John Chang

TitleAssociate Professor In Residence
InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0063
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityBS1995Biological Sciences Medicine
    NIH, BethesdaResearch Scholar1999HHMI-NIH
    Temple UniversityMD2001Medicine
    University of PennsylvaniaInternship / Residency2004Internal Medicine
    University of PennsylvaniaFellowship2007Gastroenterology
    University of PennsylvaniaPostdoctoral2009Immunology

    Collapse Research 
    Collapse Research Activities and Funding
    Role of proteasome activity in adaptive immunity
    NIH/NIAID R01AI129973Dec 1, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Interrogating adaptive immunity to microbial infection
    VA I01BX003424Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Using single-cell RNA-seq to interrogate host immunity to pathogens
    NIH/NIAID R01AI123202Sep 23, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Role of atypical Protein Kinase C in Inflammatory Bowel Disease
    NIH/NIDDK R01DK093507Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Modulating the Proteasome in Inflammatory Bowel Disease
    NIH/NIDDK R03DK093593Mar 2, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Regulation and Function of Polarity and Asymmetric Cell Division in Immunity
    NIH/NIAID R01AI095277Dec 1, 2011 - Nov 30, 2016
    Role: Principal Investigator
    Understanding the Basis for Cellular Diversity During Adaptive Immunity
    NIH DP2OD008469Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Asymmetric T cell division initiating adaptive immunity and colitis
    NIH/NIDDK K08DK080949Jul 1, 2008 - Jun 30, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 Sep 12. PMID: 30209212.
      View in: PubMed
    2. Dulai PS, Boland BS, Singh S, Chaudrey K, Koliani-Pace JL, Kochhar G, Parikh MP, Shmidt E, Hartke J, Chilukuri P, Meserve J, Whitehead D, Hirten R, Winters AC, Katta LG, Peerani F, Narula N, Sultan K, Swaminath A, Bohm M, Lukin D, Hudesman D, Chang JT, Rivera-Nieves J, Jairath V, Zou GY, Feagan BG, Shen B, Siegel CA, Loftus EV, Kane S, Sands BE, Colombel JF, Sandborn WJ, Lasch K, Cao C. Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients with Crohn's Disease. Gastroenterology. 2018 May 29. PMID: 29857091.
      View in: PubMed
    3. Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT. USP11 Enhances TGFß-induced Epithelial-mesenchymal Plasticity and Human Breast Cancer Metastasis. Mol Cancer Res. 2018 May 03. PMID: 29724812.
      View in: PubMed
    4. Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, Ginsberg MH, Petrich BG, Chang JT. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 2018 Apr 27. PMID: 29703862.
      View in: PubMed
    5. Dulai PS, Buckey JC, Raffals LE, Swoger JM, Claus PL, O'Toole K, Ptak JA, Gleeson MW, Widjaja CE, Chang JT, Adler JM, Patel N, Skinner LA, Haren SP, Goldby-Reffner K, Thompson KD, Siegel CA. Hyperbaric oxygen therapy is well tolerated and effective for ulcerative colitis patients hospitalized for moderate-severe flares: a phase 2A pilot multi-center, randomized, double-blind, sham-controlled trial. Am J Gastroenterol. 2018 Feb 16. PMID: 29453383.
      View in: PubMed
    6. Moustafa A, Li W, Anderson EL, Wong EHM, Dulai PS, Sandborn WJ, Biggs W, Yooseph S, Jones MB, Venter JC, Nelson KE, Chang JT, Telenti A, Boland BS. Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clin Transl Gastroenterol. 2018 Jan 18; 9(1):e132. PMID: 29345635.
      View in: PubMed
    7. Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest. 2017 Oct 02; 127(10):3609-3623. PMID: 28846070.
      View in: PubMed
    8. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 05 18; 18(6):705. PMID: 28518161.
      View in: PubMed
    9. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 06 15; 198(12):4639-4651. PMID: 28515282.
      View in: PubMed
    10. Yu B, Zhang K, Milner JJ, Toma C, Chen R, Scott-Browne JP, Pereira RM, Crotty S, Chang JT, Pipkin ME, Wang W, Goldrath AW. Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Nat Immunol. 2017 05; 18(5):573-582. PMID: 28288100.
      View in: PubMed
    11. Kakaradov B, Arsenio J, Widjaja CE, He Z, Aigner S, Metz PJ, Yu B, Wehrens EJ, Lopez J, Kim SH, Zuniga EI, Goldrath AW, Chang JT, Yeo GW. Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing. Nat Immunol. 2017 04; 18(4):422-432. PMID: 28218746.
      View in: PubMed
    12. Bertin S, Aoki-Nonaka Y, Lee J, de Jong PR, Kim P, Han T, Yu T, To K, Takahashi N, Boland BS, Chang JT, Ho SB, Herdman S, Corr M, Franco A, Sharma S, Dong H, Akopian AN, Raz E. The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1. Gut. 2017 09; 66(9):1584-1596. PMID: 27325418.
      View in: PubMed
    13. Dulai PS, Singh S, Jiang X, Peerani F, Narula N, Chaudrey K, Whitehead D, Hudesman D, Lukin D, Swaminath A, Shmidt E, Wang S, Boland BS, Chang JT, Kane S, Siegel CA, Loftus EV, Sandborn WJ, Sands BE, Colombel JF. The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium. Am J Gastroenterol. 2016 Aug; 111(8):1147-55. PMID: 27296941.
      View in: PubMed
    14. Boland BS, Bagi P, Valasek MA, Chang JT, Bustamante R, Madlensky L, Sandborn WJ, Harismendy O, Gupta S. Cronkhite Canada Syndrome: Significant Response to Infliximab and a Possible Clue to Pathogenesis. Am J Gastroenterol. 2016 05; 111(5):746-8. PMID: 27151126.
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    15. Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, Chang JT. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. 2016 Apr 19; 7(16):21527-41. PMID: 26930717; PMCID: PMC5008303.
    16. Ngoi SM, Lopez JM, Chang JT. The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. J Immunol. 2016 05 15; 196(10):4237-45. PMID: 27029586; PMCID: PMC4868634 [Available on 05/15/17].
    17. Metz PJ, Lopez J, Kim SH, Akimoto K, Ohno S, Chang JT. Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep. 2016 Jan 14; 6:19182. PMID: 26765121; PMCID: PMC4725917.
    18. Ablack JN, Metz PJ, Chang JT, Cantor JM, Ginsberg MH. Ubiquitylation of CD98 limits cell proliferation and clonal expansion. J Cell Sci. 2015 Dec 01; 128(23):4273-8. PMID: 26493331; PMCID: PMC4712820 [Available on 12/01/16].
    19. Arsenio J, Metz PJ, Chang JT. Asymmetric Cell Division in T Lymphocyte Fate Diversification. Trends Immunol. 2015 Nov; 36(11):670-683. PMID: 26474675; PMCID: PMC4640954 [Available on 11/01/16].
    20. Corriden R, Hollands A, Olson J, Derieux J, Lopez J, Chang JT, Gonzalez DJ, Nizet V. Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide. Nat Commun. 2015 Oct 13; 6:8369. PMID: 26458291; PMCID: PMC4610010.
    21. Arsenio J, Kakaradov B, Metz PJ, Yeo GW, Chang JT. Reply to: "CD8(+) T cell diversification by asymmetric cell division". Nat Immunol. 2015 Sep; 16(9):893-4. PMID: 26287585; PMCID: PMC4758127.
    22. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
    23. Boland BS, Widjaja CE, Banno A, Zhang B, Kim SH, Stoven S, Peterson MR, Jones MC, Su HI, Crowe SE, Bui JD, Ho SB, Okugawa Y, Goel A, Marietta EV, Khosroheidari M, Jepsen K, Aramburu J, López-Rodríguez C, Sandborn WJ, Murray JA, Harismendy O, Chang JT. Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency. J Immunol. 2015 Mar 15; 194(6):2551-60. PMID: 25667416; PMCID: PMC4355235.
    24. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. PMID: 25545378; PMCID: PMC4404151.
    25. Metz PJ, Arsenio J, Kakaradov B, Kim SH, Remedios KA, Oakley K, Akimoto K, Ohno S, Yeo GW, Chang JT. Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase C? and protein kinase C?/?. J Immunol. 2015 Mar 01; 194(5):2249-59. PMID: 25617472; PMCID: PMC4340726.
    26. Chang JT, Wherry EJ, Goldrath AW. Molecular regulation of effector and memory T cell differentiation. Nat Immunol. 2014 Dec; 15(12):1104-15. PMID: 25396352; PMCID: PMC4386685.
    27. Barrera DJ, Rosenberg JN, Chiu JG, Chang YN, Debatis M, Ngoi SM, Chang JT, Shoemaker CB, Oyler GA, Mayfield SP. Algal chloroplast produced camelid VH H antitoxins are capable of neutralizing botulinum neurotoxin. Plant Biotechnol J. 2015 Jan; 13(1):117-24. PMID: 25229405; PMCID: PMC4620920.
    28. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. PMID: 25041724; PMCID: PMC4143528.
    29. Boland BS, Sandborn WJ, Chang JT. Update on Janus kinase antagonists in inflammatory bowel disease. Gastroenterol Clin North Am. 2014 Sep; 43(3):603-17. PMID: 25110261; PMCID: PMC4129380.
    30. Chang JT, Sandborn WJ, Ernst PB. Studies in human intestinal tissues: is it time to reemphasize research in human immunology? Gastroenterology. 2014 Jul; 147(1):26-30. PMID: 24877864.
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    31. Jung HR, Song KH, Chang JT, Doh J. Geometrically controlled asymmetric division of CD4+ T cells studied by immunological synapse arrays. PLoS One. 2014; 9(3):e91926. PMID: 24632942; PMCID: PMC3954838.
    32. Arsenio J, Kakaradov B, Metz PJ, Kim SH, Yeo GW, Chang JT. Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses. Nat Immunol. 2014 Apr; 15(4):365-372. PMID: 24584088; PMCID: PMC3968536.
    33. Kwong WT, Chang JT. Endoscopic retrieval of ingested nails using a refrigerator magnet. Clin Gastroenterol Hepatol. 2013 Sep; 11(9):A24. PMID: 23333705.
      View in: PubMed
    34. Pola S, Patel D, Ramamoorthy S, McLemore E, Fahmy M, Rivera-Nieves J, Chang JT, Evans E, Docherty M, Talamini M, Sandborn WJ. Strategies for the care of adults hospitalized for active ulcerative colitis. Clin Gastroenterol Hepatol. 2012 Dec; 10(12):1315-1325.e4. PMID: 22835577; PMCID: PMC4226798.
    35. Chang JT. Polarity and lymphocyte fate determination. Curr Opin Cell Biol. 2012 Aug; 24(4):526-33. PMID: 22658837; PMCID: PMC3425726.
    36. Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL. Cutting edge: Asymmetric memory T cell division in response to rechallenge. J Immunol. 2012 May 01; 188(9):4145-8. PMID: 22467651; PMCID: PMC3331961.
    37. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg MH. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318; PMCID: PMC3131465.
    38. Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 2011 Apr 22; 34(4):492-504. PMID: 21497118; PMCID: PMC3088519.
    39. Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM. Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol. 2010 Jul 01; 185(1):367-75. PMID: 20530266; PMCID: PMC3739982.
    40. Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA. Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. J Immunol. 2009 Apr 15; 182(8):4686-95. PMID: 19342644.
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    41. Chang JT, Reiner SL. Asymmetric division and stem cell renewal without a permanent niche: lessons from lymphocytes. Cold Spring Harb Symp Quant Biol. 2008; 73:73-9. PMID: 19022740.
      View in: PubMed
    42. Chang JT, Reiner SL. Specifying helper T cell fates during immunity. J Pediatr Gastroenterol Nutr. 2008 Apr; 46 Suppl 1:E19-20. PMID: 18354322.
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    43. Chang JT, Reiner SL. Protection one cell thick. Immunity. 2007 Dec; 27(6):832-4. PMID: 18093536.
      View in: PubMed
    44. Chang JT, Ganz DA. Quality indicators for falls and mobility problems in vulnerable elders. J Am Geriatr Soc. 2007 Oct; 55 Suppl 2:S327-34. PMID: 17910554.
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    45. Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007 Mar 23; 315(5819):1687-91. PMID: 17332376.
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    46. Chang JT, Lichtenstein GR. Drug insight: antagonists of tumor-necrosis factor-alpha in the treatment of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2006 Apr; 3(4):220-8. PMID: 16582964.
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    47. Chang JT, Katzka DA. Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med. 2004 Jul 26; 164(14):1482-8. PMID: 15277277.
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    48. Chang JT, Morton SC, Rubenstein LZ, Mojica WA, Maglione M, Suttorp MJ, Roth EA, Shekelle PG. Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials. BMJ. 2004 Mar 20; 328(7441):680. PMID: 15031239; PMCID: PMC381224.
    49. Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. J Immunol. 2000 Jul 15; 165(2):915-24. PMID: 10878366.
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    50. Segal BM, Chang JT, Shevach EM. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J Immunol. 2000 Jun 01; 164(11):5683-8. PMID: 10820244.
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    51. Chang JT, Segal BM, Nakanishi K, Okamura H, Shevach EM. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit. Eur J Immunol. 2000 Apr; 30(4):1113-9. PMID: 10760800.
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    52. Chang JT, Segal BM, Shevach EM. Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J Immunol. 2000 Jan 01; 164(1):100-6. PMID: 10604999.
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    53. Chang JT, Shevach EM, Segal BM. Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells. J Exp Med. 1999 Mar 15; 189(6):969-78. PMID: 10075980; PMCID: PMC2193042.
    54. Shevach EM, Chang JT, Segal BM. The critical role of IL-12 and the IL-12R beta 2 subunit in the generation of pathogenic autoreactive Th1 cells. Springer Semin Immunopathol. 1999; 21(3):249-62. PMID: 10666772.
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