|Using hiPSC-derived lung organoids, a clinically-relevant system, to validate & winnow a list of approved drugs that inhibit SARS-CoV-2 cytopathy|
CIRM DISC2COVID19-12022Aug 1, 2020 - Jul 31, 2021
Description: Establish pluripotent stem cell based lung organoid system to emulate that in vivo conditions for SARS-CoV-2 infection and identify extant drugs that are effective in the patient representative platform.
|SARS-CoV-2 proteome interaction with host transcriptome|
UCSD/UCOP R00RG2636Apr 15, 2020 - Oct 14, 2021
Description: This study will address how proteins from SARS-CoV-2 interact with host cell transcriptome in order to understand the varying degrees of clinical manifestation of COVID-19 and to identify molecular targets that can abolish critical viral-host interaction.
|The Association Between Milk Feedings, the Microbiome and Risk of Atopic Disease in the Preterm Population (MAP) Study|
Center for Microbiome Innovation CMI Pilot grantJun 15, 2019 - Dec 14, 2021
Description: Major goals are to examine the microbiome of the preterm gut and mouth along with the milk feeds and determine if a specific pattern predisposes preterm babies to develop atopy.
|Lung Organoids as a model system for studying the impact of surfactant B deficiency on lung development|
UCSD Academic Senate RS282R-LEIBELJan 1, 2018 - Dec 31, 2019
Description: Major goal was to study and rescue surfactant protein B deficiency using gene therapy with a lentivirus in human lung organoid model.