James Mckerrow

Title(s)Emeritus Professor, School of Pharmacy and Pharmaceutical Science
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
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    Novel antitrypanosomal alkaloids for Chagas disease
    NIH R21AI128517Dec 7, 2016 - Nov 30, 2019
    Role: Principal Investigator
    Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
    NIH UH2TR001369Jul 15, 2015 - May 31, 2016
    Role: Principal Investigator
    Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    NIH R01AI090605Jul 8, 2010 - Jun 30, 2016
    Role: Principal Investigator
    High Throughput Assay for Screening Compounds(RMI)
    NIH R21NS053636Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Host Protein Degradation by Schistosome Parasites
    NIH R01AI053247Jul 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    SEROLOGIC MARKER OF EXPOSURE TO SCHISTOSOME PARASITES
    NIH R03AI041466Sep 30, 1997 - Aug 31, 1999
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Co-Investigator
    Predoctoral Training in Biomedical Sciences
    NIH T32GM008568Jul 1, 1995 - Aug 31, 2020
    Role: Principal Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH P01AI035707May 1, 1995 - May 31, 2010
    Role: Principal Investigator
    UCSF Liver Center
    NIH P30DK026743Jul 1, 1985 - May 31, 2023
    Role: Co-Investigator
    CERCARIAL PROTEINASE OF SCHISTOSOMA MANSONI
    NIH R01AI020452Jul 1, 1983 - Apr 30, 1998
    Role: Principal Investigator
    CHARACTERIZATION OF CERCARIAL PROTEINASE OF S MANSONI
    NIH R22AI020452Jul 1, 1983 - Dec 31, 1989
    Role: Principal Investigator
    PROTEOLYTIC ACTIVITY OF THE LARVAE OF S. MANSONI
    NIH R23AI020452Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines. Parasitol Res. 2023 Dec; 122(12):2751-2772. Saidu U, Ibrahim MA, de Koning HP, McKerrow JH, Caffrey CR, Balogun EO. PMID: 37851179.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors. Future Med Chem. 2023 06; 15(11):959-985. Maltarollo VG, da Silva EB, Kronenberger T, Sena Andrade MM, de Lima Marques GV, Cândido Oliveira NJ, Santos LH, Oliveira Rezende Júnior C, Cassiano Martinho AC, Skinner D, Fajtová P, M Fernandes TH, Silveira Dos Santos ED, Rodrigues Gazolla PA, Martins de Souza AP, da Silva ML, Dos Santos FS, Lavorato SN, Oliveira Bretas AC, Carvalho DT, Franco LL, Luedtke S, Giardini MA, Poso A, Dias LC, Podust LM, Alves RJ, McKerrow J, Andrade SF, Teixeira RR, Siqueira-Neto JL, O'Donoghue A, de Oliveira RB, Ferreira RS. PMID: 37435731.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Discovery of pyrazolopyrrolidinones as potent, broad-spectrum inhibitors of Leishmania infection. Front Trop Dis. 2023; 3. Kavouris JA, McCall LI, Giardini MA, De Muylder G, Thomas D, Garcia-Pérez A, Cantizani J, Cotillo I, Fiandor JM, McKerrow JH, De Oliveira CI, Siqueira-Neto JL, González S, Brown LE, Schaus SE. PMID: 36818551; PMCID: PMC9937549.
      View in: PubMed   Mentions: 1  
    4. Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2. J Chem Inf Model. 2022 12 26; 62(24):6553-6573. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35960688.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    5. Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. J Med Chem. 2022 07 14; 65(13):9376-9395. Pillaiyar T, Flury P, Krüger N, Su H, Schäkel L, Barbosa Da Silva E, Eppler O, Kronenberger T, Nie T, Luedtke S, Rocha C, Sylvester K, Petry MRI, McKerrow JH, Poso A, Pöhlmann S, Gütschow M, O'Donoghue AJ, Xu Y, Müller CE, Laufer SA. PMID: 35709506.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L. Pharmaceuticals (Basel). 2022 Jun 13; 15(6). Meewan I, Kattoula J, Kattoula JY, Skinner D, Fajtová P, Giardini MA, Woodworth B, McKerrow JH, Lage de Siqueira-Neto J, O'Donoghue AJ, Abagyan R. PMID: 35745663; PMCID: PMC9230533.
      View in: PubMed   Mentions: 6  
    7. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi. J Med Chem. 2022 03 10; 65(5):4255-4269. Barbosa Da Silva E, Sharma V, Hernandez-Alvarez L, Tang AH, Stoye A, O'Donoghue AJ, Gerwick WH, Payne RJ, McKerrow JH, Podust LM. PMID: 35188371.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    8. Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents against Trypanosoma cruzi. ACS Omega. 2022 Mar 08; 7(9):7675-7682. Bernatchez JA, Kil YS, Barbosa da Silva E, Thomas D, McCall LI, Wendt KL, Souza JM, Ackermann J, McKerrow JH, Cichewicz RH, Siqueira-Neto JL. PMID: 35284725; PMCID: PMC8908367.
      View in: PubMed   Mentions:
    9. Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2. bioRxiv. 2022 Jan 05. Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, Siqueira-Neto JL, O'Donoghue AJ, da Silva Júnior EN, Ferreira RS. PMID: 35018373; PMCID: PMC8750648.
      View in: PubMed   Mentions:
    10. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2022 02 24; 65(4):2956-2970. Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 34730959; PMCID: PMC8577376.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    11. Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease. PLoS Negl Trop Dis. 2021 10; 15(10):e0009819. Dean DA, Gautham G, Siqueira-Neto JL, McKerrow JH, Dorrestein PC, McCall LI. PMID: 34606502; PMCID: PMC8516257.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    12. Structure-Based Optimization of Quinazolines as Cruzain and TbrCATL Inhibitors. J Med Chem. 2021 09 09; 64(17):13054-13071. Barbosa da Silva E, Rocha DA, Fortes IS, Yang W, Monti L, Siqueira-Neto JL, Caffrey CR, McKerrow J, Andrade SF, Ferreira RS. PMID: 34461718.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Acanthamoeba Keratitis: an update on amebicidal and cysticidal drug screening methodologies and potential treatment with azole drugs. Expert Rev Anti Infect Ther. 2021 11; 19(11):1427-1441. Shing B, Balen M, McKerrow JH, Debnath A. PMID: 33929276; PMCID: PMC8551003.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    14. Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by Leishmania major in Experimental Murine Models. Pathogens. 2021 May 13; 10(5). Parab AR, Thomas D, Lostracco-Johnson S, Siqueira-Neto JL, McKerrow JH, Dorrestein PC, McCall LI. PMID: 34068119; PMCID: PMC8152770.
      View in: PubMed   Mentions: 5  
    15. Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases. Bioorg Med Chem. 2021 07 01; 41:116213. Silva LR, Guimarães AS, do Nascimento J, do Santos Nascimento IJ, da Silva EB, McKerrow JH, Cardoso SH, da Silva-Júnior EF. PMID: 33992862.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells. ACS Chem Biol. 2021 04 16; 16(4):642-650. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Kocurek KI, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Yoon MC, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Hook V, Frueh F, Hurst BL, Wang H, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33787221.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    17. First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua. PLoS One. 2021; 16(1):e0246084. Huete-Pérez JA, Cabezas-Robelo C, Páiz-Medina L, Hernández-Álvarez CA, Quant-Durán C, McKerrow JH. PMID: 33503071; PMCID: PMC7840011.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    18. An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease. Pathogens. 2021 Jan 14; 10(1). Tyagi R, Bulman CA, Cho-Ngwa F, Fischer C, Marcellino C, Arkin MR, McKerrow JH, McNamara CW, Mahoney M, Tricoche N, Jawahar S, Janetka JW, Lustigman S, Sakanari J, Mitreva M. PMID: 33466870; PMCID: PMC7830784.
      View in: PubMed   Mentions: 7  
    19. Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L. bioRxiv. 2020 Dec 24. Ashhurst AS, Tang AH, Fajtová P, Yoon M, Aggarwal A, Stoye A, Larance M, Beretta L, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CK, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. PMID: 33398273; PMCID: PMC7781308.
      View in: PubMed   Mentions: 2  
    20. A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells. bioRxiv. 2020 Oct 30. Mellott DM, Tseng CT, Drelich A, Fajtová P, Chenna BC, Kostomiris DH, Hsu J, Zhu J, Taylor ZW, Tat V, Katzfuss A, Li L, Giardini MA, Skinner D, Hirata K, Beck S, Carlin AF, Clark AE, Beretta L, Maneval D, Frueh F, Hurst BL, Wang H, Kocurek KI, Raushel FM, O'Donoghue AJ, de Siqueira-Neto JL, Meek TD, McKerrow JH. PMID: 33140046; PMCID: PMC7605553.
      View in: PubMed   Mentions: 1  
    21. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLoS Negl Trop Dis. 2020 09; 14(9):e0008726. Calvet CM, Silva TA, Thomas D, Suzuki B, Hirata K, Siqueira-Neto JL, McKerrow JH. PMID: 32970692; PMCID: PMC7561097.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    22. Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. PLoS Negl Trop Dis. 2020 05; 14(5):e0007980. Wozniak JM, Silva TA, Thomas D, Siqueira-Neto JL, McKerrow JH, Gonzalez DJ, Calvet CM. PMID: 32433643; PMCID: PMC7279607.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2020 04 21; 64(5). Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. PMID: 32094126; PMCID: PMC7179639.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    24. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020 Mar 26; 8(4). Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. PMID: 32224991; PMCID: PMC7232187.
      View in: PubMed   Mentions: 9  
    25. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem. 2020 03 26; 63(6):3298-3316. Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PMID: 32125159; PMCID: PMC7261474.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):180-185. Carter DS, Jacobs RT, Freund YR, Berry PW, Akama T, Easom EE, Lunde CS, Rock F, Stefanakis R, McKerrow J, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Sakanari JA, Lustigman S, Plattner JJ. PMID: 31876143; PMCID: PMC7026882.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    27. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):173-179. Akama T, Freund YR, Berry PW, Carter DS, Easom EE, Jarnagin K, Lunde CS, Plattner JJ, Rock F, Stefanakis R, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Mansour A, DiCosty U, McCall S, Carson B, McCall JW, McKerrow J, Hübner MP, Specht S, Hoerauf A, Lustigman S, Sakanari JA, Jacobs RT. PMID: 31876154; PMCID: PMC7026885.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    28. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):249-257. Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. PMID: 32184953; PMCID: PMC7073875.
      View in: PubMed   Mentions: 14  
    29. Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol Δ8-Δ7-Isomerase and Phenotypic Assays. ACS Infect Dis. 2019 12 13; 5(12):2029-2038. Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. PMID: 31583882; PMCID: PMC7085920.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    30. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. PLoS Negl Trop Dis. 2018 10; 12(10):e0006923. Rebello KM, McKerrow JH, Mota EM, O'Donoghue AJ, Neves-Ferreira AGC. PMID: 30379807; PMCID: PMC6231675.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data. Sci Rep. 2018 08 30; 8(1):13092. White Bear J, Long T, Skinner D, McKerrow JH. PMID: 30166569; PMCID: PMC6117258.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    32. Update on drug development targeting parasite cysteine proteases. PLoS Negl Trop Dis. 2018 08; 12(8):e0005850. McKerrow JH. PMID: 30138309; PMCID: PMC6107105.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    33. The diverse roles of cysteine proteases in parasites and their suitability as drug targets. PLoS Negl Trop Dis. 2018 08; 12(8):e0005639. McKerrow JH. PMID: 30138311; PMCID: PMC6107102.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    34. Why Funding for Neglected Tropical Diseases Should Be a Global Priority. Clin Infect Dis. 2018 07 18; 67(3):323-326. Reed SL, McKerrow JH. PMID: 29688342.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansPHPublic Health
    35. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596; PMCID: PMC5917446.
      View in: PubMed   Mentions: 9  
    36. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. PMID: 29565998; PMCID: PMC5863946.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    37. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol. 2018 May; 188:36-41. Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. PMID: 29551628; PMCID: PMC5918159.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    38. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri. Front Microbiol. 2018; 9:414. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. PMID: 29559968; PMCID: PMC5845744.
      View in: PubMed   Mentions: 19  
    39. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029; PMCID: PMC5746216.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    40. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132. Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. PMID: 29281643; PMCID: PMC5744913.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    41. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 10 03; 89(19):10414-10421. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. PMID: 28892370; PMCID: PMC6298790.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    42. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396; PMCID: PMC5526615.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    43. The rule of five should not impede anti-parasitic drug development. Int J Parasitol Drugs Drug Resist. 2017 08; 7(2):248-249. McKerrow JH, Lipinski CA. PMID: 28623818; PMCID: PMC5473536.
      View in: PubMed   Mentions: 18     Fields:    
    44. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. Debnath A, McKerrow JH. PMID: 28421063; PMCID: PMC5379777.
      View in: PubMed   Mentions:
    45. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 12; 10(12):e0005234. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. PMID: 28036391; PMCID: PMC5201425.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    46. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. PMID: 27821451; PMCID: PMC5192119.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCTClinical Trials
    47. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 02 17; 12(2):422-434. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. PMID: 27977118; PMCID: PMC5649375.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    48. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047; PMCID: PMC4976874.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    49. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 05; 12(5):e1005519. McCall LI, Siqueira-Neto JL, McKerrow JH. PMID: 27227827; PMCID: PMC4881934.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    50. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. PMID: 26876147; PMCID: PMC5003402.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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    175. Characterization of immunoglobulin binding by schistosomes. Parasite Immunol. 2006 Sep; 28(9):407-19. McIntosh RS, Jones FM, Dunne DW, McKerrow JH, Pleass RJ. PMID: 16916364.
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    176. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. PMID: 16895475.
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    177. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794; PMCID: PMC1544199.
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    178. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des. 2006 May; 67(5):355-63. Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. PMID: 16784460.
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    179. Giardia lamblia cysteine proteases. Parasitol Res. 2006 Sep; 99(4):313-6. DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. PMID: 16598471.
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    180. Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. J Med Chem. 2006 Mar 23; 49(6):2096-102. Rapp M, Haubrich TA, Perrault J, Mackey ZB, McKerrow JH, Chiang PK, Wnuk SF. PMID: 16539398.
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    181. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. PMID: 16516467.
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    182. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. PMID: 18039124.
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    183. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. PMID: 16304193; PMCID: PMC1315979.
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    184. Designing drugs for parasitic diseases of the developing world. PLoS Med. 2005 Aug; 2(8):e210. McKerrow JH. PMID: 16120007; PMCID: PMC1196468.
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    185. Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics. 2005 Dec; 4(12):1862-75. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. PMID: 16112986.
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    186. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. PMID: 15950230.
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    187. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. PMID: 15964982; PMCID: PMC1166610.
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    188. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. PMID: 15899696.
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    189. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. PMID: 15862572.
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    190. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. PMID: 15582423.
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    191. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 01; 12(19):5203-11. Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. PMID: 15351403.
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    192. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004 Sep 15; 173(6):4020-9. Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA. PMID: 15356151.
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    193. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12; 279(46):48426-33. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. PMID: 15326171.
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    194. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug; 136(2):227-42. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. PMID: 15478801.
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    195. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. Debnath A, Das P, Sajid M, McKerrow JH. PMID: 15243916.
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    196. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. PMID: 15199048.
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    197. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
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    198. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. Caffrey CR, McKerrow JH, Salter JP, Sajid M. PMID: 15105025.
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    199. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 15055989.
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    200. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol. 2004 Mar-Apr; 106(3-4):158-63. Mahmoudzadeh-Niknam H, McKerrow JH. PMID: 15172223.
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    201. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Exp Parasitol. 2004 Jan-Feb; 106(1-2):59-61. Hernandez DC, Lim KC, McKerrow JH, Davies SJ. PMID: 15013791; PMCID: PMC2891232.
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    202. Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. Int J Parasitol. 2004 Jan; 34(1):27-36. Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH. PMID: 14711587; PMCID: PMC2859728.
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    203. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. PMID: 14719804.
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    204. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 14505663.
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    205. Developmental plasticity in schistosomes and other helminths. Int J Parasitol. 2003 Sep 30; 33(11):1277-84. Davies SJ, McKerrow JH. PMID: 13678642; PMCID: PMC2891239.
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    206. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. PMID: 12967713.
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    207. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. PMID: 12927956.
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    208. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. PMID: 12595442; PMCID: PMC148873.
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    209. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003; 6(4):272-80. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. PMID: 14663466.
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    210. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. PMID: 12061873.
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    211. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 03; 12(11):1537-41. Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. PMID: 12031337.
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    212. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 05; 277(27):24618-24. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. PMID: 11986325.
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    213. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
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    215. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. PMID: 11932146.
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    216. Cysteine proteases of parasitic organisms. Mol Biochem Parasitol. 2002 Mar; 120(1):1-21. Sajid M, McKerrow JH. PMID: 11849701.
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    217. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. PMID: 11755183.
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    218. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 09; 294(5545):1358-61. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. PMID: 11701932.
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    219. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. FEBS Lett. 2001 Nov 02; 507(3):362-6. Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G. PMID: 11696372.
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    220. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. PMID: 11704274.
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    221. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorg Med Chem Lett. 2001 Oct 22; 11(20):2759-62. Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. PMID: 11591518.
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    222. Identification, cloning, and recombinant expression of procalin, a major triatomine allergen. J Immunol. 2001 Sep 01; 167(5):2694-9. Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N. PMID: 11509613.
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    223. Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. J Biol Chem. 2000 Dec 08; 275(49):38667-73. Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. PMID: 10993899.
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    224. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. PMID: 10980453.
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    225. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15; 8(8):831-40. Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. PMID: 10997902.
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    228. A functional proteomics screen of proteases in colorectal carcinoma. Mol Med. 2000 May; 6(5):450-60. McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R. PMID: 10952024; PMCID: PMC1949953.
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    231. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. PMID: 10682836.
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    248. Simulium damnosum s.l.: isolation and identification of prophenoloxidase following an infection with Onchocerca spp. using targeted differential display. Exp Parasitol. 1997 Jul; 86(3):213-8. Hagen HE, Kläger SL, McKerrow JH, Ham PJ. PMID: 9225772.
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    249. A primitive enzyme for a primitive cell: the protease required for excystation of Giardia. Cell. 1997 May 02; 89(3):437-44. Ward W, Alvarado L, Rawlings ND, Engel JC, Franklin C, McKerrow JH. PMID: 9150143.
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    250. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb; 65(2):767-73. Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. PMID: 9009340; PMCID: PMC176123.
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    251. Cytokine induction and exploitation in schistosome infections. Parasitology. 1997; 115 Suppl:S107-12. McKerrow JH. PMID: 9571696.
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    252. Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation. J Immunol. 1997 Jan 01; 158(1):301-7. Leptak CL, McKerrow JH. PMID: 8977203.
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    253. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. J Biol Chem. 1996 Nov 22; 271(47):30181-9. Lustigman S, McKerrow JH, Shah K, Lui J, Huima T, Hough M, Brotman B. PMID: 8939969.
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    254. Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation. Infect Immun. 1996 Nov; 64(11):4706-13. Ritter DM, McKerrow JH. PMID: 8890229; PMCID: PMC174435.
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    255. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol Biochem Parasitol. 1996 Oct 30; 81(2):179-89. Wasilewski MM, Lim KC, Phillips J, McKerrow JH. PMID: 8898333.
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    256. Parasitic infections--molecular diagnosis and rational drug design. Biologicals. 1996 Sep; 24(3):207-8. McKerrow JH. PMID: 8978920.
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    257. Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep; 4(9):1421-7. Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. PMID: 8894100.
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    258. Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula. Exp Parasitol. 1996 Jun; 83(1):73-82. Ghendler Y, Parizade M, Arnon R, McKerrow JH, Fishelson Z. PMID: 8654554.
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    259. Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR. Exp Parasitol. 1995 Nov; 81(3):249-54. Hagen HE, Kläger SL, Chan V, Sakanari JA, McKerrow JH, Ham PJ. PMID: 7498421.
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    260. The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design. Parasitol Today. 1995 Aug; 11(8):279-82. McKerrow JH, McGrath ME, Engel JC. PMID: 15275323.
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    261. The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24; 247(2):251-9. McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. PMID: 7707373.
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    262. Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. Exp Parasitol. 1995 Feb; 80(1):1-7. Brindley PJ, Gam AA, McKerrow JH, Neva FA. PMID: 7529715.
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    263. Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol. 1994 Jun; 78(4):377-85. Mitro K, Bhagavathiammai A, Zhou OM, Bobbett G, McKerrow JH, Chokshi R, Chokshi B, James ER. PMID: 8206136.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    264. Naegleria fowleri: characterization of a secreted histolytic cysteine protease. Exp Parasitol. 1994 Mar; 78(2):230-41. Aldape K, Huizinga H, Bouvier J, McKerrow J. PMID: 8119377.
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    265. Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3583-7. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. PMID: 8475107; PMCID: PMC46345.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    266. Using scid mice to study parasitic diseases. Lab Anim Sci. 1993 Apr; 43(2):136-8. McKerrow JH, Ritter DM. PMID: 8320960.
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    267. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25; 268(9):6115-8. Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. PMID: 8454586.
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    268. Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Exp Parasitol. 1993 Mar; 76(2):127-33. Hong X, Bouvier J, Wong MM, Yamagata GY, McKerrow JH. PMID: 8454021.
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    269. Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Mol Biochem Parasitol. 1993 Mar; 58(1):17-24. Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH. PMID: 8459830.
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    270. The proteases and pathogenicity of parasitic protozoa. Annu Rev Microbiol. 1993; 47:821-53. McKerrow JH, Sun E, Rosenthal PJ, Bouvier J. PMID: 8257117.
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    271. Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38. Clawson GA, Norbeck LL, Hatem CL, Rhodes C, Amiri P, McKerrow JH, Patierno SR, Fiskum G. PMID: 1467310.
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    272. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992 Aug 25; 267(24):17339-46. Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH. PMID: 1512269.
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    273. Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae. Exp Parasitol. 1992 Aug; 75(1):87-98. Fishelson Z, Amiri P, Friend DS, Marikovsky M, Petitt M, Newport G, McKerrow JH. PMID: 1639166.
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    274. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. J Biol Chem. 1992 Apr 15; 267(11):7411-20. Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS. PMID: 1559982.
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    275. Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Mol Biochem Parasitol. 1992 Apr; 51(2):239-49. Ray C, McKerrow JH. PMID: 1574082.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    276. Pathogenesis in amebiasis: is it genetic or acquired? Infect Agents Dis. 1992 Feb; 1(1):11-4. McKerrow JH. PMID: 1365521.
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    277. Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man. Hum Pathol. 1992 Feb; 23(2):191-4. Jacques C, Richmond G, Tierney L, Curtis JL, McKerrow J, Warnock ML. PMID: 1740304.
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    278. A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence. Arch Med Res. 1992; 23(2):181-2. Reed S, Bouvier J, Hirata K, Que X, Pollack AS, Engel JC, Gillin F, McKerrow JH. PMID: 1340288.
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    279. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry. 1991 Nov 26; 30(47):11221-9. Cohen FE, Gregoret LM, Amiri P, Aldape K, Railey J, McKerrow JH. PMID: 1958659.
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    280. New insights into the structure of a Trypanosoma cruzi protease. Parasitol Today. 1991 Jun; 7(6):132-3. McKerrow JH. PMID: 15463468.
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    281. Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells. AIDS. 1991 Jan; 5(1):93-6. Brown M, Reed S, Levy JA, Busch M, McKerrow JH. PMID: 2059366.
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    282. The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli. J Biol Chem. 1990 Aug 15; 265(23):13528-32. Yuan L, Craig SP, McKerrow JH, Wang CC. PMID: 2199439.
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    283. Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990 Aug; 71(2):199-206. Keene WE, Hidalgo ME, Orozco E, McKerrow JH. PMID: 2373188.
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    284. Purification and amino-terminal sequence analysis of the complement-fixing and precipitin antigens from Coccidioides immitis. J Clin Microbiol. 1990 Feb; 28(2):385-8. Resnick S, Zimmer B, Pappagianis D, Eakin A, McKerrow J. PMID: 2312685; PMCID: PMC269617.
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    285. Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. Exp Parasitol. 1990 Feb; 70(2):134-43. McKerrow JH, Brindley P, Brown M, Gam AA, Staunton C, Neva FA. PMID: 2137091.
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    286. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Mol Biochem Parasitol. 1990 Feb; 39(1):1-8. Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH. PMID: 2406590.
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    287. [Direct relation between secretion of proteolytic enzymes and virulence in Entamoeba histolytica]. Arch Invest Med (Mex). 1990; 21 Suppl 1:133-8. Hidalgo ME, Hernández R, Keene WE, McKerrow JH, Orozco E. PMID: 2136478.
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    288. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989 Dec; 27(12):2772-7. Reed SL, Keene WE, McKerrow JH. PMID: 2556432; PMCID: PMC267124.
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    289. Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infect Immun. 1989 Oct; 57(10):3072-80. Apodaca G, McKerrow JH. PMID: 2674015; PMCID: PMC260772.
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    290. Regulation of Trichophyton rubrum proteolytic activity. Infect Immun. 1989 Oct; 57(10):3081-90. Apodaca G, McKerrow JH. PMID: 2476398; PMCID: PMC260773.
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    291. Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica. J Immunol. 1989 Jul 01; 143(1):189-95. Reed SL, Keene WE, McKerrow JH, Gigli I. PMID: 2543700.
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    292. Toxocara canis: proteolytic enzymes secreted by the infective larvae in vitro. Exp Parasitol. 1989 Jul; 69(1):30-6. Robertson BD, Bianco AT, McKerrow JH, Maizels RM. PMID: 2659374.
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    293. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4863-7. Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH. PMID: 2662185; PMCID: PMC297515.
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    294. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15; 35(2):177-83. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. PMID: 2671722.
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    295. Extracellular proteases of Onchocerca. Exp Parasitol. 1989 Feb; 68(2):176-85. Lackey A, James ER, Sakanari JA, Resnick SD, Brown M, Bianco AE, McKerrow JH. PMID: 2647506.
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    296. Parasite proteases. Exp Parasitol. 1989 Jan; 68(1):111-5. McKerrow JH. PMID: 2645160.
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    297. Schistosome proteases. Parasitol Today. 1988 Dec; 4(12):334-40. McKerrow JH, Doenhoff MJ. PMID: 15463025.
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    298. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov; 82(5):1560-6. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. PMID: 3053784; PMCID: PMC442723.
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    299. The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni. Mol Biochem Parasitol. 1988 Mar; 28(2):113-20. Amiri P, Sakanari J, Basch P, Newport G, McKerrow JH. PMID: 2452979.
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    300. Molecular cloning of Schistosoma mansoni myosin. Mol Biochem Parasitol. 1987 Nov; 26(1-2):29-38. Newport GR, Harrison RA, McKerrow J, Tarr P, Kallestad J, Agabian N. PMID: 3431565.
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    301. Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis. Infect Immun. 1987 Nov; 55(11):2807-15. Resnick S, Pappagianis D, McKerrow JH. PMID: 3312014; PMCID: PMC259981.
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    302. Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms. Exp Parasitol. 1986 Jun; 61(3):398-404. Lindquist RN, Senft AW, Petitt M, McKerrow J. PMID: 3519269.
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    303. The major neutral proteinase of Entamoeba histolytica. J Exp Med. 1986 Mar 01; 163(3):536-49. Keene WE, Petitt MG, Allen S, McKerrow JH. PMID: 2869098; PMCID: PMC2188059.
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    304. Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1985 Aug; 16(2):185-98. Dovey HF, McKerrow JH, Wang CC. PMID: 3929087.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    305. Isolation and characterization of a proteolytic enzyme from the adult hookworm Ancylostoma caninum. J Biol Chem. 1985 Jun 25; 260(12):7343-8. Hotez PJ, Trang NL, McKerrow JH, Cerami A. PMID: 3888998.
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    306. Schistosoma mansoni: degradation of host extracellular matrix by eggs and miracidia. Exp Parasitol. 1985 Apr; 59(2):217-21. Pino-Heiss S, Brown M, McKerrow JH. PMID: 3882446.
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    307. Purine salvage in Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1984 Apr; 11:157-67. Dovey HF, McKerrow JH, Wang CC. PMID: 6431283.
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    308. Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host. Lab Invest. 1983 Aug; 49(2):195-200. McKerrow JH, Keene WE, Jeong KH, Werb Z. PMID: 6876746.
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    309. Degradation of extracellular matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomula. Lab Invest. 1983 Aug; 49(2):201-7. Keene WE, Jeong KH, McKerrow JH, Werb Z. PMID: 6876747.
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    310. Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. Exp Parasitol. 1982 Apr; 53(2):249-54. McKerrow JH, Jeong KH. PMID: 7060706.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    311. Primary sequence dependence of the deamidation of rabbit muscle aldolase. Science. 1974 Jan 11; 183(4120):85. McKerrow JH, Robinson AB. PMID: 4808790.
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