Loading...

Pradipta Ghosh

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Address9500 Gilman Drive #0651
La Jolla CA 92093
Phone858-822-7633
vCardDownload vCard
    Other Positions
    Title(s)Cellular and Molecular Medicine


    Collapse Biography 
    Collapse Education and Training
    Christian Medical College & HospitalMBBS (MD)2000Medicine
    Christian Medical College & HospitalResident Physician 2001
    Washington UniversityPostdoctoral2003Cell & Mol Biology
    UC San DiegoInternship Residency2005Internal Medicine
    UC San DiegoFellowship2008Gastroenterology
    UC San DiegoPostdoctoral2008Cell & Mol Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Network-Based Novel Therapeutics in Colorectal Cancers
    NIH/NCATS UG3TR002968Sep 11, 2019 - Jul 31, 2022
    Role: Principal Investigator
    Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal Inflammation
    NIH/NIAID R01AI141630May 21, 2019 - Apr 30, 2024
    Role: Principal Investigator
    Integrators of Metastatic Potential
    NIH/NCI R01CA238042Mar 1, 2019 - Feb 29, 2024
    Role: Principal Investigator
    G Protein pathways as Novel Therapeutic and Diagnostic Targets in Liver Fibrosis
    NIH/NIDDK R01DK099226Jul 1, 2014 - Jun 30, 2017
    Role: Principal Investigator
    Modulation of G proteins by Growth Factors
    NIH/NCI R01CA160911Feb 1, 2013 - Jan 31, 2018
    Role: Principal Investigator
    Spatial Regulation of RGS and G Protein Signaling
    NIH/NCI R01CA100768Apr 17, 2003 - May 31, 2014
    Role: Principal Investigator
    Training Grant in Gastroenterology
    NIH/NIDDK T32DK007202Jul 1, 1976 - Mar 31, 1992
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Helicobacter pylori infection down-regulates the DNA glycosylase NEIL2,  resulting in increased genome damage and inflammation in gastric epithelial cells. J Biol Chem. 2020 Jun 09. Sayed IM, Sahan AZ, Venkova T, Chakraborty A, Mukhopadhyay D, Bimczok D, Beswick EJ, Reyes VE, Pinchuk I, Sahoo D, Ghosh P, Hazra TK, Das S. PMID: 32518160.
      View in: PubMed   Mentions:    Fields:    
    2. Enhanced mitochondrial fission suppresses signaling and metastasis in triple-negative breast cancer. Breast Cancer Res. 2020 Jun 05; 22(1):60. Humphries BA, Cutter AC, Buschhaus JM, Chen YC, Qyli T, Palagama DSW, Eckley S, Robison TH, Bevoor A, Chiang B, Haley HR, Sahoo S, Spinosa PC, Neale DB, Boppisetti J, Sahoo D, Ghosh P, Lahann J, Ross BD, Yoon E, Luker KE, Luker GD. PMID: 32503622.
      View in: PubMed   Mentions:    Fields:    
    3. Regulating cellular cyclic adenosine monophosphate: "Sources," "sinks," and now, "tunable valves". Wiley Interdiscip Rev Syst Biol Med. 2020 Apr 23; e1490. Getz M, Rangamani P, Ghosh P. PMID: 32323924.
      View in: PubMed   Mentions:    Fields:    
    4. Computational Approach to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020; 11:275. Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. PMID: 32322218.
      View in: PubMed   Mentions:
    5. The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. Life Sci Alliance. 2020 03; 3(3). Ghosh P, Swanson L, Sayed IM, Mittal Y, Lim BB, Ibeawuchi SR, Foretz M, Viollet B, Sahoo D, Das S. PMID: 32041849.
      View in: PubMed   Mentions:    Fields:    
    6. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 Jan 30. Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. PMID: 32003126.
      View in: PubMed   Mentions:    Fields:    
    7. Tyrosine-Based Signals Regulate the Assembly of Daple·PARD3 Complex at Cell-Cell Junctions. iScience. 2020 Feb 21; 23(2):100859. Ear J, Saklecha A, Rajapakse N, Choi J, Ghassemian M, Kufareva I, Ghosh P. PMID: 32058970.
      View in: PubMed   Mentions:
    8. DAPLE protein inhibits nucleotide exchange on Gas and Gaq via the same motif that activates Gai. J Biol Chem. 2020 Feb 21; 295(8):2270-2284. Marivin A, Maziarz M, Zhao J, DiGiacomo V, Olmos Calvo I, Mann EA, Ear J, Blanco-Canosa JB, Ross EM, Ghosh P, Garcia-Marcos M. PMID: 31949046.
      View in: PubMed   Mentions:    Fields:    
    9. The Ga-interacting vesicle-associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress. FEBS Lett. 2020 Mar; 594(6):1088-1100. Limso C, Ngo JM, Nguyen P, Leal S, Husain A, Sahoo D, Ghosh P, Bhandari D. PMID: 31736058.
      View in: PubMed   Mentions:    Fields:    
    10. Do All Roads Lead to Rome in G-Protein Activation? Trends Biochem Sci. 2020 Mar; 45(3):182-184. Ghosh P, Garcia-Marcos M. PMID: 31753703.
      View in: PubMed   Mentions:    Fields:    
    11. Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes. Clin Transl Gastroenterol. 2019 11; 10(11):e00092. Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS, Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S. PMID: 31770138.
      View in: PubMed   Mentions:    Fields:    
    12. Novel candidates in early-onset familial colorectal cancer. Fam Cancer. 2020 Jan; 19(1):1-10. Jansen AML, Ghosh P, Dakal TC, Slavin TP, Boland CR, Goel A. PMID: 31555933.
      View in: PubMed   Mentions:    Fields:    
    13. Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant. Acta Neuropathol. 2019 10; 138(4):671-672. Saha S, Siddiqui SS, Khan N, Verhagen A, Jiang W, Springer S, Ghosh P, Varki A. PMID: 31440824.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 08 20; 9(1):12124. Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. PMID: 31431650.
      View in: PubMed   Mentions: 1     Fields:    
    15. Structural basis for GPCR-independent activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16394-16403. Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I. PMID: 31363053.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. A predictive computational model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated cyclic AMP signals. Mol Biol Cell. 2019 06 15; 30(13):1621-1633. Getz M, Swanson L, Sahoo D, Ghosh P, Rangamani P. PMID: 31017840.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Near-Infrared Light-Activated DNA-Agonist Nanodevice for Nongenetically and Remotely Controlled Cellular Signaling and Behaviors in Live Animals. Nano Lett. 2019 04 10; 19(4):2603-2613. Wang M, He F, Li H, Yang S, Zhang J, Ghosh P, Wang HH, Nie Z. PMID: 30907088.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 12 21; 8(1):18036. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, Ghosh P. PMID: 30575751.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Single-Cell Imaging of Metastatic Potential of Cancer Cells. iScience. 2018 Dec 21; 10:53-65. Midde K, Sun N, Rohena C, Joosen L, Dhillon H, Ghosh P. PMID: 30500482.
      View in: PubMed   Mentions:
    20. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018 02 27; 11(519). Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA, Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. PMID: 29487190.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing ß-catenin. Mol Biol Cell. 2017 Dec 01; 28(25):3709-3723. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. PMID: 29021338.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. J Biol Chem. 2017 09 15; 292(37):15312-15320. Siddiqui SS, Springer SA, Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang W, Ghosh P, Varki A. PMID: 28747436.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation. Blood. 2017 06 08; 129(23):3100-3110. Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P, Deng L, Nizet V, Varki A. PMID: 28416510.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block. Cell Cycle. 2017 Apr 03; 16(7):607-612. Ghosh P, Rangamani P, Kufareva I. PMID: 28287365.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. The stress polarity pathway: AMPK 'GIV'-es protection against metabolic insults. Aging (Albany NY). 2017 02 15; 9(2):303-314. Ghosh P. PMID: 28209925.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 07; 8(4):265-298. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C, Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. PMID: 27925669.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin. Elife. 2016 11 04; 5. Aznar N, Patel A, Rohena CC, Dunkel Y, Joosen LP, Taupin V, Kufareva I, Farquhar MG, Ghosh P. PMID: 27813479.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. GIV/Girdin activates Gai and inhibits Gas via the same motif. Proc Natl Acad Sci U S A. 2016 09 27; 113(39):E5721-30. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. PMID: 27621449.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. Mitochondrial BMI1 maintains bioenergetic homeostasis in cells. FASEB J. 2016 12; 30(12):4042-4055. Banerjee Mustafi S, Aznar N, Dwivedi SK, Chakraborty PK, Basak R, Mukherjee P, Ghosh P, Bhattacharya R. PMID: 27613804.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers. FASEB J. 2016 11; 30(11):3702-3713. Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, Mi XY, Ghosh P. PMID: 27440794.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth. Neoplasia. 2016 05; 18(5):294-306. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga EI, Fuster MM. PMID: 27237321.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Girdin (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-Proficient Stage II Colon Cancer. Clin Cancer Res. 2016 07 15; 22(14):3488-98. Ghosh P, Tie J, Muranyi A, Singh S, Brunhoeber P, Leith K, Bowermaster R, Liao Z, Zhu Y, LaFleur B, Tran B, Desai J, Jones I, Croxford M, Jover R, Goel A, Waring P, Hu S, Teichgraber V, Rohr UP, Ridder R, Shanmugam K, Gibbs P. PMID: 27029492.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer. Sci Rep. 2016 Feb 26; 6:22112. Barbazan J, Dunkel Y, Li H, Nitsche U, Janssen KP, Messer K, Ghosh P. PMID: 26916336.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time. Bioessays. 2016 Apr; 38(4):379-93. Aznar N, Kalogriopoulos N, Midde KK, Ghosh P. PMID: 26879989.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    35. The untapped potential of tyrosine-based G protein signaling. Pharmacol Res. 2016 Mar; 105:99-107. Ghosh P. PMID: 26808081.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun. 2015 Dec 4-11; 468(1-2):287-93. Lopez-Sanchez I, Ma GS, Pedram S, Kalogriopoulos N, Ghosh P. PMID: 26514725.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    37. Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins. Mol Biol Cell. 2015 Dec 01; 26(24):4313-24. Lopez-Sanchez I, Kalogriopoulos N, Lo IC, Kabir F, Midde KK, Wang H, Ghosh P. PMID: 26446841.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. Mol Biol Cell. 2015 Nov 15; 26(23):4209-23. Ma GS, Lopez-Sanchez I, Aznar N, Kalogriopoulos N, Pedram S, Midde K, Ciaraldi TP, Henry RR, Ghosh P. PMID: 26378251.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):E4874-83. Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. PMID: 26286990.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a Hydra. Aging (Albany NY). 2015 Jul; 7(7):469-74. Ghosh P. PMID: 26224586.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife. 2015 Jun 30; 4:e07091. Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P. PMID: 26126266.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    42. G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron. Cell Cycle. 2015; 14(16):2561-5. Ghosh P. PMID: 26126131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    43. Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2602-10. Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel Y, Gallo RL, Ghosh P. PMID: 25926659.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    44. Activation of Gai at the Golgi by GIV/Girdin imposes finiteness in Arf1 signaling. Dev Cell. 2015 Apr 20; 33(2):189-203. Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R, Randazzo PA, Farquhar MG, Ghosh P. PMID: 25865347.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    45. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):E937-46. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P. PMID: 25713130.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    46. GIV/Girdin transmits signals from multiple receptors by triggering trimeric G protein activation. J Biol Chem. 2015 Mar 13; 290(11):6697-704. Garcia-Marcos M, Ghosh P, Farquhar MG. PMID: 25605737.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    47. Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov 05; 25(22):3654-71. Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I, Abagyan R, Ghosh P. PMID: 25187647.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    48. Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(7):53. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 25228923.
      View in: PubMed   Mentions:    Fields:    
    49. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. PMID: 25043713.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    50. GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. J Am Soc Nephrol. 2015 Feb; 26(2):314-27. Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG. PMID: 25012178.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    51. Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(5):43. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 24944587.
      View in: PubMed   Mentions: 15     Fields:    
    52. Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth. Clin Cancer Res. 2014 Jan 01; 20(1):199-212. Karkare S, Chhipa RR, Anderson J, Liu X, Henry H, Gasilina A, Nassar N, Ghosh J, Clark JP, Kumar A, Pauletti GM, Ghosh PK, Dasgupta B. PMID: 24170547.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    53. Protein kinase C-theta (PKC?) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5510-5. López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. PMID: 23509302.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    54. STAT3 protein up-regulates Ga-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis. J Biol Chem. 2012 Dec 07; 287(50):41667-83. Dunkel Y, Ong A, Notani D, Mittal Y, Lam M, Mi X, Ghosh P. PMID: 23066027.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    55. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. PMID: 22966490.
      View in: PubMed   Mentions: 1430     Fields:    Translation:HumansAnimals
    56. Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1961-6. Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG. PMID: 22308453.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    57. Tyrosine phosphorylation of the Ga-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci Signal. 2011 Sep 27; 4(192):ra64. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R, Garcia-Marcos M, Ghosh P. PMID: 21954290.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    58. Phosphorylation of podocalyxin (Ser415) Prevents RhoA and ezrin activation and disrupts its interaction with the actin cytoskeleton. Am J Pathol. 2011 Nov; 179(5):2254-65. Fukasawa H, Obayashi H, Schmieder S, Lee J, Ghosh P, Farquhar MG. PMID: 21945805.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    59. Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem. 2011 Sep 16; 286(37):32404-15. Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. PMID: 21799016.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs. J Biol Chem. 2011 Aug 12; 286(32):28138-49. Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG. PMID: 21653697.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    61. Sequential interactions with Sec23 control the direction of vesicle traffic. Nature. 2011 May 12; 473(7346):181-6. Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S. PMID: 21532587.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    62. GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adh Migr. 2011 May-Jun; 5(3):237-48. Ghosh P, Garcia-Marcos M, Farquhar MG. PMID: 21546796.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    63. A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals. Mol Biol Cell. 2011 Mar 01; 22(5):673-86. Garcia-Marcos M, Ear J, Farquhar MG, Ghosh P. PMID: 21209316.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    64. Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer. FASEB J. 2011 Feb; 25(2):590-9. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. PMID: 20974669.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    65. Achalasia, alcohol-stasis, and acute necrotizing esophagitis: connecting the dots. Dig Dis Sci. 2011 Feb; 56(2):612-4. Lee JK, Bhargava V, Mittal RK, Ghosh P. PMID: 20552400.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    66. A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate. Mol Biol Cell. 2010 Jul 01; 21(13):2338-54. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. PMID: 20462955.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    67. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. J Biol Chem. 2010 Apr 23; 285(17):12765-77. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. PMID: 20157114.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    68. Multiple "apple-core" lesions in chronic ischemic colitis: the great masquerader. Am J Gastroenterol. 2009 Nov; 104(11):2870-2. Ghosh P, Carethers JM. PMID: 19888260.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. ArterioVenous Malformation within Jejunal Diverticulum: an unusual cause of massive gastrointestinal bleeding. Gastroenterol Res Pract. 2009; 2009:384506. Lee JK, Carethers JM, Ghosh P. PMID: 19753317.
      View in: PubMed   Mentions:
    70. Generalized megaviscera of lupus: refractory intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus. World J Gastroenterol. 2009 Jul 28; 15(28):3555-9. Park FD, Lee JK, Madduri GD, Ghosh P. PMID: 19630114.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    71. GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3178-83. Garcia-Marcos M, Ghosh P, Farquhar MG. PMID: 19211784.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    72. Activation of Galphai3 triggers cell migration via regulation of GIV. J Cell Biol. 2008 Jul 28; 182(2):381-93. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. PMID: 18663145.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    73. Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma. World J Gastroenterol. 2008 Jul 21; 14(27):4389-94. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S, Carethers JM. PMID: 18666331.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    74. Nonmetastatic cancer of the colon associated with pyogenic liver abscess. Am J Gastroenterol. 2008 Mar; 103(3):798-9. Lee JK, Kum J, Ghosh P. PMID: 18341498.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    75. Sugar rush in the colon: why incidental findings on PET scan justify colonoscopy? Am J Gastroenterol. 2007 Nov; 102(11):2609-10. Ghosh P, Olson RK, Harmon G. PMID: 17958772.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    76. Gastric adenocarcinoma inducing portal hypertension: a rare presentation. World J Gastroenterol. 2007 Feb 14; 13(6):960-3. Ghosh P, Miyai K, Chojkier M. PMID: 17352032.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    77. Mesenteric panniculitis and sclerosing mesenteritis: a continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007 May; 5(5):A32. Ghosh P, Kum J. PMID: 17261382.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    78. Peritoneal mice implicated in intestinal obstruction: report of a case and review of the literature. J Clin Gastroenterol. 2006 May-Jun; 40(5):427-30. Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. PMID: 16721225.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    79. The GGA proteins: key players in protein sorting at the trans-Golgi network. Eur J Cell Biol. 2004 Jul; 83(6):257-62. Ghosh P, Kornfeld S. PMID: 15511083.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    80. The cytoplasmic tail of the cation-independent mannose 6-phosphate receptor contains four binding sites for AP-1. Arch Biochem Biophys. 2004 Jun 15; 426(2):225-30. Ghosh P, Kornfeld S. PMID: 15158672.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    81. Mammalian GGAs act together to sort mannose 6-phosphate receptors. J Cell Biol. 2003 Nov 24; 163(4):755-66. Ghosh P, Griffith J, Geuze HJ, Kornfeld S. PMID: 14638859.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    82. Mannose 6-phosphate receptors: new twists in the tale. Nat Rev Mol Cell Biol. 2003 Mar; 4(3):202-12. Ghosh P, Dahms NM, Kornfeld S. PMID: 12612639.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    83. AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol. 2003 Mar 03; 160(5):699-708. Ghosh P, Kornfeld S. PMID: 12604586.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    84. Phosphorylation-induced conformational changes regulate GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem. 2003 Apr 18; 278(16):14543-9. Ghosh P, Kornfeld S. PMID: 12578827.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    85. Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science. 2002 Sep 06; 297(5587):1700-3. Doray B, Ghosh P, Griffith J, Geuze HJ, Kornfeld S. PMID: 12215646.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    86. Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8072-7. Doray B, Bruns K, Ghosh P, Kornfeld SA. PMID: 12060753.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    87. Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin. J Biol Chem. 2002 Aug 16; 277(33):29737-44. Do H, Lee WS, Ghosh P, Hollowell T, Canfield W, Kornfeld S. PMID: 12058031.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    88. Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins. J Biol Chem. 2002 May 24; 277(21):18477-82. Doray B, Bruns K, Ghosh P, Kornfeld S. PMID: 11886874.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells