Sandra Leibel

Title(s)Associate Clinical Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, TorontoBSc06/2002Molecular Biology
    Jagiellonian University School of Medicine, KrakowMD05/2006Medicine
    University of Utah Medical Center, Salt Lake City, UTPediatric Residency06/2009Pediatrics
    Washington University, St. LouisNeonatal Fellowship06/2012Neonatology
    University of Toronto, TorontoMSc11/2016Lung Biology
    Collapse Awards and Honors
    Pediatric Academic Societies Meeting2008SPR House Officer Research Award
    Pediatric Academic Societies Meeting2010SPR Travel Award
    Pediatric Academic Societies Meeting2012SPR Travel Award
    Washington University2012Outstanding Fellow Teaching Award
    Western Medical Research Conference2018WSPR Mead Johnson Nutrition Junior Faculty Travel Award
    UCSD/Rady Children’s Hospital2018Fellow Teaching Award
    Western Medical Research Conference2021WSPR Mean Johnson Nutrition Junior Faculty Travel Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Using hiPSC-derived lung organoids, a clinically-relevant system, to validate & winnow a list of approved drugs that inhibit SARS-CoV-2 cytopathy
    CIRM DISC2COVID19-12022Aug 1, 2020 - Jul 31, 2021
    Role: Co-PI
    Description: Establish pluripotent stem cell based lung organoid system to emulate that in vivo conditions for SARS-CoV-2 infection and identify extant drugs that are effective in the patient representative platform.
    SARS-CoV-2 proteome interaction with host transcriptome
    UCSD/UCOP R00RG2636Apr 15, 2020 - Oct 14, 2021
    Role: Co-PI
    Description: This study will address how proteins from SARS-CoV-2 interact with host cell transcriptome in order to understand the varying degrees of clinical manifestation of COVID-19 and to identify molecular targets that can abolish critical viral-host interaction.
    The Association Between Milk Feedings, the Microbiome and Risk of Atopic Disease in the Preterm Population (MAP) Study
    Center for Microbiome Innovation CMI Pilot grantJun 15, 2019 - Dec 14, 2021
    Role: Co-investigator
    Description: Major goals are to examine the microbiome of the preterm gut and mouth along with the milk feeds and determine if a specific pattern predisposes preterm babies to develop atopy.
    Lung Organoids as a model system for studying the impact of surfactant B deficiency on lung development
    UCSD Academic Senate RS282R-LEIBELJan 1, 2018 - Dec 31, 2019
    Role: PI
    Description: Major goal was to study and rescue surfactant protein B deficiency using gene therapy with a lentivirus in human lung organoid model.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies. Commun Biol. 2022 08 05; 5(1):789. Li R, Mor M, Ma B, Clark AE, Alter J, Werbner M, Lee JC, Leibel SL, Carlin AF, Dessau M, Gal-Tanamy M, Croker BA, Xiang Y, Freund NT. PMID: 35931732; PMCID: PMC9355996.
      View in: PubMed   Mentions:
    2. Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern. PLoS Pathog. 2022 07; 18(7):e1010686. Almanza G, Clark AE, Kouznetsova V, Olmedillas E, Castro A, Tsigelny IF, Wu Y, Gao GF, Leibel SL, Bray W, Ollmann Saphire E, Carlin AF, Zanetti M. PMID: 35862442; PMCID: PMC9302722.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    3. Immune-Mediated Neonatal Thrombocytopenia. Neoreviews. 2022 07 01; 23(7):e462-e471. Batton E, Leibel SL. PMID: 35773506.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study). Sci Rep. 2022 04 19; 12(1):6437. Bai-Tong SS, Thoemmes MS, Weldon KC, Motazavi D, Kitsen J, Hansen S, Furst A, Geng B, Song SJ, Gilbert JA, Bode L, Dorrestein PC, Knight R, Leibel SA, Leibel SL. PMID: 35440708; PMCID: PMC9018729.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions. Res Sq. 2022 Mar 17. Yeo G, Xiang J, Mueller J, Luo EC, Yee B, Schafer D, Schmok J, Tan F, Rothamel K, McVicar R, Kwong E, Croker B, Jones K, Her HL, Chen CY, Vu A, Jin W, Park S, Le P, Brennan K, Kofman E, Li Y, Tankka A, Dong K, Song Y, Clark A, Carlin A, Nostrand EV, Leibel S. PMID: 35313591; PMCID: PMC8936114.
      View in: PubMed   Mentions:
    6. Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions. bioRxiv. 2022 Feb 23. Xiang JS, Mueller JR, Luo EC, Yee BA, Schafer D, Schmok JC, Tan FE, Rothamel K, McVicar RN, Kwong EM, Jones KL, Her HL, Chen CY, Vu AQ, Jin W, Park SS, Le P, Brannan KW, Kofman ER, Li Y, Tankka AT, Dong KD, Song Y, Carlin AF, Van Nostrand EL, Leibel SL, Yeo GW. PMID: 35233578; PMCID: PMC8887137.
      View in: PubMed   Mentions:
    7. Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors. iScience. 2022 Feb 18; 25(2):103797. Leibel SL, Tseu I, Zhou A, Hodges A, Yin J, Bilodeau C, Goltsis O, Post M. PMID: 35198866; PMCID: PMC8850758.
      View in: PubMed   Mentions:
    8. Analysis of SARS-CoV-2 RNA Persistence across Indoor Surface Materials Reveals Best Practices for Environmental Monitoring Programs. mSystems. 2021 Dec 21; 6(6):e0113621. Salido RA, Cantú VJ, Clark AE, Leibel SL, Foroughishafiei A, Saha A, Hakim A, Nouri A, Lastrella AL, Castro-Martínez A, Plascencia A, Kapadia BK, Xia B, Ruiz CA, Marotz CA, Maunder D, Lawrence ES, Smoot EW, Eisner E, Crescini ES, Kohn L, Franco Vargas L, Chacón M, Betty M, Machnicki M, Wu MY, Baer NA, Belda-Ferre P, De Hoff P, Seaver P, Ostrander RT, Tsai R, Sathe S, Aigner S, Morgan SC, Ngo TT, Barber T, Cheung W, Carlin AF, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 34726486; PMCID: PMC8562474.
      View in: PubMed   Mentions: 2  
    9. COVID-19 in Early Life: Infants and Children Are Affected Too. Physiology (Bethesda). 2021 11 01; 36(6):359-366. Leibel SL, Sun X. PMID: 34704855; PMCID: PMC8560374.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    10. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34). Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. PMID: 34407940; PMCID: PMC8373124.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0115521. Schooley RT, Carlin AF, Beadle JR, Valiaeva N, Zhang XQ, Clark AE, McMillan RE, Leibel SL, McVicar RN, Xie J, Garretson AF, Smith VI, Murphy J, Hostetler KY. PMID: 34310217; PMCID: PMC8448143.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    12. Comparison of heat-inactivated and infectious SARS-CoV-2 across indoor surface materials shows comparable RT-qPCR viral signal intensity and persistence. bioRxiv. 2021 Jul 19. Salido RA, Cantú VJ, Clark AE, Leibel SL, Foroughishafiei A, Saha A, Hakim A, Nouri A, Lastrella AL, Castro-Martínez A, Plascencia A, Kapadia B, Xia B, Ruiz C, Marotz CA, Maunder D, Lawrence ES, Smoot EW, Eisner E, Crescini ES, Kohn L, Franco Vargas L, Chacón M, Betty M, Machnicki M, Wu MY, Baer NA, Belda-Ferre P, De Hoff P, Seaver P, Ostrander RT, Tsai R, Sathe S, Aigner S, Morgan SC, Ngo TT, Barber T, Cheung W, Carlin AF, Yeo GW, Laurent LC, Fielding-Miller R, Knight R. PMID: 34312621; PMCID: PMC8312891.
      View in: PubMed   Mentions:
    13. Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs. bioRxiv. 2021 Jun 07. Schooley RT, Carlin AF, Beadle JR, Valiaeva N, Zhang XQ, Clark AE, McMillan RE, Leibel SL, McVicar RN, Xie J, Garretson AF, Smith VI, Murphy J, Hostetler KY. PMID: 32869033; PMCID: PMC7457622.
      View in: PubMed   Mentions:
    14. Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease. J Vis Exp. 2021 04 12; (170). Leibel SL, McVicar RN, Winquist AM, Snyder EY. PMID: 33900299.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection. bioRxiv. 2021 Mar 26. Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM. PMID: 33791697; PMCID: PMC8010724.
      View in: PubMed   Mentions:
    16. Halting SARS-CoV-2: lung organoids step up to the plate. EMBO J. 2021 03 01; 40(5):e107651. Leibel SL, Sun X. PMID: 33576058; PMCID: PMC7917546.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors. PLoS Pathog. 2021 02; 17(2):e1009165. Mor M, Werbner M, Alter J, Safra M, Chomsky E, Lee JC, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Ben-Shalom N, Navon M, Rafael D, Sharim H, Kiner E, Griffis ER, Gershoni JM, Kobiler O, Leibel SL, Zimhony O, Carlin AF, Yaari G, Dessau M, Gal-Tanamy M, Hagin D, Croker BA, Freund NT. PMID: 33571304; PMCID: PMC7877634.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors. bioRxiv. 2020 Oct 06. Mor M, Werbner M, Alter J, Safra M, Chomsky E, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Shalom NB, Navon M, Rafael D, Sharim H, Kiner E, Griffis E, Gershoni JM, Kobiler O, Leibel SL, Zimhony O, Carlin AF, Yaari G, Dassau M, Gal-Tanamy M, Hagin D, Croker BA, Freund NT. PMID: 33052341; PMCID: PMC7553166.
      View in: PubMed   Mentions:
    19. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020 11 12; 183(4):1043-1057.e15. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32970989; PMCID: PMC7489987.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansCellsPHPublic Health
    20. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Curr Protoc Stem Cell Biol. 2020 09; 54(1):e118. Leibel SL, McVicar RN, Winquist AM, Niles WD, Snyder EY. PMID: 32640120; PMCID: PMC7361156.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsPHPublic Health
    21. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020 Jul 14. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32699853; PMCID: PMC7373134.
      View in: PubMed   Mentions:
    22. Comparison of Continuous positive airway pressure versus High flow nasal cannula for Oral feeding Preterm infants (CHOmP): randomized pilot study. J Matern Fetal Neonatal Med. 2022 Mar; 35(5):951-957. Leibel SL, Castro M, McBride T, Hassall K, Sarmiento K, Ye XY, Shah V. PMID: 32138561.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy. Sci Rep. 2019 09 17; 9(1):13450. Leibel SL, Winquist A, Tseu I, Wang J, Luo D, Shojaie S, Nathan N, Snyder E, Post M. PMID: 31530844; PMCID: PMC6748939.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Chronic lung disease in preterm infants receiving various modes of noninvasive ventilation at ≤30 weeks' postmenstrual age. J Matern Fetal Neonatal Med. 2020 May; 33(9):1466-1472. Leibel SL, Ye XY, Shah P, Shah V, Canadian Neonatal Network. PMID: 30176762.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC. Pediatr Res. 2018 09; 84(3):419-425. Attarian SJ, Leibel SL, Yang P, Alfano DN, Hackett BP, Cole FS, Hamvas A. PMID: 29538355; PMCID: PMC6599453.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. Endogenous and Exogenous Stem/Progenitor Cells in the Lung and Their Role in the Pathogenesis and Treatment of Pediatric Lung Disease. Front Pediatr. 2016; 4:36. Leibel S, Post M. PMID: 27148506; PMCID: PMC4830813.
      View in: PubMed   Mentions: 6  
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