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    John Chang

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0063
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Stanford UniversityBS1995Biological Sciences Medicine
      NIH, BethesdaResearch Scholar1999HHMI-NIH
      Temple UniversityMD2001Medicine
      University of PennsylvaniaInternship / Residency2004Internal Medicine
      University of PennsylvaniaFellowship2007Gastroenterology
      University of PennsylvaniaPostdoctoral2009Immunology

      Collapse Research 
      Collapse Research Activities and Funding
      Role of proteasome activity in adaptive immunity
      NIH/NIAID R01AI129973Dec 1, 2017 - Nov 30, 2022
      Role: Principal Investigator
      Interrogating adaptive immunity to microbial infection
      VA I01BX003424Oct 1, 2016 - Sep 30, 2020
      Role: Principal Investigator
      Using single-cell RNA-seq to interrogate host immunity to pathogens
      NIH/NIAID R01AI123202Sep 23, 2016 - Aug 31, 2021
      Role: Principal Investigator
      Role of atypical Protein Kinase C in Inflammatory Bowel Disease
      NIH/NIDDK R01DK093507Apr 1, 2012 - Mar 31, 2017
      Role: Principal Investigator
      Modulating the Proteasome in Inflammatory Bowel Disease
      NIH/NIDDK R03DK093593Mar 2, 2012 - Feb 28, 2014
      Role: Principal Investigator
      Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
      NIH/NIAID R01AI095277Dec 1, 2011 - Nov 30, 2016
      Role: Principal Investigator
      Understanding the Basis for Cellular Diversity During Adaptive Immunity
      NIH DP2OD008469Sep 30, 2011 - Jun 30, 2016
      Role: Principal Investigator
      Asymmetric T cell division initiating adaptive immunity and colitis
      NIH/NIDDK K08DK080949Jul 1, 2008 - Jun 30, 2013
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR, Goldrath AW, Overkleeft HS, Ovaa H, Chang J. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017 Aug 28. PMID: 28846070.
        View in: PubMed
      2. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang J, Pipkin ME, Wang W, Goldrath AW. Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 May 18; 18(6):705. PMID: 28518161.
        View in: PubMed
      3. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang J. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 Jun 15; 198(12):4639-4651. PMID: 28515282.
        View in: PubMed
      4. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang J, Pipkin ME, Wang W, Goldrath AW. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 May; 18(5):573-582. PMID: 28288100.
        View in: PubMed
      5. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang J, Yeo GW. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 Apr; 18(4):422-432. PMID: 28218746.
        View in: PubMed
      6. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang J, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 Sep; 66(9):1584-1596. PMID: 27325418.
        View in: PubMed
      7. Dulai PS, Singh S, Jiang X, Peerani F, Narula N, Chaudrey K, Whitehead D, Hudesman D, Lukin D, Swaminath A, Shmidt E, Wang S, Boland BS, Chang J, Kane S, Siegel CA, Loftus EV, Sandborn WJ, Sands BE, Colombel JF. The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium. Am J Gastroenterol. 2016 Aug; 111(8):1147-55. PMID: 27296941.
        View in: PubMed
      8. Boland BS, Bagi P, Valasek MA, Chang J, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 May; 111(5):746-8. PMID: 27151126.
        View in: PubMed
      9. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang J. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. 2016 Apr 19; 7(16):21527-41. PMID: 26930717; PMCID: PMC5008303.
      10. Ngoi SM, Lopez JM, Chang J. The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. J Immunol. 2016 May 15; 196(10):4237-45. PMID: 27029586; PMCID: PMC4868634 [Available on 05/15/17].
      11. Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang J. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016 Jan 14; 6:19182. PMID: 26765121; PMCID: PMC4725917.
      12. Ablack JN, Metz PJ, Chang J, Cantor JM, Ginsberg MH. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. PMID: 26493331; PMCID: PMC4712820 [Available on 12/01/16].
      13. Arsenio J, Metz PJ, Chang J. Asymmetric Cell Division in T Lymphocyte Fate Diversification. Trends Immunol. 2015 Nov; 36(11):670-683. PMID: 26474675; PMCID: PMC4640954 [Available on 11/01/16].
      14. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang J, Gonzalez DJ, Nizet V. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015 Oct 13; 6:8369. PMID: 26458291; PMCID: PMC4610010.
      15. Arsenio J, Kakaradov B, Metz PJ, Yeo GW, Chang J. Reply to: "CD8(+) T cell diversification by asymmetric cell division". Nat Immunol. 2015 Sep; 16(9):893-4. PMID: 26287585; PMCID: PMC4758127.
      16. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang J, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
      17. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang J. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015 Mar 15; 194(6):2551-60. PMID: 25667416; PMCID: PMC4355235.
      18. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang J. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. PMID: 25545378; PMCID: PMC4404151.
      19. Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang J. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase C? and protein kinase C?/?. J Immunol. 2015 Mar 01; 194(5):2249-59. PMID: 25617472; PMCID: PMC4340726.
      20. Chang J, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1104-15. PMID: 25396352; PMCID: PMC4386685.
      21. Barrera DJ, Rosenberg JN, Chiu JG, Chang YN, Debatis M, Ngoi SM, Chang J, Shoemaker CB, Oyler GA, Mayfield SP. Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin. Plant Biotechnol J. 2015 Jan; 13(1):117-24. PMID: 25229405; PMCID: PMC4620920.
      22. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang J. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. PMID: 25041724; PMCID: PMC4143528.
      23. Boland BS, Sandborn WJ, Chang J. Update on Janus kinase antagonists in inflammatory bowel disease. Gastroenterol Clin North Am. 2014 Sep; 43(3):603-17. PMID: 25110261; PMCID: PMC4129380.
      24. Chang J, Sandborn WJ, Ernst PB. Studies in human intestinal tissues: is it time to reemphasize research in human immunology? Gastroenterology. 2014 Jul; 147(1):26-30. PMID: 24877864.
        View in: PubMed
      25. Jung HR, Song KH, Chang J, Doh J. Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. PLoS One. 2014; 9(3):e91926. PMID: 24632942; PMCID: PMC3954838.
      26. Arsenio J, Kakaradov B, Metz PJ, Kim SH, Yeo GW, Chang J. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat Immunol. 2014 Apr; 15(4):365-372. PMID: 24584088; PMCID: PMC3968536.
      27. Kwong WT, Chang J. Endoscopic retrieval of ingested nails using a refrigerator magnet. Clin Gastroenterol Hepatol. 2013 Sep; 11(9):A24. PMID: 23333705.
        View in: PubMed
      28. Pola S, Patel D, Ramamoorthy S, McLemore E, Fahmy M, Rivera-Nieves J, Chang J, Evans E, Docherty M, Talamini M, Sandborn WJ. Strategies for the care of adults hospitalized for active ulcerative colitis. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1315-1325.e4. PMID: 22835577; PMCID: PMC4226798.
      29. Chang J. Polarity and lymphocyte fate determination. Curr Opin Cell Biol. 2012 Aug; 24(4):526-33. PMID: 22658837; PMCID: PMC3425726.
      30. Ciocca ML, Barnett BE, Burkhardt JK, Chang J, Reiner SL. Cutting edge: Asymmetric memory T cell division in response to rechallenge. J Immunol. 2012 May 01; 188(9):4145-8. PMID: 22467651; PMCID: PMC3331961.
      31. Cantor J, Slepak M, Ege N, Chang J, Ginsberg MH. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318; PMCID: PMC3131465.
      32. Chang J, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22; 34(4):492-504. PMID: 21497118; PMCID: PMC3088519.
      33. Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang J, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM. Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol. 2010 Jul 01; 185(1):367-75. PMID: 20530266; PMCID: PMC3739982.
      34. Kambayashi T, Allenspach EJ, Chang J, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA. Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol. 2009 Apr 15; 182(8):4686-95. PMID: 19342644; PMCID: PMC2922395.
      35. Chang J, Reiner SL. Asymmetric division and stem cell renewal without a permanent niche: lessons from lymphocytes. Cold Spring Harb Symp Quant Biol. 2008; 73:73-9. PMID: 19022740.
        View in: PubMed
      36. Chang J, Reiner SL. Specifying helper T cell fates during immunity. J Pediatr Gastroenterol Nutr. 2008 Apr; 46 Suppl 1:E19-20. PMID: 18354322.
        View in: PubMed
      37. Chang J, Reiner SL. Protection one cell thick. Immunity. 2007 Dec; 27(6):832-4. PMID: 18093536.
        View in: PubMed
      38. Chang J, Ganz DA. Quality indicators for falls and mobility problems in vulnerable elders. J Am Geriatr Soc. 2007 Oct; 55 Suppl 2:S327-34. PMID: 17910554.
        View in: PubMed
      39. Chang J, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007 Mar 23; 315(5819):1687-91. PMID: 17332376.
        View in: PubMed
      40. Chang J, Lichtenstein GR. Drug insight: antagonists of tumor-necrosis factor-alpha in the treatment of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Apr; 3(4):220-8. PMID: 16582964.
        View in: PubMed
      41. Chang J, Katzka DA. Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004 Jul 26; 164(14):1482-8. PMID: 15277277.
        View in: PubMed
      42. Chang J, Morton SC, Rubenstein LZ, Mojica WA, Maglione M, Suttorp MJ, Roth EA, Shekelle PG. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ. 2004 Mar 20; 328(7441):680. PMID: 15031239; PMCID: PMC381224.
      43. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang J, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000 Jul 15; 165(2):915-24. PMID: 10878366.
        View in: PubMed
      44. Segal BM, Chang J, Shevach EM. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J Immunol. 2000 Jun 01; 164(11):5683-8. PMID: 10820244.
        View in: PubMed
      45. Chang J, Segal BM, Nakanishi K, Okamura H, Shevach EM. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol. 2000 Apr; 30(4):1113-9. PMID: 10760800.
        View in: PubMed
      46. Chang J, Segal BM, Shevach EM. Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J Immunol. 2000 Jan 01; 164(1):100-6. PMID: 10604999.
        View in: PubMed
      47. Chang J, Shevach EM, Segal BM. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med. 1999 Mar 15; 189(6):969-78. PMID: 10075980; PMCID: PMC2193042.
      48. Shevach EM, Chang J, Segal BM. The critical role of IL-12 and the IL-12R beta 2 subunit in the generation of pathogenic autoreactive Th1 cells. Springer Semin Immunopathol. 1999; 21(3):249-62. PMID: 10666772.
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