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James Golden

TitleTeacher
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0116
La Jolla CA 92093
Phone858-246-0643
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
    NIH/NIGMS R01GM118815Jan 12, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Regulation of Cyanobacterial Multicellular Development
    NIH/NIGMS R01GM036890Aug 1, 1986 - Nov 30, 2008
    Role: Principal Investigator
    TRANSCRIPTIONAL PROGRAM OF HETEROCYST DEVELOPMENT
    NIH/NIGMS F32GM009733Oct 1, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Taton A, Ma AT, Ota M, Golden SS, Golden J. NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria. ACS Synth Biol. 2017 12 15; 6(12):2175-2182. PMID: 28803467.
      View in: PubMed
    2. Kim YS, Kim IS, Boyd JS, Taton A, Golden J, Yoon HS. Enhanced biomass and oxidative stress tolerance of Synechococcus elongatus PCC 7942 overexpressing the DHAR gene from Brassica juncea. Biotechnol Lett. 2017 Oct; 39(10):1499-1507. PMID: 28667417.
      View in: PubMed
    3. Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden J, Allen EE, Moore BS. Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol. 2017 05; 13(5):537-543. PMID: 28319100.
      View in: PubMed
    4. Chen Y, Taton A, Go M, London RE, Pieper LM, Golden SS, Golden J. Self-replicating shuttle vectors based on pANS, a small endogenous plasmid of the unicellular cyanobacterium Synechococcus elongatus PCC 7942. Microbiology. 2016 12; 162(12):2029-2041. PMID: 27902432.
      View in: PubMed
    5. Flaherty BL, Johnson DB, Golden J. Deep sequencing of HetR-bound DNA reveals novel HetR targets in Anabaena sp. strain PCC7120. BMC Microbiol. 2014 Oct 03; 14:255. PMID: 25278209; PMCID: PMC4192349.
    6. Ma AT, Schmidt CM, Golden J. Regulation of gene expression in diverse cyanobacterial species by using theophylline-responsive riboswitches. Appl Environ Microbiol. 2014 Nov; 80(21):6704-13. PMID: 25149516; PMCID: PMC4249034.
    7. Taton A, Unglaub F, Wright NE, Zeng WY, Paz-Yepes J, Brahamsha B, Palenik B, Peterson TC, Haerizadeh F, Golden SS, Golden J. Broad-host-range vector system for synthetic biology and biotechnology in cyanobacteria. Nucleic Acids Res. 2014; 42(17):e136. PMID: 25074377; PMCID: PMC4176158.
    8. Taton A, Lis E, Adin DM, Dong G, Cookson S, Kay SA, Golden SS, Golden J. Gene transfer in Leptolyngbya sp. strain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. PMID: 22292073.
      View in: PubMed
    9. Flaherty BL, Van Nieuwerburgh F, Head SR, Golden J. Directional RNA deep sequencing sheds new light on the transcriptional response of Anabaena sp. strain PCC 7120 to combined-nitrogen deprivation. BMC Genomics. 2011 Jun 28; 12:332. PMID: 21711558; PMCID: PMC3141674.
    10. Saha SK, Golden J. Overexpression of pknE blocks heterocyst development in Anabaena sp. strain PCC 7120. J Bacteriol. 2011 May; 193(10):2619-29. PMID: 21421755; PMCID: PMC3133150.
    11. Mella-Herrera RA, Neunuebel MR, Kumar K, Saha SK, Golden J. The sigE gene is required for normal expression of heterocyst-specific genes in Anabaena sp. strain PCC 7120. J Bacteriol. 2011 Apr; 193(8):1823-32. PMID: 21317330; PMCID: PMC3133031.
    12. Mella-Herrera RA, Neunuebel MR, Golden J. Anabaena sp. strain PCC 7120 conR contains a LytR-CpsA-Psr domain, is developmentally regulated, and is essential for diazotrophic growth and heterocyst morphogenesis. Microbiology. 2011 Mar; 157(Pt 3):617-26. PMID: 21088107.
      View in: PubMed
    13. Kumar K, Mella-Herrera RA, Golden J. Cyanobacterial heterocysts. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a000315. PMID: 20452939; PMCID: PMC2845205.
    14. Neunuebel MR, Golden J. The Anabaena sp. strain PCC 7120 gene all2874 encodes a diguanylate cyclase and is required for normal heterocyst development under high-light growth conditions. J Bacteriol. 2008 Oct; 190(20):6829-36. PMID: 18723619; PMCID: PMC2566204.
    15. Aldea MR, Mella-Herrera RA, Golden J. Sigma factor genes sigC, sigE, and sigG are upregulated in heterocysts of the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol. 2007 Nov; 189(22):8392-6. PMID: 17873052; PMCID: PMC2168693.
    16. Wu X, Lee DW, Mella RA, Golden J. The Anabaena sp. strain PCC 7120 asr1734 gene encodes a negative regulator of heterocyst development. Mol Microbiol. 2007 May; 64(3):782-94. PMID: 17462023.
      View in: PubMed
    17. Carrasco CD, Holliday SD, Hansel A, Lindblad P, Golden J. Heterocyst-specific excision of the Anabaena sp. strain PCC 7120 hupL element requires xisC. J Bacteriol. 2005 Sep; 187(17):6031-8. PMID: 16109944; PMCID: PMC1196164.
    18. Liu T, Golden J, Giedroc DP. A zinc(II)/lead(II)/cadmium(II)-inducible operon from the Cyanobacterium anabaena is regulated by AztR, an alpha3N ArsR/SmtB metalloregulator. Biochemistry. 2005 Jun 21; 44(24):8673-83. PMID: 15952774.
      View in: PubMed
    19. Khudyakov IY, Golden J. Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16040-5. PMID: 15520378; PMCID: PMC528747.
    20. Wu X, Liu D, Lee MH, Golden J. patS minigenes inhibit heterocyst development of Anabaena sp. strain PCC 7120. J Bacteriol. 2004 Oct; 186(19):6422-9. PMID: 15375122; PMCID: PMC516582.
    21. Yoon HS, Lee MH, Xiong J, Golden J. Anabaena sp. strain PCC 7120 hetY gene influences heterocyst development. J Bacteriol. 2003 Dec; 185(23):6995-7000. PMID: 14617665; PMCID: PMC262716.
    22. Golden J, Yoon HS. Heterocyst development in Anabaena. Curr Opin Microbiol. 2003 Dec; 6(6):557-63. PMID: 14662350.
      View in: PubMed
    23. Lee MH, Scherer M, Rigali S, Golden J. PlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120. J Bacteriol. 2003 Aug; 185(15):4315-25. PMID: 12867439; PMCID: PMC165748.
    24. Liu D, Golden J. hetL overexpression stimulates heterocyst formation in Anabaena sp. strain PCC 7120. J Bacteriol. 2002 Dec; 184(24):6873-81. PMID: 12446638; PMCID: PMC135482.
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