Amir Zarrinpar

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    AGA2014  - 2016AGA Microbiome Junior Investigator Research Award
    AASLD2014  - 2017Liver Scholar Award
    Larry L. Hillblom Foundation2014  - 2014Larry L. Hillblom Foundation Award Seed Grant (could not hold with Liver Scholar Award)
    UCSD - CTRI2014  - 2014UCSD KL2 Grant (could not hold with Liver Scholar Award)
    AGA2013  - 2014AGA Elsevier Pilot Research Grant
    Salix Inc.2013  - 2013Fellowship2Leadership Fellow

    Collapse Overview 
    Collapse Overview
    As the health burden of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) increases, I hope to perform high impact research investigating novel therapeutic pathways in these diseases that, as of yet, have few curative options.

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering Native E. coli to Detect, Report, and Treat Colorectal Cancer
    NIH U01CA265719Sep 21, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Design and characterization of bacterial population dynamics in solid tumor models
    NIH R01EB030134Aug 1, 2021 - Apr 30, 2025
    Role: Co-Principal Investigator
    The Role of Altered Luminal Dynamics in OSA-Induced Atherosclerosis
    NIH R01HL148801Jul 10, 2019 - Jun 30, 2024
    Role: Principal Investigator
    The effect of luminal bile acid biotransformations on host cognition
    NIH R21MH117780Jul 1, 2018 - May 31, 2020
    Role: Principal Investigator
    The Effects of Bile Acid Conjugation Through Engineered Probiotics on Gut Luminal signaling and Metabolism
    NIH R03DK114536Aug 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    The Relationship of Gut Microbiome and Time Restricted Feeding in Metabolism
    NIH K08DK102902Sep 30, 2015 - Jul 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Harnessing the power within: engineering the microbiome for enhanced gynecologic health. Reprod Fertil. 2024 Apr 01; 5(2). Brennan C, Chan K, Kumar T, Maissy E, Brubaker L, Dothard MI, Gilbert JA, Gilbert KE, Lewis AL, Thackray VG, Zarrinpar A, Knight R. PMID: 38513356.
      View in: PubMed   Mentions:    Fields:    
    2. Control of Eating Attributes and Weight Loss Outcomes over One Year After Sleeve Gastrectomy. Obes Surg. 2024 Mar 19. Lytvyak E, Zarrinpar A, Dalle Ore C, Lee E, Yazdani-Boset K, Horgan S, Grunvald E. PMID: 38502520.
      View in: PubMed   Mentions:    Fields:    
    3. Live bacterial therapeutics for detection and treatment of colorectal cancer. Nat Rev Gastroenterol Hepatol. 2024 Feb 14. Zhang J, Hasty J, Zarrinpar A. PMID: 38355755.
      View in: PubMed   Mentions:    Fields:    
    4. Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry. Nat Commun. 2023 08 31; 14(1):5303. Dantas Machado AC, Ramos SF, Gauglitz JM, Fassler AM, Petras D, Aksenov AA, Kim UB, Lazarowicz M, Barnard Giustini A, Aryafar H, Vodkin I, Warren C, Dorrestein PC, Zarrinpar A, Zarrinpar A. PMID: 37652904; PMCID: PMC10471626.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Maximizing the potential of high-throughput next-generation sequencing through precise normalization based on read count distribution. mSystems. 2023 08 31; 8(4):e0000623. Brennan C, Salido RA, Belda-Ferre P, Bryant M, Cowart C, Tiu MD, González A, McDonald D, Tribelhorn C, Zarrinpar A, Knight R. PMID: 37350611; PMCID: PMC10469589.
      View in: PubMed   Mentions:    Fields:    
    6. Live Biotherapeutic Products as Cancer Treatments. Cancer Res. 2023 06 15; 83(12):1929-1932. Brevi A, Zarrinpar A. PMID: 37317784; PMCID: PMC10275495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Obesity, Chronic Stress, and Stress Reduction. Gastroenterol Clin North Am. 2023 06; 52(2):347-362. Goens D, Virzi NE, Jung SE, Rutledge TR, Zarrinpar A. PMID: 37197878; PMCID: PMC10746495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Complete Genome Sequence of an Escherichia coli Strain Isolated from Laboratory Mouse Stool for Use as a Chassis for Transgene Delivery to the Murine Microbiome. Microbiol Resour Announc. 2023 Apr 18; 12(4):e0101422. Siguenza N, Russell BJ, Richter RA, Zarrinpar A. PMID: 36856451; PMCID: PMC10112262.
      View in: PubMed   Mentions:
    9. The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases. Gastroenterology. 2023 06; 164(7):1069-1085. Fogelson KA, Dorrestein PC, Zarrinpar A, Knight R. PMID: 36841488; PMCID: PMC10205675.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. What is the key challenge in engineering microbiomes? Cell Syst. 2023 02 15; 14(2):85-90. Venturelli OS, Wang HH, Estrela S, Huang KC, Ledesma-Amaro R, Fedorec AJH, Stecher B, Lawson CE, Zarrinpar A, Guo CJ, Soyer OS. PMID: 36796333.
      View in: PubMed   Mentions: 1     Fields:    
    11. Pre- and Post-Portosystemic Shunt Placement Metabolomics Reveal Molecular Signatures for the Development of Hepatic Encephalopathy. medRxiv. 2023 Jan 04. Dantas Machado AC, Ramos SF, Gauglitz JM, Carpenter AM, Petras D, Aksenov AA, Kim UB, Lazarowicz M, Giustini AB, Aryafar H, Vodkin I, Warren C, Dorrestein PC, Zarrinpar A, Zarrinpar A. PMID: 36711444; PMCID: PMC9882439.
      View in: PubMed   Mentions:
    12. A high-protein diet prevents weight regain. Nat Metab. 2022 Dec 01. Zarrinpar A. PMID: 36456725.
      View in: PubMed   Mentions: 1     Fields:    
    13. A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites. Nat Commun. 2022 Dec 01; 13(1):7405. De la Paz E, Maganti NH, Trifonov A, Jeerapan I, Mahato K, Yin L, Sonsa-Ard T, Ma N, Jung W, Burns R, Zarrinpar A, Wang J, Mercier PP. PMID: 36456568; PMCID: PMC9715945.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    14. Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes. Cell. 2022 08 18; 185(17):3263-3277.e15. Russell BJ, Brown SD, Siguenza N, Mai I, Saran AR, Lingaraju A, Maissy ES, Dantas Machado AC, Pinto AFM, Sanchez C, Rossitto LA, Miyamoto Y, Richter RA, Ho SB, Eckmann L, Hasty J, Gonzalez DJ, Saghatelian A, Knight R, Zarrinpar A. PMID: 35931082; PMCID: PMC9464905.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    15. Complex physiology and clinical implications of time-restricted eating. Physiol Rev. 2022 10 01; 102(4):1991-2034. Petersen MC, Gallop MR, Flores Ramos S, Zarrinpar A, Broussard JL, Chondronikola M, Chaix A, Klein S. PMID: 35834774; PMCID: PMC9423781.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Cell Rep. 2022 07 05; 40(1):111008. Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. PMID: 35793637; PMCID: PMC9296000.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    17. Candidate probiotic Lactiplantibacillus plantarum HNU082 rapidly and convergently evolves within human, mice, and zebrafish gut but differentially influences the resident microbiome. Microbiome. 2021 06 30; 9(1):151. Huang S, Jiang S, Huo D, Allaband C, Estaki M, Cantu V, Belda-Ferre P, Vázquez-Baeza Y, Zhu Q, Ma C, Li C, Zarrinpar A, Liu YY, Knight R, Zhang J. PMID: 34193290; PMCID: PMC8247228.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome. mSystems. 2021 Jun 29; e0011621. Allaband C, Lingaraju A, Martino C, Russell B, Tripathi A, Poulsen O, Dantas Machado AC, Zhou D, Xue J, Elijah E, Malhotra A, Dorrestein PC, Knight R, Haddad GG, Zarrinpar A. PMID: 34184915; PMCID: PMC8269208.
      View in: PubMed   Mentions: 15     Fields:    
    19. Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome. Front Physiol. 2021; 12:663950. Xue J, Allaband C, Zhou D, Poulsen O, Martino C, Jiang L, Tripathi A, Elijah E, Dorrestein PC, Knight R, Zarrinpar A, Haddad GG. PMID: 33897472; PMCID: PMC8060652.
      View in: PubMed   Mentions: 11  
    20. Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease. Gastroenterology. 2020 05; 158(7):1948-1966.e1. Saran AR, Dave S, Zarrinpar A. PMID: 32061597; PMCID: PMC7279714.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    21. Human Skin, Oral, and Gut Microbiomes Predict Chronological Age. mSystems. 2020 Feb 11; 5(1). Huang S, Haiminen N, Carrieri AP, Hu R, Jiang L, Parida L, Russell B, Allaband C, Zarrinpar A, Vázquez-Baeza Y, Belda-Ferre P, Zhou H, Kim HC, Swafford AD, Knight R, Xu ZZ. PMID: 32047061; PMCID: PMC7018528.
      View in: PubMed   Mentions: 51     Fields:    
    22. Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial. Surg Obes Relat Dis. 2019 Aug; 15(8):1348-1354. Thompson CC, Abu Dayyeh BK, Kushnir V, Kushner RF, Jirapinyo P, Schorr AB, Aronne LJ, Amaro A, Jaffe DL, Schulman AR, Early D, Stein AC, Sharaiha R, Edmundowicz SA, Bohning JM, Jensen MD, Shukla AP, Apovian C, Kim DW, Tran D, Zarrinpar A, Ryan MB, Young M, Lowe A, Haas M, Goldsmith H, McCrea J, Sullivan S. PMID: 31302000.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    23. Effect of Obesogenic Medications on Weight-Loss Outcomes in a Behavioral Weight-Management Program. Obesity (Silver Spring). 2019 05; 27(5):716-723. Desalermos A, Russell B, Leggett C, Parnell A, Ober K, Hagerich K, Gerlan C, Ganji G, Lee E, Proudfoot JA, Grunvald E, Gupta S, Ho SB, Zarrinpar A. PMID: 31012292; PMCID: PMC6544176.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. The effects of provider-prescribed obesogenic drugs on post-laparoscopic sleeve gastrectomy outcomes: a retrospective cohort study. Int J Obes (Lond). 2019 06; 43(6):1154-1163. Leggett CB, Desalermos A, Brown SD, Lee E, Proudfoot JA, Horgan S, Gupta S, Grunvald E, Ho SB, Zarrinpar A. PMID: 30242239; PMCID: PMC6428627.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 01; 17(2):218-230. Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. PMID: 30240894; PMCID: PMC6391518.
      View in: PubMed   Mentions: 106     Fields:    Translation:Humans
    26. Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun. 2018 07 20; 9(1):2872. Zarrinpar A, Chaix A, Xu ZZ, Chang MW, Marotz CA, Saghatelian A, Knight R, Panda S. PMID: 30030441; PMCID: PMC6054678.
      View in: PubMed   Mentions: 183     Fields:    Translation:Animals
    27. Obesity and response to anti-tumor necrosis factor-α agents in patients with select immune-mediated inflammatory diseases: A systematic review and meta-analysis. PLoS One. 2018; 13(5):e0195123. Singh S, Facciorusso A, Singh AG, Vande Casteele N, Zarrinpar A, Prokop LJ, Grunvald EL, Curtis JR, Sandborn WJ. PMID: 29771924; PMCID: PMC5957395.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    28. High body mass index is associated with increased risk of treatment failure and surgery in biologic-treated patients with ulcerative colitis. Aliment Pharmacol Ther. 2018 06; 47(11):1472-1479. Kurnool S, Nguyen NH, Proudfoot J, Dulai PS, Boland BS, Vande Casteele N, Evans E, Grunvald EL, Zarrinpar A, Sandborn WJ, Singh S. PMID: 29665045; PMCID: PMC5992082.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    29. Percutaneous Gastrostomy Device for the Treatment of Class II and Class III Obesity: Results of a Randomized Controlled Trial. Am J Gastroenterol. 2017 03; 112(3):447-457. Thompson CC, Abu Dayyeh BK, Kushner R, Sullivan S, Schorr AB, Amaro A, Apovian CM, Fullum T, Zarrinpar A, Jensen MD, Stein AC, Edmundowicz S, Kahaleh M, Ryou M, Bohning JM, Ginsberg G, Huang C, Tran DD, Glaser JP, Martin JA, Jaffe DL, Farraye FA, Ho SB, Kumar N, Harakal D, Young M, Thomas CE, Shukla AP, Ryan MB, Haas M, Goldsmith H, McCrea J, Aronne LJ. PMID: 27922026; PMCID: PMC5350543.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    30. Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):110-121. Singh S, Dulai PS, Zarrinpar A, Ramamoorthy S, Sandborn WJ. PMID: 27899815; PMCID: PMC5550405.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    31. The circadian coordination of cell biology. J Cell Biol. 2016 Oct 10; 215(1):15-25. Chaix A, Zarrinpar A, Panda S. PMID: 27738003; PMCID: PMC5057284.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    32. Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation. Yale J Biol Med. 2016 09; 89(3):383-388. Marotz CA, Zarrinpar A. PMID: 27698622; PMCID: PMC5045147.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    33. Targeting Dysbiosis for the Treatment of Liver Disease. Semin Liver Dis. 2016 Feb; 36(1):37-47. Anand G, Zarrinpar A, Loomba R. PMID: 26870931; PMCID: PMC6658186.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    34. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab. 2016 Feb; 27(2):69-83. Zarrinpar A, Chaix A, Panda S. PMID: 26706567; PMCID: PMC5081399.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimals
    35. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. Gut. 2016 09; 65(9):1546-54. Zarrinpar A, Gupta S, Maurya MR, Subramaniam S, Loomba R. PMID: 26002934; PMCID: PMC5089367.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    36. The effects of time-restricted feeding on lipid metabolism and adiposity. Adipocyte. 2015 Oct-Dec; 4(4):319-24. Chaix A, Zarrinpar A. PMID: 26451290; PMCID: PMC4573188.
      View in: PubMed   Mentions: 9     Fields:    
    37. Video Capsule Endoscopy in Patients with Chronic Abdominal Pain with or without Associated Symptoms: A Retrospective Study. PLoS One. 2015; 10(4):e0126509. Egnatios J, Kaushal K, Kalmaz D, Zarrinpar A. PMID: 25893440; PMCID: PMC4404061.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2015 Sep; 13(9):1625-1632.e1. Frankwich KA, Egnatios J, Kenyon ML, Rutledge TR, Liao PS, Gupta S, Herbst KL, Zarrinpar A. PMID: 25769412; PMCID: PMC4546861.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    39. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. Cell Metab. 2014 Dec 02; 20(6):1006-17. Zarrinpar A, Chaix A, Yooseph S, Panda S. PMID: 25470548; PMCID: PMC4255146.
      View in: PubMed   Mentions: 342     Fields:    Translation:Animals
    40. Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges. Cell Metab. 2014 Dec 02; 20(6):991-1005. Chaix A, Zarrinpar A, Miu P, Panda S. PMID: 25470547; PMCID: PMC4255155.
      View in: PubMed   Mentions: 391     Fields:    Translation:Animals
    41. Functional Local Input to Layer 5 Pyramidal Neurons in the Rat Visual Cortex. Cereb Cortex. 2016 Mar; 26(3):991-1003. Zarrinpar A, Callaway EM. PMID: 25405939; PMCID: PMC4737602.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. A rare cause of an ileocecal fistula in an AIDS patient. Gastrointestinal infection by Histoplasma capsulatum infection identified with internal transcribed spacer primer sets. Gastroenterology. 2013 Apr; 144(4):697, 857-8. Zarrinpar A, Lin GY, Lonergan JT. PMID: 23499285; PMCID: PMC3648220.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    43. Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2012 Nov; 36(10):909-21. Zarrinpar A, Loomba R. PMID: 23057494; PMCID: PMC3535499.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    44. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab. 2012 Jun 06; 15(6):848-60. Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, Panda S. PMID: 22608008; PMCID: PMC3491655.
      View in: PubMed   Mentions: 814     Fields:    Translation:AnimalsCells
    45. Local connections to specific types of layer 6 neurons in the rat visual cortex. J Neurophysiol. 2006 Mar; 95(3):1751-61. Zarrinpar A, Callaway EM. PMID: 16319201.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    46. MSJAMA. Quarantine. JAMA. 2003 Dec 03; 290(21):2872. Zarrinpar A. PMID: 14657073.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    47. Do separate processes identify objects as exemplars versus members of basic-level categories? Evidence from hemispheric specialization. Brain Cogn. 2003 Oct; 53(1):15-27. Laeng B, Zarrinpar A, Kosslyn SM. PMID: 14572498.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    48. MSJAMA. Roles for medical students in the political process. JAMA. 2003 Oct 01; 290(13):1774. Zarrinpar A. PMID: 14519714.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    49. Psychiatry and stigmatization. JAMA. 2002 Apr 10; 287(14):1856. Zarrinpar A. PMID: 11939874.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health