32544927; PMCID: PMC7608444.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    32. Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. eNeuro. 2020 May/Jun; 7(3). Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. PMID: 32341122; PMCID: PMC7242819.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    33. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology (Berl). 2020 May; 237(5):1545-1555. Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. PMID: 32114633; PMCID: PMC7269712.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    34. Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Front Behav Neurosci. 2019; 13:292. de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. PMID: 31992976; PMCID: PMC6971096.
      View in: PubMed   Mentions: 24  
    35. Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2140-2148. Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. PMID: 31932450; PMCID: PMC6994987.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    36. Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Res. 2020 01 01; 1726:146502. de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Sanna PP. PMID: 31605699; PMCID: PMC7195807.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    37. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology. 2020 03; 45(4):579-588. Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. PMID: 31593982; PMCID: PMC7021713.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    38. Systemic Administration of the Cyclin-Dependent Kinase Inhibitor (S)-CR8 Selectively Reduces Escalated Ethanol Intake in Dependent Rats. Alcohol Clin Exp Res. 2019 10; 43(10):2079-2089. Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. PMID: 31403700; PMCID: PMC6779498.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 11; 29(11):1227-1234. Kallupi M, de Guglielmo G, Larrosa E, George O. PMID: 31462388; PMCID: PMC7899081.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    40. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav. 2019 07; 18(6):e12577. Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. PMID: 31012252; PMCID: PMC7891887.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    41. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. PMID: 30886240; PMCID: PMC6423296.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    42. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? Alcohol Alcohol. 2019 Jan 09; 54(5):497-502. Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP. PMID: 31535696; PMCID: PMC6751410.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    43. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 09 17; 8(1):13893. Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. PMID: 30224774; PMCID: PMC6141462.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    44. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3). Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. PMID: 29971251; PMCID: PMC6027959.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    45. Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacol Biochem Behav. 2018 04; 167:36-41. de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. PMID: 29505808; PMCID: PMC5866249.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    46. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140. Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. PMID: 29354872; PMCID: PMC8162771.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    47. CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895. Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. PMID: 28833238; PMCID: PMC5659873.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    48. Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats. J Pharmacol Exp Ther. 2017 09; 362(3):378-384. de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. PMID: 28645915; PMCID: PMC5539589.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    49. Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption. Addict Biol. 2018 03; 23(2):585-595. Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R. PMID: 28635181; PMCID: PMC5740020.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    50. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017 04 26; 37(17):4593-4603. Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. PMID: 28363981; PMCID: PMC5413190.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    51. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018. de Guglielmo G, Kallupi M, Cole MD, George O. PMID: 28342089; PMCID: PMC5658208.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    52. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. J Neurosci. 2017 02 01; 37(5):1139-1155. Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE. PMID: 27986929; PMCID: PMC5296793.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    53. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. PMID: 27917870; PMCID: PMC5520777.
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    54. Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents. Psychopharmacology (Berl). 2017 Jan; 234(2):223-234. de Guglielmo G, Kallupi M, Scuppa G, Demopulos G, Gaitanaris G, Ciccocioppo R. PMID: 27714428.
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    55. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. J Neurosci. 2016 09 07; 36(36):9446-53. de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. PMID: 27605618; PMCID: PMC5013191.
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    56. Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction. Neuropsychopharmacology. 2017 02; 42(3):695-706. Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R. PMID: 27562376; PMCID: PMC5240182.
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    57. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015; 9:487. Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. PMID: 26733798; PMCID: PMC4689854.
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    58. Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S. Biol Psychiatry. 2016 Mar 15; 79(6):452-62. Ubaldi M, Giordano A, Severi I, Li H, Kallupi M, de Guglielmo G, Ruggeri B, Stopponi S, Ciccocioppo R, Cannella N. PMID: 26055195.
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    59. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. J Neurosci. 2015 Apr 15; 35(15):6241-53. Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. PMID: 25878294; PMCID: PMC4397613.
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    60. PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):1052. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PMID: 25668637; PMCID: PMC4330520.
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    61. Analgesic tolerance to morphine is regulated by PPARγ. Br J Pharmacol. 2014 Dec; 171(23):5407-16. de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R. PMID: 25048682; PMCID: PMC4294048.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    62. PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):927-37. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PMID: 25311134; PMCID: PMC4330506.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    63. MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol. 2015 Jul; 20(4):643-51. de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F. PMID: 24930632; PMCID: PMC4268094.
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    64. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors. J Neurosci. 2014 Jan 08; 34(2):363-72. Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M. PMID: 24403138; PMCID: PMC3870926.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    65. Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcohol Clin Exp Res. 2013 Aug; 37(8):1351-60. Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R. PMID: 23550625.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    66. Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat. Psychopharmacology (Berl). 2013 Mar; 226(2):347-55. Kallupi M, de Guglielmo G, Cannella N, Li HW, Caló G, Guerrini R, Ubaldi M, Renger JJ, Uebele VN, Ciccocioppo R. PMID: 23149909.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    67. Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat. Addict Biol. 2013 Jul; 18(4):644-53. de Guglielmo G, Cippitelli A, Somaini L, Gerra G, Li H, Stopponi S, Ubaldi M, Kallupi M, Ciccocioppo R. PMID: 22734646.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsPHPublic Health
    68. Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. Psychopharmacology (Berl). 2012 Mar; 220(1):87-96. Stopponi S, Somaini L, Cippitelli A, de Guglielmo G, Kallupi M, Cannella N, Gerra G, Massi M, Ciccocioppo R. PMID: 21887495.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsPHPublic Health
    69. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov; 43(7):491-8. Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M. PMID: 19913192; PMCID: PMC2804869.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
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