Pradipta Ghosh

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
ORCID ORCID Icon0002-8917-3201 Additional info
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    Other Positions
    Title(s)Cellular and Molecular Medicine


    Collapse Biography 
    Collapse Education and Training
    Christian Medical College & HospitalMBBS (MD)2000Medicine
    Christian Medical College & HospitalResident Physician 2001
    Washington UniversityPostdoctoral2003Cell & Mol Biology
    UC San DiegoInternship Residency2005Internal Medicine
    UC San DiegoFellowship2008Gastroenterology
    UC San DiegoPostdoctoral2008Cell & Mol Biology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Macrophage Polarization in Response to Infections and Inflammation
    NIH R01AI155696Sep 22, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Precision therapeutics of inflammatory bowel disease guided by Boolean logic
    NIH UG3TR003355Aug 28, 2020 - Jul 31, 2023
    Role: Co-Principal Investigator
    Network-Based Novel Therapeutics in Colorectal Cancers
    NIH UG3TR002968Sep 11, 2019 - Jul 31, 2022
    Role: Principal Investigator
    Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal Inflammation
    NIH R01AI141630May 21, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Integrators of Metastatic Potential
    NIH R01CA238042Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator
    G Protein pathways as Novel Therapeutic and Diagnostic Targets in Liver Fibrosis
    NIH R01DK099226Jul 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    Modulation of G proteins by Growth Factors
    NIH R01CA160911Feb 1, 2013 - Jan 31, 2020
    Role: Principal Investigator
    Spatial Regulation of RGS and G Protein Signaling
    NIH R01CA100768Apr 17, 2003 - Jan 31, 2021
    Role: Principal Investigator
    Training Grant in Gastroenterology
    NIH T32DK007202Jul 1, 1976 - Jun 30, 2023
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Interlinked switch circuits of biological intelligence. Trends Biochem Sci. 2024 Feb 09. Mukherjee R, Sinha S, Luker GD, Ghosh P. PMID: 38341333.
      View in: PubMed   Mentions:    Fields:    
    2. Growth signaling autonomy in circulating tumor cells aids metastatic seeding. PNAS Nexus. 2024 Feb; 3(2):pgae014. Sinha S, Farfel A, Luker KE, Parker BA, Yeung KT, Luker GD, Ghosh P. PMID: 38312224; PMCID: PMC10833458.
      View in: PubMed   Mentions:
    3. Macrophage states: there's a method in the madness. Trends Immunol. 2023 Dec; 44(12):954-964. Katkar G, Ghosh P. PMID: 37945504.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism. J Biol Chem. 2023 Dec; 299(12):105390. Anandachar MS, Roy S, Sinha S, Boadi A, Katkar GD, Ghosh P. PMID: 37890785; PMCID: PMC10696401.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2024 01; 293:701-708. Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. PMID: 37839102.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Sci Alliance. 2023 11; 6(11). Hernandez JE, Llorente C, Ma S, Miyamoto KT, Sinha S, Steele S, Xiao Z, Lai CJ, Zuniga EI, Ghosh P, Schnabl B, Huang WJM. PMID: 37666668; PMCID: PMC10477432.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes. EBioMedicine. 2023 Aug; 94:104719. Ghosh P, Sinha S, Katkar GD, Vo D, Taheri S, Dang D, Das S, Sahoo D. PMID: 37516087; PMCID: PMC10388732.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. Curr Issues Mol Biol. 2023 Apr 11; 45(4):3347-3358. Turner MA, Cox KE, Liu S, Neel N, Amirfakhri S, Nishino H, Hosseini M, Alcantara JA, Abd El-Hafeez AA, Lwin TM, Mallya K, Pisegna JR, Singh SK, Ghosh P, Hoffman RM, Batra SK, Bouvet M. PMID: 37185743; PMCID: PMC10136452.
      View in: PubMed   Mentions:    Fields:    
    9. A circuit for secretion-coupled cellular autonomy in multicellular eukaryotic cells. Mol Syst Biol. 2023 04 12; 19(4):e11127. Qiao L, Sinha S, Abd El-Hafeez AA, Lo IC, Midde KK, Ngo T, Aznar N, Lopez-Sanchez I, Gupta V, Farquhar MG, Rangamani P, Ghosh P. PMID: 36856068; PMCID: PMC10090951.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. Identification of a novel gene signature for neuroblastoma differentiation using a Boolean implication network. Genes Chromosomes Cancer. 2023 06; 62(6):313-331. Zage PE, Huo Y, Subramonian D, Le Clorennec C, Ghosh P, Sahoo D. PMID: 36680522; PMCID: PMC10257350.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Design principles of improving the dose-response alignment in coupled GTPase switches. NPJ Syst Biol Appl. 2023 01 31; 9(1):3. Qiao L, Ghosh P, Rangamani P. PMID: 36720885; PMCID: PMC9889403.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. Artificial intelligence-guided discovery of gastric cancer continuum. Gastric Cancer. 2023 03; 26(2):286-297. Vo D, Ghosh P, Sahoo D. PMID: 36692601; PMCID: PMC9871434.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Regulation of DNA damage response by trimeric G-proteins. iScience. 2023 Feb 17; 26(2):105973. Abd El-Hafeez AA, Sun N, Chakraborty A, Ear J, Roy S, Chamarthi P, Rajapakse N, Das S, Luker KE, Hazra TK, Luker GD, Ghosh P. PMID: 36756378; PMCID: PMC9900518.
      View in: PubMed   Mentions: 2  
    14. Publisher Correction: An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nat Commun. 2022 Aug 11; 13(1):4729. Ghosh P, Katkar GD, Shimizu C, Kim J, Khandelwal S, Tremoulet AH, Kanegaye JT, Pediatric Emergency Medicine Kawasaki Disease Research Group, Bocchini J, Das S, Burns JC, Sahoo D. PMID: 35953486; PMCID: PMC9372045.
      View in: PubMed   Mentions:    Fields:    
    15. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. EBioMedicine. 2022 Aug; 82:104185. Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P. PMID: 35870428; PMCID: PMC9297827.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nat Commun. 2022 05 16; 13(1):2687. Ghosh P, Katkar GD, Shimizu C, Kim J, Khandelwal S, Tremoulet AH, Kanegaye JT, Pediatric Emergency Medicine Kawasaki Disease Research Group, Bocchini J, Das S, Burns JC, Sahoo D. PMID: 35577777; PMCID: PMC9110726.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCellsPHPublic Health
    17. The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. Cell Mol Gastroenterol Hepatol. 2022; 14(1):35-53. Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. PMID: 35378331; PMCID: PMC9117812.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    18. Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease. Commun Biol. 2022 03 14; 5(1):231. Katkar GD, Sayed IM, Anandachar MS, Castillo V, Vidales E, Toobian D, Usmani F, Sawires JR, Leriche G, Yang J, Sandborn WJ, Das S, Sahoo D, Ghosh P. PMID: 35288651; PMCID: PMC8921270.
      View in: PubMed   Mentions: 4  Translation:HumansAnimalsCells
    19. Parsing the Role of PPARs in Macrophage Processes. Front Immunol. 2021; 12:783780. Toobian D, Ghosh P, Katkar GD. PMID: 35003101; PMCID: PMC8727354.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    20. RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut. 2022 09; 71(9):1790-1802. Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo GW, Telese F, Ghosh P, Das S, Huang WJM. PMID: 34853057; PMCID: PMC9156727.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    21. SPT6 loss permits the transdifferentiation of keratinocytes into an intestinal fate that resembles Barrett's metaplasia. iScience. 2021 Oct 22; 24(10):103121. Vo DT, Fuller MR, Tindle C, Anandachar MS, Das S, Sahoo D, Ghosh P. PMID: 34622168; PMCID: PMC8481972.
      View in: PubMed   Mentions: 3  
    22. GIV/Girdin, a non-receptor modulator for Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is required for male fertility. Elife. 2021 08 19; 10. Reynoso S, Castillo V, Katkar GD, Lopez-Sanchez I, Taheri S, Espinoza C, Rohena C, Sahoo D, Gagneux P, Ghosh P. PMID: 34409938; PMCID: PMC8376251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19. Elife. 2021 08 13; 10. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar GD, Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das S. PMID: 34463615; PMCID: PMC8463074.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    24. Functional assays with human patient-derived enteroid monolayers to assess the human gut barrier. STAR Protoc. 2021 09 17; 2(3):100680. Sayed IM, Tindle C, Fonseca AG, Ghosh P, Das S. PMID: 34337445; PMCID: PMC8313751.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease. Nat Commun. 2021 07 12; 12(1):4246. Sahoo D, Swanson L, Sayed IM, Katkar GD, Ibeawuchi SR, Mittal Y, Pranadinata RF, Tindle C, Fuller M, Stec DL, Chang JT, Sandborn WJ, Das S, Ghosh P. PMID: 34253728; PMCID: PMC8275683.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    26. AI-guided discovery of the invariant host response to viral pandemics. EBioMedicine. 2021 Jun; 68:103390. Sahoo D, Katkar GD, Khandelwal S, Behroozikhah M, Claire A, Castillo V, Tindle C, Fuller M, Taheri S, Rogers TF, Beutler N, Ramirez SI, Rawlings SA, Pretorius V, Smith DM, Burton DR, Alexander LEC, Duran J, Crotty S, Dan JM, Das S, Ghosh P. PMID: 34127431; PMCID: PMC8193764.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsPHPublic Health
    27. Building unconventional G protein-coupled receptors, one block at a time. Trends Pharmacol Sci. 2021 07; 42(7):514-517. Ghosh P, Mullick M. PMID: 33985816; PMCID: PMC8779748.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    28. Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin). Hypertension. 2021 05 05; 77(5):1670-1682. Ying W, Tang K, Avolio E, Schilling JM, Pasqua T, Liu MA, Cheng H, Gao H, Zhang J, Mahata S, Ko MS, Bandyopadhyay G, Das S, Roth DM, Sahoo D, Webster NJG, Sheikh F, Ghosh G, Patel HH, Ghosh P, van den Bogaart G, Mahata SK. PMID: 33826401; PMCID: PMC8116433.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Modeling colorectal cancers using multidimensional organoids. Adv Cancer Res. 2021; 151:345-383. Sayed IM, El-Hafeez AAA, Maity PP, Das S, Ghosh P. PMID: 34148617; PMCID: PMC8221168.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding. J Biol Chem. 2021 Jan-Jun; 296:100493. Ear J, Abd El-Hafeez AA, Roy S, Ngo T, Rajapakse N, Choi J, Khandelwal S, Ghassemian M, McCaffrey L, Kufareva I, Sahoo D, Ghosh P. PMID: 33675748; PMCID: PMC8042451.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Stability Analysis of a Signaling Circuit with Dual Species of GTPase Switches. Bull Math Biol. 2021 02 20; 83(4):34. Stolerman LM, Ghosh P, Rangamani P. PMID: 33609194; PMCID: PMC8378325.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. Nat Commun. 2021 02 04; 12(1):784. Li J, Xu X, Tiwari M, Chen Y, Fuller M, Bansal V, Tamayo P, Das S, Ghosh P, Sen GL. PMID: 33542242; PMCID: PMC7862286.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. E-cigarettes compromise the gut barrier and trigger inflammation. iScience. 2021 Feb 19; 24(2):102035. Sharma A, Lee J, Fonseca AG, Moshensky A, Kothari T, Sayed IM, Ibeawuchi SR, Pranadinata RF, Ear J, Sahoo D, Crotty-Alexander LE, Ghosh P, Das S. PMID: 33537654; PMCID: PMC7841355.
      View in: PubMed   Mentions: 18  
    34. Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28763-28774. Kalogriopoulos NA, Lopez-Sanchez I, Lin C, Ngo T, Midde KK, Roy S, Aznar N, Murray F, Garcia-Marcos M, Kufareva I, Ghassemian M, Ghosh P. PMID: 33139573; PMCID: PMC7682395.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    35. TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci U S A. 2020 10 27; 117(43):26895-26906. Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P. PMID: 33055214; PMCID: PMC7604444.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    36. The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells. Cells. 2020 08 28; 9(9). Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32872214; PMCID: PMC7565382.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    37. DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis. Life Sci Alliance. 2020 10; 3(10). Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. PMID: 32817263; PMCID: PMC7441524.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells. J Biol Chem. 2020 08 07; 295(32):11082-11098. Sayed IM, Sahan AZ, Venkova T, Chakraborty A, Mukhopadhyay D, Bimczok D, Beswick EJ, Reyes VE, Pinchuk I, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32518160; PMCID: PMC7415988.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    39. GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery. iScience. 2020 Jul 24; 23(7):101246. Rohena C, Rajapakse N, Lo IC, Novick P, Sahoo D, Ghosh P. PMID: 32590327; PMCID: PMC7322189.
      View in: PubMed   Mentions: 1  
    40. GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation. iScience. 2020 Jun 26; 23(6):101209. Rohena C, Kalogriopoulos N, Rajapakse N, Roy S, Lopez-Sanchez I, Ablack J, Sahoo D, Ghosh P. PMID: 32535026; PMCID: PMC7300163.
      View in: PubMed   Mentions: 6  
    41. Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves". Wiley Interdiscip Rev Syst Biol Med. 2020 09; 12(5):e1490. Getz M, Rangamani P, Ghosh P. PMID: 32323924; PMCID: PMC7581534.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    42. Computational Approach to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020; 11:275. Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. PMID: 32322218; PMCID: PMC7156600.
      View in: PubMed   Mentions: 12  
    43. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 09; 287(18):3967-3988. Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. PMID: 32003126; PMCID: PMC7390677.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. Life Sci Alliance. 2020 03; 3(3). Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S. PMID: 32041849; PMCID: PMC7012149.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    45. Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions. iScience. 2020 Feb 21; 23(2):100859. Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, Ghosh P. PMID: 32058970; PMCID: PMC7005484.
      View in: PubMed   Mentions: 6  
    46. Do All Roads Lead to Rome in G-Protein Activation? Trends Biochem Sci. 2020 03; 45(3):182-184. Ghosh P, Garcia-Marcos M. PMID: 31753703; PMCID: PMC7147754.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    47. Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes. Clin Transl Gastroenterol. 2019 11; 10(11):e00092. Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S. PMID: 31770138; PMCID: PMC6890275.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant. Acta Neuropathol. 2019 10; 138(4):671-672. Saha S, Siddiqui SS, Khan N, Verhagen A, Jiang W, Springer S, Ghosh P, Varki A. PMID: 31440824.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    49. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 08 20; 9(1):12124. Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. PMID: 31431650; PMCID: PMC6702192.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    50. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403. Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. PMID: 31363053; PMCID: PMC6697900.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    51. A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. Mol Biol Cell. 2019 06 15; 30(13):1621-1633. Getz M, Swanson L, Sahoo D, Ghosh P, Rangamani P. PMID: 31017840; PMCID: PMC6727633.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    52. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 12 21; 8(1):18036. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P. PMID: 30575751; PMCID: PMC6303298.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    53. Single-Cell Imaging of Metastatic Potential of Cancer Cells. iScience. 2018 Dec 21; 10:53-65. Midde K, Sun N, Rohena C, Joosen L, Dhillon H, Ghosh P. PMID: 30500482; PMCID: PMC6263091.
      View in: PubMed   Mentions: 9  
    54. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 02 27; 11(519). Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. PMID: 29487190; PMCID: PMC5862031.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    55. A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. Mol Biol Cell. 2017 Dec 01; 28(25):3709-3723. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. PMID: 29021338; PMCID: PMC5706997.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    56. The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block. Cell Cycle. 2017 Apr 03; 16(7):607-612. Ghosh P, Rangamani P, Kufareva I. PMID: 28287365; PMCID: PMC5397260.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    57. The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults. Aging (Albany NY). 2017 02 15; 9(2):303-314. Ghosh P. PMID: 28209925; PMCID: PMC5361665.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    58. Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):265-298. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. PMID: 27925669; PMCID: PMC5154557.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    59. AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. Elife. 2016 11 04; 5. Aznar N, Patel A, Rohena CC, Dunkel Y, Joosen LP, Taupin V, Kufareva I, Farquhar MG, Ghosh P. PMID: 27813479; PMCID: PMC5119889.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    60. GIV/Girdin activates Gαi and inhibits Gαs via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. PMID: 27621449; PMCID: PMC5047194.
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    61. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth. Neoplasia. 2016 05; 18(5):294-306. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga EI, Fuster MM. PMID: 27237321; PMCID: PMC4887599.
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    62. Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer. Clin Cancer Res. 2016 07 15; 22(14):3488-98. Ghosh P, Tie J, Muranyi A, Singh S, Brunhoeber P, Leith K, Bowermaster R, Liao Z, Zhu Y, LaFleur B, Tran B, Desai J, Jones I, Croxford M, Jover R, Goel A, Waring P, Hu S, Teichgraber V, Rohr UP, Ridder R, Shanmugam K, Gibbs P. PMID: 27029492; PMCID: PMC4947424.
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    63. Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time. Bioessays. 2016 Apr; 38(4):379-93. Aznar N, Kalogriopoulos N, Midde KK, Ghosh P. PMID: 26879989; PMCID: PMC5123561.
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    64. The untapped potential of tyrosine-based G protein signaling. Pharmacol Res. 2016 Mar; 105:99-107. Ghosh P. PMID: 26808081; PMCID: PMC4775314.
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    65. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015 Dec 4-11; 468(1-2):287-93. Lopez-Sanchez I, Ma GS, Pedram S, Kalogriopoulos N, Ghosh P. PMID: 26514725; PMCID: PMC4659757.
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    66. Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins. Mol Biol Cell. 2015 Dec 01; 26(24):4313-24. Lopez-Sanchez I, Kalogriopoulos N, Lo IC, Kabir F, Midde KK, Wang H, Ghosh P. PMID: 26446841; PMCID: PMC4666128.
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    67. Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. Mol Biol Cell. 2015 Nov 15; 26(23):4209-23. Ma GS, Lopez-Sanchez I, Aznar N, Kalogriopoulos N, Pedram S, Midde K, Ciaraldi TP, Henry RR, Ghosh P. PMID: 26378251; PMCID: PMC4642855.
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    68. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4874-83. Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. PMID: 26286990; PMCID: PMC4568279.
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    69. Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra. Aging (Albany NY). 2015 Jul; 7(7):469-74. Ghosh P. PMID: 26224586; PMCID: PMC4543036.
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    70. G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron. Cell Cycle. 2015; 14(16):2561-5. Ghosh P. PMID: 26126131; PMCID: PMC4613836.
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    71. Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife. 2015 Jun 30; 4:e07091. Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P. PMID: 26126266; PMCID: PMC4484057.
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    72. Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2602-10. Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. PMID: 25926659; PMCID: PMC4443320.
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    73. Activation of Gαi at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling. Dev Cell. 2015 Apr 20; 33(2):189-203. Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P. PMID: 25865347; PMCID: PMC4415880.
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    74. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 05; 25(22):3654-71. Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. PMID: 25187647; PMCID: PMC4230624.
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    75. Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(7):53. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 25228923; PMCID: PMC4165363.
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    76. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. PMID: 25043713; PMCID: PMC4107319.
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    77. Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(5):43. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 24944587; PMCID: PMC4062050.
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    78. Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5510-5. López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. PMID: 23509302; PMCID: PMC3619294.
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    79. STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem. 2012 Dec 07; 287(50):41667-83. Dunkel Y, Ong A, Notani D, Mittal Y, Lam M, Mi X, Ghosh P. PMID: 23066027; PMCID: PMC3516717.
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    80. Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1961-6. Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG. PMID: 22308453; PMCID: PMC3277514.
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    81. Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. PMID: 21954290; PMCID: PMC4226136.
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    82. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem. 2011 Sep 16; 286(37):32404-15. Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. PMID: 21799016; PMCID: PMC3173146.
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    83. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem. 2011 Aug 12; 286(32):28138-49. Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG. PMID: 21653697; PMCID: PMC3151059.
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    84. Sequential interactions with Sec23 control the direction of vesicle traffic. Nature. 2011 May 12; 473(7346):181-6. Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S. PMID: 21532587; PMCID: PMC3093450.
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    85. GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr. 2011 May-Jun; 5(3):237-48. Ghosh P, Garcia-Marcos M, Farquhar MG. PMID: 21546796; PMCID: PMC3210208.
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    86. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 01; 22(5):673-86. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. PMID: 21209316; PMCID: PMC3046063.
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    87. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. PMID: 20974669; PMCID: PMC3023389.
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    88. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 01; 21(13):2338-54. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. PMID: 20462955; PMCID: PMC2893996.
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    89. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23; 285(17):12765-77. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. PMID: 20157114; PMCID: PMC2857069.
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    90. ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding. Gastroenterol Res Pract. 2009; 2009:384506. Lee JK, Carethers JM, Ghosh P. PMID: 19753317; PMCID: PMC2742646.
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    91. Generalized megaviscera of lupus: refractory intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus. World J Gastroenterol. 2009 Jul 28; 15(28):3555-9. Park FD, Lee JK, Madduri GD, Ghosh P. PMID: 19630114; PMCID: PMC2715985.
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    92. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3178-83. Garcia-Marcos M, Ghosh P, Farquhar MG. PMID: 19211784; PMCID: PMC2651282.
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    93. Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008 Jul 28; 182(2):381-93. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. PMID: 18663145; PMCID: PMC2483528.
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    94. Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma. World J Gastroenterol. 2008 Jul 21; 14(27):4389-94. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S, Carethers JM. PMID: 18666331; PMCID: PMC2731194.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    95. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14; 13(6):960-3. Ghosh P, Miyai K, Chojkier M. PMID: 17352032; PMCID: PMC4065938.
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    96. Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007 May; 5(5):A32. Ghosh P, Kum J. PMID: 17261382.
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    97. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature. J Clin Gastroenterol. 2006 May-Jun; 40(5):427-30. Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. PMID: 16721225.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans