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Vivian Hook

TitleAdjunct Professor
InstitutionUniversity of California San Diego
DepartmentNeurosciences
Address9500 Gilman Drive #0657
La Jolla CA 92093
Phone858-822-6682
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    Collapse Biography 
    Collapse Education and Training
    Ph.D.University of California, San Francisco

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Dynorphin Antisense Oligonucleotides for Alleviation of Chronic Pain without Addiction
    NIH/NIDA R21DA044515Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
    NIH/NIA R56AG057469Sep 15, 2017 - Aug 31, 2018
    Role: Co-Principal Investigator
    Role of Human-Specific Cathepsin V Protease in the Production of Opioid and Related Peptide Neurotransmitters
    NIH/NINDS R01NS094597Sep 30, 2015 - Jul 31, 2019
    Role: Principal Investigator
    Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
    NIH/NIA R21AG042828Jul 1, 2013 - Apr 30, 2015
    Role: Principal Investigator
    Huntington's Disease Natural Product Drug Discovery
    NIH/NIA R21AG038772Sep 1, 2011 - Aug 31, 2014
    Role: Principal Investigator
    Proteolytic Fragments of Mutant Huntingtin Protein in HD Brain Regions
    NIH/NINDS R21NS063064Jun 1, 2010 - May 31, 2013
    Role: Principal Investigator
    POMC Processing and Beta-Endorphine-Related Opioid Peptides
    NIH/NIMH R01MH077305May 15, 2006 - Apr 30, 2013
    Role: Principal Investigator
    Proteomics/Genomics of Opiate Analgesia and Addiction
    NIH/NIDA R21DA015532Aug 1, 2003 - May 31, 2006
    Role: Principal Investigator
    Integrated DNA Sequencing System
    NIH/NCRR S10RR016614Jul 15, 2002 - Jul 14, 2005
    Role: Principal Investigator
    Training in Neuroscience Related to Drug Abuse
    NIH/NIDA T32DA007315Jul 1, 2000 - Jun 30, 2014
    Role: Principal Investigator
    Sympathetic Neuroeffector Junctions &Blood Pressure
    NIH P01HL058120Jun 1, 1999 - May 31, 2012
    Role: Co-Investigator
    POMC PROCESSING &BETA-ENDORPHIN RELATED OPIOID PEPTIDE
    NIH/NIDA R01DA008825Jun 1, 1996 - Dec 31, 2003
    Role: Principal Investigator
    OPIATE PRECURSOR PROCESSING
    NIH/NIDA K02DA000228Apr 1, 1995 - Mar 31, 2000
    Role: Principal Investigator
    Serpin Protease Inhibitors &Opioid Neuropeptides
    NIH/NINDS R01NS024553Apr 1, 1987 - Jun 30, 2010
    Role: Principal Investigator
    Biosynthesis of Enkephalin Opioid Peptides
    NIH/NIDA R01DA004271Jan 1, 1987 - May 31, 2010
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hsu A, Podvin S, Hook V. Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development. J Mol Neurosci. 2018 Jul 14. PMID: 30008074.
      View in: PubMed
    2. Podvin S, Wojnicz A, Hook V. Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon. 2018 Jul; 4(7):e00673. PMID: 29998195.
      View in: PubMed
    3. Podvin S, Reardon HT, Yin K, Mosier C, Hook V. Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2018 Jun 28. PMID: 29956026.
      View in: PubMed
    4. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. J Am Soc Mass Spectrom. 2018 May; 29(5):807-816. PMID: 29667161.
      View in: PubMed
    5. Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 Mar 19. PMID: 29556927.
      View in: PubMed
    6. Benyamin B, Maihofer AX, Schork AJ, Hamilton BA, Rao F, Schmid-Schönbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook V, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. Identification of novel loci affecting circulating chromogranins and related peptides. Hum Mol Genet. 2017 01 01; 26(1):233-242. PMID: 28011710.
      View in: PubMed
    7. Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook V, Garg N, Hoffner N, Jiang Y, Kapono CA, Koester I, Knight R, Leber CA, Ling TJ, Luzzatto-Knaan T, McCall LI, McGrath AP, Meehan MJ, Merritt JK, Mills RH, Morton J, Podvin S, Protsyuk I, Purdy T, Satterfield K, Searles S, Shah S, Shires S, Steffen D, White M, Todoric J, Tuttle R, Wojnicz A, Sapp V, Vargas F, Yang J, Zhang C, Dorrestein PC. Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem. 2016 Nov 15; 88(22):10775-10784. PMID: 27732780.
      View in: PubMed
    8. Podvin S, Yaksh T, Hook V. The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. PMID: 26738478; PMCID: PMC4902163 [Available on 01/01/17].
    9. Hook V, Bandeira N. Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. J Am Soc Mass Spectrom. 2015 Dec; 26(12):1970-80. PMID: 26483184; PMCID: PMC4749436 [Available on 12/01/16].
    10. Hook G, Jacobsen JS, Grabstein K, Kindy M, Hook V. Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Front Neurol. 2015; 6:178. PMID: 26388830; PMCID: PMC4557097.
    11. Podvin S, Bundey R, Toneff T, Ziegler M, Hook V. Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Mol Cell Neurosci. 2015 Sep; 68:177-85. PMID: 26092702; PMCID: PMC4593749.
    12. Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. PMID: 25358781; PMCID: PMC4223699.
    13. Cynis H, Funkelstein L, Toneff T, Mosier C, Ziegler M, Koch B, Demuth HU, Hook V. Pyroglutamate-amyloid-ß and glutaminyl cyclase are colocalized with amyloid-ß in secretory vesicles and undergo activity-dependent, regulated secretion. Neurodegener Dis. 2014; 14(2):85-97. PMID: 24943989; PMCID: PMC4141002.
    14. Hook GR, Yu J, Sipes N, Pierschbacher MD, Hook V, Kindy MS. The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury. J Neurotrauma. 2014 Mar 01; 31(5):515-29. PMID: 24083575; PMCID: PMC3934599.
    15. Suhy A, Hartmann K, Newman L, Papp A, Toneff T, Hook V, Sadee W. Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein. Biochem Biophys Res Commun. 2014 Jan 24; 443(4):1270-4. PMID: 24393849; PMCID: PMC3929938.
    16. Hook G, Yu J, Toneff T, Kindy M, Hook V. Brain pyroglutamate amyloid-ß is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. J Alzheimers Dis. 2014; 41(1):129-49. PMID: 24595198; PMCID: PMC4059604.
    17. Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod. 2014 Jan 24; 77(1):92-9. PMID: 24364476; PMCID: PMC3932306.
    18. Zhang K, Biswas N, Gayen JR, Miramontes-Gonzalez JP, Hightower CM, Mustapic M, Mahata M, Huang CT, Hook V, Mahata SK, Vaingankar S, O'Connor DT. Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms. J Neurochem. 2014 Apr; 129(1):48-59. PMID: 24266713; PMCID: PMC3992281.
    19. Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 2013 Aug; 46:126-35. PMID: 23747840; PMCID: PMC3842158.
    20. Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V. Spinal astrocytes produce and secrete dynorphin neuropeptides. Neuropeptides. 2013 Apr; 47(2):109-15. PMID: 23290538; PMCID: PMC3606903.
    21. Mbewe-Campbell N, Wei Z, Zhang K, Friese RS, Mahata M, Schork AJ, Rao F, Chiron S, Biswas N, Kim HS, Mahata SK, Waalen J, Nievergelt CM, Hook V, O'Connor DT. Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure. J Hypertens. 2012 Oct; 30(10):1961-9. PMID: 22871890; PMCID: PMC3478326.
    22. Bark SJ, Wegrzyn J, Taupenot L, Ziegler M, O'Connor DT, Ma Q, Smoot M, Ideker T, Hook V. The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases. PLoS One. 2012; 7(8):e41134. PMID: 22916103; PMCID: PMC3420874.
    23. Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. J Neurochem. 2012 Aug; 122(3):512-22. PMID: 22582844; PMCID: PMC3417130.
    24. Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. J Biol Chem. 2012 May 04; 287(19):15232-41. PMID: 22393040; PMCID: PMC3346103.
    25. Lu WD, Liu T, Li S, Woods VL, Hook V. The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Sci. 2012 Feb; 21(2):178-87. PMID: 22102294; PMCID: PMC3324762.
    26. Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook GR. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AßPP containing the wild-type ß-secretase site sequence. J Alzheimers Dis. 2012; 29(4):827-40. PMID: 22337825; PMCID: PMC4309289.
    27. Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012 Jan; 1824(1):89-104. PMID: 21925292; PMCID: PMC3232284.
    28. Kim Y, Bark S, Hook V, Bandeira N. NeuroPedia: neuropeptide database and spectral library. Bioinformatics. 2011 Oct 01; 27(19):2772-3. PMID: 21821666; PMCID: PMC3179654.
    29. Zhang L, Yun H, Murray F, Lu R, Wang L, Hook V, Insel PA. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cell Signal. 2011 Oct; 23(10):1611-6. PMID: 21620962; PMCID: PMC3148345.
    30. Pham VL, Gouzy-Darmon C, Pernier J, Hanquez C, Hook V, Beinfeld MC, Nicolas P, Etchebest C, Foulon T, Cadel S. Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties. Biochimie. 2011 Apr; 93(4):730-41. PMID: 21237246.
      View in: PubMed
    31. Funkelstein L, Hook V. The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression. Methods Mol Biol. 2011; 768:107-25. PMID: 21805239.
      View in: PubMed
    32. Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-ß and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, ß-secretase activity. J Alzheimers Dis. 2011; 26(2):387-408. PMID: 21613740; PMCID: PMC4317342.
    33. Funkelstein L, Beinfeld M, Minokadeh A, Zadina J, Hook V. Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides. Neuropeptides. 2010 Dec; 44(6):457-66. PMID: 21047684; PMCID: PMC3058267.
    34. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook V, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160; PMCID: PMC3008929.
    35. Gupta N, Bark SJ, Lu WD, Taupenot L, O'Connor DT, Pevzner P, Hook V. Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing. J Proteome Res. 2010 Oct 01; 9(10):5065-75. PMID: 20704348; PMCID: PMC3000314.
    36. Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. PMID: 20695487; PMCID: PMC2996463.
    37. Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. AAPS J. 2010 Dec; 12(4):635-45. PMID: 20734175; PMCID: PMC2976990.
    38. Hook V, Hook G, Kindy M. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biol Chem. 2010 Aug; 391(8):861-72. PMID: 20536395; PMCID: PMC4309269.
    39. Chakrabarti L, Zahra R, Jackson SM, Kazemi-Esfarjani P, Sopher BL, Mason AG, Toneff T, Ryu S, Shaffer S, Kansy JW, Eng J, Merrihew G, MacCoss MJ, Murphy A, Goodlett DR, Hook V, Bennett CL, Pallanck LJ, La Spada AR. Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration mice reveals a role for Nna proteins in neuronal bioenergetics. Neuron. 2010 Jun 24; 66(6):835-47. PMID: 20620870; PMCID: PMC3101252.
    40. Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE, Bark S, Dorrestein PC. Expansion of the mycobacterial "PUPylome". Mol Biosyst. 2010 Feb; 6(2):376-85. PMID: 20094657.
      View in: PubMed
    41. Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Mol Cell Neurosci. 2010 Jan; 43(1):98-107. PMID: 19837164.
      View in: PubMed
    42. Lortie M, Bark S, Blantz R, Hook V. Detecting low-abundance vasoactive peptides in plasma: progress toward absolute quantitation using nano liquid chromatography-mass spectrometry. Anal Biochem. 2009 Nov 15; 394(2):164-70. PMID: 19615967; PMCID: PMC2745394.
    43. Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 2009 Oct; 30(10):1882-91. PMID: 19589362; PMCID: PMC2755599.
    44. Lee JC, Hook V. Proteolytic fragments of chromogranins A and B represent major soluble components of chromaffin granules, illustrated by two-dimensional proteomics with NH(2)-terminal Edman peptide sequencing and MALDI-TOF MS. Biochemistry. 2009 Jun 16; 48(23):5254-62. PMID: 19405523; PMCID: PMC2731693.
    45. Hook V, Kindy M, Reinheckel T, Peters C, Hook G. Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21; 386(2):284-8. PMID: 19501042; PMCID: PMC2753505.
    46. Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 2009 Jun; 35(3):429-37. PMID: 19343278; PMCID: PMC2731682.
    47. Bark SJ, Lu WD, Hook V. Linear and accurate quantitation of proenkephalin-derived peptides by isotopic labeling with internal standards and mass spectrometry. Anal Biochem. 2009 Jun 01; 389(1):18-26. PMID: 19289094; PMCID: PMC2731681.
    48. Lu WD, Asmus K, Hwang SR, Li S, Woods VL, Hook V. Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry. 2009 Feb 24; 48(7):1604-12. PMID: 19173595; PMCID: PMC2752437.
    49. Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. J Biol Chem. 2008 Dec 19; 283(51):35652-9. PMID: 18849346; PMCID: PMC2602888.
    50. Hwang SR, Bundey R, Toneff T, Hook V. Endopin serpin protease inhibitors localize with neuropeptides in secretory vesicles and neuroendocrine tissues. Neuroendocrinology. 2009; 89(2):210-6. PMID: 18840998; PMCID: PMC2731708.
    51. Hook V, Schechter I, Demuth HU, Hook G. Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biol Chem. 2008 Aug; 389(8):993-1006. PMID: 18979625; PMCID: PMC2654319.
    52. Hook V, Toneff T, Baylon S, Sei C. Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells. Neuropeptides. 2008 Oct-Dec; 42(5-6):503-11. PMID: 18619673; PMCID: PMC2745396.
    53. Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. J Neurochem. 2008 Jul; 106(1):384-91. PMID: 18410501; PMCID: PMC2661760.
    54. Hwang SR, Hook V. Zinc regulation of aminopeptidase B involved in neuropeptide production. FEBS Lett. 2008 Jul 23; 582(17):2527-31. PMID: 18571504; PMCID: PMC2764277.
    55. Wegrzyn JL, Drudge TM, Valafar F, Hook V. Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites. BMC Bioinformatics. 2008 May 08; 9:232. PMID: 18466625; PMCID: PMC2396638.
    56. Courel M, Vasquez MS, Hook V, Mahata SK, Taupenot L. Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains. J Biol Chem. 2008 Apr 25; 283(17):11807-22. PMID: 18299326; PMCID: PMC2431052.
    57. Hook V, Kindy M, Hook G. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. J Biol Chem. 2008 Mar 21; 283(12):7745-53. PMID: 18184658.
      View in: PubMed
    58. Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu Rev Pharmacol Toxicol. 2008; 48:393-423. PMID: 18184105; PMCID: PMC2731677.
    59. Bark SJ, Hook V. Differential recovery of peptides from sample tubes and the reproducibility of quantitative proteomic data. J Proteome Res. 2007 Nov; 6(11):4511-6. PMID: 17850064.
      View in: PubMed
    60. Hook G, Hook V, Kindy M. Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics. Biol Chem. 2007 Sep; 388(9):979-83. PMID: 17696783.
      View in: PubMed
    61. Wegrzyn J, Lee J, Neveu JM, Lane WS, Hook V. Proteomics of neuroendocrine secretory vesicles reveal distinct functional systems for biosynthesis and exocytosis of peptide hormones and neurotransmitters. J Proteome Res. 2007 May; 6(5):1652-65. PMID: 17408250.
      View in: PubMed
    62. Hwang SR, Hook V. Multiple domains of endopin 2A for serpin cross-class inhibition of papain. Arch Biochem Biophys. 2007 May 15; 461(2):219-24. PMID: 17451636; PMCID: PMC2745395.
    63. Hook V, Kindy M, Hook G. Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biol Chem. 2007 Feb; 388(2):247-52. PMID: 17261088.
      View in: PubMed
    64. Hwang SR, Garza C, Mosier C, Toneff T, Wunderlich E, Goldsmith P, Hook V. Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. J Biol Chem. 2007 Mar 30; 282(13):9556-63. PMID: 17244622.
      View in: PubMed
    65. Hwang SR, O'Neill A, Bark S, Foulon T, Hook V. Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin- and NPY-containing chromaffin granules. J Neurochem. 2007 Mar; 100(5):1340-50. PMID: 17241125.
      View in: PubMed
    66. O'Connor DT, Mahata SK, Mahata M, Jiang Q, Hook V, Taupenot L. Primary culture of bovine chromaffin cells. Nat Protoc. 2007; 2(5):1248-53. PMID: 17546020; PMCID: PMC2715561.
    67. Bark SJ, Hook V. The future of proteomic analysis in biological systems and molecular medicine. Mol Biosyst. 2007 Jan; 3(1):14-7. PMID: 17216050.
      View in: PubMed
    68. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton BA, Hook V, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. PMID: 17026486.
      View in: PubMed
    69. Hook V. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biol Chem. 2006 Oct-Nov; 387(10-11):1429-39. PMID: 17081116.
      View in: PubMed
    70. Hook V. Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):449-69. PMID: 16724274.
      View in: PubMed
    71. Hwang SR, Stoka V, Turk V, Hook V. Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity. Biochem Biophys Res Commun. 2006 Feb 24; 340(4):1238-43. PMID: 16414353.
      View in: PubMed
    72. Hook V. Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research. BioDrugs. 2006; 20(2):105-19. PMID: 16626168.
      View in: PubMed
    73. Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005 Sep; 386(9):931-40. PMID: 16164418.
      View in: PubMed
    74. Hwang SR, Stoka V, Turk V, Hook V. The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition. Biochemistry. 2005 May 31; 44(21):7757-67. PMID: 15909990.
      View in: PubMed
    75. Hwang SR, Garza CZ, Wegrzyn JL, Hook V. Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2. Biochem Biophys Res Commun. 2005 Feb 18; 327(3):837-44. PMID: 15649421.
      View in: PubMed
    76. Hwang SR, Garza CZ, Wegrzyn J, Hook V. Demonstration of GTG as an endogenous initiation codon for a human mRNA transcript revealed by molecular cloning of the serpin endopin 2B. J Biol Chem. 2004 Aug 16. PMID: 15316004.
      View in: PubMed
    77. Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun; 385(6):473-80. PMID: 15255178.
      View in: PubMed
    78. Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ. 2004 Apr; 11(4):424-38. PMID: 14713958.
      View in: PubMed
    79. Hook V, Reisine TD. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway. J Neurosci Res. 2003 Nov 01; 74(3):393-405. PMID: 14598316.
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    80. Miller R, Aaron W, Toneff T, Vishnuvardhan D, Beinfeld MC, Hook V. Obliteration of alpha-melanocyte-stimulating hormone derived from POMC in pituitary and brains of PC2-deficient mice. J Neurochem. 2003 Aug; 86(3):556-63. PMID: 12859669.
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    81. Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9590-5. PMID: 12869695; PMCID: PMC170962.
    82. Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook V. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 2003 Jun 17; 42(23):6938-46. PMID: 12795588.
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    83. Miller R, Toneff T, Vishnuvardhan D, Beinfeld M, Hook V. Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice. Neuropeptides. 2003 Jun; 37(3):140-8. PMID: 12860111.
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    84. Sei C, Toneff T, Aaron W, Hook V. Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH. Peptides. 2003 May; 24(5):717-25. PMID: 12895658.
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    85. Hook V, Metz-Boutigue MH. Protein trafficking to chromaffin granules and proteolytic processing within regulated secretory vesicles of neuroendocrine chromaffin cells. Ann N Y Acad Sci. 2002 Oct; 971:397-405. PMID: 12438158.
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    86. Hook V, Yasothornsrikul S, Hwang SR. Novel chromaffin granule serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities. Ann N Y Acad Sci. 2002 Oct; 971:426-44. PMID: 12438161.
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    87. Bundey RA, Toneff T, Pottenger J, Kennedy BP, Ziegler MG, Hook V. Agonist-stimulated neuropeptide and catecholamine release from bovine adrenal chromaffin cells. Ann N Y Acad Sci. 2002 Oct; 971:338-40. PMID: 12438146.
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    88. Hwang SR, Steineckert B, Toneff T, Bundey R, Logvinova AV, Goldsmith P, Hook V. The novel serpin endopin 2 demonstrates cross-class inhibition of papain and elastase: localization of endopin 2 to regulated secretory vesicles of neuroendocrine chromaffin cells. Biochemistry. 2002 Aug 20; 41(33):10397-405. PMID: 12173926.
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    89. Sei C, Toneff T, Aaron W, Hook V. Regulation of cellular alpha-MSH and beta-endorphin during stimulated secretion from intermediate pituitary cells: involvement of aspartyl and cysteine proteases in the control of cellular levels of alpha-MSH and beta-endorphin. Peptides. 2002 Aug; 23(8):1409-18. PMID: 12182941.
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    90. Toneff T, Mende-Mueller L, Wu Y, Hwang SR, Bundey R, Thompson LM, Chesselet MF, Hook V. Comparison of huntingtin proteolytic fragments in human lymphoblast cell lines and human brain. J Neurochem. 2002 Jul; 82(1):84-92. PMID: 12091468.
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    91. Hook V, Hwang SR. Novel secretory vesicle serpins, endopin 1 and endopin 2: endogenous protease inhibitors with distinct target protease specificities. Biol Chem. 2002 Jul-Aug; 383(7-8):1067-74. PMID: 12437089.
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    92. Hook V, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles. J Neurochem. 2002 Apr; 81(2):237-56. PMID: 12064471.
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    93. Hook V, Burton D, Yasothornsrikul S, Hastings RH, Deftos LJ. Proteolysis of ProPTHrP(1-141) by "prohormone thiol protease" at multibasic residues generates PTHrP-related peptides: implications for PTHrP peptide production in lung cancer cells. Biochem Biophys Res Commun. 2001 Jul 27; 285(4):932-8. PMID: 11467841.
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    94. Deftos LJ, Burton D, Hastings RH, Terkeltaub R, Hook V. Comparative tissue distribution of the processing enzymes "prohormone thiol protease," and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues. Endocrine. 2001 Jul; 15(2):217-24. PMID: 11720250.
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    95. Mende-Mueller LM, Toneff T, Hwang SR, Chesselet MF, Hook V. Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum. J Neurosci. 2001 Mar 15; 21(6):1830-7. PMID: 11245667.
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    96. Hwang SR, Steineckert B, Hook V. Expression and mutagenesis of the novel serpin endopin 2 demonstrates a requirement for cysteine-374 for dithiothreitol-sensitive inhibition of elastase. Biochemistry. 2000 Aug 01; 39(30):8944-52. PMID: 10913307.
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    97. Taylor CV, Taupenot L, Mahata SK, Mahata M, Wu H, Yasothornsrikul S, Toneff T, Caporale C, Jiang Q, Parmer RJ, Hook V, O'Connor DT. Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules. J Biol Chem. 2000 Jul 28; 275(30):22905-15. PMID: 10781584.
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    98. Hwang SR, Ng SM, Steineckert B, Seidah NG, Hook V. Molecular cloning demonstrates structural features of homologous bovine prohormone convertases 1 and 2. DNA Cell Biol. 2000 Jul; 19(7):409-19. PMID: 10945231.
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    99. Yasothornsrikul S, Hook V. Detection of proteolytic activity by fluorescent zymogram in-gel assays. Biotechniques. 2000 Jun; 28(6):1166-8, 1170, 1172-3. PMID: 10868282.
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    100. O'Connor DT, Insel PA, Ziegler MG, Hook V, Smith DW, Hamilton BA, Taylor PW, Parmer RJ. Heredity and the autonomic nervous system in human hypertension. Curr Hypertens Rep. 2000 Feb; 2(1):16-22. PMID: 10982526.
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    101. Hwang SR, Steineckert B, Yasothornsrikul S, Sei CA, Toneff T, Rattan J, Hook V. Molecular cloning of endopin 1, a novel serpin localized to neurosecretory vesicles of chromaffin cells. Inhibition of basic residue-cleaving proteases by endopin 1. J Biol Chem. 1999 Nov 26; 274(48):34164-73. PMID: 10567388.
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    102. Hook V, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH. Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells. Endocrinology. 1999 Aug; 140(8):3744-54. PMID: 10433235.
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    103. Hook V, Tezapsidis N, Hwang SR, Sei C, Byrne M, Yasothornsrikul S. Alpha1-antichymotrypsin-like proteins I and II purified from bovine adrenal medulla are enriched in chromaffin granules and inhibit the proenkephalin processing enzyme "prohormone thiol protease". J Neurochem. 1999 Jul; 73(1):59-69. PMID: 10386955.
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    104. Yasothornsrikul S, Aaron W, Toneff T, Hook V. Evidence for the proenkephalin processing enzyme prohormone thiol protease (PTP) as a multicatalytic cysteine protease complex: activation by glutathione localized to secretory vesicles. Biochemistry. 1999 Jun 08; 38(23):7421-30. PMID: 10360939.
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    105. Hook V, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J Biol Chem. 1999 Jan 29; 274(5):3165-72. PMID: 9915856.
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    106. Hwang SR, Steineckert B, Kohn A, Palkovits M, Hook V. Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver. J Biol Chem. 1999 Jan 15; 274(3):1821-7. PMID: 9880565.
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    107. Efthimiopoulos S, Floor E, Georgakopoulos A, Shioi J, Cui W, Yasothornsrikul S, Hook V, Wisniewski T, Buee L, Robakis NK. Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles. J Neurochem. 1998 Dec; 71(6):2365-72. PMID: 9832134.
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    108. Tezapsidis N, Li HC, Ripellino JA, Efthimiopoulos S, Vassilacopoulou D, Sambamurti K, Toneff T, Yasothornsrikul S, Hook V, Robakis NK. Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 1998 Feb 03; 37(5):1274-82. PMID: 9477953.
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    109. Yasothornsrikul S, Toneff T, Hwang SR, Hook V. Arginine and lysine aminopeptidase activities in chromaffin granules of bovine adrenal medulla: relevance to prohormone processing. J Neurochem. 1998 Jan; 70(1):153-63. PMID: 9422358.
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    110. Hwang SR, Palkovits M, Hook V. High level expression and characterization of recombinant human hippocampus phenol sulfotransferase: a novel phenol-sulfating form of phenol sulfotransferase. Protein Expr Purif. 1997 Oct; 11(1):125-34. PMID: 9325148.
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    111. Hook V, Moran K, Kannan R, Kohn A, Lively MO, Azaryan A, Schiller M, Miller K. High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing. Protein Expr Purif. 1997 Jun; 10(1):80-8. PMID: 9179294.
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    112. Hook V, Schiller MR, Nguyen C, Yasothornsrikul S. Production of radiolabeled neuropeptide precursors by in vitro transcription and translation. Pept Res. 1996 Jul-Aug; 9(4):183-7. PMID: 8914165.
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    113. Hook V, Schiller MR, Azaryan AV. The processing proteases prohormone thiol protease, PC1/3 and PC2, and 70-kDa aspartic proteinase show preferences among proenkephalin, proneuropeptide Y, and proopiomelanocortin substrates. Arch Biochem Biophys. 1996 Apr 01; 328(1):107-14. PMID: 8638918.
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    114. Hook V, Schiller MR, Azaryan AV, Tezapsidis N. Proenkephalin-processing enzymes in chromaffin granules: model for neuropeptide biosynthesis. Ann N Y Acad Sci. 1996 Mar 22; 780:121-33. PMID: 8602725.
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    115. Schiller MR, Kohn AB, Mende-Muelller LM, Miller K, Hook V. Expression of recombinant pro-neuropeptide Y, proopiomelanocortin, and proenkephalin: relative processing by 'prohormone thiol protease' (PTP). FEBS Lett. 1996 Mar 11; 382(1-2):6-10. PMID: 8612764.
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    116. Azaryan AV, Schiller MR, Hook V. Chromaffin granule aspartic proteinase processes recombinant proopiomelanocortin (POMC). Biochem Biophys Res Commun. 1995 Oct 24; 215(3):937-44. PMID: 7488064.
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    117. Azaryan AV, Schiller M, Mende-Mueller L, Hook V. Characteristics of the chromaffin granule aspartic proteinase involved in proenkephalin processing. J Neurochem. 1995 Oct; 65(4):1771-9. PMID: 7561875.
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    118. Hwang SR, Kohn AB, Hook V. Unique reactive site domains of neuroendocrine isoforms of alpha 1-antichymotrypsin from bovine adrenal medulla and pituitary revealed by molecular cloning. FEBS Lett. 1995 Jul 24; 368(3):471-6. PMID: 7635201.
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    119. Schiller MR, Mende-Mueller L, Moran K, Meng M, Miller KW, Hook V. "Prohormone thiol protease" (PTP) processing of recombinant proenkephalin. Biochemistry. 1995 Jun 27; 34(25):7988-95. PMID: 7794912.
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    120. Tezapsidis N, Noctor S, Kannan R, Krieger TJ, Mende-Mueller L, Hook V. Stimulation of "prohormone thiol protease" (PTP) and [Met]enkephalin by forskolin. Blockade of elevated [Met]enkephalin by a cysteine protease inhibitor of PTP. J Biol Chem. 1995 Jun 02; 270(22):13285-90. PMID: 7768928.
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    121. Vassilacopoulou D, Ripellino JA, Tezapsidis N, Hook V, Robakis NK. Full-length and truncated Alzheimer amyloid precursors in chromaffin granules: solubilization of membrane amyloid precursor is mediated by an enzymatic mechanism. J Neurochem. 1995 May; 64(5):2140-6. PMID: 7722498.
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    122. Azaryan AV, Krieger TJ, Hook V. Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granules. J Biol Chem. 1995 Apr 07; 270(14):8201-8. PMID: 7713926.
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    123. Hwang SR, Kohn AB, Hook V. Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus. Biochem Biophys Res Commun. 1995 Feb 15; 207(2):701-7. PMID: 7864863.
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    124. Hook V, Azaryan AV, Hwang SR, Tezapsidis N. Proteases and the emerging role of protease inhibitors in prohormone processing. FASEB J. 1994 Dec; 8(15):1269-78. PMID: 8001739.
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    125. Azaryan AV, Hook V. Distinct properties of prohormone thiol protease (PTP) compared to cathepsins B, L, and H: evidence for PTP as a novel cysteine protease. Arch Biochem Biophys. 1994 Oct; 314(1):171-7. PMID: 7944391.
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    126. Hwang SR, Kohn AB, Hook V. Molecular cloning reveals isoforms of bovine alpha 1-antichymotrypsin. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9579-83. PMID: 7937809; PMCID: PMC44856.
    127. Hwang SR, Hook V. Identification of carboxypeptidase H transcripts by antisense RNA. Brain Res Mol Brain Res. 1994 Aug; 25(1-2):135-9. PMID: 7984038.
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    128. Azaryan AV, Hook V. Unique cleavage specificity of 'prohormone thiol protease' related to proenkephalin processing. FEBS Lett. 1994 Mar 21; 341(2-3):197-202. PMID: 8137939.
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    129. Hook V, Purviance RT, Azaryan AV, Hubbard G, Krieger TJ. Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing. J Biol Chem. 1993 Sep 25; 268(27):20570-7. PMID: 8376411.
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    130. Krieger TJ, Mende-Mueller L, Hook V. Prohormone thiol protease and enkephalin precursor processing: cleavage at dibasic and monobasic sites. J Neurochem. 1992 Jul; 59(1):26-31. PMID: 1613503.
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    131. Azaryan AV, Hook V. Kex2-like proteolytic activity in adrenal medullary chromaffin granules. Biochem Biophys Res Commun. 1992 May 29; 185(1):398-403. PMID: 1599477.
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    132. Krieger TJ, Hook V. Purification and characterization of a cathepsin D protease from bovine chromaffin granules. Biochemistry. 1992 May 05; 31(17):4223-31. PMID: 1567870.
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    133. Toomim CS, Hook V. Thiol and aspartyl proteolytic activities in secretory vesicles of bovine pituitary. Biochem Biophys Res Commun. 1992 Mar 16; 183(2):449-55. PMID: 1550554.
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    134. Krieger TJ, Hook V. Purification and characterization of a novel thiol protease involved in processing the enkephalin precursor. J Biol Chem. 1991 May 05; 266(13):8376-83. PMID: 2022653.
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    135. Hook V, Affolter HU, Palkovits M. Carboxypeptidase H in the hypothalamo-neurohypophysial system: evidence for processing and activation of a prohormone-processing enzyme during axonal transport. J Neurosci. 1990 Oct; 10(10):3219-26. PMID: 1698942.
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    136. Hook V, Hegerle D, Affolter HU. Cleavage of recombinant enkephalin precursor by endoproteolytic activity in bovine chromaffin granules. Biochem Biophys Res Commun. 1990 Mar 16; 167(2):722-30. PMID: 2182020.
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    137. Hook V. Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme. Life Sci. 1990; 47(13):1135-9. PMID: 2122147.
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    138. Schwarzenbrunner U, Schmidle T, Obendorf D, Scherman D, Hook V, Fischer-Colbrie R, Winkler H. Sympathetic axons and nerve terminals: the protein composition of small and large dense-core and of a third type of vesicles. Neuroscience. 1990; 37(3):819-27. PMID: 2123305.
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    139. Hook V, Affolter HU. Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones. FEBS Lett. 1988 Oct 10; 238(2):338-42. PMID: 2458970.
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    140. Hook V. Regulation of carboxypeptidase H by inhibitory and stimulatory mechanisms during neuropeptide precursor processing. Cell Mol Neurobiol. 1988 Mar; 8(1):49-55. PMID: 3135937.
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    141. Chesselet MF, Hook V. Carboxypeptidase H-like immunoreactivity in the striatum of cats and monkeys. Regul Pept. 1988 Feb; 20(2):151-9. PMID: 2452460.
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    142. Hook V, LaGamma EF. Product inhibition of carboxypeptidase H. J Biol Chem. 1987 Sep 15; 262(26):12583-8. PMID: 2887569.
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    143. Hook V, Liston D. Distribution of enkephalin-containing peptides within bovine chromaffin granules. Neuropeptides. 1987 May-Jun; 9(4):263-7. PMID: 3302749.
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    144. Hook V. Differential distribution of carboxypeptidase-processing enzyme activity and immunoreactivity in membrane and soluble components of chromaffin granules. J Neurochem. 1985 Sep; 45(3):987-9. PMID: 3928813.
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    145. Hook V, Mezey E, Fricker LD, Pruss RM, Siegel RE, Brownstein MJ. Immunochemical characterization of carboxypeptidase B-like peptide-hormone-processing enzyme. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4745-9. PMID: 3927290; PMCID: PMC390981.
    146. Hook V, Eiden LE, Pruss RM. Selective regulation of carboxypeptidase peptide hormone-processing enzyme during enkephalin biosynthesis in cultured bovine adrenomedullary chromaffin cells. J Biol Chem. 1985 May 25; 260(10):5991-7. PMID: 4039723.
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    147. Hook V, Eiden LE. (Met)enkephalin and carboxypeptidase processing enzyme are co-released from chromaffin cells by cholinergic stimulation. Biochem Biophys Res Commun. 1985 Apr 30; 128(2):563-70. PMID: 3994713.
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    148. Hook V, Eiden LE. Two peptidases that convert 125I-Lys-Arg-(Met)enkephalin and 125I-(Met)enkephalin-Arg6, respectively, to 125I-(Met)enkephalin in bovine adrenal medullary chromaffin granules. FEBS Lett. 1984 Jul 09; 172(2):212-8. PMID: 6378657.
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    149. Hook V, Loh YP. Carboxypeptidase B-like converting enzyme activity in secretory granules of rat pituitary. Proc Natl Acad Sci U S A. 1984 May; 81(9):2776-80. PMID: 6326144; PMCID: PMC345153.
    150. Hook V. Carboxypeptidase B-like activity for the processing of enkephalin precursors in the membrane component of bovine adrenomedullary chromaffin granules. Neuropeptides. 1984 Mar; 4(2):117-26. PMID: 6546974.
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    151. Heisler S, Hook V, Axelrod J. Corticotropin releasing factor stimulation of protein carboxylmethylation in mouse pituitary tumor cells. Biochem Pharmacol. 1983 Apr 01; 32(7):1295-9. PMID: 6303356.
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    152. Reisine TD, Heisler S, Hook V, Axelrod J. Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release. J Neurosci. 1983 Apr; 3(4):725-32. PMID: 6300355.
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    153. Heisler S, Reisine TD, Hook V, Axelrod J. Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. Proc Natl Acad Sci U S A. 1982 Nov; 79(21):6502-6. PMID: 6128732; PMCID: PMC347155.
    154. Reisine T, Heisler S, Hook V, Axelrod J. Multireceptor-induced release of adrenocorticotropin from anterior pituitary tumor cells. Biochem Biophys Res Commun. 1982 Oct 15; 108(3):1251-7. PMID: 6295371.
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    155. Hook V, Heisler S, Sabol SL, Axelrod J. Corticotropin releasing factor stimulates adrenocorticotropin and beta-endorphin release from AtT-20 mouse pituitary tumor cells. Biochem Biophys Res Commun. 1982 Jun 30; 106(4):1364-71. PMID: 6288045.
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    156. Hook V, Eiden LE, Brownstein MJ. A carboxypeptidase processing enzyme for enkephalin precursors. Nature. 1982 Jan 28; 295(5847):341-2. PMID: 7057899.
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