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James Brian Brewer

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentRadiology
Address9500 Gilman Drive #0949
La Jolla CA 92093
Phone858-534-1237
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    Other Positions
    TitleProfessor, Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Weizmann Institute of ScienceFulbright Scholar to Israel
    Stanford UniversityMD, PhD2000Medicine / Neuro.
    Missouri StateBS1992Biology/Psychology

    Collapse Overview 
    Collapse Overview
    Dr. Brewer is a neurologist whose primary research interest is human memory. He has developed functional and structural magnetic resonance imaging (MRI) approaches to study memory processes in volunteers with healthy memory and in patients with memory impairment, such as cases caused by Alzheimer's disease (AD). Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and European regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 80,000 clinical patients. Appointed in both Radiology and Neurosciences Departments, he directs the Imaging Core for the multi-institutional Alzheimer’s Disease Cooperative Study and the UCSD Shiley-Marcos Alzheimer’s Disease Research Center, overseeing the brain imaging of all enrolled subjects.
    Dr. Brewer received his medical and research degrees at Stanford Medical School, where he developed advanced structural and functional neuroimaging approaches for the study of human memory. He obtained neurology residency training at Johns Hopkins and then joined the faculty of UCSD, where he holds a joint appointment in the departments of Radiology and Neurosciences. He is interim director of the Shiley-Marcos Alzheimer’s Disease Research Center and directs the Imaging Core for multiple Alzheimer’s disease clinical trials.

    Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and international regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over 100,000 clinical patients.


    Collapse Research 
    Collapse Research Activities and Funding
    Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials
    NIH/NIA R01AG048252Sep 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Sharing Clinical and Imaging Data from ADCS Clinical Trials through BIRN
    NIH/NIA R01AG034062Sep 1, 2011 - Aug 31, 2015
    Role: Principal Investigator
    Multimodal MRI Studies of Brain Structure and Function in PDD and AD
    NIH/NINDS K02NS067427Dec 1, 2009 - Nov 30, 2014
    Role: Principal Investigator
    MRI Studies of MTL Structure and Function in MCI and AD
    NIH/NINDS K23NS050305Dec 15, 2004 - Dec 31, 2009
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH/NIA P50AG005131Sep 28, 1984 - Mar 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer J, Rissman RA, Siffert J, Aisen PS. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 Mar 26. PMID: 29582053.
      View in: PubMed
    2. Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer J, Brewerton S, Biggs WH, Turpaz Y, Venter JC. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018 Apr 03; 115(14):3686-3691. PMID: 29555771.
      View in: PubMed
    3. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer J, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 Jan; 135(1):85-93. PMID: 29177679.
      View in: PubMed
    4. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Cross K, Loi RQ, Balachandra AR, Meloy MJ, Wierenga CE, Galasko D, Brewer J, Dale AM, McEvoy LK. Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease. Alzheimers Res Ther. 2017 Aug 02; 9(1):55. PMID: 28764771.
      View in: PubMed
    5. Relkin NR, Thomas RG, Rissman RA, Brewer J, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. PMID: 28381506.
      View in: PubMed
    6. Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017 03 23; 6. PMID: 28440221.
      View in: PubMed
    7. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer J, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258. PMID: 28323831.
      View in: PubMed
    8. Karunamuni RA, Seibert TM, White NS, McEvoy L, Farid N, Brewer J, Dale AM, McDonald CR, Hattangadi-Gluth JA. Abnormalities in hippocampal volume of glioma patients prior to radiotherapy. Acta Oncol. 2017 Mar; 56(3):427-430. PMID: 28156177.
      View in: PubMed
    9. Gimbel SI, Brewer J, Maril A. I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity. Brain Res. 2017 03 01; 1658:11-24. PMID: 28073651.
      View in: PubMed
    10. Seibert TM, Karunamuni R, Kaifi S, Burkeen J, Connor M, Krishnan AP, White NS, Farid N, Bartsch H, Murzin V, Nguyen TT, Moiseenko V, Brewer J, McDonald CR, Dale AM, Hattangadi-Gluth JA. Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):910-918. PMID: 28333012.
      View in: PubMed
    11. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. PMID: 28946567.
      View in: PubMed
    12. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer J. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. PMID: 27899424.
      View in: PubMed
    13. Seibert TM, Karunamuni R, Bartsch H, Kaifi S, Krishnan AP, Dalia Y, Burkeen J, Murzin V, Moiseenko V, Kuperman J, White NS, Brewer J, Farid N, McDonald CR, Hattangadi-Gluth JA. Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging. Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):263-269. PMID: 28068234.
      View in: PubMed
    14. Gelmont D, Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer J, Rissman RA, Aisen P. Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. PMID: 29067300.
      View in: PubMed
    15. Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer J, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. JAMA Neurol. 2016 Jun 01; 73(6):691-7. PMID: 27088644.
      View in: PubMed
    16. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. PMID: 28642933.
      View in: PubMed
    17. Karunamuni RA, Moore KL, Seibert TM, Li N, White NS, Bartsch H, Carmona R, Marshall D, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell LK, Brewer J, Dale AM, Moiseenko V, Hattangadi-Gluth JA. Radiation sparing of cerebral cortex in brain tumor patients using quantitative neuroimaging. Radiother Oncol. 2016 Jan; 118(1):29-34. PMID: 26806266.
      View in: PubMed
    18. Karunamuni R, Bartsch H, White NS, Moiseenko V, Carmona R, Marshall DC, Seibert TM, McDonald CR, Farid N, Krishnan A, Kuperman J, Mell L, Brewer J, Dale AM, Hattangadi-Gluth JA. Dose-Dependent Cortical Thinning After Partial Brain Irradiation in High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2016 Feb 01; 94(2):297-304. PMID: 26853338.
      View in: PubMed
    19. Rafii MS, Wishnek H, Brewer J, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. PMID: 26441570; PMCID: PMC4568340.
    20. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer J, Rissman RA, Raman R, Aisen PS. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. PMID: 26362286; PMCID: PMC4626244.
    21. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217.
    22. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer J, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. PMID: 25862742.
      View in: PubMed
    23. Reas ET, Brewer J. Mean signal and response time influences on multivoxel signals of contextual retrieval in the medial temporal lobe. Brain Behav. 2015 Feb; 5(2):e00302. PMID: 25646149; PMCID: PMC4312925.
    24. Hill DL, Schwarz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, Maguire P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang H, Wolz R, Stephenson D. Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease. Alzheimers Dement. 2014 Jul; 10(4):421-9.e3. PMID: 24985687.
      View in: PubMed
    25. Brezova V, Moen KG, Skandsen T, Vik A, Brewer J, Salvesen O, Håberg AK. Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury. Neuroimage Clin. 2014; 5:128-40. PMID: 25068105; PMCID: PMC4110353.
    26. Gimbel SI, Brewer J. Elaboration versus suppression of cued memories: influence of memory recall instruction and success on parietal lobe, default network, and hippocampal activity. PLoS One. 2014; 9(2):e89037. PMID: 24586492.
      View in: PubMed
    27. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer J, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-ß-associated neurodegeneration. JAMA Neurol. 2014 Feb; 71(2):180-7. PMID: 24378367; PMCID: PMC4118752.
    28. Rafii MS, Taylor CS, Kim HT, Desikan RS, Fleisher AS, Katibian D, Brewer J, Dale AM, Aisen PS. Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 Mar; 29(2):159-65. PMID: 24164929.
      View in: PubMed
    29. Yu P, Sun J, Wolz R, Stephenson D, Brewer J, Fox NC, Cole PE, Jack CR, Hill DL, Schwarz AJ. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging. 2014 Apr; 35(4):808-18. PMID: 24211008; PMCID: PMC4201941.
    30. Desikan RS, Thompson WK, Holland D, Hess CP, Brewer J, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aß-associated Alzheimer's neurodegeneration. Mol Neurodegener. 2013 Oct 02; 8:39. PMID: 24088526; PMCID: PMC3850652.
    31. Reas ET, Brewer J. Imbalance of incidental encoding across tasks: an explanation for non-memory-related hippocampal activations? J Exp Psychol Gen. 2013 Nov; 142(4):1171-9. PMID: 23773160; PMCID: PMC3834009.
    32. Reas ET, Brewer J. Effortful retrieval reduces hippocampal activity and impairs incidental encoding. Hippocampus. 2013 May; 23(5):367-79. PMID: 23378272.
      View in: PubMed
    33. Reas ET, Gimbel SI, Hales JB, Brewer J. Erratum: search-related suppression of hippocampus and default network activity during associative memory retrieval. Front Hum Neurosci. 2013; 7:2. PMID: 23355818.
      View in: PubMed
    34. Reas ET, Brewer J. Retrieval search and strength evoke dissociable brain activity during episodic memory recall. J Cogn Neurosci. 2013 Feb; 25(2):219-33. PMID: 23190328.
      View in: PubMed
    35. Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer J, Aisen PS, Sperling RA, Dale AM. Amyloid-ß--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol. 2012 Jun; 69(6):709-13. PMID: 22529247.
      View in: PubMed
    36. McEvoy LK, Brewer J. Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough. Imaging Med. 2012 Jun; 4(3):343-357. PMID: 23420460.
      View in: PubMed
    37. Hales JB, Brewer J. The path to memory is guided by strategy: distinct networks are engaged in associative encoding under visual and verbal strategy and influence memory performance in healthy and impaired individuals. J Cogn Neurosci. 2012 Jun; 24(6):1398-410. PMID: 22390467.
      View in: PubMed
    38. Murphy EA, Roddey JC, McEvoy LK, Holland D, Hagler DJ, Dale AM, Brewer J. CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner. Brain Imaging Behav. 2012 Mar; 6(1):16-26. PMID: 21892657; PMCID: PMC4305449.
    39. Seibert TM, Murphy EA, Kaestner EJ, Brewer J. Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging. Radiology. 2012 Apr; 263(1):226-34. PMID: 22371611; PMCID: PMC3309803.
    40. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. PMID: 22343285.
      View in: PubMed
    41. Reas ET, Gimbel SI, Hales JB, Brewer J. Search-Related Suppression of Hippocampus and Default Network Activity during Associative Memory Retrieval. Front Hum Neurosci. 2011; 5:112. PMID: 22046159; PMCID: PMC3202230.
    42. Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer J, Hyman BT, Dale AM. Amyloid-ß associated volume loss occurs only in the presence of phospho-tau. Ann Neurol. 2011 Oct; 70(4):657-61. PMID: 22002658; PMCID: PMC3368003.
    43. Seibert TM, Majid DS, Aron AR, Corey-Bloom J, Brewer J. Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's disease. Neuroimage. 2012 Feb 01; 59(3):2452-63. PMID: 21945695; PMCID: PMC3254727.
    44. Seibert TM, Brewer J. Default network correlations analyzed on native surfaces. J Neurosci Methods. 2011 Jun 15; 198(2):301-11. PMID: 21514321; PMCID: PMC3111080.
    45. McEvoy LK, Holland D, Hagler DJ, Fennema-Notestine C, Brewer J, Dale AM. Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis. Radiology. 2011 Jun; 259(3):834-43. PMID: 21471273; PMCID: PMC3099042.
    46. Gimbel SI, Brewer J. Reaction time, memory strength, and fMRI activity during memory retrieval: Hippocampus and default network are differentially responsive during recollection and familiarity judgments. Cogn Neurosci. 2011 Mar; 2(1):19-23. PMID: 21278912.
      View in: PubMed
    47. Seibert TM, Hagler DJ, Brewer J. Early parietal response in episodic retrieval revealed with MEG. Hum Brain Mapp. 2011 Feb; 32(2):171-81. PMID: 20623759; PMCID: PMC3107600.
    48. Seibert TM, Gimbel SI, Hagler DJ, Brewer J. Parietal activity in episodic retrieval measured by fMRI and MEG. Neuroimage. 2011 Mar 15; 55(2):788-93. PMID: 21134473; PMCID: PMC3035726.
    49. Rafii MS, Brewer J. Functional brain imaging in the clinical assessment of consciousness. PLoS Biol. 2010 Nov 30; 8(11):e1000548. PMID: 21151340; PMCID: PMC2994656.
    50. McEvoy LK, Brewer J. Quantitative structural MRI for early detection of Alzheimer's disease. Expert Rev Neurother. 2010 Nov; 10(11):1675-88. PMID: 20977326; PMCID: PMC3182103.
    51. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer J, Hoh CK, Dale AM. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. PMID: 20720076; PMCID: PMC2923729.
    52. McEvoy LK, Edland SD, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer J, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184; PMCID: PMC2929320.
    53. Israel SL, Seibert TM, Black ML, Brewer J. Going their separate ways: dissociation of hippocampal and dorsolateral prefrontal activation during episodic retrieval and post-retrieval processing. J Cogn Neurosci. 2010 Mar; 22(3):513-25. PMID: 19301994.
      View in: PubMed
    54. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer J, Dale AM. CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. J Neurosci. 2010 Feb 10; 30(6):2088-101. PMID: 20147537; PMCID: PMC2828879.
    55. Pitts MA, Martínez A, Brewer J, Hillyard SA. Early stages of figure-ground segregation during perception of the face-vase. J Cogn Neurosci. 2011 Apr; 23(4):880-95. PMID: 20146604; PMCID: PMC3071650.
    56. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer J, Dale AM. Brain atrophy in healthy aging is related to CSF levels of Aß1-42. Cereb Cortex. 2010 Sep; 20(9):2069-79. PMID: 20051356; PMCID: PMC3025722.
    57. Holland D, Brewer J, Hagler DJ, Fennema-Notestine C, Fenema-Notestine C, Dale AM. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20954-9. PMID: 19996185.
      View in: PubMed
    58. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer J, Dale AM. One-year brain atrophy evident in healthy aging. J Neurosci. 2009 Dec 02; 29(48):15223-31. PMID: 19955375; PMCID: PMC2827793.
    59. Hales JB, Israel SL, Swann NC, Brewer J. Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates. J Cogn Neurosci. 2009 Jul; 21(7):1244-54. PMID: 18752401; PMCID: PMC2674124.
    60. Kovacevic S, Rafii MS, Brewer J. High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):139-45. PMID: 19474571; PMCID: PMC2688740.
    61. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer J, Dale AM. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. PMID: 19201945; PMCID: PMC2663582.
    62. Brewer J. Fully-automated volumetric MRI with normative ranges: translation to clinical practice. Behav Neurol. 2009; 21(1):21-8. PMID: 19847042.
      View in: PubMed
    63. Fleisher AS, Donohue M, Chen K, Brewer J, Aisen PS. Applications of neuroimaging to disease-modification trials in Alzheimer's disease. Behav Neurol. 2009; 21(1):129-36. PMID: 19847051.
      View in: PubMed
    64. Brewer J, Magda S, Airriess C, Smith ME. Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):578-80. PMID: 19112065.
      View in: PubMed
    65. Gold JJ, Smith CN, Bayley PJ, Shrager Y, Brewer J, Stark CE, Hopkins RO, Squire LR. Item memory, source memory, and the medial temporal lobe: concordant findings from fMRI and memory-impaired patients. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9351-6. PMID: 16751272; PMCID: PMC1482613.
    66. Brewer J, Moghekar A. Imaging the medial temporal lobe: exploring new dimensions. Trends Cogn Sci. 2002 May 01; 6(5):217-223. PMID: 11983585.
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