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Robert Terkeltaub

Photo of Robert Terkeltaub
Title(s)Senate Emeritus, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse education and training
    McGill University, Montreal, CanadaMD1976Medicine
    McGill University, Montreal, CanadaDCS1972Biology

    Collapse Overview 
    Collapse overview
    Research Interests
    Cartilage nucleotide metabolism and disease; the regulation of proinflammatory cytokine expression in macrophages.

    Collapse Research 
    Collapse research activities and funding
    Novel Synovial Role in Pathogenesis of Gout
    NIH/NIAMS R21AR075990Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Rheumatic Diseases Research Training Grant
    NIH/NIAMS T32AR064194May 9, 2013 - Apr 30, 2024
    Role: Principal Investigator
    Innate Inflammation in Osteoarthritis
    VA I01BX001660Apr 1, 2012 - Mar 31, 2021
    Role: Principal Investigator
    Transglutaminase 2 in Arterial Calcification and Atherosclerosis
    NIH/NHLBI R01HL087252May 15, 2008 - Feb 28, 2012
    Role: Principal Investigator
    Chondrocyte S100/Calgranulins and RAGE in Osteoarthritis
    NIH/NIAMS R01AR054135Jun 1, 2006 - May 31, 2010
    Role: Principal Investigator
    ANK and Joint Ankylosis in Spondylitis
    NIH/NIAMS R01AR049366Jan 1, 2005 - Nov 30, 2008
    Role: Principal Investigator
    Molecular Mechanisms in Arterial Calcification
    NIH/NHLBI R01HL077360Jul 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    PTHRP 1 to 173 IN CHONDROCYTES
    NIH/NIAMS R01AR047347Apr 6, 2001 - Jan 31, 2006
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASE CENTER
    NIH P60AR040770Aug 1, 1991 - Feb 28, 2002
    Role: Co-Investigator
    Studies of Joint Aging and Osteoarthritis
    NIH P01AG007996Dec 1, 1988 - Apr 30, 2017
    Role: Co-Investigator
    LOW DENSITY LIPOPROTEIN AND INFLAMMATION
    NIH/NIDDK R01DK036702Jul 1, 1985 - Jun 30, 1996
    Role: Principal Investigator
    LOW DENSITY LIPOPROTEINS AND GOUT
    NIH/NIADDK R23AM036702Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator
    LOW DENSITY LIPOPROTEINS AND GOUT
    NIH/NIDDK R23DK036702Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Polyamine Takes the Fast Track to Attack Crystal-Induced Inflammation. Arthritis Rheumatol. 2025 Sep 22. Guma M, Terkeltaub R. PMID: 40977498.
      View in: PubMed   Mentions:    Fields:    
    2. Gut bacteria degrade purines via the 2,8-dioxopurine pathway. Nat Microbiol. 2025 Sep; 10(9):2291-2305. Liu Y, Zhou Z, Jarman JB, Chen H, Miranda-Velez M, Terkeltaub R, Dodd D. PMID: 40770490.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) definition of clinical remission in gout. Ann Rheum Dis. 2025 Jun 18. Tabi-Amponsah AD, Stewart S, Stamp LK, Taylor WJ, Terkeltaub R, Dalbeth N. PMID: 40537342.
      View in: PubMed   Mentions: 1     Fields:    
    4. Impact of adding urine alkalization therapy to xanthine oxidase inhibitor in gout management: a prospective cohort study. Rheumatology (Oxford). 2025 Jun 01; 64(6):3509-3517. Wang C, Guo K, Dalbeth N, Sun M, Lu J, Chen Y, Zhang H, Wang X, Ji X, Li X, Sun W, Han L, Cui L, Liu Z, Ji A, He Y, Terkeltaub R, Li C. PMID: 39932882; PMCID: PMC12107057.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease. Ann Rheum Dis. 2025 Jun; 84(6):1023-1032. Takei R, Rosenthal A, Pascart T, Reynolds RJ, Neogi T, Terkeltaub R, Tedeschi SK, Merriman TR. PMID: 40483170; PMCID: PMC12248263.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Association of Chronic Kidney Disease With Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout. Arthritis Care Res (Hoboken). 2025 Aug; 77(8):1022-1031. Kaneshita S, Fukui S, Niku S, Lee K, Belezzuoli E, Terkeltaub R, Guma M. PMID: 40176415.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Risk of Hepatotoxicity in Patients With Gout Treated With Febuxostat or Benzbromarone: A Propensity Score-Matched Cohort Study. Arthritis Care Res (Hoboken). 2025 Sep; 77(9):1149-1156. Sun W, Cui L, Terkeltaub R, Chen Y, Li X, Cheng X, Liu T, Dalbeth N, Li C. PMID: 40195679; PMCID: PMC12371309.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Pseudogout, chondrocalcinosis, CPPD et al: crystal clear… or clear as mud?-The time has come to reconsider the nomenclature of calcium pyrophosphate deposition. Ann Rheum Dis. 2025 Aug; 84(8):1287-1292. Sirotti S, Jauffret C, Adinolfi A, Cipolletta E, Cirillo D, Ingrao L, Lucia A, Filippucci E, Pascart T, Tedeschi SK, Terkeltaub R, Dalbeth N, Filippou G. PMID: 40312208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. An artificial intelligence-based gout management system reduced chronic kidney disease incident and improved target serum urate achievement. Rheumatology (Oxford). 2025 May 01; 64(5):3048-3056. Qi H, Lu J, Dalbeth N, Sun M, Liu Z, Ji X, Ji A, Wang C, Sun W, Li X, He Y, Cui L, Han L, Chen Y, Yan F, Zhang Y, Terkeltaub R, Li C. PMID: 39504469.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression. Immunity. 2025 Apr 08; 58(4):826-842.e8. Cobo I, Murillo-Saich J, Alishala M, Calderon S, Coras R, Hemming B, Inkum F, Rosas F, Takei R, Spann N, Prohaska TA, Alabarse PVG, Jeong SJ, Nickl CK, Cheng A, Li B, Vogel A, Weichhart T, Fuster JJ, Le T, Bradstreet TR, Webber AM, Edelson BT, Razani B, Ebert BL, Taneja R, Terkeltaub R, Bryan RL, Guma M, Glass CK. PMID: 40118070; PMCID: PMC12093573.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. The Gut Microbiome in Hyperuricemia and Gout. Arthritis Rheumatol. 2025 Aug; 77(8):955-965. Terkeltaub R, Dodd D. PMID: 39829115; PMCID: PMC12276925.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    12. Systematic literature review on Calcium Pyrophosphate Deposition (CPPD) nomenclature: condition elements and clinical states- A Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus project. RMD Open. 2025 Jan 30; 11(1). Jauffret C, Adinolfi A, Sirotti S, Cirillo D, Ingrao L, Lucia A, Cipolletta E, Filippucci E, Tedeschi S, Terkeltaub R, Dalbeth N, Pascart T, Filippou G. PMID: 39884730; PMCID: PMC11784236.
      View in: PubMed   Mentions: 1  Translation:Humans
    13. Target Serum Urate Achievement and Chronic Kidney Disease Progression in Patients With Gout and Kidney Disease. JAMA Intern Med. 2025 Jan 01; 185(1):74-82. Wang Y, Dalbeth N, Terkeltaub R, Zhang Y, Li X, Zeng C, Lei G, Wei J. PMID: 39585678; PMCID: PMC11589860.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement and inflammation modulators. Sci Rep. 2024 10 19; 14(1):24598. Sanchez C, Campeau A, Liu-Bryan R, Mikuls TR, O'Dell JR, Gonzalez DJ, Terkeltaub R. PMID: 39426967; PMCID: PMC11490615.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    15. Prediagnostic Amino Acid Metabolites and Risk of Gout, Accounting for Serum Urate: Prospective Cohort Study and Mendelian Randomization. Arthritis Care Res (Hoboken). 2024 Dec; 76(12):1666-1674. McCormick N, Joshi AD, Yokose C, Yu B, Tin A, Terkeltaub R, Merriman TR, Zeleznik O, Eliassen AH, Curhan GC, Ea HK, Nayor M, Raffield LM, Choi HK. PMID: 39169570; PMCID: PMC11711019.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort. Arthritis Rheumatol. 2025 Jan; 77(1):107-115. Ji A, Sui Y, Xue X, Ji X, Shi W, Shi Y, Terkeltaub R, Dalbeth N, Takei R, Yan F, Sun M, Li M, Lu J, Cui L, Liu Z, Wang C, Li X, Han L, Fang Z, Sun W, Liang Y, He Y, Zheng G, Wang X, Wang J, Zhang H, Pang L, Qi H, Li Y, Cheng Z, Li Z, Xiao J, Zeng C, Merriman TR, Qu H, Fang X, Li C. PMID: 39118347.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    17. Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort. Arthritis Rheumatol. 2024 Dec; 76(12):1780-1788. Pascart T, Latourte A, Tedeschi SK, Dalbeth N, Neogi T, Adinolfi A, Arad U, Andres M, Becce F, Bardin T, Cipolletta E, Ea HK, Filippou G, Filippucci E, FitzGerald J, Iagnocco A, Jansen TL, Janssen M, Lioté F, So A, McCarthy GM, Ramonda R, Richette P, Rosenthal A, Scirè C, Silvagni E, Sirotti S, Sivera F, Stamp LK, Taylor WJ, Terkeltaub R, Choi HK, Abhishek A. PMID: 39087364; PMCID: PMC11605267.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH. Life Metab. 2024 Oct; 3(5):loae018. Liang N, Yuan X, Zhang L, Shen X, Zhong S, Li L, Li R, Xu X, Chen X, Yin C, Guo S, Ge J, Zhu M, Tao Y, Chen S, Qian Y, Dalbeth N, Merriman TR, Terkeltaub R, Li C, Xia Q, Yin H. PMID: 39872146; PMCID: PMC11749550.
      View in: PubMed   Mentions: 4  
    19. Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement activation and inflammation modulators. Res Sq. 2024 May 09. Sanchez C, Campeau A, Liu-Bryan R, Mikuls TR, O'Dell JR, Gonzalez DJ, Terkeltaub R. PMID: 38766125; PMCID: PMC11100878.
      View in: PubMed   Mentions:
    20. Predictors of Inadequate Serum Urate Response to Low-Dose Febuxostat in Male Patients with Gout. J Inflamm Res. 2024; 17:2657-2668. Sun W, Zhao X, Dalbeth N, Terkeltaub R, Cui L, Liu Z, Han L, Wang C, Zhang H, Bao Y, Li C, Lu J. PMID: 38707960; PMCID: PMC11069377.
      View in: PubMed   Mentions:
    21. The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout. Rheumatology (Oxford). 2024 04 02; 63(4):1058-1067. Baraf HSB, Khanna PP, Kivitz AJ, Strand V, Choi HK, Terkeltaub R, Dalbeth N, DeHaan W, Azeem R, Traber PG, Keenan RT. PMID: 37449908; PMCID: PMC10986798.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    22. Hyperuricemia Subtypes Classified According to Renal Uric Acid Handling Manifesting Distinct Phenotypic and Genetic Profiles in People With Gout. Arthritis Rheumatol. 2024 Jul; 76(7):1130-1140. Qi H, Sun M, Terkeltaub R, Merriman TR, Chen H, Li Z, Ji A, Xue X, Sun W, Wang C, Li X, He Y, Cui L, Dalbeth N, Li C. PMID: 38412854.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target. Inflamm Res. 2024 May; 73(5):739-751. Alabarse PG, Oliveira P, Qin H, Yan T, Migaud M, Terkeltaub R, Liu-Bryan R. PMID: 38493256; PMCID: PMC11058052.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. The clinical benefits of sodium-glucose cotransporter type 2 inhibitors in people with gout. Nat Rev Rheumatol. 2024 Apr; 20(4):216-231. Yokose C, McCormick N, Abhishek A, Dalbeth N, Pascart T, Lioté F, Gaffo A, FitzGerald J, Terkeltaub R, Sise ME, Januzzi JL, Wexler DJ, Choi HK. PMID: 38472344.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Superiority of Low-Dose Benzbromarone Add-On to Low-Dose Febuxostat Compared With Febuxostat Monotherapy in Gout With Combined-Type Hyperuricemia. Arthritis Care Res (Hoboken). 2024 May; 76(5):703-711. Xue X, Sun M, Yan F, Dalbeth N, He Y, Li X, Qi H, Chen Y, Yuan X, Li M, Ji A, Terkeltaub R, Li C. PMID: 38130040; PMCID: PMC11039362.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Combination Treatment with Verinurad and Allopurinol in CKD: A Randomized Placebo and Active Controlled Trial. J Am Soc Nephrol. 2024 May 01; 35(5):594-606. Heerspink HJL, Stack AG, Terkeltaub R, Jongs N, Inker LA, Bjursell M, Maklad N, Perl S, Eklund O, Rikte T, Sjöström CD, Perkovic V, SAPPHIRE Investigators. PMID: 38564654; PMCID: PMC11149044.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Describing calcium pyrophosphate deposition: undoing the tower of Babel! Curr Opin Rheumatol. 2024 05 01; 36(3):241-250. Sirotti S, Terkeltaub R, Filippou G. PMID: 38517340.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Synthesis, Detection, and Metabolism of Pyridone Ribosides, Products of NAD Overoxidation. Chem Res Toxicol. 2024 02 19; 37(2):248-258. Hayat F, Deason JT, Bryan RL, Terkeltaub R, Song W, Kraus WL, Pluth J, Gassman NR, Migaud ME. PMID: 38198686; PMCID: PMC10880730.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Sustained xanthine oxidase inhibitor treat to target urate lowering therapy rewires a tight inflammation serum protein interactome. Res Sq. 2024 Jan 02. Sanchez C, Campeau A, Liu-Bryan R, Mikuls T, O'Dell J, Gonzalez D, Terkeltaub R. PMID: 38260556; PMCID: PMC10802734.
      View in: PubMed   Mentions:
    30. Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout. Arthritis Res Ther. 2023 12 11; 25(1):241. Qi H, Sun M, Terkeltaub R, Xue X, Li X, Cui L, He Y, Yan F, Sun R, Chen Y, Jia Z, Cheng X, Ma L, Liu T, Dalbeth N, Li C. PMID: 38082308; PMCID: PMC10712161.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. COVID-19 Vaccination and Gout Flare Risk in Patients With Infrequent or Frequent Flares: A Prospective Cohort Study. Arthritis Care Res (Hoboken). 2024 01; 76(1):131-139. He Y, Xue X, Dalbeth N, Terkeltaub R, Chen Y, Yan F, Pang L, Li X, Yuan X, Cheng X, Li C, Sun M. PMID: 37553607.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    32. Metabolomics and Machine Learning Identify Metabolic Differences and Potential Biomarkers for Frequent Versus Infrequent Gout Flares. Arthritis Rheumatol. 2023 12; 75(12):2252-2264. Wang M, Li R, Qi H, Pang L, Cui L, Liu Z, Lu J, Wang R, Hu S, Liang N, Tao Y, Dalbeth N, Merriman TR, Terkeltaub R, Yin H, Li C. PMID: 37390372.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation. Nat Biotechnol. 2023 Nov; 41(11):1656. Gauglitz JM, West KA, Bittremieux W, Williams CL, Weldon KC, Panitchpakdi M, Di Ottavio F, Aceves CM, Brown E, Sikora NC, Jarmusch AK, Martino C, Tripathi A, Meehan MJ, Dorrestein K, Shaffer JP, Coras R, Vargas F, Goldasich LD, Schwartz T, Bryant M, Humphrey G, Johnson AJ, Spengler K, Belda-Ferre P, Diaz E, McDonald D, Zhu Q, Elijah EO, Wang M, Marotz C, Sprecher KE, Vargas-Robles D, Withrow D, Ackermann G, Herrera L, Bradford BJ, Marques LMM, Amaral JG, Silva RM, Veras FP, Cunha TM, Oliveira RDR, Louzada-Junior P, Mills RH, Piotrowski PK, Servetas SL, Da Silva SM, Jones CM, Lin NJ, Lippa KA, Jackson SA, Daouk RK, Galasko D, Dulai PS, Kalashnikova TI, Wittenberg C, Terkeltaub R, Doty MM, Kim JH, Rhee KE, Beauchamp-Walters J, Wright KP, Dominguez-Bello MG, Manary M, Oliveira MF, Boland BS, Lopes NP, Guma M, Swafford AD, Dutton RJ, Knight R, Dorrestein PC. PMID: 37853256.
      View in: PubMed   Mentions: 4     Fields:    
    34. Emerging Urate-Lowering Drugs and Pharmacologic Treatment Strategies for Gout: A Narrative Review. Drugs. 2023 Nov; 83(16):1501-1521. Terkeltaub R. PMID: 37819612.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    35. The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease. Arthritis Rheumatol. 2023 10; 75(10):1703-1713. Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, Fuller A, Rosenthal A, Becce F, Bardin T, Ea HK, Filippou G, FitzGerald J, Iagnocco A, Lioté F, McCarthy GM, Ramonda R, Richette P, Sivera F, Andres M, Cipolletta E, Doherty M, Pascual E, Perez-Ruiz F, So A, Jansen TL, Kohler MJ, Stamp LK, Yinh J, Adinolfi A, Arad U, Aung T, Benillouche E, Bortoluzzi A, Dau J, Maningding E, Fang MA, Figus FA, Filippucci E, Haslett J, Janssen M, Kaldas M, Kimoto M, Leamy K, Navarro GM, Sarzi-Puttini P, Scirè C, Silvagni E, Sirotti S, Stack JR, Truong L, Xie C, Yokose C, Hendry AM, Terkeltaub R, Taylor WJ, Choi HK. PMID: 37494275; PMCID: PMC10543651.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    36. The 2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease. Ann Rheum Dis. 2023 10; 82(10):1248-1257. Abhishek A, Tedeschi SK, Pascart T, Latourte A, Dalbeth N, Neogi T, Fuller A, Rosenthal A, Becce F, Bardin T, Ea HK, Filippou G, Fitzgerald J, Iagnocco A, Lioté F, McCarthy GM, Ramonda R, Richette P, Sivera F, Andrés M, Cipolletta E, Doherty M, Pascual E, Perez-Ruiz F, So A, Jansen TL, Kohler MJ, Stamp LK, Yinh J, Adinolfi A, Arad U, Aung T, Benillouche E, Bortoluzzi A, Dau J, Maningding E, Fang MA, Figus FA, Filippucci E, Haslett J, Janssen M, Kaldas M, Kimoto M, Leamy K, Navarro GM, Sarzi-Puttini P, Scirè C, Silvagni E, Sirotti S, Stack JR, Truong L, Xie C, Yokose C, Hendry AM, Terkeltaub R, Taylor WJ, Choi HK. PMID: 37495237; PMCID: PMC10529191.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    37. Prediagnostic Glycoprotein Acetyl Levels and Incident and Recurrent Flare Risk Accounting for Serum Urate Levels: A Population-Based, Prospective Study and Mendelian Randomization Analysis. Arthritis Rheumatol. 2023 09; 75(9):1648-1657. Joshi AD, McCormick N, Yokose C, Yu B, Tin A, Terkeltaub R, Merriman TR, Eliassen AH, Curhan GC, Raffield LM, Choi HK. PMID: 37043280; PMCID: PMC10524152.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    38. Elevated serum CA72-4 predicts gout flares during urate lowering therapy initiation: a prospective cohort study. Rheumatology (Oxford). 2023 07 05; 62(7):2435-2443. Hu S, Sun M, Li M, Xue X, Terkeltaub R, Wang C, Wang M, Lu J, Ran Z, Li H, Ji A, Sun W, Li X, He Y, Liu Z, Zhang H, Wang X, Ji X, Dalbeth N, Li C. PMID: 36409036; PMCID: PMC10321093.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    39. Serum Urate-Lowering Efficacy and Safety of Tigulixostat in Gout Patients With Hyperuricemia: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Trial. Arthritis Rheumatol. 2023 07; 75(7):1275-1284. Terkeltaub R, Lee J, Min J, Shin S, Saag KG. PMID: 36649008.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    40. Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia. Arthritis Rheumatol. 2023 05; 75(5):794-805. Elsaid K, Merriman TR, Rossitto LA, Liu-Bryan R, Karsh J, Phipps-Green A, Jay GD, Elsayed S, Qadri M, Miner M, Cadzow M, Dambruoso TJ, Schmidt TA, Dalbeth N, Chhana A, Höglund J, Ghassemian M, Campeau A, Maltez N, Karlsson NG, Gonzalez DJ, Terkeltaub R. PMID: 36457235; PMCID: PMC10191887.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    41. Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy. 2023 08; 19(8):2257-2274. Li J, Zhou Y, Zhao W, Liu J, Ullah R, Fang P, Fang L, Xiao S. PMID: 36779599; PMCID: PMC10351467.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. [Determination of organophosphate diesters in facility vegetable soils using ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2023 Jan; 41(1):58-65. Liu M, Wang M, Zhao A, Zhu L, Wang C, Wei C, Liu W, Xu J. PMID: 36633077; PMCID: PMC9837671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    43. Superiority of Low-Dose Benzbromarone to Low-Dose Febuxostat in a Prospective, Randomized Comparative Effectiveness Trial in Gout Patients With Renal Uric Acid Underexcretion. Arthritis Rheumatol. 2022 12; 74(12):2015-2023. Yan F, Xue X, Lu J, Dalbeth N, Qi H, Yu Q, Wang C, Sun M, Cui L, Liu Z, He Y, Yuan X, Chen Y, Cheng X, Ma L, Li H, Ji A, Hu S, Ran Z, Terkeltaub R, Li C. PMID: 35795968; PMCID: PMC9771863.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    44. Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment. Rheumatol Adv Pract. 2022; 6(3):rkac086. Abhishek A, Fuller A, Nakafero G, Zhang W, Dumbleton J, Hawkey C, Coupland C, Terkeltaub R, Doherty M. PMID: 36407800; PMCID: PMC9667976.
      View in: PubMed   Mentions: 3  
    45. Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia. Nephrol Dial Transplant. 2022 07 26; 37(8):1461-1471. Heerspink HJL, Stack AG, Terkeltaub R, Greene TA, Inker LA, Bjursell M, Perl S, Rikte T, Erlandsson F, Perkovic V. PMID: 34383954; PMCID: PMC9317164.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
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    47. Proton-Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition in a Population-Based Study. Arthritis Care Res (Hoboken). 2022 12; 74(12):2059-2065. Liew JW, Peloquin C, Tedeschi SK, Felson DT, Zhang Y, Choi HK, Terkeltaub R, Neogi T. PMID: 35245410; PMCID: PMC9440954.
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    50. Palpable tophi and more comorbidities associated with adherence to urate-lowering medical therapy in a Chinese gout cohort. Joint Bone Spine. 2022 11; 89(6):105435. Hu S, Terkeltaub R, Sun M, Ji X, Li Z, Ran Z, Li Y, Zhang H, Sun W, Li C, Lu J. PMID: 35777552.
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    51. Cardiometabolic genomics and pharmacogenomics investigations in Filipino Americans: Steps towards precision health and reducing health disparities. Am Heart J Plus. 2022 Mar; 15. Roman YM, McClish D, Price ET, Sabo RT, Woodward OM, Mersha TB, Shah N, Armada A, Terkeltaub R. PMID: 35647570; PMCID: PMC9139029.
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    52. A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response. Geroscience. 2022 08; 44(4):2195-2211. Hilsabeck TAU, Liu-Bryan R, Guo T, Wilson KA, Bose N, Raftery D, Beck JN, Lang S, Jin K, Nelson CS, Oron T, Stoller M, Promislow D, Brem RB, Terkeltaub R, Kapahi P. PMID: 35381951; PMCID: PMC9616999.
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    53. Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination. Ann Rheum Dis. 2022 08; 81(8):1189-1193. Lu J, He Y, Terkeltaub R, Sun M, Ran Z, Xu X, Wang C, Li X, Hu S, Xue X, Yan F, Zhang H, Yin H, Shi Y, Dalbeth N, Li C. PMID: 35277390; PMCID: PMC9279754.
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    54. Association Between Gut Microbiota and Elevated Serum Urate in Two Independent Cohorts. Arthritis Rheumatol. 2022 04; 74(4):682-691. Wei J, Zhang Y, Dalbeth N, Terkeltaub R, Yang T, Wang Y, Yang Z, Li J, Wu Z, Zeng C, Lei G. PMID: 34725964.
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    55. Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell Rep. 2022 03 08; 38(10):110489. Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M. PMID: 35263587; PMCID: PMC8989403.
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    56. Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management. NEJM Evid. 2022 Mar; 1(3). O'Dell JR, Brophy MT, Pillinger MH, Neogi T, Palevsky PM, Wu H, Davis-Karim A, Newcomb JA, Ferguson R, Pittman D, Cannon GW, Taylor T, Terkeltaub R, Cannella AC, England BR, Helget LN, Mikuls TR. PMID: 35434725; PMCID: PMC9012032.
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    59. Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients. Front Endocrinol (Lausanne). 2021; 12:724822. Ran Z, Xue X, Han L, Terkeltaub R, Merriman TR, Zhao T, He Y, Wang C, Li X, Liu Z, Cui L, Li H, Ji A, Hu S, Lu J, Li C. PMID: 34594303; PMCID: PMC8476917.
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    60. Consensus Statement Regarding the Efficacy and Safety of Long-Term Low-Dose Colchicine in Gout and Cardiovascular Disease. Am J Med. 2022 01; 135(1):32-38. Robinson PC, Terkeltaub R, Pillinger MH, Shah B, Karalis V, Karatza E, Liew D, Imazio M, Cornel JH, Thompson PL, Nidorf M. PMID: 34416165; PMCID: PMC8688259.
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    61. Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout. Arthritis Rheumatol. 2021 09; 73(9):1738-1748. Shen X, Wang C, Liang N, Liu Z, Li X, Zhu ZJ, Merriman TR, Dalbeth N, Terkeltaub R, Li C, Yin H. PMID: 33760368.
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    62. Management of gout in chronic kidney disease: a G-CAN Consensus Statement on the research priorities. Nat Rev Rheumatol. 2021 10; 17(10):633-641. Stamp LK, Farquhar H, Pisaniello HL, Vargas-Santos AB, Fisher M, Mount DB, Choi HK, Terkeltaub R, Hill CL, Gaffo AL. PMID: 34331037; PMCID: PMC8458096.
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    63. A Randomized, Phase II Study Evaluating the Efficacy and Safety of Anakinra in the Treatment of Gout Flares. Arthritis Rheumatol. 2021 08; 73(8):1533-1542. Saag KG, Khanna PP, Keenan RT, Ohlman S, Osterling Koskinen L, Sparve E, Åkerblad AC, Wikén M, So A, Pillinger MH, Terkeltaub R. PMID: 33605029.
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    64. In Reply to 'Verinurad/Febuxostat and Nephrotoxicity'. Am J Kidney Dis. 2021 09; 78(3):468-469. Stack AG, Erlandsson F, Terkeltaub R. PMID: 34126126.
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    65. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) common language definition of gout. RMD Open. 2021 04; 7(2). Murdoch R, Barry MJ, Choi HK, Hernandez D, Johnsen B, Labrador M, Reid S, Singh JA, Terkeltaub R, Vázquez Mellado J, Dalbeth N. PMID: 33903281; PMCID: PMC8076916.
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    67. Oral Treatment With an Engineered Uricase, ALLN-346, Reduces Hyperuricemia, and Uricosuria in Urate Oxidase-Deficient Mice. Front Med (Lausanne). 2020; 7:569215. Pierzynowska K, Deshpande A, Mosiichuk N, Terkeltaub R, Szczurek P, Salido E, Pierzynowski S, Grujic D. PMID: 33330529; PMCID: PMC7732547.
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    69. Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
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    72. Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior. Arthritis Res Ther. 2020 02 22; 22(1):34. Li H, Ding X, Terkeltaub R, Lin H, Zhang Y, Zhou B, He K, Li K, Liu Z, Wei J, Yang Y, Xie H, Zeng C, Lei G. PMID: 32087740; PMCID: PMC7036179.
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    73. Patients Prescribed Anakinra for Acute Gout Have Baseline Increased Burden of Hyperuricemia, Tophi, and Comorbidities, and Ultimate All-Cause Mortality. Clin Med Insights Arthritis Musculoskelet Disord. 2019; 12:1179544119890853. Sharma E, Pedersen B, Terkeltaub R. PMID: 31839715; PMCID: PMC6902385.
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    75. Gout, Hyperuricaemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions of disease states of gout. Ann Rheum Dis. 2019 11; 78(11):1592-1600. Bursill D, Taylor WJ, Terkeltaub R, Abhishek A, So AK, Vargas-Santos AB, Gaffo AL, Rosenthal A, Tausche AK, Reginato A, Manger B, Sciré C, Pineda C, van Durme C, Lin CT, Yin C, Albert DA, Biernat-Kaluza E, Roddy E, Pascual E, Becce F, Perez-Ruiz F, Sivera F, Lioté F, Schett G, Nuki G, Filippou G, McCarthy G, da Rocha Castelar Pinheiro G, Ea HK, Tupinambá HA, Yamanaka H, Choi HK, Mackay J, ODell JR, Vázquez Mellado J, Singh JA, Fitzgerald JD, Jacobsson LTH, Joosten L, Harrold LR, Stamp L, Andrés M, Gutierrez M, Kuwabara M, Dehlin M, Janssen M, Doherty M, Hershfield MS, Pillinger M, Edwards NL, Schlesinger N, Kumar N, Slot O, Ottaviani S, Richette P, MacMullan PA, Chapman PT, Lipsky PE, Robinson P, Khanna PP, Gancheva RN, Grainger R, Johnson RJ, Te Kampe R, Keenan RT, Tedeschi SK, Kim S, Choi SJ, Fields TR, Bardin T, Uhlig T, Jansen T, Merriman T, Pascart T, Neogi T, Klück V, Louthrenoo W, Dalbeth N. PMID: 31501138; PMCID: PMC7288724.
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    76. Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares. Arthritis Rheumatol. 2019 09; 71(9):1580-1586. Zhang M, Zhang Y, Terkeltaub R, Chen C, Neogi T. PMID: 30908893; PMCID: PMC6717014.
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    77. Risk of gout flares after vaccination: a prospective case cross-over study. Ann Rheum Dis. 2019 11; 78(11):1601-1604. Yokose C, McCormick N, Chen C, Neogi T, Chaisson C, Terkeltaub R, Hunter DJ, Zhang Y, Choi H. PMID: 31366470; PMCID: PMC7184318.
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    78. Thiazide diuretics and risk of knee replacement surgery among patients with knee osteoarthritis: a general population-based cohort study. Osteoarthritis Cartilage. 2019 10; 27(10):1454-1461. Wei J, Neogi T, Terkeltaub R, Fenves AZ, Zeng C, Misra D, Choi HK, Lei G, Zhang Y. PMID: 31181261; PMCID: PMC11482426.
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    79. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
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    80. A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia. PLoS One. 2019; 14(4):e0212235. Serrano RL, Yu W, Graham RM, Bryan RL, Terkeltaub R. PMID: 30943188; PMCID: PMC6447169.
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    81. Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout. Arthritis Care Res (Hoboken). 2019 03; 71(3):427-434. Bursill D, Taylor WJ, Terkeltaub R, Kuwabara M, Merriman TR, Grainger R, Pineda C, Louthrenoo W, Edwards NL, Andrés M, Vargas-Santos AB, Roddy E, Pascart T, Lin CT, Perez-Ruiz F, Tedeschi SK, Kim SC, Harrold LR, McCarthy G, Kumar N, Chapman PT, Tausche AK, Vazquez-Mellado J, Gutierrez M, da Rocha Castelar-Pinheiro G, Richette P, Pascual E, Fisher MC, Burgos-Vargas R, Robinson PC, Singh JA, Jansen TL, Saag KG, Slot O, Uhlig T, Solomon DH, Keenan RT, Scire CA, Biernat-Kaluza E, Dehlin M, Nuki G, Schlesinger N, Janssen M, Stamp LK, Sivera F, Reginato AM, Jacobsson L, Lioté F, Ea HK, Rosenthal A, Bardin T, Choi HK, Hershfield MS, Czegley C, Choi SJ, Dalbeth N. PMID: 29799677; PMCID: PMC6252290.
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    82. Reply. Arthritis Rheumatol. 2019 03; 71(3):481-482. Choi H, Neogi T, Stamp L, Dalbeth N, Terkeltaub R. PMID: 30295436.
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    83. Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study. Arthritis Res Ther. 2019 01 07; 21(1):8. Dalbeth N, Jones G, Terkeltaub R, Khanna D, Fung M, Baumgartner S, Perez-Ruiz F. PMID: 30616614; PMCID: PMC6322285.
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    84. Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. Rheumatology (Oxford). 2019 01 01; 58(1):61-69. Terkeltaub R, Saag KG, Goldfarb DS, Baumgartner S, Schechter BM, Valiyil R, Jalal D, Pillinger M, White WB. PMID: 30124941; PMCID: PMC6293483.
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    85. New Perspectives in Rheumatology: Implications of the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities Trial and the Associated Food and Drug Administration Public Safety Alert. Arthritis Rheumatol. 2018 11; 70(11):1702-1709. Choi H, Neogi T, Stamp L, Dalbeth N, Terkeltaub R. PMID: 29869840; PMCID: PMC6203619.
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    86. Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling. Development. 2018 09 20; 145(18). Jin Y, Cong Q, Gvozdenovic-Jeremic J, Hu J, Zhang Y, Terkeltaub R, Yang Y. PMID: 30111653; PMCID: PMC6176935.
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    87. Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling. Arthritis Res Ther. 2018 09 06; 20(1):204. McWherter C, Choi YJ, Serrano RL, Mahata SK, Terkeltaub R, Liu-Bryan R. PMID: 30189890; PMCID: PMC6127987.
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    88. Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. J Biol Chem. 2018 08 03; 293(31):12259-12270. Chen LY, Lotz M, Terkeltaub R, Liu-Bryan R. PMID: 29929979; PMCID: PMC6078460.
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    89. Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition. Arthritis Rheumatol. 2018 08; 70(8):1182-1191. Abhishek A, Neogi T, Choi H, Doherty M, Rosenthal AK, Terkeltaub R. PMID: 29609209; PMCID: PMC6105380.
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    90. Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan. Arthritis Rheumatol. 2018 07; 70(7):1030-1041. Serrano RL, Chen LY, Lotz MK, Liu-Bryan R, Terkeltaub R. PMID: 29457374; PMCID: PMC6019618.
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    91. The nomenclature of the basic disease elements of gout: A content analysis of contemporary medical journals. Semin Arthritis Rheum. 2018 12; 48(3):456-461. Bursill D, Taylor WJ, Terkeltaub R, Dalbeth N. PMID: 29706241; PMCID: PMC7372969.
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    92. Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis. Arthritis Res Ther. 2017 Oct 24; 19(1):236. Zeng C, Wei J, Terkeltaub R, Yang T, Choi HK, Wang YL, Xie DX, Hunter DJ, Zhang Y, Li H, Cui Y, Li LJ, Lei GH. PMID: 29065924; PMCID: PMC5655810.
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    93. What makes gouty inflammation so variable? BMC Med. 2017 08 18; 15(1):158. Terkeltaub R. PMID: 28818081; PMCID: PMC5561591.
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    97. PPARGC1B: insight into the expression of the gouty inflammation phenotype: PPARGC1B and gouty inflammation. Rheumatology (Oxford). 2017 03 01; 56(3):323-325. Merriman T, Terkeltaub R. PMID: 28003496.
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    98. Review: Gout: A Roadmap to Approaches for Improving Global Outcomes. Arthritis Rheumatol. 2017 01; 69(1):22-34. Dalbeth N, Choi HK, Terkeltaub R. PMID: 27389665; PMCID: PMC5195886.
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    102. Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds Consensus Exercises. Arthritis Care Res (Hoboken). 2016 05; 68(5):667-72. de Lautour H, Taylor WJ, Adebajo A, Alten R, Burgos-Vargas R, Chapman P, Cimmino MA, da Rocha Castelar Pinheiro G, Day R, Harrold LR, Helliwell P, Janssen M, Kerr G, Kavanaugh A, Khanna D, Khanna PP, Lin C, Louthrenoo W, McCarthy G, Vazquez-Mellado J, Mikuls TR, Neogi T, Ogdie A, Perez-Ruiz F, Schlesinger N, Ralph Schumacher H, Scirè CA, Singh JA, Sivera F, Slot O, Stamp LK, Tausche AK, Terkeltaub R, Uhlig T, van de Laar M, White D, Yamanaka H, Zeng X, Dalbeth N. PMID: 26414176.
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    103. Racial disparities in the risk of Stevens-Johnson Syndrome and toxic epidermal necrolysis as urate-lowering drug adverse events in the United States. Semin Arthritis Rheum. 2016 10; 46(2):253-258. Lu N, Rai SK, Terkeltaub R, Kim SC, Menendez ME, Choi HK. PMID: 27217070; PMCID: PMC5035554.
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    104. Editorial: Can GPR43 Sensing of Short-Chain Fatty Acids Unchain Inflammasome-Driven Arthritis? Arthritis Rheumatol. 2015 Jun; 67(6):1419-23. Haslberger A, Terkeltaub R. PMID: 25914362; PMCID: PMC4446232.
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    105. Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol. 2015 May; 67(8):2141-53. Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R. PMID: 25940958; PMCID: PMC4519411.
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    106. Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol. 2014 Nov; 66(11):3073-82. Zhao X, Petursson F, Viollet B, Lotz M, Terkeltaub R, Liu-Bryan R. PMID: 25047750; PMCID: PMC4343036.
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    107. AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages. Ann Rheum Dis. 2016 Jan; 75(1):286-94. Wang Y, Viollet B, Terkeltaub R, Liu-Bryan R. PMID: 25362043; PMCID: PMC4417082.
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    108. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015 Jan; 11(1):35-44. Liu-Bryan R, Terkeltaub R. PMID: 25266449; PMCID: PMC4374654.
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    109. Apolipoprotein a-I at the interface of vascular inflammation and arthritis. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):474-6. Terkeltaub R. PMID: 24554604; PMCID: PMC3975075.
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    110. Treatment of acute gout: a systematic review. Semin Arthritis Rheum. 2014 Aug; 44(1):31-8. Khanna PP, Gladue HS, Singh MK, FitzGerald JD, Bae S, Prakash S, Kaldas M, Gogia M, Berrocal V, Townsend W, Terkeltaub R, Khanna D. PMID: 24650777.
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    111. Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression. Atherosclerosis. 2014 Apr; 233(2):493-502. Serrano RL, Yu W, Terkeltaub R. PMID: 24530784; PMCID: PMC4386864.
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    112. Gout: multinational gout guidelines: how do we move beyond 'déjà vu'? Nat Rev Rheumatol. 2013 Oct; 9(10):567-9. Terkeltaub R. PMID: 24045709.
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    113. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res Ther. 2013 Jul 25; 15(4):R77. Petursson F, Husa M, June R, Lotz M, Terkeltaub R, Liu-Bryan R. PMID: 23883619; PMCID: PMC3979085.
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    114. Are cherries now ripe for use as a complementary therapeutic in gout? Appraisal of the state of evidence. Evid Based Med. 2013 Dec; 18(6):230-1. Terkeltaub R. PMID: 23416419.
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    115. A delphi exercise to identify characteristic features of gout - opinions from patients and physicians, the first stage in developing new classification criteria. J Rheumatol. 2013 Apr; 40(4):498-505. Prowse RL, Dalbeth N, Kavanaugh A, Adebajo AO, Gaffo AL, Terkeltaub R, Mandell BF, Suryana BP, Goldenstein-Schainberg C, Diaz-Torne C, Khanna D, Lioté F, Mccarthy G, Kerr GS, Yamanaka H, Janssens H, Baraf HF, Chen JH, Vazquez-Mellado J, Harrold LR, Stamp LK, Van De Laar MA, Janssen M, Doherty M, Boers M, Edwards NL, Gow P, Chapman P, Khanna P, Helliwell PS, Grainger R, Schumacher HR, Neogi T, Jansen TL, Louthrenoo W, Sivera F, Taylor WJ, Alten R. PMID: 23418379.
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    116. Rilonacept in the treatment of acute gouty arthritis: a randomized, controlled clinical trial using indomethacin as the active comparator. Arthritis Res Ther. 2013 Feb 01; 15(1):R25. Terkeltaub RA, Schumacher HR, Carter JD, Baraf HS, Evans RR, Wang J, King-Davis S, Weinstein SP. PMID: 23375025; PMCID: PMC3672764.
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    117. C/EBP homologous protein drives pro-catabolic responses in chondrocytes. Arthritis Res Ther. 2013; 15(6):R218. Husa M, Petursson F, Lotz M, Terkeltaub R, Liu-Bryan R. PMID: 24351550; PMCID: PMC3978428.
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    118. Imaging joints for calcium pyrophosphate crystal deposition: a knock to the knees. Arthritis Res Ther. 2012 Dec 27; 14(6):128. Terkeltaub R. PMID: 23270654; PMCID: PMC3674586.
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    119. Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study. Arthritis Care Res (Hoboken). 2012 Oct; 64(10):1462-70. Schumacher HR, Evans RR, Saag KG, Clower J, Jennings W, Weinstein SP, Yancopoulos GD, Wang J, Terkeltaub R. PMID: 22549879.
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    120. 2012 American College of Rheumatology guidelines for management of gout. Part 2: therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken). 2012 Oct; 64(10):1447-61. Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogi T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R, American College of Rheumatology. PMID: 23024029; PMCID: PMC3662546.
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    121. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012 Oct; 64(10):1431-46. Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R, American College of Rheumatology. PMID: 23024028; PMCID: PMC3683400.
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    122. The growing array of innate inflammatory ignition switches in osteoarthritis. Arthritis Rheum. 2012 Jul; 64(7):2055-8. Liu-Bryan R, Terkeltaub R. PMID: 22488656; PMCID: PMC3711830.
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    123. Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia. PLoS One. 2012; 7(6):e39106. Dammanahalli KJ, Stevens S, Terkeltaub R. PMID: 22720042; PMCID: PMC3374784.
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    124. Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia. J Clin Rheumatol. 2012 Jun; 18(4):192-5. Gruber BL, Couto AR, Armas JB, Brown MA, Finzel K, Terkeltaub RA. PMID: 22647861; PMCID: PMC4362680.
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    125. RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity. Atherosclerosis. 2012 Jun; 222(2):417-25. Yu W, Liu-Bryan R, Stevens S, Damanahalli JK, Terkeltaub R. PMID: 22552116; PMCID: PMC3361645.
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    126. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2012 Mar; 64(3):876-84. Schumacher HR, Sundy JS, Terkeltaub R, Knapp HR, Mellis SJ, Stahl N, Yancopoulos GD, Soo Y, King-Davis S, Weinstein SP, Radin AR, 0619 Study Group. PMID: 22223180.
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    127. Are either or both hyperuricemia and xanthine oxidase directly toxic to the vasculature? A critical appraisal. Arthritis Rheum. 2012 Feb; 64(2):327-38. Neogi T, George J, Rekhraj S, Struthers AD, Choi H, Terkeltaub RA. PMID: 21953377; PMCID: PMC3265683.
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    128. Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Genet. 2012 Jan 13; 90(1):25-39. Nitschke Y, Baujat G, Botschen U, Wittkampf T, du Moulin M, Stella J, Le Merrer M, Guest G, Lambot K, Tazarourte-Pinturier MF, Chassaing N, Roche O, Feenstra I, Loechner K, Deshpande C, Garber SJ, Chikarmane R, Steinmann B, Shahinyan T, Martorell L, Davies J, Smith WE, Kahler SG, McCulloch M, Wraige E, Loidi L, Höhne W, Martin L, Hadj-Rabia S, Terkeltaub R, Rutsch F. PMID: 22209248; PMCID: PMC3257960.
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    129. Npp1 promotes atherosclerosis in ApoE knockout mice. J Cell Mol Med. 2011 Nov; 15(11):2273-83. Nitschke Y, Weissen-Plenz G, Terkeltaub R, Rutsch F. PMID: 21477221; PMCID: PMC3154990.
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    130. Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel. Circ Res. 2011 Aug 19; 109(5):578-92. Rutsch F, Nitschke Y, Terkeltaub R. PMID: 21852556; PMCID: PMC3248761.
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    131. Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors. Arthritis Rheum. 2011 Aug; 63(8):2226-37. Terkeltaub RA, Furst DE, Digiacinto JL, Kook KA, Davis MW. PMID: 21480191.
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    132. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α. Arthritis Rheum. 2011 Jul; 63(7):1928-37. Terkeltaub R, Yang B, Lotz M, Liu-Bryan R. PMID: 21400477; PMCID: PMC3128233.
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    133. Minimally important differences of the gout impact scale in a randomized controlled trial. Rheumatology (Oxford). 2011 Jul; 50(7):1331-6. Khanna D, Sarkin AJ, Khanna PP, Shieh MM, Kavanaugh AF, Terkeltaub RA, Lee SJ, Singh JA, Hirsch JD. PMID: 21372003; PMCID: PMC3307519.
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    134. Arterial calcification is driven by RAGE in Enpp1-/- mice. J Vasc Res. 2011; 48(3):227-35. Cecil DL, Terkeltaub RA. PMID: 21099228; PMCID: PMC2997448.
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    135. Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study. J Rheumatol. 2011 Jan; 38(1):111-7. Neogi T, Terkeltaub R, Ellison RC, Hunt S, Zhang Y. PMID: 20889594; PMCID: PMC3119360.
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    136. Predictors of doctor-rated and patient-rated gout severity: gout impact scales improve assessment. J Eval Clin Pract. 2010 Dec; 16(6):1244-7. Sarkin AJ, Levack AE, Shieh MM, Kavanaugh AF, Khanna D, Singh JA, Terkeltaub RA, Lee SJ, Hirsch JD. PMID: 20722884.
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    137. Cartilage cell clusters. Arthritis Rheum. 2010 Aug; 62(8):2206-18. Lotz MK, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D'Lima D. PMID: 20506158; PMCID: PMC2921934.
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    138. Chondrocyte innate immune myeloid differentiation factor 88-dependent signaling drives procatabolic effects of the endogenous Toll-like receptor 2/Toll-like receptor 4 ligands low molecular weight hyaluronan and high mobility group box chromosomal protein 1 in mice. Arthritis Rheum. 2010 Jul; 62(7):2004-12. Liu-Bryan R, Terkeltaub R. PMID: 20506365; PMCID: PMC2902571.
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    139. Shifting HIFs in osteoarthritis. Nat Med. 2010 Jun; 16(6):641-4. Husa M, Liu-Bryan R, Terkeltaub R. PMID: 20526316; PMCID: PMC2917906.
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    140. High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis Rheum. 2010 Apr; 62(4):1060-8. Terkeltaub RA, Furst DE, Bennett K, Kook KA, Crockett RS, Davis MW. PMID: 20131255.
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    141. Gout disease-specific quality of life and the association with gout characteristics. Patient Relat Outcome Meas. 2010 Mar 01; 2010:1-8. Hirsch JD, Terkeltaub R, Khanna D, Singh J, Sarkin A, Shieh M, Kavanaugh A, Lee SJ. PMID: 21686040; PMCID: PMC3113652.
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    142. Update on gout: new therapeutic strategies and options. Nat Rev Rheumatol. 2010 Jan; 6(1):30-8. Terkeltaub R. PMID: 20046204.
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    143. Inorganic pyrophosphatase induces type I collagen in osteoblasts. Bone. 2010 Jan; 46(1):81-90. Polewski MD, Johnson KA, Foster M, Millán JL, Terkeltaub R. PMID: 19733704; PMCID: PMC2818162.
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    144. The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study. Ann Rheum Dis. 2009 Oct; 68(10):1613-7. Terkeltaub R, Sundy JS, Schumacher HR, Murphy F, Bookbinder S, Biedermann S, Wu R, Mellis S, Radin A. PMID: 19635719; PMCID: PMC2732898.
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    145. Gout. Novel therapies for treatment of gout and hyperuricemia. Arthritis Res Ther. 2009; 11(4):236. Terkeltaub R. PMID: 19664185; PMCID: PMC2745774.
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    146. Gout Study Group: update on hyperuricemia and gout. Joint Bone Spine. 2009 Jul; 76(4):444-6. Terkeltaub R, Zelman D, Scavulli J, Perez-Ruiz F, Lioté F. PMID: 19559637.
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    147. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann Rheum Dis. 2009 Oct; 68(10):1602-8. Torres R, Macdonald L, Croll SD, Reinhardt J, Dore A, Stevens S, Hylton DM, Rudge JS, Liu-Bryan R, Terkeltaub RA, Yancopoulos GD, Murphy AJ. PMID: 19528034.
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    148. The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. J Immunol. 2009 Apr 15; 182(8):5024-31. Cecil DL, Appleton CT, Polewski MD, Mort JS, Schmidt AM, Bendele A, Beier F, Terkeltaub R. PMID: 19342682; PMCID: PMC2698125.
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    149. A sugar transporter regulates serum urate levels: implications for prevention and management of hyperuricemia in gout. Curr Rheumatol Rep. 2009 Apr; 11(2):83-6. Terkeltaub RA. PMID: 19296879.
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    150. A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. Curr Rheumatol Rep. 2009 Apr; 11(2):135-40. Chao J, Terkeltaub R. PMID: 19296886.
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    151. Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA. Osteoarthritis Cartilage. 2009 Aug; 17(8):1056-64. Huebner JL, Johnson KA, Kraus VB, Terkeltaub RA. PMID: 19328881; PMCID: PMC3249463.
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    152. Perceptions of disease and health-related quality of life among patients with gout. Rheumatology (Oxford). 2009 May; 48(5):582-6. Lee SJ, Hirsch JD, Terkeltaub R, Khanna D, Singh JA, Sarkin A, Kavanaugh A. PMID: 19307257; PMCID: PMC2722803.
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    153. Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study. J Rheumatol. 2009 Feb; 36(2):378-84. Neogi T, Ellison RC, Hunt S, Terkeltaub R, Felson DT, Zhang Y. PMID: 19012359; PMCID: PMC2731484.
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    154. Macrophage glucocorticoid receptors join the intercellular dialogue in atherosclerotic lesion calcification. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2096-8. Terkeltaub R. PMID: 19020314; PMCID: PMC2746738.
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    155. Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet. 2008 Dec; 1(2):133-40. Rutsch F, Böyer P, Nitschke Y, Ruf N, Lorenz-Depierieux B, Wittkampf T, Weissen-Plenz G, Fischer RJ, Mughal Z, Gregory JW, Davies JH, Loirat C, Strom TM, Schnabel D, Nürnberg P, Terkeltaub R, GACI Study Group. PMID: 20016754; PMCID: PMC2794045.
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    156. Colchicine update: 2008. Semin Arthritis Rheum. 2009 Jun; 38(6):411-9. Terkeltaub RA. PMID: 18973929.
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    157. Evaluation of an instrument assessing influence of Gout on health-related quality of life. J Rheumatol. 2008 Dec; 35(12):2406-14. Hirsch JD, Lee SJ, Terkeltaub R, Khanna D, Singh J, Sarkin A, Harvey J, Kavanaugh A. PMID: 18925685.
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    158. Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes. J Immunol. 2008 Jun 15; 180(12):8378-85. Cecil DL, Terkeltaub R. PMID: 18523305; PMCID: PMC2577366.
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    159. Factor XIIIA mobilizes transglutaminase 2 to induce chondrocyte hypertrophic differentiation. J Cell Sci. 2008 Jul 01; 121(Pt 13):2256-64. Johnson KA, Rose DM, Terkeltaub RA. PMID: 18544639; PMCID: PMC2615675.
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    160. Enzyme replacement therapy for murine hypophosphatasia. J Bone Miner Res. 2008 Jun; 23(6):777-87. Millán JL, Narisawa S, Lemire I, Loisel TP, Boileau G, Leonard P, Gramatikova S, Terkeltaub R, Camacho NP, McKee MD, Crine P, Whyte MP. PMID: 18086009; PMCID: PMC2652241.
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    161. Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells. Circ Res. 2008 Mar 14; 102(5):529-37. Johnson KA, Polewski M, Terkeltaub RA. PMID: 18202319; PMCID: PMC2652242.
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    162. Vanin-1 pantetheinase drives increased chondrogenic potential of mesenchymal precursors in ank/ank mice. Am J Pathol. 2008 Feb; 172(2):440-53. Johnson KA, Yao W, Lane NE, Naquet P, Terkeltaub RA. PMID: 18187567; PMCID: PMC2312367.
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    163. Learning how and when to employ uricase as bridge therapy in refractory gout. J Rheumatol. 2007 Oct; 34(10):1955-8. Terkeltaub R. PMID: 17924606.
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    164. Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2. J Bone Miner Res. 2007 Sep; 22(9):1397-407. Hough TA, Polewski M, Johnson K, Cheeseman M, Nolan PM, Vizor L, Rastan S, Boyde A, Pritzker K, Hunter AJ, Fisher EM, Terkeltaub R, Brown SD. PMID: 17539739.
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    165. Last call for alcohol in gout? Curr Rheumatol Rep. 2007 Jun; 9(3):229-30. Hennigan S, Terkeltaub R. PMID: 17531176.
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    166. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 2007 Apr; 132(4):1515-26. Strnad P, Harada M, Siegel M, Terkeltaub RA, Graham RM, Khosla C, Omary MB. PMID: 17408647.
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    167. Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis. Osteoarthritis Cartilage. 2007 May; 15(5):559-65. Mitsuyama H, Healey RM, Terkeltaub RA, Coutts RD, Amiel D. PMID: 17276093; PMCID: PMC2707182.
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    168. Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J Immunol. 2006 Nov 01; 177(9):6370-8. Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R. PMID: 17056568.
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    169. Lower prevalence of chondrocalcinosis in Chinese subjects in Beijing than in white subjects in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum. 2006 Nov; 54(11):3508-12. Zhang Y, Terkeltaub R, Nevitt M, Xu L, Neogi T, Aliabadi P, Niu J, Felson DT. PMID: 17075853.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    170. Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils. Arthritis Rheum. 2006 Oct; 54(10):3363-71. Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R. PMID: 17009310.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    171. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res. 2006 Sep; 21(9):1377-86. Harmey D, Johnson KA, Zelken J, Camacho NP, Hoylaerts MF, Noda M, Terkeltaub R, Millán JL. PMID: 16939396.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    172. Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification. Purinergic Signal. 2006 Jun; 2(2):371-7. Terkeltaub R. PMID: 18404477; PMCID: PMC2254483.
      View in: PubMed   Mentions: 42     Fields:    
    173. New developments in clinically relevant mechanisms and treatment of hyperuricemia. Curr Rheumatol Rep. 2006 Jun; 8(3):224-30. Lee SJ, Terkeltaub RA. PMID: 16901081.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    174. Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics. Arthritis Res Ther. 2006; 8 Suppl 1:S4. Terkeltaub R, Bushinsky DA, Becker MA. PMID: 16820043; PMCID: PMC3226109.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    175. The inflammatory process of gout and its treatment. Arthritis Res Ther. 2006; 8 Suppl 1:S3. Cronstein BN, Terkeltaub R. PMID: 16820042; PMCID: PMC3226108.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    176. Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol. 2006 Apr; 168(4):1385-95. Boisvert WA, Rose DM, Johnson KA, Fuentes ME, Lira SA, Curtiss LK, Terkeltaub RA. PMID: 16565511; PMCID: PMC1606562.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    177. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis Rheum. 2006 Apr; 54(4):1255-61. Neogi T, Booth SL, Zhang YQ, Jacques PF, Terkeltaub R, Aliabadi P, Felson DT. PMID: 16572460.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    178. Recent developments in diet and gout. Curr Opin Rheumatol. 2006 Mar; 18(2):193-8. Lee SJ, Terkeltaub RA, Kavanaugh A. PMID: 16462528.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    179. Evil humors take their toll as innate immunity makes gouty joints TREM-ble. Arthritis Rheum. 2006 Feb; 54(2):383-6. Liu-Bryan R, Terkeltaub R. PMID: 16447213.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    180. Hyperuricemia treatment: is creatinine clearance a safer allopurinol dosing meter than plasma creatinine levels? Nat Clin Pract Rheumatol. 2006 Feb; 2(2):68-9. Terkeltaub R. PMID: 16932657.
      View in: PubMed   Mentions: 1     Fields:    
    181. Gout in 2006: the perfect storm. Bull NYU Hosp Jt Dis. 2006; 64(1-2):82-6. Terkeltaub R. PMID: 17121496.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    182. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol. 2005 Dec 15; 175(12):8296-302. Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R. PMID: 16339570.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    183. Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 2005 Sep; 52(9):2936-46. Liu-Bryan R, Scott P, Sydlaske A, Rose DM, Terkeltaub R. PMID: 16142712.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    184. Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. Am J Pathol. 2005 Jun; 166(6):1711-20. Anderson HC, Harmey D, Camacho NP, Garimella R, Sipe JB, Tague S, Bi X, Johnson K, Terkeltaub R, Millán JL. PMID: 15920156; PMCID: PMC1602415.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    185. What do epidemiologic studies tell us about hyperuricemia and cardiovascular disease and death? Curr Rheumatol Rep. 2005 Jun; 7(3):211-2. Wu CW, Terkeltaub R. PMID: 15918997.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    186. Calcium-containing crystals and osteoarthritis: implications for the clinician. Curr Rheumatol Rep. 2005 Jun; 7(3):213-9. Wu CW, Terkeltaub R, Kalunian KC. PMID: 15918998.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    187. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J Immunol. 2005 Apr 15; 174(8):5016-23. Liu-Bryan R, Pritzker K, Firestein GS, Terkeltaub R. PMID: 15814732.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    188. Association of sporadic chondrocalcinosis with a -4-basepair G-to-A transition in the 5'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess generation of extracellular inorganic pyrophosphate. Arthritis Rheum. 2005 Apr; 52(4):1110-7. Zhang Y, Johnson K, Russell RG, Wordsworth BP, Carr AJ, Terkeltaub RA, Brown MA. PMID: 15818664.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    189. Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification. Joint Bone Spine. 2005 Mar; 72(2):110-8. Rutsch F, Terkeltaub R. PMID: 15797489.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    190. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. J Biol Chem. 2005 Apr 15; 280(15):15004-12. Johnson KA, Terkeltaub RA. PMID: 15691824.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    191. Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance. Diabetes. 2005 Feb; 54(2):367-72. Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID. PMID: 15677494.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    192. The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with generalized arterial calcification of infancy (GACI). Hum Mutat. 2005 Jan; 25(1):98. Ruf N, Uhlenberg B, Terkeltaub R, Nürnberg P, Rutsch F. PMID: 15605415.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    193. Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage. Front Biosci. 2005 Jan 01; 10:988-97. Johnson K, Terkeltaub R. PMID: 15569637.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    194. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Arthritis Rheum. 2005 Jan; 52(1):144-54. Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R. PMID: 15641067.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    195. Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- mice. Arterioscler Thromb Vasc Biol. 2005 Apr; 25(4):686-91. Johnson K, Polewski M, van Etten D, Terkeltaub R. PMID: 15625282.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    196. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Arthritis Rheum. 2004 Aug; 50(8):2633-9. Tramontini N, Huber C, Liu-Bryan R, Terkeltaub RA, Kilgore KS. PMID: 15334478.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    197. Gout: on the brink of novel therapeutic options for an ancient disease. Arthritis Rheum. 2004 Aug; 50(8):2400-14. Bieber JD, Terkeltaub RA. PMID: 15334451.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    198. The role of hypertension in cyclosporine-induced hyperuricemia. Curr Rheumatol Rep. 2004 Jun; 6(3):215-6. Bieber J, Terkeltaub R. PMID: 15134600.
      View in: PubMed   Mentions:    Fields:    
    199. Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum. 2004 Apr; 50(4):1216-25. Johnson K, Svensson CI, Etten DV, Ghosh SS, Murphy AN, Powell HC, Terkeltaub R. PMID: 15077304.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    200. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol. 2004 Apr; 164(4):1199-209. Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millán JL. PMID: 15039209; PMCID: PMC1615351.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    201. Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum. 2004 Jan; 50(1):247-58. Liu R, Lioté F, Rose DM, Merz D, Terkeltaub R. PMID: 14730623.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    202. Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1. Am J Physiol Cell Physiol. 2004 May; 286(5):C1177-87. Vaingankar SM, Fitzpatrick TA, Johnson K, Goding JW, Maurice M, Terkeltaub R. PMID: 15075217.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    203. IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor. J Immunol. 2003 Dec 15; 171(12):6714-22. Schraufstatter IU, Trieu K, Zhao M, Rose DM, Terkeltaub RA, Burger M. PMID: 14662875.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    204. Questions & answers. What's the difference between gout and pseudogout? Health News. 2003 Dec; 9(12):16. Terkeltaub RA. PMID: 14679973.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    205. Clinical practice. Gout. N Engl J Med. 2003 Oct 23; 349(17):1647-55. Terkeltaub RA. PMID: 14573737.
      View in: PubMed   Mentions: 139     Fields:    Translation:Humans
    206. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol. 2003 Oct 15; 171(8):4406-15. Merz D, Liu R, Johnson K, Terkeltaub R. PMID: 14530367.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    207. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet. 2003 Aug; 34(4):379-81. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Höhne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nürnberg P. PMID: 12881724.
      View in: PubMed   Mentions: 278     Fields:    Translation:Humans
    208. Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res. 2003 Jun; 18(6):994-1004. Johnson K, Goding J, Van Etten D, Sali A, Hu SI, Farley D, Krug H, Hessle L, Millán JL, Terkeltaub R. PMID: 12817751.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    209. Calcium pyrophosphate dihydrate and hydroxyapatite crystal deposition in the joint: new developments relevant to the clinician. Curr Rheumatol Rep. 2003 Jun; 5(3):235-43. Pay S, Terkeltaub R. PMID: 12744817.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    210. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May; 48(5):1302-14. Johnson K, Farley D, Hu SI, Terkeltaub R. PMID: 12746903.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    211. Parallels between arterial and cartilage calcification: what understanding artery calcification can teach us about chondrocalcinosis. Curr Opin Rheumatol. 2003 May; 15(3):302-10. Rutsch F, Terkeltaub R. PMID: 12707585.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    212. Distinct transglutaminase 2-independent and transglutaminase 2-dependent pathways mediate articular chondrocyte hypertrophy. J Biol Chem. 2003 May 23; 278(21):18824-32. Johnson KA, van Etten D, Nanda N, Graham RM, Terkeltaub RA. PMID: 12606540.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    213. Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor. Nat Med. 2002 Sep; 8(9):995-1003. Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA. PMID: 12185361.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    214. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A. 2002 Jul 09; 99(14):9445-9. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL. PMID: 12082181; PMCID: PMC123160.
      View in: PubMed   Mentions: 291     Fields:    Translation:AnimalsCells
    215. Pseudogout, hypomagnesemia, and liver transplantation. Curr Rheumatol Rep. 2002 Jun; 4(3):243-4. Terkeltaub R. PMID: 12010609.
      View in: PubMed   Mentions:    Fields:    
    216. What does cartilage calcification tell us about osteoarthritis? J Rheumatol. 2002 Mar; 29(3):411-5. Terkeltaub RA. PMID: 11908551.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    217. Invited review: the mitochondrion in osteoarthritis. Mitochondrion. 2002 Feb; 1(4):301-19. Terkeltaub R, Johnson K, Murphy A, Ghosh S. PMID: 16120285.
      View in: PubMed   Mentions: 49     Fields:    
    218. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol. 2001 Jul; 281(1):C1-C11. Terkeltaub RA. PMID: 11401820.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    219. Interleukin-8 and its receptor CXCR2 in atherosclerosis. Immunol Res. 2000; 21(2-3):129-37. Boisvert WA, Curtiss LK, Terkeltaub RA. PMID: 10852110.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    220. Clinical trials review: crystal deposition diseases. Curr Rheumatol Rep. 1999 Dec; 1(2):97-100. Terkeltaub RA. PMID: 11123021.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    221. New developments in the pathogenesis of articular cartilage calcification. Curr Rheumatol Rep. 1999 Dec; 1(2):121-7. Karpouzas GA, Terkeltaub RA. PMID: 11123025.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    222. Noninvasive evaluation of adult onset myopathy from carnitine palmitoyl transferase II deficiency using proton magnetic resonance spectroscopy. J Rheumatol. 1999 Aug; 26(8):1757-63. Videen JS, Haseler LJ, Karpinski NC, Terkeltaub RA. PMID: 10451074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    223. Chemokines and atherosclerosis. Curr Opin Lipidol. 1998 Oct; 9(5):397-405. Terkeltaub R, Boisvert WA, Curtiss LK. PMID: 9812193.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    224. Bone morphogenetic proteins and bFGF exert opposing regulatory effects on PTHrP expression and inorganic pyrophosphate elaboration in immortalized murine endochondral hypertrophic chondrocytes (MCT cells). J Bone Miner Res. 1998 Jun; 13(6):931-41. Terkeltaub RA, Johnson K, Rohnow D, Goomer R, Burton D, Deftos LJ. PMID: 9626624.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    225. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest. 1998 Jan 15; 101(2):353-63. Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA. PMID: 9435307; PMCID: PMC508574.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    226. Hypercalcemia and systemic lupus erythematosus. Arthritis Rheum. 1996 Dec; 39(12):2066-9. Deftos LJ, Burton DW, Baird SM, Terkeltaub RA. PMID: 8961913.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    227. Expression of the nucleoside triphosphate pyrophosphohydrolase PC-1 is induced by basic fibroblast growth factor (bFGF) and modulated by activation of the protein kinase A and C pathways in osteoblast-like osteosarcoma cells. J Bone Miner Res. 1996 Feb; 11(2):183-92. Solan JL, Deftos LJ, Goding JW, Terkeltaub RA. PMID: 8822342.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    228. Gout: questions that still need to be answered. Ann Rheum Dis. 1995 Feb; 54(2):79-81. Terkeltaub RA. PMID: 7702409; PMCID: PMC1005523.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    229. Oxidized LDL enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes. Arterioscler Thromb. 1994 May; 14(5):790-7. Brand K, Banka CL, Mackman N, Terkeltaub RA, Fan ST, Curtiss LK. PMID: 8172855.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    230. Gout and mechanisms of crystal-induced inflammation. Curr Opin Rheumatol. 1993 Jul; 5(4):510-6. Terkeltaub RA. PMID: 8357747.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    231. What stops a gouty attack? J Rheumatol. 1992 Jan; 19(1):8-10. Terkeltaub RA. PMID: 1556704.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    232. Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo. J Clin Invest. 1991 Jan; 87(1):20-6. Terkeltaub RA, Dyer CA, Martin J, Curtiss LK. PMID: 1985096; PMCID: PMC294981.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    233. Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways. J Immunol. 1990 Apr 01; 144(7):2719-24. Terkeltaub RA, Sklar LA, Mueller H. PMID: 2108211.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    234. Acute monoarthritis associated with intracellular positively birefringent Maltese cross appearing spherules. J Rheumatol. 1989 Mar; 16(3):394-6. Gardner GC, Terkeltaub RA. PMID: 2542545.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    235. The inflammatory reaction to crystals. Rheum Dis Clin North Am. 1988 Aug; 14(2):353-64. Terkeltaub RA, Ginsberg MH. PMID: 3051154.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
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