Vivian Hook

Title(s)	Professor, School of Pharmacy and Pharmaceutical Science
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Biography

Education and Training

Ph.D.

University of California, San Francisco

Overview

Interests

Proteomics, Neurodegenerative Disease, Protein Biochemistry, Protease Inhibitors, Proteases, Peptide Neurotransmitters

Websites

Department of Pharmacology

Research

Research Activities and Funding

Development of molecular probe inhibitors of pathogenic, cytosolic cathespin B in traumatic brain injury and Alzheimers Disease neurodegeneration
NIH/NINDS R01NS109075Aug 1, 2019 - Jun 30, 2024
Role: Principal Investigator

Role of Human-Specific Cathepsin V Protease in the Production of Opioid and Related Peptide Neurotransmitters
NIH/NINDS R01NS094597Feb 15, 2019 - Jul 31, 2020
Role: Principal Investigator

Dynorphin Antisense Oligonucleotides for Alleviation of Chronic Pain without Addiction
NIH/NIDA R21DA044515Jun 1, 2018 - May 31, 2020
Role: Principal Investigator

Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
NIH R56AG057469Sep 15, 2017 - Aug 31, 2019
Role: Co-Principal Investigator

Aminopeptidases for Neurotoxic Pyroglutamate Beta-Amyloid of Alzheimers Disease
NIH/NIA R21AG042828Jul 1, 2013 - Apr 30, 2015
Role: Principal Investigator

Huntington's Disease Natural Product Drug Discovery
NIH R21AG038772Sep 1, 2011 - Aug 31, 2015
Role: Principal Investigator

Proteolytic Fragments of Mutant Huntingtin Protein in HD Brain Regions
NIH/NINDS R21NS063064Jun 1, 2010 - May 31, 2013
Role: Principal Investigator

POMC Processing and Beta-Endorphine-Related Opioid Peptides
NIH/NIMH R01MH077305May 15, 2006 - Apr 30, 2013
Role: Principal Investigator

Proteomics/Genomics of Opiate Analgesia and Addiction
NIH/NIDA R21DA015532Aug 1, 2003 - May 31, 2006
Role: Principal Investigator

Integrated DNA Sequencing System
NIH/NCRR S10RR016614Jul 15, 2002 - May 31, 2004
Role: Principal Investigator

Training in Neuroscience Related to Drug Abuse
NIH/NIDA T32DA007315Jul 1, 2000 - Jun 30, 2014
Role: Principal Investigator

Sympathetic Neuroeffector Junctions &Blood Pressure
NIH P01HL058120Jun 1, 1999 - May 31, 2012
Role: Co-Investigator

POMC PROCESSING &BETA-ENDORPHIN RELATED OPIOID PEPTIDE
NIH/NIDA R01DA008825Jun 1, 1996 - Oct 14, 2000
Role: Principal Investigator

OPIATE PRECURSOR PROCESSING
NIH/NIDA K02DA000228Apr 1, 1995 - Mar 31, 2000
Role: Principal Investigator

Serpin Protease Inhibitors &Opioid Neuropeptides
NIH/NINDS R01NS024553Apr 1, 1987 - Oct 14, 2000
Role: Principal Investigator

Biosynthesis of Enkephalin Opioid Peptides
NIH/NIDA R01DA004271Jan 1, 1987 - Oct 31, 2009
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.

View in: PubMed Mentions: 47 Fields:
Bio Biochemistry Bio Biophysics Mol Molecular Biology
Translation:Humans Animals Cells
Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. J Am Soc Mass Spectrom. 2018 05; 29(5):807-816. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. PMID: 29667161; PMCID: PMC5946320.

View in: PubMed Mentions: 24 Fields:
Che Chemistry Techniques
Translation:Humans Animals Cells
The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478; PMCID: PMC4902163.

View in: PubMed Mentions: 22 Fields:
Pha Pharmacology Tox Toxicology
Translation:Humans Animals Cells
Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. J Am Soc Mass Spectrom. 2015 Dec; 26(12):1970-80. Hook V, Bandeira N. PMID: 26483184; PMCID: PMC4749436.

View in: PubMed Mentions: 14 Fields:
Che Chemistry Techniques
Translation:Humans Cells
Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. PMID: 25358781; PMCID: PMC4223699.

View in: PubMed Mentions: 60 Fields:
Cel Cell Biology
Translation:Humans Cells
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochim Biophys Acta. 2012 Jan; 1824(1):89-104. Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. PMID: 21925292; PMCID: PMC3232284.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals Cells
Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. AAPS J. 2010 Dec; 12(4):635-45. Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. PMID: 20734175; PMCID: PMC2976990.

View in: PubMed Mentions: 15 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans Cells
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biol Chem. 2010 Aug; 391(8):861-72. Hook V, Hook G, Kindy M. PMID: 20536395; PMCID: PMC4309269.

View in: PubMed Mentions: 19 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein. Biochem Biophys Res Commun. 2009 Aug 21; 386(2):284-8. Hook VY, Kindy M, Reinheckel T, Peters C, Hook G. PMID: 19501042; PMCID: PMC2753505.

View in: PubMed Mentions: 44 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Animals
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 2009 Jun; 35(3):429-37. Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. PMID: 19343278; PMCID: PMC2731682.

View in: PubMed Mentions: 11 Fields:
End Endocrinology
Translation:Humans
Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biol Chem. 2008 Aug; 389(8):993-1006. Hook V, Schechter I, Demuth HU, Hook G. PMID: 18979625; PMCID: PMC2654319.

View in: PubMed Mentions: 25 Fields:
Bio Biochemistry
Translation:Humans Animals
Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells. Neuropeptides. 2008 Oct-Dec; 42(5-6):503-11. Hook V, Toneff T, Baylon S, Sei C. PMID: 18619673; PMCID: PMC2745396.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Neu Neurology
Translation:Animals Cells
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein. J Biol Chem. 2008 Mar 21; 283(12):7745-53. Hook VY, Kindy M, Hook G. PMID: 18184658.

View in: PubMed Mentions: 95 Fields:
Bio Biochemistry
Translation:Humans Animals
Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu Rev Pharmacol Toxicol. 2008; 48:393-423. Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. PMID: 18184105; PMCID: PMC2731677.

View in: PubMed Mentions: 112 Fields:
Pha Pharmacology Tox Toxicology
Translation:Humans Animals
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biol Chem. 2007 Feb; 388(2):247-52. Hook V, Kindy M, Hook G. PMID: 17261088.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
Translation:Animals Cells
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biol Chem. 2006 Oct-Nov; 387(10-11):1429-39. Hook VY. PMID: 17081116.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):449-69. Hook VY. PMID: 16724274.

View in: PubMed Mentions: 10 Fields:
Cel Cell Biology Mol Molecular Biology Neu Neurology
Translation:Humans Animals Cells
Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005 Sep; 386(9):931-40. Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. PMID: 16164418.

View in: PubMed Mentions: 69 Fields:
Bio Biochemistry
Translation:Animals Cells
Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun; 385(6):473-80. Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. PMID: 15255178.

View in: PubMed Mentions: 23 Fields:
Bio Biochemistry
Translation:Animals Cells
Evidence for functional localization of the proenkephalin-processing enzyme, prohormone thiol protease, to secretory vesicles of chromaffin cells. Endocrinology. 1999 Aug; 140(8):3744-54. Hook VY, Noctor S, Sei CA, Toneff T, Yasothornsrikul S, Kang YH. PMID: 10433235.

View in: PubMed Mentions: 4 Fields:
End Endocrinology
Translation:Animals Cells
The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. J Biol Chem. 1999 Jan 29; 274(5):3165-72. Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. PMID: 9915856.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Animals Cells
High-level expression of the prohormones proenkephalin, pro-neuropeptide Y, proopiomelanocortin, and beta-protachykinin for in vitro prohormone processing. Protein Expr Purif. 1997 Jun; 10(1):80-8. Hook VY, Moran K, Kannan R, Kohn A, Lively MO, Azaryan A, Schiller M, Miller K. PMID: 9179294.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology
Translation:Animals Cells