Joseph Adams

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Pennsylvania State UniversityPh. D.

    Collapse Overview 
    Collapse Overview
    Our laboratory is interested in understanding how phosphorylation controls the splicing of mRNA and complexity of the human proteome. We focus attention on two families of enzymes, the SRPKs and CLKs, that phosphorylate and regulate the biological activities of SR proteins, an essential group of splicing factors that guide the assembly of the spliceosome and the selection of splice-sites in mRNA. These enzymes are not only essential for normal splicing function but are also over-expressed in many cancers making them viable targets for drug intervention in human diseases. Our laboratory applies various biochemical, biological and structural techniques to understand how these enzymes work at both the molecular and cellular levels to affect SR protein function and splicing outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    Clk Kinases and Splicing Regulation
    NIH R01GM098528Jun 1, 2012 - Aug 31, 2021
    Role: Principal Investigator
    Regulatory Pathways of SR Protein Kinases
    NIH R01GM067969Feb 1, 2004 - Jun 30, 2025
    Role: Principal Investigator
    Regulation of Nonreceptor Tyrosine Kinases through Csk.
    NIH R01GM068168Aug 20, 1997 - May 31, 2008
    Role: Principal Investigator
    NIH R01CA075112Aug 20, 1997 - Oct 31, 2003
    Role: Principal Investigator
    NIH R29GM054846Jul 1, 1996 - Jun 30, 2002
    Role: Principal Investigator
    NIH F32GM014528Jan 4, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SRPK1 regulates RNA binding in a pre-spliceosomal complex using a catalytic bypass mechanism. FEBS J. 2022 Dec; 289(23):7428-7445. Aubol BE, Adams JA. PMID: 35730996.
      View in: PubMed   Mentions: 1     Fields:    
    2. CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly. Proc Natl Acad Sci U S A. 2021 04 06; 118(14). Aubol BE, Wozniak JM, Fattet L, Gonzalez DJ, Adams JA. PMID: 33811140; PMCID: PMC8040622.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    3. Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex. Dev Cell. 2020 08 10; 54(3):302-316.e7. Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J. PMID: 32574556; PMCID: PMC7423770.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    4. A conserved sequence motif bridges two protein kinases for enhanced phosphorylation and nuclear function of a splicing factor. FEBS J. 2021 01; 288(2):566-581. Aubol BE, Fattet L, Adams JA. PMID: 32359191.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell. 2020 03 19; 180(6):1212-1227.e14. Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. PMID: 32169215; PMCID: PMC7190278.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    6. Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser-Arg protein substrate. J Biol Chem. 2019 06 14; 294(24):9631-9641. George A, Aubol BE, Fattet L, Adams JA. PMID: 31064840; PMCID: PMC6579451.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus. Mol Cell. 2018 09 06; 71(5):872. Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. PMID: 30193100; PMCID: PMC6173192.
      View in: PubMed   Mentions: 5     Fields:    
    8. Molecular interactions connecting the function of the serine-arginine-rich protein SRSF1 to protein phosphatase 1. J Biol Chem. 2018 10 26; 293(43):16751-16760. Aubol BE, Serrano P, Fattet L, Wüthrich K, Adams JA. PMID: 30185622; PMCID: PMC6204901.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    9. Designing bacterial signaling interactions with coevolutionary landscapes. PLoS One. 2018; 13(8):e0201734. Cheng RR, Haglund E, Tiee NS, Morcos F, Levine H, Adams JA, Jennings PA, Onuchic JN. PMID: 30125296; PMCID: PMC6101370.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    10. Mobilization of a splicing factor through a nuclear kinase-kinase complex. Biochem J. 2018 02 14; 475(3):677-690. Aubol BE, Keshwani MM, Fattet L, Adams JA. PMID: 29335301; PMCID: PMC6293969.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    11. Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform. J Mol Biol. 2017 07 07; 429(14):2178-2191. Aubol BE, Hailey KL, Fattet L, Jennings PA, Adams JA. PMID: 28576472; PMCID: PMC5536852.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. PLoS Biol. 2016 Nov; 14(11):e2000127. Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. PMID: 27902690; PMCID: PMC5130182.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    13. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. PMID: 27397683; PMCID: PMC4941815.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    14. Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif. J Mol Biol. 2016 06 05; 428(11):2430-2445. Serrano P, Aubol BE, Keshwani MM, Forli S, Ma CT, Dutta SK, Geralt M, Wüthrich K, Adams JA. PMID: 27091468; PMCID: PMC4884534.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    15. Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates. Biochem J. 2015 Dec 15; 472(3):329-38. Keshwani MM, Hailey KL, Aubol BE, Fattet L, McGlone ML, Jennings PA, Adams JA. PMID: 26443864; PMCID: PMC5053023.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One. 2015; 10(6):e0127724. Barkho S, Pierce LC, Li S, Adams JA, Jennings PA. PMID: 26030592; PMCID: PMC4452171.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1. J Biol Chem. 2015 Jul 10; 290(28):17269-81. Jamros MA, Aubol BE, Keshwani MM, Zhang Z, Stamm S, Adams JA. PMID: 26013829; PMCID: PMC4498066.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. PMID: 25529026; PMCID: PMC5053020.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    19. Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PLoS One. 2014; 9(9):e106590. Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR. PMID: 25181488; PMCID: PMC4152333.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    20. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 24869919; PMCID: PMC5056641.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    21. Recruiting a silent partner for activation of the protein kinase SRPK1. Biochemistry. 2014 Jul 22; 53(28):4625-34. Aubol BE, Adams JA. PMID: 24984036; PMCID: PMC4108178.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    22. Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate. Biochemistry. 2013 Oct 29; 52(43):7595-605. Aubol BE, Jamros MA, McGlone ML, Adams JA. PMID: 24074032; PMCID: PMC3865722.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol. 2013; 9(9):e1003188. Barkho S, Pierce LC, McGlone ML, Li S, Woods VL, Walker RC, Adams JA, Jennings PA. PMID: 24039559; PMCID: PMC3764022.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    24. Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol. 2013 Aug 23; 425(16):2894-909. Aubol BE, Plocinik RM, Hagopian JC, Ma CT, McGlone ML, Bandyopadhyay R, Fu XD, Adams JA. PMID: 23707382; PMCID: PMC3860265.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    25. Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry. 2013 May 21; 52(20):3588-600. Zhou X, Chou TF, Aubol BE, Park CJ, Wolfenden R, Adams J, Wagner CR. PMID: 23614568; PMCID: PMC3835729.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. Substrate-specific reorganization of the conformational ensemble of CSK implicates novel modes of kinase function. PLoS Comput Biol. 2012; 8(9):e1002695. Jamros MA, Oliveira LC, Whitford PC, Onuchic JN, Adams JA, Jennings PA. PMID: 23028292; PMCID: PMC3447962.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    27. Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation. Biochemistry. 2012 Aug 21; 51(33):6584-94. Aubol BE, Plocinik RM, McGlone ML, Adams JA. PMID: 22839969; PMCID: PMC3718016.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    28. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell. 2012 Aug 10; 47(3):422-33. Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. PMID: 22727668; PMCID: PMC3418396.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    29. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem. 2012 Apr 27; 287(18):14672-80. Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor SS. PMID: 22334660; PMCID: PMC3340281.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    30. C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res. 2012 May; 40(9):4025-39. Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. PMID: 22210893; PMCID: PMC3351148.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    31. Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry. 2011 Aug 16; 50(32):6888-900. Aubol BE, Adams JA. PMID: 21728354; PMCID: PMC3153611.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    32. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 01; 410(1):131-45. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings PA, Adams JA. PMID: 21600902; PMCID: PMC3121894.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J. 2011 Feb; 278(4):587-97. Ghosh G, Adams JA. PMID: 21205204; PMCID: PMC3079193.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    34. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol. 2010 Oct 29; 403(3):386-404. Ma CT, Ghosh G, Fu XD, Adams JA. PMID: 20826166; PMCID: PMC2994579.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    35. Proteins at work: a combined small angle X-RAY scattering and theoretical determination of the multiple structures involved on the protein kinase functional landscape. J Biol Chem. 2010 Nov 12; 285(46):36121-8. Jamros MA, Oliveira LC, Whitford PC, Onuchic JN, Adams JA, Blumenthal DK, Jennings PA. PMID: 20801888; PMCID: PMC2975234.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    36. Structure and activity of CPNGRC: a modified CD13/APN peptidic homing motif. Chem Biol Drug Des. 2010 Jun; 75(6):551-62. Plesniak LA, Salzameda B, Hinderberger H, Regan E, Kahn J, Mills SA, Teriete P, Yao Y, Jennings P, Marassi F, Adams JA. PMID: 20374250; PMCID: PMC2890305.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    37. Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry. 2009 Dec 08; 48(48):11432-40. Huynh N, Ma CT, Giang N, Hagopian J, Ngo J, Adams J, Ghosh G. PMID: 19886675; PMCID: PMC3322178.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    38. Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2009 Jul 24; 390(4):618-34. Ma CT, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 19477182; PMCID: PMC2741142.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    39. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009 Feb 15; 23(4):482-95. Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. PMID: 19240134; PMCID: PMC2648651.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    40. Ligand-induced global transitions in the catalytic domain of protein kinase A. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3023-8. Hyeon C, Jennings PA, Adams JA, Onuchic JN. PMID: 19204278; PMCID: PMC2651249.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    41. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. PMID: 18687337; PMCID: PMC2741138.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    42. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14; 29(5):563-76. Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. PMID: 18342604; PMCID: PMC2852395.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    43. Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase. Chem Biol Drug Des. 2008 Jan; 71(1):28-35. Plesniak LA, Botsch K, Leibrand M, Kelly M, Sem D, Adams JA, Jennings P. PMID: 18093089.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    44. Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B. 2007 Nov 29; 111(47):13455-64. Valiev M, Yang J, Adams JA, Taylor SS, Weare JH. PMID: 17983217.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    45. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol. 2008 Feb 08; 376(1):55-68. Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 18155240.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    46. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10; 282(32):23036-43. Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. PMID: 17517895.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    47. SR protein kinase 1 is resilient to inactivation. Structure. 2007 Jan; 15(1):123-33. Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. PMID: 17223538.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    48. The RGG domain of Npl3p recruits Sky1p through docking interactions. J Mol Biol. 2007 Mar 16; 367(1):249-61. Lukasiewicz R, Nolen B, Adams JA, Ghosh G. PMID: 17239901.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    49. A novel disulfide bond in the SH2 Domain of the C-terminal Src kinase controls catalytic activity. J Mol Biol. 2007 Feb 02; 365(5):1460-8. Mills JE, Whitford PC, Shaffer J, Onuchic JN, Adams JA, Jennings PA. PMID: 17137590; PMCID: PMC2741090.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    50. SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk. J Biol Chem. 2006 Dec 08; 281(49):38004-12. Lieser SA, Shaffer J, Adams JA. PMID: 17018524.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell. 2006 Feb; 17(2):876-85. Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. PMID: 16319169; PMCID: PMC1356596.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    52. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem. 2005 Dec 16; 280(50):41761-8. Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. PMID: 16223727.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    53. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. PMID: 16209947.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    54. Coupling phosphoryl transfer and substrate interactions in protein kinases. Biochim Biophys Acta. 2005 Dec 30; 1754(1-2):191-9. Lieser SA, Aubol BE, Wong L, Jennings PA, Adams JA. PMID: 16213199.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol. 2005 Aug 05; 351(1):131-43. Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings PA. PMID: 16002086.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    56. Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition. J Biol Chem. 2005 Mar 04; 280(9):7769-76. Lieser SA, Shindler C, Aubol BE, Lee S, Sun G, Adams JA. PMID: 15623523.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    57. Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol. 2004 Jul 30; 341(1):93-106. Wong L, Lieser S, Chie-Leon B, Miyashita O, Aubol B, Shaffer J, Onuchic JN, Jennings PA, Woods VL, Adams JA. PMID: 15312765.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    58. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem. 2004 Jul 16; 279(29):30182-8. Aubol BE, Ungs L, Lukasiewicz R, Ghosh G, Adams JA. PMID: 15145958.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    59. Communication pathways between the nucleotide pocket and distal regulatory sites in protein kinases. Acc Chem Res. 2004 May; 37(5):304-11. Wong L, Jennings PA, Adams JA. PMID: 15147171.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    60. Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p. Biochemistry. 2003 Nov 11; 42(44):12813-20. Aubol BE, Nolen B, Shaffer J, Ghosh G, Adams JA. PMID: 14596595.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    61. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12601-6. Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. PMID: 14555757; PMCID: PMC240664.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    62. The role of the putative catalytic base in the phosphoryl transfer reaction in a protein kinase: first-principles calculations. J Am Chem Soc. 2003 Aug 20; 125(33):9926-7. Valiev M, Kawai R, Adams JA, Weare JH. PMID: 12914447.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    63. Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography. Biochemistry. 2003 Aug 19; 42(32):9575-85. Nolen B, Ngo J, Chakrabarti S, Vu D, Adams JA, Ghosh G. PMID: 12911299.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    64. Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model? Biochemistry. 2003 Jan 28; 42(3):601-7. Adams JA. PMID: 12534271.
      View in: PubMed   Mentions: 87     Fields:    Translation:Cells
    65. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem. 2003 Mar 21; 278(12):10613-8. Moore MJ, Adams JA, Taylor SS. PMID: 12499371.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    66. Probing the nucleotide binding domain of the osmoregulator EnvZ using fluorescent nucleotide derivatives. Biochemistry. 2002 Nov 26; 41(47):13876-82. Plesniak L, Horiuchi Y, Sem D, Meinenger D, Stiles L, Shaffer J, Jennings PA, Adams JA. PMID: 12437344.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    67. Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol. 2002 Nov 08; 323(5):871-81. Hamuro Y, Wong L, Shaffer J, Kim JS, Stranz DD, Jennings PA, Woods VL, Adams JA. PMID: 12417200.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    68. Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases. Biochemistry. 2002 Aug 06; 41(31):10002-9. Aubol BE, Nolen B, Vu D, Ghosh G, Adams JA. PMID: 12146964.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    69. Nucleotide release and associated conformational changes regulate function in the COOH-terminal Src kinase, Csk. Biochemistry. 2001 Sep 18; 40(37):11149-55. Shaffer J, Sun G, Adams JA. PMID: 11551213.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    70. Electrostatic environment surrounding the activation loop phosphotyrosine in the oncoprotein v-Fps. Biochemistry. 2001 Aug 28; 40(34):10078-86. Leon BC, Tsigelny I, Adams JA. PMID: 11513586.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    71. Kinetic and catalytic mechanisms of protein kinases. Chem Rev. 2001 Aug; 101(8):2271-90. Adams JA. PMID: 11749373.
      View in: PubMed   Mentions: 225     Fields:    Translation:Cells
    72. Structural characterization of protein kinase A as a function of nucleotide binding. Hydrogen-deuterium exchange studies using matrix-assisted laser desorption ionization-time of flight mass spectrometry detection. J Biol Chem. 2001 Apr 27; 276(17):14204-11. Andersen MD, Shaffer J, Jennings PA, Adams JA. PMID: 11278927.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    73. Catalytic assessment of the glycine-rich loop of the v-Fps oncoprotein using site-directed mutagenesis. Biochemistry. 2000 Oct 31; 39(43):13276-84. Hirai TJ, Tsigelny I, Adams JA. PMID: 11052681.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    74. Insights into nucleotide binding in protein kinase A using fluorescent adenosine derivatives. Protein Sci. 2000 Sep; 9(9):1818-27. Ni Q, Shaffer J, Adams JA. PMID: 11045627; PMCID: PMC2144695.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    75. Substrate specificity of the oncoprotein v-Fps: site-specific mutagenesis of the putative P+1 pocket. Biochemistry. 2000 Jan 11; 39(1):255-62. Konkol L, Hirai TJ, Adams JA. PMID: 10625501.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    76. Detection of conformational changes along the kinetic pathway of protein kinase A using a catalytic trapping technique. Biochemistry. 1999 Sep 14; 38(37):12072-9. Shaffer J, Adams JA. PMID: 10508411.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    77. An ATP-linked structural change in protein kinase A precedes phosphoryl transfer under physiological magnesium concentrations. Biochemistry. 1999 Apr 27; 38(17):5572-81. Shaffer J, Adams JA. PMID: 10220345.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    78. Mutations in the activation loop tyrosine of the oncoprotein v-Fps. Biochemistry. 1998 Dec 22; 37(51):17875-81. Saylor P, Hanna E, Adams JA. PMID: 9922154.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    79. A second magnesium ion is critical for ATP binding in the kinase domain of the oncoprotein v-Fps. Biochemistry. 1998 Sep 08; 37(36):12624-30. Saylor P, Wang C, Hirai TJ, Adams JA. PMID: 9730835.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    80. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 1998 May 26; 37(21):7708-15. Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. PMID: 9601030.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    81. Participation of ADP dissociation in the rate-determining step in cAMP-dependent protein kinase. Biochemistry. 1997 Dec 16; 36(50):15733-8. Zhou J, Adams JA. PMID: 9398302.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    82. Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature. 1997 Aug 28; 388(6645):882-7. Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY. PMID: 9278050.
      View in: PubMed   Mentions: 894     Fields:    Translation:HumansCells
    83. Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry. 1997 Jun 03; 36(22):6717-24. Lew J, Taylor SS, Adams JA. PMID: 9184152.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    84. Is there a catalytic base in the active site of cAMP-dependent protein kinase? Biochemistry. 1997 Mar 11; 36(10):2977-84. Zhou J, Adams JA. PMID: 9062128.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    85. Insight into tyrosine phosphorylation in v-Fps using proton inventory techniques. Biochemistry. 1996 Aug 20; 35(33):10949-56. Adams JA. PMID: 8718888.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    86. Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit. Protein Sci. 1996 Jul; 5(7):1316-24. Grant BD, Tsigelny I, Adams JA, Taylor SS. PMID: 8819164; PMCID: PMC2143462.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    87. Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan. J Med Chem. 1996 Apr 26; 39(9):1763-6. Evenson DA, Adams J, McIvor RS, Wagner CR. PMID: 8627598.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    88. Pre-steady-state kinetic analysis of cAMP-dependent protein kinase using rapid quench flow techniques. Biochemistry. 1996 Feb 13; 35(6):2022-9. Grant BD, Adams JA. PMID: 8639687.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    89. Rate-determining steps for tyrosine phosphorylation by the kinase domain of v-fps. Biochemistry. 1996 Feb 06; 35(5):1533-9. Wang C, Lee TR, Lawrence DS, Adams JA. PMID: 8634284.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    90. Bacterial expression, purification and preliminary kinetic description of the kinase domain of v-fps. Protein Eng. 1995 Jun; 8(6):609-14. Gish G, McGlone ML, Pawson T, Adams JA. PMID: 8532686.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    Joseph's Networks
    Concepts (271)
    Derived automatically from this person's publications.
    Co-Authors (19)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department