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    Jeff Hasty

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0368
    CA La Jolla 92093
    Phone858-822-3442
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      Collapse Research 
      Collapse Research Activities and Funding
      Network-Driven Dynamics of Replicative Aging
      NIH/NIA R01AG056440Aug 1, 2017 - May 31, 2022
      Role: Co-Principal Investigator
      The q-bio Summer School
      NIH/NIGMS R25GM105608Apr 1, 2013 - Jan 31, 2017
      Role: Principal Investigator
      Delays and variability in single-cell NFkB signaling
      NIH/NIGMS R01GM089976May 1, 2010 - Apr 30, 2014
      Role: Principal Investigator
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Principal Investigator
      Metabolic Control in a Dynamic Environment
      NIH/NIGMS R01GM079333Dec 1, 2006 - Apr 30, 2015
      Role: Principal Investigator
      Engineered gene circuits for basic science and biotechnology
      NIH/NIGMS R01GM069811Dec 1, 2003 - Jul 31, 2020
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Didovyk A, Tonooka T, Tsimring L, Hasty J. Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression. ACS Synth Biol. 2017 Aug 21. PMID: 28795570.
        View in: PubMed
      2. Baumgart L, Mather W, Hasty J. Synchronized DNA cycling across a bacterial population. Nat Genet. 2017 Aug; 49(8):1282-1285. PMID: 28692067.
        View in: PubMed
      3. Scott SR, Din MO, Bittihn P, Xiong L, Tsimring LS, Hasty J. A stabilized microbial ecosystem of self-limiting bacteria using synthetic quorum-regulated lysis. Nat Microbiol. 2017 Jun 12; 2:17083. PMID: 28604679.
        View in: PubMed
      4. Bittihn P, Hasty J, Tsimring LS. Suppression of Beneficial Mutations in Dynamic Microbial Populations. Phys Rev Lett. 2017 Jan 13; 118(2):028102. PMID: 28128631.
        View in: PubMed
      5. Rodriguez-Lujan I, Hasty J, Huerta R. FBB: a fast Bayesian-bound tool to calibrate RNA-seq aligners. Bioinformatics. 2017 Jan 15; 33(2):210-218. PMID: 27663496.
        View in: PubMed
      6. Steiner PJ, Williams RJ, Hasty J, Tsimring LS. Criticality and Adaptivity in Enzymatic Networks. Biophys J. 2016 Sep 06; 111(5):1078-87. PMID: 27602735.
        View in: PubMed
      7. Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016 Aug 4; 536(7614):81-5. PMID: 27437587.
        View in: PubMed
      8. Didovyk A, Borek B, Tsimring L, Hasty J. Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications. Curr Opin Biotechnol. 2016 Aug; 40:177-184. PMID: 27344519; PMCID: PMC4975649 [Available on 08/01/17].
        View in: PubMed, PubMed Central
      9. Scott SR, Hasty J. Quorum Sensing Communication Modules for Microbial Consortia. ACS Synth Biol. 2016 Sep 16; 5(9):969-77. PMID: 27172092.
        View in: PubMed
      10. Borek B, Hasty J, Tsimring L. Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules. PLoS One. 2016; 11(5):e0153679. PMID: 27148743; PMCID: PMC4858293.
        View in: PubMed, PubMed Central
      11. Didovyk A, Borek B, Hasty J, Tsimring L. Orthogonal Modular Gene Repression in Escherichia coli Using Engineered CRISPR/Cas9. ACS Synth Biol. 2016 Jan 15; 5(1):81-8. PMID: 26390083.
        View in: PubMed
      12. Luke CS, Selimkhanov J, Baumgart L, Cohen SE, Golden SS, Cookson NA, Hasty J. A Microfluidic Platform for Long-Term Monitoring of Algae in a Dynamic Environment. ACS Synth Biol. 2016 Jan 15; 5(1):8-14. PMID: 26332284.
        View in: PubMed
      13. Didovyk A, Kanakov OI, Ivanchenko MV, Hasty J, Huerta R, Tsimring L. Distributed classifier based on genetically engineered bacterial cell cultures. ACS Synth Biol. 2015 Jan 16; 4(1):72-82. PMID: 25349924; PMCID: PMC4304444.
        View in: PubMed, PubMed Central
      14. Cohen SE, Erb ML, Selimkhanov J, Dong G, Hasty J, Pogliano J, Golden SS. Dynamic localization of the cyanobacterial circadian clock proteins. Curr Biol. 2014 Aug 18; 24(16):1836-44. PMID: 25127213; PMCID: PMC4139467.
        View in: PubMed, PubMed Central
      15. Prindle A, Selimkhanov J, Li H, Razinkov I, Tsimring LS, Hasty J. Rapid and tunable post-translational coupling of genetic circuits. Nature. 2014 Apr 17; 508(7496):387-91. PMID: 24717442; PMCID: PMC4142690.
        View in: PubMed, PubMed Central
      16. Razinkov IA, Baumgartner BL, Bennett MR, Tsimring LS, Hasty J. Measuring competitive fitness in dynamic environments. J Phys Chem B. 2013 Oct 24; 117(42):13175-81. PMID: 23841812; PMCID: PMC3808460.
        View in: PubMed, PubMed Central
      17. Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS. Dual delayed feedback provides sensitivity and robustness to the NF-?B signaling module. PLoS Comput Biol. 2013; 9(6):e1003112. PMID: 23825938; PMCID: PMC3694842.
        View in: PubMed, PubMed Central
      18. Kolnik M, Tsimring LS, Hasty J. Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture. Lab Chip. 2012 Nov 21; 12(22):4732-7. PMID: 22961584; PMCID: PMC3510264.
        View in: PubMed, PubMed Central
      19. Prindle A, Hasty J. Making gene circuits sing. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):16758-9. PMID: 23027956; PMCID: PMC3479459.
        View in: PubMed, PubMed Central
      20. Prindle A, Selimkhanov J, Danino T, Samayoa P, Goldberg A, Bhatia SN, Hasty J. Genetic Circuits in Salmonella typhimurium. ACS Synth Biol. 2012 Oct 19; 1(10):458-464. PMID: 23097749.
        View in: PubMed
      21. Mather WH, Hasty J, Tsimring LS. Fast stochastic algorithm for simulating evolutionary population dynamics. Bioinformatics. 2012 May 01; 28(9):1230-8. PMID: 22437850; PMCID: PMC3338019.
        View in: PubMed, PubMed Central
      22. Cookson NA, Mather WH, Danino T, Mondragón-Palomino O, Williams RJ, Tsimring LS, Hasty J. Queueing up for enzymatic processing: correlated signaling through coupled degradation. Mol Syst Biol. 2011 Dec 20; 7:561. PMID: 22186735; PMCID: PMC3737734.
        View in: PubMed, PubMed Central
      23. Prindle A, Samayoa P, Razinkov I, Danino T, Tsimring LS, Hasty J. A sensing array of radically coupled genetic 'biopixels'. Nature. 2011 Dec 18; 481(7379):39-44. PMID: 22178928; PMCID: PMC3259005.
        View in: PubMed, PubMed Central
      24. Baumgartner BL, Bennett MR, Ferry M, Johnson TL, Tsimring LS, Hasty J. Antagonistic gene transcripts regulate adaptation to new growth environments. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21087-92. PMID: 22160690; PMCID: PMC3248483.
        View in: PubMed, PubMed Central
      25. Selimkhanov J, Hasty J, Tsimring LS. Recent advances in single-cell studies of gene regulation. Curr Opin Biotechnol. 2012 Feb; 23(1):34-40. PMID: 22154220; PMCID: PMC3273644.
        View in: PubMed, PubMed Central
      26. Mather WH, Hasty J, Tsimring LS, Williams RJ. Factorized time-dependent distributions for certain multiclass queueing networks and an application to enzymatic processing networks. Queueing Syst. 2011 Dec; 69(3-4):313-328. PMID: 24596432.
        View in: PubMed
      27. Mondragón-Palomino O, Danino T, Selimkhanov J, Tsimring L, Hasty J. Entrainment of a population of synthetic genetic oscillators. Science. 2011 Sep 2; 333(6047):1315-9. PMID: 21885786.
        View in: PubMed
      28. Danino T, Volfson D, Bhatia SN, Tsimring L, Hasty J. In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS One. 2011; 6(5):e20182. PMID: 21633504; PMCID: PMC3102094.
        View in: PubMed, PubMed Central
      29. Ferry MS, Razinkov IA, Hasty J. Microfluidics for synthetic biology: from design to execution. Methods Enzymol. 2011; 497:295-372. PMID: 21601093; PMCID: PMC4836382.
        View in: PubMed, PubMed Central
      30. Mather WH, Cookson NA, Hasty J, Tsimring LS, Williams RJ. Correlation resonance generated by coupled enzymatic processing. Biophys J. 2010 Nov 17; 99(10):3172-81. PMID: 21081064; PMCID: PMC2980735.
        View in: PubMed, PubMed Central
      31. Prindle A, Hasty J. Biochemistry. Stochastic emergence of groupthink. Science. 2010 May 21; 328(5981):987-8. PMID: 20489014; PMCID: PMC2931587.
        View in: PubMed, PubMed Central
      32. Mather W, Mondragón-Palomino O, Danino T, Hasty J, Tsimring LS. Streaming instability in growing cell populations. Phys Rev Lett. 2010 May 21; 104(20):208101. PMID: 20867071; PMCID: PMC2947335.
        View in: PubMed, PubMed Central
      33. Danino T, Mondragón-Palomino O, Tsimring L, Hasty J. A synchronized quorum of genetic clocks. Nature. 2010 Jan 21; 463(7279):326-30. PMID: 20090747; PMCID: PMC2838179.
        View in: PubMed, PubMed Central
      34. Cookson NA, Tsimring LS, Hasty J. The pedestrian watchmaker: genetic clocks from engineered oscillators. FEBS Lett. 2009 Dec 17; 583(24):3931-7. PMID: 19903483; PMCID: PMC2921805.
        View in: PubMed, PubMed Central
      35. Cookson NA, Cookson SW, Tsimring LS, Hasty J. Cell cycle-dependent variations in protein concentration. Nucleic Acids Res. 2010 May; 38(8):2676-81. PMID: 20019065; PMCID: PMC2860113.
        View in: PubMed, PubMed Central
      36. Mather W, Bennett MR, Hasty J, Tsimring LS. Delay-induced degrade-and-fire oscillations in small genetic circuits. Phys Rev Lett. 2009 Feb 13; 102(6):068105. PMID: 19257639; PMCID: PMC2924583.
        View in: PubMed, PubMed Central
      37. Stricker J, Cookson S, Bennett MR, Mather WH, Tsimring LS, Hasty J. A fast, robust and tunable synthetic gene oscillator. Nature. 2008 Nov 27; 456(7221):516-9. PMID: 18971928.
        View in: PubMed
      38. Volfson D, Cookson S, Hasty J, Tsimring LS. Biomechanical ordering of dense cell populations. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15346-51. PMID: 18832176; PMCID: PMC2563119.
        View in: PubMed, PubMed Central
      39. Bennett MR, Pang WL, Ostroff NA, Baumgartner BL, Nayak S, Tsimring LS, Hasty J. Metabolic gene regulation in a dynamically changing environment. Nature. 2008 Aug 28; 454(7208):1119-22. PMID: 18668041; PMCID: PMC2654342.
        View in: PubMed, PubMed Central
      40. Lu T, Shen T, Bennett MR, Wolynes PG, Hasty J. Phenotypic variability of growing cellular populations. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18982-7. PMID: 18025471; PMCID: PMC2141894.
        View in: PubMed, PubMed Central
      41. Grilly C, Stricker J, Pang WL, Bennett MR, Hasty J. A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol Syst Biol. 2007; 3:127. PMID: 17667949; PMCID: PMC1943424.
        View in: PubMed, PubMed Central
      42. Bennett MR, Volfson D, Tsimring L, Hasty J. Transient dynamics of genetic regulatory networks. Biophys J. 2007 May 15; 92(10):3501-12. PMID: 17350994; PMCID: PMC1853127.
        View in: PubMed, PubMed Central
      43. Longo D, Hasty J. Dynamics of single-cell gene expression. Mol Syst Biol. 2006; 2:64. PMID: 17130866; PMCID: PMC1682029.
        View in: PubMed, PubMed Central
      44. Lu T, Shen T, Zong C, Hasty J, Wolynes PG. Statistics of cellular signal transduction as a race to the nucleus by multiple random walkers in compartment/phosphorylation space. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16752-7. PMID: 17071742; PMCID: PMC1636527.
        View in: PubMed, PubMed Central
      45. Tsimring LS, Volfson D, Hasty J. Stochastically driven genetic circuits. Chaos. 2006 Jun; 16(2):026103. PMID: 16822035.
        View in: PubMed
      46. Lu T, Hasty J, Wolynes PG. Effective temperature in stochastic kinetics and gene networks. Biophys J. 2006 Jul 01; 91(1):84-94. PMID: 16617067; PMCID: PMC1479063.
        View in: PubMed, PubMed Central
      47. Volfson D, Marciniak J, Blake WJ, Ostroff N, Tsimring LS, Hasty J. Origins of extrinsic variability in eukaryotic gene expression. Nature. 2006 Feb 16; 439(7078):861-4. PMID: 16372021.
        View in: PubMed
      48. Cookson S, Ostroff N, Pang WL, Volfson D, Hasty J. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol Syst Biol. 2005; 1:2005.0024. PMID: 16729059; PMCID: PMC1681470.
        View in: PubMed, PubMed Central
      49. Bratsun D, Volfson D, Tsimring LS, Hasty J. Delay-induced stochastic oscillations in gene regulation. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14593-8. PMID: 16199522; PMCID: PMC1253555.
        View in: PubMed, PubMed Central
      50. Lu T, Volfson D, Tsimring L, Hasty J. Cellular growth and division in the Gillespie algorithm. Syst Biol (Stevenage). 2004 Jun; 1(1):121-8. PMID: 17052122.
        View in: PubMed
      51. Hasty J. Design then mutate. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16516-8. PMID: 12486244; PMCID: PMC139174.
        View in: PubMed, PubMed Central
      52. Hasty J, McMillen D, Collins JJ. Engineered gene circuits. Nature. 2002 Nov 14; 420(6912):224-30. PMID: 12432407.
        View in: PubMed
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