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Xiang-Dong Fu

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0651
La Jolla CA 92093
Phone858-534-4937
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    Collapse Overview 
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    Our laboratory is interested in molecular and cell biology of RNA processing; focus on SR proteins, SR protein kinases, and microarray analysis of alternative splicing in development and disease.

    Research Focus Areas:


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    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH/NIDDK R56DK098808Sep 16, 2013 - Aug 31, 2019
    Role: Co-Principal Investigator
    Synergestic roles of SRF2 and RUNX1 in blood cell development and pathology
    NIH/NIDDK R01DK098808Sep 16, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Illumina Genome Analyzer II
    NIH/NCRR S10RR025547Feb 15, 2009 - Feb 14, 2010
    Role: Principal Investigator
    Functional RNA elements in the human genome
    NIH/NHGRI R01HG004659Jun 1, 2008 - May 31, 2014
    Role: Principal Investigator
    Typing the Transcriptome in Cancer Using Splicing Array
    NIH/NCI R33CA114184Jun 1, 2005 - May 31, 2009
    Role: Principal Investigator
    A novel ChIP-on-Chip technology for ENCODE
    NIH/NHGRI R01HG003119Sep 30, 2003 - Jul 31, 2007
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH/NCI R33CA088351Sep 1, 2000 - Aug 31, 2005
    Role: Principal Investigator
    CANCER CLASSIFICATION BASED ON MRNA ISOFORMS
    NIH/NCI R21CA088351Sep 1, 2000 - Aug 31, 2001
    Role: Principal Investigator
    Regulation of RNA metabolism and cell growth control by SR protein kinases
    NIH/NIGMS R01GM052872May 1, 1996 - Nov 30, 2010
    Role: Principal Investigator
    NATIONAL BIOMEDICAL COMPUTATION RESOURCE
    NIH P41RR008605Apr 15, 1994 - Apr 30, 2014
    Role: Co-Investigator
    Function and regulation of the human splicing factor SC35
    NIH/NIGMS R01GM049369May 1, 1993 - Nov 30, 2006
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 2020 Jun; 582(7813):550-556. Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD. PMID: 32581380.
      View in: PubMed   Mentions:    Fields:    
    2. Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins. Genome Biol. 2020 Apr 06; 21(1):90. Van Nostrand EL, Pratt GA, Yee BA, Wheeler EC, Blue SM, Mueller J, Park SS, Garcia KE, Gelboin-Burkhart C, Nguyen TB, Rabano I, Stanton R, Sundararaman B, Wang R, Fu XD, Graveley BR, Yeo GW. PMID: 32252787.
      View in: PubMed   Mentions: 1     Fields:    
    3. RNA helicases regulate RNA condensates. Cell Res. 2020 Apr; 30(4):281-282. Fu XD. PMID: 32152418.
      View in: PubMed   Mentions:    Fields:    
    4. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. Cell. 2020 Mar 19; 180(6):1212-1227.e14. Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. PMID: 32169215.
      View in: PubMed   Mentions:    Fields:    
    5. Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing. Cancer Discov. 2020 Mar; 10(3):382-393. Fan JB, Miyauchi S, Xu HZ, Liu D, Kim LJY, Burkart C, Cheng H, Arimoto KI, Yan M, Zhou Y, Gyorffy B, Knobeloch KP, Rich JN, Cang H, Fu XD, Zhang DE. PMID: 31974171.
      View in: PubMed   Mentions:    Fields:    
    6. Mechanistic Dissection of RNA-Binding Proteins in Regulated Gene Expression at Chromatin Levels. Cold Spring Harb Symp Quant Biol. 2020 Jan 03. Chen JY, Lim DH, Fu XD. PMID: 31900328.
      View in: PubMed   Mentions:    Fields:    
    7. A tumorigenic index for quantitative analysis of liver cancer initiation and progression. Proc Natl Acad Sci U S A. 2019 Dec 16. Wang G, Luo X, Liang Y, Kaneko K, Li H, Fu XD, Feng GS. PMID: 31843886.
      View in: PubMed   Mentions:    Fields:    
    8. Author Correction: Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 Sep; 20(9):562. Li X, Fu XD. PMID: 31273305.
      View in: PubMed   Mentions:    Fields:    
    9. Chromatin-associated RNAs as facilitators of functional genomic interactions. Nat Rev Genet. 2019 09; 20(9):503-519. Li X, Fu XD. PMID: 31160792.
      View in: PubMed   Mentions: 6     Fields:    
    10. Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell. 2019 06 27; 178(1):107-121.e18. Xiao R, Chen JY, Liang Z, Luo D, Chen G, Lu ZJ, Chen Y, Zhou B, Li H, Du X, Yang Y, San M, Wei X, Liu W, Lécuyer E, Graveley BR, Yeo GW, Burge CB, Zhang MQ, Zhou Y, Fu XD. PMID: 31251911.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. R-ChIP for genome-wide mapping of R-loops by using catalytically inactive RNASEH1. Nat Protoc. 2019 05; 14(5):1661-1685. Chen JY, Zhang X, Fu XD, Chen L. PMID: 30996261.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation. Circulation. 2019 07 02; 140(1):55-66. Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J. PMID: 30982350.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6172-6180. Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD. PMID: 30867288.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018 11 21; 100(4):816-830.e7. López-Erauskin J, Tadokoro T, Baughn MW, Myers B, McAlonis-Downes M, Chillon-Marinas C, Asiaban JN, Artates J, Bui AT, Vetto AP, Lee SK, Le AV, Sun Y, Jambeau M, Boubaker J, Swing D, Qiu J, Hicks GG, Ouyang Z, Fu XD, Tessarollo L, Ling SC, Parone PA, Shaw CE, Marsala M, Lagier-Tourenne C, Cleveland DW, Da Cruz S. PMID: 30344044.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. PTB/nPTB: master regulators of neuronal fate in mammals. Biophys Rep. 2018; 4(4):204-214. Hu J, Qian H, Xue Y, Fu XD. PMID: 30310857.
      View in: PubMed   Mentions:
    16. ß-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic ß-catenin and MET. Hepatology. 2018 05; 67(5):1807-1822. Liang Y, Feng Y, Zong M, Wei XF, Lee J, Feng Y, Li H, Yang GS, Wu ZJ, Fu XD, Feng GS. PMID: 29152756.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Mol Cell. 2018 02 01; 69(3):412-425.e6. Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD. PMID: 29395063.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    18. R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Mol Cell. 2017 Nov 16; 68(4):745-757.e5. Chen L, Chen JY, Zhang X, Gu Y, Xiao R, Shao C, Tang P, Qian H, Luo D, Li H, Zhou Y, Zhang DE, Fu XD. PMID: 29104020.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    19. Exploiting the Hidden Treasure of Detained Introns. Cancer Cell. 2017 10 09; 32(4):393-395. Fu XD. PMID: 29017049.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    20. GRID-seq reveals the global RNA-chromatin interactome. Nat Biotechnol. 2017 Oct; 35(10):940-950. Li X, Zhou B, Chen L, Gou LT, Li H, Fu XD. PMID: 28922346.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    21. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01; 169(6):1090-1104.e13. Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua MM, Lu Y, Zhu Y, Li Z, Chen H, Wu LG, Li D, Fu XD, Li J, Shi HJ, Liu MF. PMID: 28552346.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Both sides of the same coin: Rac1 splicing regulating by EGF signaling. Cell Res. 2017 04; 27(4):455-456. Fu XD. PMID: 28186082.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial Translation. Circulation. 2016 Sep 06; 134(10):734-51. Li H, Zhang X, Wang F, Zhou L, Yin Z, Fan J, Nie X, Wang P, Fu XD, Chen C, Wang DW. PMID: 27542393.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    24. Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators. RNA. 2016 10; 22(10):1535-49. Qiu J, Zhou B, Thol F, Zhou Y, Chen L, Shao C, DeBoever C, Hou J, Li H, Chaturvedi A, Ganser A, Bejar R, Zhang DE, Fu XD, Heuser M. PMID: 27492256.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing. Mol Cell. 2016 07 21; 63(2):218-228. Aubol BE, Wu G, Keshwani MM, Movassat M, Fattet L, Hertel KJ, Fu XD, Adams JA. PMID: 27397683.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    26. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins. Elife. 2016 06 02; 5. Chen L, Liu Z, Zhou B, Wei C, Zhou Y, Rosenfeld MG, Fu XD, Chisholm AD, Jin Y. PMID: 27253061.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Mol Cell. 2016 06 16; 62(6):875-889. Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD. PMID: 27211866.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction. Proc Natl Acad Sci U S A. 2016 Mar 22; 113(12):3185-90. Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A. PMID: 26944080.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    29. Diabetic Insult-Induced Redistribution of MicroRNA in Spatially Organized Mitochondria in Cardiac Muscle. Circ Cardiovasc Genet. 2015 Dec; 8(6):747-8. Marina RJ, Fu XD. PMID: 26671968.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes Dev. 2015 Nov 15; 29(22):2377-90. Chen F, Zhou Y, Qi YB, Khivansara V, Li H, Chun SY, Kim JK, Fu XD, Jin Y. PMID: 26588990.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 2015 Jul 30; 523(7562):621-5. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D. PMID: 26123024.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    32. SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing. Mol Cell Biol. 2015 Sep 01; 35(17):3071-82. Komeno Y, Huang YJ, Qiu J, Lin L, Xu Y, Zhou Y, Chen L, Monterroza DD, Li H, DeKelver RC, Yan M, Fu XD, Zhang DE. PMID: 26124281.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. Yes, SiR. RNA. 2015 Apr; 21(4):619-21. Fu XD. PMID: 25780164.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    34. An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors. Genes Dev. 2015 Mar 15; 29(6):603-16. Chang AT, Liu Y, Ayyanathan K, Benner C, Jiang Y, Prokop JW, Paz H, Wang D, Li HR, Fu XD, Rauscher FJ, Yang J. PMID: 25762439.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    35. Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. Cell Rep. 2015 Mar 10; 10(9):1521-1533. Wei C, Qiu J, Zhou Y, Xue Y, Hu J, Ouyang K, Banerjee I, Zhang C, Chen B, Li H, Chen J, Song LS, Fu XD. PMID: 25753418.
      View in: PubMed   Mentions: 25     Fields:    
    36. Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J. 2015 Mar 01; 466(2):311-22. Keshwani MM, Aubol BE, Fattet L, Ma CT, Qiu J, Jennings PA, Fu XD, Adams JA. PMID: 25529026.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015 Jan 27; 6:6171. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. PMID: 25625564.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    38. Genomic functions of U2AF in constitutive and regulated splicing. RNA Biol. 2015; 12(5):479-85. Wu T, Fu XD. PMID: 25901584.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    39. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J. 2014 Aug 15; 462(1):143-52. Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 24869919.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    40. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet. 2014 Oct; 15(10):689-701. Fu XD, Ares M. PMID: 25112293.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
    41. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature. 2014 Jul 17; 511(7509):358-61. Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K. PMID: 25030175.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    42. Non-coding RNA: a new frontier in regulatory biology. Natl Sci Rev. 2014 Jun 01; 1(2):190-204. Fu XD. PMID: 25821635.
      View in: PubMed   Mentions:
    43. CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration. Cell. 2014 Apr 24; 157(3):651-63. Schaffer AE, Eggens VR, Caglayan AO, Reuter MS, Scott E, Coufal NG, Silhavy JL, Xue Y, Kayserili H, Yasuno K, Rosti RO, Abdellateef M, Caglar C, Kasher PR, Cazemier JL, Weterman MA, Cantagrel V, Cai N, Zweier C, Altunoglu U, Satkin NB, Aktar F, Tuysuz B, Yalcinkaya C, Caksen H, Bilguvar K, Fu XD, Trotta CR, Gabriel S, Reis A, Gunel M, Baas F, Gleeson JG. PMID: 24766810.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    44. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014 May 08; 54(3):378-91. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD. PMID: 24703948.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    45. Multiplex analysis of polyA-linked sequences (MAPS): an RNA-seq strategy to profile poly(A+) RNA. Methods Mol Biol. 2014; 1125:169-78. Zhou Y, Li HR, Huang J, Jin G, Fu XD. PMID: 24590789.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    46. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4530-9. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. PMID: 24170860.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    47. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 01; 13(2):246-54. Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy SF. PMID: 23910086.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    48. Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol. 2013 Aug 23; 425(16):2894-909. Aubol BE, Plocinik RM, Hagopian JC, Ma CT, McGlone ML, Bandyopadhyay R, Fu XD, Adams JA. PMID: 23707382.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    49. Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Mol Cell. 2013 Apr 25; 50(2):223-35. Pandit S, Zhou Y, Shiue L, Coutinho-Mansfield G, Li H, Qiu J, Huang J, Yeo GW, Ares M, Fu XD. PMID: 23562324.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    50. Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma. 2013 Jun; 122(3):191-207. Zhou Z, Fu XD. PMID: 23525660.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    51. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17; 150(4):780-91. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. PMID: 22863277.
      View in: PubMed   Mentions: 433     Fields:    Translation:HumansAnimalsCells
    52. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell. 2012 Aug 10; 47(3):422-33. Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. PMID: 22727668.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    53. RASL-seq for massively parallel and quantitative analysis of gene expression. Curr Protoc Mol Biol. 2012 Apr; Chapter 4:Unit 4.13.1-9. Li H, Qiu J, Fu XD. PMID: 22470064.
      View in: PubMed   Mentions: 38     Fields:    
    54. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. PMID: 22457638.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    55. Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4609-14. Li H, Zhou H, Wang D, Qiu J, Zhou Y, Li X, Rosenfeld MG, Ding S, Fu XD. PMID: 22396588.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    56. Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples. Front Genet. 2012; 3:11. Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. PMID: 22375143.
      View in: PubMed   Mentions:
    57. Tracking intron removal in real time. Dev Cell. 2011 Dec 13; 21(6):979-80. Hamilton BA, Fu XD. PMID: 22172665.
      View in: PubMed   Mentions: 2     Fields:    
    58. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics. 2011 Sep 10; 12:449. Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. PMID: 21906392.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    59. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature. 2011 May 15; 474(7351):390-4. Wang D, Garcia-Bassets I, Benner C, Li W, Su X, Zhou Y, Qiu J, Liu W, Kaikkonen MU, Ohgi KA, Glass CK, Rosenfeld MG, Fu XD. PMID: 21572438.
      View in: PubMed   Mentions: 366     Fields:    Translation:HumansCells
    60. Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol. 2011 Jul 01; 410(1):131-45. Plocinik RM, Li S, Liu T, Hailey KL, Whitesides J, Whitehouse J, Ma CT, Fu XD, Gosh G, Woods VL, Jennings PA, Adams JA. PMID: 21600902.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    61. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8233-8. Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. PMID: 21536904.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    62. SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell. 2011 Apr 22; 42(2):185-98. Ahn EY, DeKelver RC, Lo MC, Nguyen TA, Matsuura S, Boyapati A, Pandit S, Fu XD, Zhang DE. PMID: 21504830.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    63. Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol. 2011 Jun; 21(6):336-43. Han J, Xiong J, Wang D, Fu XD. PMID: 21514162.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    64. A multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation. Genomics. 2011 Oct; 98(4):266-71. Fox-Walsh K, Davis-Turak J, Zhou Y, Li H, Fu XD. PMID: 21515359.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    65. 9p21 DNA variants associated with coronary artery disease impair interferon-? signalling response. Nature. 2011 Feb 10; 470(7333):264-8. Harismendy O, Notani D, Song X, Rahim NG, Tanasa B, Heintzman N, Ren B, Fu XD, Topol EJ, Rosenfeld MG, Frazer KA. PMID: 21307941.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansCells
    66. RNA-seq analysis of gene expression and alternative splicing by double-random priming strategy. Methods Mol Biol. 2011; 729:247-55. Lovci MT, Li HR, Fu XD, Yeo GW. PMID: 21365495.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    67. SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons. Mol Cell Biol. 2011 Feb; 31(4):793-802. Han J, Ding JH, Byeon CW, Kim JH, Hertel KJ, Jeong S, Fu XD. PMID: 21135118.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    68. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol. 2010 Oct 29; 403(3):386-404. Ma CT, Ghosh G, Fu XD, Adams JA. PMID: 20826166.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    69. Chromatin: the final frontier in splicing regulation? Dev Cell. 2010 Mar 16; 18(3):336-8. Fox-Walsh K, Fu XD. PMID: 20230741.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell. 2009 Dec 11; 139(6):1069-83. Lin C, Yang L, Tanasa B, Hutt K, Ju BG, Ohgi K, Zhang J, Rose DW, Fu XD, Glass CK, Rosenfeld MG. PMID: 19962179.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    71. DNA interaction networks: an information highway for regulated gene expression in the 3-dimentional space of the nucleus. Cell Res. 2009 Dec; 19(12):1316-9. Wang D, Fu XD. PMID: 19956184.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    72. Nuclear organization in the 3D space of the nucleus - cause or consequence? Curr Opin Genet Dev. 2009 Oct; 19(5):424-36. Nunez E, Fu XD, Rosenfeld MG. PMID: 19846290.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    73. SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell. 2009 Jul 10; 35(1):1-10. Zhong XY, Wang P, Han J, Rosenfeld MG, Fu XD. PMID: 19595711.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    74. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev. 2009 Feb 15; 23(4):482-95. Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. PMID: 19240134.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    75. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol. 2009 Feb; 16(2):130-7. Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH. PMID: 19136955.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansCells
    76. Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20179-84. Li H, Lovci MT, Kwon YS, Rosenfeld MG, Fu XD, Yeo GW. PMID: 19088194.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    77. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol. 2008 Oct 17; 382(4):894-909. Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. PMID: 18687337.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    78. The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol. 2008 Aug; 15(8):819-26. Lin S, Coutinho-Mansfield G, Wang D, Pandit S, Fu XD. PMID: 18641664.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    79. Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol. 2008 Jun; 20(3):260-5. Pandit S, Wang D, Fu XD. PMID: 18436438.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    80. Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell. 2008 Mar 21; 132(6):996-1010. Nunez E, Kwon YS, Hutt KR, Hu Q, Cardamone MD, Ohgi KA, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG, Fu XD. PMID: 18358812.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    81. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell. 2008 Mar 14; 29(5):563-76. Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. PMID: 18342604.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    82. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol. 2008 Feb 08; 376(1):55-68. Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. PMID: 18155240.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    83. PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation. Genes Dev. 2007 Jul 01; 21(13):1573-7. Coutinho-Mansfield GC, Xue Y, Zhang Y, Fu XD. PMID: 17606635.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    84. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem. 2007 Aug 10; 282(32):23036-43. Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. PMID: 17517895.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    85. Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19; 446(7138):882-7. Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG. PMID: 17392792.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    86. Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):4852-7. Kwon YS, Garcia-Bassets I, Hutt KR, Cheng CS, Jin M, Liu D, Benner C, Wang D, Ye Z, Bibikova M, Fan JB, Duan L, Glass CK, Rosenfeld MG, Fu XD. PMID: 17360330.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    87. Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell. 2007 Feb 09; 128(3):505-518. Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass CK, Fu XD, Rosenfeld MG. PMID: 17289570.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansCells
    88. SR protein kinase 1 is resilient to inactivation. Structure. 2007 Jan; 15(1):123-33. Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. PMID: 17223538.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    89. SR proteins and related factors in alternative splicing. Adv Exp Med Biol. 2007; 623:107-22. Lin S, Fu XD. PMID: 18380343.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    90. Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Res. 2006 Apr 15; 66(8):4079-88. Li HR, Wang-Rodriguez J, Nair TM, Yeakley JM, Kwon YS, Bibikova M, Zheng C, Zhou L, Zhang K, Downs T, Fu XD, Fan JB. PMID: 16618727.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    91. Conditional knockout mice to study alternative splicing in vivo. Methods. 2005 Dec; 37(4):387-92. Xu X, Fu XD. PMID: 16314268.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    92. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell. 2006 Feb; 17(2):876-85. Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. PMID: 16319169.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    93. Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell. 2005 Nov 11; 20(3):413-25. Lin S, Xiao R, Sun P, Xu X, Fu XD. PMID: 16285923.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    94. Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse. RNA. 2005 Dec; 11(12):1777-87. Zheng CL, Fu XD, Gribskov M. PMID: 16251388.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    95. MAASE: an alternative splicing database designed for supporting splicing microarray applications. RNA. 2005 Dec; 11(12):1767-76. Zheng CL, Kwon YS, Li HR, Zhang K, Coutinho-Mansfield G, Yang C, Nair TM, Gribskov M, Fu XD. PMID: 16251387.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    96. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem. 2005 Dec 16; 280(50):41761-8. Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. PMID: 16223727.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    97. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell. 2005 Oct 07; 20(1):77-89. Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. PMID: 16209947.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    98. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 2005 Jan 14; 120(1):59-72. Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J, Chen J, Xiao RP, Cheng H, Fu XD. PMID: 15652482.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    99. Towards a splicing code. Cell. 2004 Dec 17; 119(6):736-8. Fu XD. PMID: 15607969.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    100. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 2004 Feb 25; 23(4):885-96. Ding JH, Xu X, Yang D, Chu PH, Dalton ND, Ye Z, Yeakley JM, Cheng H, Xiao RP, Ross J, Chen J, Fu XD. PMID: 14963485.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    101. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12601-6. Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. PMID: 14555757.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    102. Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators. J Biol Chem. 2003 May 16; 278(20):18050-5. Yun CY, Velazquez-Dones AL, Lyman SK, Fu XD. PMID: 12637531.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    103. Profiling alternative splicing on fiber-optic arrays. Nat Biotechnol. 2002 Apr; 20(4):353-8. Yeakley JM, Fan JB, Doucet D, Luo L, Wickham E, Ye Z, Chee MS, Fu XD. PMID: 11923840.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
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