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James Mckerrow

Title(s)Dean, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #0657
La Jolla CA 92093
Phone8/8-22--7801
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    Collapse Research 
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    Novel antitrypanosomal alkaloids for Chagas disease
    NIH/NIAID R21AI128517Dec 7, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
    NIH/NCATS UH2TR001369Jul 15, 2015 - May 31, 2016
    Role: Principal Investigator
    Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    NIH/NIAID R01AI090605Jul 8, 2010 - Jun 30, 2015
    Role: Principal Investigator
    High Throughput Assay for Screening Compounds(RMI)
    NIH/NINDS R21NS053636Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Host Protein Degradation by Schistosome Parasites
    NIH/NIAID R01AI053247Jul 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 1, 1998 - Nov 30, 2002
    Role: Co-Investigator
    SEROLOGIC MARKER OF EXPOSURE TO SCHISTOSOME PARASITES
    NIH/NIAID R03AI041466Sep 30, 1997 - Aug 31, 1999
    Role: Principal Investigator
    UCSF Liver Center
    NIH/NIDDK P30DK026743Dec 1, 1996 - Nov 30, 2000
    Role: Co-Investigator
    Predoctoral Training in Biomedical Sciences
    NIH/NIGMS T32GM008568Jul 1, 1995 - Mar 31, 2005
    Role: Principal Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH/NIAID P01AI035707May 1, 1995 - May 31, 2010
    Role: Principal Investigator
    CERCARIAL PROTEINASE OF SCHISTOSOMA MANSONI
    NIH/NIAID R01AI020452Jul 1, 1983 - Dec 31, 1989
    Role: Principal Investigator
    CHARACTERIZATION OF CERCARIAL PROTEINASE OF S MANSONI
    NIH/NIAID R22AI020452Jul 1, 1983 - Dec 31, 1989
    Role: Principal Investigator
    PROTEOLYTIC ACTIVITY OF THE LARVAE OF S. MANSONI
    NIH/NIAID R23AI020452Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLoS Negl Trop Dis. 2020 Sep 24; 14(9):e0008726. Calvet CM, Silva TA, Thomas D, Suzuki B, Hirata K, Siqueira-Neto JL, McKerrow JH. PMID: 32970692.
      View in: PubMed   Mentions:    Fields:    
    2. Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. PLoS Negl Trop Dis. 2020 05; 14(5):e0007980. Wozniak JM, Silva TA, Thomas D, Siqueira-Neto JL, McKerrow JH, Gonzalez DJ, Calvet CM. PMID: 32433643.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2020 04 21; 64(5). Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. PMID: 32094126.
      View in: PubMed   Mentions: 1     Fields:    
    4. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020 Mar 26; 8(4). Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. PMID: 32224991.
      View in: PubMed   Mentions:
    5. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem. 2020 03 26; 63(6):3298-3316. Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PMID: 32125159.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):180-185. Carter DS, Jacobs RT, Freund YR, Berry PW, Akama T, Easom EE, Lunde CS, Rock F, Stefanakis R, McKerrow J, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Sakanari JA, Lustigman S, Plattner JJ. PMID: 31876143.
      View in: PubMed   Mentions:    Fields:    
    7. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):173-179. Akama T, Freund YR, Berry PW, Carter DS, Easom EE, Jarnagin K, Lunde CS, Plattner JJ, Rock F, Stefanakis R, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Mansour A, DiCosty U, McCall S, Carson B, McCall JW, McKerrow J, Hübner MP, Specht S, Hoerauf A, Lustigman S, Sakanari JA, Jacobs RT. PMID: 31876154.
      View in: PubMed   Mentions: 1     Fields:    
    8. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):249-257. Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. PMID: 32184953.
      View in: PubMed   Mentions:
    9. Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol ?8-?7-Isomerase and Phenotypic Assays. ACS Infect Dis. 2019 12 13; 5(12):2029-2038. Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. PMID: 31583882.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. PLoS Negl Trop Dis. 2018 10; 12(10):e0006923. Rebello KM, McKerrow JH, Mota EM, O'Donoghue AJ, Neves-Ferreira AGC. PMID: 30379807.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data. Sci Rep. 2018 08 30; 8(1):13092. White Bear J, Long T, Skinner D, McKerrow JH. PMID: 30166569.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Update on drug development targeting parasite cysteine proteases. PLoS Negl Trop Dis. 2018 08; 12(8):e0005850. McKerrow JH. PMID: 30138309.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. The diverse roles of cysteine proteases in parasites and their suitability as drug targets. PLoS Negl Trop Dis. 2018 08; 12(8):e0005639. McKerrow JH. PMID: 30138311.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    14. Why Funding for Neglected Tropical Diseases Should Be a Global Priority. Clin Infect Dis. 2018 07 18; 67(3):323-326. Reed SL, McKerrow JH. PMID: 29688342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    15. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
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    16. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. PMID: 29565998.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    17. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol. 2018 May; 188:36-41. Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. PMID: 29551628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri. Front Microbiol. 2018; 9:414. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. PMID: 29559968.
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    19. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132. Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. PMID: 29281643.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 10 03; 89(19):10414-10421. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. PMID: 28892370.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    22. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. The rule of five should not impede anti-parasitic drug development. Int J Parasitol Drugs Drug Resist. 2017 08; 7(2):248-249. McKerrow JH, Lipinski CA. PMID: 28623818.
      View in: PubMed   Mentions: 3     Fields:    
    24. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. Debnath A, McKerrow JH. PMID: 28421063.
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    25. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 12; 10(12):e0005234. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. PMID: 28036391.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    26. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. PMID: 27821451.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCTClinical Trials
    27. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 02 17; 12(2):422-434. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. PMID: 27977118.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    29. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 05; 12(5):e1005519. McCall LI, Siqueira-Neto JL, McKerrow JH. PMID: 27227827.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    30. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. PMID: 26876147.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    31. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. PMID: 26751972.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    32. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. PMID: 26819670.
      View in: PubMed   Mentions:
    33. Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrob Agents Chemother. 2015 Dec; 59(12):7923-4. Urbina JA, McKerrow JH. PMID: 26578701.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Recognition of the role of Natural Products as drugs to treat neglected tropical diseases by the 2015 Nobel prize in physiology or medicine. Nat Prod Rep. 2015 Dec 19; 32(12):1610-1. McKerrow JH. PMID: 26510605.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    35. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. PMID: 26270237.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    36. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog. 2015 Jul; 11(7):e1005058. Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. PMID: 26186534.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. PLoS Negl Trop Dis. 2015; 9(7):e0003916. Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. PMID: 26173110.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    38. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    39. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. PMID: 26039195.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015; 6:368. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. PMID: 26029171.
      View in: PubMed   Mentions:
    41. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    43. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    44. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr; 116:76-84. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. PMID: 25666761.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    45. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. PMID: 26477622.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    46. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    47. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-1798. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. PMID: 25456815.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    48. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    49. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    50. Determinants of disease phenotype in trypanosomatid parasites. Trends Parasitol. 2014 Jul; 30(7):342-9. McCall LI, McKerrow JH. PMID: 24946952.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    51. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. PMID: 24820073.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    52. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvorák J. PMID: 24676141.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    53. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. ACS Med Chem Lett. 2014 Apr 10; 5(4):434-9. Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. PMID: 24900854.
      View in: PubMed   Mentions:
    54. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. PMID: 24900788.
      View in: PubMed   Mentions:
    55. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014; 58(3):1523-8. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. PMID: 24366747.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection. PLoS One. 2013; 8(11):e79281. Abdulla MH, Bakhiet M, Lejon V, Andersson J, McKerrow J, Al-Obeed O, Harris RA. PMID: 24260185.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCTClinical Trials
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    124. Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e262. Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. PMID: 18629379.
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    125. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5860-3. Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. PMID: 18585034.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    126. Metal compounds for the treatment of parasitic diseases. J Inorg Biochem. 2008 Oct; 102(10):1839-45. Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH. PMID: 18684510.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    127. Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Mol Biochem Parasitol. 2008 Aug; 160(2):129-37. Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH. PMID: 18554733.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    128. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. PMID: 18445589.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    129. Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc. 2008 May 21; 130(20):6404-10. Brak K, Doyle PS, McKerrow JH, Ellman JA. PMID: 18435536.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    130. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 08; 51(9):2816-32. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. PMID: 18416543.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    131. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. PMID: 18420405.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    132. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. PMID: 18173229.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    133. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. PMID: 18160404.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    134. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):624-8. Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. PMID: 18055204.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    135. Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6697-700. González FV, Izquierdo J, Rodríguez S, McKerrow JH, Hansell E. PMID: 17977725.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    136. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. PMID: 17936488.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    137. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov; 51(11):3932-9. Doyle PS, Zhou YM, Engel JC, McKerrow JH. PMID: 17698625.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    138. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 04; 581(22):4260-4. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. PMID: 17707374.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    139. Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions. Mol Immunol. 2008 Jan; 45(2):567-74. Aslam A, Quinn P, McIntosh RS, Shi J, Ghumra A, McKerrow JH, Bunting KA, Dunne DW, Doenhoff MJ, Morrison SL, Zhang K, Pleass RJ. PMID: 17631966.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    140. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. PMID: 17513563.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    141. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    142. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH. PMID: 17451823.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    143. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. PMID: 17371810.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    144. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul; 37(8-9):897-906. Debnath A, Tashker JS, Sajid M, McKerrow JH. PMID: 17362964.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    145. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. PMID: 17336985.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    146. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan; 4(1):e14. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. PMID: 17214506.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    147. Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol. 2007; 8(4):R65. Jolly ER, Chin CS, Miller S, Bahgat MM, Lim KC, DeRisi J, McKerrow JH. PMID: 17456242.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    148. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006 Dec; 2(12):701-10. Renslo AR, McKerrow JH. PMID: 17108988.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    149. The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 01; 194(11):1609-16. Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ. PMID: 17083048.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    150. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22; 281(51):39316-29. Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. PMID: 17028179.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    151. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. PMID: 16987516.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    152. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. PMID: 16895475.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    153. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    154. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des. 2006 May; 67(5):355-63. Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. PMID: 16784460.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    155. Giardia lamblia cysteine proteases. Parasitol Res. 2006 Sep; 99(4):313-6. DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. PMID: 16598471.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    156. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. PMID: 16516467.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    157. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. PMID: 18039124.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    158. Designing drugs for parasitic diseases of the developing world. PLoS Med. 2005 Aug; 2(8):e210. McKerrow JH. PMID: 16120007.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    159. Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics. 2005 Dec; 4(12):1862-75. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. PMID: 16112986.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    160. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. PMID: 15950230.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    161. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. PMID: 15964982.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    162. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. PMID: 15899696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    163. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. PMID: 15862572.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    164. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. PMID: 15582423.
      View in: PubMed   Mentions: 16     Fields:    
    165. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 01; 12(19):5203-11. Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. PMID: 15351403.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    166. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004 Sep 15; 173(6):4020-9. Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA. PMID: 15356151.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    167. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12; 279(46):48426-33. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. PMID: 15326171.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    168. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug; 136(2):227-42. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. PMID: 15478801.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    169. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. Debnath A, Das P, Sajid M, McKerrow JH. PMID: 15243916.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    170. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. PMID: 15199048.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    171. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    172. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. Caffrey CR, McKerrow JH, Salter JP, Sajid M. PMID: 15105025.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    173. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 15055989.
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    174. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Exp Parasitol. 2004 Jan-Feb; 106(1-2):59-61. Hernandez DC, Lim KC, McKerrow JH, Davies SJ. PMID: 15013791.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    175. Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. Int J Parasitol. 2004 Jan; 34(1):27-36. Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH. PMID: 14711587.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    176. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. PMID: 14719804.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    177. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 14505663.
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    178. Developmental plasticity in schistosomes and other helminths. Int J Parasitol. 2003 Sep 30; 33(11):1277-84. Davies SJ, McKerrow JH. PMID: 13678642.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    179. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. PMID: 12967713.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    180. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. PMID: 12927956.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    181. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. PMID: 12595442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    182. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. PMID: 12061873.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    183. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 03; 12(11):1537-41. Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. PMID: 12031337.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    184. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 05; 277(27):24618-24. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. PMID: 11986325.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    185. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. PMID: 11985862.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    186. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    187. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. PMID: 11932146.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    188. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. PMID: 11755183.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
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