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    William Gerwick

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0212
    CA La Jolla 92093
    Phone858-534-0578
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      Collapse Research 
      Collapse Research Activities and Funding
      Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
      NIH/NIGMS R01GM118815Jan 12, 2017 - Dec 31, 2020
      Role: Principal Investigator
      Development of Gallinamide A-Inspired Agents for the Treatment of Chagas? Disease
      NIH/NIAID R21AI127505Dec 7, 2016 - Nov 30, 2018
      Role: Principal Investigator
      Tools for rapid and accurate structure elucidation of natural products
      NIH/NIGMS R01GM107550Sep 5, 2013 - Apr 30, 2021
      Role: Principal Investigator
      Huntington's Disease Natural Product Drug Discovery
      NIH/NIA R21AG038772Sep 1, 2011 - Aug 31, 2014
      Role: Principal Investigator
      Biosynthetic Analysis of Marine Cyanobacterial Pathways
      NIH/NCI R01CA108874Jul 1, 2004 - May 31, 2016
      Role: Principal Investigator
      ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms
      NIH/FIC U01TW006634Sep 27, 2003 - May 31, 2014
      Role: Principal Investigator
      Training Program in Marine Biotechnology
      NIH/NIGMS T32GM067550Jul 1, 2003 - Jun 30, 2020
      Role: Principal Investigator
      US-Japan Seminar on Marine Bioorganic Chemistry
      NIH/NCI R13CA102377Jun 1, 2003 - May 31, 2004
      Role: Principal Investigator
      Neurotoxins from Marine Algae and Cyanobacteria
      NIH/NINDS R01NS053398Jul 1, 2001 - Jun 30, 2016
      Role: Principal Investigator
      Neurotoxins from Marine Algae and Cyanobacteria
      NIH/NIGMS R01GM063554Jul 1, 2001 - Jun 30, 2005
      Role: Principal Investigator
      EICOSANOID BIOSYNTHESIS IN MARINE PLANTS
      NIH/FIC F06TW001616Jun 21, 1991
      Role: Principal Investigator
      Targeted Discovery of Marine-derived Anticancer Leads
      NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
      Role: Co-Investigator
      SMALL INSTRUMENTATION PROGRAM
      NIH/NIEHS S15ES005267Aug 15, 1989 - Jul 31, 1990
      Role: Principal Investigator
      ANTINEOPLASTIC AGENTS FROM BLUE GREEN ALGAE
      NIH/NCI R23CA042850Jul 1, 1986 - Jun 30, 1990
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick W. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 Aug 25; 80(8):2328-2334. PMID: 28783331.
        View in: PubMed
      2. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick W, Ottilie S. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 Aug 10; 60(15):6721-6732. PMID: 28696697.
        View in: PubMed
      3. Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick W. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 May 26; 80(5):1514-1521. PMID: 28448144.
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      4. Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick W, Gerwick L. Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proc Natl Acad Sci U S A. 2017 Mar 21; 114(12):3198-3203. PMID: 28265051.
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      5. Cummings SL, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick W, Gerwick L. A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. BMC Microbiol. 2016 Aug 30; 16(1):198. PMID: 27577966; PMCID: PMC5006271.
      6. Maloney FP, Gerwick L, Gerwick W, Sherman DH, Smith JL. Anatomy of the ß-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37):10316-21. PMID: 27573844; PMCID: PMC5027445 [Available on 03/13/17].
      7. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick W, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 Aug 09; 34(8):828-837. PMID: 27504778.
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      8. Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick W, Parker JE, Schroeder JI. Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants. PLoS One. 2016; 11(5):e0155937. PMID: 27219122; PMCID: PMC4878808.
      9. Kleigrewe K, Gerwick L, Sherman DH, Gerwick W. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Nat Prod Rep. 2016 Feb; 33(2):348-64. PMID: 26758451.
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      10. Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick W. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem. 2016 Jan; 17(2):164-73. PMID: 26769357; PMCID: PMC4878910 [Available on 01/01/17].
      11. Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick W. Kalkipyrone B, a marine cyanobacterial ?-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. 2016 Feb; 122:113-118. PMID: 26632528; PMCID: PMC4724546 [Available on 02/01/17].
      12. Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick W, Mangoni A, Costantino V. Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle. Environ Sci Technol. 2015 Dec 15; 49(24):14301-10. PMID: 26567695; PMCID: PMC4851459 [Available on 12/15/16].
      13. Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick W. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. J Ind Microbiol Biotechnol. 2016 Mar; 43(2-3):313-24. PMID: 26578313.
        View in: PubMed
      14. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick W. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. J Org Chem. 2015 Aug 21; 80(16):7849-55. PMID: 26222145.
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      15. Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick W, Balskus EP. Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria. Angew Chem Int Ed Engl. 2015 Sep 14; 54(38):11063-7. PMID: 26235728.
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      16. Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick W. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. PLoS One. 2015; 10(7):e0133297. PMID: 26222584; PMCID: PMC4519256.
      17. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick W. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. PMID: 26149623; PMCID: PMC4681511.
      18. Moore BS, Gerwick W. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. J Nat Prod. 2015 Mar 27; 78(3):347-8. PMID: 25814030.
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      19. Morgan JB, Liu Y, Coothankandaswamy V, Mahdi F, Jekabsons MB, Gerwick W, Valeriote FA, Zhou YD, Nagle DG. Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs. 2015 Mar 20; 13(3):1552-68. PMID: 25803180; PMCID: PMC4377999.
      20. Rho JR, Subramaniam G, Choi H, Kim EH, Ng SP, Yoganathan K, Ng S, Buss AD, Butler MS, Gerwick W. Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp. Org Lett. 2015 Mar 20; 17(6):1377-80. PMID: 25723256.
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      21. Bertin MJ, Schwartz SL, Lee J, Korobeynikov A, Dorrestein PC, Gerwick L, Gerwick W. Spongosine production by a Vibrio harveyi strain associated with the sponge Tectitethya crypta. J Nat Prod. 2015 Mar 27; 78(3):493-9. PMID: 25668560.
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      22. Cao Z, Li X, Zou X, Greenwood M, Gerwick W, Murray TF. Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons. Mar Drugs. 2015 Feb 10; 13(2):903-19. PMID: 25675001; PMCID: PMC4344608.
      23. Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, Kelly JX, Gerwick W, Proteau PJ, Ishmael JE, McPhail KL. Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. J Nat Prod. 2015 Mar 27; 78(3):413-20. PMID: 25562664; PMCID: PMC4380200.
      24. Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick W, Murray TF, Maio WA. Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists. J Nat Prod. 2014 Nov 26; 77(11):2553-60. PMID: 25343669; PMCID: PMC4251536.
      25. Vogel CV, Pietraszkiewicz H, Sabry OM, Gerwick W, Valeriote FA, Vanderwal CD. Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors. Angew Chem Int Ed Engl. 2014 Nov 03; 53(45):12205-9. PMID: 25220828; PMCID: PMC4219742.
      26. Mevers E, Matainaho T, Allara' M, Di Marzo V, Gerwick W. Mooreamide A: a cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii. Lipids. 2014 Nov; 49(11):1127-32. PMID: 25204580.
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      27. Moree WJ, McConnell OJ, Nguyen DD, Sanchez LM, Yang YL, Zhao X, Liu WT, Boudreau PD, Srinivasan J, Atencio L, Ballesteros J, Gavilán RG, Torres-Mendoza D, Guzmán HM, Gerwick W, Gutiérrez M, Dorrestein PC. Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol. 2014 Oct 17; 9(10):2300-8. PMID: 25058318; PMCID: PMC4201335.
      28. Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick W, Moore BS. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem Biol. 2014 Jun 19; 21(6):782-91. PMID: 24930969; PMCID: PMC4103027.
      29. Xu DX, Sun P, Kurtán T, Mándi A, Tang H, Liu B, Gerwick W, Wang ZW, Zhang W. Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. J Nat Prod. 2014 May 23; 77(5):1179-84. PMID: 24749951.
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      30. Gong J, Sun P, Jiang N, Riccio R, Lauro G, Bifulco G, Li TJ, Gerwick W, Zhang W. New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei. Org Lett. 2014 Apr 18; 16(8):2224-7. PMID: 24694058.
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      31. Almeida C, Ortega H, Higginbotham S, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick W, Cubilla-Rios L. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Lett Appl Microbiol. 2014 Jul; 59(1):58-64. PMID: 24612068.
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      32. Mevers E, Haeckl FP, Boudreau PD, Byrum T, Dorrestein PC, Valeriote FA, Gerwick W. Lipopeptides from the tropical marine cyanobacterium Symploca sp. J Nat Prod. 2014 Apr 25; 77(4):969-75. PMID: 24588245; PMCID: PMC4002153.
      33. Zhou W, Li J, E HC, Liu BS, Tang H, Gerwick W, Hua HM, Zhang W. Briarane diterpenes from the South China Sea gorgonian coral, Junceella gemmacea. Mar Drugs. 2014 Jan 27; 12(2):589-600. PMID: 24473165; PMCID: PMC3944505.
      34. Coates RC, Podell S, Korobeynikov A, Lapidus A, Pevzner P, Sherman DH, Allen EE, Gerwick L, Gerwick W. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One. 2014; 9(1):e85140. PMID: 24475038; PMCID: PMC3903477.
      35. Carneiro VM, Avila CM, Balunas MJ, Gerwick W, Pilli RA. Coibacins A and B: total synthesis and stereochemical revision. J Org Chem. 2014 Jan 17; 79(2):630-42. PMID: 24359482; PMCID: PMC3962765.
      36. Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick W. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod. 2014 Jan 24; 77(1):92-9. PMID: 24364476; PMCID: PMC3932306.
      37. Winnikoff JR, Glukhov E, Watrous J, Dorrestein PC, Gerwick W. Quantitative molecular networking to profile marine cyanobacterial metabolomes. J Antibiot (Tokyo). 2014 Jan; 67(1):105-12. PMID: 24281659.
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      38. Trentacoste EM, Shrestha RP, Smith SR, Glé C, Hartmann AC, Hildebrand M, Gerwick W. Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19748-53. PMID: 24248374; PMCID: PMC3856844.
      39. Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick W, Sherman DH, Smith JL. Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem Biol. 2013 Nov 21; 20(11):1340-51. PMID: 24183970; PMCID: PMC3870462.
      40. Pavlik CM, Wong CY, Ononye S, Lopez DD, Engene N, McPhail KL, Gerwick W, Balunas MJ. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22; 76(11):2026-33. PMID: 24164245; PMCID: PMC3879121.
      41. Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore BS, Gerwick W, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo). 2014 Jan; 67(1):99-104. PMID: 24149839; PMCID: PMC3919142.
      42. Mevers E, Byrum T, Gerwick W. Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens. J Nat Prod. 2013 Sep 27; 76(9):1810-4. PMID: 24044577; PMCID: PMC3962764.
      43. Yang JY, Sanchez LM, Rath CM, Liu X, Boudreau PD, Bruns N, Glukhov E, Wodtke A, de Felicio R, Fenner A, Wong WR, Linington RG, Zhang L, Debonsi HM, Gerwick W, Dorrestein PC. Molecular networking as a dereplication strategy. J Nat Prod. 2013 Sep 27; 76(9):1686-99. PMID: 24025162; PMCID: PMC3936340.
      44. Tan LT, Okino T, Gerwick W. Bouillonamide: a mixed polyketide-peptide cytotoxin from the marine cyanobacterium Moorea bouillonii. Mar Drugs. 2013 Aug 19; 11(8):3015-24. PMID: 23966034; PMCID: PMC3766879.
      45. Leão PN, Costa M, Ramos V, Pereira AR, Fernandes VC, Domingues VF, Gerwick W, Vasconcelos VM, Martins R. Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found in both filamentous and unicellular marine strains. PLoS One. 2013; 8(7):e69562. PMID: 23922738; PMCID: PMC3726634.
      46. Della Sala G, Hochmuth T, Costantino V, Teta R, Gerwick W, Gerwick L, Piel J, Mangoni A. Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environ Microbiol Rep. 2013 Dec; 5(6):809-18. PMID: 24249289; PMCID: PMC3908369.
      47. Ongley SE, Bian X, Zhang Y, Chau R, Gerwick W, Müller R, Neilan BA. High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. ACS Chem Biol. 2013 Sep 20; 8(9):1888-93. PMID: 23751865; PMCID: PMC3880125.
      48. Leão PN, Ramos V, Gonçalves PB, Viana F, Lage OM, Gerwick W, Vasconcelos VM. Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria. Mar Drugs. 2013 Apr 22; 11(4):1316-35. PMID: 23609580; PMCID: PMC3705407.
      49. Ortega HE, Graupner PR, Asai Y, Tendyke K, Qiu D, Shen YY, Rios N, Arnold AE, Coley PD, Kursar TA, Gerwick W, Cubilla-Rios L. Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194. J Nat Prod. 2013 Apr 26; 76(4):741-4. PMID: 23560689.
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      50. Engene N, Gunasekera SP, Gerwick W, Paul VJ. Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria. Appl Environ Microbiol. 2013 Mar; 79(6):1882-8. PMID: 23315747; PMCID: PMC3592240.
      51. Gerwick W, Fenner AM. Drug discovery from marine microbes. Microb Ecol. 2013 May; 65(4):800-6. PMID: 23274881; PMCID: PMC3640700.
      52. Kim EJ, Lee JH, Choi H, Pereira AR, Ban YH, Yoo YJ, Kim E, Park JW, Sherman DH, Gerwick W, Yoon YJ. Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Org Lett. 2012 Dec 07; 14(23):5824-7. PMID: 23148802; PMCID: PMC3536539.
      53. George J, Baden DG, Gerwick W, Murray TF. Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19840-5. PMID: 23150561; PMCID: PMC3511701.
      54. McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick W, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol. 2012 Dec 21; 7(12):1994-2003. PMID: 22991895; PMCID: PMC3528841.
      55. Boudreau PD, Byrum T, Liu WT, Dorrestein PC, Gerwick W. Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. J Nat Prod. 2012 Sep 28; 75(9):1560-70. PMID: 22924493; PMCID: PMC3521035.
      56. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick W. Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org Lett. 2012 Aug 03; 14(15):3878-81. PMID: 22794317; PMCID: PMC3449157.
      57. Gonzalez DJ, Xu Y, Yang YL, Esquenazi E, Liu WT, Edlund A, Duong T, Du L, Molnár I, Gerwick W, Jensen PR, Fischbach M, Liaw CC, Straight P, Nizet V, Dorrestein PC. Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics. 2012 Aug 30; 75(16):5069-76. PMID: 22641157; PMCID: PMC3543690.
      58. Choi H, Mascuch SJ, Villa FA, Byrum T, Teasdale ME, Smith JE, Preskitt LB, Rowley DC, Gerwick L, Gerwick W. Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chem Biol. 2012 May 25; 19(5):589-98. PMID: 22633410; PMCID: PMC3361693.
      59. Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick W. Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. J Org Chem. 2012 May 04; 77(9):4198-208. PMID: 22489775; PMCID: PMC3345101.
      60. Charusanti P, Fong NL, Nagarajan H, Pereira AR, Li HJ, Abate EA, Su Y, Gerwick W, Palsson BO. Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. PLoS One. 2012; 7(3):e33727. PMID: 22470465; PMCID: PMC3312335.
      61. Pereira AR, Kale AJ, Fenley AT, Byrum T, Debonsi HM, Gilson MK, Valeriote FA, Moore BS, Gerwick W. The carmaphycins: new proteasome inhibitors exhibiting an a,ß-epoxyketone warhead from a marine cyanobacterium. Chembiochem. 2012 Apr 16; 13(6):810-7. PMID: 22383253; PMCID: PMC3393770.
      62. Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick W. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS J. 2012 Apr; 279(7):1243-51. PMID: 22314229.
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      63. Martínez-Luis S, Cherigo L, Arnold E, Spadafora C, Gerwick W, Cubilla-Rios L. Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Nat Prod Commun. 2012 Feb; 7(2):165-8. PMID: 22474943.
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      64. Gerwick W, Moore BS. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol. 2012 Jan 27; 19(1):85-98. PMID: 22284357; PMCID: PMC3345185.
      65. Leão PN, Engene N, Antunes A, Gerwick W, Vasconcelos V. The chemical ecology of cyanobacteria. Nat Prod Rep. 2012 Mar; 29(3):372-91. PMID: 22237837; PMCID: PMC4161925.
      66. Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick W, Sherman DH, Smith JL. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Sci. 2012 Feb; 21(2):239-48. PMID: 22124946; PMCID: PMC3324768.
      67. Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick W. Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. J Nat Prod. 2012 Jan 27; 75(1):60-6. PMID: 22148360; PMCID: PMC3336157.
      68. Choi H, Proteau PJ, Byrum T, Pereira AR, Gerwick W. Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata. Phytochemistry. 2012 Jan; 73(1):134-41. PMID: 22071135.
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      69. Malloy KL, Choi H, Fiorilla C, Valeriote FA, Matainaho T, Gerwick W. Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):683-8. PMID: 22104152; PMCID: PMC3248991.
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      155. Sabry OM, Andrews S, McPhail KL, Goeger DE, Yokochi A, LePage KT, Murray TF, Gerwick W. Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme. J Nat Prod. 2005 Jul; 68(7):1022-30. PMID: 16038542.
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      156. Han B, Goeger D, Maier CS, Gerwick W. The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Org Chem. 2005 Apr 15; 70(8):3133-9. PMID: 15822975.
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      157. LePage KT, Goeger D, Yokokawa F, Asano T, Shioiri T, Gerwick W, Murray TF. The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons. Toxicol Lett. 2005 Aug 14; 158(2):133-9. PMID: 16039402.
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      158. Andrianasolo EH, Gross H, Goeger D, Musafija-Girt M, McPhail K, Leal RM, Mooberry SL, Gerwick W. Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Org Lett. 2005 Mar 31; 7(7):1375-8. PMID: 15787510.
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      159. Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwick W. Marine natural products as anticancer drugs. Mol Cancer Ther. 2005 Feb; 4(2):333-42. PMID: 15713904.
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      160. LePage KT, Dickey RW, Gerwick W, Jester EL, Murray TF. On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Crit Rev Neurobiol. 2005; 17(1):27-50. PMID: 16307526.
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      161. Edwards DJ, Gerwick W. Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase. J Am Chem Soc. 2004 Sep 22; 126(37):11432-3. PMID: 15366877.
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      162. Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J, Sherman DH, Gerwick W. Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2004 Aug; 67(8):1356-67. PMID: 15332855.
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      163. McPhail KL, France D, Cornell-Kennon S, Gerwick W. Peyssonenynes a and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga peyssonneliacaulifera. J Nat Prod. 2004 Jun; 67(6):1010-3. PMID: 15217284.
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      164. Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick W. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol. 2004 Jun; 11(6):817-33. PMID: 15217615.
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      165. Li WI, Marquez BL, Okino T, Yokokawa F, Shioiri T, Gerwick W, Murray TF. Characterization of the preferred stereochemistry for the neuropharmacologic actions of antillatoxin. J Nat Prod. 2004 Apr; 67(4):559-68. PMID: 15104484.
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      166. Gafner S, Bergeron C, McCollom MM, Cooper LM, McPhail KL, Gerwick W, Angerhofer CK. Evaluation of the efficiency of three different solvent systems to extract triterpene saponins from roots of Panax quinquefolius using high-performance liquid chromatography. J Agric Food Chem. 2004 Mar 24; 52(6):1546-50. PMID: 15030209.
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      167. Takamatsu S, Nagle DG, Gerwick W. Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion. Planta Med. 2004 Feb; 70(2):127-31. PMID: 14994189.
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      168. Han B, McPhail KL, Ligresti A, Di Marzo V, Gerwick W. Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Nat Prod. 2003 Oct; 66(10):1364-8. PMID: 14575438.
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      169. Tan LT, Sitachitta N, Gerwick W. The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2003 Jun; 66(6):764-71. PMID: 12828459.
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      170. Takamatsu S, Hodges TW, Rajbhandari I, Gerwick W, Hamann MT, Nagle DG. Marine natural products as novel antioxidant prototypes. J Nat Prod. 2003 May; 66(5):605-8. PMID: 12762791; PMCID: PMC4969048.
      171. Nogle LM, Gerwick W. Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula. J Nat Prod. 2003 Feb; 66(2):217-20. PMID: 12608852.
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      172. Nogle LM, Marquez BL, Gerwick W. Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula. Org Lett. 2003 Jan 09; 5(1):3-6. PMID: 12509876.
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      173. McPhail KL, Gerwick W. Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2003 Jan; 66(1):132-5. PMID: 12542362.
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      174. Williamson RT, Boulanger A, Vulpanovici A, Roberts MA, Gerwick W. Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. J Org Chem. 2002 Nov 15; 67(23):7927-36. PMID: 12423120.
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      175. Stevenson CS, Capper EA, Roshak AK, Marquez B, Eichman C, Jackson JR, Mattern M, Gerwick W, Jacobs RS, Marshall LA. The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther. 2002 Nov; 303(2):858-66. PMID: 12388673.
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      176. Chang Z, Flatt P, Gerwick W, Nguyen VA, Willis CL, Sherman DH. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene. 2002 Aug 21; 296(1-2):235-47. PMID: 12383521.
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      177. Tan LT, Márquez BL, Gerwick W. Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod. 2002 Jun; 65(6):925-8. PMID: 12088441.
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      178. Marquez BL, Watts KS, Yokochi A, Roberts MA, Verdier-Pinard P, Jimenez JI, Hamel E, Scheuer PJ, Gerwick W. Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod. 2002 Jun; 65(6):866-71. PMID: 12088429.
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      179. Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick W. Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA. Arch Biochem Biophys. 2002 May 01; 401(1):11-20. PMID: 12054482.
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      180. Nogle LM, Gerwick W. Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett. 2002 Apr 04; 4(7):1095-8. PMID: 11922791.
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      181. Stevenson CS, Capper EA, Roshak AK, Marquez B, Grace K, Gerwick W, Jacobs RS, Marshall LA. Scytonemin--a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflamm Res. 2002 Feb; 51(2):112-4. PMID: 11926312.
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      182. Nogle LM, Gerwick W. Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. J Nat Prod. 2002 Jan; 65(1):21-4. PMID: 11809058.
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      183. Yoo HD, Ketchum SO, France D, Bair K, Gerwick W. Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp. J Nat Prod. 2002 Jan; 65(1):51-3. PMID: 11809064.
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      184. Nguyen VA, Willis CL, Gerwick W. Synthesis of the marine natural product barbamide. Chem Commun (Camb). 2001 Oct 07; (19):1934-5. PMID: 12240226.
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      185. Nogle LM, Okino T, Gerwick W. Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2001 Jul; 64(7):983-5. PMID: 11473443.
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      186. Li WI, Berman FW, Okino T, Yokokawa F, Shioiri T, Gerwick W, Murray TF. Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7599-604. PMID: 11416227; PMCID: PMC34714.
      187. Nogle LM, Williamson RT, Gerwick W. Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species. J Nat Prod. 2001 Jun; 64(6):716-9. PMID: 11421730.
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      188. Gerwick W, Tan LT, Sitachitta N. Nitrogen-containing metabolites from marine cyanobacteria. Alkaloids Chem Biol. 2001; 57:75-184. PMID: 11705123.
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      189. Milligan KE, Marquez BL, Williamson RT, Gerwick W. Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Oct; 63(10):1440-3. PMID: 11076574.
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      190. Tan LT, Okino T, Gerwick W. Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):952-5. PMID: 10924172.
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      191. Milligan KE, Márquez B, Williamson RT, Davies-Coleman M, Gerwick W. Two new malyngamides from a Madagascan Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):965-8. PMID: 10924175.
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      192. Williamson RT, Carney JR, Gerwick W. Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems. J Nat Prod. 2000 Jun; 63(6):876-8. PMID: 10869227.
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      193. Williamson RT, Chapin EL, Carr AW, Gilbert JR, Graupner PR, Lewer P, McKamey P, Carney JR, Gerwick W. New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures. Org Lett. 2000 Feb 10; 2(3):289-92. PMID: 10814304.
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      194. Sitachitta N, Williamson RT, Gerwick W. Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. J Nat Prod. 2000 Feb; 63(2):197-200. PMID: 10691708.
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      195. Tan LT, Williamson RT, Gerwick W, Watts KS, McGough K, Jacobs R. cis,cis- and trans,trans-ceratospongamide, new bioactive cyclic heptapeptides from the Indonesian red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. J Org Chem. 2000 Jan 28; 65(2):419-25. PMID: 10813950.
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      196. Jiang ZD, Ketchum SO, Gerwick W. 5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa. Phytochemistry. 2000 Jan; 53(1):129-33. PMID: 10656420.
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      197. Berman FW, Gerwick W, Murray TF. Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon. 1999 Nov; 37(11):1645-8. PMID: 10482399.
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      198. Verdier-Pinard P, Sitachitta N, Rossi JV, Sackett DL, Gerwick W, Hamel E. Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin. Arch Biochem Biophys. 1999 Oct 01; 370(1):51-8. PMID: 10496976.
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      199. Singh IP, Milligan KE, Gerwick W. Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1999 Sep; 62(9):1333-5. PMID: 10514329.
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      200. Gerwick W, Roberts MA, Vulpanovici A, Ballantine DL. Biogenesis and biological function of marine algal oxylipins. Adv Exp Med Biol. 1999; 447:211-8. PMID: 10086197.
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      201. Márquez B, Verdier-Pinard P, Hamel E, Gerwick W. Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. Phytochemistry. 1998 Dec; 49(8):2387-9. PMID: 9887531.
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      202. Bisogno T, Melck D, De Petrocellis L, Gretskaya NM, Bezuglov VV, Sitachitta N, Gerwick W, Di Marzo V. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):515-22. PMID: 9703957.
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      203. Graber MA, Gerwick W. Kalkipyrone, a toxic gamma-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp. J Nat Prod. 1998 May; 61(5):677-80. PMID: 9599278.
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      204. Sitachitta N, Gerwick W. Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 May; 61(5):681-4. PMID: 9599279.
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      205. Hooper GJ, Orjala J, Schatzman RC, Gerwick W. Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 Apr; 61(4):529-33. PMID: 9584405.
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      206. Verdier-Pinard P, Lai JY, Yoo HD, Yu J, Marquez B, Nagle DG, Nambu M, White JD, Falck JR, Gerwick W, Day BW, Hamel E. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol. 1998 Jan; 53(1):62-76. PMID: 9443933.
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      207. Orjala J, Gerwick W. Two quinoline alkaloids from the Caribbean cyanobacterium Lyngbya majuscula. Phytochemistry. 1997 Jul; 45(5):1087-90. PMID: 9214778.
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      208. Wise ML, Rossi J, Gerwick W. Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina. Biochemistry. 1997 Mar 11; 36(10):2985-92. PMID: 9062129.
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      209. Jiang ZD, Gerwick W. Novel oxylipins from the temperate red alga Polyneura latissima: evidence for an arachidonate 9(S)-lipoxygenase. Lipids. 1997 Mar; 32(3):231-5. PMID: 9076659.
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      210. Gerwick W, Wise ML, Soderstrom K, Murray TF. Biosynthesis and cannabinoid receptor affinity of the novel eicosanoid, conjugated triene anandamide. Adv Exp Med Biol. 1997; 407:329-34. PMID: 9321972.
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      211. Soderstrom K, Murray TF, Yoo HD, Ketchum S, Milligan K, Gerwick W, Ortega MJ, Salva J. Discovery of novel cannabinoid receptor ligands from diverse marine organisms. Adv Exp Med Biol. 1997; 433:73-7. PMID: 9561107.
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      212. Gerwick W. Epoxy allylic carbocations as conceptual intermediates in the biogenesis of diverse marine oxylipins. Lipids. 1996 Dec; 31(12):1215-31. PMID: 8972454.
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      213. Orjala J, Gerwick W. Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1996 Apr; 59(4):427-30. PMID: 8699186.
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      214. Wise ML, Soderstrom K, Murray TF, Gerwick W. Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. Experientia. 1996 Jan 16; 52(1):88-92. PMID: 8575565.
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      215. Blokhin AV, Yoo HD, Geralds RS, Nagle DG, Gerwick W, Hamel E. Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. Mol Pharmacol. 1995 Sep; 48(3):523-31. PMID: 7565634.
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      216. Mikhailova MV, Bemis DL, Wise ML, Gerwick W, Norris JN, Jacobs RS. Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata. Lipids. 1995 Jul; 30(7):583-9. PMID: 7564911.
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      217. Orjala J, Nagle D, Gerwick W. Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 May; 58(5):764-8. PMID: 7623050.
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      218. Todd JS, Gerwick W. Isolation of a cyclic carbonate, a gamma-butyrolactone, and a new indole derivative from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 Apr; 58(4):586-9. PMID: 7623035.
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      219. Wise ML, Hamberg M, Gerwick W. Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina. Biochemistry. 1994 Dec 27; 33(51):15223-32. PMID: 7803384.
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      220. Proteau PJ, Rossi JV, Gerwick W. Absolute stereochemistry of neohalicholactone from the brown alga Laminaria sinclairii. J Nat Prod. 1994 Dec; 57(12):1717-9. PMID: 7714540.
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      221. Chen JL, Gerwick W, Schatzman R, Laney M. Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii. J Nat Prod. 1994 Jul; 57(7):947-52. PMID: 7964790.
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      222. Chen JL, Proteau PJ, Roberts MA, Gerwick W, Slate DL, Lee RH. Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte Poterioochromonas malhamensis. J Nat Prod. 1994 Apr; 57(4):524-7. PMID: 8021653.
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      223. Gerwick W. Structure and biosynthesis of marine algal oxylipins. Biochim Biophys Acta. 1994 Mar 24; 1211(3):243-55. PMID: 8130256.
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      224. Todd JS, Proteau PJ, Gerwick W. The absolute configuration of ecklonialactones A, B, and E, novel oxylipins from brown algae of the genera Ecklonia and Egregia. J Nat Prod. 1994 Jan; 57(1):171-4. PMID: 8158161.
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      225. Proteau PJ, Gerwick W, Garcia-Pichel F, Castenholz R. The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria. Experientia. 1993 Sep 15; 49(9):825-9. PMID: 8405307.
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      226. Proteau PJ, Gerwick W. Divinyl ethers and hydroxy fatty acids from three species of Laminaria (brown algae). Lipids. 1993 Sep; 28(9):783-7. PMID: 8231653.
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      227. Hamberg M, Gerwick W. Biosynthesis of vicinal dihydroxy fatty acids in the red alga Gracilariopsis lemaneiformis: identification of a sodium-dependent 12-lipoxygenase and a hydroperoxide isomerase. Arch Biochem Biophys. 1993 Aug 15; 305(1):115-22. PMID: 8342944.
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      228. Bernart MW, Whatley GG, Gerwick W. Unprecedented oxylipins from the marine green alga Acrosiphonia coalita. J Nat Prod. 1993 Feb; 56(2):245-59. PMID: 8463797.
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      229. Nagle DG, McClatchey WC, Gerwick W. New glycosphingolipids from the marine sponge Halichondria panicea. J Nat Prod. 1992 Jul; 55(7):1013-7. PMID: 1402953.
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      230. Jiang ZD, Gerwick W. An aldehyde-containing galactolipid from the red alga Gracilariopsis lemaneiformis. Lipids. 1991 Nov; 26(11):960-3. PMID: 1805099.
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      231. Moghaddam MF, Gerwick W. Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid, a novel eicosanoid from the marine alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Nov-Dec; 54(6):1619-24. PMID: 1667411.
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      232. Gerwick W, Moghaddam M, Hamberg M. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. Arch Biochem Biophys. 1991 Nov 01; 290(2):436-44. PMID: 1929410.
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      233. Jiang ZD, Gerwick W. Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Mar-Apr; 54(2):403-7. PMID: 1919587.
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      234. Moghaddam MF, Gerwick W, Ballantine DL. Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa. J Biol Chem. 1990 Apr 15; 265(11):6126-30. PMID: 2180942.
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      235. Solem ML, Jiang ZD, Gerwick W. Three new and bioactive icosanoids from the temperate red marine alga Farlowia mollis. Lipids. 1989 Apr; 24(4):256-60. PMID: 2547132.
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      236. Gerwick W. 6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori. J Nat Prod. 1989 Mar-Apr; 52(2):252-6. PMID: 2746254.
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      237. Gerwick W, Mrozek C, Moghaddam MF, Agarwal SK. Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material. Experientia. 1989 Feb 15; 45(2):115-21. PMID: 2493387.
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      238. Moghaddam MF, Gerwick W, Ballantine DL. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Prostaglandins. 1989 Feb; 37(2):303-8. PMID: 2727309.
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      239. Gerwick W, Whatley G. Aplysia sea hare assimilation of secondary metabolites from brown seaweed,Stypopodium zonale. J Chem Ecol. 1989 Feb; 15(2):677-83. PMID: 24271808.
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      240. Stennett DJ, Gerwick W, Egging PK, Christensen JM. Precipitate analysis from an indwelling total parenteral nutrition catheter. JPEN J Parenter Enteral Nutr. 1988 Jan-Feb; 12(1):88-92. PMID: 3125364.
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      241. Colon M, Guevara P, Gerwick W, Ballantine D. 5'-Hydroxyisoavrainvilleol, a new diphenylmethane derivative from the tropical green alga Avrainvillea nigricans. J Nat Prod. 1987 May-Jun; 50(3):368-74. PMID: 3668556.
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      242. Lopez A, Gerwick W. Two new icosapentaenoic acids from the temperate red seaweed Ptilota filicina J. Agardh. Lipids. 1987 Mar; 22(3):190-4. PMID: 3033420.
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