Teruaki Nakatsuji

Title(s)Associate Project Scientist, Dermatology
SchoolHealth Sciences
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Skin barrier function and the microbiome
    NIH/NIAID R01AI116576Jul 1, 2015 - Dec 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sawada Y, Tong Y, Barangi M, Hata T, Williams MR, Nakatsuji T, Gallo RL. Dilute bleach baths used for treatment of atopic dermatitis are not antimicrobial in vitro. J Allergy Clin Immunol. 2019 Jan 21. PMID: 30677478.
      View in: PubMed
    2. Nakatsuji T, Gallo RL. The role of the skin microbiome in atopic dermatitis. Ann Allergy Asthma Immunol. 2018 Dec 11. PMID: 30550810.
      View in: PubMed
    3. Dokoshi T, Zhang LJ, Nakatsuji T, Adase CA, Sanford JA, Paladini RD, Tanaka H, Fujiya M, Gallo RL. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018 Nov 02; 3(21). PMID: 30385720.
      View in: PubMed
    4. Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018 Feb; 4(2):eaao4502. PMID: 29507878.
      View in: PubMed
    5. Williams MR, Nakatsuji T, Gallo RL. Staphylococcus aureus: Master Manipulator of the Skin. Cell Host Microbe. 2017 11 08; 22(5):579-581. PMID: 29120738.
      View in: PubMed
    6. Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV, Latif H, Kim JN, Lockhart A, Artis K, David G, Taylor P, Streib J, Dorrestein PC, Grier A, Gill SR, Zengler K, Hata TR, Leung DY, Gallo RL. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017 02 22; 9(378). PMID: 28228596.
      View in: PubMed
    7. Williams MR, Nakatsuji T, Sanford JA, Vrbanac AF, Gallo RL. Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes. J Invest Dermatol. 2017 02; 137(2):377-384. PMID: 27765722.
      View in: PubMed
    8. Nakatsuji T, Chen TH, Two AM, Chun KA, Narala S, Geha RS, Hata TR, Gallo RL. Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol. 2016 11; 136(11):2192-2200. PMID: 27381887.
      View in: PubMed
    9. Two AM, Nakatsuji T, Kotol PF, Arvanitidou E, Du-Thumm L, Hata TR, Gallo RL. The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers. J Invest Dermatol. 2016 10; 136(10):1950-1954. PMID: 27377698.
      View in: PubMed
    10. Sato E, Muto J, Zhang LJ, Adase CA, Sanford JA, Takahashi T, Nakatsuji T, Usdin TB, Gallo RL. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016 07; 136(7):1449-1459. PMID: 27000502.
      View in: PubMed
    11. Bernard Q, Gallo RL, Jaulhac B, Nakatsuji T, Luft B, Yang X, Boulanger N. Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis. Exp Dermatol. 2016 Jan; 25(1):26-31. PMID: 26307945.
      View in: PubMed
    12. Bouslimani A, Porto C, Rath CM, Wang M, Guo Y, Gonzalez A, Berg-Lyon D, Ackermann G, Moeller Christensen GJ, Nakatsuji T, Zhang L, Borkowski AW, Meehan MJ, Dorrestein K, Gallo RL, Bandeira N, Knight R, Alexandrov T, Dorrestein PC. Molecular cartography of the human skin surface in 3D. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2120-9. PMID: 25825778; PMCID: PMC4418856.
    13. Murakami M, Kaneko T, Nakatsuji T, Kameda K, Okazaki H, Dai X, Hanakawa Y, Tohyama M, Ishida-Yamamoto A, Sayama K. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS One. 2014; 9(10):e110677. PMID: 25330301; PMCID: PMC4199729.
    14. MacLeod DT, Nakatsuji T, Wang Z, di Nardo A, Gallo RL. Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes. J Invest Dermatol. 2015 Jan; 135(1):142-150. PMID: 25089661; PMCID: PMC4268046.
    15. Nakatsuji T, Gallo RL. Dermatological therapy by topical application of non-pathogenic bacteria. J Invest Dermatol. 2014 Jan; 134(1):11-14. PMID: 24352078.
      View in: PubMed
    16. Two AM, Hata TR, Nakatsuji T, Coda AB, Kotol PF, Wu W, Shafiq F, Huang EY, Gallo RL. Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor. J Invest Dermatol. 2014 Apr; 134(4):1143-1145. PMID: 24213369; PMCID: PMC3970953.
    17. Nakatsuji T, Chiang HI, Jiang SB, Nagarajan H, Zengler K, Gallo RL. The microbiome extends to subepidermal compartments of normal skin. Nat Commun. 2013; 4:1431. PMID: 23385576; PMCID: PMC3655727.
    18. MacLeod DT, Nakatsuji T, Yamasaki K, Kobzik L, Gallo RL. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun. 2013; 4:1963. PMID: 23739639; PMCID: PMC3681428.
    19. Bernard JJ, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski AW, Martinez L, Greidinger EL, Yu BD, Gallo RL. Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat Med. 2012 Aug; 18(8):1286-90. PMID: 22772463; PMCID: PMC3812946.
    20. Kanada KN, Nakatsuji T, Gallo RL. Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin. J Invest Dermatol. 2012 May; 132(5):1435-42. PMID: 22336948; PMCID: PMC4169281.
    21. Nakatsuji T, Gallo RL. Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):887-95. PMID: 22158560; PMCID: PMC3279605.
    22. Gallo RL, Nakatsuji T. Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol. 2011 Oct; 131(10):1974-80. PMID: 21697881; PMCID: PMC3174284.
    23. Nakatsuji T, Tang DC, Zhang L, Gallo RL, Huang CM. Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment. PLoS One. 2011 Apr 12; 6(4):e14797. PMID: 21533261; PMCID: PMC3075254.
    24. Chen CH, Wang Y, Nakatsuji T, Liu YT, Zouboulis C, Gallo R, Zhang L, Hsieh MF, Huang CM. An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine. J Microbiol Biotechnol. 2011 Apr; 21(4):391-9. PMID: 21532323.
      View in: PubMed
    25. Liu PF, Nakatsuji T, Zhu W, Gallo RL, Huang CM. Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine. 2011 Apr 12; 29(17):3230-8. PMID: 21354482; PMCID: PMC3388602.
    26. Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol. 2011 Mar; 131(3):688-97. PMID: 21107351; PMCID: PMC3085277.
    27. Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang CM. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol. 2010 Apr; 130(4):985-94. PMID: 20032992; PMCID: PMC3057125.
    28. Panicker G, Mojib N, Nakatsuji T, Aislabie J, Bej AK. Occurrence and distribution of capB in Antarctic microorganisms and study of its structure and regulation in the Antarctic biodegradative Pseudomonas sp. 30/3. Extremophiles. 2010 Mar; 14(2):171-83. PMID: 20091073.
      View in: PubMed
    29. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009 Dec; 15(12):1377-82. PMID: 19966777; PMCID: PMC2880863.
    30. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009 Oct; 30(30):6035-40. PMID: 19665786; PMCID: PMC2735618.
    31. Lee DY, Huang CM, Nakatsuji T, Thiboutot D, Kang SA, Monestier M, Gallo RL. Histone H4 is a major component of the antimicrobial action of human sebocytes. J Invest Dermatol. 2009 Oct; 129(10):2489-96. PMID: 19536143; PMCID: PMC2765036.
    32. Nakatsuji T, Kao MC, Fang JY, Zouboulis CC, Zhang L, Gallo RL, Huang CM. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct; 129(10):2480-8. PMID: 19387482; PMCID: PMC2772209.
    33. Nakatsuji T, Lee CY, Watson RD. Crustacean molt-inhibiting hormone: structure, function, and cellular mode of action. Comp Biochem Physiol A Mol Integr Physiol. 2009 Feb; 152(2):139-48. PMID: 19000932.
      View in: PubMed
    34. Nakatsuji T, Rasochova L, Huang CM. Vaccine therapy for P. acnes-associated diseases. Infect Disord Drug Targets. 2008 Sep; 8(3):160-5. PMID: 18782033.
      View in: PubMed
    35. Nakatsuji T, Shi Y, Zhu W, Huang CP, Chen YR, Lee DY, Smith JW, Zouboulis CC, Gallo RL, Huang CM. Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo. Proteomics. 2008 Aug; 8(16):3406-15. PMID: 18651708; PMCID: PMC2699546.
    36. Huang CP, Liu YT, Nakatsuji T, Shi Y, Gallo RR, Lin SB, Huang CM. Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes. Proteomics Clin Appl. 2008 Sep; 2(9):1234-45. PMID: 21136919; PMCID: PMC3070417.
    37. Nakatsuji T, Liu YT, Huang CP, Zoubouis CC, Gallo RL, Huang CM. Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris. J Invest Dermatol. 2008 Oct; 128(10):2451-7. PMID: 18463682; PMCID: PMC3070419.
    38. Nakatsuji T, Liu YT, Huang CP, Zouboulis CC, Gallo RL, Huang CM. Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. PLoS One. 2008 Feb 06; 3(2):e1551. PMID: 18253498; PMCID: PMC2212713.
    39. Huang CM, Nakatsuji T, Liu YT, Shi Y. In vivo tumor secretion probing via ultrafiltration and tissue chamber: implication for anti-cancer drugs targeting secretome. Recent Pat Anticancer Drug Discov. 2008 Jan; 3(1):48-54. PMID: 18289123; PMCID: PMC2772193.
    40. Zheng J, Nakatsuji T, Roer RD, Watson RD. Studies of a receptor guanylyl cyclase cloned from Y-organs of the blue crab (Callinectes sapidus), and its possible functional link to ecdysteroidogenesis. Gen Comp Endocrinol. 2008 Feb 01; 155(3):780-8. PMID: 18093588.
      View in: PubMed
    41. Nakatsuji T, Han DW, Jablonsky MJ, Harville SR, Muccio DD, Watson RD. Expression of crustacean (Callinectes sapidus) molt-inhibiting hormone in Escherichia coli: characterization of the recombinant peptide and assessment of its effects on cellular signaling pathways in Y-organs. Mol Cell Endocrinol. 2006 Jul 11; 253(1-2):96-104. PMID: 16790313.
      View in: PubMed
    42. Nakatsuji T, Sonobe H, Watson RD. Molt-inhibiting hormone-mediated regulation of ecdysteroid synthesis in Y-organs of the crayfish (Procambarus clarkii): involvement of cyclic GMP and cyclic nucleotide phosphodiesterase. Mol Cell Endocrinol. 2006 Jul 11; 253(1-2):76-82. PMID: 16765511.
      View in: PubMed
    43. Ohira T, Katayama H, Tominaga S, Takasuka T, Nakatsuji T, Sonobe H, Aida K, Nagasawa H. Cloning and characterization of a molt-inhibiting hormone-like peptide from the prawn Marsupenaeus japonicus. Peptides. 2005 Feb; 26(2):259-68. PMID: 15629537.
      View in: PubMed
    44. Nakatsuji T, Sonobe H. Regulation of ecdysteroid secretion from the Y-organ by molt-inhibiting hormone in the American crayfish, Procambarus clarkii. Gen Comp Endocrinol. 2004 Feb; 135(3):358-64. PMID: 14723887.
      View in: PubMed
    45. Nakatsuji T, Sonobe H. Measurement of molt-inhibiting hormone titer in hemolymph of the American crayfish, Procambarus clarkii, by time-resolved fluoroimmunoassay. Zoolog Sci. 2003 Aug; 20(8):999-1001. PMID: 12951406.
      View in: PubMed
    46. Sonobe H, Nishimura T, Sonobe M, Nakatsuji T, Yanagihara R, Kawakami T, Aimoto S. The molt-inhibiting hormone in the American crayfish Procambarus clarkii: its chemical synthesis and biological activity. Gen Comp Endocrinol. 2001 Feb; 121(2):196-204. PMID: 11178885.
      View in: PubMed
    47. Nakatsuji T, Keino H, Tamura K, Yoshimura S, Kawakami T, Aimoto S, Sonobe H. Changes in the Amounts of the Molt-Inhibiting Hormone in Sinus Glands during the Molt Cycle of the American Crayfish, Procambarus clarkii. Zoolog Sci. 2000 Nov 01; 17(8):1129-36. PMID: 18522469.
      View in: PubMed
    48. Kawakami T, Toda C, Akaji K, Nishimura T, Nakatsuji T, Ueno K, Sonobe M, Sonobe H, Aimoto S. Synthesis of a molt-inhibiting hormone of the American crayfish, Procambarus clarkii, and determination of the location of its disulfide linkages. J Biochem. 2000 Sep; 128(3):455-61. PMID: 10965045.
      View in: PubMed