Jeff Hasty

InstitutionUniversity of California San Diego
DepartmentMolecular Biology
Address9500 Gilman Drive #0368
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Network-Driven Dynamics of Replicative Aging
    NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    The q-bio Summer School
    NIH/NIGMS R25GM105608Apr 1, 2013 - Jan 31, 2017
    Role: Principal Investigator
    Delays and variability in single-cell NFkB signaling
    NIH/NIGMS R01GM089976May 1, 2010 - Apr 30, 2014
    Role: Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
    Role: Principal Investigator
    Metabolic Control in a Dynamic Environment
    NIH/NIGMS R01GM079333Dec 1, 2006 - Apr 30, 2015
    Role: Principal Investigator
    Engineered gene circuits for basic science and biotechnology
    NIH/NIGMS R01GM069811Dec 1, 2003 - Jul 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bittihn P, Din MO, Tsimring LS, Hasty J. Rational engineering of synthetic microbial systems: from single cells to consortia. Curr Opin Microbiol. 2018 Mar 22; 45:92-99. PMID: 29574330.
      View in: PubMed
    2. Cooper RM, Tsimring L, Hasty J. Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance. Elife. 2017 Nov 01; 6. PMID: 29091031.
      View in: PubMed
    3. Li Y, Jin M, O'Laughlin R, Bittihn P, Tsimring LS, Pillus L, Hasty J, Hao N. Multigenerational silencing dynamics control cell aging. Proc Natl Acad Sci U S A. 2017 Oct 17; 114(42):11253-11258. PMID: 29073021.
      View in: PubMed
    4. Didovyk A, Tonooka T, Tsimring L, Hasty J. Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression. ACS Synth Biol. 2017 12 15; 6(12):2198-2208. PMID: 28795570.
      View in: PubMed
    5. Baumgart L, Mather W, Hasty J. Synchronized DNA cycling across a bacterial population. Nat Genet. 2017 Aug; 49(8):1282-1285. PMID: 28692067.
      View in: PubMed
    6. Scott SR, Din MO, Bittihn P, Xiong L, Tsimring LS, Hasty J. A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis. Nat Microbiol. 2017 Jun 12; 2:17083. PMID: 28604679.
      View in: PubMed
    7. Bittihn P, Hasty J, Tsimring LS. Suppression of Beneficial Mutations in Dynamic Microbial Populations. Phys Rev Lett. 2017 Jan 13; 118(2):028102. PMID: 28128631.
      View in: PubMed
    8. Rodriguez-Lujan I, Hasty J, Huerta R. FBB: a fast Bayesian-bound tool to calibrate RNA-seq aligners. Bioinformatics. 2017 01 15; 33(2):210-218. PMID: 27663496.
      View in: PubMed
    9. Steiner PJ, Williams RJ, Hasty J, Tsimring LS. Criticality and Adaptivity in Enzymatic Networks. Biophys J. 2016 Sep 06; 111(5):1078-87. PMID: 27602735.
      View in: PubMed
    10. Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016 08 04; 536(7614):81-85. PMID: 27437587.
      View in: PubMed
    11. Didovyk A, Borek B, Tsimring L, Hasty J. Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications. Curr Opin Biotechnol. 2016 08; 40:177-184. PMID: 27344519.
      View in: PubMed
    12. Scott SR, Hasty J. Quorum Sensing Communication Modules for Microbial Consortia. ACS Synth Biol. 2016 09 16; 5(9):969-77. PMID: 27172092.
      View in: PubMed
    13. Borek B, Hasty J, Tsimring L. Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules. PLoS One. 2016; 11(5):e0153679. PMID: 27148743; PMCID: PMC4858293.
    14. Didovyk A, Borek B, Hasty J, Tsimring L. Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9. ACS Synth Biol. 2016 Jan 15; 5(1):81-8. PMID: 26390083.
      View in: PubMed
    15. Luke CS, Selimkhanov J, Baumgart L, Cohen SE, Golden SS, Cookson NA, Hasty J. A Microfluidic Platform for Long-Term Monitoring of Algae in a Dynamic Environment. ACS Synth Biol. 2016 Jan 15; 5(1):8-14. PMID: 26332284.
      View in: PubMed
    16. Didovyk A, Kanakov OI, Ivanchenko MV, Hasty J, Huerta R, Tsimring L. Distributed classifier based on genetically engineered bacterial cell cultures. ACS Synth Biol. 2015 Jan 16; 4(1):72-82. PMID: 25349924; PMCID: PMC4304444.
    17. Cohen SE, Erb ML, Selimkhanov J, Dong G, Hasty J, Pogliano J, Golden SS. Dynamic localization of the cyanobacterial circadian clock proteins. Curr Biol. 2014 Aug 18; 24(16):1836-44. PMID: 25127213; PMCID: PMC4139467.
    18. Prindle A, Selimkhanov J, Li H, Razinkov I, Tsimring LS, Hasty J. Rapid and tunable post-translational coupling of genetic circuits. Nature. 2014 Apr 17; 508(7496):387-91. PMID: 24717442; PMCID: PMC4142690.
    19. Razinkov IA, Baumgartner BL, Bennett MR, Tsimring LS, Hasty J. Measuring competitive fitness in dynamic environments. J Phys Chem B. 2013 Oct 24; 117(42):13175-81. PMID: 23841812; PMCID: PMC3808460.
    20. Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. Dual delayed feedback provides sensitivity and robustness to the NF-?B signaling module. PLoS Comput Biol. 2013; 9(6):e1003112. PMID: 23825938; PMCID: PMC3694842.
    21. Kolnik M, Tsimring LS, Hasty J. Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture. Lab Chip. 2012 Nov 21; 12(22):4732-7. PMID: 22961584; PMCID: PMC3510264.
    22. Prindle A, Hasty J. Making gene circuits sing. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16758-9. PMID: 23027956; PMCID: PMC3479459.
    23. Prindle A, Selimkhanov J, Danino T, Samayoa P, Goldberg A, Bhatia SN, Hasty J. Genetic Circuits in Salmonella typhimurium. ACS Synth Biol. 2012 Oct 19; 1(10):458-464. PMID: 23097749.
      View in: PubMed
    24. Mather WH, Hasty J, Tsimring LS. Fast stochastic algorithm for simulating evolutionary population dynamics. Bioinformatics. 2012 May 01; 28(9):1230-8. PMID: 22437850; PMCID: PMC3338019.
    25. Cookson NA, Mather WH, Danino T, Mondragón-Palomino O, Williams RJ, Tsimring LS, Hasty J. Queueing up for enzymatic processing: correlated signaling through coupled degradation. Mol Syst Biol. 2011 Dec 20; 7:561. PMID: 22186735; PMCID: PMC3737734.
    26. Prindle A, Samayoa P, Razinkov I, Danino T, Tsimring LS, Hasty J. A sensing array of radically coupled genetic 'biopixels'. Nature. 2011 Dec 18; 481(7379):39-44. PMID: 22178928; PMCID: PMC3259005.
    27. Baumgartner BL, Bennett MR, Ferry M, Johnson TL, Tsimring LS, Hasty J. Antagonistic gene transcripts regulate adaptation to new growth environments. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21087-92. PMID: 22160690; PMCID: PMC3248483.
    28. Selimkhanov J, Hasty J, Tsimring LS. Recent advances in single-cell studies of gene regulation. Curr Opin Biotechnol. 2012 Feb; 23(1):34-40. PMID: 22154220; PMCID: PMC3273644.
    29. Mondragón-Palomino O, Danino T, Selimkhanov J, Tsimring L, Hasty J. Entrainment of a population of synthetic genetic oscillators. Science. 2011 Sep 02; 333(6047):1315-1319. PMID: 21885786; PMCID: PMC4841678.
    30. Danino T, Volfson D, Bhatia SN, Tsimring L, Hasty J. In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS One. 2011; 6(5):e20182. PMID: 21633504; PMCID: PMC3102094.
    31. Mather WH, Cookson NA, Hasty J, Tsimring LS, Williams RJ. Correlation resonance generated by coupled enzymatic processing. Biophys J. 2010 Nov 17; 99(10):3172-81. PMID: 21081064; PMCID: PMC2980735.
    32. Prindle A, Hasty J. Biochemistry. Stochastic emergence of groupthink. Science. 2010 May 21; 328(5981):987-8. PMID: 20489014; PMCID: PMC2931587.
    33. Mather W, Mondragón-Palomino O, Danino T, Hasty J, Tsimring LS. Streaming instability in growing cell populations. Phys Rev Lett. 2010 May 21; 104(20):208101. PMID: 20867071; PMCID: PMC2947335.
    34. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J. A synchronized quorum of genetic clocks. Nature. 2010 Jan 21; 463(7279):326-30. PMID: 20090747; PMCID: PMC2838179.
    35. Cookson NA, Cookson SW, Tsimring LS, Hasty J. Cell cycle-dependent variations in protein concentration. Nucleic Acids Res. 2010 May; 38(8):2676-81. PMID: 20019065; PMCID: PMC2860113.
    36. Cookson NA, Tsimring LS, Hasty J. The pedestrian watchmaker: genetic clocks from engineered oscillators. FEBS Lett. 2009 Dec 17; 583(24):3931-7. PMID: 19903483; PMCID: PMC2921805.
    37. Mather W, Bennett MR, Hasty J, Tsimring LS. Delay-induced degrade-and-fire oscillations in small genetic circuits. Phys Rev Lett. 2009 Feb 13; 102(6):068105. PMID: 19257639; PMCID: PMC2924583.
    38. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27; 456(7221):516-9. PMID: 18971928.
      View in: PubMed
    39. Volfson D, Cookson S, Hasty J, Tsimring LS. Biomechanical ordering of dense cell populations. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15346-51. PMID: 18832176; PMCID: PMC2563119.
    40. Bennett MR, Pang WL, Ostroff NA, Baumgartner BL, Nayak S, Tsimring LS, Hasty J. Metabolic gene regulation in a dynamically changing environment. Nature. 2008 Aug 28; 454(7208):1119-22. PMID: 18668041; PMCID: PMC2654342.
    41. Lu T, Shen T, Bennett MR, Wolynes PG, Hasty J. Phenotypic variability of growing cellular populations. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18982-7. PMID: 18025471; PMCID: PMC2141894.
    42. Grilly C, Stricker J, Pang WL, Bennett MR, Hasty J. A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol Syst Biol. 2007; 3:127. PMID: 17667949; PMCID: PMC1943424.
    43. Bennett MR, Volfson D, Tsimring L, Hasty J. Transient dynamics of genetic regulatory networks. Biophys J. 2007 May 15; 92(10):3501-12. PMID: 17350994; PMCID: PMC1853127.
    44. Longo D, Hasty J. Dynamics of single-cell gene expression. Mol Syst Biol. 2006; 2:64. PMID: 17130866; PMCID: PMC1682029.
    45. Lu T, Shen T, Zong C, Hasty J, Wolynes PG. Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16752-7. PMID: 17071742; PMCID: PMC1636527.
    46. Lu T, Hasty J, Wolynes PG. Effective temperature in stochastic kinetics and gene networks. Biophys J. 2006 Jul 01; 91(1):84-94. PMID: 16617067; PMCID: PMC1479063.
    47. Volfson D, Marciniak J, Blake WJ, Ostroff N, Tsimring LS, Hasty J. Origins of extrinsic variability in eukaryotic gene expression. Nature. 2006 Feb 16; 439(7078):861-4. PMID: 16372021.
      View in: PubMed
    48. Cookson S, Ostroff N, Pang WL, Volfson D, Hasty J. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol Syst Biol. 2005; 1:2005.0024. PMID: 16729059; PMCID: PMC1681470.
    49. Bratsun D, Volfson D, Tsimring LS, Hasty J. Delay-induced stochastic oscillations in gene regulation. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14593-8. PMID: 16199522; PMCID: PMC1253555.
    50. Hasty J. Design then mutate. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16516-8. PMID: 12486244; PMCID: PMC139174.
    51. Hasty J, McMillen D, Collins JJ. Engineered gene circuits. Nature. 2002 Nov 14; 420(6912):224-30. PMID: 12432407.
      View in: PubMed
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