Vivian Hook

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of California, San Francisco

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Development of molecular probe inhibitors of pathogenic, cytosolic cathespin B in traumatic brain injury and Alzheimers Disease neurodegeneration
    NIH/NINDS R01NS109075Aug 1, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Role of Human-Specific Cathepsin V Protease in the Production of Opioid and Related Peptide Neurotransmitters
    NIH/NINDS R01NS094597Feb 15, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Dynorphin Antisense Oligonucleotides for Alleviation of Chronic Pain without Addiction
    NIH/NIDA R21DA044515Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
    NIH R56AG057469Sep 15, 2017 - Aug 31, 2019
    Role: Co-Principal Investigator
    Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    NIH/NIA R21AG042828Jul 1, 2013 - Apr 30, 2015
    Role: Principal Investigator
    Huntington's Disease Natural Product Drug Discovery
    NIH R21AG038772Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Proteolytic Fragments of Mutant Huntingtin Protein in HD Brain Regions
    NIH/NINDS R21NS063064Jun 1, 2010 - May 31, 2013
    Role: Principal Investigator
    POMC Processing and Beta-Endorphine-Related Opioid Peptides
    NIH/NIMH R01MH077305May 15, 2006 - Apr 30, 2013
    Role: Principal Investigator
    Proteomics/Genomics of Opiate Analgesia and Addiction
    NIH/NIDA R21DA015532Aug 1, 2003 - May 31, 2006
    Role: Principal Investigator
    Integrated DNA Sequencing System
    NIH/NCRR S10RR016614Jul 15, 2002 - May 31, 2004
    Role: Principal Investigator
    Training in Neuroscience Related to Drug Abuse
    NIH/NIDA T32DA007315Jul 1, 2000 - Jun 30, 2014
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    NIH/NIDA R01DA008825Jun 1, 1996 - Oct 14, 2000
    Role: Principal Investigator
    NIH/NIDA K02DA000228Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator
    Serpin Protease Inhibitors &Opioid Neuropeptides
    NIH/NINDS R01NS024553Apr 1, 1987 - Oct 14, 2000
    Role: Principal Investigator
    Biosynthesis of Enkephalin Opioid Peptides
    NIH/NIDA R01DA004271Jan 1, 1987 - Oct 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    2. Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. J Am Soc Mass Spectrom. 2018 05; 29(5):807-816. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. PMID: 29667161; PMCID: PMC5946320.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    3. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478; PMCID: PMC4902163.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    4. Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. J Am Soc Mass Spectrom. 2015 Dec; 26(12):1970-80. Hook V, Bandeira N. PMID: 26483184; PMCID: PMC4749436.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    5. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. PMID: 25358781; PMCID: PMC4223699.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    6. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012 Jan; 1824(1):89-104. Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. PMID: 21925292; PMCID: PMC3232284.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    7. Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. AAPS J. 2010 Dec; 12(4):635-45. Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. PMID: 20734175; PMCID: PMC2976990.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    8. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biol Chem. 2010 Aug; 391(8):861-72. Hook V, Hook G, Kindy M. PMID: 20536395; PMCID: PMC4309269.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    9. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21; 386(2):284-8. Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. PMID: 19501042; PMCID: PMC2753505.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    10. Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 2009 Jun; 35(3):429-37. Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. PMID: 19343278; PMCID: PMC2731682.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    11. Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biol Chem. 2008 Aug; 389(8):993-1006. Hook V, Schechter I, Demuth HU, Hook G. PMID: 18979625; PMCID: PMC2654319.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    12. Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells. Neuropeptides. 2008 Oct-Dec; 42(5-6):503-11. Hook V, Toneff T, Baylon S, Sei C. PMID: 18619673; PMCID: PMC2745396.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    13. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. J Biol Chem. 2008 Mar 21; 283(12):7745-53. Hook VY, Kindy M, Hook G. PMID: 18184658.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    14. Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu Rev Pharmacol Toxicol. 2008; 48:393-423. Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. PMID: 18184105; PMCID: PMC2731677.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimals
    15. Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biol Chem. 2007 Feb; 388(2):247-52. Hook V, Kindy M, Hook G. PMID: 17261088.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    16. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biol Chem. 2006 Oct-Nov; 387(10-11):1429-39. Hook VY. PMID: 17081116.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):449-69. Hook VY. PMID: 16724274.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005 Sep; 386(9):931-40. Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. PMID: 16164418.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    19. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun; 385(6):473-80. Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. PMID: 15255178.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells. Endocrinology. 1999 Aug; 140(8):3744-54. Hook VY, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH. PMID: 10433235.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J Biol Chem. 1999 Jan 29; 274(5):3165-72. Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. PMID: 9915856.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing. Protein Expr Purif. 1997 Jun; 10(1):80-8. Hook VY, Moran K, Kannan R, Kohn A, Lively MO, Azaryan A, Schiller M, Miller K. PMID: 9179294.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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