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Xiang-dong Fu

Photo of Xiang-dong Fu
Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse overview
    Our laboratory is interested in molecular and cell biology of RNA processing; focus on SR proteins, SR protein kinases, and microarray analysis of alternative splicing in development and disease.

    Research Focus Areas:


    Collapse Research 
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    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH R01DK098808Sep 16, 2013 - Apr 30, 2023
    Role: Principal Investigator
    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH R56DK098808Sep 16, 2013 - Apr 30, 2019
    Role: Co-Principal Investigator
    Illumina Genome Analyzer II
    NIH S10RR025547Feb 15, 2009 - Feb 14, 2010
    Role: Principal Investigator
    Functional RNA elements in the human genome
    NIH R01HG004659Jun 1, 2008 - Apr 30, 2024
    Role: Principal Investigator
    Typing the Transcriptome in Cancer Using Splicing Array
    NIH R33CA114184Jun 1, 2005 - May 31, 2009
    Role: Principal Investigator
    A novel ChIP-on-Chip technology for ENCODE
    NIH R01HG003119Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH R33CA088351Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH R21CA088351Sep 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    Regulation of RNA metabolism and cell growth control by SR protein kinases
    NIH R01GM052872May 1, 1996 - Oct 31, 2020
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    Function and regulation of the human splicing factor SC35
    NIH R01GM049369May 1, 1993 - Jun 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Rep. 2022 04 05; 39(1):110626. Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Hutchins AP, Fu XD, Yao H. PMID: 35385732.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    2. Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis. Nat Plants. 2021 10; 7(10):1364-1378. Li L, Luo H, Lim DH, Han L, Li Y, Fu XD, Qi Y. PMID: 34650265.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    3. 3D genome encoded by LINE and SINE repeats. Cell Res. 2021 06; 31(6):603-604. Liang Z, Fu XD. PMID: 33623110; PMCID: PMC8169873.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nat Struct Mol Biol. 2021 02; 28(2):132-142. Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD. PMID: 33398173.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    5. Author Correction: A large-scale binding and functional map of human RNA-binding proteins. Nature. 2021 Jan; 589(7842):E5. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 33402748; PMCID: PMC7962576.
      View in: PubMed   Mentions: 8     Fields:    
    6. Active RNA interference in mitochondria. Cell Res. 2021 02; 31(2):219-228. Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X. PMID: 32807841; PMCID: PMC8027830.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    7. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 4     Fields:    
    8. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020 07; 583(7818):711-719. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 32728246; PMCID: PMC7410833.
      View in: PubMed   Mentions: 626     Fields:    Translation:HumansCells
    9. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    10. Author Correction: GRID-seq for comprehensive analysis of global RNA-chromatin interactions. Nat Protoc. 2020 06; 15(6):2140. Zhou B, Li X, Luo D, Lim DH, Zhou Y, Fu XD. PMID: 32060493.
      View in: PubMed   Mentions:    Fields:    
    11. RNA helicases regulate RNA condensates. Cell Res. 2020 04; 30(4):281-282. Fu XD. PMID: 32152418; PMCID: PMC7118144.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell. 2020 03 19; 180(6):1212-1227.e14. Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. PMID: 32169215; PMCID: PMC7190278.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    13. Author Correction: Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 Sep; 20(9):562. Li X, Fu XD. PMID: 31273305.
      View in: PubMed   Mentions: 1     Fields:    
    14. Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 09; 20(9):503-519. Li X, Fu XD. PMID: 31160792; PMCID: PMC7684979.
      View in: PubMed   Mentions: 117     Fields:    
    15. Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 2019 06 27; 178(1):107-121.e18. Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD. PMID: 31251911; PMCID: PMC6760001.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    16. GRID-seq for comprehensive analysis of global RNA-chromatin interactions. Nat Protoc. 2019 07; 14(7):2036-2068. Zhou B, Li X, Luo D, Lim DH, Zhou Y, Fu XD. PMID: 31175345; PMCID: PMC7721247.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1. Nat Protoc. 2019 05; 14(5):1661-1685. Chen JY, Zhang X, Fu XD, Chen L. PMID: 30996261; PMCID: PMC6604627.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    18. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6172-6180. Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD. PMID: 30867288; PMCID: PMC6442575.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. A novel class of microRNA-recognition elements that function only within open reading frames. Nat Struct Mol Biol. 2018 11; 25(11):1019-1027. Zhang K, Zhang X, Cai Z, Zhou J, Cao R, Zhao Y, Chen Z, Wang D, Ruan W, Zhao Q, Liu G, Xue Y, Qin Y, Zhou B, Wu L, Nilsen T, Zhou Y, Fu XD. PMID: 30297778; PMCID: PMC6219929.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    20. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 04 19; 25(4):460-470.e6. Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. PMID: 29478907; PMCID: PMC5973797.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    21. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018 02 01; 69(3):412-425.e6. Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD. PMID: 29395063; PMCID: PMC5957072.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    22. R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Mol Cell. 2017 Nov 16; 68(4):745-757.e5. Chen L, Chen JY, Zhang X, Gu Y, Xiao R, Shao C, Tang P, Qian H, Luo D, Li H, Zhou Y, Zhang DE, Fu XD. PMID: 29104020; PMCID: PMC5957070.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansCells
    23. Exploiting the Hidden Treasure of Detained Introns. Cancer Cell. 2017 10 09; 32(4):393-395. Fu XD. PMID: 29017049; PMCID: PMC5967397.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Mol Cell. 2016 06 16; 62(6):875-889. Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD. PMID: 27211866; PMCID: PMC5515591.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    25. Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis. Mol Neurodegener. 2016 Jan 22; 11:8. Lim SM, Choi WJ, Oh KW, Xue Y, Choi JY, Kim SH, Nahm M, Kim YE, Lee J, Noh MY, Lee S, Hwang S, Ki CS, Fu XD, Kim SH. PMID: 26795035; PMCID: PMC4722778.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    26. Diabetic Insult-Induced Redistribution of MicroRNA in Spatially Organized Mitochondria in Cardiac Muscle. Circ Cardiovasc Genet. 2015 Dec; 8(6):747-8. Marina RJ, Fu XD. PMID: 26671968; PMCID: PMC4683416.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing. Mol Cell Biol. 2015 Sep 01; 35(17):3071-82. Komeno Y, Huang YJ, Qiu J, Lin L, Xu Y, Zhou Y, Chen L, Monterroza DD, Li H, DeKelver RC, Yan M, Fu XD, Zhang DE. PMID: 26124281; PMCID: PMC4525309.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    28. Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. J Biol Chem. 2015 Aug 07; 290(32):19967-75. Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, Zhou J, Sun H, Fu XD. PMID: 26117336; PMCID: PMC4528155.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Yes, SiR. RNA. 2015 Apr; 21(4):619-21. Fu XD. PMID: 25780164; PMCID: PMC4371306.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    30. Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. Cell Rep. 2015 Mar 10; 10(9):1521-1533. Wei C, Qiu J, Zhou Y, Xue Y, Hu J, Ouyang K, Banerjee I, Zhang C, Chen B, Li H, Chen J, Song LS, Fu XD. PMID: 25753418; PMCID: PMC4559494.
      View in: PubMed   Mentions: 64     Fields:    
    31. MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell. 2014 Jul 31; 158(3):607-19. Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD. PMID: 25083871; PMCID: PMC4119298.
      View in: PubMed   Mentions: 264     Fields:    Translation:AnimalsCells
    32. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. PMID: 24703948; PMCID: PMC4019712.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
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