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Christopher Glass

Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Dr. Glass’ primary interests are to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages. A major direction of his laboratory has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing. The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to inflammatory diseases that include diabetes, atherosclerosis and neurodegenerative diseases.

    Research Focus Areas:


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    Defining the cell-specific epigenetic landscape leading to altered gene expression signatures in HIV-Associated Neurocognitive Disorder
    NIH/NIA RF1AG061060Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    The Enhancer Code of AD-A Genetic Approach
    NIH/NIA R01AG056511Aug 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease
    NIH/NIA R01AG057706Sep 30, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Mechanisms controlling human microglia gene expression
    NIH/NINDS R01NS096170May 15, 2016 - Apr 30, 2021
    Role: Principal Investigator
    Enhancer Therapy
    NIH/NCI R01CA173903Sep 12, 2012 - Jul 31, 2017
    Role: Principal Investigator
    San Diego Center for Systems Biology: From Maps to Models
    NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
    Role: Co-Investigator
    PPARgamma, Toll-like receptors, and atherosclerosis
    NIH/NHLBI R01HL088129May 1, 2007 - Apr 30, 2008
    Role: Principal Investigator
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH/NHLBI P01HL088093Apr 1, 2007 - Mar 31, 2014
    Role: Co-Investigator
    Gene Networks controlling macrophage-adipocyte interactions in insulin
    NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
    Role: Principal Investigator
    Conference on PPAR/LXR
    NIH/NIDDK R13DK070428Sep 20, 2004 - Aug 31, 2005
    Role: Principal Investigator
    LIPID MAPS
    NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
    Role: Co-Investigator
    Diabetes Research Center (DRC)
    NIH/NIDDK P30DK063491Dec 1, 2002 - Nov 30, 2007
    Role: Co-Investigator
    Nuclear Receptors and Coregulators in Health and Disease
    NIH U19DK062434Aug 15, 2002 - Jul 31, 2012
    Role: Co-Investigator
    Gordon Research Conference: Mechanisms of Hormone Action
    NIH/NIDDK R13DK061960Jun 15, 2002 - May 31, 2005
    Role: Principal Investigator
    Summer Undergraduate Research Fellowship (SURF)
    NIH/NHLBI T35HL067694May 21, 2001 - Apr 30, 2006
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    CDNA MICROARRAYER AND SCANNING CONFOCAL LASER READER
    NIH/NCRR S10RR014881Apr 1, 2000 - Mar 31, 2001
    Role: Principal Investigator
    SCOR in Molecular Medicine and Atherosclerosis
    NIH/NHLBI P50HL056989Apr 1, 1998 - Mar 31, 2008
    Role: Co-Investigator
    Integration of transcriptional responses in macrophages
    NIH/NHLBI R01HL059694Jan 1, 1998 - Dec 31, 2008
    Role: Principal Investigator
    Transcriptional co-regulators and macrophage gene expression
    NIH/NIDDK R01DK091183Apr 1, 1991 - Jan 31, 2025
    Role: Principal Investigator
    Transcriptional Co-Regulators and Macrophage Gene Expression
    NIH/NCI R01CA052599Apr 1, 1991 - Mar 31, 2011
    Role: Principal Investigator
    CELL-SPECIFIC EXPRESSION OF GROWTH HORMONE AND PROLACTIN
    NIH/NIDDK F32DK007959Mar 1, 1987
    Role: Principal Investigator
    TRAINING GRANT IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    NIH/NHLBI T32HL007276Jul 1, 1977 - Nov 12, 2005
    Role: Principal Investigator
    SCOR IN ARTERIOSCLEROSIS
    NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Going nuclear in metabolic and cardiovascular disease. J Clin Invest. 2006 Mar; 116(3):556-60. Glass CK. PMID: 16511587.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    2. The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. Mol Cell. 2004 Feb 27; 13(4):459-67. Glass CK, McDonnell DP. PMID: 14992717.
      View in: PubMed   Mentions:    Fields:    
    3. Potential roles of the peroxisome proliferator-activated receptor-gamma in macrophage biology and atherosclerosis. J Endocrinol. 2001 Jun; 169(3):461-4. Glass CK. PMID: 11375116.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    4. Atherosclerosis. the road ahead. Cell. 2001 Feb 23; 104(4):503-16. Glass CK, Witztum JL. PMID: 11239408.
      View in: PubMed   Mentions: 697     Fields:    Translation:HumansAnimalsCells
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