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    James Brian Brewer

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0949
    CA La Jolla 92093
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      Other Positions
      TitleProfessor, Neurosciences
      InstitutionUniversity of California, San Diego

      Collapse Biography 
      Collapse Education and Training
      Weizmann Institute of ScienceFulbright Scholar to Israel
      Stanford UniversityMD, PhD2000Medicine / Neuro.
      Missouri StateBS1992Biology/Psychology

      Collapse Overview 
      Collapse Overview
      Dr. Brewer is a neurologist whose primary research interest is human memory. He has developed functional and structural magnetic resonance imaging (MRI) approaches to study memory processes in volunteers with healthy memory and in patients with memory impairment, such as cases caused by Alzheimer's disease (AD). Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and European regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 80,000 clinical patients. Appointed in both Radiology and Neurosciences Departments, he directs the Imaging Core for the multi-institutional Alzheimer’s Disease Cooperative Study and the UCSD Shiley-Marcos Alzheimer’s Disease Research Center, overseeing the brain imaging of all enrolled subjects.
      Dr. Brewer received his medical and research degrees at Stanford Medical School, where he developed advanced structural and functional neuroimaging approaches for the study of human memory. He obtained neurology residency training at Johns Hopkins and then joined the faculty of UCSD, where he holds a joint appointment in the departments of Radiology and Neurosciences. He is interim director of the Shiley-Marcos Alzheimer’s Disease Research Center and directs the Imaging Core for multiple Alzheimer’s disease clinical trials.

      Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and international regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 100,000 clinical patients.

      Collapse Research 
      Collapse Research Activities and Funding
      Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials
      NIH/NIA R01AG048252Sep 1, 2015 - Apr 30, 2020
      Role: Principal Investigator
      Sharing Clinical and Imaging Data from ADCS Clinical Trials through BIRN
      NIH/NIA R01AG034062Sep 1, 2011 - Aug 31, 2015
      Role: Principal Investigator
      Multimodal MRI Studies of Brain Structure and Function in PDD and AD
      NIH/NINDS K02NS067427Dec 1, 2009 - Nov 30, 2014
      Role: Principal Investigator
      MRI Studies of MTL Structure and Function in MCI and AD
      NIH/NINDS K23NS050305Dec 15, 2004 - Dec 31, 2009
      Role: Principal Investigator
      UCSD Alzheimer's Disease Research Center P50
      NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Cross K, Loi RQ, Balachandra AR, Meloy MJ, Wierenga CE, Galasko D, Brewer J, Dale AM, McEvoy LK. Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease. Alzheimers Res Ther. 2017 Aug 02; 9(1):55. PMID: 28764771.
        View in: PubMed
      2. Seibert TM, Karunamuni R, Kaifi S, Burkeen J, Connor M, Krishnan AP, White NS, Farid N, Bartsch H, Murzin V, Nguyen TT, Moiseenko V, Brewer J, McDonald CR, Dale AM, Hattangadi-Gluth JA. Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy. Int J Radiat Oncol Biol Phys. 2017 Apr 01; 97(5):910-918. PMID: 28333012.
        View in: PubMed
      3. Seibert TM, Karunamuni R, Bartsch H, Kaifi S, Krishnan AP, Dalia Y, Burkeen J, Murzin V, Moiseenko V, Kuperman J, White NS, Brewer J, Farid N, McDonald CR, Hattangadi-Gluth JA. Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2017 Feb 01; 97(2):263-269. PMID: 28068234.
        View in: PubMed
      4. Karunamuni R, Bartsch H, White NS, Moiseenko V, Carmona R, Marshall DC, Seibert TM, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell L, Brewer J, Dale AM, Hattangadi-Gluth JA. Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2016 Feb 01; 94(2):297-304. PMID: 26853338; PMCID: PMC4747044 [Available on 02/01/17].
      5. Rafii MS, Wishnek H, Brewer J, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. PMID: 26441570; PMCID: PMC4568340.
      6. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer J, Rissman RA, Raman R, Aisen PS. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. PMID: 26362286; PMCID: PMC4626244.
      7. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer J, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742; PMCID: PMC4677995.
      8. Reas ET, Brewer J. Mean signal and response time influences on multivoxel signals of contextual retrieval in the medial temporal lobe. Brain Behav. 2015 Feb; 5(2):e00302. PMID: 25646149; PMCID: PMC4312925.
      9. Brezova V, Moen KG, Skandsen T, Vik A, Brewer J, Salvesen O, Håberg AK. Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury. Neuroimage Clin. 2014; 5:128-40. PMID: 25068105; PMCID: PMC4110353.
      10. Gimbel SI, Brewer J. Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity. PLoS One. 2014; 9(2):e89037. PMID: 24586492; PMCID: PMC3929625.
      11. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer J, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-ß-associated neurodegeneration. JAMA Neurol. 2014 Feb; 71(2):180-7. PMID: 24378367; PMCID: PMC4118752.
      12. Rafii MS, Taylor CS, Kim HT, Desikan RS, Fleisher AS, Katibian D, Brewer J, Dale AM, Aisen PS. Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 Mar; 29(2):159-65. PMID: 24164929.
        View in: PubMed
      13. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer J, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aß-associated Alzheimer's neurodegeneration. Mol Neurodegener. 2013 Oct 02; 8:39. PMID: 24088526; PMCID: PMC3850652.
      14. Reas ET, Brewer J. Effortful retrieval reduces hippocampal activity and impairs incidental encoding. Hippocampus. 2013 May; 23(5):367-79. PMID: 23378272; PMCID: PMC4049294.
      15. Reas ET, Gimbel SI, Hales JB, Brewer J. Erratum: search-related suppression of hippocampus and default network activity during associative memory retrieval. Front Hum Neurosci. 2013; 7:2. PMID: 23355818; PMCID: PMC3553375.
      16. Reas ET, Brewer J. Retrieval search and strength evoke dissociable brain activity during episodic memory recall. J Cogn Neurosci. 2013 Feb; 25(2):219-33. PMID: 23190328; PMCID: PMC4091972.
      17. Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer J, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247; PMCID: PMC3423526.
      18. McEvoy LK, Brewer J. Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough. Imaging Med. 2012 Jun; 4(3):343-357. PMID: 23420460.
        View in: PubMed
      19. Murphy EA, Roddey JC, McEvoy LK, Holland D, Hagler DJ, Dale AM, Brewer J. CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner. Brain Imaging Behav. 2012 Mar; 6(1):16-26. PMID: 21892657; PMCID: PMC4305449.
      20. Seibert TM, Murphy EA, Kaestner EJ, Brewer J. Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging. Radiology. 2012 Apr; 263(1):226-34. PMID: 22371611; PMCID: PMC3309803.
      21. Reas ET, Gimbel SI, Hales JB, Brewer J. Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval. Front Hum Neurosci. 2011; 5:112. PMID: 22046159; PMCID: PMC3202230.
      22. Seibert TM, Majid DS, Aron AR, Corey-Bloom J, Brewer J. Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease. Neuroimage. 2012 Feb 01; 59(3):2452-63. PMID: 21945695; PMCID: PMC3254727.
      23. Seibert TM, Brewer J. Default network correlations analyzed on native surfaces. J Neurosci Methods. 2011 Jun 15; 198(2):301-11. PMID: 21514321; PMCID: PMC3111080.
      24. McEvoy LK, Holland D, Hagler DJ, Fennema-Notestine C, Brewer J, Dale AM. Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis. Radiology. 2011 Jun; 259(3):834-43. PMID: 21471273; PMCID: PMC3099042.
      25. Gimbel SI, Brewer J. Reaction time, memory strength, and fMRI activity during memory retrieval: Hippocampus and default network are differentially responsive during recollection and familiarity judgments. Cogn Neurosci. 2011 Mar; 2(1):19-23. PMID: 21278912.
        View in: PubMed
      26. Seibert TM, Hagler DJ, Brewer J. Early parietal response in episodic retrieval revealed with MEG. Hum Brain Mapp. 2011 Feb; 32(2):171-81. PMID: 20623759; PMCID: PMC3107600.
      27. Seibert TM, Gimbel SI, Hagler DJ, Brewer J. Parietal activity in episodic retrieval measured by fMRI and MEG. Neuroimage. 2011 Mar 15; 55(2):788-93. PMID: 21134473; PMCID: PMC3035726.
      28. Rafii MS, Brewer J. Functional brain imaging in the clinical assessment of consciousness. PLoS Biol. 2010 Nov 30; 8(11):e1000548. PMID: 21151340; PMCID: PMC2994656.
      29. McEvoy LK, Brewer J. Quantitative structural MRI for early detection of Alzheimer's disease. Expert Rev Neurother. 2010 Nov; 10(11):1675-88. PMID: 20977326; PMCID: PMC3182103.
      30. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer J, Hoh CK, Dale AM. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. PMID: 20720076; PMCID: PMC2923729.
      31. McEvoy LK, Edland SD, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer J, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184; PMCID: PMC2929320.
      32. Israel SL, Seibert TM, Black ML, Brewer J. Going their separate ways: dissociation of hippocampal and dorsolateral prefrontal activation during episodic retrieval and post-retrieval processing. J Cogn Neurosci. 2010 Mar; 22(3):513-25. PMID: 19301994.
        View in: PubMed
      33. Pitts MA, Martínez A, Brewer J, Hillyard SA. Early stages of figure-ground segregation during perception of the face-vase. J Cogn Neurosci. 2011 Apr; 23(4):880-95. PMID: 20146604; PMCID: PMC3071650.
      34. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer J, Dale AM. CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. J Neurosci. 2010 Feb 10; 30(6):2088-101. PMID: 20147537; PMCID: PMC2828879.
      35. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer J, Dale AM. Brain atrophy in healthy aging is related to CSF levels of Aß1-42. Cereb Cortex. 2010 Sep; 20(9):2069-79. PMID: 20051356; PMCID: PMC3025722.
      36. Holland D, Brewer J, Hagler DJ, Fennema-Notestine C, Fenema-Notestine C, Dale AM. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20954-9. PMID: 19996185.
        View in: PubMed
      37. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer J, Dale AM. One-year brain atrophy evident in healthy aging. J Neurosci. 2009 Dec 02; 29(48):15223-31. PMID: 19955375; PMCID: PMC2827793.
      38. Kovacevic S, Rafii MS, Brewer J. High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):139-45. PMID: 19474571; PMCID: PMC2688740.
      39. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer J, Dale AM. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. PMID: 19201945; PMCID: PMC2663582.
      40. Brewer J. Fully-automated volumetric MRI with normative ranges: translation to clinical practice. Behav Neurol. 2009; 21(1):21-8. PMID: 19847042.
        View in: PubMed
      41. Fleisher AS, Donohue M, Chen K, Brewer J, Aisen PS. Applications of neuroimaging to disease-modification trials in Alzheimer's disease. Behav Neurol. 2009; 21(1):129-36. PMID: 19847051.
        View in: PubMed
      42. Brewer J, Magda S, Airriess C, Smith ME. Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):578-80. PMID: 19112065.
        View in: PubMed
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