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    James Mckerrow

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentSchool of Pharmacy and Pharmaceutical Science
    Address9500 Gilman Drive #0657
    CA La Jolla 92093
    Phone858-822-7801
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      Collapse Research 
      Collapse Research Activities and Funding
      Novel antitrypanosomal alkaloids for Chagas disease
      NIH/NIAID R21AI128517Dec 7, 2016 - Nov 30, 2018
      Role: Principal Investigator
      Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
      NIH/NCATS UH2TR001369Jul 15, 2015 - May 31, 2016
      Role: Principal Investigator
      Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
      NIH/NIAID R01AI090605Jul 8, 2010 - Jun 30, 2015
      Role: Principal Investigator
      High Throughput Assay for Screening Compounds(RMI)
      NIH/NINDS R21NS053636Sep 30, 2005 - Aug 31, 2006
      Role: Principal Investigator
      Host Protein Degradation by Schistosome Parasites
      NIH/NIAID R01AI053247Jul 1, 2003 - Dec 31, 2008
      Role: Principal Investigator
      SEROLOGIC MARKER OF EXPOSURE TO SCHISTOSOME PARASITES
      NIH/NIAID R03AI041466Sep 30, 1997 - Aug 31, 1999
      Role: Principal Investigator
      Proteases in Cancer Biology and Drug Development
      NIH P01CA072006Jun 10, 1997 - Jun 30, 2010
      Role: Co-Investigator
      Predoctoral Training in Biomedical Sciences
      NIH/NIGMS T32GM008568Jul 1, 1995 - Jun 30, 2020
      Role: Principal Investigator
      Targeting Cysteine Proteases: Antiparasitic Chemotherapy
      NIH/NIAID P01AI035707May 1, 1995 - May 31, 2010
      Role: Principal Investigator
      UCSF Liver Core Center
      NIH P30DK026743Jul 1, 1985 - May 31, 2018
      Role: Co-Investigator
      CERCARIAL PROTEINASE OF SCHISTOSOMA MANSONI
      NIH/NIAID R01AI020452Jul 1, 1983 - Apr 30, 1998
      Role: Principal Investigator
      CHARACTERIZATION OF CERCARIAL PROTEINASE OF S MANSONI
      NIH/NIAID R22AI020452Jul 1, 1983 - Dec 31, 1989
      Role: Principal Investigator
      PROTEOLYTIC ACTIVITY OF THE LARVAE OF S. MANSONI
      NIH/NIAID R23AI020452Jul 1, 1983 - Jun 30, 1986
      Role: Principal Investigator
      Bio-Organic Biomedical Mass Spectrometry Resource
      NIH P41RR001614Mar 1, 1982 - May 31, 2015
      Role: Co-Investigator
      Resource for Biocomputing, Visualization, and Informatics
      NIH P41RR001081Jun 1, 1976 - Sep 14, 2012
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 Sep 22. PMID: 28892370.
        View in: PubMed
      2. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. PMID: 28704396.
        View in: PubMed
      3. McKerrow JH, Lipinski CA. The rule of five should not impede anti-parasitic drug development. Int J Parasitol Drugs Drug Resist. 2017 Aug; 7(2):248-249. PMID: 28623818.
        View in: PubMed
      4. Debnath A, McKerrow JH. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. PMID: 28421063.
        View in: PubMed
      5. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec; 10(12):e0005234. PMID: 28036391.
        View in: PubMed
      6. Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 Jan; 61(1). PMID: 27821451.
        View in: PubMed
      7. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 Feb 17; 12(2):422-434. PMID: 27977118.
        View in: PubMed
      8. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 Aug; 10(8):e0004893. PMID: 27501047; PMCID: PMC4976874.
      9. McCall LI, Siqueira-Neto JL, McKerrow JH. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 May; 12(5):e1005519. PMID: 27227827; PMCID: PMC4881934.
      10. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. PMID: 26876147; PMCID: PMC5003402 [Available on 05/01/17].
      11. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. PMID: 26751972; PMCID: PMC4709140.
      12. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. PMID: 26819670; PMCID: PMC4716606 [Available on 01/14/17].
      13. Urbina JA, McKerrow JH. Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrob Agents Chemother. 2015 Dec; 59(12):7923-4. PMID: 26578701; PMCID: PMC4649243.
      14. McKerrow JH. Recognition of the role of Natural Products as drugs to treat neglected tropical diseases by the 2015 Nobel prize in physiology or medicine. Nat Prod Rep. 2015 Dec 19; 32(12):1610-1. PMID: 26510605.
        View in: PubMed
      15. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. PMID: 26270237.
        View in: PubMed
      16. Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog. 2015 Jul; 11(7):e1005058. PMID: 26186534; PMCID: PMC4506092.
      17. Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. PLoS Negl Trop Dis. 2015; 9(7):e0003916. PMID: 26173110; PMCID: PMC4501791.
      18. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. PMID: 26114876; PMCID: PMC4482694.
      19. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. PMID: 26039195; PMCID: PMC4454677.
      20. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015; 6:368. PMID: 26029171; PMCID: PMC4429810.
      21. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. PMID: 25768284; PMCID: PMC4359151.
      22. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. PMID: 25712353; PMCID: PMC4394791.
      23. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363; PMCID: PMC4336141.
      24. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr; 116:76-84. PMID: 25666761; PMCID: PMC4774534.
      25. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312. PMID: 26477622.
        View in: PubMed
      26. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. PMID: 25393646; PMCID: PMC4266343.
      27. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-98. PMID: 25456815.
        View in: PubMed
      28. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. PMID: 25281737.
        View in: PubMed
      29. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. PMID: 25101801; PMCID: PMC4148169.
      30. McCall LI, McKerrow JH. Determinants of disease phenotype in trypanosomatid parasites. Trends Parasitol. 2014 Jul; 30(7):342-9. PMID: 24946952.
        View in: PubMed
      31. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. PMID: 24820073; PMCID: PMC4068574.
      32. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvorák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. PMID: 24676141; PMCID: PMC3967958.
      33. Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. ACS Med Chem Lett. 2014 Apr 10; 5(4):434-9. PMID: 24900854; PMCID: PMC4027616.
      34. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53. PMID: 24900788; PMCID: PMC4027639.
      35. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014; 58(3):1523-8. PMID: 24366747; PMCID: PMC3957901.
      36. Abdulla MH, Bakhiet M, Lejon V, Andersson J, McKerrow J, Al-Obeed O, Harris RA. TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection. PLoS One. 2013; 8(11):e79281. PMID: 24260185; PMCID: PMC3834137.
      37. Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. J Med Chem. 2013 Oct 10; 56(19):7651-68. PMID: 24079662; PMCID: PMC3864028.
      38. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. PMID: 24060869; PMCID: PMC3837922.
      39. Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. PLoS Negl Trop Dis. 2013; 7(8):e2370. PMID: 23991231; PMCID: PMC3750009.
      40. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. PMID: 23875031; PMCID: PMC3708847.
      41. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712. PMID: 23853713; PMCID: PMC3707081.
      42. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26; 76(4):630-41. PMID: 23445522; PMCID: PMC3971013.
      43. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. PMID: 23403423; PMCID: PMC3632933.
      44. Rascón AA, McKerrow JH. Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis. Curr Med Chem. 2013; 20(25):3078-102. PMID: 23514418.
        View in: PubMed
      45. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. PMID: 23181936; PMCID: PMC3566641.
      46. Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. PMID: 23236535; PMCID: PMC3516576.
      47. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov; 9(11):1095-100. PMID: 23023596; PMCID: PMC3707110.
      48. Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG. Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. PLoS One. 2012; 7(9):e46172. PMID: 23029428; PMCID: PMC3459870.
      49. Frevert U, Movila A, Nikolskaia OV, Raper J, Mackey ZB, Abdulla M, McKerrow J, Grab DJ. Early invasion of brain parenchyma by African trypanosomes. PLoS One. 2012; 7(8):e43913. PMID: 22952808; PMCID: PMC3432051.
      50. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog. 2012; 8(8):e1002883. PMID: 22927819; PMCID: PMC3426520.
      51. Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6256-60. PMID: 22926067.
        View in: PubMed
      52. Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012 Nov; 56(11):5450-7. PMID: 22869574; PMCID: PMC3486592.
      53. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736. PMID: 22860142; PMCID: PMC3409115.
      54. Pecoul B, Pollastri M, McKerrow J, Bueno-Calderon JM. Ask the experts. Future Med Chem. 2012 Jul; 4(11):1383-9. PMID: 22857528.
        View in: PubMed
      55. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. PMID: 22610278; PMCID: PMC3411919.
      56. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. PMID: 22539347; PMCID: PMC3375538.
      57. Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(4):e1589. PMID: 22509414; PMCID: PMC3317910.
      58. Marcellino C, Gut J, Lim KC, Singh R, McKerrow J, Sakanari J. WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl Trop Dis. 2012 Jan; 6(1):e1494. PMID: 22303493; PMCID: PMC3269415.
      59. Quezada LA, Sajid M, Lim KC, McKerrow JH. A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem. 2012 Mar 02; 287(10):7074-83. PMID: 22174417; PMCID: PMC3293575.
      60. Ben Khalaf N, De Muylder G, Louzir H, McKerrow J, Chenik M. Leishmania major protein disulfide isomerase as a drug target: enzymatic and functional characterization. Parasitol Res. 2012 May; 110(5):1911-7. PMID: 22160278.
        View in: PubMed
      61. Abdulla MH, Lim KC, McKerrow JH, Caffrey CR. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. PMID: 22039561; PMCID: PMC3201919.
      62. Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, McKerrow J. Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1337. PMID: 21980548; PMCID: PMC3181243.
      63. Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. The Trypanosoma cruzi protease cruzain mediates immune evasion. PLoS Pathog. 2011 Sep; 7(9):e1002139. PMID: 21909255; PMCID: PMC3164631.
      64. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. PMID: 21832058; PMCID: PMC3195637.
      65. Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Res. 2011 Nov; 92(2):187-94. PMID: 21820471; PMCID: PMC3205982.
      66. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. PMID: 21819989.
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      67. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul; 5(7):e1253. PMID: 21811648; PMCID: PMC3139667.
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      73. Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P. IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Sci Transl Med. 2010 Dec 01; 2(60):60ra88. PMID: 21123809.
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      75. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19; 4(10):e850. PMID: 20976050; PMCID: PMC2957409.
      76. Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH. Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem. 2010 Nov 15; 18(22):7826-35. PMID: 20961766.
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      77. Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. PLoS Negl Trop Dis. 2010 Sep 14; 4(9). PMID: 20856868; PMCID: PMC2939063.
      78. Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. J Biol Chem. 2010 Oct 08; 285(41):31120-9. PMID: 20675366; PMCID: PMC2951185.
      79. Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 08; 53(13):4891-905. PMID: 20540517; PMCID: PMC2895358.
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      81. Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother. 2010 Jun; 54(6):2480-8. PMID: 20385875; PMCID: PMC2876414.
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      84. Zhang S, Kim CC, Batra S, McKerrow JH, Loke P. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis. 2010 Mar 30; 4(3):e648. PMID: 20361029; PMCID: PMC2846935.
      85. Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P. Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorg Med Chem. 2010 Apr 01; 18(7):2566-74. PMID: 20303767; PMCID: PMC2893881.
      86. Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. J Med Chem. 2010 Feb 25; 53(4):1763-73. PMID: 20088534; PMCID: PMC2838180.
      87. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14; 53(1):52-60. PMID: 19908842; PMCID: PMC2804034.
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      91. Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell. 2009 Nov; 8(11):1665-76. PMID: 19749174; PMCID: PMC2772394.
      92. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. PMID: 19773167; PMCID: PMC3760505.
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      106. Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH. Metal compounds for the treatment of parasitic diseases. J Inorg Biochem. 2008 Oct; 102(10):1839-45. PMID: 18684510.
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      108. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31. PMID: 18445589; PMCID: PMC2440617.
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      111. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. PMID: 18420405; PMCID: PMC2435229.
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      129. Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ. The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 01; 194(11):1609-16. PMID: 17083048; PMCID: PMC2853799.
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      131. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. PMID: 16987516.
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      133. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. PMID: 16895475.
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      148. Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004 Sep 15; 173(6):4020-9. PMID: 15356151.
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      149. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12; 279(46):48426-33. PMID: 15326171.
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      150. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug; 136(2):227-42. PMID: 15478801.
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      151. Debnath A, Das P, Sajid M, McKerrow JH. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. PMID: 15243916.
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      152. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7. PMID: 15199048.
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      153. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. PMID: 15163200.
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      154. Caffrey CR, McKerrow JH, Salter JP, Sajid M. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. PMID: 15105025.
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      155. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. PMID: 15055989.
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      156. Mahmoudzadeh-Niknam H, McKerrow JH. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol. 2004 Mar-Apr; 106(3-4):158-63. PMID: 15172223.
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      157. Hernandez DC, Lim KC, McKerrow JH, Davies SJ. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Exp Parasitol. 2004 Jan-Feb; 106(1-2):59-61. PMID: 15013791; PMCID: PMC2891232.
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      159. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. PMID: 14719804.
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      160. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. PMID: 14505663.
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      161. Davies SJ, McKerrow JH. Developmental plasticity in schistosomes and other helminths. Int J Parasitol. 2003 Sep 30; 33(11):1277-84. PMID: 13678642; PMCID: PMC2891239.
      162. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. PMID: 12967713.
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      163. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. PMID: 12927956.
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      164. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. PMID: 12595442; PMCID: PMC148873.
      165. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003; 6(4):272-80. PMID: 14663466.
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      166. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. PMID: 12061873.
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      167. Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 03; 12(11):1537-41. PMID: 12031337.
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      168. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 05; 277(27):24618-24. PMID: 11986325.
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      169. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. PMID: 11985866.
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      170. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. PMID: 11985862.
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      171. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. PMID: 11932146.
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      172. Sajid M, McKerrow JH. Cysteine proteases of parasitic organisms. Mol Biochem Parasitol. 2002 Mar; 120(1):1-21. PMID: 11849701.
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      173. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. PMID: 11755183.
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      174. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 09; 294(5545):1358-61. PMID: 11701932.
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      175. Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. FEBS Lett. 2001 Nov 02; 507(3):362-6. PMID: 11696372.
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      176. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. PMID: 11704274.
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      177. Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorg Med Chem Lett. 2001 Oct 22; 11(20):2759-62. PMID: 11591518.
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      178. Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N. Identification, cloning, and recombinant expression of procalin, a major triatomine allergen. J Immunol. 2001 Sep 01; 167(5):2694-9. PMID: 11509613.
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      179. Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. J Biol Chem. 2000 Dec 08; 275(49):38667-73. PMID: 10993899.
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      180. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. PMID: 10980453.
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      181. Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Mol Med. 2000 Aug; 6(8):660-9. PMID: 11055585; PMCID: PMC1949976.
      182. Brinen LS, Que X, McKerrow JH, Reed SL. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S63-4. PMID: 11070225.
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      183. McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R. A functional proteomics screen of proteases in colorectal carcinoma. Mol Med. 2000 May; 6(5):450-60. PMID: 10952024; PMCID: PMC1949953.
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      185. Stoka V, Turk B, McKerrow JH, Björk I, Cazzulo JJ, Turk V. The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain. FEBS Lett. 2000 Mar 03; 469(1):29-32. PMID: 10708750.
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      186. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. PMID: 10682836.
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      187. Loer CM, Davidson B, Mckerrow J. A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis. J Neurogenet. 1999 Nov; 13(3):157-80. PMID: 10928216.
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      188. Britton C, Redmond DL, Knox DP, McKerrow JH, Barry JD. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Mol Biochem Parasitol. 1999 Oct 15; 103(2):171-81. PMID: 10551361.
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      189. Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, McKerrow JH. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11015-22. PMID: 10500116; PMCID: PMC34234.
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      192. Chan VJ, Selzer PM, McKerrow JH, Sakanari JA. Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. Biochem J. 1999 May 15; 340 ( Pt 1):113-7. PMID: 10229665; PMCID: PMC1220228.
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      194. Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei. Exp Parasitol. 1999 Apr; 91(4):349-55. PMID: 10092479.
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      196. Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors. Bioorg Med Chem. 1998 Dec; 6(12):2477-94. PMID: 9925304.
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      197. Roush WR, González FV, McKerrow JH, Hansell E. Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain. Bioorg Med Chem Lett. 1998 Oct 06; 8(19):2809-12. PMID: 9873627.
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      200. Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J Cell Sci. 1998 Mar; 111 ( Pt 5):597-606. PMID: 9454733.
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      201. Britton C, McKerrow JH, Johnstone IL. Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. J Mol Biol. 1998; 283(1):15-27. PMID: 9761670.
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      202. Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH. Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp Parasitol. 1997 Nov; 87(3):212-21. PMID: 9371086.
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      203. Hagen HE, Kläger SL, McKerrow JH, Ham PJ. Simulium damnosum s.l.: isolation and identification of prophenoloxidase following an infection with Onchocerca spp. using targeted differential display. Exp Parasitol. 1997 Jul; 86(3):213-8. PMID: 9225772.
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      204. Ward W, Alvarado L, Rawlings ND, Engel JC, Franklin C, McKerrow JH. A primitive enzyme for a primitive cell: the protease required for excystation of Giardia. Cell. 1997 May 02; 89(3):437-44. PMID: 9150143.
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      205. Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb; 65(2):767-73. PMID: 9009340; PMCID: PMC176123.
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      207. Leptak CL, McKerrow JH. Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation. J Immunol. 1997 Jan 01; 158(1):301-7. PMID: 8977203.
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      208. Lustigman S, McKerrow JH, Shah K, Lui J, Huima T, Hough M, Brotman B. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. J Biol Chem. 1996 Nov 22; 271(47):30181-9. PMID: 8939969.
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      209. Ritter DM, McKerrow JH. Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation. Infect Immun. 1996 Nov; 64(11):4706-13. PMID: 8890229; PMCID: PMC174435.
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      211. Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep; 4(9):1421-7. PMID: 8894100.
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      212. Ghendler Y, Parizade M, Arnon R, McKerrow JH, Fishelson Z. Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula. Exp Parasitol. 1996 Jun; 83(1):73-82. PMID: 8654554.
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      213. Hagen HE, Kläger SL, Chan V, Sakanari JA, McKerrow JH, Ham PJ. Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR. Exp Parasitol. 1995 Nov; 81(3):249-54. PMID: 7498421.
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      216. Brindley PJ, Gam AA, McKerrow JH, Neva FA. Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. Exp Parasitol. 1995 Feb; 80(1):1-7. PMID: 7529715.
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      217. Mitro K, Bhagavathiammai A, Zhou OM, Bobbett G, McKerrow JH, Chokshi R, Chokshi B, James ER. Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol. 1994 Jun; 78(4):377-85. PMID: 8206136.
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      218. Aldape K, Huizinga H, Bouvier J, McKerrow J. Naegleria fowleri: characterization of a secreted histolytic cysteine protease. Exp Parasitol. 1994 Mar; 78(2):230-41. PMID: 8119377.
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      219. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3583-7. PMID: 8475107; PMCID: PMC46345.
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      221. Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH. Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Mol Biochem Parasitol. 1993 Mar; 58(1):17-24. PMID: 8459830.
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      222. Hong X, Bouvier J, Wong MM, Yamagata GY, McKerrow JH. Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Exp Parasitol. 1993 Mar; 76(2):127-33. PMID: 8454021.
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      224. Clawson GA, Norbeck LL, Hatem CL, Rhodes C, Amiri P, McKerrow JH, Patierno SR, Fiskum G. Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38. PMID: 1467310.
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      225. Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992 Aug 25; 267(24):17339-46. PMID: 1512269.
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      226. Fishelson Z, Amiri P, Friend DS, Marikovsky M, Petitt M, Newport G, McKerrow JH. Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae. Exp Parasitol. 1992 Aug; 75(1):87-98. PMID: 1639166.
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      227. Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. J Biol Chem. 1992 Apr 15; 267(11):7411-20. PMID: 1559982.
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      228. Ray C, McKerrow JH. Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Mol Biochem Parasitol. 1992 Apr; 51(2):239-49. PMID: 1574082.
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      229. Jacques C, Richmond G, Tierney L, Curtis JL, McKerrow J, Warnock ML. Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man. Hum Pathol. 1992 Feb; 23(2):191-4. PMID: 1740304.
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      230. McKerrow JH. Pathogenesis in amebiasis: is it genetic or acquired? Infect Agents Dis. 1992 Feb; 1(1):11-4. PMID: 1365521.
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      232. Cohen FE, Gregoret LM, Amiri P, Aldape K, Railey J, McKerrow JH. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry. 1991 Nov 26; 30(47):11221-9. PMID: 1958659.
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      234. Brown M, Reed S, Levy JA, Busch M, McKerrow JH. Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells. AIDS. 1991 Jan; 5(1):93-6. PMID: 2059366.
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      235. Keene WE, Hidalgo ME, Orozco E, McKerrow JH. Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990 Aug; 71(2):199-206. PMID: 2373188.
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      236. Resnick S, Zimmer B, Pappagianis D, Eakin A, McKerrow J. Purification and amino-terminal sequence analysis of the complement-fixing and precipitin antigens from Coccidioides immitis. J Clin Microbiol. 1990 Feb; 28(2):385-8. PMID: 2312685; PMCID: PMC269617.
      237. McKerrow JH, Brindley P, Brown M, Gam AA, Staunton C, Neva FA. Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. Exp Parasitol. 1990 Feb; 70(2):134-43. PMID: 2137091.
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      239. Hidalgo ME, Hernández R, Keene WE, McKerrow JH, Orozco E. [Direct relation between secretion of proteolytic enzymes and virulence in Entamoeba histolytica]. Arch Invest Med (Mex). 1990; 21 Suppl 1:133-8. PMID: 2136478.
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      240. Reed SL, Keene WE, McKerrow JH. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989 Dec; 27(12):2772-7. PMID: 2556432; PMCID: PMC267124.
      241. Apodaca G, McKerrow JH. Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infect Immun. 1989 Oct; 57(10):3072-80. PMID: 2674015; PMCID: PMC260772.
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      243. Reed SL, Keene WE, McKerrow JH, Gigli I. Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica. J Immunol. 1989 Jul 01; 143(1):189-95. PMID: 2543700.
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