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Xiang-dong Fu

Photo of Xiang-dong Fu
Title(s)Professor, Cellular and Molecular Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Overview 
    Collapse overview
    Our laboratory is interested in molecular and cell biology of RNA processing; focus on SR proteins, SR protein kinases, and microarray analysis of alternative splicing in development and disease.

    Research Focus Areas:


    Collapse Research 
    Collapse research activities and funding
    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH R01DK098808Sep 16, 2013 - Apr 30, 2023
    Role: Principal Investigator
    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH R56DK098808Sep 16, 2013 - Apr 30, 2019
    Role: Co-Principal Investigator
    Illumina Genome Analyzer II
    NIH S10RR025547Feb 15, 2009 - Feb 14, 2010
    Role: Principal Investigator
    Functional RNA elements in the human genome
    NIH R01HG004659Jun 1, 2008 - Apr 30, 2024
    Role: Principal Investigator
    Typing the Transcriptome in Cancer Using Splicing Array
    NIH R33CA114184Jun 1, 2005 - May 31, 2009
    Role: Principal Investigator
    A novel ChIP-on-Chip technology for ENCODE
    NIH R01HG003119Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH R33CA088351Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH R21CA088351Sep 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    Regulation of RNA metabolism and cell growth control by SR protein kinases
    NIH R01GM052872May 1, 1996 - Oct 31, 2020
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    Function and regulation of the human splicing factor SC35
    NIH R01GM049369May 1, 1993 - Jun 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Diabetes knowledge, risk and severity perceptions, lifestyle behaviours and management barriers among Sub-Saharan African immigrants living in the UK: an ethnographic study. BMC Public Health. 2025 Aug 22; 25(1):2883. Onuorah L, Santy-Tomlinson J, Draper P. PMID: 40846934; PMCID: PMC12372270.
      View in: PubMed   Mentions:    Fields:    
    2. Graduate Students' Perspectives on Obtaining a Master's of Science in Respiratory Care. Respir Care. 2025 04; 70(4):384-392. Koster MS, McHenry KL, Caldwell-Chadwick BG, Null MM. PMID: 40193534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. BJPsych Open. 2025 Mar 10; 11(2):e42. He L, Yu W, Song H, Li L, Shen Y, Zhang L, Li H. PMID: 40059385; PMCID: PMC12001931.
      View in: PubMed   Mentions:
    4. Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation. Nat Commun. 2024 Jul 17; 15(1):6031. Zhang X, Xu J, Hu J, Zhang S, Hao Y, Zhang D, Qian H, Wang D, Fu XD. PMID: 39019869; PMCID: PMC11255242.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. RUNX1 C-terminal mutations impair blood cell differentiation by perturbing specific enhancer-promoter networks. Blood Adv. 2024 05 28; 8(10):2410-2423. Jayne ND, Liang Z, Lim DH, Chen PB, Diaz C, Arimoto KI, Xia L, Liu M, Ren B, Fu XD, Zhang DE. PMID: 38513139; PMCID: PMC11112616.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects. Am J Psychiatry. 2024 Jul 01; 181(7):639-650. Ironside M, Duda JM, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Chen X, Chen X, Nickerson LD, Null KE, Esfand SM, Alexander MM, Crowley DJ, Lauze M, Misra M, Goldstein JM, Pizzagalli DA. PMID: 38685857; PMCID: PMC11216878.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. [Determination of trace anions in battery-grade lithium carbonate by double-inhibition on-line matrix-removal ion chromatography]. Se Pu. 2024 Mar 08; 42(3):291-295. Wu G, Wu G, Wu GQ. PMID: 38503706; PMCID: PMC10951807.
      View in: PubMed   Mentions:    Fields:    
    8. Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 2023 06; 618(7964):E8-E13. Hao Y, Hu J, Xue Y, Dowdy SF, Mobley WC, Qian H, Fu XD. PMID: 37286647.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    9. Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy. 2023 08; 19(8):2257-2274. Li J, Li J, Zhou Y, Zhao W, Zhao W, Liu J, Liu J, Ullah R, Fang P, Fang L, Xiao S. PMID: 36779599; PMCID: PMC10351467.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    10. Sequential Polyadenylation to Enable Alternative mRNA 3' End Formation. Mol Cells. 2023 Jan 31; 46(1):57-64. Hao Y, Cai T, Liu C, Zhang X, Fu XD. PMID: 36697238; PMCID: PMC9880608.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    11. [Simultaneous determination of 28 fragrance components in cosmetics by gas chromatography-tandem mass spectrometry]. Se Pu. 2023 Jan; 41(1):76-86. Xu D, Wu Y, Wu Y, Wang Y, Chen F, Chen F, Zhang S, Lai G. PMID: 36633079; PMCID: PMC9841437.
      View in: PubMed   Mentions: 1     Fields:    
    12. [Determination of organophosphate diesters in facility vegetable soils using ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2023 Jan; 41(1):58-65. Liu M, Liu M, Wang M, Zhao A, Zhao A, Zhu L, Wang C, Wei C, Liu W, Xu J. PMID: 36633077; PMCID: PMC9837671.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease. Autophagy. 2023 07; 19(7):2166-2169. Montégut L, Joseph A, Chen H, Chen H, Abdellatif M, Ruckenstuhl C, Martins I, Madeo F, Kroemer G. PMID: 36579946; PMCID: PMC10283417.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS. Blood Adv. 2022 12 13; 6(23):6078-6092. Huang YJ, Chen JY, Yan M, Davis AG, Miyauchi S, Chen L, Hao Y, Katz S, Bejar R, Abdel-Wahab O, Fu XD, Zhang DE. PMID: 36206200; PMCID: PMC9772487.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2022 Sep; 24(9):1445. Gil J, Bernard D, Martínez D, Beach D. PMID: 35941232.
      View in: PubMed   Mentions: 1     Fields:    
    16. [Plasma metabolomics in a deep vein thrombosis rat model based on ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2022 Aug; 40(8):736-745. Gu Y, Zang P, Li J, Li J, Yan Y, Wang J. PMID: 35903841; PMCID: PMC9404070.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics. Genome Biol. 2022 07 25; 23(1):162. Hao Y, Zhang S, Shao C, Li J, Zhao G, Zhang DE, Fu XD. PMID: 35879727; PMCID: PMC9310463.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis. Autophagy. 2023 03; 19(3):768-783. Yan H, Zhuang M, Xu X, Li S, Li S, Yang M, Li N, Du X, Hu K, Peng X, Huang W, Wu H, Wu H, Tse YC, Zhao L, Wang H. PMID: 35786359; PMCID: PMC9980518.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression. J Exp Med. 2022 06 06; 219(6). Kanbar JN, Ma S, Kim ES, Kurd NS, Tsai MS, Tysl T, Widjaja CE, Limary AE, Yee B, He Z, Hao Y, Fu XD, Yeo GW, Huang WJ, Chang JT. PMID: 35593887; PMCID: PMC9127983.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    20. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Rep. 2022 04 05; 39(1):110626. Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Hutchins AP, Fu XD, Yao H. PMID: 35385732.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    21. ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance. J Clin Invest. 2022 03 15; 132(6). Jiang L, Hao Y, Shao C, Wu Q, Prager BC, Gimple RC, Sulli G, Kim LJ, Zhang G, Qiu Z, Zhu Z, Fu XD, Rich JN. PMID: 35133980; PMCID: PMC8920333.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    22. Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing. J Am Chem Soc. 2022 Mar 16; 144(10):4487-4495. Zhang D, Liu L, Jin S, Tota E, Li Z, Piao X, Zhang X, Fu XD, Devaraj NK. PMID: 35257575; PMCID: PMC9469474.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    23. Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer. Nat Commun. 2022 02 25; 13(1):1061. Ma S, Tang T, Probst G, Konradi A, Jin C, Li F, Gutkind JS, Fu XD, Guan KL. PMID: 35217640; PMCID: PMC8881512.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    24. Mapping R-Loops Using Catalytically Inactive RNaseH1 (R-ChIP). Methods Mol Biol. 2022; 2528:359-372. Zhang X, Hao Y, Fu XD. PMID: 35704204; PMCID: PMC12393161.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    25. PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle. Circulation. 2022 02 22; 145(8):586-602. Wu T, Liang Z, Zhang Z, Liu C, Zhang L, Gu Y, Peterson KL, Evans SM, Fu XD, Chen J. PMID: 34915728; PMCID: PMC8860879.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    26. Global profiling of RNA-chromatin interactions reveals co-regulatory gene expression networks in Arabidopsis. Nat Plants. 2021 10; 7(10):1364-1378. Li L, Luo H, Lim DH, Han L, Li Y, Fu XD, Qi Y. PMID: 34650265.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming. Annu Rev Genet. 2021 11 23; 55:45-69. Qian H, Fu XD. PMID: 34310194.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. 3D genome encoded by LINE and SINE repeats. Cell Res. 2021 06; 31(6):603-604. Liang Z, Fu XD. PMID: 33623110; PMCID: PMC8169873.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    29. Uniform criteria for total hip replacement surgery in patients with hip osteoarthritis: a decision tool to guide treatment decisions. Int J Qual Health Care. 2021 Mar 04; 33(1). Atsma F, Molenkamp O, Bouma H, Bolder SB, Groenewoud AS, Westert GP. PMID: 33616656; PMCID: PMC7941208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    30. TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nat Struct Mol Biol. 2021 02; 28(2):132-142. Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, Zhang X, Liang Y, Esteban MA, Zhou Y, Fu XD. PMID: 33398173.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    31. Author Correction: A large-scale binding and functional map of human RNA-binding proteins. Nature. 2021 Jan; 589(7842):E5. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 33402748; PMCID: PMC7962576.
      View in: PubMed   Mentions: 8     Fields:    
    32. Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25486-25493. Xu J, Wang W, Xu L, Chen JY, Chong J, Oh J, Leschziner AE, Fu XD, Wang D. PMID: 32989164; PMCID: PMC7568279.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. Active RNA interference in mitochondria. Cell Res. 2021 02; 31(2):219-228. Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X. PMID: 32807841; PMCID: PMC8027830.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    35. Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Aug; 584(7820):E17. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32724206.
      View in: PubMed   Mentions: 4     Fields:    
    36. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020 07; 583(7818):711-719. Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, Blue SM, Chen JY, Cody NAL, Dominguez D, Olson S, Sundararaman B, Zhan L, Bazile C, Bouvrette LPB, Bergalet J, Duff MO, Garcia KE, Gelboin-Burkhart C, Hochman M, Lambert NJ, Li H, McGurk MP, Nguyen TB, Palden T, Rabano I, Sathe S, Stanton R, Su A, Wang R, Yee BA, Zhou B, Louie AL, Aigner S, Fu XD, Lécuyer E, Burge CB, Graveley BR, Yeo GW. PMID: 32728246; PMCID: PMC7410833.
      View in: PubMed   Mentions: 626     Fields:    Translation:HumansCells
    37. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 06; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380; PMCID: PMC7521455.
      View in: PubMed   Mentions: 256     Fields:    Translation:HumansAnimalsCells
    38. Author Correction: GRID-seq for comprehensive analysis of global RNA-chromatin interactions. Nat Protoc. 2020 06; 15(6):2140. Zhou B, Li X, Luo D, Lim DH, Zhou Y, Fu XD. PMID: 32060493.
      View in: PubMed   Mentions:    Fields:    
    39. Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins. Genome Biol. 2020 04 06; 21(1):90. Van Nostrand EL, Pratt GA, Yee BA, Wheeler EC, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu XD, Graveley BR, Yeo GW. PMID: 32252787; PMCID: PMC7137325.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    40. RNA helicases regulate RNA condensates. Cell Res. 2020 04; 30(4):281-282. Fu XD. PMID: 32152418; PMCID: PMC7118144.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    41. Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Mar 28; 45(3):221-228. Liu J, Liu J, Liu J, Wang W. PMID: 32386011.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    42. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell. 2020 03 19; 180(6):1212-1227.e14. Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. PMID: 32169215; PMCID: PMC7190278.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    43. Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. Cancer Discov. 2020 03; 10(3):382-393. Fan JB, Miyauchi S, Xu HZ, Liu D, Kim LJY, Burkart C, Cheng H, Arimoto KI, Yan M, Zhou Y, Gyorffy B, Knobeloch KP, Rich JN, Cang H, Fu XD, Zhang DE. PMID: 31974171; PMCID: PMC7058499.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    44. Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels. Cold Spring Harb Symp Quant Biol. 2019; 84:55-66. Chen JY, Lim DH, Fu XD. PMID: 31900328; PMCID: PMC7332398.
      View in: PubMed   Mentions: 3     Fields:    
    45. A tumorigenic index for quantitative analysis of liver cancer initiation and progression. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26873-26880. Wang G, Luo X, Liang Y, Kaneko K, Li H, Fu XD, Feng GS. PMID: 31843886; PMCID: PMC6936392.
      View in: PubMed   Mentions: 6     Fields:    
    46. Author Correction: Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 Sep; 20(9):562. Li X, Fu XD. PMID: 31273305.
      View in: PubMed   Mentions: 1     Fields:    
    47. Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 09; 20(9):503-519. Li X, Fu XD. PMID: 31160792; PMCID: PMC7684979.
      View in: PubMed   Mentions: 117     Fields:    
    48. Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 2019 06 27; 178(1):107-121.e18. Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD. PMID: 31251911; PMCID: PMC6760001.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    49. GRID-seq for comprehensive analysis of global RNA-chromatin interactions. Nat Protoc. 2019 07; 14(7):2036-2068. Zhou B, Li X, Luo D, Lim DH, Zhou Y, Fu XD. PMID: 31175345; PMCID: PMC7721247.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    50. R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1. Nat Protoc. 2019 05; 14(5):1661-1685. Chen JY, Zhang X, Fu XD, Chen L. PMID: 30996261; PMCID: PMC6604627.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    51. Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019 07 02; 140(1):55-66. Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J. PMID: 30982350; PMCID: PMC6889818.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    52. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6172-6180. Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD. PMID: 30867288; PMCID: PMC6442575.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    53. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 30344044; PMCID: PMC6277851.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    54. A novel class of microRNA-recognition elements that function only within open reading frames. Nat Struct Mol Biol. 2018 11; 25(11):1019-1027. Zhang K, Zhang X, Cai Z, Zhou J, Cao R, Zhao Y, Chen Z, Wang D, Ruan W, Zhao Q, Liu G, Xue Y, Qin Y, Zhou B, Wu L, Nilsen T, Zhou Y, Fu XD. PMID: 30297778; PMCID: PMC6219929.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    55. PTB/nPTB: master regulators of neuronal fate in mammals. Biophys Rep. 2018; 4(4):204-214. Hu J, Qian H, Xue Y, Fu XD. PMID: 30310857; PMCID: PMC6153489.
      View in: PubMed   Mentions: 41  
    56. β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET. Hepatology. 2018 05; 67(5):1807-1822. Liang Y, Feng Y, Zong M, Wei XF, Lee J, Feng Y, Li H, Yang GS, Wu ZJ, Fu XD, Feng GS. PMID: 29152756; PMCID: PMC5906147.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    57. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform. Cell Chem Biol. 2018 04 19; 25(4):460-470.e6. Hatcher JM, Wu G, Zeng C, Zhu J, Meng F, Patel S, Wang W, Ficarro SB, Leggett AL, Powell CE, Marto JA, Zhang K, Ki Ngo JC, Fu XD, Zhang T, Gray NS. PMID: 29478907; PMCID: PMC5973797.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    58. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018 02 01; 69(3):412-425.e6. Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD. PMID: 29395063; PMCID: PMC5957072.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    59. R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Mol Cell. 2017 Nov 16; 68(4):745-757.e5. Chen L, Chen JY, Zhang X, Gu Y, Xiao R, Shao C, Tang P, Qian H, Luo D, Li H, Zhou Y, Zhang DE, Fu XD. PMID: 29104020; PMCID: PMC5957070.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansCells
    60. Exploiting the Hidden Treasure of Detained Introns. Cancer Cell. 2017 10 09; 32(4):393-395. Fu XD. PMID: 29017049; PMCID: PMC5967397.
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    61. GRID-seq reveals the global RNA-chromatin interactome. Nat Biotechnol. 2017 Oct; 35(10):940-950. Li X, Zhou B, Chen L, Gou LT, Li H, Fu XD. PMID: 28922346; PMCID: PMC5953555.
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    62. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01; 169(6):1090-1104.e13. Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ, Liu MF. PMID: 28552346; PMCID: PMC5985145.
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    63. Both sides of the same coin: Rac1 splicing regulating by EGF signaling. Cell Res. 2017 04; 27(4):455-456. Fu XD. PMID: 28186082; PMCID: PMC5385611.
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    64. MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation. Circulation. 2016 Sep 06; 134(10):734-51. Li H, Zhang X, Wang F, Zhou L, Yin Z, Fan J, Nie X, Wang P, Fu XD, Chen C, Wang DW. PMID: 27542393; PMCID: PMC5515592.
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    65. Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators. RNA. 2016 10; 22(10):1535-49. Qiu J, Zhou B, Thol F, Zhou Y, Chen L, Shao C, DeBoever C, Hou J, Li H, Chaturvedi A, Ganser A, Bejar R, Zhang DE, Fu XD, Heuser M. PMID: 27492256; PMCID: PMC5029452.
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    66. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. PMID: 27397683; PMCID: PMC4941815.
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    67. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife. 2016 06 02; 5. Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm AD, Jin Y. PMID: 27253061; PMCID: PMC4946901.
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    68. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Mol Cell. 2016 06 16; 62(6):875-889. Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD. PMID: 27211866; PMCID: PMC5515591.
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    69. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. PMID: 26944080; PMCID: PMC4812712.
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    70. Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis. Mol Neurodegener. 2016 Jan 22; 11:8. Lim SM, Choi WJ, Oh KW, Xue Y, Choi JY, Kim SH, Nahm M, Kim YE, Lee J, Noh MY, Lee S, Hwang S, Ki CS, Fu XD, Kim SH. PMID: 26795035; PMCID: PMC4722778.
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    71. Diabetic Insult-Induced Redistribution of MicroRNA in Spatially Organized Mitochondria in Cardiac Muscle. Circ Cardiovasc Genet. 2015 Dec; 8(6):747-8. Marina RJ, Fu XD. PMID: 26671968; PMCID: PMC4683416.
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    72. Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes Dev. 2015 Nov 15; 29(22):2377-90. Chen F, Zhou Y, Qi YB, Khivansara V, Li H, Chun SY, Kim JK, Fu XD, Jin Y. PMID: 26588990; PMCID: PMC4691892.
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    73. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 2015 Jul 30; 523(7562):621-5. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D. PMID: 26123024; PMCID: PMC4521995.
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    74. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing. Mol Cell Biol. 2015 Sep 01; 35(17):3071-82. Komeno Y, Huang YJ, Qiu J, Lin L, Xu Y, Zhou Y, Chen L, Monterroza DD, Li H, DeKelver RC, Yan M, Fu XD, Zhang DE. PMID: 26124281; PMCID: PMC4525309.
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    75. Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. J Biol Chem. 2015 Aug 07; 290(32):19967-75. Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, Zhou J, Sun H, Fu XD. PMID: 26117336; PMCID: PMC4528155.
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    76. Yes, SiR. RNA. 2015 Apr; 21(4):619-21. Fu XD. PMID: 25780164; PMCID: PMC4371306.
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    77. An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. Genes Dev. 2015 Mar 15; 29(6):603-16. Chang AT, Liu Y, Ayyanathan K, Benner C, Jiang Y, Prokop JW, Paz H, Wang D, Li HR, Fu XD, Rauscher FJ, Yang J. PMID: 25762439; PMCID: PMC4378193.
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    78. Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. Cell Rep. 2015 Mar 10; 10(9):1521-1533. Wei C, Qiu J, Zhou Y, Xue Y, Hu J, Ouyang K, Banerjee I, Zhang C, Chen B, Li H, Chen J, Song LS, Fu XD. PMID: 25753418; PMCID: PMC4559494.
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    79. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. PMID: 25529026; PMCID: PMC5053020.
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    80. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015 Jan 27; 6:6171. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. PMID: 25625564; PMCID: PMC4338613.
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    81. Genomic functions of U2AF in constitutive and regulated splicing. RNA Biol. 2015; 12(5):479-85. Wu T, Fu XD. PMID: 25901584; PMCID: PMC4615725.
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    82. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 24869919; PMCID: PMC5056641.
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    83. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet. 2014 Oct; 15(10):689-701. Fu XD, Ares M. PMID: 25112293; PMCID: PMC4440546.
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    84. MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell. 2014 Jul 31; 158(3):607-19. Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD. PMID: 25083871; PMCID: PMC4119298.
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    85. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature. 2014 Jul 17; 511(7509):358-61. Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K. PMID: 25030175; PMCID: PMC4610745.
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    86. Non-coding RNA: a new frontier in regulatory biology. Natl Sci Rev. 2014 Jun 01; 1(2):190-204. Fu XD. PMID: 25821635; PMCID: PMC4374487.
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    87. CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration. Cell. 2014 Apr 24; 157(3):651-63. Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG. PMID: 24766810; PMCID: PMC4128918.
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    88. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. PMID: 24703948; PMCID: PMC4019712.
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    89. Multiplex analysis of polyA-linked sequences (MAPS): an RNA-seq strategy to profile poly(A+) RNA. Methods Mol Biol. 2014; 1125:169-78. Zhou Y, Li HR, Huang J, Jin G, Fu XD. PMID: 24590789; PMCID: PMC4445727.
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    90. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. PMID: 24170860; PMCID: PMC3839752.
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    91. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 01; 13(2):246-54. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy SF. PMID: 23910086; PMCID: PMC3845961.
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    92. Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol. 2013 Aug 23; 425(16):2894-909. Aubol BE, Plocinik RM, Hagopian JC, Ma CT, McGlone ML, Bandyopadhyay R, Fu XD, Adams JA. PMID: 23707382; PMCID: PMC3860265.
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    93. Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Mol Cell. 2013 Apr 25; 50(2):223-35. Pandit S, Zhou Y, Shiue L, Coutinho-Mansfield G, Li H, Qiu J, Huang J, Yeo GW, Ares M, Fu XD. PMID: 23562324; PMCID: PMC3640356.
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    94. Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma. 2013 Jun; 122(3):191-207. Zhou Z, Fu XD. PMID: 23525660; PMCID: PMC3660409.
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    95. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17; 150(4):780-91. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. PMID: 22863277; PMCID: PMC3433174.
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    96. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell. 2012 Aug 10; 47(3):422-33. Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. PMID: 22727668; PMCID: PMC3418396.
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    97. RASL-seq for massively parallel and quantitative analysis of gene expression. Curr Protoc Mol Biol. 2012 Apr; Chapter 4:Unit 4.13.1-9. Li H, Qiu J, Fu XD. PMID: 22470064; PMCID: PMC3325489.
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    98. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. PMID: 22457638; PMCID: PMC3310790.
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    99. Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4609-14. Li H, Zhou H, Wang D, Qiu J, Zhou Y, Li X, Rosenfeld MG, Ding S, Fu XD. PMID: 22396588; PMCID: PMC3311343.
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    100. Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples. Front Genet. 2012; 3:11. Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. PMID: 22375143; PMCID: PMC3286152.
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    101. Tracking intron removal in real time. Dev Cell. 2011 Dec 13; 21(6):979-80. Hamilton BA, Fu XD. PMID: 22172665; PMCID: PMC4442631.
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    102. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics. 2011 Sep 10; 12:449. Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. PMID: 21906392; PMCID: PMC3179967.
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    103. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature. 2011 May 15; 474(7351):390-4. Wang D, Garcia-Bassets I, Benner C, Li W, Su X, Zhou Y, Qiu J, Liu W, Kaikkonen MU, Ohgi KA, Glass CK, Rosenfeld MG, Fu XD. PMID: 21572438; PMCID: PMC3117022.
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    104. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 01; 410(1):131-45. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings PA, Adams JA. PMID: 21600902; PMCID: PMC3121894.
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    105. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8233-8. Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. PMID: 21536904; PMCID: PMC3100968.
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    106. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011 Apr 22; 42(2):185-98. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE. PMID: 21504830; PMCID: PMC3137374.
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    107. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 2011 Jun; 21(6):336-43. Han J, Xiong J, Wang D, Fu XD. PMID: 21514162; PMCID: PMC6553873.
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    108. A multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation. Genomics. 2011 Oct; 98(4):266-71. Fox-Walsh K, Davis-Turak J, Zhou Y, Li H, Fu XD. PMID: 21515359; PMCID: PMC3160523.
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    109. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011 Feb 10; 470(7333):264-8. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu XD, Topol EJ, Rosenfeld MG, Frazer KA. PMID: 21307941; PMCID: PMC3079517.
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    110. RNA-seq analysis of gene expression and alternative splicing by double-random priming strategy. Methods Mol Biol. 2011; 729:247-55. Lovci MT, Li HR, Fu XD, Yeo GW. PMID: 21365495; PMCID: PMC3918474.
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    111. SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons. Mol Cell Biol. 2011 Feb; 31(4):793-802. Han J, Ding JH, Byeon CW, Kim JH, Hertel KJ, Jeong S, Fu XD. PMID: 21135118; PMCID: PMC3028638.
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    112. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol. 2010 Oct 29; 403(3):386-404. Ma CT, Ghosh G, Fu XD, Adams JA. PMID: 20826166; PMCID: PMC2994579.
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    113. Chromatin: the final frontier in splicing regulation? Dev Cell. 2010 Mar 16; 18(3):336-8. Fox-Walsh K, Fu XD. PMID: 20230741; PMCID: PMC6586464.
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    114. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell. 2009 Dec 11; 139(6):1069-83. Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass CK, Rosenfeld MG. PMID: 19962179; PMCID: PMC2812435.
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    115. DNA interaction networks: an information highway for regulated gene expression in the 3-dimentional space of the nucleus. Cell Res. 2009 Dec; 19(12):1316-9. Wang D, Fu XD. PMID: 19956184; PMCID: PMC6555147.
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    116. Nuclear organization in the 3D space of the nucleus - cause or consequence? Curr Opin Genet Dev. 2009 Oct; 19(5):424-36. Nunez E, Fu XD, Rosenfeld MG. PMID: 19846290; PMCID: PMC2796509.
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    117. SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell. 2009 Jul 10; 35(1):1-10. Zhong XY, Wang P, Han J, Rosenfeld MG, Fu XD. PMID: 19595711; PMCID: PMC2744344.
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    118. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009 Feb 15; 23(4):482-95. Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. PMID: 19240134; PMCID: PMC2648651.
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    119. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol. 2009 Feb; 16(2):130-7. Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH. PMID: 19136955; PMCID: PMC2735254.
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    120. Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20179-84. Li H, Lovci MT, Kwon YS, Rosenfeld MG, Fu XD, Yeo GW. PMID: 19088194; PMCID: PMC2603435.
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    121. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. PMID: 18687337; PMCID: PMC2741138.
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    122. The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol. 2008 Aug; 15(8):819-26. Lin S, Coutinho-Mansfield G, Wang D, Pandit S, Fu XD. PMID: 18641664; PMCID: PMC2574591.
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    123. Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol. 2008 Jun; 20(3):260-5. Pandit S, Wang D, Fu XD. PMID: 18436438; PMCID: PMC2701685.
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    124. Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell. 2008 Mar 21; 132(6):996-1010. Nunez E, Kwon YS, Hutt KR, Hu Q, Cardamone MD, Ohgi KA, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG, Fu XD. PMID: 18358812.
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    125. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14; 29(5):563-76. Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. PMID: 18342604; PMCID: PMC2852395.
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    126. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol. 2008 Feb 08; 376(1):55-68. Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 18155240.
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    127. PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation. Genes Dev. 2007 Jul 01; 21(13):1573-7. Coutinho-Mansfield GC, Xue Y, Zhang Y, Fu XD. PMID: 17606635.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    128. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10; 282(32):23036-43. Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. PMID: 17517895.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    129. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19; 446(7138):882-7. Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG. PMID: 17392792.
      View in: PubMed   Mentions: 333     Fields:    Translation:AnimalsCells
    130. Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4852-7. Kwon YS, Garcia-Bassets I, Hutt KR, Cheng CS, Jin M, Liu D, Benner C, Wang D, Ye Z, Bibikova M, Fan JB, Duan L, Glass CK, Rosenfeld MG, Fu XD. PMID: 17360330; PMCID: PMC1821125.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    131. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 2007 Feb 09; 128(3):505-518. Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass CK, Fu XD, Rosenfeld MG. PMID: 17289570; PMCID: PMC1994663.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansCells
    132. SR protein kinase 1 is resilient to inactivation. Structure. 2007 Jan; 15(1):123-33. Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. PMID: 17223538.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    133. SR proteins and related factors in alternative splicing. Adv Exp Med Biol. 2007; 623:107-22. Lin S, Fu XD. PMID: 18380343.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    134. Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Res. 2006 Apr 15; 66(8):4079-88. Li HR, Wang-Rodriguez J, Nair TM, Yeakley JM, Kwon YS, Bibikova M, Zheng C, Zhou L, Zhang K, Downs T, Fu XD, Fan JB. PMID: 16618727.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    135. Conditional knockout mice to study alternative splicing in vivo. Methods. 2005 Dec; 37(4):387-92. Xu X, Fu XD. PMID: 16314268.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    136. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell. 2006 Feb; 17(2):876-85. Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. PMID: 16319169; PMCID: PMC1356596.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    137. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell. 2005 Nov 11; 20(3):413-25. Lin S, Xiao R, Sun P, Xu X, Fu XD. PMID: 16285923.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    138. Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse. RNA. 2005 Dec; 11(12):1777-87. Zheng CL, Fu XD, Gribskov M. PMID: 16251388; PMCID: PMC1370866.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    139. MAASE: an alternative splicing database designed for supporting splicing microarray applications. RNA. 2005 Dec; 11(12):1767-76. Zheng CL, Kwon YS, Li HR, Zhang K, Coutinho-Mansfield G, Yang C, Nair TM, Gribskov M, Fu XD. PMID: 16251387; PMCID: PMC1370865.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    140. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem. 2005 Dec 16; 280(50):41761-8. Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. PMID: 16223727.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    141. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. PMID: 16209947.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    142. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 2005 Jan 14; 120(1):59-72. Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J, Chen J, Xiao RP, Cheng H, Fu XD. PMID: 15652482.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimalsCells
    143. Towards a splicing code. Cell. 2004 Dec 17; 119(6):736-8. Fu XD. PMID: 15607969.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    144. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004 Feb 25; 23(4):885-96. Ding JH, Xu X, Yang D, Chu PH, Dalton ND, Ye Z, Yeakley JM, Cheng H, Xiao RP, Ross J, Chen J, Fu XD. PMID: 14963485; PMCID: PMC380988.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    145. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12601-6. Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. PMID: 14555757; PMCID: PMC240664.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    146. Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators. J Biol Chem. 2003 May 16; 278(20):18050-5. Yun CY, Velazquez-Dones AL, Lyman SK, Fu XD. PMID: 12637531.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    147. Profiling alternative splicing on fiber-optic arrays. Nat Biotechnol. 2002 Apr; 20(4):353-8. Yeakley JM, Fan JB, Doucet D, Luo L, Wickham E, Ye Z, Chee MS, Fu XD. PMID: 11923840.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
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