Amir Zarrinpar

Title(s)Assistant Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    AGA2014  - 2016AGA Microbiome Junior Investigator Research Award
    AASLD2014  - 2017Liver Scholar Award
    Larry L. Hillblom Foundation2014  - 2014Larry L. Hillblom Foundation Award Seed Grant (could not hold with Liver Scholar Award)
    UCSD - CTRI2014  - 2014UCSD KL2 Grant (could not hold with Liver Scholar Award)
    AGA2013  - 2014AGA Elsevier Pilot Research Grant
    Salix Inc.2013  - 2013Fellowship2Leadership Fellow

    Collapse Overview 
    Collapse Overview
    As the health burden of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) increases, I hope to perform high impact research investigating novel therapeutic pathways in these diseases that, as of yet, have few curative options.

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer
    NIH U01CA265719Sep 21, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Design and characterization of bacterial population dynamics in solid tumor models
    NIH R01EB030134Aug 1, 2021 - Apr 30, 2025
    Role: Co-Principal Investigator
    The Role of Altered Luminal Dynamics in OSA-Induced Atherosclerosis
    NIH R01HL148801Jul 10, 2019 - Jun 30, 2024
    Role: Principal Investigator
    The effect of luminal bile acid biotransformations on host cognition
    NIH R21MH117780Jul 1, 2018 - May 31, 2020
    Role: Principal Investigator
    The Effects of Bile Acid Conjugation Through Engineered Probiotics on Gut Luminal signaling and Metabolism
    NIH R03DK114536Aug 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    The Relationship of Gut Microbiome and Time Restricted Feeding in Metabolism
    NIH K08DK102902Sep 30, 2015 - Jul 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Obesity, Chronic Stress, and Stress Reduction. Gastroenterol Clin North Am. 2023 Jun; 52(2):347-362. Goens D, Virzi NE, Jung SE, Rutledge TR, Zarrinpar A. PMID: 37197878.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Complete Genome Sequence of an Escherichia coli Strain Isolated from Laboratory Mouse Stool for Use as a Chassis for Transgene Delivery to the Murine Microbiome. Microbiol Resour Announc. 2023 Apr 18; 12(4):e0101422. Siguenza N, Russell BJ, Richter RA, Zarrinpar A. PMID: 36856451; PMCID: PMC10112262.
      View in: PubMed   Mentions:
    3. The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases. Gastroenterology. 2023 Feb 24. Fogelson KA, Dorrestein PC, Zarrinpar A, Knight R. PMID: 36841488.
      View in: PubMed   Mentions:    Fields:    
    4. What is the key challenge in engineering microbiomes? Cell Syst. 2023 02 15; 14(2):85-90. Venturelli OS, Wang HH, Estrela S, Huang KC, Ledesma-Amaro R, Fedorec AJH, Stecher B, Lawson CE, Zarrinpar A, Guo CJ, Soyer OS. PMID: 36796333.
      View in: PubMed   Mentions:    Fields:    
    5. Pre- and Post-Portosystemic Shunt Placement Metabolomics Reveal Molecular Signatures for the Development of Hepatic Encephalopathy. medRxiv. 2023 Jan 04. Dantas Machado AC, Ramos SF, Gauglitz JM, Carpenter AM, Petras D, Aksenov AA, Kim UB, Lazarowicz M, Giustini AB, Aryafar H, Vodkin I, Warren C, Dorrestein PC, Zarrinpar A, Zarrinpar A. PMID: 36711444; PMCID: PMC9882439.
      View in: PubMed   Mentions:
    6. A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites. Nat Commun. 2022 Dec 01; 13(1):7405. De la Paz E, Maganti NH, Trifonov A, Jeerapan I, Mahato K, Yin L, Sonsa-Ard T, Ma N, Jung W, Burns R, Zarrinpar A, Wang J, Mercier PP. PMID: 36456568; PMCID: PMC9715945.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. A high-protein diet prevents weight regain. Nat Metab. 2022 Dec 01. Zarrinpar A. PMID: 36456725.
      View in: PubMed   Mentions:    Fields:    
    8. Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes. Cell. 2022 Aug 18; 185(17):3263-3277.e15. Russell BJ, Brown SD, Siguenza N, Mai I, Saran AR, Lingaraju A, Maissy ES, Dantas Machado AC, Pinto AFM, Sanchez C, Rossitto LA, Miyamoto Y, Richter RA, Ho SB, Eckmann L, Hasty J, Gonzalez DJ, Saghatelian A, Knight R, Zarrinpar A. PMID: 35931082; PMCID: PMC9464905.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    9. Complex physiology and clinical implications of time-restricted eating. Physiol Rev. 2022 10 01; 102(4):1991-2034. Petersen MC, Gallop MR, Flores Ramos S, Zarrinpar A, Broussard JL, Chondronikola M, Chaix A, Klein S. PMID: 35834774; PMCID: PMC9423781.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Cell Rep. 2022 07 05; 40(1):111008. Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. PMID: 35793637; PMCID: PMC9296000.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Candidate probiotic Lactiplantibacillus plantarum HNU082 rapidly and convergently evolves within human, mice, and zebrafish gut but differentially influences the resident microbiome. Microbiome. 2021 06 30; 9(1):151. Huang S, Jiang S, Huo D, Allaband C, Estaki M, Cantu V, Belda-Ferre P, Vázquez-Baeza Y, Zhu Q, Ma C, Li C, Zarrinpar A, Liu YY, Knight R, Zhang J. PMID: 34193290; PMCID: PMC8247228.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    12. Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome. mSystems. 2021 Jun 29; e0011621. Allaband C, Lingaraju A, Martino C, Russell B, Tripathi A, Poulsen O, Dantas Machado AC, Zhou D, Xue J, Elijah E, Malhotra A, Dorrestein PC, Knight R, Haddad GG, Zarrinpar A. PMID: 34184915; PMCID: PMC8269208.
      View in: PubMed   Mentions: 11     Fields:    
    13. Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome. Front Physiol. 2021; 12:663950. Xue J, Allaband C, Zhou D, Poulsen O, Martino C, Jiang L, Tripathi A, Elijah E, Dorrestein PC, Knight R, Zarrinpar A, Haddad GG. PMID: 33897472; PMCID: PMC8060652.
      View in: PubMed   Mentions: 9  
    14. Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease. Gastroenterology. 2020 05; 158(7):1948-1966.e1. Saran AR, Dave S, Zarrinpar A. PMID: 32061597; PMCID: PMC7279714.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    15. Human Skin, Oral, and Gut Microbiomes Predict Chronological Age. mSystems. 2020 Feb 11; 5(1). Huang S, Haiminen N, Carrieri AP, Hu R, Jiang L, Parida L, Russell B, Allaband C, Zarrinpar A, Vázquez-Baeza Y, Belda-Ferre P, Zhou H, Kim HC, Swafford AD, Knight R, Xu ZZ. PMID: 32047061; PMCID: PMC7018528.
      View in: PubMed   Mentions: 37     Fields:    
    16. Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial. Surg Obes Relat Dis. 2019 Aug; 15(8):1348-1354. Thompson CC, Abu Dayyeh BK, Kushnir V, Kushner RF, Jirapinyo P, Schorr AB, Aronne LJ, Amaro A, Jaffe DL, Schulman AR, Early D, Stein AC, Sharaiha R, Edmundowicz SA, Bohning JM, Jensen MD, Shukla AP, Apovian C, Kim DW, Tran D, Zarrinpar A, Ryan MB, Young M, Lowe A, Haas M, Goldsmith H, McCrea J, Sullivan S. PMID: 31302000.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program. Obesity (Silver Spring). 2019 05; 27(5):716-723. Desalermos A, Russell B, Leggett C, Parnell A, Ober K, Hagerich K, Gerlan C, Ganji G, Lee E, Proudfoot JA, Grunvald E, Gupta S, Ho SB, Zarrinpar A. PMID: 31012292; PMCID: PMC6544176.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. The effects of provider-prescribed obesogenic drugs on post-laparoscopic sleeve gastrectomy outcomes: a retrospective cohort study. Int J Obes (Lond). 2019 06; 43(6):1154-1163. Leggett CB, Desalermos A, Brown SD, Lee E, Proudfoot JA, Horgan S, Gupta S, Grunvald E, Ho SB, Zarrinpar A. PMID: 30242239; PMCID: PMC6428627.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894; PMCID: PMC6391518.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    20. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018 07 20; 9(1):2872. Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. PMID: 30030441; PMCID: PMC6054678.
      View in: PubMed   Mentions: 158     Fields:    Translation:Animals
    21. Obesity and response to anti-tumor necrosis factor-α agents in patients with select immune-mediated inflammatory diseases: A systematic review and meta-analysis. PLoS One. 2018; 13(5):e0195123. Singh S, Facciorusso A, Singh AG, Vande Casteele N, Zarrinpar A, Prokop LJ, Grunvald EL, Curtis JR, Sandborn WJ. PMID: 29771924; PMCID: PMC5957395.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    22. High body mass index is associated with increased risk of treatment failure and surgery in biologic-treated patients with ulcerative colitis. Aliment Pharmacol Ther. 2018 06; 47(11):1472-1479. Kurnool S, Nguyen NH, Proudfoot J, Dulai PS, Boland BS, Vande Casteele N, Evans E, Grunvald EL, Zarrinpar A, Sandborn WJ, Singh S. PMID: 29665045; PMCID: PMC5992082.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    23. Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial. Am J Gastroenterol. 2017 03; 112(3):447-457. Thompson CC, Abu Dayyeh BK, Kushner R, Sullivan S, Schorr AB, Amaro A, Apovian CM, Fullum T, Zarrinpar A, Jensen MD, Stein AC, Edmundowicz S, Kahaleh M, Ryou M, Bohning JM, Ginsberg G, Huang C, Tran DD, Glaser JP, Martin JA, Jaffe DL, Farraye FA, Ho SB, Kumar N, Harakal D, Young M, Thomas CE, Shukla AP, Ryan MB, Haas M, Goldsmith H, McCrea J, Aronne LJ. PMID: 27922026; PMCID: PMC5350543.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    24. Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):110-121. Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. PMID: 27899815; PMCID: PMC5550405.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    25. The circadian coordination of cell biology. J Cell Biol. 2016 Oct 10; 215(1):15-25. Chaix A, Zarrinpar A, Panda S. PMID: 27738003; PMCID: PMC5057284.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    26. Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation. Yale J Biol Med. 2016 09; 89(3):383-388. Marotz CA, Zarrinpar A. PMID: 27698622; PMCID: PMC5045147.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    27. Targeting Dysbiosis for the Treatment of Liver Disease. Semin Liver Dis. 2016 Feb; 36(1):37-47. Anand G, Zarrinpar A, Loomba R. PMID: 26870931; PMCID: PMC6658186.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    28. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab. 2016 Feb; 27(2):69-83. Zarrinpar A, Chaix A, Panda S. PMID: 26706567; PMCID: PMC5081399.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    29. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. Gut. 2016 09; 65(9):1546-54. Zarrinpar A, Gupta S, Maurya MR, Subramaniam S, Loomba R. PMID: 26002934; PMCID: PMC5089367.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    30. The effects of time-restricted feeding on lipid metabolism and adiposity. Adipocyte. 2015 Oct-Dec; 4(4):319-24. Chaix A, Zarrinpar A. PMID: 26451290; PMCID: PMC4573188.
      View in: PubMed   Mentions: 10     Fields:    
    31. Video Capsule Endoscopy in Patients with Chronic Abdominal Pain with or without Associated Symptoms: A Retrospective Study. PLoS One. 2015; 10(4):e0126509. Egnatios J, Kaushal K, Kalmaz D, Zarrinpar A. PMID: 25893440; PMCID: PMC4404061.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2015 Sep; 13(9):1625-1632.e1. Frankwich KA, Egnatios J, Kenyon ML, Rutledge TR, Liao PS, Gupta S, Herbst KL, Zarrinpar A. PMID: 25769412; PMCID: PMC4546861.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014 Dec 02; 20(6):991-1005. Chaix A, Zarrinpar A, Miu P, Panda S. PMID: 25470547; PMCID: PMC4255155.
      View in: PubMed   Mentions: 362     Fields:    Translation:Animals
    34. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab. 2014 Dec 02; 20(6):1006-17. Zarrinpar A, Chaix A, Yooseph S, Panda S. PMID: 25470548; PMCID: PMC4255146.
      View in: PubMed   Mentions: 313     Fields:    Translation:Animals
    35. Functional Local Input to Layer 5 Pyramidal Neurons in the Rat Visual Cortex. Cereb Cortex. 2016 Mar; 26(3):991-1003. Zarrinpar A, Callaway EM. PMID: 25405939; PMCID: PMC4737602.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    36. A rare cause of an ileocecal fistula in an AIDS patient. Gastrointestinal infection by Histoplasma capsulatum infection identified with internal transcribed spacer primer sets. Gastroenterology. 2013 Apr; 144(4):697, 857-8. Zarrinpar A, Lin GY, Lonergan JT. PMID: 23499285; PMCID: PMC3648220.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    37. Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2012 Nov; 36(10):909-21. Zarrinpar A, Loomba R. PMID: 23057494; PMCID: PMC3535499.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    38. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 2012 Jun 06; 15(6):848-60. Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, Panda S. PMID: 22608008; PMCID: PMC3491655.
      View in: PubMed   Mentions: 765     Fields:    Translation:AnimalsCells
    39. Local connections to specific types of layer 6 neurons in the rat visual cortex. J Neurophysiol. 2006 Mar; 95(3):1751-61. Zarrinpar A, Callaway EM. PMID: 16319201.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    40. MSJAMA. Quarantine. JAMA. 2003 Dec 03; 290(21):2872. Zarrinpar A. PMID: 14657073.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    41. Do separate processes identify objects as exemplars versus members of basic-level categories? Evidence from hemispheric specialization. Brain Cogn. 2003 Oct; 53(1):15-27. Laeng B, Zarrinpar A, Kosslyn SM. PMID: 14572498.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    42. MSJAMA. Roles for medical students in the political process. JAMA. 2003 Oct 01; 290(13):1774. Zarrinpar A. PMID: 14519714.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Psychiatry and stigmatization. JAMA. 2002 Apr 10; 287(14):1856. Zarrinpar A. PMID: 11939874.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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