Sandra Leibel

Title(s)Assistant Clinical Professor, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of Toronto, TorontoBSc06/2002Molecular Biology
    Jagiellonian University School of Medicine, KrakowMD05/2006Medicine
    University of Utah Medical Center, Salt Lake City, UTPediatric Residency06/2009Pediatrics
    Washington University, St. LouisNeonatal Fellowship06/2012Neonatology
    University of Toronto, TorontoMSc11/2016Lung Biology
    Collapse Awards and Honors
    Pediatric Academic Societies Meeting2008SPR House Officer Research Award
    Pediatric Academic Societies Meeting2010SPR Travel Award
    Pediatric Academic Societies Meeting2012SPR Travel Award
    Washington University2012Outstanding Fellow Teaching Award
    Western Medical Research Conference2018WSPR Mead Johnson Nutrition Junior Faculty Travel Award
    UCSD/Rady Children’s Hospital2018Fellow Teaching Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Using hiPSC-derived lung organoids, a clinically-relevant system, to validate & winnow a list of approved drugs that inhibit SARS-CoV-2 cytopathy
    CIRM DISC2COVID19-12022Aug 1, 2020 - Jul 31, 2021
    Role: Co-PI
    Role Description: Establish pluripotent stem cell based lung organoid system to emulate that in vivo conditions for SARS-CoV-2 infection and identify extant drugs that are effective in the patient representative platform.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease. J Vis Exp. 2021 04 12; (170). Leibel SL, McVicar RN, Winquist AM, Snyder EY. PMID: 33900299.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection. bioRxiv. 2021 Mar 26. Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM. PMID: 33791697.
      View in: PubMed   Mentions:
    3. Halting SARS-CoV-2: lung organoids step up to the plate. EMBO J. 2021 03 01; 40(5):e107651. Leibel SL, Sun X. PMID: 33576058.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors. PLoS Pathog. 2021 02; 17(2):e1009165. Mor M, Werbner M, Alter J, Safra M, Chomsky E, Lee JC, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Ben-Shalom N, Navon M, Rafael D, Sharim H, Kiner E, Griffis ER, Gershoni JM, Kobiler O, Leibel SL, Zimhony O, Carlin AF, Yaari G, Dessau M, Gal-Tanamy M, Hagin D, Croker BA, Freund NT. PMID: 33571304.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors. bioRxiv. 2020 Oct 06. Mor M, Werbner M, Alter J, Safra M, Chomsky E, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Shalom NB, Navon M, Rafael D, Sharim H, Kiner E, Griffis E, Gershoni JM, Kobiler O, Leibel SL, Zimhony O, Carlin AF, Yaari G, Dassau M, Gal-Tanamy M, Hagin D, Croker BA, Freund NT. PMID: 33052341.
      View in: PubMed   Mentions:
    6. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020 11 12; 183(4):1043-1057.e15. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32970989.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansCellsPHPublic Health
    7. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Curr Protoc Stem Cell Biol. 2020 09; 54(1):e118. Leibel SL, McVicar RN, Winquist AM, Niles WD, Snyder EY. PMID: 32640120.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    8. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020 Jul 14. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. PMID: 32699853.
      View in: PubMed   Mentions:
    9. Comparison of Continuous positive airway pressure versus High flow nasal cannula for Oral feeding Preterm infants (CHOmP): randomized pilot study. J Matern Fetal Neonatal Med. 2020 Mar 05; 1-7. Leibel SL, Castro M, McBride T, Hassall K, Sarmiento K, Ye XY, Shah V. PMID: 32138561.
      View in: PubMed   Mentions: 1     Fields:    
    10. Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy. Sci Rep. 2019 09 17; 9(1):13450. Leibel SL, Winquist A, Tseu I, Wang J, Luo D, Shojaie S, Nathan N, Snyder E, Post M. PMID: 31530844.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Chronic lung disease in preterm infants receiving various modes of noninvasive ventilation at ≤30 weeks' postmenstrual age. J Matern Fetal Neonatal Med. 2020 May; 33(9):1466-1472. Leibel SL, Ye XY, Shah P, Shah V, Canadian Neonatal Network . PMID: 30176762.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC. Pediatr Res. 2018 09; 84(3):419-425. Attarian SJ, Leibel SL, Yang P, Alfano DN, Hackett BP, Cole FS, Hamvas A. PMID: 29538355.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Endogenous and Exogenous Stem/Progenitor Cells in the Lung and Their Role in the Pathogenesis and Treatment of Pediatric Lung Disease. Front Pediatr. 2016; 4:36. Leibel S, Post M. PMID: 27148506.
      View in: PubMed   Mentions:
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