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Marsida Kallupi

Title(s)Assistant Adjunct Professor, Psychiatry
SchoolHealth Sciences
Phone858-246-5537
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    Collapse Biography 
    Collapse Education and Training
    The Scripps Research Institute, La JollaResearch Associate2019Neuroscience
    University of Camerino, ItalyPhD2010Pharmaceutical Science
    National Pharmacist Qualification , ItalyPharmD2007Pharmacy
    University of Camerino, ItalyM.S. 2006Pharmacy
    Collapse Awards and Honors
    University of Camerino, Italy2000  - 2005 ERSU Fellowship (5-year scholarship for tuition and housing expenses)
    International School of Advanced Studies 2006  - 2009PhD Fellowship
    National Institute on Alcohol Abuse and Alcoholism 2010Best Poster Presentation
    ERAB: The European Foundation for Alcohol Research2014Travel Award
    NIDA2018Travel Award
    Larry Parsons (TSRI/ARC)2018Travel Award

    Collapse Research 
    Collapse Research Activities and Funding
    Use of Next-Gen Sequencing to Identify Genetic Variants that Influence compulsive Oxycodone Intake in Outbred Rats
    NIH/NIDA U01DA044451Apr 1, 2018 - Jan 31, 2023
    Role: Co-Investigator
    Neurobehavioral effects of nicotine e-cig self-administration in rats
    TRDRP 27IR-0047Apr 1, 2018 - Mar 31, 2021
    Role: Co-Investigator
    Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake in Rats
    NIH/NIDA U01DA043799Apr 1, 2017 - Feb 28, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kallupi M, de Guglielmo G, Larrosa E, George O. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. Eur Neuropsychopharmacol. 2019 Nov; 29(11):1227-1234. PMID: 31462388.
      View in: PubMed
    2. Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav. 2019 07; 18(6):e12577. PMID: 31012252.
      View in: PubMed
    3. de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019 03 18; 10(1):1238. PMID: 30886240.
      View in: PubMed
    4. Kallupi M, Xue S, Zhou B, Janda KD, George O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Sci Adv. 2018 10; 4(10):eaat4751. PMID: 30345354.
      View in: PubMed
    5. Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Sci Rep. 2018 09 17; 8(1):13893. PMID: 30224774.
      View in: PubMed
    6. Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. eNeuro. 2018 May-Jun; 5(3). PMID: 29971251.
      View in: PubMed
    7. Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. An enzymatic advance in nicotine cessation therapy. Chem Commun (Camb). 2018 Feb 13; 54(14):1686-1689. PMID: 29308799.
      View in: PubMed
    8. Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology (Berl). 2018 04; 235(4):1131-1140. PMID: 29354872.
      View in: PubMed
    9. Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology. 2018 04; 43(5):1010-1020. PMID: 29052613.
      View in: PubMed
    10. Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res. 2017 Nov; 41(11):1886-1895. PMID: 28833238.
      View in: PubMed
    11. Kallupi M, George O. Nicotine Vapor Method to Induce Nicotine Dependence in Rodents. Curr Protoc Neurosci. 2017 Jul 05; 80:8.41.1-8.41.10. PMID: 28678400.
      View in: PubMed
    12. Kallupi M, Shen Q, de Guglielmo G, Yasuda D, Journigan VB, Zaveri NT, Ciccocioppo R. Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption. Addict Biol. 2018 03; 23(2):585-595. PMID: 28635181.
      View in: PubMed
    13. de Guglielmo G, Kallupi M, Cole MD, George O. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology (Berl). 2017 Jul; 234(13):2009-2018. PMID: 28342089.
      View in: PubMed
    14. Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology. 2017 Aug; 42(9):1850-1859. PMID: 27917870.
      View in: PubMed
    15. de Guglielmo G, Kallupi M, Scuppa G, Demopulos G, Gaitanaris G, Ciccocioppo R. Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents. Psychopharmacology (Berl). 2017 Jan; 234(2):223-234. PMID: 27714428.
      View in: PubMed
    16. Kallupi M, Scuppa G, de Guglielmo G, Calò G, Weiss F, Statnick MA, Rorick-Kehn LM, Ciccocioppo R. Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction. Neuropsychopharmacology. 2017 02; 42(3):695-706. PMID: 27562376.
      View in: PubMed
    17. Cannella N, Kallupi M, Li HW, Stopponi S, Cifani C, Ciccocioppo R, Ubaldi M. Neuropeptide S differently modulates alcohol-related behaviors in alcohol-preferring and non-preferring rats. Psychopharmacology (Berl). 2016 Aug; 233(15-16):2915-24. PMID: 27235017.
      View in: PubMed
    18. Ubaldi M, Giordano A, Severi I, Li H, Kallupi M, de Guglielmo G, Ruggeri B, Stopponi S, Ciccocioppo R, Cannella N. Activation of Hypocretin-1/Orexin-A Neurons Projecting to the Bed Nucleus of the Stria Terminalis and Paraventricular Nucleus Is Critical for Reinstatement of Alcohol Seeking by Neuropeptide S. Biol Psychiatry. 2016 Mar 15; 79(6):452-62. PMID: 26055195.
      View in: PubMed
    19. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PPARc activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):1052. PMID: 25668637.
      View in: PubMed
    20. de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R. Analgesic tolerance to morphine is regulated by PPAR?. Br J Pharmacol. 2014 Dec; 171(23):5407-16. PMID: 25048682.
      View in: PubMed
    21. de Guglielmo G, Melis M, De Luca MA, Kallupi M, Li HW, Niswender K, Giordano A, Senzacqua M, Somaini L, Cippitelli A, Gaitanaris G, Demopulos G, Damadzic R, Tapocik J, Heilig M, Ciccocioppo R. PPAR? activation attenuates opioid consumption and modulates mesolimbic dopamine transmission. Neuropsychopharmacology. 2015 Mar; 40(4):927-37. PMID: 25311134.
      View in: PubMed
    22. Kallupi M, Oleata CS, Luu G, Teshima K, Ciccocioppo R, Roberto M. MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala. Front Integr Neurosci. 2014; 8:18. PMID: 24600360.
      View in: PubMed
    23. Ciccocioppo R, de Guglielmo G, Hansson AC, Ubaldi M, Kallupi M, Cruz MT, Oleata CS, Heilig M, Roberto M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors. J Neurosci. 2014 Jan 08; 34(2):363-72. PMID: 24403138.
      View in: PubMed
    24. Kallupi M, Varodayan FP, Oleata CS, Correia D, Luu G, Roberto M. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 2014 Apr; 39(5):1081-92. PMID: 24169802.
      View in: PubMed
    25. Kallupi M, Wee S, Edwards S, Whitfield TW, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biol Psychiatry. 2013 Oct 01; 74(7):520-8. PMID: 23751206.
      View in: PubMed
    26. Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addict Biol. 2014 Sep; 19(5):755-7. PMID: 23639035.
      View in: PubMed
    27. Stopponi S, de Guglielmo G, Somaini L, Cippitelli A, Cannella N, Kallupi M, Ubaldi M, Heilig M, Demopulos G, Gaitanaris G, Ciccocioppo R. Activation of PPAR? by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcohol Clin Exp Res. 2013 Aug; 37(8):1351-60. PMID: 23550625.
      View in: PubMed
    28. Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 2013 Apr; 67:337-48. PMID: 23220399.
      View in: PubMed
    29. Kallupi M, de Guglielmo G, Cannella N, Li HW, Caló G, Guerrini R, Ubaldi M, Renger JJ, Uebele VN, Ciccocioppo R. Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat. Psychopharmacology (Berl). 2013 Mar; 226(2):347-55. PMID: 23149909.
      View in: PubMed
    30. Cannella N, Kallupi M, Ruggeri B, Ciccocioppo R, Ubaldi M. The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission. Prog Neurobiol. 2013 Jan; 100:48-59. PMID: 23041581.
      View in: PubMed
    31. de Guglielmo G, Cippitelli A, Somaini L, Gerra G, Li H, Stopponi S, Ubaldi M, Kallupi M, Ciccocioppo R. Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat. Addict Biol. 2013 Jul; 18(4):644-53. PMID: 22734646.
      View in: PubMed
    32. Cruz MT, Herman MA, Kallupi M, Roberto M. Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. Biol Psychiatry. 2012 Apr 15; 71(8):666-76. PMID: 22153590.
      View in: PubMed
    33. Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodrìguez de Fonseca F, Piomelli D, Ciccocioppo R. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. PLoS One. 2011; 6(11):e28142. PMID: 22140525.
      View in: PubMed
    34. Stopponi S, Somaini L, Cippitelli A, de Guglielmo G, Kallupi M, Cannella N, Gerra G, Massi M, Ciccocioppo R. Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. Psychopharmacology (Berl). 2012 Mar; 220(1):87-96. PMID: 21887495.
      View in: PubMed
    35. Stopponi S, Somaini L, Cippitelli A, Cannella N, Braconi S, Kallupi M, Ruggeri B, Heilig M, Demopulos G, Gaitanaris G, Massi M, Ciccocioppo R. Activation of nuclear PPAR? receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking. Biol Psychiatry. 2011 Apr 01; 69(7):642-9. PMID: 21276964.
      View in: PubMed
    36. Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19567-72. PMID: 20974945.
      View in: PubMed
    37. Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M. Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov; 43(7):491-8. PMID: 19913192.
      View in: PubMed
    38. Ruggeri B, Braconi S, Cannella N, Kallupi M, Soverchia L, Ciccocioppo R, Ubaldi M. Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats. Alcohol Clin Exp Res. 2010 Jan; 34(1):90-7. PMID: 19860802.
      View in: PubMed
    39. Fedeli A, Braconi S, Economidou D, Cannella N, Kallupi M, Guerrini R, Calò G, Cifani C, Massi M, Ciccocioppo R. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S. Eur J Neurosci. 2009 Oct; 30(8):1594-602. PMID: 19821837.
      View in: PubMed
    40. Cannella N, Economidou D, Kallupi M, Stopponi S, Heilig M, Massi M, Ciccocioppo R. Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system. Neuropsychopharmacology. 2009 Aug; 34(9):2125-34. PMID: 19322167.
      View in: PubMed