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James Brian Brewer

Title(s)Professor, Neurosciences
SchoolHealth Sciences
Phone858-534-1237
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    Other Positions
    Title(s)Professor, Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Weizmann Institute of ScienceFulbright Scholar to Israel
    Stanford UniversityMD, PhD2000Medicine / Neuro.
    Missouri StateBS1992Biology/Psychology

    Collapse Overview 
    Collapse Overview
    Dr. Brewer is a neurologist and neuroscientist whose primary research interest is human memory. He has developed functional and structural magnetic resonance imaging (MRI) approaches to study memory processes in volunteers with healthy memory and in patients with memory impairment, such as cases caused by Alzheimer's disease (AD). Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and European regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 80,000 clinical patients. Appointed in both Radiology and Neurosciences Departments, he directs the Imaging Core for the multi-institutional Alzheimer’s Disease Cooperative Study and the UCSD Shiley-Marcos Alzheimer’s Disease Research Center, overseeing the brain imaging of all enrolled subjects.
    Dr. Brewer received his medical and research degrees at Stanford Medical School, where he developed advanced structural and functional neuroimaging approaches for the study of human memory. He obtained neurology residency training at Johns Hopkins and then joined the faculty of UCSD, where he holds a joint appointment in the departments of Radiology and Neurosciences. He is director of the Shiley-Marcos Alzheimer’s Disease Research Center and directs the Imaging Core for multiple Alzheimer’s disease clinical trials.

    Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and international regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 100,000 clinical patients.

    Collapse Research 
    Collapse Research Activities and Funding
    Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials
    NIH/NIA R01AG048252Sep 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Sharing Clinical and Imaging Data from ADCS Clinical Trials through BIRN
    NIH/NIA R01AG034062Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Multimodal MRI Studies of Brain Structure and Function in PDD and AD
    NIH/NINDS K02NS067427Dec 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    MRI Studies of MTL Structure and Function in MCI and AD
    NIH/NINDS K23NS050305Dec 15, 2004 - Dec 31, 2009
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Smirnov DS, Galasko D, Hansen LA, Edland SD, Brewer JB, Salmon DP. Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease. Neurobiol Aging. 2019 Mar; 75:169-177. PMID: 30579145.
      View in: PubMed
    2. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2018 Nov 09. PMID: 30413934.
      View in: PubMed
    3. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Wierenga CE, Galasko D, Brewer JB, Dale AM, McEvoy LK. Microstructural brain changes track cognitive decline in mild cognitive impairment. Neuroimage Clin. 2018; 20:883-891. PMID: 30290303.
      View in: PubMed
    4. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 Jul 01; 75(7):834-841. PMID: 29582053.
      View in: PubMed
    5. Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):3686-3691. PMID: 29555771.
      View in: PubMed
    6. Soria JA, Huisa BN, Edland SD, Litvan I, Peavy GM, Salmon DP, Hansen LA, Galasko DR, Brewer JB, González HM, Rissman RA. Clinical-Neuropathological Correlations of Alzheimer's Disease and Related Dementias in Latino Volunteers. J Alzheimers Dis. 2018; 66(4):1539-1548. PMID: 30412501.
      View in: PubMed
    7. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 Jan; 135(1):85-93. PMID: 29177679.
      View in: PubMed
    8. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Cross K, Loi RQ, Balachandra AR, Meloy MJ, Wierenga CE, Galasko D, Brewer JB, Dale AM, McEvoy LK. Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease. Alzheimers Res Ther. 2017 Aug 02; 9(1):55. PMID: 28764771.
      View in: PubMed
    9. Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. PMID: 28381506.
      View in: PubMed
    10. Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017 03 23; 6. PMID: 28440221.
      View in: PubMed
    11. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 03; 14(3):e1002258. PMID: 28323831.
      View in: PubMed
    12. Karunamuni RA, Seibert TM, White NS, McEvoy L, Farid N, Brewer J, Dale AM, McDonald CR, Hattangadi-Gluth JA. Abnormalities in hippocampal volume of glioma patients prior to radiotherapy. Acta Oncol. 2017 Mar; 56(3):427-430. PMID: 28156177.
      View in: PubMed
    13. Gimbel SI, Brewer JB, Maril A. I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity. Brain Res. 2017 03 01; 1658:11-24. PMID: 28073651.
      View in: PubMed
    14. Seibert TM, Karunamuni R, Kaifi S, Burkeen J, Connor M, Krishnan AP, White NS, Farid N, Bartsch H, Murzin V, Nguyen TT, Moiseenko V, Brewer JB, McDonald CR, Dale AM, Hattangadi-Gluth JA. Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):910-918. PMID: 28333012.
      View in: PubMed
    15. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. PMID: 28946567.
      View in: PubMed
    16. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. PMID: 27899424.
      View in: PubMed
    17. Seibert TM, Karunamuni R, Bartsch H, Kaifi S, Krishnan AP, Dalia Y, Burkeen J, Murzin V, Moiseenko V, Kuperman J, White NS, Brewer JB, Farid N, McDonald CR, Hattangadi-Gluth JA. Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):263-269. PMID: 28068234.
      View in: PubMed
    18. Gelmont D, Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer JB, Rissman RA, Aisen P. Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. PMID: 29067300.
      View in: PubMed
    19. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 06 01; 73(6):691-7. PMID: 27088644.
      View in: PubMed
    20. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. PMID: 28642933.
      View in: PubMed
    21. Karunamuni RA, Moore KL, Seibert TM, Li N, White NS, Bartsch H, Carmona R, Marshall D, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell LK, Brewer J, Dale AM, Moiseenko V, Hattangadi-Gluth JA. Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging. Radiother Oncol. 2016 Jan; 118(1):29-34. PMID: 26806266.
      View in: PubMed
    22. Karunamuni R, Bartsch H, White NS, Moiseenko V, Carmona R, Marshall DC, Seibert TM, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell L, Brewer JB, Dale AM, Hattangadi-Gluth JA. Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2016 Feb 01; 94(2):297-304. PMID: 26853338.
      View in: PubMed
    23. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. PMID: 26441570; PMCID: PMC4568340.
    24. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. PMID: 26362286; PMCID: PMC4626244.
    25. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217.
    26. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742.
      View in: PubMed
    27. Reas ET, Brewer JB. Mean signal and response time influences on multivoxel signals of contextual retrieval in the medial temporal lobe. Brain Behav. 2015 Feb; 5(2):e00302. PMID: 25646149; PMCID: PMC4312925.
    28. Hill DLG, Schwarz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, Maguire P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang H, Wolz R, Stephenson D. Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease. Alzheimers Dement. 2014 Jul; 10(4):421-429.e3. PMID: 24985687.
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    29. Brezova V, Moen KG, Skandsen T, Vik A, Brewer JB, Salvesen O, Håberg AK. Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury. Neuroimage Clin. 2014; 5:128-40. PMID: 25068105; PMCID: PMC4110353.
    30. Gimbel SI, Brewer JB. Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity. PLoS One. 2014; 9(2):e89037. PMID: 24586492.
      View in: PubMed
    31. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-ß-associated neurodegeneration. JAMA Neurol. 2014 Feb; 71(2):180-7. PMID: 24378367; PMCID: PMC4118752.
    32. Rafii MS, Taylor CS, Kim HT, Desikan RS, Fleisher AS, Katibian D, Brewer JB, Dale AM, Aisen PS. Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 Mar; 29(2):159-65. PMID: 24164929.
      View in: PubMed
    33. Yu P, Sun J, Wolz R, Stephenson D, Brewer J, Fox NC, Cole PE, Jack CR, Hill DL, Schwarz AJ. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging. 2014 Apr; 35(4):808-18. PMID: 24211008; PMCID: PMC4201941.
    34. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aß-associated Alzheimer's neurodegeneration. Mol Neurodegener. 2013 Oct 02; 8:39. PMID: 24088526; PMCID: PMC3850652.
    35. Reas ET, Brewer JB. Imbalance of incidental encoding across tasks: an explanation for non-memory-related hippocampal activations? J Exp Psychol Gen. 2013 Nov; 142(4):1171-9. PMID: 23773160; PMCID: PMC3834009.
    36. Reas ET, Brewer JB. Effortful retrieval reduces hippocampal activity and impairs incidental encoding. Hippocampus. 2013 May; 23(5):367-79. PMID: 23378272.
      View in: PubMed
    37. Reas ET, Gimbel SI, Hales JB, Brewer JB. Erratum: search-related suppression of hippocampus and default network activity during associative memory retrieval. Front Hum Neurosci. 2013; 7:2. PMID: 23355818.
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    38. Reas ET, Brewer JB. Retrieval search and strength evoke dissociable brain activity during episodic memory recall. J Cogn Neurosci. 2013 Feb; 25(2):219-33. PMID: 23190328.
      View in: PubMed
    39. Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247.
      View in: PubMed
    40. McEvoy LK, Brewer JB. Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough. Imaging Med. 2012 Jun; 4(3):343-357. PMID: 23420460.
      View in: PubMed
    41. Hales JB, Brewer JB. The path to memory is guided by strategy: distinct networks are engaged in associative encoding under visual and verbal strategy and influence memory performance in healthy and impaired individuals. J Cogn Neurosci. 2012 Jun; 24(6):1398-410. PMID: 22390467.
      View in: PubMed
    42. Murphy EA, Roddey JC, McEvoy LK, Holland D, Hagler DJ, Dale AM, Brewer JB. CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner. Brain Imaging Behav. 2012 Mar; 6(1):16-26. PMID: 21892657; PMCID: PMC4305449.
    43. Seibert TM, Murphy EA, Kaestner EJ, Brewer JB. Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging. Radiology. 2012 Apr; 263(1):226-34. PMID: 22371611; PMCID: PMC3309803.
    44. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM, Weiner M, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, Green RC, Saykin AJ, Morris J, Liu E, Montine T, Gamst A, Thomas RG, Donohue M, Walter S, Gessert D, Sather T, Harvey D, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe RA, Foster N, Reiman EM, Chen K, Mathis C, Cairns NJ, Taylor-Reinwald L, Trojanowki JQ, Shaw L, Lee VM, Korecka M, Crawford K, Neu S, Foroud TM, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder PJ, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider LS, Pawluczyk S, Spann BM, Brewer J, Vanderswag H, Heidebrink JL, Lord JL, Johnson K, Doody RS, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig LS, Bell KL, Morris JC, Ances B, Carroll M, Leon S, Mintun MA, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah RC, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon MJ, Glodzik L, De Santi S, Doraiswamy PM, Petrella JR, Coleman RE, Arnold SE, Karlawish JH, Wolk D, Smith CD, Jicha G, Hardy P, Lopez OL, Oakley M, Simpson DM, Porsteinsson AP, Goldstein BS, Martin K, Makino KM, Ismail MS, Brand C, Mulnard RA, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey AI, Lah JJ, Cellar JS, Burns JM, Anderson HS, Swerdlow RH, Apostolova L, Lu PH, Bartzokis G, Silverman DH, Graff-Radford NR, Parfitt F, Johnson H, Farlow MR, Hake AM, Matthews BR, Herring S, van Dyck CH, Carson RE, MacAvoy MG, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung R, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam MM, Lipowski K, Wu CK, Johnson N, Sadowsky C, Martinez W, Villena T, Turner RS, Johnson K, Reynolds B, Sperling RA, Johnson KA, Marshall G, Frey M, Yesavage J, Taylor JL, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson AE, Norbash A, Johnson PL, Obisesan TO, Wolday S, Bwayo SK, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, Kittur S, Borrie M, Lee TY, Bartha R, Johnson S, Asthana S, Carlsson CM, Potkin SG, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre DW, Kataki M, Zimmerman EA, Celmins D, Brown AD, Pearlson GD, Blank K, Anderson K, Santulli RB, Schwartz ES, Sink KM, Williamson JD, Garg P, Watkins F, Ott BR, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen HJ, Miller BL, Mintzer J, Longmire CF, Spicer K, Finger E, Rachinsky I, Drost D, Jernigan T, McCabe C, Grant E, Ernst T, Kuperman J, Chung Y, Murray S, Bloss C, Darst B, Pritchett L, Saito A, Amaral D, DiNino M, Eyngorina B, Sowell E, Houston S, Soderberg L, Kaufmann W, van Zijl P, Rizzo-Busack H, Javid M, Mehta N, Ruberry E, Powers A, Rosen B, Gebhard N, Manigan H, Frazier J, Kennedy D, Yakutis L, Hill M, Gruen J, Bosson-Heenan J, Carlson H. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. PMID: 22343285.
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    45. Reas ET, Gimbel SI, Hales JB, Brewer JB. Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval. Front Hum Neurosci. 2011; 5:112. PMID: 22046159; PMCID: PMC3202230.
    46. Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM. Amyloid-ß associated volume loss occurs only in the presence of phospho-tau. Ann Neurol. 2011 Oct; 70(4):657-61. PMID: 22002658; PMCID: PMC3368003.
    47. Seibert TM, Majid DS, Aron AR, Corey-Bloom J, Brewer JB. Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease. Neuroimage. 2012 Feb 01; 59(3):2452-63. PMID: 21945695; PMCID: PMC3254727.
    48. Seibert TM, Brewer JB. Default network correlations analyzed on native surfaces. J Neurosci Methods. 2011 Jun 15; 198(2):301-11. PMID: 21514321; PMCID: PMC3111080.
    49. McEvoy LK, Holland D, Hagler DJ, Fennema-Notestine C, Brewer JB, Dale AM. Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis. Radiology. 2011 Jun; 259(3):834-43. PMID: 21471273; PMCID: PMC3099042.
    50. Gimbel SI, Brewer JB. Reaction time, memory strength, and fMRI activity during memory retrieval: Hippocampus and default network are differentially responsive during recollection and familiarity judgments. Cogn Neurosci. 2011 Mar; 2(1):19-23. PMID: 21278912.
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    51. Seibert TM, Hagler DJ, Brewer JB. Early parietal response in episodic retrieval revealed with MEG. Hum Brain Mapp. 2011 Feb; 32(2):171-81. PMID: 20623759; PMCID: PMC3107600.
    52. Seibert TM, Gimbel SI, Hagler DJ, Brewer JB. Parietal activity in episodic retrieval measured by fMRI and MEG. Neuroimage. 2011 Mar 15; 55(2):788-93. PMID: 21134473; PMCID: PMC3035726.
    53. Rafii MS, Brewer JB. Functional brain imaging in the clinical assessment of consciousness. PLoS Biol. 2010 Nov 30; 8(11):e1000548. PMID: 21151340; PMCID: PMC2994656.
    54. McEvoy LK, Brewer JB. Quantitative structural MRI for early detection of Alzheimer's disease. Expert Rev Neurother. 2010 Nov; 10(11):1675-88. PMID: 20977326; PMCID: PMC3182103.
    55. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer JB, Hoh CK, Dale AM. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. PMID: 20720076; PMCID: PMC2923729.
    56. McEvoy LK, Edland SD, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer JB, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184; PMCID: PMC2929320.
    57. Israel SL, Seibert TM, Black ML, Brewer JB. Going their separate ways: dissociation of hippocampal and dorsolateral prefrontal activation during episodic retrieval and post-retrieval processing. J Cogn Neurosci. 2010 Mar; 22(3):513-25. PMID: 19301994.
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