Majid Ghassemian

Title(s)Project Scientist, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, TorontoPH.D.12/1999Signal transduction
    Institution Location Degree Completion Date Field of Study Action University of Toronto, TorontoMSc05/1995Microbiology
    Institution Location Degree Completion Date Field of Study Action University of Toronto, TorontoBSc05/1994Molecular Medical Genetics/Microbiology

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils. Sci Adv. 2023 Dec 22; 9(51):eadj1397. Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, Croker BA. PMID: 38117877; PMCID: PMC10732518.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. bioRxiv. 2023 Sep 22. Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, Ghassemian M, Yeo GW, Pogliano J, Corbett KD. PMID: 37790334; PMCID: PMC10542519.
      View in: PubMed   Mentions:
    3. Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection. bioRxiv. 2023 Sep 21. Armbruster EG, Lee J, Hutchings J, VanderWal AR, Enustun E, Adler BA, Aindow A, Deep A, Rodriguez ZK, Morgan CJ, Ghassemian M, Charles E, Cress BF, Savage DF, Doudna JA, Pogliano K, Corbett KD, Villa E, Pogliano J. PMID: 37781618; PMCID: PMC10541120.
      View in: PubMed   Mentions:
    4. Identification of the bacteriophage nucleus protein interaction network. Nat Struct Mol Biol. 2023 Nov; 30(11):1653-1662. Enustun E, Deep A, Gu Y, Nguyen KT, Chaikeeratisak V, Armbruster E, Ghassemian M, Villa E, Pogliano J, Corbett KD. PMID: 37667030; PMCID: PMC10643120.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Identification of the bacteriophage nucleus protein interaction network. bioRxiv. 2023 May 18. Enustun E, Deep A, Gu Y, Nguyen KT, Chaikeeratisak V, Armbruster E, Ghassemian M, Villa E, Pogliano J, Corbett KD. PMID: 37292858; PMCID: PMC10245766.
      View in: PubMed   Mentions:
    6. Elemental, fatty acid, and protein composition of appendicoliths. Sci Rep. 2022 11 17; 12(1):19764. Prieto JM, Wang AW, Halbach J, Cauvi DM, Day JMD, Gembicky M, Ghassemian M, Quehenberger O, Kling K, Ignacio R, DeMaio A, Bickler SW. PMID: 36396724; PMCID: PMC9671961.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol. 2022 05; 24(5):793-804. Yan W, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S, Wang SE. PMID: 35469018; PMCID: PMC9107513.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    8. Digestive Enzyme Activity and Protein Degradation in Plasma of Heart Failure Patients. Cell Mol Bioeng. 2021 Dec; 14(6):583-596. Courelli V, Ahmad A, Ghassemian M, Pruitt C, Mills PJ, Schmid-Schönbein GW. PMID: 34900012; PMCID: PMC8630255.
      View in: PubMed   Mentions: 3  
    9. A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding. J Biol Chem. 2021 Jan-Jun; 296:100493. Ear J, Abd El-Hafeez AA, Roy S, Ngo T, Rajapakse N, Choi J, Khandelwal S, Ghassemian M, McCaffrey L, Kufareva I, Sahoo D, Ghosh P. PMID: 33675748; PMCID: PMC8042451.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Cancer-secreted miRNAs regulate amino-acid-induced mTORC1 signaling and fibroblast protein synthesis. EMBO Rep. 2021 02 03; 22(2):e51239. Fong MY, Yan W, Ghassemian M, Wu X, Zhou X, Cao M, Jiang L, Wang J, Liu X, Zhang J, Wang SE. PMID: 33345445; PMCID: PMC7857427.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    11. Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes. 2021 03; 70(3):665-679. Cividini F, Scott BT, Suarez J, Casteel DE, Heinz S, Dai A, Diemer T, Suarez JA, Benner CW, Ghassemian M, Dillmann WH. PMID: 33303689; PMCID: PMC7897348.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28763-28774. Kalogriopoulos NA, Lopez-Sanchez I, Lin C, Ngo T, Midde KK, Roy S, Aznar N, Murray F, Garcia-Marcos M, Kufareva I, Ghassemian M, Ghosh P. PMID: 33139573; PMCID: PMC7682395.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. PLoS Negl Trop Dis. 2020 04; 14(4):e0008224. Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L. PMID: 32302296; PMCID: PMC7190177.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. iScience. 2020 Feb 21; 23(2):100859. Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, Ghosh P. PMID: 32058970; PMCID: PMC7005484.
      View in: PubMed   Mentions: 6  
    15. miR-486 is modulated by stretch and increases ventricular growth. JCI Insight. 2019 09 12; 4(19). Lange S, Banerjee I, Carrion K, Serrano R, Habich L, Kameny R, Lengenfelder L, Dalton N, Meili R, Börgeson E, Peterson K, Ricci M, Lincoln J, Ghassemian M, Fineman J, Del Álamo JC, Nigam V. PMID: 31513548; PMCID: PMC6795397.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia. Infect Immun. 2019 06; 87(6). Davids BJ, Liu CM, Hanson EM, Le CHY, Ang J, Hanevik K, Fischer M, Radunovic M, Langeland N, Ferella M, Svärd SG, Ghassemian M, Miyamoto Y, Eckmann L. PMID: 30962402; PMCID: PMC6529650.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    17. An endogenous peptide marker differentiates SOD1 stability and facilitates pharmacodynamic monitoring in SOD1 amyotrophic lateral sclerosis. JCI Insight. 2019 05 16; 4(10). Gertsman I, Wuu J, McAlonis-Downes M, Ghassemian M, Ling K, Rigo F, Bennett F, Benatar M, Miller TM, Da Cruz S. PMID: 31092730; PMCID: PMC6542602.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism. Commun Biol. 2019; 2:178. Blondelle J, Marrocco V, Clark M, Desmond P, Myers S, Nguyen J, Wright M, Bremner S, Pierantozzi E, Ward S, Estève E, Sorrentino V, Ghassemian M, Lange S. PMID: 31098411; PMCID: PMC6509138.
      View in: PubMed   Mentions: 10  Translation:HumansAnimalsCells
    19. Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy. JCI Insight. 2019 04 16; 5. Blondelle J, Tallapaka K, Seto JT, Ghassemian M, Clark M, Laitila JM, Bournazos A, Singer JD, Lange S. PMID: 30990797; PMCID: PMC6542616.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    20. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 02 27; 11(519). Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. PMID: 29487190; PMCID: PMC5862031.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    21. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Mol Cell. 2017 Aug 03; 67(3):484-497.e5. Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G. PMID: 28689659; PMCID: PMC6571149.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    22. Sec24 phosphorylation regulates autophagosome abundance during nutrient deprivation. Elife. 2016 11 18; 5. Davis S, Wang J, Zhu M, Stahmer K, Lakshminarayan R, Ghassemian M, Jiang Y, Miller EA, Ferro-Novick S. PMID: 27855785; PMCID: PMC5148606.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    23. Analysis of mRNA recognition by human thymidylate synthase. Biosci Rep. 2014 Dec 23; 34(6):e00168. Brunn ND, Dibrov SM, Kao MB, Ghassemian M, Hermann T. PMID: 25423174; PMCID: PMC4274661.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    24. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. PMID: 25429466; PMCID: PMC4245998.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. PMID: 25422367; PMCID: PMC6137862.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development. Nature. 2014 Sep 11; 513(7517):246-50. Engineer CB, Ghassemian M, Anderson JC, Peck SC, Hu H, Schroeder JI. PMID: 25043023; PMCID: PMC4274335.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    27. Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol. 2014 Jan 20; 204(2):247-63. Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD. PMID: 24446483; PMCID: PMC3897185.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    28. Expanding proteome coverage with orthogonal-specificity α-lytic proteases. Mol Cell Proteomics. 2014 Mar; 13(3):823-35. Meyer JG, Kim S, Maltby DA, Ghassemian M, Bandeira N, Komives EA. PMID: 24425750; PMCID: PMC3945911.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):19995-20002. Stalder D, Mizuno-Yamasaki E, Ghassemian M, Novick PJ. PMID: 24248333; PMCID: PMC3864272.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    30. A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. PMID: 23602409; PMCID: PMC3981467.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    31. Structure and interactions of the cytoplasmic domain of the Yersinia type III secretion protein YscD. J Bacteriol. 2012 Nov; 194(21):5949-58. Gamez A, Mukerjea R, Alayyoubi M, Ghassemian M, Ghosh P. PMID: 22942247; PMCID: PMC3486071.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    32. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS One. 2012; 7(8):e44041. Tomar A, Lawson C, Ghassemian M, Schlaepfer DD. PMID: 22952866; PMCID: PMC3430618.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. Reconstitution of abscisic acid activation of SLAC1 anion channel by CPK6 and OST1 kinases and branched ABI1 PP2C phosphatase action. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10593-8. Brandt B, Brodsky DE, Xue S, Negi J, Iba K, Kangasjärvi J, Ghassemian M, Stephan AB, Hu H, Schroeder JI. PMID: 22689970; PMCID: PMC3387046.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    34. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012 Apr; 122(4):1209-21. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. PMID: 22426213; PMCID: PMC3314469.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    35. Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. PMID: 21954290; PMCID: PMC4226136.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    36. Sequential interactions with Sec23 control the direction of vesicle traffic. Nature. 2011 May 12; 473(7346):181-6. Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S. PMID: 21532587; PMCID: PMC3093450.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    37. Automated querying and identification of novel peptides using MALDI mass spectrometric imaging. J Proteome Res. 2011 Apr 01; 10(4):1915-28. Bruand J, Sistla S, Mériaux C, Dorrestein PC, Gaasterland T, Ghassemian M, Wisztorski M, Fournier I, Salzet M, Macagno E, Bafna V. PMID: 21332220; PMCID: PMC4845900.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics. 2009 Nov; 9(22):5016-28. Guttman M, Betts GN, Barnes H, Ghassemian M, van der Geer P, Komives EA. PMID: 19771558; PMCID: PMC2862490.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    39. Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods. 2009 Aug; 6(8):596-9. Ng J, Bandeira N, Liu WT, Ghassemian M, Simmons TL, Gerwick WH, Linington R, Dorrestein PC, Pevzner PA. PMID: 19597502; PMCID: PMC2754211.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells