Bradley Moore

InstitutionUniversity of California San Diego
DepartmentSchool of Pharmacy and Pharmaceutical Science
Address9500 Gilman Drive #0204
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeted discovery of antibiotics from cave bacteria
    NIH/NIAID R01AI117712Mar 1, 2016 - Feb 28, 2020
    Role: Principal Investigator
    Scripps Center for Ocean and Human Health
    NIH/NIEHS P01ES021921Sep 24, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Experiment based genome mining of ribosomal natural products
    NIH/NIGMS R01GM097509Apr 1, 2012 - Feb 29, 2016
    Role: Principal Investigator
    Natural Product Genome Mining
    NIH/NIGMS R01GM085770Aug 1, 2009 - Jul 31, 2021
    Role: Principal Investigator
    Salinosporamide Biosynthesis and Engineering
    NIH/NCI R01CA127622Apr 1, 2007 - May 31, 2017
    Role: Principal Investigator
    Type III Polyketide Synthases: Structure and Mechanism
    NIH/NIAID R01AI052443Jun 15, 2002 - May 31, 2008
    Role: Principal Investigator
    Biosynthesis of marine polyketide antibiotics
    NIH/NIAID R01AI047818Aug 1, 2000 - Dec 31, 2022
    Role: Principal Investigator
    Biosynthesis of Marine Polyketide Antibiotics
    NIH/NIAID R56AI047818Aug 1, 2000 - Aug 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore B, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat Prod Rep. 2018 Jul 13. PMID: 30003207.
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    2. Murray L, McKinnie S, Pepper H, Erni R, Miles Z, Cruickshank M, Lopez-Perez B, Moore B, George JH. Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angew Chem Int Ed Engl. 2018 Jun 23. PMID: 29935040.
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    3. Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore B, Pessah IN. Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol. 2018 Jun 19. PMID: 29916692.
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    4. Saleem-Batcha R, Stull F, Sanders JN, Moore B, Palfey BA, Houk KN, Teufel R. Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. Proc Natl Acad Sci U S A. 2018 May 08; 115(19):4909-4914. PMID: 29686059.
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    5. Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore B, Pessah IN. Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics. Environ Sci Technol. 2018 May 01; 52(9):5469-5478. PMID: 29617551.
      View in: PubMed
    6. McKinnie SMK, Miles ZD, Moore B. Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases. Methods Enzymol. 2018; 604:405-424. PMID: 29779661.
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    7. Chekan JR, Moore B. Preparation and Characterization of Tetrabromopyrrole Debrominase From Marine Proteobacteria. Methods Enzymol. 2018; 605:253-265. PMID: 29909826.
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    8. Chekan JR, Moore B. Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria. Biochemistry. 2018 02 13; 57(6):897-898. PMID: 29313351.
      View in: PubMed
    9. Moore B. Natural Product Reports 35 years on. Nat Prod Rep. 2018 Jan 01; 35(1):6-7. PMID: 29367974.
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    10. Moore B. Preface. Methods Enzymol. 2018; 604:xv-xvi. PMID: 29779668.
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    11. Moore B. Preface. Methods Enzymol. 2018; 605:xv-xvi. PMID: 29909840.
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    12. Reynolds KA, Luhavaya H, Li J, Dahesh S, Nizet V, Yamanaka K, Moore B. Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster. J Antibiot (Tokyo). 2018 Feb; 71(2):333-338. PMID: 29184121.
      View in: PubMed
    13. Zhang JJ, Tang X, Zhang M, Nguyen D, Moore B. Broad-Host-Range Expression Reveals Native and Host Regulatory Elements That Influence Heterologous Antibiotic Production in Gram-Negative Bacteria. MBio. 2017 Sep 05; 8(5). PMID: 28874475.
      View in: PubMed
    14. Simmons RA, Cosgrove SC, Romney MC, Plumb JD, Brawer RO, Gonzalez ET, Fleisher LG, Moore B. Health Literacy: Cancer Prevention Strategies for Early Adults. Am J Prev Med. 2017 Sep; 53(3S1):S73-S77. PMID: 28818249.
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    15. Li J, Tang X, Awakawa T, Moore B. Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity. Angew Chem Int Ed Engl. 2017 Sep 25; 56(40):12234-12239. PMID: 28833969.
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    16. Bruns H, Crüsemann M, Letzel AC, Alanjary M, McInerney JO, Jensen PR, Schulz S, Moore B, Ziemert N. Function-related replacement of bacterial siderophore pathways. ISME J. 2018 Feb; 12(2):320-329. PMID: 28809850.
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    17. Letzel AC, Li J, Amos GCA, Millán-Aguiñaga N, Ginigini J, Abdelmohsen UR, Gaudêncio SP, Ziemert N, Moore B, Jensen PR. Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environ Microbiol. 2017 Sep; 19(9):3660-3673. PMID: 28752948.
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    18. Miles ZD, Diethelm S, Pepper HP, Huang DM, George JH, Moore B. A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis. Nat Chem. 2017 Dec; 9(12):1235-1242. PMID: 29168495.
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    19. Moore B, Carter GT, Brönstrup M. Editorial: Are natural products the solution to antimicrobial resistance? Nat Prod Rep. 2017 07 01; 34(7):685-686. PMID: 28671218.
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    20. Tang X, Li J, Moore B. Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation. Chembiochem. 2017 06 19; 18(12):1072-1076. PMID: 28393452.
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    21. Larson CB, Crüsemann M, Moore B. PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete. J Nat Prod. 2017 Apr 28; 80(4):1200-1204. PMID: 28333450.
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    22. Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore B. Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol. 2017 05; 13(5):537-543. PMID: 28319100.
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    23. Patin NV, Schorn M, Aguinaldo K, Lincecum T, Moore B, Jensen PR. Effects of Actinomycete Secondary Metabolites on Sediment Microbial Communities. Appl Environ Microbiol. 2017 Feb 15; 83(4). PMID: 27986719.
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    24. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore B, Medema MH, Dorrestein PC. Erratum: Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2017 01 23; 2:17010. PMID: 28112718.
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    25. Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore B. Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse. Chem Rev. 2017 Apr 26; 117(8):5619-5674. PMID: 28106994.
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    26. Jordan PA, Moore B. Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids. Cell Chem Biol. 2016 Dec 22; 23(12):1504-1514. PMID: 27866908.
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    27. Zhang W, Lu L, Lai Q, Zhu B, Li Z, Xu Y, Shao Z, Herrup K, Moore B, Ross AC, Qian PY. Family-wide Structural Characterization and Genomic Comparisons Decode the Diversity-oriented Biosynthesis of Thalassospiramides by Marine Proteobacteria. J Biol Chem. 2016 12 30; 291(53):27228-27238. PMID: 27875306.
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    28. Crüsemann M, O'Neill EC, Larson CB, Melnik AV, Floros DJ, da Silva RR, Jensen PR, Dorrestein PC, Moore B. Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols. J Nat Prod. 2017 Mar 24; 80(3):588-597. PMID: 28335604.
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    29. Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, De Mot R, Moore B, Medema MH, Dorrestein PC. Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nat Microbiol. 2016 10 31; 2:16197. PMID: 27798598.
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    30. Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore B. Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology. 2016 12; 162(12):2075-2086. PMID: 27902408.
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    31. El Gamal A, Agarwal V, Rahman I, Moore B. Enzymatic Reductive Dehalogenation Controls the Biosynthesis of Marine Bacterial Pyrroles. J Am Chem Soc. 2016 10 12; 138(40):13167-13170. PMID: 27676265.
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    32. Groenhagen U, Leandrini De Oliveira AL, Fielding E, Moore B, Schulz S. Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica. Chembiochem. 2016 10 17; 17(20):1978-1985. PMID: 27490971.
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    33. Li ZR, Li J, Gu JP, Lai JY, Duggan BM, Zhang WP, Li ZL, Li YX, Tong RB, Xu Y, Lin DH, Moore B, Qian PY. Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nat Chem Biol. 2016 10; 12(10):773-5. PMID: 27547923.
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    34. Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore B, Dorrestein PC, Bandeira N. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol. 2016 08 09; 34(8):828-837. PMID: 27504778.
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    35. El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel JP, Paul VJ, Moore B. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):3797-802. PMID: 27001835; PMCID: PMC4833250 [Available on 10/05/16].
    36. Harvey EL, Deering RW, Rowley DC, El Gamal A, Schorn M, Moore B, Johnson MD, Mincer TJ, Whalen KE. A Bacterial Quorum-Sensing Precursor Induces Mortality in the Marine Coccolithophore, Emiliania huxleyi. Front Microbiol. 2016; 7:59. PMID: 26870019; PMCID: PMC4737879.
    37. Ray L, Moore B. Recent advances in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep. 2016 Feb; 33(2):150-61. PMID: 26571143; PMCID: PMC4742410 [Available on 02/04/17].
    38. Teufel R, Agarwal V, Moore B. Unusual flavoenzyme catalysis in marine bacteria. Curr Opin Chem Biol. 2016 Apr; 31:31-9. PMID: 26803009; PMCID: PMC4870101 [Available on 04/01/17].
    39. Ray L, Yamanaka K, Moore B. A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis. Angew Chem Int Ed Engl. 2016 Jan 04; 55(1):364-7. PMID: 26553755; PMCID: PMC4715598 [Available on 01/04/17].
    40. Kim E, Moore B, Yoon YJ. Erratum: Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015 Nov; 11(11):887. PMID: 26485082.
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    41. Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore B. Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining. ACS Chem Biol. 2015 Dec 18; 10(12):2841-2849. PMID: 26458099; PMCID: PMC4758359 [Available on 12/18/16].
    42. Agarwal V, Diethelm S, Ray L, Garg N, Awakawa T, Dorrestein PC, Moore B. Chemoenzymatic Synthesis of Acyl Coenzyme A Substrates Enables in Situ Labeling of Small Molecules and Proteins. Org Lett. 2015 Sep 18; 17(18):4452-5. PMID: 26333306; PMCID: PMC4720141.
    43. Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore B, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Sep; 11(9):625-31. PMID: 26284661.
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    44. Kim E, Moore B, Yoon YJ. Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015 Sep; 11(9):649-59. PMID: 26284672; PMCID: PMC4757526.
    45. Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein PC, Palfey B, Moore B. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. J Am Chem Soc. 2015 Jul 01; 137(25):8078-85. PMID: 26067765; PMCID: PMC4720136.
    46. Cha JY, Han S, Hong HJ, Cho H, Kim D, Kwon Y, Kwon SK, Crüsemann M, Bok Lee Y, Kim JF, Giaever G, Nislow C, Moore B, Thomashow LS, Weller DM, Kwak YS. Microbial and biochemical basis of a Fusarium wilt-suppressive soil. ISME J. 2016 Jan; 10(1):119-29. PMID: 26057845; PMCID: PMC4681868 [Available on 01/01/17].
    47. Awakawa T, Crüsemann M, Munguia J, Ziemert N, Nizet V, Fenical W, Moore B. Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase. Chembiochem. 2015 Jul 06; 16(10):1443-7. PMID: 25930739; PMCID: PMC4545249.
    48. Jensen PR, Moore B, Fenical W. The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery. Nat Prod Rep. 2015 May; 32(5):738-51. PMID: 25730728; PMCID: PMC4414829.
    49. Duncan KR, Crüsemann M, Lechner A, Sarkar A, Li J, Ziemert N, Wang M, Bandeira N, Moore B, Dorrestein PC, Jensen PR. Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol. 2015 Apr 23; 22(4):460-471. PMID: 25865308; PMCID: PMC4409930.
    50. Moore B, Gerwick WH. Special issue in honor of William Fenical, a pioneer in marine natural products discovery and drug development. J Nat Prod. 2015 Mar 27; 78(3):347-8. PMID: 25814030.
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    51. Li Y, Li Z, Yamanaka K, Xu Y, Zhang W, Vlamakis H, Kolter R, Moore B, Qian PY. Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. Sci Rep. 2015 Mar 24; 5:9383. PMID: 25807046; PMCID: PMC4894447.
    52. Lu L, Meehan MJ, Gu S, Chen Z, Zhang W, Zhang G, Liu L, Huang X, Dorrestein PC, Xu Y, Moore B, Qian PY. Mechanism of action of thalassospiramides, a new class of calpain inhibitors. Sci Rep. 2015 Mar 05; 5:8783. PMID: 25740631; PMCID: PMC4350077.
    53. Zhang JJ, Moore B. Digging for biosynthetic dark matter. Elife. 2015 Feb 13; 4:e06453. PMID: 25687291; PMCID: PMC4337655.
    54. Agarwal V, Li J, Rahman I, Borgen M, Aluwihare LI, Biggs JS, Paul VJ, Moore B. Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. Environ Sci Technol. 2015 Feb 03; 49(3):1339-46. PMID: 25559102; PMCID: PMC4358748.
    55. Richter TK, Hughes CC, Moore B. Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environ Microbiol. 2015 Jun; 17(6):2158-71. PMID: 25329237; PMCID: PMC4755588.
    56. Bonet B, Teufel R, Crüsemann M, Ziemert N, Moore B. Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. J Nat Prod. 2015 Mar 27; 78(3):539-42. PMID: 25382643; PMCID: PMC4380194.
    57. Xu M, Hillwig ML, Lane AL, Tiernan MS, Moore B, Peters RJ. Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. J Nat Prod. 2014 Sep 26; 77(9):2144-7. PMID: 25203741; PMCID: PMC4176389.
    58. Ross AC, Gulland LE, Dorrestein PC, Moore B. Targeted capture and heterologous expression of the Pseudoalteromonas alterochromide gene cluster in Escherichia coli represents a promising natural product exploratory platform. ACS Synth Biol. 2015 Apr 17; 4(4):414-20. PMID: 25140825; PMCID: PMC4410906.
    59. Diethelm S, Teufel R, Kaysser L, Moore B. A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):11023-6. PMID: 25147132; PMCID: PMC4226426.
    60. Teufel R, Kaysser L, Villaume MT, Diethelm S, Carbullido MK, Baran PS, Moore B. One-pot enzymatic synthesis of merochlorin A and B. Angew Chem Int Ed Engl. 2014 Oct 06; 53(41):11019-22. PMID: 25115835; PMCID: PMC4229033.
    61. Agarwal V, Moore B. Fungal polyketide engineering comes of age. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12278-9. PMID: 25118274; PMCID: PMC4151771.
    62. Mohimani H, Liu WT, Kersten RD, Moore B, Dorrestein PC, Pevzner PA. NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery. J Nat Prod. 2014 Aug 22; 77(8):1902-9. PMID: 25116163; PMCID: PMC4143176.
    63. Agarwal V, Moore B. Enzymatic synthesis of polybrominated dioxins from the marine environment. ACS Chem Biol. 2014 Sep 19; 9(9):1980-4. PMID: 25061970; PMCID: PMC4168793.
    64. Agarwal V, El Gamal AA, Yamanaka K, Poth D, Kersten RD, Schorn M, Allen EE, Moore B. Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol. 2014 Aug; 10(8):640-7. PMID: 24974229; PMCID: PMC4104138.
    65. Trivella DB, Pereira AR, Stein ML, Kasai Y, Byrum T, Valeriote FA, Tantillo DJ, Groll M, Gerwick WH, Moore B. Enzyme inhibition by hydroamination: design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chem Biol. 2014 Jun 19; 21(6):782-91. PMID: 24930969; PMCID: PMC4103027.
    66. Mohimani H, Kersten RD, Liu WT, Wang M, Purvine SO, Wu S, Brewer HM, Pasa-Tolic L, Bandeira N, Moore B, Pevzner PA, Dorrestein PC. Automated genome mining of ribosomal peptide natural products. ACS Chem Biol. 2014 Jul 18; 9(7):1545-51. PMID: 24802639; PMCID: PMC4215869.
    67. Niewerth D, Jansen G, Riethoff LF, van Meerloo J, Kale AJ, Moore B, Assaraf YG, Anderl JL, Zweegman S, Kaspers GJ, Cloos J. Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor salinosporamide A (Marizomib). Mol Pharmacol. 2014 Jul; 86(1):12-9. PMID: 24737138; PMCID: PMC4054006.
    68. Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore B. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1957-62. PMID: 24449899; PMCID: PMC3918841.
    69. Jordan PA, Moore B. Biosynthesis: Non-stick natural products. Nat Chem. 2014 Jan; 6(1):10-2. PMID: 24345935.
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    70. Mantovani SM, Moore B. Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine A. J Am Chem Soc. 2013 Dec 04; 135(48):18032-5. PMID: 24246014; PMCID: PMC3887146.
    71. Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore B, Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem Biol. 2014 Jan 17; 9(1):301-9. PMID: 24168704; PMCID: PMC4041076.
    72. Kersten RD, Ziemert N, Gonzalez DJ, Duggan BM, Nizet V, Dorrestein PC, Moore B. Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4407-16. PMID: 24191063; PMCID: PMC3839717.
    73. Teufel R, Miyanaga A, Michaudel Q, Stull F, Louie G, Noel JP, Baran PS, Palfey B, Moore B. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature. 2013 Nov 28; 503(7477):552-556. PMID: 24162851; PMCID: PMC3844076.
    74. Liu WT, Lamsa A, Wong WR, Boudreau PD, Kersten R, Peng Y, Moree WJ, Duggan BM, Moore B, Gerwick WH, Linington RG, Pogliano K, Dorrestein PC. MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo). 2014 Jan; 67(1):99-104. PMID: 24149839; PMCID: PMC3919142.
    75. Jensen PR, Chavarria KL, Fenical W, Moore B, Ziemert N. Challenges and triumphs to genomics-based natural product discovery. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):203-9. PMID: 24104399; PMCID: PMC3946964.
    76. Horsman GP, Lechner A, Ohnishi Y, Moore B, Shen B. Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry. 2013 Aug 06; 52(31):5217-24. PMID: 23844627; PMCID: PMC3849214.
    77. Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, Kersten RD, Mehnaz S, De Mot R, Shank EA, Charusanti P, Nagarajan H, Duggan BM, Moore B, Bandeira N, Palsson BØ, Pogliano K, Gutiérrez M, Dorrestein PC. MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2611-20. PMID: 23798442; PMCID: PMC3710860.
    78. Lipson JM, Thomsen M, Moore B, Clausen RP, La Clair JJ, Burkart MD. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem. 2013 May 27; 14(8):950-3. PMID: 23650044; PMCID: PMC3749784.
    79. Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore B. Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem. 2013 May 27; 14(8):955-62. PMID: 23649992; PMCID: PMC3755882.
    80. Lane AL, Nam SJ, Fukuda T, Yamanaka K, Kauffman CA, Jensen PR, Fenical W, Moore B. Structures and comparative characterization of biosynthetic gene clusters for cyanosporasides, enediyne-derived natural products from marine actinomycetes. J Am Chem Soc. 2013 Mar 20; 135(11):4171-4. PMID: 23458364; PMCID: PMC3611589.
    81. Ross AC, Xu Y, Lu L, Kersten RD, Shao Z, Al-Suwailem AM, Dorrestein PC, Qian PY, Moore B. Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria. J Am Chem Soc. 2013 Jan 23; 135(3):1155-62. PMID: 23270364; PMCID: PMC3563429.
    82. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore B, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60. PMID: 23165928; PMCID: PMC3954855.
    83. Lechner A, Wilson MC, Ban YH, Hwang JY, Yoon YJ, Moore B. Designed biosynthesis of 36-methyl-FK506 by polyketide precursor pathway engineering. ACS Synth Biol. 2013 Jul 19; 2(7):379-83. PMID: 23654255; PMCID: PMC3716868.
    84. Kale AJ, Moore B. Molecular mechanisms of acquired proteasome inhibitor resistance. J Med Chem. 2012 Dec 13; 55(23):10317-27. PMID: 22978849; PMCID: PMC3521846.
    85. Qian Q, Schultz AW, Moore B, Tanner ME. Mechanistic studies on CymD: a tryptophan reverse N-prenyltransferase. Biochemistry. 2012 Oct 02; 51(39):7733-9. PMID: 22935004; PMCID: PMC3475536.
    86. Richter M, Busch B, Ishida K, Moore B, Hertweck C. Pyran formation by an atypical CYP-mediated four-electron oxygenation-cyclization cascade in an engineered aureothin pathway. Chembiochem. 2012 Oct 15; 13(15):2196-9. PMID: 22961965; PMCID: PMC3517090.
    87. Roberts AA, Schultz AW, Kersten RD, Dorrestein PC, Moore B. Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. FEMS Microbiol Lett. 2012 Oct; 335(2):95-103. PMID: 22812504; PMCID: PMC4209017.
    88. Yang JY, Phelan VV, Simkovsky R, Watrous JD, Trial RM, Fleming TC, Wenter R, Moore B, Golden SS, Pogliano K, Dorrestein PC. Primer on agar-based microbial imaging mass spectrometry. J Bacteriol. 2012 Nov; 194(22):6023-8. PMID: 22821974; PMCID: PMC3486372.
    89. Yamanaka K, Ryan KS, Gulder TA, Hughes CC, Moore B. Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. J Am Chem Soc. 2012 Aug 01; 134(30):12434-7. PMID: 22800473; PMCID: PMC3415713.
    90. Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore B. Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. J Am Chem Soc. 2012 Jul 25; 134(29):11988-91. PMID: 22784372; PMCID: PMC3410959.
    91. Watrous J, Roach P, Alexandrov T, Heath BS, Yang JY, Kersten RD, van der Voort M, Pogliano K, Gross H, Raaijmakers JM, Moore B, Laskin J, Bandeira N, Dorrestein PC. Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):E1743-52. PMID: 22586093; PMCID: PMC3387089.
    92. Xu Y, Kersten RD, Nam SJ, Lu L, Al-Suwailem AM, Zheng H, Fenical W, Dorrestein PC, Moore B, Qian PY. Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc. 2012 May 23; 134(20):8625-32. PMID: 22458477; PMCID: PMC3401512.
    93. Pereira AR, Kale AJ, Fenley AT, Byrum T, Debonsi HM, Gilson MK, Valeriote FA, Moore B, Gerwick WH. The carmaphycins: new proteasome inhibitors exhibiting an a,ß-epoxyketone warhead from a marine cyanobacterium. Chembiochem. 2012 Apr 16; 13(6):810-7. PMID: 22383253; PMCID: PMC3393770.
    94. Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore B, Gerwick WH. Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS J. 2012 Apr; 279(7):1243-51. PMID: 22314229.
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    95. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore B, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20; 287(17):13889-98. PMID: 22371493; PMCID: PMC3340166.
    96. Gerwick WH, Moore B. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol. 2012 Jan 27; 19(1):85-98. PMID: 22284357; PMCID: PMC3345185.
    97. Lechner A, Eustáquio AS, Gulder TA, Hafner M, Moore B. Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation. Chem Biol. 2011 Dec 23; 18(12):1527-36. PMID: 22195555; PMCID: PMC3246214.
    98. Wilson MC, Moore B. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Nat Prod Rep. 2012 Jan; 29(1):72-86. PMID: 22124767.
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    99. Liu WT, Kersten RD, Yang YL, Moore B, Dorrestein PC. Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus. J Am Chem Soc. 2011 Nov 16; 133(45):18010-3. PMID: 21999343; PMCID: PMC3251218.
    100. Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore B, Dorrestein PC. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol. 2011 Oct 09; 7(11):794-802. PMID: 21983601; PMCID: PMC3258187.
    101. Kale AJ, McGlinchey RP, Lechner A, Moore B. Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A. ACS Chem Biol. 2011 Nov 18; 6(11):1257-64. PMID: 21882868; PMCID: PMC3220761.
    102. Miyanaga A, Janso JE, McDonald L, He M, Liu H, Barbieri L, Eustáquio AS, Fielding EN, Carter GT, Jensen PR, Feng X, Leighton M, Koehn FE, Moore B. Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria. J Am Chem Soc. 2011 Aug 31; 133(34):13311-3. PMID: 21815669; PMCID: PMC3161154.
    103. Yang YL, Xu Y, Kersten RD, Liu WT, Meehan MJ, Moore B, Bandeira N, Dorrestein PC. Connecting chemotypes and phenotypes of cultured marine microbial assemblages by imaging mass spectrometry. Angew Chem Int Ed Engl. 2011 Jun 20; 50(26):5839-42. PMID: 21574228; PMCID: PMC3687529.
    104. Kalaitzis JA, Cheng Q, Meluzzi D, Xiang L, Izumikawa M, Dorrestein PC, Moore B. Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem. 2011 Nov 15; 19(22):6633-8. PMID: 21531566; PMCID: PMC3162089.
    105. Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore B. Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol. 2011 Jun; 77(11):3617-25. PMID: 21498757; PMCID: PMC3127629.
    106. Bernhardt P, Okino T, Winter JM, Miyanaga A, Moore B. A stereoselective vanadium-dependent chloroperoxidase in bacterial antibiotic biosynthesis. J Am Chem Soc. 2011 Mar 30; 133(12):4268-70. PMID: 21384874; PMCID: PMC3065929.
    107. Wilson MC, Nam SJ, Gulder TA, Kauffman CA, Jensen PR, Fenical W, Moore B. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J Am Chem Soc. 2011 Feb 16; 133(6):1971-7. PMID: 21247149; PMCID: PMC3091981.
    108. Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore B. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem. 2011 Jan 03; 12(1):61-4. PMID: 21154492; PMCID: PMC3088357.
    109. Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore B, Lim SK, Yoon YJ. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc. 2011 Feb 02; 133(4):976-85. PMID: 21175203; PMCID: PMC3030623.
    110. Lane AL, Moore B. A sea of biosynthesis: marine natural products meet the molecular age. Nat Prod Rep. 2011 Feb; 28(2):411-28. PMID: 21170424; PMCID: PMC3101795.
    111. Gulder TA, Moore B. Salinosporamide natural products: Potent 20?S proteasome inhibitors as promising cancer chemotherapeutics. Angew Chem Int Ed Engl. 2010 Dec 03; 49(49):9346-67. PMID: 20927786; PMCID: PMC3103133.
    112. Mahlstedt S, Fielding EN, Moore B, Walsh CT. Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. Biochemistry. 2010 Oct 26; 49(42):9021-3. PMID: 20863139; PMCID: PMC2957524.
    113. Wilson MC, Gulder TA, Mahmud T, Moore B. Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450. J Am Chem Soc. 2010 Sep 15; 132(36):12757-65. PMID: 20726561; PMCID: PMC2946249.
    114. Kale AJ, McGlinchey RP, Moore B. Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling. J Biol Chem. 2010 Oct 29; 285(44):33710-7. PMID: 20736169; PMCID: PMC2962469.
    115. Werneburg M, Busch B, He J, Richter ME, Xiang L, Moore B, Roth M, Dahse HM, Hertweck C. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc. 2010 Aug 04; 132(30):10407-13. PMID: 20662518; PMCID: PMC2925430.
    116. Cardellina JH, Moore B. Richard E. Moore (1933-2007). J Nat Prod. 2010 03 26; 73(3):301-2. PMID: 20141160.
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    117. Eustáquio AS, O'Hagan D, Moore B. Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide. J Nat Prod. 2010 Mar 26; 73(3):378-82. PMID: 20085308; PMCID: PMC2846182.
    118. Schultz AW, Lewis CA, Luzung MR, Baran PS, Moore B. Functional characterization of the cyclomarin/cyclomarazine prenyltransferase CymD directs the biosynthesis of unnatural cyclic peptides. J Nat Prod. 2010 Mar 26; 73(3):373-7. PMID: 20055491; PMCID: PMC2846197.
    119. Roberts AA, Ryan KS, Moore B, Gulder TA. Total (bio)synthesis: strategies of nature and of chemists. Top Curr Chem. 2010; 297:149-203. PMID: 21495259; PMCID: PMC3109256.
    120. Deng H, McMahon SA, Eustáquio AS, Moore B, Naismith JH, O'Hagan D. Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62). Chembiochem. 2009 Oct 12; 10(15):2455-9. PMID: 19739191; PMCID: PMC3063057.
    121. Nett M, Gulder TA, Kale AJ, Hughes CC, Moore B. Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem. 2009 Oct 08; 52(19):6163-7. PMID: 19746976; PMCID: PMC2771571.
    122. Nett M, Ikeda H, Moore B. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep. 2009 Nov; 26(11):1362-84. PMID: 19844637; PMCID: PMC3063060.
    123. Liu Y, Hazzard C, Eustáquio AS, Reynolds KA, Moore B. Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity. J Am Chem Soc. 2009 Aug 05; 131(30):10376-7. PMID: 19601645; PMCID: PMC2737082.
    124. Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore B. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12295-300. PMID: 19590008; PMCID: PMC2718359.
    125. Liu WT, Ng J, Meluzzi D, Bandeira N, Gutierrez M, Simmons TL, Schultz AW, Linington RG, Moore B, Gerwick WH, Pevzner PA, Dorrestein PC. Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem. 2009 Jun 01; 81(11):4200-9. PMID: 19413302; PMCID: PMC2765223.
    126. Gulder TA, Moore B. Chasing the treasures of the sea - bacterial marine natural products. Curr Opin Microbiol. 2009 Jun; 12(3):252-60. PMID: 19481972; PMCID: PMC2695832.
    127. Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B, Lapidus A, Podell S, Allen EE, Moore B, Jensen PR. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J. 2009 Oct; 3(10):1193-203. PMID: 19474814; PMCID: PMC2749086.
    128. Winter JM, Moore B. Exploring the chemistry and biology of vanadium-dependent haloperoxidases. J Biol Chem. 2009 Jul 10; 284(28):18577-81. PMID: 19363038; PMCID: PMC2707250.
    129. Kalaitzis JA, Cheng Q, Thomas PM, Kelleher NL, Moore B. In vitro biosynthesis of unnatural enterocin and wailupemycin polyketides. J Nat Prod. 2009 Mar 27; 72(3):469-72. PMID: 19215142; PMCID: PMC2765504.
    130. Ryan KS, Moore B. Alkaloid biosynthesis takes root. Nat Chem Biol. 2009 Mar; 5(3):140-1. PMID: 19219013.
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    131. Winter JM, Jansma AL, Handel TM, Moore B. Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angew Chem Int Ed Engl. 2009; 48(4):767-70. PMID: 19072974; PMCID: PMC3517086.
    132. Eustáquio AS, Härle J, Noel JP, Moore B. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem. 2008 Sep 22; 9(14):2215-9. PMID: 18720493; PMCID: PMC2692205.
    133. Worthington AS, Hur GH, Meier JL, Cheng Q, Moore B, Burkart MD. Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem. 2008 Sep 01; 9(13):2096-103. PMID: 18666307; PMCID: PMC2994244.
    134. Moore B, Eustáquio AS, McGlinchey RP. Advances in and applications of proteasome inhibitors. Curr Opin Chem Biol. 2008 Aug; 12(4):434-40. PMID: 18656549; PMCID: PMC2560982.
    135. McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore B. Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc. 2008 Jun 25; 130(25):7822-3. PMID: 18512922; PMCID: PMC2814216.
    136. Schultz AW, Oh DC, Carney JR, Williamson RT, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore B. Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J Am Chem Soc. 2008 Apr 02; 130(13):4507-16. PMID: 18331040.
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    137. McGlinchey RP, Nett M, Moore B. Unraveling the biosynthesis of the sporolide cyclohexenone building block. J Am Chem Soc. 2008 Feb 27; 130(8):2406-7. PMID: 18232689.
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    138. Eustáquio AS, Moore B. Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angew Chem Int Ed Engl. 2008; 47(21):3936-8. PMID: 18407559.
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    139. Moore B. Extending the biosynthetic repertoire in ribosomal peptide assembly. Angew Chem Int Ed Engl. 2008; 47(49):9386-8. PMID: 18846537.
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    140. Eustáquio AS, Pojer F, Noel JP, Moore B. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nat Chem Biol. 2008 Jan; 4(1):69-74. PMID: 18059261; PMCID: PMC2762381.
    141. Cheng Q, Xiang L, Izumikawa M, Meluzzi D, Moore B. Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol. 2007 Sep; 3(9):557-8. PMID: 17704772.
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    142. Udwary DW, Zeigler L, Asolkar RN, Singan V, Lapidus A, Fenical W, Jensen PR, Moore B. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10376-81. PMID: 17563368; PMCID: PMC1965521.
    143. Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore B. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem. 2007 Jun 01; 282(22):16362-8. PMID: 17392281.
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    144. Beer LL, Moore B. Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Org Lett. 2007 Mar 01; 9(5):845-8. PMID: 17274624.
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    145. Moffitt MC, Louie GV, Bowman ME, Pence J, Noel JP, Moore B. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry. 2007 Jan 30; 46(4):1004-12. PMID: 17240984; PMCID: PMC2586389.
    146. Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore B, Noel JP. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chem Biol. 2006 Dec; 13(12):1327-38. PMID: 17185228; PMCID: PMC2859959.
    147. Song L, Barona-Gomez F, Corre C, Xiang L, Udwary DW, Austin MB, Noel JP, Moore B, Challis GL. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J Am Chem Soc. 2006 Nov 22; 128(46):14754-5. PMID: 17105255; PMCID: PMC2859292.
    148. Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore B, Kay RR, Noel JP. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol. 2006 Sep; 2(9):494-502. PMID: 16906151; PMCID: PMC2864586.
    149. Moore B. Biosynthesis of marine natural products: macroorganisms (Part B). Nat Prod Rep. 2006 Aug; 23(4):615-29. PMID: 16874392.
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    150. Hicks LM, Moffitt MC, Beer LL, Moore B, Kelleher NL. Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. ACS Chem Biol. 2006 Mar 17; 1(2):93-102. PMID: 17163649.
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    151. Izumikawa M, Cheng Q, Moore B. Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism. J Am Chem Soc. 2006 Feb 08; 128(5):1428-9. PMID: 16448095; PMCID: PMC2531066.
    152. Moore B. Biosynthesis of marine natural products: microorganisms (Part A). Nat Prod Rep. 2005 Oct; 22(5):580-93. PMID: 16193157.
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    153. Xiang L, Moore B. Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. J Bacteriol. 2005 Jun; 187(12):4286-9. PMID: 15937191; PMCID: PMC1151709.
    154. Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore B, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem. 2005 Mar 25; 280(12):11599-607. PMID: 15659395.
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    155. Moore B, Kalaitzis JA, Xiang L. Exploiting marine actinomycete biosynthetic pathways for drug discovery. Antonie Van Leeuwenhoek. 2005 Jan; 87(1):49-57. PMID: 15726291.
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    156. Xiang L, Kalaitzis JA, Moore B. EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15609-14. PMID: 15505225; PMCID: PMC524846.
    157. Garcia-Bernardo J, Xiang L, Hong H, Moore B, Leadlay PF. Engineered biosynthesis of phenyl-substituted polyketides. Chembiochem. 2004 Aug 06; 5(8):1129-31. PMID: 15300838.
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    158. Kalaitzis JA, Moore B. Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. J Nat Prod. 2004 Aug; 67(8):1419-22. PMID: 15332868.
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    159. Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore B, Noel JP. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. J Biol Chem. 2004 Oct 22; 279(43):45162-74. PMID: 15265863.
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    160. Hertweck C, Xiang L, Kalaitzis JA, Cheng Q, Palzer M, Moore B. Context-dependent behavior of the enterocin iterative polyketide synthase; a new model for ketoreduction. Chem Biol. 2004 Apr; 11(4):461-8. PMID: 15123240.
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    161. Becker JE, Moore RE, Moore B. Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. Gene. 2004 Jan 21; 325:35-42. PMID: 14697508.
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    162. Kalaitzis JA, Hamano Y, Nilsen G, Moore B. Biosynthesis and structural revision of neomarinone. Org Lett. 2003 Nov 13; 5(23):4449-52. PMID: 14602022.
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    163. Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore B. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). J Ind Microbiol Biotechnol. 2003 Aug; 30(8):510-5. PMID: 12905073.
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    164. Kalaitzis JA, Izumikawa M, Xiang L, Hertweck C, Moore B. Mutasynthesis of enterocin and wailupemycin analogues. J Am Chem Soc. 2003 Aug 06; 125(31):9290-1. PMID: 12889947.
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    165. Hoffmann D, Hevel JM, Moore RE, Moore B. Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224. Gene. 2003 Jun 05; 311:171-80. PMID: 12853152.
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    166. Xiang L, Moore B. Characterization of benzoyl coenzyme A biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus". J Bacteriol. 2003 Jan; 185(2):399-404. PMID: 12511484; PMCID: PMC145315.
    167. Moore B, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel JP. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. J Nat Prod. 2002 Dec; 65(12):1956-62. PMID: 12502351.
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    168. Hentschel U, Hopke J, Horn M, Friedrich AB, Wagner M, Hacker J, Moore B. Molecular evidence for a uniform microbial community in sponges from different oceans. Appl Environ Microbiol. 2002 Sep; 68(9):4431-40. PMID: 12200297; PMCID: PMC124103.
    169. Xiang L, Moore B. Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene. J Biol Chem. 2002 Sep 06; 277(36):32505-9. PMID: 12082112.
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    170. Xiang L, Kalaitzis JA, Nilsen G, Chen L, Moore B. Mutational analysis of the enterocin favorskii biosynthetic rearrangement. Org Lett. 2002 Mar 21; 4(6):957-60. PMID: 11893195.
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    171. Moore B, Hertweck C. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep. 2002 Feb; 19(1):70-99. PMID: 11902441.
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    172. Moore B, Walker K, Tornus I, Handa S, Poralla K, Floss HG. Biosynthetic Studies of omega-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid. J Org Chem. 1997 Apr 04; 62(7):2173-2185. PMID: 11671526.
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