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Jeff Hasty

Title(s)Professor, Molecular Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #0349
La Jolla CA 92093
Phone8/8-22--3442
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    Collapse Research 
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    A microbiome-informed platform for the development and testing of bacterial therapies for colorectal cancer
    NIH/NCI R01CA241728May 18, 2020 - Apr 30, 2024
    Role: Principal Investigator
    Network-Driven Dynamics of Replicative Aging
    NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    The q-bio Summer School
    NIH/NIGMS R25GM105608Apr 1, 2013 - Jan 31, 2017
    Role: Principal Investigator
    Delays and variability in single-cell NFkB signaling
    NIH/NIGMS R01GM089976May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
    Role: Principal Investigator
    Metabolic Control in a Dynamic Environment
    NIH/NIGMS R01GM079333Apr 1, 2007 - Mar 31, 2011
    Role: Principal Investigator
    Engineered Gene Circuits for Basic Science and Biotechnology
    NIH/NIGMS R01GM069811Aug 1, 2004 - Jul 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A programmable fate decision landscape underlies single-cell aging in yeast. Science. 2020 Jul 17; 369(6501):325-329. Li Y, Jiang Y, Paxman J, O'Laughlin R, Klepin S, Zhu Y, Pillus L, Tsimring LS, Hasty J, Hao N. PMID: 32675375.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Interfacing gene circuits with microelectronics through engineered population dynamics. Sci Adv. 2020 May; 6(21):eaaz8344. Din MO, Martin A, Razinkov I, Csicsery N, Hasty J. PMID: 32494744.
      View in: PubMed   Mentions:    Fields:    
    3. One-Day Construction of Multiplex Arrays to Harness Natural CRISPR-Cas Systems. ACS Synth Biol. 2020 05 15; 9(5):1129-1137. Cooper RM, Hasty J. PMID: 32271547.
      View in: PubMed   Mentions:    Fields:    
    4. Genetically engineered control of phenotypic structure in microbial colonies. Nat Microbiol. 2020 05; 5(5):697-705. Bittihn P, Didovyk A, Tsimring LS, Hasty J. PMID: 32284568.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Inducible cell-to-cell signaling for tunable dynamics in microbial communities. Nat Commun. 2020 03 04; 11(1):1193. Miano A, Liao MJ, Hasty J. PMID: 32132536.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Genome-scale transcriptional dynamics and environmental biosensing. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3301-3306. Graham G, Csicsery N, Stasiowski E, Thouvenin G, Mather WH, Ferry M, Cookson S, Hasty J. PMID: 31974311.
      View in: PubMed   Mentions: 1     Fields:    Translation:CellsPHPublic Health
    7. Flower-like patterns in multi-species bacterial colonies. Elife. 2020 Jan 14; 9. Xiong L, Cao Y, Cooper R, Rappel WJ, Hasty J, Tsimring L. PMID: 31933477.
      View in: PubMed   Mentions: 2     Fields:    
    8. Rock-paper-scissors: Engineered population dynamics increase genetic stability. Science. 2019 09 06; 365(6457):1045-1049. Liao MJ, Din MO, Tsimring L, Hasty J. PMID: 31488693.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    9. Divergent Aging of Isogenic Yeast Cells Revealed through Single-Cell Phenotypic Dynamics. Cell Syst. 2019 03 27; 8(3):242-253.e3. Jin M, Li Y, O'Laughlin R, Bittihn P, Pillus L, Tsimring LS, Hasty J, Hao N. PMID: 30852250.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Microfluidics-Based Analysis of Contact-dependent Bacterial Interactions. Bio Protoc. 2018 Aug 20; 8(16). Cooper R, Tsimring L, Hasty J. PMID: 30370317.
      View in: PubMed   Mentions:
    11. Rational engineering of synthetic microbial systems: from single cells to consortia. Curr Opin Microbiol. 2018 10; 45:92-99. Bittihn P, Din MO, Tsimring LS, Hasty J. PMID: 29574330.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    12. Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance. Elife. 2017 11 01; 6. Cooper RM, Tsimring L, Hasty J. PMID: 29091031.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    13. Multigenerational silencing dynamics control cell aging. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):11253-11258. Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. PMID: 29073021.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression. ACS Synth Biol. 2017 12 15; 6(12):2198-2208. Didovyk A, Tonooka T, Tsimring L, Hasty J. PMID: 28795570.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. Synchronized DNA cycling across a bacterial population. Nat Genet. 2017 Aug; 49(8):1282-1285. Baumgart L, Mather W, Hasty J. PMID: 28692067.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    16. A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis. Nat Microbiol. 2017 Jun 12; 2:17083. Scott SR, Din MO, Bittihn P, Xiong L, Tsimring LS, Hasty J. PMID: 28604679.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. Suppression of Beneficial Mutations in Dynamic Microbial Populations. Phys Rev Lett. 2017 Jan 13; 118(2):028102. Bittihn P, Hasty J, Tsimring LS. PMID: 28128631.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    18. FBB: a fast Bayesian-bound tool to calibrate RNA-seq aligners. Bioinformatics. 2017 01 15; 33(2):210-218. Rodriguez-Lujan I, Hasty J, Huerta R. PMID: 27663496.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Criticality and Adaptivity in Enzymatic Networks. Biophys J. 2016 Sep 06; 111(5):1078-87. Steiner PJ, Williams RJ, Hasty J, Tsimring LS. PMID: 27602735.
      View in: PubMed   Mentions: 1     Fields:    
    20. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016 08 04; 536(7614):81-85. Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J. PMID: 27437587.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    21. Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications. Curr Opin Biotechnol. 2016 08; 40:177-184. Didovyk A, Borek B, Tsimring L, Hasty J. PMID: 27344519.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Quorum Sensing Communication Modules for Microbial Consortia. ACS Synth Biol. 2016 09 16; 5(9):969-77. Scott SR, Hasty J. PMID: 27172092.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    23. Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules. PLoS One. 2016; 11(5):e0153679. Borek B, Hasty J, Tsimring L. PMID: 27148743.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    24. Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9. ACS Synth Biol. 2016 Jan 15; 5(1):81-8. Didovyk A, Borek B, Hasty J, Tsimring L. PMID: 26390083.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    25. A Microfluidic Platform for Long-Term Monitoring of Algae in a Dynamic Environment. ACS Synth Biol. 2016 Jan 15; 5(1):8-14. Luke CS, Selimkhanov J, Baumgart L, Cohen SE, Golden SS, Cookson NA, Hasty J. PMID: 26332284.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    26. Distributed classifier based on genetically engineered bacterial cell cultures. ACS Synth Biol. 2015 Jan 16; 4(1):72-82. Didovyk A, Kanakov OI, Ivanchenko MV, Hasty J, Huerta R, Tsimring L. PMID: 25349924.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    27. Dynamic localization of the cyanobacterial circadian clock proteins. Curr Biol. 2014 Aug 18; 24(16):1836-44. Cohen SE, Erb ML, Selimkhanov J, Dong G, Hasty J, Pogliano J, Golden SS. PMID: 25127213.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    28. Rapid and tunable post-translational coupling of genetic circuits. Nature. 2014 Apr 17; 508(7496):387-91. Prindle A, Selimkhanov J, Li H, Razinkov I, Tsimring LS, Hasty J. PMID: 24717442.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    29. Measuring competitive fitness in dynamic environments. J Phys Chem B. 2013 Oct 24; 117(42):13175-81. Razinkov IA, Baumgartner BL, Bennett MR, Tsimring LS, Hasty J. PMID: 23841812.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    30. Dual delayed feedback provides sensitivity and robustness to the NF-?B signaling module. PLoS Comput Biol. 2013; 9(6):e1003112. Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. PMID: 23825938.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    31. Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture. Lab Chip. 2012 Nov 21; 12(22):4732-7. Kolnik M, Tsimring LS, Hasty J. PMID: 22961584.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Making gene circuits sing. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16758-9. Prindle A, Hasty J. PMID: 23027956.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    33. Genetic Circuits in Salmonella typhimurium. ACS Synth Biol. 2012 Oct 19; 1(10):458-464. Prindle A, Selimkhanov J, Danino T, Samayoa P, Goldberg A, Bhatia SN, Hasty J. PMID: 23097749.
      View in: PubMed   Mentions: 10     Fields:    
    34. Fast stochastic algorithm for simulating evolutionary population dynamics. Bioinformatics. 2012 May 01; 28(9):1230-8. Mather WH, Hasty J, Tsimring LS. PMID: 22437850.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Queueing up for enzymatic processing: correlated signaling through coupled degradation. Mol Syst Biol. 2011 Dec 20; 7:561. Cookson NA, Mather WH, Danino T, Mondragón-Palomino O, Williams RJ, Tsimring LS, Hasty J. PMID: 22186735.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    36. A sensing array of radically coupled genetic 'biopixels'. Nature. 2011 Dec 18; 481(7379):39-44. Prindle A, Samayoa P, Razinkov I, Danino T, Tsimring LS, Hasty J. PMID: 22178928.
      View in: PubMed   Mentions: 83     Fields:    Translation:Cells
    37. Antagonistic gene transcripts regulate adaptation to new growth environments. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21087-92. Baumgartner BL, Bennett MR, Ferry M, Johnson TL, Tsimring LS, Hasty J. PMID: 22160690.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    38. Recent advances in single-cell studies of gene regulation. Curr Opin Biotechnol. 2012 Feb; 23(1):34-40. Selimkhanov J, Hasty J, Tsimring LS. PMID: 22154220.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    39. Factorized time-dependent distributions for certain multiclass queueing networks and an application to enzymatic processing networks. Queueing Syst. 2011 Dec; 69(3-4):313-328. Mather WH, Hasty J, Tsimring LS, Williams RJ. PMID: 24596432.
      View in: PubMed   Mentions:
    40. Entrainment of a population of synthetic genetic oscillators. Science. 2011 Sep 02; 333(6047):1315-1319. Mondragón-Palomino O, Danino T, Selimkhanov J, Tsimring L, Hasty J. PMID: 21885786.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    41. In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS One. 2011; 6(5):e20182. Danino T, Volfson D, Bhatia SN, Tsimring L, Hasty J. PMID: 21633504.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    42. Microfluidics for synthetic biology: from design to execution. Methods Enzymol. 2011; 497:295-372. Ferry MS, Razinkov IA, Hasty J. PMID: 21601093.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    43. Correlation resonance generated by coupled enzymatic processing. Biophys J. 2010 Nov 17; 99(10):3172-81. Mather WH, Cookson NA, Hasty J, Tsimring LS, Williams RJ. PMID: 21081064.
      View in: PubMed   Mentions: 13     Fields:    
    44. Biochemistry. Stochastic emergence of groupthink. Science. 2010 May 21; 328(5981):987-8. Prindle A, Hasty J. PMID: 20489014.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. Streaming instability in growing cell populations. Phys Rev Lett. 2010 May 21; 104(20):208101. Mather W, Mondragón-Palomino O, Danino T, Hasty J, Tsimring LS. PMID: 20867071.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    46. A synchronized quorum of genetic clocks. Nature. 2010 Jan 21; 463(7279):326-30. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J. PMID: 20090747.
      View in: PubMed   Mentions: 213     Fields:    Translation:Cells
    47. The pedestrian watchmaker: genetic clocks from engineered oscillators. FEBS Lett. 2009 Dec 17; 583(24):3931-7. Cookson NA, Tsimring LS, Hasty J. PMID: 19903483.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    48. Cell cycle-dependent variations in protein concentration. Nucleic Acids Res. 2010 May; 38(8):2676-81. Cookson NA, Cookson SW, Tsimring LS, Hasty J. PMID: 20019065.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    49. Delay-induced degrade-and-fire oscillations in small genetic circuits. Phys Rev Lett. 2009 Feb 13; 102(6):068105. Mather W, Bennett MR, Hasty J, Tsimring LS. PMID: 19257639.
      View in: PubMed   Mentions: 45     Fields:    
    50. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27; 456(7221):516-9. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. PMID: 18971928.
      View in: PubMed   Mentions: 307     Fields:    Translation:Cells
    51. Biomechanical ordering of dense cell populations. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15346-51. Volfson D, Cookson S, Hasty J, Tsimring LS. PMID: 18832176.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    52. Metabolic gene regulation in a dynamically changing environment. Nature. 2008 Aug 28; 454(7208):1119-22. Bennett MR, Pang WL, Ostroff NA, Baumgartner BL, Nayak S, Tsimring LS, Hasty J. PMID: 18668041.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    53. Phenotypic variability of growing cellular populations. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18982-7. Lu T, Shen T, Bennett MR, Wolynes PG, Hasty J. PMID: 18025471.
      View in: PubMed   Mentions: 13     Fields:    
    54. A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol Syst Biol. 2007; 3:127. Grilly C, Stricker J, Pang WL, Bennett MR, Hasty J. PMID: 17667949.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    55. Transient dynamics of genetic regulatory networks. Biophys J. 2007 May 15; 92(10):3501-12. Bennett MR, Volfson D, Tsimring L, Hasty J. PMID: 17350994.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    56. Dynamics of single-cell gene expression. Mol Syst Biol. 2006; 2:64. Longo D, Hasty J. PMID: 17130866.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    57. Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16752-7. Lu T, Shen T, Zong C, Hasty J, Wolynes PG. PMID: 17071742.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    58. Stochastically driven genetic circuits. Chaos. 2006 Jun; 16(2):026103. Tsimring LS, Volfson D, Hasty J. PMID: 16822035.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    59. Effective temperature in stochastic kinetics and gene networks. Biophys J. 2006 Jul 01; 91(1):84-94. Lu T, Hasty J, Wolynes PG. PMID: 16617067.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    60. Origins of extrinsic variability in eukaryotic gene expression. Nature. 2006 Feb 16; 439(7078):861-4. Volfson D, Marciniak J, Blake WJ, Ostroff N, Tsimring LS, Hasty J. PMID: 16372021.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    61. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol Syst Biol. 2005; 1:2005.0024. Cookson S, Ostroff N, Pang WL, Volfson D, Hasty J. PMID: 16729059.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    62. Delay-induced stochastic oscillations in gene regulation. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14593-8. Bratsun D, Volfson D, Tsimring LS, Hasty J. PMID: 16199522.
      View in: PubMed   Mentions: 85     Fields:    
    63. Cellular growth and division in the Gillespie algorithm. Syst Biol (Stevenage). 2004 Jun; 1(1):121-8. Lu T, Volfson D, Tsimring L, Hasty J. PMID: 17052122.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    64. Design then mutate. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16516-8. Hasty J. PMID: 12486244.
      View in: PubMed   Mentions:    Fields:    
    65. Engineered gene circuits. Nature. 2002 Nov 14; 420(6912):224-30. Hasty J, McMillen D, Collins JJ. PMID: 12432407.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
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