James Brewer

Title(s)Professor, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Title(s)Professor, Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Weizmann Institute of ScienceFulbright Scholar to Israel
    Stanford UniversityMD, PhD2000Medicine / Neuro.
    Missouri StateBS1992Biology/Psychology

    Collapse Overview 
    Collapse Overview
    Dr. Brewer is a neurologist and neuroscientist whose primary research interest is human memory. Dr. Brewer has developed functional and structural magnetic resonance imaging (MRI) approaches to study memory processes in volunteers with healthy memory and in patients with memory impairment. Dr. Brewer has developed and applied advanced neuroimaging approaches for early detection of Alzheimer’s in the clinical setting and also as a measure of the efficacy of new drugs under development. He conducted studies that led to FDA and European regulatory clearance of a widely used tool for brain structure analysis that has been used to assess brain atrophy in over a million clinical patients. In addition to directing his research laboratory, Dr. Brewer directs the UCSD Shiley-Marcos Alzheimer’s Disease Research Center and directs the Imaging Core for the multi-institutional Alzheimer’s Disease Cooperative Study, overseeing the brain imaging of all enrolled subjects.

    Dr. Brewer received his medical and research degrees at Stanford Medical School, pursued neurology residency training at Johns Hopkins, and then in 2004 joined the faculty of UC San Diego. He is Professor and Chair of the Department of Neurosciences and holds a secondary appointment in the Department of Radiology.

    Collapse Research 
    Collapse Research Activities and Funding
    Multidisciplinary training in basic and translational Alzheimer's disease research
    NIH T32AG066596May 1, 2020 - Apr 30, 2025
    Role: Co-Principal Investigator
    UCSD Alzheimer's Disease Research Centers P30
    NIH P30AG062429May 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Study of Latinos Investigation of Neurocognitive Aging 2
    NIH R56AG048642Sep 1, 2015 - Apr 30, 2022
    Role: Co-Principal Investigator
    Longitudinal Cognitive ERP studies: Advancement for AD Clinical Trials
    NIH R01AG048252Sep 1, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Sharing Clinical and Imaging Data from ADCS Clinical Trials through BIRN
    NIH R01AG034062Sep 1, 2011 - May 31, 2018
    Role: Principal Investigator
    Multimodal MRI Studies of Brain Structure and Function in PDD and AD
    NIH K02NS067427Dec 1, 2009 - Nov 30, 2015
    Role: Principal Investigator
    MRI Studies of MTL Structure and Function in MCI and AD
    NIH K23NS050305Dec 15, 2004 - Dec 31, 2009
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Sep 28, 1984 - Mar 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, et al. PMID: 37461624; PMCID: PMC10350126.
      View in: PubMed   Mentions:
    2. Improved multimodal prediction of progression from MCI to Alzheimer's disease combining genetics with quantitative brain MRI and cognitive measures. Alzheimers Dement. 2023 11; 19(11):5151-5158. Reas ET, Shadrin A, Frei O, Motazedi E, McEvoy L, Bahrami S, van der Meer D, Makowski C, Loughnan R, Wang X, Broce I, Banks SJ, Fominykh V, Cheng W, Holland D, Smeland OB, Seibert T, Selbaek G, Brewer JB, Fan CC, Andreassen OA, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 37132098; PMCID: PMC10620101.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Sex differences in Alzheimer's disease: plasma MMP-9 and markers of disease severity. Alzheimers Res Ther. 2022 11 02; 14(1):160. Tsiknia AA, Sundermann EE, Reas ET, Edland SD, Brewer JB, Galasko D, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36324151; PMCID: PMC9628176.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. Alzheimer's polygenic hazard score in SuperAgers: SuperGenes or SuperResilience? Alzheimers Dement (N Y). 2022; 8(1):e12321. Spencer BE, Banks SJ, Dale AM, Brewer JB, Makowski-Woidan B, Weintraub S, Mesulam MM, Geula C, Rogalski E. PMID: 35929001; PMCID: PMC9345399.
      View in: PubMed   Mentions: 3  
    5. Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression. Mol Psychiatry. 2022 10; 27(10):4314-4322. Tsiknia AA, Edland SD, Sundermann EE, Reas ET, Brewer JB, Galasko D, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 35768637; PMCID: PMC9718670.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    6. Sex and APOE ɛ4 modify the effect of cardiovascular risk on tau in cognitively normal older adults. Brain Commun. 2022; 4(1):fcac035. Tsiknia AA, Reas E, Bangen KJ, Sundermann EE, McEvoy L, Brewer JB, Edland SD, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 35233525; PMCID: PMC8882003.
      View in: PubMed   Mentions: 5  
    7. Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer's disease: a randomized trial. Sci Rep. 2022 01 25; 12(1):1346. Kellar D, Register T, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. PMID: 35079029; PMCID: PMC8789895.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    8. Sex differences in Alzheimer's disease: do differences in tau explain the verbal memory gap? Neurobiol Aging. 2021 11; 107:70-77. Banks SJ, Andrews MJ, Digma L, Madsen J, Reas ET, Caldwell JZK, McEvoy LK, Fan CC, Dale AM, Brewer JB, Alzheimer's Disease Neuroimaging Initiative. PMID: 34399127; PMCID: PMC8963683.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    9. Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease. J Alzheimers Dis Rep. 2021 Jan 20; 5(1):41-48. Andrews M, Ross R, Malhotra A, Ancoli-Israel S, Brewer JB, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 33681715; PMCID: PMC7903001.
      View in: PubMed   Mentions: 3  
    10. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. JAMA Neurol. 2021 01 01; 78(1):102-113. Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC), Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. PMID: 33074286; PMCID: PMC7573798.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    11. Noninvasive characterization of Alzheimer's disease by circulating, cell-free messenger RNA next-generation sequencing. Sci Adv. 2020 12; 6(50). Toden S, Zhuang J, Acosta AD, Karns AP, Salathia NS, Brewer JB, Wilcock DM, Aballi J, Nerenberg M, Quake SR, Ibarra A. PMID: 33298436; PMCID: PMC7821903.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    12. Gene- and age-informed screening for preclinical Alzheimer's disease trials. Alzheimers Dement. 2021 03; 17(3):457-465. Spencer BE, Digma LA, Jennings RG, Brewer JB, Alzheimer's Disease Neuroimaging Initiative and the A4 Study Team. PMID: 33226723; PMCID: PMC8906231.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Assessment of genetic risk for improved clinical-neuropathological correlations. Acta Neuropathol Commun. 2020 09 10; 8(1):160. Spencer BE, Jennings RG, Fan CC, Brewer JB. PMID: 32912321; PMCID: PMC7488152.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology. 2020 10 20; 95(16):e2295-e2304. Weigand AJ, Bondi MW, Thomas KR, Campbell NL, Galasko DR, Salmon DP, Sewell D, Brewer JB, Feldman HH, Delano-Wood L, Alzheimer's Disease Neuroimaging Initiative. PMID: 32878992; PMCID: PMC7713781.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    15. Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA Neurol. 2020 09 01; 77(9):1099-1109. Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, Donohue MC, Brewer JB, Jenkins C, Harless K, Gessert D, Aisen PS. PMID: 32568367; PMCID: PMC7309571.
      View in: PubMed   Mentions: 117     Fields:    Translation:Humans
    16. Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research. Alzheimers Res Ther. 2020 06 30; 12(1):78. Peavy GM, Jenkins CW, Little EA, Gigliotti C, Calcetas A, Edland SD, Brewer JB, Galasko D, Salmon DP. PMID: 32605603; PMCID: PMC7325657.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tau. Brain Commun. 2020; 2(1):fcaa025. Digma LA, Madsen JR, Rissman RA, Jacobs DM, Brewer JB, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative . PMID: 32337508; PMCID: PMC7166251.
      View in: PubMed   Mentions: 32  
    18. Associations Between Microstructure, Amyloid, and Cognition in Amnestic Mild Cognitive Impairment and Dementia. J Alzheimers Dis. 2020; 73(1):347-357. Reas ET, Hagler DJ, Kuperman JM, Wierenga CE, Galasko D, White NS, Dale AM, Banks SJ, McEvoy LK, Brewer JB. PMID: 31796676; PMCID: PMC7266036.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    19. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
      View in: PubMed   Mentions: 275     Fields:    Translation:HumansCells
    20. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH, Alzheimer’s Disease Cooperative Study TCAD Study Group. PMID: 31282954; PMCID: PMC6618817.
      View in: PubMed   Mentions: 10     Fields:    
    21. High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid. Clin Chem. 2019 12; 65(12):1572-1580. Weber DM, Tran D, Goldman SM, Taylor SW, Ginns EI, Lagier RJ, Rissman RA, Brewer JB, Clarke NJ. PMID: 31628138.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. PMID: 31329216; PMCID: PMC6646979.
      View in: PubMed   Mentions: 63     Fields:    
    23. Tau and atrophy: domain-specific relationships with cognition. Alzheimers Res Ther. 2019 07 27; 11(1):65. Digma LA, Madsen JR, Reas ET, Dale AM, Brewer JB, Banks SJ, Alzheimer’s Disease Neuroimaging Initiative. PMID: 31351484; PMCID: PMC6661099.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    24. Distinct structural correlates of the dominant and nondominant languages in bilinguals with Alzheimer's disease (AD). Neuropsychologia. 2019 09; 132:107131. Smirnov DS, Stasenko A, Salmon DP, Galasko D, Brewer JB, Gollan TH. PMID: 31271821; PMCID: PMC6702045.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Combined Biomarker Prognosis of Mild Cognitive Impairment: An 11-Year Follow-Up Study in the Alzheimer's Disease Neuroimaging Initiative. J Alzheimers Dis. 2019; 68(4):1549-1559. Spencer BE, Jennings RG, Brewer JB, Alzheimer’s Disease Neuroimaging Initiative. PMID: 30958366; PMCID: PMC8906222.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Trajectories of cognitive decline differ in hippocampal sclerosis and Alzheimer's disease. Neurobiol Aging. 2019 03; 75:169-177. Smirnov DS, Galasko D, Hansen LA, Edland SD, Brewer JB, Salmon DP. PMID: 30579145; PMCID: PMC6492933.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathol. 2019 02; 137(2):209-226. Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, Mormino EC, Sperling RA, Bennett DA, McEvoy LK, Brewer JB, Feldman HH, Hyman BT, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Schellenberg GD, Yaffe K, Sugrue LP, Dale AM, Posthuma D, Andreassen OA, Karch CM, Desikan RS. PMID: 30413934; PMCID: PMC6358498.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    28. Microstructural brain changes track cognitive decline in mild cognitive impairment. Neuroimage Clin. 2018; 20:883-891. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Wierenga CE, Galasko D, Brewer JB, Dale AM, McEvoy LK. PMID: 30290303; PMCID: PMC6171091.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    29. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 07 01; 75(7):834-841. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS, AAV2-NGF Study Team. PMID: 29582053; PMCID: PMC5885277.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    30. Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):3686-3691. Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC. PMID: 29555771; PMCID: PMC5889622.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    31. Clinical-Neuropathological Correlations of Alzheimer's Disease and Related Dementias in Latino Volunteers. J Alzheimers Dis. 2018; 66(4):1539-1548. Soria JA, Huisa BN, Edland SD, Litvan I, Peavy GM, Salmon DP, Hansen LA, Galasko DR, Brewer JB, González HM, Rissman RA. PMID: 30412501.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol. 2018 01; 135(1):85-93. Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS, Alzheimer’s Disease Neuroimaging Initiative. PMID: 29177679; PMCID: PMC5758038.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    33. Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer's disease. Alzheimers Res Ther. 2017 Aug 02; 9(1):55. Reas ET, Hagler DJ, White NS, Kuperman JM, Bartsch H, Cross K, Loi RQ, Balachandra AR, Meloy MJ, Wierenga CE, Galasko D, Brewer JB, Dale AM, McEvoy LK. PMID: 28764771; PMCID: PMC5539622.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    34. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS, Alzheimer's Disease Cooperative Study. PMID: 28381506; PMCID: PMC5409846.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCTClinical Trials
    35. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 2017 03 23; 6. Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. PMID: 28440221; PMCID: PMC5404919.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimals
    36. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 03; 14(3):e1002258. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. PMID: 28323831; PMCID: PMC5360219.
      View in: PubMed   Mentions: 177     Fields:    Translation:Humans
    37. Abnormalities in hippocampal volume of glioma patients prior to radiotherapy. Acta Oncol. 2017 Mar; 56(3):427-430. Karunamuni RA, Seibert TM, White NS, McEvoy L, Farid N, Brewer J, Dale AM, McDonald CR, Hattangadi-Gluth JA. PMID: 28156177; PMCID: PMC5426357.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity. Brain Res. 2017 03 01; 1658:11-24. Gimbel SI, Brewer JB, Maril A. PMID: 28073651; PMCID: PMC5867277.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    39. Cerebral Cortex Regions Selectively Vulnerable to Radiation Dose-Dependent Atrophy. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):910-918. Seibert TM, Karunamuni R, Kaifi S, Burkeen J, Connor M, Krishnan AP, White NS, Farid N, Bartsch H, Murzin V, Nguyen TT, Moiseenko V, Brewer JB, McDonald CR, Dale AM, Hattangadi-Gluth JA. PMID: 28333012; PMCID: PMC5403140.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansPHPublic Health
    40. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 28946567.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    41. Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry. 2017 02; 88(2):152-164. Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB, International FTD-Genomics Consortium (IFGC), , International Parkinson's Disease Genomics Consortium (IPDGC), , International Genomics of Alzheimer's Project (IGAP), , Momeni P, Schellenberg GD, Dillon WP, Sugrue LP, Hess CP, Yokoyama JS, Bonham LW, Rabinovici GD, Miller BL, Andreassen OA, Dale AM, Hardy J, Desikan RS. PMID: 27899424; PMCID: PMC5237405.
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    51. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 2015 Jun 09; 131(23):2061-2069. Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM, Inflammation working group, IGAP and DemGene Investigators. PMID: 25862742; PMCID: PMC4677995.
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    54. Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease. Alzheimers Dement. 2014 Jul; 10(4):421-429.e3. Hill DLG, Schwarz AJ, Isaac M, Pani L, Vamvakas S, Hemmings R, Carrillo MC, Yu P, Sun J, Beckett L, Boccardi M, Brewer J, Brumfield M, Cantillon M, Cole PE, Fox N, Frisoni GB, Jack C, Kelleher T, Luo F, Novak G, Maguire P, Meibach R, Patterson P, Bain L, Sampaio C, Raunig D, Soares H, Suhy J, Wang H, Wolz R, Stephenson D. PMID: 24985687.
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    55. Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury. Neuroimage Clin. 2014; 5:128-40. Brezova V, Moen KG, Skandsen T, Vik A, Brewer JB, Salvesen O, Håberg AK. PMID: 25068105; PMCID: PMC4110353.
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    59. Operationalizing hippocampal volume as an enrichment biomarker for amnestic mild cognitive impairment trials: effect of algorithm, test-retest variability, and cut point on trial cost, duration, and sample size. Neurobiol Aging. 2014 Apr; 35(4):808-18. Yu P, Sun J, Wolz R, Stephenson D, Brewer J, Fox NC, Cole PE, Jack CR, Hill DL, Schwarz AJ, Coalition Against Major Diseases and the Alzheimer's Disease Neuroimaging Initiative. PMID: 24211008; PMCID: PMC4201941.
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    97. Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates. J Cogn Neurosci. 2009 Jul; 21(7):1244-54. Hales JB, Israel SL, Swann NC, Brewer JB. PMID: 18752401; PMCID: PMC2674124.
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    98. High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):139-45. Kovacevic S, Rafii MS, Brewer JB, Alzheimer's Disease Neuroimaging Initiative. PMID: 19474571; PMCID: PMC2688740.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    99. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM, Alzheimer's Disease Neuroimaging Initiative. PMID: 19201945; PMCID: PMC2663582.
      View in: PubMed   Mentions: 154     Fields:    Translation:Humans
    100. Applications of neuroimaging to disease-modification trials in Alzheimer's disease. Behav Neurol. 2009; 21(1):129-36. Fleisher AS, Donohue M, Chen K, Brewer JB, Aisen PS, Alzheimer's Disease Neuroimaging Initiative. PMID: 19847051; PMCID: PMC5444278.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    101. Fully-automated volumetric MRI with normative ranges: translation to clinical practice. Behav Neurol. 2009; 21(1):21-8. Brewer JB. PMID: 19847042; PMCID: PMC5444284.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    102. Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease. AJNR Am J Neuroradiol. 2009 Mar; 30(3):578-80. Brewer JB, Magda S, Airriess C, Smith ME. PMID: 19112065; PMCID: PMC5947999.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    103. Item memory, source memory, and the medial temporal lobe: concordant findings from fMRI and memory-impaired patients. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9351-6. Gold JJ, Smith CN, Bayley PJ, Shrager Y, Brewer JB, Stark CE, Hopkins RO, Squire LR. PMID: 16751272; PMCID: PMC1482613.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    104. Imaging the medial temporal lobe: exploring new dimensions. Trends Cogn Sci. 2002 May 01; 6(5):217-223. Brewer JB, Moghekar A. PMID: 11983585.
      View in: PubMed   Mentions: 12     Fields:    
    105. Level of sustained entorhinal activity at study correlates with subsequent cued-recall performance: a functional magnetic resonance imaging study with high acquisition rate. Hippocampus. 1999; 9(1):35-44. Fernández G, Brewer JB, Zhao Z, Glover GH, Gabrieli JD. PMID: 10088898.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    106. Making memories: brain activity that predicts how well visual experience will be remembered. Science. 1998 Aug 21; 281(5380):1185-7. Brewer JB, Zhao Z, Desmond JE, Glover GH, Gabrieli JD. PMID: 9712581.
      View in: PubMed   Mentions: 288     Fields:    Translation:Humans
    107. Images of medial temporal lobe functions in human learning and memory. Neurobiol Learn Mem. 1998 Jul-Sep; 70(1-2):275-83. Gabrieli JD, Brewer JB, Poldrack RA. PMID: 9753602.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    108. Focusing in on the medial temporal lobe. Mol Psychiatry. 1997 Oct-Nov; 2(6):430-1, 427-8. Brewer JB, Gabrieli JD. PMID: 9399679.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    109. Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science. 1997 Apr 11; 276(5310):264-6. Gabrieli JD, Brewer JB, Desmond JE, Glover GH. PMID: 9092477.
      View in: PubMed   Mentions: 147     Fields:    Translation:Humans
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