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James Mckerrow

Title(s)Professor, School of Pharmacy and Pharmaceutical Science
SchoolHealth Sciences
Address9500 Gilman Drive #0657
La Jolla CA 92093
Phone858-822-7801
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    Collapse Research 
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    Novel antitrypanosomal alkaloids for Chagas disease
    NIH/NIAID R21AI128517Dec 7, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
    NIH/NCATS UH2TR001369Jul 15, 2015 - May 31, 2016
    Role: Principal Investigator
    Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease
    NIH/NIAID R01AI090605Jul 8, 2010 - Jun 30, 2015
    Role: Principal Investigator
    High Throughput Assay for Screening Compounds(RMI)
    NIH/NINDS R21NS053636Sep 30, 2005 - Aug 31, 2006
    Role: Principal Investigator
    Host Protein Degradation by Schistosome Parasites
    NIH/NIAID R01AI053247Jul 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    Proteases in Cancer Biology and Drug Development
    NIH/NCI P01CA072006Jun 1, 1998 - Nov 30, 2002
    Role: Co-Investigator
    SEROLOGIC MARKER OF EXPOSURE TO SCHISTOSOME PARASITES
    NIH/NIAID R03AI041466Sep 30, 1997 - Aug 31, 1999
    Role: Principal Investigator
    UCSF Liver Center
    NIH/NIDDK P30DK026743Dec 1, 1996 - Nov 30, 2000
    Role: Co-Investigator
    Predoctoral Training in Biomedical Sciences
    NIH/NIGMS T32GM008568Jul 1, 1995 - Mar 31, 2005
    Role: Principal Investigator
    Targeting Cysteine Proteases: Antiparasitic Chemotherapy
    NIH/NIAID P01AI035707May 1, 1995 - May 31, 2010
    Role: Principal Investigator
    CERCARIAL PROTEINASE OF SCHISTOSOMA MANSONI
    NIH/NIAID R01AI020452Jul 1, 1983 - Dec 31, 1989
    Role: Principal Investigator
    CHARACTERIZATION OF CERCARIAL PROTEINASE OF S MANSONI
    NIH/NIAID R22AI020452Jul 1, 1983 - Dec 31, 1989
    Role: Principal Investigator
    PROTEOLYTIC ACTIVITY OF THE LARVAE OF S. MANSONI
    NIH/NIAID R23AI020452Jul 1, 1983 - Jun 30, 1986
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. PLoS Negl Trop Dis. 2020 05; 14(5):e0007980. Wozniak JM, Silva TA, Thomas D, Siqueira-Neto JL, McKerrow JH, Gonzalez DJ, Calvet CM. PMID: 32433643.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The Antifungal Drug Isavuconazole Is both Amebicidal and Cysticidal against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2020 04 21; 64(5). Shing B, Singh S, Podust LM, McKerrow JH, Debnath A. PMID: 32094126.
      View in: PubMed   Mentions: 1     Fields:    
    3. High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for Trypanosoma cruzi. Microorganisms. 2020 Mar 26; 8(4). Bernatchez JA, Chen E, Hull MV, McNamara CW, McKerrow JH, Siqueira-Neto JL. PMID: 32224991.
      View in: PubMed   Mentions:
    4. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. J Med Chem. 2020 Mar 26; 63(6):3298-3316. Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. PMID: 32125159.
      View in: PubMed   Mentions:    Fields:    
    5. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):180-185. Carter DS, Jacobs RT, Freund YR, Berry PW, Akama T, Easom EE, Lunde CS, Rock F, Stefanakis R, McKerrow J, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Sakanari JA, Lustigman S, Plattner JJ. PMID: 31876143.
      View in: PubMed   Mentions:    Fields:    
    6. Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs. ACS Infect Dis. 2020 02 14; 6(2):173-179. Akama T, Freund YR, Berry PW, Carter DS, Easom EE, Jarnagin K, Lunde CS, Plattner JJ, Rock F, Stefanakis R, Fischer C, Bulman CA, Lim KC, Suzuki BM, Tricoche N, Mansour A, DiCosty U, McCall S, Carson B, McCall JW, McKerrow J, Hübner MP, Specht S, Hoerauf A, Lustigman S, Sakanari JA, Jacobs RT. PMID: 31876154.
      View in: PubMed   Mentions: 1     Fields:    
    7. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. ACS Med Chem Lett. 2020 Mar 12; 11(3):249-257. Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. PMID: 32184953.
      View in: PubMed   Mentions:
    8. Identification of Four Amoebicidal Nontoxic Compounds by a Molecular Docking Screen of Naegleria fowleri Sterol ?8-?7-Isomerase and Phenotypic Assays. ACS Infect Dis. 2019 12 13; 5(12):2029-2038. Shi D, Chahal KK, Oto P, Nothias LF, Debnath A, McKerrow JH, Podust LM, Abagyan R. PMID: 31583882.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms. PLoS Negl Trop Dis. 2018 10; 12(10):e0006923. Rebello KM, McKerrow JH, Mota EM, O'Donoghue AJ, Neves-Ferreira AGC. PMID: 30379807.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data. Sci Rep. 2018 08 30; 8(1):13092. White Bear J, Long T, Skinner D, McKerrow JH. PMID: 30166569.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Update on drug development targeting parasite cysteine proteases. PLoS Negl Trop Dis. 2018 08; 12(8):e0005850. McKerrow JH. PMID: 30138309.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. The diverse roles of cysteine proteases in parasites and their suitability as drug targets. PLoS Negl Trop Dis. 2018 08; 12(8):e0005639. McKerrow JH. PMID: 30138311.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Why Funding for Neglected Tropical Diseases Should Be a Global Priority. Clin Infect Dis. 2018 07 18; 67(3):323-326. Reed SL, McKerrow JH. PMID: 29688342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    14. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L. Front Mol Biosci. 2018; 5:40. Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. PMID: 29725596.
      View in: PubMed   Mentions:
    15. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. PMID: 29565998.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Exp Parasitol. 2018 May; 188:36-41. Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. PMID: 29551628.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri. Front Microbiol. 2018; 9:414. Debnath A, Nelson AT, Silva-Olivares A, Shibayama M, Siegel D, McKerrow JH. PMID: 29559968.
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    18. CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis. 2017 12; 11(12):e0006104. Debnath A, Calvet CM, Jennings G, Zhou W, Aksenov A, Luth MR, Abagyan R, Nes WD, McKerrow JH, Podust LM. PMID: 29284029.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2017 12; 11(12):e0006132. Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. PMID: 29281643.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    20. Mass Spectrometry-Based Chemical Cartography of a Cardiac Parasitic Infection. Anal Chem. 2017 10 03; 89(19):10414-10421. McCall LI, Morton JT, Bernatchez JA, de Siqueira-Neto JL, Knight R, Dorrestein PC, McKerrow JH. PMID: 28892370.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005680. Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. PMID: 28704396.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. The rule of five should not impede anti-parasitic drug development. Int J Parasitol Drugs Drug Resist. 2017 08; 7(2):248-249. McKerrow JH, Lipinski CA. PMID: 28623818.
      View in: PubMed   Mentions: 2     Fields:    
    23. Editorial: Drug Development for Parasite-Induced Diarrheal Diseases. Front Microbiol. 2017; 8:577. Debnath A, McKerrow JH. PMID: 28421063.
      View in: PubMed   Mentions:
    24. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 12; 10(12):e0005234. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. PMID: 28036391.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. PMID: 27821451.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    26. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 02 17; 12(2):422-434. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler EA. PMID: 27977118.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    27. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. PLoS Negl Trop Dis. 2016 08; 10(8):e0004893. Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. PMID: 27501047.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis. PLoS Pathog. 2016 05; 12(5):e1005519. McCall LI, Siqueira-Neto JL, McKerrow JH. PMID: 27227827.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    29. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. PMID: 26876147.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0004356. Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. PMID: 26751972.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. PMID: 26819670.
      View in: PubMed   Mentions:
    32. Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrob Agents Chemother. 2015 Dec; 59(12):7923-4. Urbina JA, McKerrow JH. PMID: 26578701.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    33. Recognition of the role of Natural Products as drugs to treat neglected tropical diseases by the 2015 Nobel prize in physiology or medicine. Nat Prod Rep. 2015 Dec 19; 32(12):1610-1. McKerrow JH. PMID: 26510605.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    34. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. ACS Chem Biol. 2015 Oct 16; 10(10):2373-81. Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. PMID: 26270237.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    35. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog. 2015 Jul; 11(7):e1005058. Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. PMID: 26186534.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    36. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. PLoS Negl Trop Dis. 2015; 9(7):e0003916. Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. PMID: 26173110.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    38. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015; 9(6):e0003827. Fajtová P, Štefanic S, Hradilek M, Dvorák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. PMID: 26039195.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Front Microbiol. 2015; 6:368. Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. PMID: 26029171.
      View in: PubMed   Mentions:
    40. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. PLoS Negl Trop Dis. 2015 Mar; 9(3):e0003588. McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. PMID: 25768284.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    41. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother. 2015 May; 59(5):2666-77. Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS. PMID: 25712353.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    43. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr; 116:76-84. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. PMID: 25666761.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    44. Current and Future Chemotherapy for Chagas Disease. Curr Med Chem. 2015; 22(37):4293-312. Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. PMID: 26477622.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    45. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. J Med Chem. 2014 Dec 11; 57(23):10162-75. Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. PMID: 25393646.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure. 2014 Dec 02; 22(12):1786-1798. Jílková A, Horn M, Rezácová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. PMID: 25456815.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    47. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. J Med Chem. 2014 Aug 28; 57(16):6989-7005. Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. PMID: 25101801.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    49. Determinants of disease phenotype in trypanosomatid parasites. Trends Parasitol. 2014 Jul; 30(7):342-9. McCall LI, McKerrow JH. PMID: 24946952.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    50. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. PMID: 24820073.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    51. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. PLoS Negl Trop Dis. 2014 Mar; 8(3):e2766. Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvorák J. PMID: 24676141.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    52. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. ACS Med Chem Lett. 2014 Apr 10; 5(4):434-9. Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. PMID: 24900854.
      View in: PubMed   Mentions:
    53. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. ACS Med Chem Lett. 2014 Feb 13; 5(2):149-53. Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. PMID: 24900788.
      View in: PubMed   Mentions:
    54. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrob Agents Chemother. 2014; 58(3):1523-8. Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. PMID: 24366747.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    55. TLTF in cerebrospinal fluid for detection and staging of T. b. gambiense infection. PLoS One. 2013; 8(11):e79281. Abdulla MH, Bakhiet M, Lejon V, Andersson J, McKerrow J, Al-Obeed O, Harris RA. PMID: 24260185.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCTClinical Trials
    56. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. J Med Chem. 2013 Oct 10; 56(19):7651-68. Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. PMID: 24079662.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    57. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. PMID: 24060869.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    58. Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. PLoS Negl Trop Dis. 2013; 7(8):e2370. Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. PMID: 23991231.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    59. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica. PLoS Negl Trop Dis. 2013; 7(7):e2269. Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. PMID: 23875031.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    60. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. PMID: 23853713.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    61. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. J Nat Prod. 2013 Apr 26; 76(4):630-41. Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. PMID: 23445522.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    62. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. PMID: 23403423.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    63. Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis. Curr Med Chem. 2013; 20(25):3078-102. Rascón AA, McKerrow JH. PMID: 23514418.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    64. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 2012 Dec 18; 51(50):10087-98. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. PMID: 23181936.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    65. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. PLoS Negl Trop Dis. 2012; 6(12):e1942. Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. PMID: 23236535.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    66. Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods. 2012 Nov; 9(11):1095-100. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. PMID: 23023596.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    67. Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. PLoS One. 2012; 7(9):e46172. Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG. PMID: 23029428.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    68. Early invasion of brain parenchyma by African trypanosomes. PLoS One. 2012; 7(8):e43913. Frevert U, Movila A, Nikolskaia OV, Raper J, Mackey ZB, Abdulla M, McKerrow J, Grab DJ. PMID: 22952808.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    69. Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice. Bioorg Med Chem. 2012 Nov 01; 20(21):6423-33. dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB. PMID: 23006639.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    70. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog. 2012; 8(8):e1002883. Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. PMID: 22927819.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    71. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6256-60. Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. PMID: 22926067.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    72. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012 Nov; 56(11):5450-7. Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. PMID: 22869574.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    73. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. PMID: 22860142.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    74. Ask the experts. Future Med Chem. 2012 Jul; 4(11):1383-9. Pecoul B, Pollastri M, McKerrow J, Bueno-Calderon JM. PMID: 22857528.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    75. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. PMID: 22610278.
      View in: PubMed   Mentions: 87     Fields:    Translation:Animals
    76. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem. 2012 Jun 15; 287(25):21152-63. Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. PMID: 22539347.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    77. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(4):e1589. Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. PMID: 22509414.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    78. WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites. PLoS Negl Trop Dis. 2012 Jan; 6(1):e1494. Marcellino C, Gut J, Lim KC, Singh R, McKerrow J, Sakanari J. PMID: 22303493.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    79. A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem. 2012 03 02; 287(10):7074-83. Lopez Quezada L, Sajid M, Lim KC, McKerrow JH. PMID: 22174417.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    80. Leishmania major protein disulfide isomerase as a drug target: enzymatic and functional characterization. Parasitol Res. 2012 May; 110(5):1911-7. Ben Khalaf N, De Muylder G, Louzir H, McKerrow J, Chenik M. PMID: 22160278.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    81. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368. Abdulla MH, Lim KC, McKerrow JH, Caffrey CR. PMID: 22039561.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    82. Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. PLoS Negl Trop Dis. 2011 Sep; 5(9):e1337. Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, McKerrow J. PMID: 21980548.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    83. The Trypanosoma cruzi protease cruzain mediates immune evasion. PLoS Pathog. 2011 Sep; 7(9):e1002139. Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. PMID: 21909255.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    84. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. J Biol Chem. 2011 Oct 14; 286(41):35770-81. Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M. PMID: 21832058.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    85. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Res. 2011 Nov; 92(2):187-94. Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. PMID: 21820471.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    86. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. Int J Parasitol. 2011 Oct; 41(12):1253-62. Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. PMID: 21819989.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    87. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul; 5(7):e1253. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. PMID: 21811648.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    88. High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei. Chem Biol Drug Des. 2011 Sep; 78(3):454-63. Mackey ZB, Koupparis K, Nishino M, McKerrow JH. PMID: 21668652.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    89. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    90. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. J Biomol Screen. 2011 Jun; 16(5):545-51. Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. PMID: 21441416.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    91. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. PMID: 21262276.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    92. Cruzain : the path from target validation to the clinic. Adv Exp Med Biol. 2011; 712:100-15. Sajid M, Robertson SA, Brinen LS, McKerrow JH. PMID: 21660661.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    93. IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Sci Transl Med. 2010 Dec 01; 2(60):60ra88. Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P. PMID: 21123809.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    94. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem. 2011 Jan 07; 286(1):429-40. Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. PMID: 20961853.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    95. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis. 2010 Oct 19; 4(10):e850. Stefanic S, Dvorák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR. PMID: 20976050.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    96. Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem. 2010 Nov 15; 18(22):7826-35. Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH. PMID: 20961766.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    97. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. PLoS Negl Trop Dis. 2010 Sep 14; 4(9). Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. PMID: 20856868.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    98. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. J Biol Chem. 2010 Oct 08; 285(41):31120-9. Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH. PMID: 20675366.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    99. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 08; 53(13):4891-905. Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. PMID: 20540517.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    100. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Aug; 54(8):3326-34. Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. PMID: 20547819.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    101. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother. 2010 Jun; 54(6):2480-8. Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. PMID: 20385875.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    102. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11; 285(24):18516-27. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. PMID: 20378535.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    103. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis. 2010 Apr 06; 4(4):e651. Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. PMID: 20386598.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    104. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis. 2010 Mar 30; 4(3):e648. Zhang S, Kim CC, Batra S, McKerrow JH, Loke P. PMID: 20361029.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    105. Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorg Med Chem. 2010 Apr 01; 18(7):2566-74. Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P. PMID: 20303767.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    106. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. J Med Chem. 2010 Feb 25; 53(4):1763-73. Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. PMID: 20088534.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    107. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14; 53(1):52-60. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. PMID: 19908842.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    108. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). J Med Chem. 2009 Nov 26; 52(22):7192-210. Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. PMID: 19848405.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    109. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Mol Biochem Parasitol. 2010 Mar; 170(1):37-40. Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR. PMID: 19914302.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    110. Structure-guided development of selective TbcatB inhibitors. J Med Chem. 2009 Oct 22; 52(20):6489-93. Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. PMID: 19769357.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    111. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell. 2009 Nov; 8(11):1665-76. Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH. PMID: 19749174.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    112. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. PMID: 19773167.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    113. Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27; 52(16):5005-8. Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. PMID: 19637873.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    114. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703. Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. PMID: 19620707.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    115. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. PMID: 19597541.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    116. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31. Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, Rosenthal PJ, Chiang PK. PMID: 19648008.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    117. Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz. 2009 Jul; 104 Suppl 1:263-9. McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. PMID: 19753483.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    118. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2009 Jun 02; 3(6):e449. Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. PMID: 19488406.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    119. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg. 2009 Mar; 80(3):416-24. Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, Beatty PR, Harris E. PMID: 19270292.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    120. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One. 2009; 4(2):e4413. Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. PMID: 19198654.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    121. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis. 2009; 3(2):e372. Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. PMID: 19190730.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    122. Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec; 21(6):668-72. McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. PMID: 18978536.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    123. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis. 2008 Sep 24; 2(9):e298. Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. PMID: 18820745.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    124. A parasite cysteine protease is key to host protein degradation and iron acquisition. J Biol Chem. 2008 Oct 24; 283(43):28934-43. O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. PMID: 18701454.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    125. Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e262. Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. PMID: 18629379.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    126. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):5860-3. Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. PMID: 18585034.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    127. Metal compounds for the treatment of parasitic diseases. J Inorg Biochem. 2008 Oct; 102(10):1839-45. Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH. PMID: 18684510.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    128. Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Mol Biochem Parasitol. 2008 Aug; 160(2):129-37. Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH. PMID: 18554733.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    129. Identification of the major cysteine protease of Giardia and its role in encystation. J Biol Chem. 2008 Jun 27; 283(26):18024-31. DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. PMID: 18445589.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    130. Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc. 2008 May 21; 130(20):6404-10. Brak K, Doyle PS, McKerrow JH, Ellman JA. PMID: 18435536.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    131. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 08; 51(9):2816-32. Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. PMID: 18416543.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    132. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 01; 18(9):2883-5. Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. PMID: 18420405.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    133. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14; 51(3):545-52. Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. PMID: 18173229.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    134. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem. 2008 Apr 11; 283(15):9896-908. Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. PMID: 18160404.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    135. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):624-8. Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. PMID: 18055204.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    136. Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6697-700. González FV, Izquierdo J, Rodríguez S, McKerrow JH, Hansell E. PMID: 17977725.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    137. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. PMID: 17936488.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    138. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov; 51(11):3932-9. Doyle PS, Zhou YM, Engel JC, McKerrow JH. PMID: 17698625.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    139. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. FEBS Lett. 2007 Sep 04; 581(22):4260-4. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K. PMID: 17707374.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    140. Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions. Mol Immunol. 2008 Jan; 45(2):567-74. Aslam A, Quinn P, McIntosh RS, Shi J, Ghumra A, McKerrow JH, Bunting KA, Dunne DW, Doenhoff MJ, Morrison SL, Zhang K, Pleass RJ. PMID: 17631966.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    141. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 2007 Jul 31; 46(30):8744-52. Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. PMID: 17605471.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    142. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. PMID: 17513563.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    143. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43. Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. PMID: 17502099.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    144. Proteomic analysis of adult S. mansoni gut contents. Mol Biochem Parasitol. 2007 Jul; 154(1):95-7. Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH. PMID: 17451823.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    145. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrob Agents Chemother. 2007 Jun; 51(6):2164-72. Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. PMID: 17371810.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    146. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. Int J Parasitol. 2007 Jul; 37(8-9):897-906. Debnath A, Tashker JS, Sajid M, McKerrow JH. PMID: 17362964.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    147. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. Int J Parasitol. 2007 Jun; 37(7):713-24. Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. PMID: 17336985.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    148. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med. 2007 Jan; 4(1):e14. Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. PMID: 17214506.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    149. Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol. 2007; 8(4):R65. Jolly ER, Chin CS, Miller S, Bahgat MM, Lim KC, DeRisi J, McKerrow JH. PMID: 17456242.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    150. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006 Dec; 2(12):701-10. Renslo AR, McKerrow JH. PMID: 17108988.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    151. The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 01; 194(11):1609-16. Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ. PMID: 17083048.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    152. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem. 2006 Dec 22; 281(51):39316-29. Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. PMID: 17028179.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    153. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. PMID: 16987516.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    154. Characterization of immunoglobulin binding by schistosomes. Parasite Immunol. 2006 Sep; 28(9):407-19. McIntosh RS, Jones FM, Dunne DW, McKerrow JH, Pleass RJ. PMID: 16916364.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    155. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem. 2006 Aug; 387(8):1053-61. Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. PMID: 16895475.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    156. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8. Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. PMID: 16864794.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    157. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des. 2006 May; 67(5):355-63. Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. PMID: 16784460.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    158. Giardia lamblia cysteine proteases. Parasitol Res. 2006 Sep; 99(4):313-6. DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. PMID: 16598471.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    159. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett. 2006 May 15; 16(10):2753-7. Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. PMID: 16516467.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    160. Proteases in parasitic diseases. Annu Rev Pathol. 2006; 1:497-536. McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. PMID: 18039124.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimals
    161. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. PMID: 16304193.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    162. Designing drugs for parasitic diseases of the developing world. PLoS Med. 2005 Aug; 2(8):e210. McKerrow JH. PMID: 16120007.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    163. Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics. 2005 Dec; 4(12):1862-75. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. PMID: 16112986.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    164. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition. Int J Parasitol. 2005 Jul; 35(8):895-910. Dvorák J, Delcroix M, Rossi A, Vopálenský V, Pospísek M, Sedinová M, Mikes L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. PMID: 15950230.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    165. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43. Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. PMID: 15964982.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    166. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors. Biol Chem. 2005 Apr; 386(4):339-49. Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondrásek J. PMID: 15899696.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    167. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. Int J Parasitol. 2005 May; 35(6):583-9. Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. PMID: 15862572.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    168. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3. Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. PMID: 15582423.
      View in: PubMed   Mentions: 15     Fields:    
    169. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorg Med Chem. 2004 Oct 01; 12(19):5203-11. Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. PMID: 15351403.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    170. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004 Sep 15; 173(6):4020-9. Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA. PMID: 15356151.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    171. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem. 2004 Nov 12; 279(46):48426-33. Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. PMID: 15326171.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    172. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004 Aug; 136(2):227-42. Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. PMID: 15478801.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    173. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica. J Infect Dis. 2004 Aug 01; 190(3):448-57. Debnath A, Das P, Sajid M, McKerrow JH. PMID: 15243916.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    174. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7. Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. PMID: 15199048.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    175. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9. Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 15163200.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    176. Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol. 2004 May; 20(5):241-8. Caffrey CR, McKerrow JH, Salter JP, Sajid M. PMID: 15105025.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    177. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 08; 47(8):1889-92. Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. PMID: 15055989.
      View in: PubMed   Mentions: 16     Fields:    
    178. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol. 2004 Mar-Apr; 106(3-4):158-63. Mahmoudzadeh-Niknam H, McKerrow JH. PMID: 15172223.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    179. Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. Int J Parasitol. 2004 Jan; 34(1):27-36. Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH. PMID: 14711587.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    180. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Exp Parasitol. 2004 Jan-Feb; 106(1-2):59-61. Hernandez DC, Lim KC, McKerrow JH, Davies SJ. PMID: 15013791.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    181. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biol Chem. 2003 Dec; 384(12):1613-8. James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. PMID: 14719804.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    182. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30. Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. PMID: 14505663.
      View in: PubMed   Mentions: 16     Fields:    
    183. Developmental plasticity in schistosomes and other helminths. Int J Parasitol. 2003 Sep 30; 33(11):1277-84. Davies SJ, McKerrow JH. PMID: 13678642.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    184. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol. 2003 Sep; 131(1):65-75. Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. PMID: 12967713.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    185. Improved trypanocidal activities of cathepsin L inhibitors. Int J Antimicrob Agents. 2003 Aug; 22(2):155-9. Nkemgu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. PMID: 12927956.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    186. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. PMID: 12595442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    187. Patterns of protease production during prostate cancer progression: proteomic evidence for cascades in a transgenic model. Prostate Cancer Prostatic Dis. 2003; 6(4):272-80. Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. PMID: 14663466.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    188. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. J Med Chem. 2002 Jun 20; 45(13):2695-707. Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. PMID: 12061873.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    189. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorg Med Chem Lett. 2002 Jun 03; 12(11):1537-41. Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. PMID: 12031337.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    190. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem. 2002 Jul 05; 277(27):24618-24. Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. PMID: 11986325.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    191. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries. Mol Biochem Parasitol. 2002 Apr 30; 121(1):99-105. Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. PMID: 11985866.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    192. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Mol Biochem Parasitol. 2002 Apr 30; 121(1):49-61. Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. PMID: 11985862.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    193. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. Int J Antimicrob Agents. 2002 Mar; 19(3):227-31. Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. PMID: 11932146.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    194. Cysteine proteases of parasitic organisms. Mol Biochem Parasitol. 2002 Mar; 120(1):1-21. Sajid M, McKerrow JH. PMID: 11849701.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    195. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. PMID: 11755183.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    196. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science. 2001 Nov 09; 294(5545):1358-61. Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. PMID: 11701932.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    197. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. FEBS Lett. 2001 Nov 02; 507(3):362-6. Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G. PMID: 11696372.
      View in: PubMed   Mentions:    Fields:    
    198. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol. 2001 Nov; 118(1):61-73. Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. PMID: 11704274.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    199. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorg Med Chem Lett. 2001 Oct 22; 11(20):2759-62. Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. PMID: 11591518.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    200. Identification, cloning, and recombinant expression of procalin, a major triatomine allergen. J Immunol. 2001 Sep 01; 167(5):2694-9. Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N. PMID: 11509613.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    201. Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. J Biol Chem. 2000 Dec 08; 275(49):38667-73. Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. PMID: 10993899.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    202. Aryl ureas represent a new class of anti-trypanosomal agents. Chem Biol. 2000 Sep; 7(9):733-42. Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. PMID: 10980453.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    203. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15; 8(8):831-40. Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. PMID: 10997902.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    204. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Mol Med. 2000 Aug; 6(8):660-9. Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE. PMID: 11055585.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    205. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Arch Med Res. 2000 Jul-Aug; 31(4 Suppl):S63-4. Brinen LS, Que X, McKerrow JH, Reed SL. PMID: 11070225.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    206. A functional proteomics screen of proteases in colorectal carcinoma. Mol Med. 2000 May; 6(5):450-60. McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R. PMID: 10952024.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    207. Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi. J Cell Sci. 2000 Apr; 113 ( Pt 8):1345-54. Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH, Garcia CT. PMID: 10725218.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    208. The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain. FEBS Lett. 2000 Mar 03; 469(1):29-32. Stoka V, Turk B, McKerrow JH, Björk I, Cazzulo JJ, Turk V. PMID: 10708750.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    209. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Lett. 2000 Jan 28; 466(2-3):244-8. Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. PMID: 10682836.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    210. A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis. J Neurogenet. 1999 Nov; 13(3):157-80. Loer CM, Davidson B, Mckerrow J. PMID: 10928216.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    211. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Mol Biochem Parasitol. 1999 Oct 15; 103(2):171-81. Britton C, Redmond DL, Knox DP, McKerrow JH, Barry JD. PMID: 10551361.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    212. Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11015-22. Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, McKerrow JH. PMID: 10500116.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    213. Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif. J Biol Chem. 1999 Jun 04; 274(23):16249-56. Huete-Pérez JA, Engel JC, Brinen LS, Mottram JC, McKerrow JH. PMID: 10347181.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    214. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. Int J Parasitol. 1999 Jun; 29(6):833-7. McKerrow JH. PMID: 10480720.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    215. Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. Biochem J. 1999 May 15; 340 ( Pt 1):113-7. Chan VJ, Selzer PM, McKerrow JH, Sakanari JA. PMID: 10229665.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    216. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei. Exp Parasitol. 1999 Apr; 91(4):349-55. Troeberg L, Morty RE, Pike RN, Lonsdale-Eccles JD, Palmer JT, McKerrow JH, Coetzer TH. PMID: 10092479.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    217. Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg Med Chem. 1999 Apr; 7(4):639-44. McKerrow JH, Engel JC, Caffrey CR. PMID: 10353643.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    218. [Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental Chagas disease]. Medicina (B Aires). 1999; 59 Suppl 2:171-5. Engel JC, Doyle PS, McKerrow JH. PMID: 10668260.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    219. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors. Bioorg Med Chem. 1998 Dec; 6(12):2477-94. Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ. PMID: 9925304.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    220. Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain. Bioorg Med Chem Lett. 1998 Oct 06; 8(19):2809-12. Roush WR, González FV, McKerrow JH, Hansell E. PMID: 9873627.
      View in: PubMed   Mentions: 1     Fields:    
    221. Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection. J Exp Med. 1998 Aug 17; 188(4):725-34. Engel JC, Doyle PS, Hsieh I, McKerrow JH. PMID: 9705954.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    222. Substrate inhibition of cruzipain is not affected by the C-terminal domain. FEBS Lett. 1998 Jun 12; 429(2):129-33. Stoka V, McKerrow JH, Cazzulo JJ, Turk V. PMID: 9650575.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    223. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi. J Cell Sci. 1998 Mar; 111 ( Pt 5):597-606. Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF, McKerrow JH. PMID: 9454733.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    224. Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. J Mol Biol. 1998; 283(1):15-27. Britton C, McKerrow JH, Johnstone IL. PMID: 9761670.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    225. Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp Parasitol. 1997 Nov; 87(3):212-21. Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH. PMID: 9371086.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    226. Simulium damnosum s.l.: isolation and identification of prophenoloxidase following an infection with Onchocerca spp. using targeted differential display. Exp Parasitol. 1997 Jul; 86(3):213-8. Hagen HE, Kläger SL, McKerrow JH, Ham PJ. PMID: 9225772.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    227. A primitive enzyme for a primitive cell: the protease required for excystation of Giardia. Cell. 1997 May 02; 89(3):437-44. Ward W, Alvarado L, Rawlings ND, Engel JC, Franklin C, McKerrow JH. PMID: 9150143.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    228. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb; 65(2):767-73. Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. PMID: 9009340.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    229. Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation. J Immunol. 1997 Jan 01; 158(1):301-7. Leptak CL, McKerrow JH. PMID: 8977203.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsPHPublic Health
    230. Cytokine induction and exploitation in schistosome infections. Parasitology. 1997; 115 Suppl:S107-12. McKerrow JH. PMID: 9571696.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    231. Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae. J Biol Chem. 1996 Nov 22; 271(47):30181-9. Lustigman S, McKerrow JH, Shah K, Lui J, Huima T, Hough M, Brotman B. PMID: 8939969.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    232. Intercellular adhesion molecule 1 is the major adhesion molecule expressed during schistosome granuloma formation. Infect Immun. 1996 Nov; 64(11):4706-13. Ritter DM, McKerrow JH. PMID: 8890229.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    233. Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo. Mol Biochem Parasitol. 1996 Oct 30; 81(2):179-89. Wasilewski MM, Lim KC, Phillips J, McKerrow JH. PMID: 8898333.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    234. Structure-based design of parasitic protease inhibitors. Bioorg Med Chem. 1996 Sep; 4(9):1421-7. Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, Kenyon GL. PMID: 8894100.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    235. Parasitic infections--molecular diagnosis and rational drug design. Biologicals. 1996 Sep; 24(3):207-8. McKerrow JH. PMID: 8978920.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    236. Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula. Exp Parasitol. 1996 Jun; 83(1):73-82. Ghendler Y, Parizade M, Arnon R, McKerrow JH, Fishelson Z. PMID: 8654554.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    237. Simulium damnosum s.l.: identification of inducible serine proteases following an Onchocerca infection by differential display reverse transcription PCR. Exp Parasitol. 1995 Nov; 81(3):249-54. Hagen HE, Kläger SL, Chan V, Sakanari JA, McKerrow JH, Ham PJ. PMID: 7498421.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    238. The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design. Parasitol Today. 1995 Aug; 11(8):279-82. McKerrow JH, McGrath ME, Engel JC. PMID: 15275323.
      View in: PubMed   Mentions: 13     Fields:    
    239. The crystal structure of cruzain: a therapeutic target for Chagas' disease. J Mol Biol. 1995 Mar 24; 247(2):251-9. McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. PMID: 7707373.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    240. Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis. Exp Parasitol. 1995 Feb; 80(1):1-7. Brindley PJ, Gam AA, McKerrow JH, Neva FA. PMID: 7529715.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    241. Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol. 1994 Jun; 78(4):377-85. Mitro K, Bhagavathiammai A, Zhou OM, Bobbett G, McKerrow JH, Chokshi R, Chokshi B, James ER. PMID: 8206136.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    242. Naegleria fowleri: characterization of a secreted histolytic cysteine protease. Exp Parasitol. 1994 Mar; 78(2):230-41. Aldape K, Huizinga H, Bouvier J, McKerrow J. PMID: 8119377.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    243. Structure-based inhibitor design by using protein models for the development of antiparasitic agents. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3583-7. Ring CS, Sun E, McKerrow JH, Lee GK, Rosenthal PJ, Kuntz ID, Cohen FE. PMID: 8475107.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    244. Using scid mice to study parasitic diseases. Lab Anim Sci. 1993 Apr; 43(2):136-8. McKerrow JH, Ritter DM. PMID: 8320960.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    245. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi. J Biol Chem. 1993 Mar 25; 268(9):6115-8. Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS. PMID: 8454586.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    246. Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi. Mol Biochem Parasitol. 1993 Mar; 58(1):17-24. Harth G, Andrews N, Mills AA, Engel JC, Smith R, McKerrow JH. PMID: 8459830.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    247. Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Exp Parasitol. 1993 Mar; 76(2):127-33. Hong X, Bouvier J, Wong MM, Yamagata GY, McKerrow JH. PMID: 8454021.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    248. The proteases and pathogenicity of parasitic protozoa. Annu Rev Microbiol. 1993; 47:821-53. McKerrow JH, Sun E, Rosenthal PJ, Bouvier J. PMID: 8257117.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    249. Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38. Clawson GA, Norbeck LL, Hatem CL, Rhodes C, Amiri P, McKerrow JH, Patierno SR, Fiskum G. PMID: 1467310.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    250. Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus. J Biol Chem. 1992 Aug 25; 267(24):17339-46. Lustigman S, Brotman B, Huima T, Prince AM, McKerrow JH. PMID: 1512269.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    251. Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae. Exp Parasitol. 1992 Aug; 75(1):87-98. Fishelson Z, Amiri P, Friend DS, Marikovsky M, Petitt M, Newport G, McKerrow JH. PMID: 1639166.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    252. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi. J Biol Chem. 1992 Apr 15; 267(11):7411-20. Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS. PMID: 1559982.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    253. Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene. Mol Biochem Parasitol. 1992 Apr; 51(2):239-49. Ray C, McKerrow JH. PMID: 1574082.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    254. Pathogenesis in amebiasis: is it genetic or acquired? Infect Agents Dis. 1992 Feb; 1(1):11-4. McKerrow JH. PMID: 1365521.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    255. Primary pulmonary hypertension and human immunodeficiency virus infection in a non-hemophiliac man. Hum Pathol. 1992 Feb; 23(2):191-4. Jacques C, Richmond G, Tierney L, Curtis JL, McKerrow J, Warnock ML. PMID: 1740304.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    256. A unique cysteine proteinase gene of pathogenic Entamoeba histolytica correlates with virulence. Arch Med Res. 1992; 23(2):181-2. Reed S, Bouvier J, Hirata K, Que X, Pollack AS, Engel JC, Gillin F, McKerrow JH. PMID: 1340288.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    257. Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling. Biochemistry. 1991 Nov 26; 30(47):11221-9. Cohen FE, Gregoret LM, Amiri P, Aldape K, Railey J, McKerrow JH. PMID: 1958659.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    258. New insights into the structure of a Trypanosoma cruzi protease. Parasitol Today. 1991 Jun; 7(6):132-3. McKerrow JH. PMID: 15463468.
      View in: PubMed   Mentions:    Fields:    
    259. Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells. AIDS. 1991 Jan; 5(1):93-6. Brown M, Reed S, Levy JA, Busch M, McKerrow JH. PMID: 2059366.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    260. The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli. J Biol Chem. 1990 Aug 15; 265(23):13528-32. Yuan L, Craig SP, McKerrow JH, Wang CC. PMID: 2199439.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    261. Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase. Exp Parasitol. 1990 Aug; 71(2):199-206. Keene WE, Hidalgo ME, Orozco E, McKerrow JH. PMID: 2373188.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    262. Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae. Exp Parasitol. 1990 Feb; 70(2):134-43. McKerrow JH, Brindley P, Brown M, Gam AA, Staunton C, Neva FA. PMID: 2137091.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    263. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Mol Biochem Parasitol. 1990 Feb; 39(1):1-8. Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH. PMID: 2406590.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    264. Purification and amino-terminal sequence analysis of the complement-fixing and precipitin antigens from Coccidioides immitis. J Clin Microbiol. 1990 Feb; 28(2):385-8. Resnick S, Zimmer B, Pappagianis D, Eakin A, McKerrow J. PMID: 2312685.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    265. [Direct relation between secretion of proteolytic enzymes and virulence in Entamoeba histolytica]. Arch Invest Med (Mex). 1990; 21 Suppl 1:133-8. Hidalgo ME, Hernández R, Keene WE, McKerrow JH, Orozco E. PMID: 2136478.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    266. Thiol proteinase expression and pathogenicity of Entamoeba histolytica. J Clin Microbiol. 1989 Dec; 27(12):2772-7. Reed SL, Keene WE, McKerrow JH. PMID: 2556432.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    267. Regulation of Trichophyton rubrum proteolytic activity. Infect Immun. 1989 Oct; 57(10):3081-90. Apodaca G, McKerrow JH. PMID: 2476398.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    268. Purification and characterization of a 27,000-Mr extracellular proteinase from Trichophyton rubrum. Infect Immun. 1989 Oct; 57(10):3072-80. Apodaca G, McKerrow JH. PMID: 2674015.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    269. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4863-7. Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH. PMID: 2662185.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    270. Toxocara canis: proteolytic enzymes secreted by the infective larvae in vitro. Exp Parasitol. 1989 Jul; 69(1):30-6. Robertson BD, Bianco AT, McKerrow JH, Maizels RM. PMID: 2659374.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    271. Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica. J Immunol. 1989 Jul 01; 143(1):189-95. Reed SL, Keene WE, McKerrow JH, Gigli I. PMID: 2543700.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    272. Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15; 35(2):177-83. Rosenthal PJ, McKerrow JH, Rasnick D, Leech JH. PMID: 2671722.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    273. Extracellular proteases of Onchocerca. Exp Parasitol. 1989 Feb; 68(2):176-85. Lackey A, James ER, Sakanari JA, Resnick SD, Brown M, Bianco AE, McKerrow JH. PMID: 2647506.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    274. Parasite proteases. Exp Parasitol. 1989 Jan; 68(1):111-5. McKerrow JH. PMID: 2645160.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    275. Schistosome proteases. Parasitol Today. 1988 Dec; 4(12):334-40. McKerrow JH, Doenhoff MJ. PMID: 15463025.
      View in: PubMed   Mentions: 20     Fields:    
    276. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov; 82(5):1560-6. Rosenthal PJ, McKerrow JH, Aikawa M, Nagasawa H, Leech JH. PMID: 3053784.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    277. The Schistosomatium douthitti cercarial elastase is biochemically and structurally distinct from that of Schistosoma mansoni. Mol Biochem Parasitol. 1988 Mar; 28(2):113-20. Amiri P, Sakanari J, Basch P, Newport G, McKerrow JH. PMID: 2452979.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    278. Proteinase production by the parasitic cycle of the pathogenic fungus Coccidioides immitis. Infect Immun. 1987 Nov; 55(11):2807-15. Resnick S, Pappagianis D, McKerrow JH. PMID: 3312014.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    279. Molecular cloning of Schistosoma mansoni myosin. Mol Biochem Parasitol. 1987 Nov; 26(1-2):29-38. Newport GR, Harrison RA, McKerrow J, Tarr P, Kallestad J, Agabian N. PMID: 3431565.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    280. Schistosoma mansoni: purification and characterization of the major acidic proteinase from adult worms. Exp Parasitol. 1986 Jun; 61(3):398-404. Lindquist RN, Senft AW, Petitt M, McKerrow J. PMID: 3519269.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    281. The major neutral proteinase of Entamoeba histolytica. J Exp Med. 1986 Mar 01; 163(3):536-49. Keene WE, Petitt MG, Allen S, McKerrow JH. PMID: 2869098.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    282. Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1985 Aug; 16(2):185-98. Dovey HF, McKerrow JH, Wang CC. PMID: 3929087.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    283. Isolation and characterization of a proteolytic enzyme from the adult hookworm Ancylostoma caninum. J Biol Chem. 1985 Jun 25; 260(12):7343-8. Hotez PJ, Trang NL, McKerrow JH, Cerami A. PMID: 3888998.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    284. Schistosoma mansoni: degradation of host extracellular matrix by eggs and miracidia. Exp Parasitol. 1985 Apr; 59(2):217-21. Pino-Heiss S, Brown M, McKerrow JH. PMID: 3882446.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    285. Purine salvage in Schistosoma mansoni schistosomules. Mol Biochem Parasitol. 1984 Apr; 11:157-67. Dovey HF, McKerrow JH, Wang CC. PMID: 6431283.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    286. Degradation of extracellular matrix by larvae of Schistosoma mansoni. I. Degradation by cercariae as a model for initial parasite invasion of host. Lab Invest. 1983 Aug; 49(2):195-200. McKerrow JH, Keene WE, Jeong KH, Werb Z. PMID: 6876746.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    287. Degradation of extracellular matrix by larvae of Schistosoma mansoni. II. Degradation by newly transformed and developing schistosomula. Lab Invest. 1983 Aug; 49(2):201-7. Keene WE, Jeong KH, McKerrow JH, Werb Z. PMID: 6876747.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    288. Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. Exp Parasitol. 1982 Apr; 53(2):249-54. McKerrow JH, Jeong KH. PMID: 7060706.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    289. Primary sequence dependence of the deamidation of rabbit muscle aldolase. Science. 1974 Jan 11; 183(4120):85. McKerrow JH, Robinson AB. PMID: 4808790.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
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