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William Gerwick

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0212
La Jolla CA 92093
Phone858-534-0578
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
    NIH/NIGMS R01GM118815Jan 12, 2017 - Dec 31, 2020
    Role: Principal Investigator
    Development of Gallinamide A-Inspired Agents for the Treatment of Chagas? Disease
    NIH/NIAID R21AI127505Dec 7, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Tools for rapid and accurate structure elucidation of natural products
    NIH/NIGMS R01GM107550Sep 5, 2013 - Apr 30, 2021
    Role: Principal Investigator
    Huntington's Disease Natural Product Drug Discovery
    NIH/NIA R21AG038772Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Biosynthetic Analysis of Marine Cyanobacterial Pathways
    NIH/NCI R01CA108874Jul 1, 2004 - May 31, 2016
    Role: Principal Investigator
    ICBG: "Training, Conservation and Drug Discovery using Panamanian Microorganisms
    NIH/FIC U01TW006634Sep 27, 2003 - May 31, 2014
    Role: Principal Investigator
    Training Program in Marine Biotechnology
    NIH/NIGMS T32GM067550Jul 1, 2003 - Jun 30, 2020
    Role: Principal Investigator
    US-Japan Seminar on Marine Bioorganic Chemistry
    NIH/NCI R13CA102377Jun 1, 2003 - May 31, 2004
    Role: Principal Investigator
    Neurotoxins from Marine Algae and Cyanobacteria
    NIH/NINDS R01NS053398Jul 1, 2001 - Jun 30, 2016
    Role: Principal Investigator
    Neurotoxins from Marine Algae and Cyanobacteria
    NIH/NIGMS R01GM063554Jul 1, 2001 - Jun 30, 2005
    Role: Principal Investigator
    EICOSANOID BIOSYNTHESIS IN MARINE PLANTS
    NIH/FIC F06TW001616Jun 21, 1991
    Role: Principal Investigator
    Targeted Discovery of Marine-derived Anticancer Leads
    NIH U19CA052955Sep 1, 1990 - Apr 30, 2012
    Role: Co-Investigator
    SMALL INSTRUMENTATION PROGRAM
    NIH/NIEHS S15ES005267Aug 15, 1989 - Jul 31, 1990
    Role: Principal Investigator
    ANTINEOPLASTIC AGENTS FROM BLUE GREEN ALGAE
    NIH/NCI R23CA042850Jul 1, 1986 - Jun 30, 1990
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Via CW, Glukhov E, Costa S, Zimba PV, Moeller PDR, Gerwick WH, Bertin MJ. The Metabolome of a Cyanobacterial Bloom Visualized by MS/MS-Based Molecular Networking Reveals New Neurotoxic Smenamide Analogs (C, D, and E). Front Chem. 2018; 6:316. PMID: 30094232.
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    2. McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat Prod Rep. 2018 Jul 13. PMID: 30003207.
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    3. O'Rourke A, Kremb S, Duggan BM, Sioud S, Kharbatia N, Raji M, Emwas AH, Gerwick WH, Voolstra CR. Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. Molecules. 2018 Jun 18; 23(6). PMID: 29912151.
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    4. Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z. Corrigendum to: "Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons" [Phytochemistry (2018) 150 85-92]. Phytochemistry. 2018 Jun 13. PMID: 29907440.
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    5. Kristoffersen V, Rämä T, Isaksson J, Andersen JH, Gerwick WH, Hansen E. Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group. Mar Drugs. 2018 May 14; 16(5). PMID: 29758007.
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    6. Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module. ACS Chem Biol. 2018 May 08. PMID: 29701944.
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    7. Moss NA, Leao T, Glukhov E, Gerwick L, Gerwick WH. Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria. Methods Enzymol. 2018; 604:3-43. PMID: 29779657.
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    8. Wang J, Zheng J, Huang C, Zhao J, Lin J, Zhou X, Naman CB, Wang N, Gerwick WH, Wang Q, Yan X, Cui W, He S. Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-ß-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3ß. ACS Chem Neurosci. 2018 Apr 10. PMID: 29608860.
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    9. Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z. Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons. Phytochemistry. 2018 Jun; 150:85-92. PMID: 29571149.
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    10. Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH. Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp. J Org Chem. 2018 Mar 16; 83(6):3034-3046. PMID: 29457979.
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    11. Shao CL, Mou XF, Cao F, Spadafora C, Glukhov E, Gerwick L, Wang CY, Gerwick WH. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. J Nat Prod. 2018 Jan 26; 81(1):211-215. PMID: 29327931.
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    12. Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L. Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod. 2018 Mar 23; 81(3):506-514. PMID: 29215273.
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    13. Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem Biol. 2017 12 15; 12(12):3039-3048. PMID: 29096064.
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    14. Zhang C, Idelbayev Y, Roberts N, Tao Y, Nannapaneni Y, Duggan BM, Min J, Lin EC, Gerwick EC, Cottrell GW, Gerwick WH. Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research. Sci Rep. 2017 Oct 27; 7(1):14243. PMID: 29079836.
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    15. Gerwick WH. The Face of a Molecule. J Nat Prod. 2017 Sep 22; 80(9):2583-2588. PMID: 28885833.
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    16. Fang F, Zhao J, Ding L, Huang C, Naman CB, He S, Wu B, Zhu P, Luo Q, Gerwick WH, Yan X, Wang Q, Zhang Z, Cui W. 5-Hydroxycyclopenicillone, a New ß-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34. Mar Drugs. 2017 Aug 19; 15(8). PMID: 28825620.
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    17. Lin J, Yu J, Zhao J, Zhang K, Zheng J, Wang J, Huang C, Zhang J, Yan X, Gerwick WH, Wang Q, Cui W, He S. Fucoxanthin, a Marine Carotenoid, Attenuates ß-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells. Oxid Med Cell Longev. 2017; 2017:6792543. PMID: 28928905.
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    18. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. J Nat Prod. 2017 Aug 25; 80(8):2328-2334. PMID: 28783331.
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    19. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 Aug 10; 60(15):6721-6732. PMID: 28696697.
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    20. Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):E6273. PMID: 28710331.
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    21. Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH. Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 Jun 23; 80(6):1827-1836. PMID: 28535042.
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    22. Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC. Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae. Elife. 2017 05 11; 6. PMID: 28492366.
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    23. Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Retrospective analysis of natural products provides insights for future discovery trends. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):5601-5606. PMID: 28461474.
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    24. Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH. A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod. 2017 May 26; 80(5):1514-1521. PMID: 28448144.
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    25. Zhang C, Naman CB, Engene N, Gerwick WH. Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata. Mar Drugs. 2017 Apr 14; 15(4). PMID: 28420100.
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    26. Dhaneesha M, Benjamin Naman C, Krishnan KP, Sinha RK, Jayesh P, Joseph V, Bright Singh IS, Gerwick WH, Sajeevan TP. Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products. 3 Biotech. 2017 May; 7(1):32. PMID: 28401470.
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    27. Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick WH, Gerwick L. Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3198-3203. PMID: 28265051.
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    28. Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH. Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J Nat Prod. 2017 Mar 24; 80(3):625-633. PMID: 28055219.
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    29. Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP. Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. Angew Chem Int Ed Engl. 2016 Nov 21; 55(48):14895. PMID: 27860179.
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    30. Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase. ACS Chem Biol. 2016 12 16; 11(12):3319-3327. PMID: 27723289.
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    31. Sun P, Yu Q, Li J, Riccio R, Lauro G, Bifulco G, Kurtán T, Mándi A, Tang H, Li TJ, Zhuang CL, Gerwick WH, Zhang W. Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride. J Nat Prod. 2016 10 28; 79(10):2552-2558. PMID: 27704808.
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    32. Sabry OM, Goeger DE, Gerwick WH. Bioactive new metabolites from the green alga Udotea orientalis growing on the Gorgonian coral Pseudopterogorgia rigida. Nat Prod Res. 2017 Jun; 31(11):1245-1250. PMID: 27653761.
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    33. Sabry OM, Goeger DE, Valeriote FA, Gerwick WH. Cytotoxic halogenated monoterpenes from Plocamium cartilagineum. Nat Prod Res. 2017 Feb; 31(3):261-267. PMID: 27627578.
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    34. Cummings SL, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick WH, Gerwick L. A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB. BMC Microbiol. 2016 08 30; 16(1):198. PMID: 27577966; PMCID: PMC5006271.
    35. Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Anatomy of the ß-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10316-21. PMID: 27573844; PMCID: PMC5027445 [Available on 03/13/17].
    36. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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    37. Sabry OM, Goeger DE, Gerwick WH. Biologically active new metabolites from a Florida collection of Moorea producens. Nat Prod Res. 2017 Mar; 31(5):555-561. PMID: 27426414.
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    38. Torres-Mendoza D, González Y, Gómez-Reyes JF, Guzmán HM, López-Perez JL, Gerwick WH, Fernandez PL, Gutiérrez M. Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea. Molecules. 2016 Jun 22; 21(6). PMID: 27338338.
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    39. Videau P, Wells KN, Singh AJ, Gerwick WH, Philmus B. Assessment of Anabaena sp. Strain PCC 7120 as a Heterologous Expression Host for Cyanobacterial Natural Products: Production of Lyngbyatoxin A. ACS Synth Biol. 2016 09 16; 5(9):978-88. PMID: 27176641.
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    40. Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick WH, Parker JE, Schroeder JI. Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants. PLoS One. 2016; 11(5):e0155937. PMID: 27219122; PMCID: PMC4878808.
    41. Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel. Cell Chem Biol. 2016 May 19; 23(5):561-566. PMID: 27203376.
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    42. Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K. Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Mol Cancer Ther. 2016 06; 15(6):1208-16. PMID: 27196783.
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    43. Briand E, Humbert JF, Tambosco K, Bormans M, Gerwick WH. Role of bacteria in the production and degradation of Microcystis cyanopeptides. Microbiologyopen. 2016 06; 5(3):469-78. PMID: 26918405; PMCID: PMC4905998.
    44. O'Rourke A, Kremb S, Bader TM, Helfer M, Schmitt-Kopplin P, Gerwick WH, Brack-Werner R, Voolstra CR. Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1). Mar Drugs. 2016 Feb 04; 14(2). PMID: 26861355; PMCID: PMC4771981.
    45. Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH. Unique marine derived cyanobacterial biosynthetic genes for chemical diversity. Nat Prod Rep. 2016 Feb; 33(2):348-64. PMID: 26758451.
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    46. Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ. Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple ß-Amino Acids. Org Lett. 2016 Feb 05; 18(3):352-5. PMID: 26784681.
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    47. Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH. The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide. Chembiochem. 2016 Jan; 17(2):164-73. PMID: 26769357; PMCID: PMC4878910 [Available on 01/01/17].
    48. Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick WH. Kalkipyrone B, a marine cyanobacterial ?-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. 2016 Feb; 122:113-118. PMID: 26632528; PMCID: PMC4724546 [Available on 02/01/17].
    49. Teta R, Della Sala G, Glukhov E, Gerwick L, Gerwick WH, Mangoni A, Costantino V. Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle. Environ Sci Technol. 2015 Dec 15; 49(24):14301-10. PMID: 26567695; PMCID: PMC4851459 [Available on 12/15/16].
    50. Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick WH. Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery. J Ind Microbiol Biotechnol. 2016 Mar; 43(2-3):313-24. PMID: 26578313.
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    51. Sapkota M, Li L, Choi H, Gerwick WH, Soh Y. Bromo-honaucin A inhibits osteoclastogenic differentiation in RAW 264.7 cells via Akt and ERK signaling pathways. Eur J Pharmacol. 2015 Dec 15; 769:100-9. PMID: 26550952; PMCID: PMC4684412 [Available on 12/15/16].
    52. Khare D, Hale WA, Tripathi A, Gu L, Sherman DH, Gerwick WH, Håkansson K, Smith JL. Structural Basis for Cyclopropanation by a Unique Enoyl-Acyl Carrier Protein Reductase. Structure. 2015 Dec 01; 23(12):2213-2223. PMID: 26526850.
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    53. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Sep; 11(9):625-31. PMID: 26284661.
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    54. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. J Org Chem. 2015 Aug 21; 80(16):7849-55. PMID: 26222145.
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    55. Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP. Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria. Angew Chem Int Ed Engl. 2015 Sep 14; 54(38):11063-7. PMID: 26235728.
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    56. Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH. Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows. PLoS One. 2015; 10(7):e0133297. PMID: 26222584; PMCID: PMC4519256.
    57. Briand E, Bormans M, Gugger M, Dorrestein PC, Gerwick WH. Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions. Environ Microbiol. 2016 Feb; 18(2):384-400. PMID: 25980449.
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    58. Kleigrewe K, Almaliti J, Tian IY, Kinnel RB, Korobeynikov A, Monroe EA, Duggan BM, Di Marzo V, Sherman DH, Dorrestein PC, Gerwick L, Gerwick WH. Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod. 2015 Jul 24; 78(7):1671-82. PMID: 26149623; PMCID: PMC4681511.
    59. Moore BS, Gerwick WH. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. J Nat Prod. 2015 Mar 27; 78(3):347-8. PMID: 25814030.
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    233. Li WI, Berman FW, Okino T, Yokokawa F, Shioiri T, Gerwick WH, Murray TF. Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7599-604. PMID: 11416227; PMCID: PMC34714.
    234. Nogle LM, Williamson RT, Gerwick WH. Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species. J Nat Prod. 2001 Jun; 64(6):716-9. PMID: 11421730.
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    235. Gerwick WH, Tan LT, Sitachitta N. Nitrogen-containing metabolites from marine cyanobacteria. Alkaloids Chem Biol. 2001; 57:75-184. PMID: 11705123.
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    236. Milligan KE, Marquez BL, Williamson RT, Gerwick WH. Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Oct; 63(10):1440-3. PMID: 11076574.
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    237. Tan LT, Okino T, Gerwick WH. Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):952-5. PMID: 10924172.
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    238. Milligan KE, Márquez B, Williamson RT, Davies-Coleman M, Gerwick WH. Two new malyngamides from a Madagascan Lyngbya majuscula. J Nat Prod. 2000 Jul; 63(7):965-8. PMID: 10924175.
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    239. Williamson RT, Carney JR, Gerwick WH. Application of the BIRD sandwich for the rapid and accurate determination of (1)H-(1)H NMR coupling constants in higher order spin systems. J Nat Prod. 2000 Jun; 63(6):876-8. PMID: 10869227.
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    240. Williamson RT, Chapin EL, Carr AW, Gilbert JR, Graupner PR, Lewer P, McKamey P, Carney JR, Gerwick WH. New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures. Org Lett. 2000 Feb 10; 2(3):289-92. PMID: 10814304.
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    241. Sitachitta N, Williamson RT, Gerwick WH. Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. J Nat Prod. 2000 Feb; 63(2):197-200. PMID: 10691708.
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    242. Tan LT, Williamson RT, Gerwick WH, Watts KS, McGough K, Jacobs R. cis,cis- and trans,trans-ceratospongamide, new bioactive cyclic heptapeptides from the Indonesian red alga Ceratodictyon spongiosum and symbiotic sponge Sigmadocia symbiotica. J Org Chem. 2000 Jan 28; 65(2):419-25. PMID: 10813950.
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    243. Jiang ZD, Ketchum SO, Gerwick WH. 5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa. Phytochemistry. 2000 Jan; 53(1):129-33. PMID: 10656420.
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    244. Berman FW, Gerwick WH, Murray TF. Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon. 1999 Nov; 37(11):1645-8. PMID: 10482399.
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    245. Verdier-Pinard P, Sitachitta N, Rossi JV, Sackett DL, Gerwick WH, Hamel E. Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin. Arch Biochem Biophys. 1999 Oct 01; 370(1):51-8. PMID: 10496976.
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    246. Singh IP, Milligan KE, Gerwick WH. Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1999 Sep; 62(9):1333-5. PMID: 10514329.
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    247. Gerwick WH, Roberts MA, Vulpanovici A, Ballantine DL. Biogenesis and biological function of marine algal oxylipins. Adv Exp Med Biol. 1999; 447:211-8. PMID: 10086197.
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    248. Márquez B, Verdier-Pinard P, Hamel E, Gerwick WH. Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. Phytochemistry. 1998 Dec; 49(8):2387-9. PMID: 9887531.
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    249. Bisogno T, Melck D, De Petrocellis L. Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):515-22. PMID: 9703957.
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    250. Graber MA, Gerwick WH. Kalkipyrone, a toxic gamma-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp. J Nat Prod. 1998 May; 61(5):677-80. PMID: 9599278.
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    251. Sitachitta N, Gerwick WH. Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 May; 61(5):681-4. PMID: 9599279.
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    252. Hooper GJ, Orjala J, Schatzman RC, Gerwick WH. Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1998 Apr; 61(4):529-33. PMID: 9584405.
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    253. Verdier-Pinard P, Lai JY, Yoo HD, Yu J, Marquez B, Nagle DG, Nambu M, White JD, Falck JR, Gerwick WH, Day BW, Hamel E. Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol. 1998 Jan; 53(1):62-76. PMID: 9443933.
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    254. Orjala J, Gerwick WH. Two quinoline alkaloids from the Caribbean cyanobacterium Lyngbya majuscula. Phytochemistry. 1997 Jul; 45(5):1087-90. PMID: 9214778.
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    255. Wise ML, Rossi J, Gerwick WH. Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina. Biochemistry. 1997 Mar 11; 36(10):2985-92. PMID: 9062129.
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    256. Jiang ZD, Gerwick WH. Novel oxylipins from the temperate red alga Polyneura latissima: evidence for an arachidonate 9(S)-lipoxygenase. Lipids. 1997 Mar; 32(3):231-5. PMID: 9076659.
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    257. Gerwick WH, Wise ML, Soderstrom K, Murray TF. Biosynthesis and cannabinoid receptor affinity of the novel eicosanoid, conjugated triene anandamide. Adv Exp Med Biol. 1997; 407:329-34. PMID: 9321972.
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    258. Gerwick WH. Epoxy allylic carbocations as conceptual intermediates in the biogenesis of diverse marine oxylipins. Lipids. 1996 Dec; 31(12):1215-31. PMID: 8972454.
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    259. Orjala J, Gerwick WH. Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1996 Apr; 59(4):427-30. PMID: 8699186.
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    260. Wise ML, Soderstrom K, Murray TF, Gerwick WH. Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid. Experientia. 1996 Jan 16; 52(1):88-92. PMID: 8575565.
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    261. Blokhin AV, Yoo HD, Geralds RS, Nagle DG, Gerwick WH, Hamel E. Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. Mol Pharmacol. 1995 Sep; 48(3):523-31. PMID: 7565634.
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    262. Mikhailova MV, Bemis DL, Wise ML, Gerwick WH, Norris JN, Jacobs RS. Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata. Lipids. 1995 Jul; 30(7):583-9. PMID: 7564911.
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    263. Orjala J, Nagle D, Gerwick WH. Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 May; 58(5):764-8. PMID: 7623050.
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    264. Todd JS, Gerwick WH. Isolation of a cyclic carbonate, a gamma-butyrolactone, and a new indole derivative from the marine cyanobacterium Lyngbya majuscula. J Nat Prod. 1995 Apr; 58(4):586-9. PMID: 7623035.
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    265. Wise ML, Hamberg M, Gerwick WH. Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina. Biochemistry. 1994 Dec 27; 33(51):15223-32. PMID: 7803384.
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    266. Proteau PJ, Rossi JV, Gerwick WH. Absolute stereochemistry of neohalicholactone from the brown alga Laminaria sinclairii. J Nat Prod. 1994 Dec; 57(12):1717-9. PMID: 7714540.
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    267. Chen JL, Gerwick WH, Schatzman R, Laney M. Isorawsonol and related IMP dehydrogenase inhibitors from the tropical green alga Avrainvillea rawsonii. J Nat Prod. 1994 Jul; 57(7):947-52. PMID: 7964790.
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    268. Chen JL, Proteau PJ, Roberts MA, Gerwick WH, Slate DL, Lee RH. Structure of malhamensilipin A, an inhibitor of protein tyrosine kinase, from the cultured chrysophyte Poterioochromonas malhamensis. J Nat Prod. 1994 Apr; 57(4):524-7. PMID: 8021653.
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    269. Gerwick WH. Structure and biosynthesis of marine algal oxylipins. Biochim Biophys Acta. 1994 Mar 24; 1211(3):243-55. PMID: 8130256.
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    270. Todd JS, Proteau PJ, Gerwick WH. The absolute configuration of ecklonialactones A, B, and E, novel oxylipins from brown algae of the genera Ecklonia and Egregia. J Nat Prod. 1994 Jan; 57(1):171-4. PMID: 8158161.
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    271. Proteau PJ, Gerwick WH, Garcia-Pichel F, Castenholz R. The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria. Experientia. 1993 Sep 15; 49(9):825-9. PMID: 8405307.
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    272. Proteau PJ, Gerwick WH. Divinyl ethers and hydroxy fatty acids from three species of Laminaria (brown algae). Lipids. 1993 Sep; 28(9):783-7. PMID: 8231653.
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    273. Hamberg M, Gerwick WH. Biosynthesis of vicinal dihydroxy fatty acids in the red alga Gracilariopsis lemaneiformis: identification of a sodium-dependent 12-lipoxygenase and a hydroperoxide isomerase. Arch Biochem Biophys. 1993 Aug 15; 305(1):115-22. PMID: 8342944.
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    274. Bernart MW, Whatley GG, Gerwick WH. Unprecedented oxylipins from the marine green alga Acrosiphonia coalita. J Nat Prod. 1993 Feb; 56(2):245-59. PMID: 8463797.
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    275. Nagle DG, McClatchey WC, Gerwick WH. New glycosphingolipids from the marine sponge Halichondria panicea. J Nat Prod. 1992 Jul; 55(7):1013-7. PMID: 1402953.
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    276. Moghaddam MF, Gerwick WH. Cell-free biosynthesis and source of hydroxyl groups in (12R,13S)-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid, a novel eicosanoid from the marine alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Nov-Dec; 54(6):1619-24. PMID: 1667411.
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    277. Gerwick WH, Moghaddam M, Hamberg M. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. Arch Biochem Biophys. 1991 Nov 01; 290(2):436-44. PMID: 1929410.
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    278. Jiang ZD, Gerwick WH. An aldehyde-containing galactolipid from the red alga Gracilariopsis lemaneiformis. Lipids. 1991 Nov; 26(11):960-3. PMID: 1805099.
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    279. Jiang ZD, Gerwick WH. Novel pyrroles from the Oregon red alga Gracilariopsis lemaneiformis. J Nat Prod. 1991 Mar-Apr; 54(2):403-7. PMID: 1919587.
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    280. Moghaddam MF, Gerwick WH, Ballantine DL. Discovery of the mammalian insulin release modulator, hepoxilin B3, from the tropical red algae Platysiphonia miniata and Cottoniella filamentosa. J Biol Chem. 1990 Apr 15; 265(11):6126-30. PMID: 2180942.
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    281. Solem ML, Jiang ZD, Gerwick WH. Three new and bioactive icosanoids from the temperate red marine alga Farlowia mollis. Lipids. 1989 Apr; 24(4):256-60. PMID: 2547132.
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    282. Gerwick WH. 6-Desmethoxyhormothamnione, a new cytotoxic styrylchromone from the marine cryptophyte Chrysophaeum taylori. J Nat Prod. 1989 Mar-Apr; 52(2):252-6. PMID: 2746254.
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    283. Gerwick WH, Mrozek C, Moghaddam MF, Agarwal SK. Novel cytotoxic peptides from the tropical marine cyanobacterium Hormothamnion enteromorphoides. 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured material. Experientia. 1989 Feb 15; 45(2):115-21. PMID: 2493387.
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    284. Gerwick WH, Whatley G. Aplysia sea hare assimilation of secondary metabolites from brown seaweed,Stypopodium zonale. J Chem Ecol. 1989 Feb; 15(2):677-83. PMID: 24271808.
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    285. Moghaddam MF, Gerwick WH, Ballantine DL. Discovery of 12-(S)-hydroxy-5,8,10,14-icosatetraenoic acid [12-(S)-HETE] in the tropical red alga Platysiphonia miniata. Prostaglandins. 1989 Feb; 37(2):303-8. PMID: 2727309.
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    286. Stennett DJ, Gerwick WH, Egging PK, Christensen JM. Precipitate analysis from an indwelling total parenteral nutrition catheter. JPEN J Parenter Enteral Nutr. 1988 Jan-Feb; 12(1):88-92. PMID: 3125364.
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    287. Colon M, Guevara P, Gerwick WH, Ballantine D. 5'-Hydroxyisoavrainvilleol, a new diphenylmethane derivative from the tropical green alga Avrainvillea nigricans. J Nat Prod. 1987 May-Jun; 50(3):368-74. PMID: 3668556.
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    288. Lopez A, Gerwick WH. Two new icosapentaenoic acids from the temperate red seaweed Ptilota filicina J. Agardh. Lipids. 1987 Mar; 22(3):190-4. PMID: 3033420.
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