Sonia Podvin

Title(s)	Associate Project Scientist, School of Pharmacy and Pharmaceutical Science
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer's Disease Therapeutics. ACS Pharmacol Transl Sci. 2024 Oct 11; 7(10):2924-2935. Boyarko B, Podvin S, Greenberg B, Arnold S, Juanes AM, van der Kant R, Goldstein L, Momper JD, Bang A, Silverman J, Feldman HH, Hook V. PMID: 39421657; PMCID: PMC11480897.

View in: PubMed Mentions:
Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. Mol Psychiatry. 2024 May; 29(5):1440-1449. Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. PMID: 38302561; PMCID: PMC11189816.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology Psy Psychiatry
Translation:Humans Cells
Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracell Vesicles Circ Nucl Acids. 2023; 4(4):588-598. Hook V, Podvin S, Mosier C, Boyarko B, Seyffert L, Stringer H, Rissman RA. PMID: 38125374; PMCID: PMC10732590.

View in: PubMed Mentions: 2
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease. Front Pharmacol. 2023; 14:1190402. Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. PMID: 37601062; PMCID: PMC10436590.

View in: PubMed Mentions: 6
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range. Biochemistry. 2023 08 01; 62(15):2289-2300. Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V. PMID: 37459182; PMCID: PMC10399199.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Cells
Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems. J Huntingtons Dis. 2023; 12(4):315-333. Podvin S, Mosier C, Poon W, Wei E, Rossitto LA, Hook V. PMID: 38108356.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Humans
Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain. ACS Chem Neurosci. 2022 07 06; 13(13):1992-2005. Podvin S, Jiang Z, Boyarko B, Rossitto LA, O'Donoghue A, Rissman RA, Hook V. PMID: 35758417; PMCID: PMC9264367.

View in: PubMed Mentions: 12 Fields:
Neu Neurology
Translation:Humans Cells
Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases. ACS Chem Neurosci. 2022 01 19; 13(2):245-256. Yoon MC, Ames J, Mosier C, Jiang Z, Podvin S, O'Donoghue AJ, Hook V. PMID: 34986304; PMCID: PMC9070308.

View in: PubMed Mentions: 2 Fields:
Neu Neurology
Translation:Cells
Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. J Huntingtons Dis. 2022; 11(3):243-267. Podvin S, Rosenthal SB, Poon W, Wei E, Fisch KM, Hook V. PMID: 35871359; PMCID: PMC9484122.

View in: PubMed Mentions: 8 Fields:
Neu Neurology
Translation:Humans Animals
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions. ACS Chem Biol. 2021 09 17; 16(9):1628-1643. Yoon MC, Solania A, Jiang Z, Christy MP, Podvin S, Mosier C, Lietz CB, Ito G, Gerwick WH, Wolan DW, Hook G, O'Donoghue AJ, Hook V. PMID: 34416110; PMCID: PMC9104225.

View in: PubMed Mentions: 21 Fields:
Bio Biochemistry Bio Biology
Translation:Humans Cells
Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing. ACS Chem Neurosci. 2021 07 07; 12(13):2385-2398. Jiang Z, Lietz CB, Podvin S, Yoon MC, Toneff T, Hook V, O'Donoghue AJ. PMID: 34153188; PMCID: PMC8267839.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Cells
Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS Omega. 2021 May 25; 6(20):13033-13056. Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. PMID: 34056454; PMCID: PMC8158845.

View in: PubMed Mentions: 7
Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:434-450. Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. PMID: 33981778; PMCID: PMC8065227.

View in: PubMed Mentions: 7
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochim Biophys Acta Proteins Proteom. 2020 08; 1868(8):140428. Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. PMID: 32305689; PMCID: PMC7261628.

View in: PubMed Mentions: 57 Fields:
Bio Biochemistry Bio Biophysics Mol Molecular Biology
Translation:Humans Animals Cells
Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. PMID: 32295833; PMCID: PMC7261814.

View in: PubMed Mentions: 24 Fields:
Bio Biochemistry Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4. Cell Mol Life Sci. 2019 Dec; 76(24):5027-5039. Dang X, Coimbra R, Mao L, Podvin S, Li X, Yu H, Costantini TW, Zeng X, Larocca D, Eliceiri BP, Baird A. PMID: 31190084; PMCID: PMC11105628.

View in: PubMed Mentions: 5 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium. ACS Chem Neurosci. 2019 03 20; 10(3):1369-1379. Hook V, Kind T, Podvin S, Palazoglu M, Tran C, Toneff T, Samra S, Lietz C, Fiehn O. PMID: 30698015; PMCID: PMC7328367.

View in: PubMed Mentions: 4 Fields:
Neu Neurology
Translation:Animals Cells
Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development. J Mol Neurosci. 2018 Aug; 65(4):420-431. Hsu A, Podvin S, Hook V. PMID: 30008074; PMCID: PMC7185200.

View in: PubMed Mentions: 14 Fields:
Mol Molecular Biology Neu Neurology
Translation:Humans
Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon. 2018 Jul; 4(7):e00673. Podvin S, Wojnicz A, Hook V. PMID: 29998195; PMCID: PMC6037879.

View in: PubMed Mentions: 4
Multiple clinical features of Huntington's disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration. J Neurol. 2019 Mar; 266(3):551-564. Podvin S, Reardon HT, Yin K, Mosier C, Hook V. PMID: 29956026.

View in: PubMed Mentions: 22 Fields:
Neu Neurology
Translation:Humans Cells
Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. J Am Soc Mass Spectrom. 2018 05; 29(5):807-816. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. PMID: 29667161; PMCID: PMC5946320.

View in: PubMed Mentions: 26 Fields:
Che Chemistry Techniques
Translation:Humans Animals Cells
Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. J Am Soc Mass Spectrom. 2018 05; 29(5):935-947. Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. PMID: 29556927; PMCID: PMC5943185.

View in: PubMed Mentions: 11 Fields:
Che Chemistry Techniques
Translation:Animals Cells
Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats. Anal Chem. 2016 11 15; 88(22):10775-10784. Petras D, Nothias LF, Quinn RA, Alexandrov T, Bandeira N, Bouslimani A, Castro-Falcón G, Chen L, Dang T, Floros DJ, Hook V, Garg N, Hoffner N, Jiang Y, Kapono CA, Koester I, Knight R, Leber CA, Ling TJ, Luzzatto-Knaan T, McCall LI, McGrath AP, Meehan MJ, Merritt JK, Mills RH, Morton J, Podvin S, Protsyuk I, Purdy T, Satterfield K, Searles S, Shah S, Shires S, Steffen D, White M, Todoric J, Tuttle R, Wojnicz A, Sapp V, Vargas F, Yang J, Zhang C, Dorrestein PC. PMID: 27732780; PMCID: PMC6326777.

View in: PubMed Mentions: 21 Fields:
Che Chemistry Techniques
Translation:Humans
The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease. JSM Alzheimers Dis Relat Dement. 2016; 3(1). Podvin S, Miller MC, Rossi R, Chukwueke J, Donahue JE, Johanson CE, Baird A, Stopa EG. PMID: 27990492; PMCID: PMC5157699.

View in: PubMed Mentions: 6
The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2016; 56:511-33. Podvin S, Yaksh T, Hook V. PMID: 26738478; PMCID: PMC4902163.

View in: PubMed Mentions: 24 Fields:
Pha Pharmacology Tox Toxicology
Translation:Humans Animals Cells
Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Mol Cell Neurosci. 2015 Sep; 68:177-85. Podvin S, Bundey R, Toneff T, Ziegler M, Hook V. PMID: 26092702; PMCID: PMC4593749.

View in: PubMed Mentions: 15 Fields:
Cel Cell Biology Mol Molecular Biology Neu Neurology
Translation:Animals Cells
Esophageal cancer-related gene-4 (ECRG4) interactions with the innate immunity receptor complex. Inflamm Res. 2015 Feb; 64(2):107-18. Podvin S, Dang X, Meads M, Kurabi A, Costantini T, Eliceiri BP, Baird A, Coimbra R. PMID: 25511108; PMCID: PMC4301958.

View in: PubMed Mentions: 14 Fields:
All Allergy and Immunology Pat Pathology
Translation:Humans Cells
Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy. Gastrointest Cancer. 2014; 2014(4):131-142. Baird A, Lee J, Podvin S, Kurabi A, Dang X, Coimbra R, Costantini T, Bansal V, Eliceiri BP. PMID: 25580077; PMCID: PMC4287990.

View in: PubMed Mentions: 17
Cell-specific processing and release of the hormone-like precursor and candidate tumor suppressor gene product, Ecrg4. Cell Tissue Res. 2012 Jun; 348(3):505-14. Dang X, Podvin S, Coimbra R, Eliceiri B, Baird A. PMID: 22526622; PMCID: PMC3367106.

View in: PubMed Mentions: 28 Fields:
Cel Cell Biology His Histology
Translation:Humans Cells
Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury. PLoS One. 2011; 6(9):e24609. Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A. PMID: 21935431; PMCID: PMC3173480.

View in: PubMed Mentions: 33 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury. Fluids Barriers CNS. 2011 Jan 18; 8(1):6. Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP, Baird A. PMID: 21349154; PMCID: PMC3042980.

View in: PubMed Mentions: 42 Fields:
Bra Brain Neu Neurology
Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid. Brain Res. 2010 Nov 04; 1359:1-13. Gonzalez AM, Leadbeater W, Podvin S, Borboa A, Burg M, Sawada R, Rayner J, Sims K, Terasaki T, Johanson C, Stopa E, Eliceiri B, Baird A. PMID: 20732308; PMCID: PMC2955767.

View in: PubMed Mentions: 4 Fields:
Bra Brain
Translation:Animals Cells
Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 2008 Jan 01; 56(1):106-17. Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR. PMID: 17963266.

View in: PubMed Mentions: 71 Fields:
Neu Neurology
Translation:Animals
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19796-801. Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. PMID: 18056631; PMCID: PMC2148378.

View in: PubMed Mentions: 286 Fields:
Sci Science
Translation:Animals Cells