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    Christopher Glass

    Address9500 Gilman Drive #0651
    CA La Jolla 92093
    Phone858-534-6011
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Glass’ primary interests are to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages. A major direction of his laboratory has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing. The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to inflammatory diseases that include diabetes, atherosclerosis and neurodegenerative diseases.

      Research Focus Areas:



      Collapse Research 
      Collapse Research Activities and Funding
      Mechanisms controlling human microglia gene expression
      NIH/NINDS R01NS096170May 15, 2016 - Apr 30, 2021
      Role: Principal Investigator
      Enhancer Therapy
      NIH/NCI R01CA173903Sep 12, 2012 - Jul 31, 2017
      Role: Principal Investigator
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Co-Investigator
      PPARgamma, Toll-like receptors, and atherosclerosis
      NIH/NHLBI R01HL088129May 1, 2007 - Apr 30, 2008
      Role: Principal Investigator
      Role of Immune Mechanisms in Athersclerosis and Inflammation
      NIH/NHLBI P01HL088093Apr 1, 2007 - Apr 30, 2019
      Role: Co-Investigator
      Gene Networks controlling macrophage-adipocyte interactions in insulin
      NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
      Role: Principal Investigator
      Conference on PPAR/LXR
      NIH/NIDDK R13DK070428Sep 20, 2004 - Aug 31, 2005
      Role: Principal Investigator
      LIPID MAPS
      NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
      Role: Co-Investigator
      Diabetes Research Center (DRC)
      NIH/NIDDK P30DK063491Dec 1, 2002 - Apr 30, 2018
      Role: Co-Investigator
      Nuclear Receptors and Coregulators in Health and Disease
      NIH U19DK062434Aug 15, 2002 - Jul 31, 2012
      Role: Co-Investigator
      Gordon Research Conference: Mechanisms of Hormone Action
      NIH/NIDDK R13DK061960Jun 15, 2002 - Jul 31, 2005
      Role: Principal Investigator
      Summer Undergraduate Research Fellowship (SURF)
      NIH/NHLBI T35HL067694May 21, 2001 - Apr 30, 2006
      Role: Principal Investigator
      DETECTION AND MODELS OF TOXICANT EXPOSURE
      NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
      Role: Co-Investigator
      CDNA MICROARRAYER AND SCANNING CONFOCAL LASER READER
      NIH/NCRR S10RR014881Apr 1, 2000 - Mar 31, 2001
      Role: Principal Investigator
      Integration of transcriptional responses in macrophages
      NIH/NHLBI R01HL059694Jan 1, 1998 - Dec 31, 2008
      Role: Principal Investigator
      SCOR in Molecular Medicine and Atherosclerosis
      NIH/NHLBI P50HL056989Apr 23, 1997 - Mar 31, 2008
      Role: Co-Investigator
      Transcriptional co-regulators and macrophage gene expression
      NIH/NIDDK R01DK091183Apr 1, 1991 - Jan 31, 2020
      Role: Principal Investigator
      Transcriptional Co-Regulators and Macrophage Gene Expression
      NIH/NCI R01CA052599Apr 1, 1991 - Mar 31, 2011
      Role: Principal Investigator
      CELL-SPECIFIC EXPRESSION OF GROWTH HORMONE AND PROLACTIN
      NIH/NIDDK F32DK007959Mar 1, 1987
      Role: Principal Investigator
      TRAINING GRANT IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
      NIH/NHLBI T32HL007276Jul 1, 1977 - Nov 12, 2005
      Role: Principal Investigator
      SCOR IN ARTERIOSCLEROSIS
      NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
      Role: Co-Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Holtman IR, Skola D, Glass C. Transcriptional control of microglia phenotypes in health and disease. J Clin Invest. 2017 Sep 01; 127(9):3220-3229. PMID: 28758903.
        View in: PubMed
      2. Hogan NT, Whalen MB, Stolze LK, Hadeli NK, Lam MT, Springstead JR, Glass C, Romanoski CE. Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells. Elife. 2017 Jun 06; 6. PMID: 28585919.
        View in: PubMed
      3. Phan AT, Goldrath AW, Glass C. Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity. Immunity. 2017 May 16; 46(5):714-729. PMID: 28514673.
        View in: PubMed
      4. Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass C, Nizet V, Varki A. Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State. J Immunol. 2017 Mar 15; 198(6):2366-2373. PMID: 28148732.
        View in: PubMed
      5. Oishi Y, Spann NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen MU, Carlin AF, Lam MT, Manabe I, Shimano H, Saghatelian A, Glass C. SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab. 2016 Dec 21. PMID: 28041958.
        View in: PubMed
      6. Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton BA, Mikulski Z, Jain MK, Glass C, Hedrick CC. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C(low) Monocytes while Preserving Macrophage Gene Function. Immunity. 2016 Oct 31. PMID: 27814941.
        View in: PubMed
      7. Eichenfield DZ, Troutman TD, Link VM, Lam MT, Cho H, Gosselin D, Spann NJ, Lesch HP, Tao J, Muto J, Gallo RL, Evans RM, Glass C. Tissue damage drives co-localization of NF-?B, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. Elife. 2016; 5. PMID: 27462873.
        View in: PubMed
      8. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass C, Dowdy SF, Desai A, Shiau AK, Oegema K. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 Jul 18; 214(2):155-66. PMID: 27432897.
        View in: PubMed
      9. Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass C. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 2016; 5. PMID: 27376549.
        View in: PubMed
      10. Glass C, Natoli G. Molecular control of activation and priming in macrophages. Nat Immunol. 2015 Dec 17; 17(1):26-33. PMID: 26681459.
        View in: PubMed
      11. Link VM, Gosselin D, Glass C. Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers. Cold Spring Harb Symp Quant Biol. 2015; 80:213-21. PMID: 26582787.
        View in: PubMed
      12. Duttke SH, Lacadie SA, Ibrahim MM, Glass C, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. Perspectives on Unidirectional versus Divergent Transcription. Mol Cell. 2015 Nov 5; 60(3):348-9. PMID: 26545075.
        View in: PubMed
      13. Romanoski CE, Link VM, Heinz S, Glass C. Exploiting genomics and natural genetic variation to decode macrophage enhancers. Trends Immunol. 2015 Sep; 36(9):507-18. PMID: 26298065.
        View in: PubMed
      14. Glass C, Witztum JL. Daniel Steinberg, 1922-2015. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9791-2. PMID: 26209653.
        View in: PubMed
      15. Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass C, Zambon AC, Chen J, Sun Y, Evans SM. Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest. 2015 Aug 3; 125(8):3256-68. PMID: 26193633.
        View in: PubMed
      16. Schwarz F, Pearce OM, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass C, Hazen SL, Varki N, Varki A, Gagneux P. Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 2015; 4. PMID: 25846707.
        View in: PubMed
      17. Glass C. Genetic and genomic approaches to understanding macrophage identity and function. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):755-62. PMID: 25745059.
        View in: PubMed
      18. Romanoski CE, Glass C, Stunnenberg HG, Wilson L, Almouzni G. Epigenomics: Roadmap for regulation. Nature. 2015 Feb 19; 518(7539):314-6. PMID: 25693562.
        View in: PubMed
      19. Heinz S, Romanoski CE, Benner C, Glass C. The selection and function of cell type-specific enhancers. Nat Rev Mol Cell Biol. 2015 Mar; 16(3):144-54. PMID: 25650801.
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      20. Duttke SH, Lacadie SA, Ibrahim MM, Glass C, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. Human promoters are intrinsically directional. Mol Cell. 2015 Feb 19; 57(4):674-84. PMID: 25639469.
        View in: PubMed
      21. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass C, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-36. PMID: 25598080.
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      22. Davis-Turak JC, Allison K, Shokhirev MN, Ponomarenko P, Tsimring LS, Glass C, Johnson TL, Hoffmann A. Considering the kinetics of mRNA synthesis in the analysis of the genome and epigenome reveals determinants of co-transcriptional splicing. Nucleic Acids Res. 2015 Jan 30; 43(2):699-707. PMID: 25541195.
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      23. Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass C. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell. 2014 Dec 4; 159(6):1327-40. PMID: 25480297.
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      24. Gordts PL, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass C, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling. Cell Metab. 2014 Nov 4; 20(5):813-26. PMID: 25440058.
        View in: PubMed
      25. Gosselin D, Glass C. Epigenomics of macrophages. Immunol Rev. 2014 Nov; 262(1):96-112. PMID: 25319330.
        View in: PubMed
      26. Lam MT, Li W, Rosenfeld MG, Glass C. Enhancer RNAs and regulated transcriptional programs. Trends Biochem Sci. 2014 Apr; 39(4):170-82. PMID: 24674738.
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      27. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass C. Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. PMID: 24584051.
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      28. Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass C, Dennis EA, Subramaniam S. Modeling of Eicosanoid Fluxes Reveals Functional Coupling between Cyclooxygenases and Terminal Synthases. Biophys J. 2014 Feb 18; 106(4):966-75. PMID: 24559999.
        View in: PubMed
      29. Zhang DX, Glass C. Towards an understanding of cell-specific functions of signal-dependent transcription factors. J Mol Endocrinol. 2013; 51(3):T37-50. PMID: 24130129.
        View in: PubMed
      30. Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass C, Olefsky JM. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26; 155(1):200-14. PMID: 24074869.
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      31. Spann NJ, Glass C. Sterols and oxysterols in immune cell function. Nat Immunol. 2013 Sep; 14(9):893-900. PMID: 23959186.
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      32. Dinasarapu AR, Gupta S, Ram Maurya M, Fahy E, Min J, Sud M, Gersten MJ, Glass C, Subramaniam S. A combined omics study on activated macrophages--enhanced role of STATs in apoptosis, immunity and lipid metabolism. Bioinformatics. 2013 Nov 1; 29(21):2735-43. PMID: 23981351.
        View in: PubMed
      33. McCarthy C, Lieggi NT, Barry D, Mooney D, de Gaetano M, James WG, McClelland S, Barry MC, Escoubet-Lozach L, Li AC, Glass C, Fitzgerald DJ, Belton O. Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid. EMBO Mol Med. 2013 Sep; 5(9):1443-57. PMID: 23964012.
        View in: PubMed
      34. Kaikkonen MU, Spann NJ, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass C. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol Cell. 2013 Aug 8; 51(3):310-25. PMID: 23932714.
        View in: PubMed
      35. Stender JD, Glass C. Epigenomic control of the innate immune response. Curr Opin Pharmacol. 2013 Aug; 13(4):582-7. PMID: 23816801.
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      36. Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass C, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res. 2013 Sep; 54(9):2525-42. PMID: 23776196.
        View in: PubMed
      37. Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, Merkurjev D, Zhang J, Ohgi K, Song X, Oh S, Kim HS, Glass C, Rosenfeld MG. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature. 2013 Jun 27; 498(7455):516-20. PMID: 23728302.
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      38. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass C. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature. 2013 Jun 27; 498(7455):511-5. PMID: 23728303.
        View in: PubMed
      39. Mansson R, Welinder E, Åhsberg J, Lin YC, Benner C, Glass C, Lucas JS, Sigvardsson M, Murre C. Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21028-33. PMID: 23213261.
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      40. Lin YC, Benner C, Mansson R, Heinz S, Miyazaki K, Miyazaki M, Chandra V, Bossen C, Glass C, Murre C. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol. 2012 Dec; 13(12):1196-204. PMID: 23064439.
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      41. Hu Q, Tanasa B, Trabucchi M, Li W, Zhang J, Ohgi KA, Rose DW, Glass C, Rosenfeld MG. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat Struct Mol Biol. 2012 Nov; 19(11):1168-75. PMID: 23064648.
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      42. Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. The transcriptional specificity of NF-?B dimers is coded within the ?B DNA response elements. Cell Rep. 2012 Oct 25; 2(4):824-39. PMID: 23063365.
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      43. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass C. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28; 151(1):138-52. PMID: 23021221.
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      44. Saijo K, Crotti A, Glass C. Regulation of microglia activation and deactivation by nuclear receptors. Glia. 2013 Jan; 61(1):104-11. PMID: 22987512.
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      45. Stender JD, Pascual G, Liu W, Kaikkonen MU, Do K, Spann NJ, Boutros M, Perrimon N, Rosenfeld MG, Glass C. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell. 2012 Oct 12; 48(1):28-38. PMID: 22921934.
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      46. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass C, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629.
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      47. Glass C, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012 May 2; 15(5):635-45. PMID: 22560216.
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      48. Cardamone MD, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass C, Rosenfeld MG, Perissi V. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13; 46(1):91-104. PMID: 22424771.
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      49. Heinz S, Glass C. Roles of lineage-determining transcription factors in establishing open chromatin: lessons from high-throughput studies. Curr Top Microbiol Immunol. 2012; 356:1-15. PMID: 21744305.
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      50. Borsting E, Cheng VP, Glass C, Vallon V, Cunard R. Peroxisome proliferator-activated receptor-? agonists repress epithelial sodium channel expression in the kidney. Am J Physiol Renal Physiol. 2012 Mar 1; 302(5):F540-51. PMID: 22169011.
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      51. Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass C. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec; 7(12):e1002401. PMID: 22174696.
        View in: PubMed
      52. Garmire LX, Garmire DG, Huang W, Yao J, Glass C, Subramaniam S. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. PLoS One. 2011; 6(9):e24051. PMID: 21980340.
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      53. Mercer EM, Lin YC, Benner C, Jhunjhunwala S, Dutkowski J, Flores M, Sigvardsson M, Ideker T, Glass C, Murre C. Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity. 2011 Sep 23; 35(3):413-25. PMID: 21903424.
        View in: PubMed
      54. Norris PC, Reichart D, Dumlao DS, Glass C, Dennis EA. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. J Leukoc Biol. 2011 Sep; 90(3):563-74. PMID: 21653236.
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      55. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass C, Brenner DA, Kisseleva T. Migration of fibrocytes in fibrogenic liver injury. Am J Pathol. 2011 Jul; 179(1):189-98. PMID: 21703401.
        View in: PubMed
      56. Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass C. An ADIOL-ERß-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell. 2011 May 13; 145(4):584-95. PMID: 21565615.
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      57. Kisseleva T, von Köckritz-Blickwede M, Reichart D, McGillvray SM, Wingender G, Kronenberg M, Glass C, Nizet V, Brenner DA. Fibrocyte-like cells recruited to the spleen support innate and adaptive immune responses to acute injury or infection. J Mol Med (Berl). 2011 Oct; 89(10):997-1013. PMID: 21499735.
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      58. Gupta S, Maurya MR, Merrill AH, Glass C, Subramaniam S. Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. BMC Syst Biol. 2011; 5:26. PMID: 21303545.
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      59. Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass C, Evans RM, Witztum JL. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45. PMID: 21273443.
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      60. Wang X, Song X, Glass C, Rosenfeld MG. The long arm of long noncoding RNAs: roles as sensors regulating gene transcriptional programs. Cold Spring Harb Perspect Biol. 2011 Jan; 3(1):a003756. PMID: 20573714.
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      61. Sullivan AL, Benner C, Heinz S, Huang W, Xie L, Miano JM, Glass C. Serum response factor utilizes distinct promoter- and enhancer-based mechanisms to regulate cytoskeletal gene expression in macrophages. Mol Cell Biol. 2011 Feb; 31(4):861-75. PMID: 21135125.
        View in: PubMed
      62. Chow OA, von Köckritz-Blickwede M, Bright AT, Hensler ME, Zinkernagel AS, Cogen AL, Gallo RL, Monestier M, Wang Y, Glass C, Nizet V. Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe. 2010 Nov 18; 8(5):445-54. PMID: 21075355.
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      63. Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass C, Olefsky JM. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010 Dec 15; 29(24):4223-36. PMID: 21045807.
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      64. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass C, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. A mouse macrophage lipidome. J Biol Chem. 2010 Dec 17; 285(51):39976-85. PMID: 20923771.
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      65. Shibata N, Glass C. Macrophages, oxysterols and atherosclerosis. Circ J. 2010 Oct; 74(10):2045-51. PMID: 20838002.
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      66. Huang W, Glass C. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1542-9. PMID: 20631355.
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      67. Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass C, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12. PMID: 20622854.
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      68. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass C, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. PMID: 20543837.
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      69. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass C. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28; 38(4):576-89. PMID: 20513432.
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      70. Kadandale P, Stender JD, Glass C, Kiger AA. Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10502-7. PMID: 20498061.
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      71. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass C, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 9; 107(1):56-65. PMID: 20489162.
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      72. Glass C, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010 Mar 19; 140(6):918-34. PMID: 20303880.
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      73. Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass C. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nat Med. 2010 Mar; 16(3):313-8. PMID: 20154695.
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      74. Perissi V, Jepsen K, Glass C, Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet. 2010 Feb; 11(2):109-23. PMID: 20084085.
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      75. Olefsky JM, Glass C. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010; 72:219-46. PMID: 20148674.
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      76. Saijo K, Crotti A, Glass C. Nuclear receptors, inflammation, and neurodegenerative diseases. Adv Immunol. 2010; 106:21-59. PMID: 20728023.
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      77. Garmire LX, Shen Z, Briggs S, Yeo G, Subramaniam S, Glass C. Regulatory network of microRNAs in RAW 264.7 macrophage cells. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:6198-201. PMID: 21097158.
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      78. Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass C, Rosenfeld MG. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell. 2009 Dec 11; 139(6):1069-83. PMID: 19962179.
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      79. Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass C. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. PMID: 19595715.
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      80. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH, Glass C. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 2009 Apr 3; 137(1):47-59. PMID: 19345186.
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      81. Ghisletti S, Huang W, Jepsen K, Benner C, Hardiman G, Rosenfeld MG, Glass C. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009 Mar 15; 23(6):681-93. PMID: 19299558.
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      82. Cook PJ, Ju BG, Telese F, Wang X, Glass C, Rosenfeld MG. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009 Apr 2; 458(7238):591-6. PMID: 19234442.
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      83. Shibata N, Glass C. Regulation of macrophage function in inflammation and atherosclerosis. J Lipid Res. 2009 Apr; 50 Suppl:S277-81. PMID: 18987388.
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      84. Steinberg D, Glass C, Witztum JL. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 2008 Aug 5; 118(6):672-7. PMID: 18678783.
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      85. Nunez E, Kwon YS, Hutt KR, Hu Q, Cardamone MD, Ohgi KA, Garcia-Bassets I, Rose DW, Glass C, Rosenfeld MG, Fu XD. Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell. 2008 Jul 11; 134(1):189. PMID: 18630350.
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      86. Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass C, Rosenfeld MG. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell. 2008 Mar 28; 29(6):755-66. PMID: 18374649.
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      87. Nunez E, Kwon YS, Hutt KR, Hu Q, Cardamone MD, Ohgi KA, Garcia-Bassets I, Rose DW, Glass C, Rosenfeld MG, Fu XD. Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell. 2008 Mar 21; 132(6):996-1010. PMID: 18358812.
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      88. Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass C, Rosenfeld MG. Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell. 2008 Jan 18; 29(1):69-80. PMID: 18206970.
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      89. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass C, Hermanson O, Rosenfeld MG. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature. 2007 Nov 15; 450(7168):415-9. PMID: 17928865.
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      90. Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass C, Neels JG, Olefsky JM. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem. 2007 Nov 30; 282(48):35279-92. PMID: 17916553.
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      91. Zhu P, Zhou W, Wang J, Puc J, Ohgi KA, Erdjument-Bromage H, Tempst P, Glass C, Rosenfeld MG. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell. 2007 Aug 17; 27(4):609-21. PMID: 17707232.
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      92. Lunyak VV, Prefontaine GG, Núñez E, Cramer T, Ju BG, Ohgi KA, Hutt K, Roy R, García-Díaz A, Zhu X, Yung Y, Montoliu L, Glass C, Rosenfeld MG. Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science. 2007 Jul 13; 317(5835):248-51. PMID: 17626886.
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      93. Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass C, Ricote M. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest. 2007 Jun; 117(6):1658-69. PMID: 17525798.
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      94. Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass C. Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS. Cell Cycle. 2007 Jul 1; 6(13):1594-604. PMID: 17525531.
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      95. Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass C, Fu XD, Rosenfeld MG. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19; 446(7138):882-7. PMID: 17392792.
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      96. Kwon YS, Garcia-Bassets I, Hutt KR, Cheng CS, Jin M, Liu D, Benner C, Wang D, Ye Z, Bibikova M, Fan JB, Duan L, Glass C, Rosenfeld MG, Fu XD. Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4852-7. PMID: 17360330.
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      97. Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass C, Fu XD, Rosenfeld MG. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 2007 Feb 9; 128(3):505-18. PMID: 17289570.
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      98. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass C. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell. 2007 Jan 12; 25(1):57-70. PMID: 17218271.
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      99. Maurya MR, Benner C, Pradervand S, Glass C, Subramaniam S. Systems biology of macrophages. Adv Exp Med Biol. 2007; 598:62-79. PMID: 17892205.
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      100. Pascual G, Sullivan AL, Ogawa S, Gamliel A, Perissi V, Rosenfeld MG, Glass C. Anti-inflammatory and antidiabetic roles of PPARgamma. Novartis Found Symp. 2007; 286:183-96; discussion 196-203. PMID: 18269183.
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      101. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass C, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev. 2006 Dec; 58(4):726-41. PMID: 17132851.
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      102. Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass C, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Res. 2007 Jan; 35(Database issue):D527-32. PMID: 17098933.
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      103. Pascual G, Glass C. Nuclear receptors versus inflammation: mechanisms of transrepression. Trends Endocrinol Metab. 2006 Oct; 17(8):321-7. PMID: 16942889.
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      104. Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass C. Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells. J Leukoc Biol. 2006 Oct; 80(4):850-61. PMID: 16888087.
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      105. Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass C, Rosenfeld MG. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science. 2006 Jun 23; 312(5781):1798-802. PMID: 16794079.
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      106. Toyo-oka K, Bowen TJ, Hirotsune S, Li Z, Jain S, Ota S, Escoubet-Lozach L, Lozach LE, Garcia-Bassets I, Bassett IG, Lozach J, Rosenfeld MG, Glass C, Eisenman R, Ren B, Hurlin P, Wynshaw-Boris A. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res. 2006 Jun 1; 66(11):5565-73. PMID: 16740691.
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      107. Rosenfeld MG, Lunyak VV, Glass C. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 2006 Jun 1; 20(11):1405-28. PMID: 16751179.
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      108. Glass C. Going nuclear in metabolic and cardiovascular disease. J Clin Invest. 2006 Mar; 116(3):556-60. PMID: 16511587.
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      109. Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass C, Rosenfeld MG, Rose DW. Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10; 124(3):615-29. PMID: 16469706.
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      110. Glass C, Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol. 2006 Jan; 6(1):44-55. PMID: 16493426.
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      111. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass C. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005 Sep 9; 122(5):707-21. PMID: 16143103.
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      112. Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass C. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature. 2005 Sep 29; 437(7059):759-63. PMID: 16127449.
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      113. Bradshaw G, Gutierrez A, Miyake JH, Davis KR, Li AC, Glass C, Curtiss LK, Davis RA. Facilitated replacement of Kupffer cells expressing a paraoxonase-1 transgene is essential for ameliorating atherosclerosis in mice. Proc Natl Acad Sci U S A. 2005 Aug 2; 102(31):11029-34. PMID: 16043712.
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      114. Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass C, Rosenfeld MG, Myers RM, Ren B. Direct isolation and identification of promoters in the human genome. Genome Res. 2005 Jun; 15(6):830-9. PMID: 15899964.
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      115. Fahy E, Subramaniam S, Brown HA, Glass C, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. PMID: 15722563.
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      116. Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass C, Rosenfeld MG. Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway. Cell. 2004 Dec 17; 119(6):815-29. PMID: 15607978.
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      117. Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass C. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8. PMID: 15601766.
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      118. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass C. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest. 2004 Dec; 114(11):1564-76. PMID: 15578089.
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      119. Ogawa S, Glass C. Factor XIIIA (cross)links AT1 receptors to atherosclerosis. Cell. 2004 Oct 29; 119(3):313-4. PMID: 15507203.
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      120. Li AC, Glass C. PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J Lipid Res. 2004 Dec; 45(12):2161-73. PMID: 15489539.
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      121. Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V, Sasik R, Rose DW, Johnson RS, Rosenfeld MG, Glass C. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A. 2004 Oct 5; 101(40):14461-6. PMID: 15452344.
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      122. Cunard R, Eto Y, Muljadi JT, Glass C, Kelly CJ, Ricote M. Repression of IFN-gamma expression by peroxisome proliferator-activated receptor gamma. J Immunol. 2004 Jun 15; 172(12):7530-6. PMID: 15187132.
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      123. Glass C, McDonnell DP. The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. Mol Cell. 2004 Feb 27; 13(4):459-67. PMID: 14992717.
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      124. Perissi V, Aggarwal A, Glass C, Rose DW, Rosenfeld MG. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell. 2004 Feb 20; 116(4):511-26. PMID: 14980219.
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      125. Sawka-Verhelle D, Escoubet-Lozach L, Fong AL, Hester KD, Herzig S, Lebrun P, Glass C. PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation. J Biol Chem. 2004 Apr 23; 279(17):17772-84. PMID: 14754893.
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      126. Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass C, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20; 426(6964):247-54. PMID: 14628042.
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      127. Ricote M, Valledor AF, Glass C. Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):230-9. PMID: 14592855.
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      128. Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass C. Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Mol Cell Biol. 2003 Aug; 23(16):5780-9. PMID: 12897148.
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      129. Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass C. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6712-7. PMID: 12740443.
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      130. Baek SH, Kioussi C, Briata P, Wang D, Nguyen HD, Ohgi KA, Glass C, Wynshaw-Boris A, Rose DW, Rosenfeld MG. Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3245-50. PMID: 12629224.
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      131. Söderström M, Wigren J, Surapureddi S, Glass C, Hammarström S. Novel prostaglandin D(2)-derived activators of peroxisome proliferator-activated receptor-gamma are formed in macrophage cell cultures. Biochim Biophys Acta. 2003 Feb 20; 1631(1):35-41. PMID: 12573447.
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      132. Cunard R, DiCampli D, Archer DC, Stevenson JL, Ricote M, Glass C, Kelly CJ. WY14,643, a PPAR alpha ligand, has profound effects on immune responses in vivo. J Immunol. 2002 Dec 15; 169(12):6806-12. PMID: 12471112.
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      133. Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass C, Wynshaw-Boris A, Rosenfeld MG. Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development. Cell. 2002 Nov 27; 111(5):673-85. PMID: 12464179.
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      134. Li AC, Glass C. The macrophage foam cell as a target for therapeutic intervention. Nat Med. 2002 Nov; 8(11):1235-42. PMID: 12411950.
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      135. Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science. 2002 Nov 29; 298(5599):1747-52. PMID: 12399542.
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      136. Escoubet-Lozach L, Glass C, Wasserman SI. The role of transcription factors in allergic inflammation. J Allergy Clin Immunol. 2002 Oct; 110(4):553-64. PMID: 12373260.
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      137. Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass C. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem. 2002 Nov 8; 277(45):42821-9. PMID: 12215441.
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      138. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass C, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002 Jul 12; 110(1):55-67. PMID: 12150997.
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      139. Klappacher GW, Glass C. Roles of peroxisome proliferator-activated receptor gamma in lipid homeostasis and inflammatory responses of macrophages. Curr Opin Lipidol. 2002 Jun; 13(3):305-12. PMID: 12045401.
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      140. Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass C. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002 Apr 19; 109(2):169-80. PMID: 12007404.
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      141. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass C, Brewer HB, Gonzalez FJ. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol. 2002 Apr; 22(8):2607-19. PMID: 11909955.
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      142. Napoli C, de Nigris F, Welch JS, Calara FB, Stuart RO, Glass C, Palinski W. Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray. Circulation. 2002 Mar 19; 105(11):1360-7. PMID: 11901049.
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      143. Cunard R, Ricote M, DiCampli D, Archer DC, Kahn DA, Glass C, Kelly CJ. Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors. J Immunol. 2002 Mar 15; 168(6):2795-802. PMID: 11884448.
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      144. Hermanson O, Glass C, Rosenfeld MG. Nuclear receptor coregulators: multiple modes of modification. Trends Endocrinol Metab. 2002 Mar; 13(2):55-60. PMID: 11854019.
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      145. Glass C. Potential roles of the peroxisome proliferator-activated receptor-gamma in macrophage biology and atherosclerosis. J Endocrinol. 2001 Jun; 169(3):461-4. PMID: 11375116.
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      146. Glass C, Witztum JL. Atherosclerosis. the road ahead. Cell. 2001 Feb 23; 104(4):503-16. PMID: 11239408.
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