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Dionicio Siegel

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0756
La Jolla CA 92093
Phone8/8-22--3666
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    Collapse Biography 
    Collapse Awards and Honors
    2012  - 2017National Science Foundation CAREER Award
    2013Aldrich Lecturer, Yale University
    2011College of Natural Sciences Outreach Excellence Award, The University of Texas at Austin
    2010The University of Texas System Regents’ Outstanding Teaching Award
    2005  - 2007Congressionally Directed Medical Research Program Fellow, Memorial Sloan-Kettering Cancer Center
    1998Upjohn-Pharmacia Fellow, California Institute of Technology
    1997  - 1998Institute Fellowship, California Institute of Technology

    Collapse Overview 

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of Eupalinilide E and UM171, alone and in combination on cytokine stimulated ex-vivo expansion of human cord blood hematopoietic stem cells. Blood Cells Mol Dis. 2020 09; 84:102457. Zhang J, Huang X, Guo B, Cooper S, Capitano ML, Johnson TC, Siegel DR, Broxmeyer HE. PMID: 32604056.
      View in: PubMed   Mentions:    Fields:    
    2. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nat Commun. 2020 04 14; 11(1):1780. LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, Huang J, Williams RM, Zou BY, Cheung AL, Kumar P, Egan TJ, Lee MCS, Siegel D, Cowman AF, Fidock DA, Winzeler EA. PMID: 32286267.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Total Synthesis of Micrococcin P1 through Scalable Thiazole Forming Reactions of Cysteine Derivatives and Nitriles. Org Lett. 2020 Mar 20; 22(6):2365-2370. Christy MP, Johnson T, McNerlin CD, Woodard J, Nelson AT, Lim B, Hamilton TL, Freiberg KM, Siegel D. PMID: 32134277.
      View in: PubMed   Mentions:    Fields:    
    4. Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    5. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 2019 10 01; 129(10):4138-4150. Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PMID: 31449056.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. Nat Microbiol. 2019 12; 4(12):2082-2089. Zaramela LS, Martino C, Alisson-Silva F, Rees SD, Diaz SL, Chuzel L, Ganatra MB, Taron CH, Secrest P, Zuñiga C, Huang J, Siegel D, Chang G, Varki A, Zengler K. PMID: 31548686.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org Lett. 2019 10 04; 21(19):8080-8084. Wang H, Kolar MJ, Chang T, Rizo J, Konduri S, McNerlin C, Saghatelian A, Siegel D. PMID: 31545060.
      View in: PubMed   Mentions:    Fields:    
    8. PAHSAs attenuate immune responses and promote ß cell survival in autoimmune diabetic mice. J Clin Invest. 2019 08 05; 129(9):3717-3731. Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PMID: 31380811.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals. J Biol Chem. 2019 07 05; 294(27):10698-10707. Kolar MJ, Konduri S, Chang T, Wang H, McNerlin C, Ohlsson L, Härröd M, Siegel D, Saghatelian A. PMID: 31152059.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation. J Am Chem Soc. 2019 06 05; 141(22):8798-8806. Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A. PMID: 31056915.
      View in: PubMed   Mentions: 3     Fields:    
    11. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. J Antibiot (Tokyo). 2019 06; 72(6):498-506. Wang H, Chang T, Konduri S, Huang J, Saghatelian A, Siegel D. PMID: 30988370.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 02 14; 62(3):1609-1625. Perez C, Barkley-Levenson AM, Dick BL, Glatt PF, Martinez Y, Siegel D, Momper JD, Palmer AA, Cohen SM. PMID: 30628789.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science. 2018 12 07; 362(6419). Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA. PMID: 30523084.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem. 2018 04 17; 90(8):5358-5365. Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. PMID: 29578702.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri. Front Microbiol. 2018; 9:414. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. PMID: 29559968.
      View in: PubMed   Mentions:
    16. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. PMID: 29414687.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    17. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science. 2018 01 12; 359(6372):191-199. Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, Arriaga I, Bopp S, Corey VC, Gnädig NF, Coburn-Flynn O, Reimer C, Gupta P, Murithi JM, Moura PA, Fuchs O, Sasaki E, Kim SW, Teng CH, Wang LT, Akidil A, Adjalley S, Willis PA, Siegel D, Tanaseichuk O, Zhong Y, Zhou Y, Llinás M, Ottilie S, Gamo FJ, Lee MCS, Goldberg DE, Fidock DA, Wirth DF, Winzeler EA. PMID: 29326268.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    18. Directing Stem Cell Fate: The Synthetic Natural Product Connection. Chem Rev. 2017 Sep 27; 117(18):12052-12086. Johnson TC, Siegel D. PMID: 28771328.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Synthetic Route Development for the Laboratory Preparation of Eupalinilide E. J Org Chem. 2017 05 05; 82(9):4640-4653. Johnson TC, Chin MR, Siegel D. PMID: 28440078.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    20. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. PMID: 28350171.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    21. Synthesis of Eupalinilide E, a Promoter of Human Hematopoietic Stem and Progenitor Cell Expansion. J Am Chem Soc. 2016 05 11; 138(18):6068-73. Johnson TC, Chin MR, Han T, Shen JP, Rana T, Siegel D. PMID: 27096704.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    22. Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Oncotarget. 2015 Nov 17; 6(36):39292-306. Cho J, Tremmel L, Rho O, Camelio AM, Siegel D, Slaga TJ, DiGiovanni J. PMID: 26513295.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Total Synthesis of Celastrol, Development of a Platform to Access Celastroid Natural Products. J Am Chem Soc. 2015 Sep 23; 137(37):11864-7. Camelio AM, Johnson TC, Siegel D. PMID: 26331410.
      View in: PubMed   Mentions: 3     Fields:    
    24. Dearomatization Reactions Using Phthaloyl Peroxide. Org Lett. 2015 Sep 18; 17(18):4420-3. Eliasen AM, Christy M, Claussen KR, Besandre R, Thedford RP, Siegel D. PMID: 26333308.
      View in: PubMed   Mentions:    Fields:    
    25. Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide. J Org Chem. 2015 Aug 21; 80(16):8084-95. Camelio AM, Liang Y, Eliasen AM, Johnson TC, Yuan C, Schuppe AW, Houk KN, Siegel D. PMID: 26200205.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    26. Synthesis of oxygenated oleanolic and ursolic acid derivatives with anti-inflammatory properties. Bioorg Med Chem Lett. 2015 Oct 01; 25(19):4342-6. Nelson AT, Camelio AM, Claussen KR, Cho J, Tremmel L, DiGiovanni J, Siegel D. PMID: 26259803.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. Cancer Prev Res (Phila). 2015 Sep; 8(9):817-25. Cho J, Rho O, Junco J, Carbajal S, Siegel D, Slaga TJ, DiGiovanni J. PMID: 26100520.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Expedited access to vinaxanthone and chemically edited derivatives possessing neuronal regenerative effects through ynone coupling reactions. ACS Chem Neurosci. 2015 Apr 15; 6(4):542-50. Chin MR, Zlotkowski K, Han M, Patel S, Eliasen AM, Axelrod A, Siegel D. PMID: 25615693.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    29. Semaphorin3a promotes advanced diabetic nephropathy. Diabetes. 2015 May; 64(5):1743-59. Aggarwal PK, Veron D, Thomas DB, Siegel D, Moeckel G, Kashgarian M, Tufro A. PMID: 25475434.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Preparation of phenols by phthaloyl peroxide-mediated oxidation of arenes. Nat Protoc. 2014 Nov; 9(11):2624-9. Yuan C, Eliasen AM, Camelio AM, Siegel D. PMID: 25321407.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    31. A protocol to generate phthaloyl peroxide in flow for the hydroxylation of arenes. Org Lett. 2014 Jul 18; 16(14):3628-31. Eliasen AM, Thedford RP, Claussen KR, Yuan C, Siegel D. PMID: 24988535.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    32. Complanadine A, a selective agonist for the Mas-related G protein-coupled receptor X2. Bioorg Med Chem Lett. 2014 Aug 01; 24(15):3512-5. Johnson T, Siegel D. PMID: 24930830.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    33. Small-molecule mechanism of action studies in Caenorhabditis elegans. Chembiochem. 2013 Nov 25; 14(17):2338-44. Zlotkowski K, Eliasen AM, Mitra A, Siegel D. PMID: 24123757.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    34. Metal-free oxidation of aromatic carbon-hydrogen bonds through a reverse-rebound mechanism. Nature. 2013 Jul 11; 499(7457):192-6. Yuan C, Liang Y, Hernandez T, Berriochoa A, Houk KN, Siegel D. PMID: 23846658.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    35. Syntheses of (+)-complanadine A and lycodine derivatives by regioselective [2 + 2 + 2] cycloadditions. J Org Chem. 2013 Jun 07; 78(11):5647-68. Yuan C, Chang CT, Siegel D. PMID: 23635039.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    36. Small-molecule-mediated axonal branching in Caenorhabditis elegans. Chembiochem. 2013 Feb 11; 14(3):307-10. Zlotkowski K, Pierce-Shimomura J, Siegel D. PMID: 23362121.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    37. Syntheses of xanthofulvin and vinaxanthone, natural products enabling spinal cord regeneration. Angew Chem Int Ed Engl. 2013 Mar 18; 52(12):3421-4. Axelrod A, Eliasen AM, Chin MR, Zlotkowski K, Siegel D. PMID: 23086682.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. Neuronal growth promoting sesquiterpene-neolignans; syntheses and biological studies. Org Biomol Chem. 2012 Jan 14; 10(2):383-93. Cheng X, Harzdorf N, Khaing Z, Kang D, Camelio AM, Shaw T, Schmidt CE, Siegel D. PMID: 22083452.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. Employing modular polyketide synthase ketoreductases as biocatalysts in the preparative chemoenzymatic syntheses of diketide chiral building blocks. Chem Biol. 2011 Oct 28; 18(10):1331-40. Piasecki SK, Taylor CA, Detelich JF, Liu J, Zheng J, Komsoukaniants A, Siegel DR, Keatinge-Clay AT. PMID: 22035802.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    40. Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17504-9. Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura JT. PMID: 21969584.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    41. Hippocampal and cortical neuronal growth mediated by the small molecule natural product clovanemagnolol. Bioorg Med Chem Lett. 2011 Aug 15; 21(16):4808-12. Khaing Z, Kang D, Camelio AM, Schmidt CE, Siegel D. PMID: 21757342.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. ACS Chem Biol. 2011 May 20; 6(5):511-9. Zhang M, Cho EJ, Burstein G, Siegel D, Zhang Y. PMID: 21348431.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. Hydroxyl-directed cyclizations of 1,6-enynes. Org Lett. 2011 Mar 18; 13(6):1517-9. Camelio AM, Barton T, Guo F, Shaw T, Siegel D. PMID: 21314167.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    44. Synthesis of (+)-complanadine A, an inducer of neurotrophic factor excretion. J Am Chem Soc. 2010 May 05; 132(17):5924-5. Yuan C, Chang CT, Axelrod A, Siegel D. PMID: 20387896.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    45. Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol. Org Lett. 2010 Mar 19; 12(6):1304-7. Cheng X, Harzdorf NL, Shaw T, Siegel D. PMID: 20158263.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    46. A robust platform for the synthesis of new tetracycline antibiotics. J Am Chem Soc. 2008 Dec 31; 130(52):17913-27. Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel DR, Wang YM, Myers AG. PMID: 19053822.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    47. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angew Chem Int Ed Engl. 2007; 46(46):8840-4. Tsukano C, Siegel DR, Danishefsky SJ. PMID: 17935090.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    48. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Org Lett. 2006 Feb 02; 8(3):423-5. Liu H, Siegel DR, Danishefsky SJ. PMID: 16435850.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    49. Total synthesis of garsubellin A. J Am Chem Soc. 2006 Feb 01; 128(4):1048-9. Siegel DR, Danishefsky SJ. PMID: 16433500.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    50. Synthesis of (-)-tetracycline. J Am Chem Soc. 2005 Jun 15; 127(23):8292-3. Charest MG, Siegel DR, Myers AG. PMID: 15941256.
      View in: PubMed   Mentions: 18     Fields:    
    51. A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science. 2005 Apr 15; 308(5720):395-8. Charest MG, Lerner CD, Brubaker JD, Siegel DR, Myers AG. PMID: 15831754.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    52. Synthesis of a broad array of highly functionalized, enantiomerically pure cyclohexanecarboxylic acid derivatives by microbial dihydroxylation of benzoic acid and subsequent oxidative and rearrangement reactions. Org Lett. 2001 Sep 06; 3(18):2923-6. Myers AG, Siegel DR, Buzard DJ, Charest MG. PMID: 11529791.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
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