Hiutung Chu

Title(s)Assistant Professor, Pathology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0000-0001-7489-0446 Additional info
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    Collapse Biography 
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    UC BerkeleyBS
    UC DavisPhD

    Collapse Overview 
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    The Microbiome Mediates Protections from Colitis Through Pathways Linked to IBD
    NIH R00DK110534Apr 12, 2018 - Apr 11, 2021
    Role: Principal Investigator
    The Microbiome Mediates Protections from Colitis Through Pathways Linked to IBD
    NIH K99DK110534Sep 8, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Microbiome-induced autophagy as a novel therapy for inflammatory bowel disease
    NIH F32DK100109Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. Nat Microbiol. 2024 Feb; 9(2):336-345. Zuffa S, Schmid R, Bauermeister A, P Gomes PW, Caraballo-Rodriguez AM, El Abiead Y, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, Pessotti RC, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Silva Dos Santos M, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, Vera Ponce de León A, Pope PB, La Rosa SL, La Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC. PMID: 38316926; PMCID: PMC10847041.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    2. A bacterial sialidase mediates early-life colonization by a pioneering gut commensal. Cell Host Microbe. 2024 Feb 14; 32(2):181-190.e9. Buzun E, Hsu CY, Sejane K, Oles RE, Vasquez Ayala A, Loomis LR, Zhao J, Rossitto LA, McGrosso DM, Gonzalez DJ, Bode L, Chu H. PMID: 38228143; PMCID: PMC10922750.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Pangenome comparison of Bacteroides fragilis genomospecies unveil genetic diversity and ecological insights. bioRxiv. 2023 Dec 21. Oles RE, Terrazas MC, Loomis LR, Hsu CY, Tribelhorn C, Ferre PB, Ea A, Bryant M, Young J, Carrow HC, Sandborn WJ, Dulai P, Sivagnanam M, Pride D, Knight R, Chu H. PMID: 38187556; PMCID: PMC10769428.
      View in: PubMed   Mentions:
    4. Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice. J Exp Med. 2024 Jan 01; 221(1). Vasquez Ayala A, Hsu CY, Oles RE, Matsuo K, Loomis LR, Buzun E, Carrillo Terrazas M, Gerner RR, Lu HH, Kim S, Zhang Z, Park JH, Rivaud P, Thomson M, Lu LF, Min B, Chu H. PMID: 38085267; PMCID: PMC10716256.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Reverse metabolomics for the discovery of chemical structures from humans. Nature. 2024 Feb; 626(7998):419-426. Gentry EC, Collins SL, Panitchpakdi M, Belda-Ferre P, Stewart AK, Carrillo Terrazas M, Lu HH, Zuffa S, Yan T, Avila-Pacheco J, Plichta DR, Aron AT, Wang M, Jarmusch AK, Hao F, Syrkin-Nikolau M, Vlamakis H, Ananthakrishnan AN, Boland BS, Hemperly A, Vande Casteele N, Gonzalez FJ, Clish CB, Xavier RJ, Chu H, Baker ES, Patterson AD, Knight R, Siegel D, Dorrestein PC. PMID: 38052229; PMCID: PMC10849969.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity. Nat Immunol. 2023 Dec; 24(12):2108-2120. Lin CH, Wu CJ, Cho S, Patkar R, Huth WJ, Lin LL, Chen MC, Israelsson E, Betts J, Niedzielska M, Patel SA, Duong HG, Gerner RR, Hsu CY, Catley M, Maciewicz RA, Chu H, Raffatellu M, Chang JT, Lu LF. PMID: 37932457.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data. Res Sq. 2023 Aug 03. Zuffa S, Schmid R, Bauermeister A, Gomes PWP, Caraballo-Rodriguez AM, Abiead YE, Aron AT, Gentry EC, Zemlin J, Meehan MJ, Avalon NE, Cichewicz RH, Buzun E, Terrazas MC, Hsu CY, Oles R, Ayala AV, Zhao J, Chu H, Kuijpers MCM, Jackrel SL, Tugizimana F, Nephali LP, Dubery IA, Madala NE, Moreira EA, Costa-Lotufo LV, Lopes NP, Rezende-Teixeira P, Jimenez PC, Rimal B, Patterson AD, Traxler MF, de Cassia Pessotti R, Alvarado-Villalobos D, Tamayo-Castillo G, Chaverri P, Escudero-Leyva E, Quiros-Guerrero LM, Bory AJ, Joubert J, Rutz A, Wolfender JL, Allard PM, Sichert A, Pontrelli S, Pullman BS, Bandeira N, Gerwick WH, Gindro K, Massana-Codina J, Wagner BC, Forchhammer K, Petras D, Aiosa N, Garg N, Liebeke M, Bourceau P, Kang KB, Gadhavi H, de Carvalho LPS, Dos Santos MS, Pérez-Lorente AI, Molina-Santiago C, Romero D, Franke R, Brönstrup M, de León AVP, Pope PB, Rosa SL, Barbera G, Roager HM, Laursen MF, Hammerle F, Siewert B, Peintner U, Licona-Cassani C, Rodriguez-Orduña L, Rampler E, Hildebrand F, Koellensperger G, Schoeny H, Hohenwallner K, Panzenboeck L, Gregor R, O'Neill EC, Roxborough ET, Odoi J, Bale NJ, Ding S, Sinninghe Damsté JS, Guan XL, Cui JJ, Ju KS, Silva DB, Silva FMR, da Silva GF, Koolen HHF, Grundmann C, Clement JA, Mohimani H, Broders K, McPhail KL, Ober-Singleton SE, Rath CM, McDonald D, Knight R, Wang M, Dorrestein PC. PMID: 37577622; PMCID: PMC10418563.
      View in: PubMed   Mentions:
    8. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity. bioRxiv. 2023 Feb 21. Lin CH, Wu CJ, Cho S, Patkar R, Lin LL, Chen MC, Israelsson E, Betts J, Niedzielska M, Patel SA, Duong HG, Gerner RR, Hsu CY, Catley M, Maciewicz RA, Chu H, Raffatellu M, Chang JT, Lu LF. PMID: 36865314; PMCID: PMC9980002.
      View in: PubMed   Mentions:
    9. RNA binding protein DDX5 restricts RORγt+ Treg suppressor function to promote intestine inflammation. Sci Adv. 2023 02 03; 9(5):eadd6165. Ma S, Yang Q, Chen N, Zheng A, Abbasi N, Wang G, Patel PR, Cho BS, Yee BA, Zhang L, Chu H, Evans SM, Yeo GW, Zheng Y, Huang WJM. PMID: 36724232; PMCID: PMC9891705.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. Cell Mol Gastroenterol Hepatol. 2022; 14(1):35-53. Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. PMID: 35378331; PMCID: PMC9117812.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    11. Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity. Nat Microbiol. 2022 02; 7(2):262-276. Mills RH, Dulai PS, Vázquez-Baeza Y, Sauceda C, Daniel N, Gerner RR, Batachari LE, Malfavon M, Zhu Q, Weldon K, Humphrey G, Carrillo-Terrazas M, Goldasich LD, Bryant M, Raffatellu M, Quinn RA, Gewirtz AT, Chassaing B, Chu H, Sandborn WJ, Dorrestein PC, Knight R, Gonzalez DJ. PMID: 35087228; PMCID: PMC8852248.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    12. Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer. Front Cell Infect Microbiol. 2021; 11:752304. Campillo-Gimenez L, Rios-Covian D, Rivera-Nieves J, Kiyono H, Chu H, Ernst PB. PMID: 34869061; PMCID: PMC8633303.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). Finlay BB, Amato KR, Azad M, Blaser MJ, Bosch TCG, Chu H, Dominguez-Bello MG, Ehrlich SD, Elinav E, Geva-Zatorsky N, Gros P, Guillemin K, Keck F, Korem T, McFall-Ngai MJ, Melby MK, Nichter M, Pettersson S, Poinar H, Rees T, Tropini C, Zhao L, Giles-Vernick T. PMID: 33472859; PMCID: PMC8017729.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansPHPublic Health
    14. Strain diversity in the microbiome: Lessons from Bacteroides fragilis. PLoS Pathog. 2020 12; 16(12):e1009056. Carrow HC, Batachari LE, Chu H. PMID: 33301530; PMCID: PMC7728264.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    15. Microbial Metabolite Fortifies the Immune Firewall. Cell Host Microbe. 2020 11 11; 28(5):631-633. Chu H. PMID: 33181074.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice. Nat Microbiol. 2020 05; 5(5):746-756. Donaldson GP, Chou WC, Manson AL, Rogov P, Abeel T, Bochicchio J, Ciulla D, Melnikov A, Ernst PB, Chu H, Giannoukos G, Earl AM, Mazmanian SK. PMID: 32152589; PMCID: PMC7426998.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    17. Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis. Nat Commun. 2019 05 14; 10(1):2153. Ramakrishna C, Kujawski M, Chu H, Li L, Mazmanian SK, Cantin EM. PMID: 31089128; PMCID: PMC6517419.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    18. Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases. Gastroenterology. 2019 06; 156(8):2174-2189. Cohen LJ, Cho JH, Gevers D, Chu H. PMID: 30880022; PMCID: PMC6568267.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    19. Host gene-microbiome interactions: molecular mechanisms in inflammatory bowel disease. Genome Med. 2017 07 24; 9(1):69. Chu H. PMID: 28738853; PMCID: PMC5525272.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    20. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27; 352(6289):1116-20. Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. PMID: 27230380; PMCID: PMC4996125.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimalsCells
    21. Proteolysis Triggers Self-Assembly and Unmasks Innate Immune Function of a Human α-Defensin Peptide. Chem Sci. 2016 Mar 01; 7(3):1738-1752. Chairatana P, Chu H, Castillo PA, Shen B, Bevins CL, Nolan EM. PMID: 27076903; PMCID: PMC4827351.
      View in: PubMed   Mentions: 15  
    22. Winning the Microbial Battle, but Not the War. Cell. 2015 Oct 08; 163(2):271-2. Chu H, Mazmanian SK. PMID: 26451475.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires. Elife. 2015 Sep 30; 4:e09083. Yang Y, Wang C, Yang Q, Kantor AB, Chu H, Ghosn EE, Qin G, Mazmanian SK, Han J, Herzenberg LA. PMID: 26422511; PMCID: PMC4714975.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    24. Innate immune recognition of the microbiota promotes host-microbial symbiosis. Nat Immunol. 2013 Jul; 14(7):668-75. Chu H, Mazmanian SK. PMID: 23778794; PMCID: PMC4109969.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimals
    25. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Altern Med. 2012 Jun 29; 12:84. Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW. PMID: 22747752; PMCID: PMC3414771.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    26. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27; 337(6093):477-81. Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. PMID: 22722251; PMCID: PMC4332406.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    27. Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses. Pediatr Res. 2012 May; 71(5):546-51. Underwood MA, Kananurak A, Coursodon CF, Adkins-Reick CK, Chu H, Bennett SH, Wehkamp J, Castillo PA, Leonard BC, Tancredi DJ, Sherman MP, Dvorak B, Bevins CL. PMID: 22322385; PMCID: PMC3619207.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    28. Expression and activity of a novel cathelicidin from domestic cats. PLoS One. 2011 Apr 12; 6(4):e18756. Leonard BC, Chu H, Johns JL, Gallo RL, Moore PF, Marks SL, Bevins CL. PMID: 21533281; PMCID: PMC3075274.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    29. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol. 2010 Jan; 11(1):76-83. Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA. PMID: 19855381; PMCID: PMC2795796.
      View in: PubMed   Mentions: 553     Fields:    Translation:HumansAnimalsCells
    30. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009 May 08; 5(5):476-86. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ. PMID: 19454351; PMCID: PMC2768556.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansAnimalsCells
    31. Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. J Biol Chem. 2009 Feb 20; 284(8):4881-8. Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV. PMID: 19095652; PMCID: PMC2643518.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    32. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun. 2009 Jan; 77(1):387-98. Godinez I, Raffatellu M, Chu H, Paixão TA, Haneda T, Santos RL, Bevins CL, Tsolis RM, Bäumler AJ. PMID: 18955477; PMCID: PMC2612270.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    33. Regional variations in Paneth cell antimicrobial peptide expression along the mouse intestinal tract. BMC Immunol. 2008 Jul 17; 9:37. Karlsson J, Pütsep K, Chu H, Kays RJ, Bevins CL, Andersson M. PMID: 18637162; PMCID: PMC2488317.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    34. The capsule encoding the viaB locus reduces interleukin-17 expression and mucosal innate responses in the bovine intestinal mucosa during infection with Salmonella enterica serotype Typhi. Infect Immun. 2007 Sep; 75(9):4342-50. Raffatellu M, Santos RL, Chessa D, Wilson RP, Winter SE, Rossetti CA, Lawhon SD, Chu H, Lau T, Bevins CL, Adams LG, Bäumler AJ. PMID: 17591794; PMCID: PMC1951168.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    35. Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues. FEBS Lett. 2006 Oct 02; 580(22):5344-50. Wehkamp J, Chu H, Shen B, Feathers RW, Kays RJ, Lee SK, Bevins CL. PMID: 16989824.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    36. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18129-34. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. PMID: 16330776; PMCID: PMC1306791.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimalsCells
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