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Teruaki Nakatsuji

Title(s)Associate Project Scientist, Dermatology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Conflict and Cooperation between AMP Species on the skin
    NIH R01AR076082Jul 1, 2019 - Apr 30, 2024
    Role: Co-Principal Investigator
    Skin barrier function and the microbiome
    NIH R01AI116576Jul 1, 2015 - Dec 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial. Nat Med. 2021 Feb 22. Nakatsuji T, Hata TR, Tong Y, Cheng JY, Shafiq F, Butcher AM, Salem SS, Brinton SL, Rudman Spergel AK, Johnson K, Jepson B, Calatroni A, David G, Ramirez-Gama M, Taylor P, Leung DYM, Gallo RL. PMID: 33619370.
      View in: PubMed   Mentions:    Fields:    
    2. Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis. Sci Rep. 2020 Dec 04; 10(1):21237. Nakamura K, O'Neill AM, Williams MR, Cau L, Nakatsuji T, Horswill AR, Gallo RL. PMID: 33277548.
      View in: PubMed   Mentions:    Fields:    
    3. Sphingosine 1-Phosphate Receptor 2 Is Central to Maintaining Epidermal Barrier Homeostasis. J Invest Dermatol. 2020 Nov 14. PMID: 33197483.
      View in: PubMed   Mentions:    Fields:    
    4. Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis. J Allergy Clin Immunol. 2020 Jul 04. Cau L, Williams MR, Butcher AM, Nakatsuji T, Kavanaugh JS, Cheng JY, Shafiq F, Higbee K, Hata TR, Horswill AR, Gallo RL. PMID: 32634452.
      View in: PubMed   Mentions: 1     Fields:    
    5. A Nitric Oxide-Releasing Topical Medication as a Potential Treatment Option for Atopic Dermatitis through Antimicrobial and Anti-Inflammatory Activity. J Invest Dermatol. 2020 Dec; 140(12):2531-2535.e2. Guttman-Yassky E, Gallo RL, Pavel AB, Nakatsuji T, Li R, Zhang N, Messersmith E, Maeda-Chubachi T. PMID: 32428543.
      View in: PubMed   Mentions:    Fields:    
    6. Identification of a Human Skin Commensal Bacterium that Selectively Kills Cutibacterium acnes. J Invest Dermatol. 2020 Aug; 140(8):1619-1628.e2. O'Neill AM, Nakatsuji T, Hayachi A, Williams MR, Mills RH, Gonzalez DJ, Gallo RL. PMID: 31981578.
      View in: PubMed   Mentions: 3     Fields:    
    7. Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection. Cell Rep. 2020 01 07; 30(1):61-68.e4. Dokoshi T, Zhang LJ, Li F, Nakatsuji T, Butcher A, Yoshida H, Shimoda M, Okada Y, Gallo RL. PMID: 31914398.
      View in: PubMed   Mentions:    Fields:    
    8. Response to Comment on "A commensal strain of Staphylococcus epidermidis protects against skin neoplasia" by Nakatsuji et al. Sci Adv. 2019 09; 5(9):eaay5611. Nakatsuji T, Fenical W, Gallo RL. PMID: 31535030.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. IL-4Ra Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. J Invest Dermatol. 2020 01; 140(1):191-202.e7. Callewaert C, Nakatsuji T, Knight R, Kosciolek T, Vrbanac A, Kotol P, Ardeleanu M, Hultsch T, Guttman-Yassky E, Bissonnette R, Silverberg JI, Krueger J, Menter A, Graham NMH, Pirozzi G, Hamilton JD, Gallo RL. PMID: 31252032.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    10. Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis. Sci Transl Med. 2019 05 01; 11(490). Williams MR, Costa SK, Zaramela LS, Khalil S, Todd DA, Winter HL, Sanford JA, O'Neill AM, Liggins MC, Nakatsuji T, Cech NB, Cheung AL, Zengler K, Horswill AR, Gallo RL. PMID: 31043573.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Dilute bleach baths used for treatment of atopic dermatitis are not antimicrobial in vitro. J Allergy Clin Immunol. 2019 05; 143(5):1946-1948. Sawada Y, Tong Y, Barangi M, Hata T, Williams MR, Nakatsuji T, Gallo RL. PMID: 30677478.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. The role of the skin microbiome in atopic dermatitis. Ann Allergy Asthma Immunol. 2019 03; 122(3):263-269. Nakatsuji T, Gallo RL. PMID: 30550810.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    13. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018 11 02; 3(21). Dokoshi T, Zhang LJ, Nakatsuji T, Adase CA, Sanford JA, Paladini RD, Tanaka H, Fujiya M, Gallo RL. PMID: 30385720.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018 02; 4(2):eaao4502. Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. PMID: 29507878.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    15. Staphylococcus aureus: Master Manipulator of the Skin. . 2017 11 08; 22(5):579-581. Williams MR, Nakatsuji T, Gallo RL. PMID: 29120738.
      View in: PubMed   Mentions:
    16. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017 02 22; 9(378). PMID: 28228596.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes. J Invest Dermatol. 2017 02; 137(2):377-384. PMID: 27765722.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol. 2016 11; 136(11):2192-2200. PMID: 27381887.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    19. The Cutaneous Microbiome and Aspects of Skin Antimicrobial Defense System Resist Acute Treatment with Topical Skin Cleansers. J Invest Dermatol. 2016 10; 136(10):1950-1954. PMID: 27377698.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    20. The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol. 2016 07; 136(7):1449-1459. PMID: 27000502.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Ixodes tick saliva suppresses the keratinocyte cytokine response to TLR2/TLR3 ligands during early exposure to Lyme borreliosis. Exp Dermatol. 2016 Jan; 25(1):26-31. PMID: 26307945.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Molecular cartography of the human skin surface in 3D. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2120-9. PMID: 25825778.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    23. Vesicular LL-37 contributes to inflammation of the lesional skin of palmoplantar pustulosis. PLoS One. 2014; 9(10):e110677. PMID: 25330301.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes. J Invest Dermatol. 2015 Jan; 135(1):142-150. PMID: 25089661.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    25. Dermatological therapy by topical application of non-pathogenic bacteria. J Invest Dermatol. 2014 Jan; 134(1):11-14. PMID: 24352078.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor. J Invest Dermatol. 2014 Apr; 134(4):1143-1145. PMID: 24213369.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. The microbiome extends to subepidermal compartments of normal skin. Nat Commun. 2013; 4:1431. PMID: 23385576.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    28. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun. 2013; 4:1963. PMID: 23739639.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat Med. 2012 Aug; 18(8):1286-90. PMID: 22772463.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    30. Doxycycline indirectly inhibits proteolytic activation of tryptic kallikrein-related peptidases and activation of cathelicidin. J Invest Dermatol. 2012 May; 132(5):1435-42. PMID: 22336948.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    31. Antimicrobial peptides: old molecules with new ideas. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):887-95. PMID: 22158560.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    32. Microbial symbiosis with the innate immune defense system of the skin. J Invest Dermatol. 2011 Oct; 131(10):1974-80. Gallo RL, Nakatsuji T. PMID: 21697881.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    33. Propionibacterium acnes CAMP factor and host acid sphingomyelinase contribute to bacterial virulence: potential targets for inflammatory acne treatment. PLoS One. 2011 Apr 12; 6(4):e14797. PMID: 21533261.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    34. An innate bactericidal oleic acid effective against skin infection of methicillin-resistant Staphylococcus aureus: a therapy concordant with evolutionary medicine. J Microbiol Biotechnol. 2011 Apr; 21(4):391-9. PMID: 21532323.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    35. Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. Vaccine. 2011 Apr 12; 29(17):3230-8. Liu PF, Nakatsuji T, Zhu W, Gallo RL, Huang CM. PMID: 21354482.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol. 2011 Mar; 131(3):688-97. Yamasaki K, Kanada K, Macleod DT, Borkowski AW, Morizane S, Nakatsuji T, Cogen AL, Gallo RL. PMID: 21107351.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    37. Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression. J Invest Dermatol. 2010 Apr; 130(4):985-94. Nakatsuji T, Kao MC, Zhang L, Zouboulis CC, Gallo RL, Huang CM. PMID: 20032992.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    38. Occurrence and distribution of capB in Antarctic microorganisms and study of its structure and regulation in the Antarctic biodegradative Pseudomonas sp. 30/3. Extremophiles. 2010 Mar; 14(2):171-83. Panicker G, Mojib N, Nakatsuji T, Aislabie J, Bej AK. PMID: 20091073.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    39. Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med. 2009 Dec; 15(12):1377-82. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu ZR, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang CM, Ryan AF, Gallo RL. PMID: 19966777.
      View in: PubMed   Mentions: 205     Fields:    Translation:Humans
    40. The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes. Biomaterials. 2009 Oct; 30(30):6035-40. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L. PMID: 19665786.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    41. Histone H4 is a major component of the antimicrobial action of human sebocytes. J Invest Dermatol. 2009 Oct; 129(10):2489-96. Lee DY, Huang CM, Nakatsuji T, Thiboutot D, Kang SA, Monestier M, Gallo RL. PMID: 19536143.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    42. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct; 129(10):2480-8. Nakatsuji T, Kao MC, Fang JY, Zouboulis CC, Zhang L, Gallo RL, Huang CM. PMID: 19387482.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    43. Crustacean molt-inhibiting hormone: structure, function, and cellular mode of action. Comp Biochem Physiol A Mol Integr Physiol. 2009 Feb; 152(2):139-48. Nakatsuji T, Lee CY, Watson RD. PMID: 19000932.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Vaccine therapy for P. acnes-associated diseases. Infect Disord Drug Targets. 2008 Sep; 8(3):160-5. Nakatsuji T, Rasochova L, Huang CM. PMID: 18782033.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    45. Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to Propionibacterium acnes infection in vivo. Proteomics. 2008 Aug; 8(16):3406-15. Nakatsuji T, Shi Y, Zhu W, Huang CP, Chen YR, Lee DY, Smith JW, Zouboulis CC, Gallo RL, Huang CM. PMID: 18651708.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    46. Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes. Proteomics Clin Appl. 2008 Sep; 2(9):1234-45. Huang CP, Liu YT, Nakatsuji T, Shi Y, Gallo RR, Lin SB, Huang CM. PMID: 21136919.
      View in: PubMed   Mentions: 2     Fields:    
    47. Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris. J Invest Dermatol. 2008 Oct; 128(10):2451-7. Nakatsuji T, Liu YT, Huang CP, Zoubouis CC, Gallo RL, Huang CM. PMID: 18463682.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. PLoS One. 2008 Feb 06; 3(2):e1551. Nakatsuji T, Liu YT, Huang CP, Zouboulis CC, Gallo RL, Huang CM. PMID: 18253498.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCellsPHPublic Health
    49. In vivo tumor secretion probing via ultrafiltration and tissue chamber: implication for anti-cancer drugs targeting secretome. Recent Pat Anticancer Drug Discov. 2008 Jan; 3(1):48-54. Huang CM, Nakatsuji T, Liu YT, Shi Y. PMID: 18289123.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    50. Studies of a receptor guanylyl cyclase cloned from Y-organs of the blue crab (Callinectes sapidus), and its possible functional link to ecdysteroidogenesis. Gen Comp Endocrinol. 2008 Feb 01; 155(3):780-8. Zheng J, Nakatsuji T, Roer RD, Watson RD. PMID: 18093588.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    51. Expression of crustacean (Callinectes sapidus) molt-inhibiting hormone in Escherichia coli: characterization of the recombinant peptide and assessment of its effects on cellular signaling pathways in Y-organs. Mol Cell Endocrinol. 2006 Jul 11; 253(1-2):96-104. Nakatsuji T, Han DW, Jablonsky MJ, Harville SR, Muccio DD, Watson RD. PMID: 16790313.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. Molt-inhibiting hormone-mediated regulation of ecdysteroid synthesis in Y-organs of the crayfish (Procambarus clarkii): involvement of cyclic GMP and cyclic nucleotide phosphodiesterase. Mol Cell Endocrinol. 2006 Jul 11; 253(1-2):76-82. Nakatsuji T, Sonobe H, Watson RD. PMID: 16765511.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    53. Cloning and characterization of a molt-inhibiting hormone-like peptide from the prawn Marsupenaeus japonicus. Peptides. 2005 Feb; 26(2):259-68. Ohira T, Katayama H, Tominaga S, Takasuka T, Nakatsuji T, Sonobe H, Aida K, Nagasawa H. PMID: 15629537.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. Regulation of ecdysteroid secretion from the Y-organ by molt-inhibiting hormone in the American crayfish, Procambarus clarkii. Gen Comp Endocrinol. 2004 Feb; 135(3):358-64. Nakatsuji T, Sonobe H. PMID: 14723887.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    55. Measurement of molt-inhibiting hormone titer in hemolymph of the American crayfish, Procambarus clarkii, by time-resolved fluoroimmunoassay. Zoolog Sci. 2003 Aug; 20(8):999-1001. Nakatsuji T, Sonobe H. PMID: 12951406.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    56. The molt-inhibiting hormone in the American crayfish Procambarus clarkii: its chemical synthesis and biological activity. Gen Comp Endocrinol. 2001 Feb; 121(2):196-204. Sonobe H, Nishimura T, Sonobe M, Nakatsuji T, Yanagihara R, Kawakami T, Aimoto S. PMID: 11178885.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    57. Changes in the Amounts of the Molt-Inhibiting Hormone in Sinus Glands during the Molt Cycle of the American Crayfish, Procambarus clarkii. Zoolog Sci. 2000 Nov 01; 17(8):1129-36. Nakatsuji T, Keino H, Tamura K, Yoshimura S, Kawakami T, Aimoto S, Sonobe H. PMID: 18522469.
      View in: PubMed   Mentions: 2     Fields:    
    58. Synthesis of a molt-inhibiting hormone of the American crayfish, Procambarus clarkii, and determination of the location of its disulfide linkages. J Biochem. 2000 Sep; 128(3):455-61. Kawakami T, Toda C, Akaji K, Nishimura T, Nakatsuji T, Ueno K, Sonobe M, Sonobe H, Aimoto S. PMID: 10965045.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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