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Sean-Paul Nuccio

TitleAssistant Project Scientist
InstitutionUniversity of California San Diego
DepartmentPediatrics
Address9500 Gilman Drive #0704
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    University of California, Davis, Davis, CAPhDMicrobiology
    University of Washington, Seattle, WABSMicrobiology
    Collapse Awards and Honors
    University of California, Davis2009  - 2011NIH AMID Training Grant Fellowship (AI060555)
    University of California, Davis2007  - 2009Floyd and Mary Schwall Fellowship in Medical Research

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Catalan-Dibene J, Vazquez MI, Luu VP, Nuccio SP, Karimzadeh A, Kastenschmidt JM, Villalta SA, Ushach I, Pone EJ, Casali P, Raffatellu M, Burkhardt AM, Hernandez-Ruiz M, Heller G, Hevezi PA, Zlotnik A. Identification of IL-40, a Novel B Cell-Associated Cytokine. J Immunol. 2017 11 01; 199(9):3326-3335. PMID: 28978694.
      View in: PubMed
    2. Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M. Microcins mediate competition among Enterobacteriaceae in the inflamed gut. Nature. 2016 12 08; 540(7632):280-283. PMID: 27798599.
      View in: PubMed
    3. Faber F, Tran L, Byndloss MX, Lopez CA, Velazquez EM, Kerrinnes T, Nuccio SP, Wangdi T, Fiehn O, Tsolis RM, Bäumler AJ. Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature. 2016 06 30; 534(7609):697-9. PMID: 27309805; PMCID: PMC4939260 [Available on 12/30/16].
    4. Diaz-Ochoa VE, Lam D, Lee CS, Klaus S, Behnsen J, Liu JZ, Chim N, Nuccio SP, Rathi SG, Mastroianni JR, Edwards RA, Jacobo CM, Cerasi M, Battistoni A, Ouellette AJ, Goulding CW, Chazin WJ, Skaar EP, Raffatellu M. Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration. Cell Host Microbe. 2016 Jun 08; 19(6):814-25. PMID: 27281571; PMCID: PMC4901528 [Available on 06/08/17].
    5. Perez-Lopez A, Behnsen J, Nuccio SP, Raffatellu M. Mucosal immunity to pathogenic intestinal bacteria. Nat Rev Immunol. 2016 Mar; 16(3):135-48. PMID: 26898110.
      View in: PubMed
    6. Mooney JP, Lee SJ, Lokken KL, Nanton MR, Nuccio SP, McSorley SJ, Tsolis RM. Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria. PLoS Negl Trop Dis. 2015; 9(9):e0004027. PMID: 26366739; PMCID: PMC4569369.
    7. Behnsen J, Perez-Lopez A, Nuccio SP, Raffatellu M. Exploiting host immunity: the Salmonella paradigm. Trends Immunol. 2015 Feb; 36(2):112-20. PMID: 25582038; PMCID: PMC4323876.
    8. Nuccio SP, Bäumler AJ. Reconstructing pathogen evolution from the ruins. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):647-8. PMID: 25568086; PMCID: PMC4311861.
    9. Nanton MR, Lee SJ, Atif SM, Nuccio SP, Taylor JJ, Bäumler AJ, Way SS, McSorley SJ. Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development. Eur J Immunol. 2015 Feb; 45(2):428-41. PMID: 25346524; PMCID: PMC4323875.
    10. Nuccio SP, Bäumler AJ. Comparative analysis of Salmonella genomes identifies a metabolic network for escalating growth in the inflamed gut. MBio. 2014 Mar 18; 5(2):e00929-14. PMID: 24643865; PMCID: PMC3967523.
    11. O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ. Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells. Immunity. 2014 Feb 20; 40(2):213-24. PMID: 24508233; PMCID: PMC3960852.
    12. Sterzenbach T, Nguyen KT, Nuccio SP, Winter MG, Vakulskas CA, Clegg S, Romeo T, Bäumler AJ. A novel CsrA titration mechanism regulates fimbrial gene expression in Salmonella typhimurium. EMBO J. 2013 Oct 30; 32(21):2872-83. PMID: 24056837; PMCID: PMC3817462.
    13. Rivera-Chávez F, Winter SE, Lopez CA, Xavier MN, Winter MG, Nuccio SP, Russell JM, Laughlin RC, Lawhon SD, Sterzenbach T, Bevins CL, Tsolis RM, Harshey R, Adams LG, Bäumler AJ. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog. 2013; 9(4):e1003267. PMID: 23637594; PMCID: PMC3630101.
    14. Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL. Human a-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science. 2012 Jul 27; 337(6093):477-81. PMID: 22722251; PMCID: PMC4332406.
    15. Lopez CA, Winter SE, Rivera-Chávez F, Xavier MN, Poon V, Nuccio SP, Tsolis RM, Bäumler AJ. Phage-mediated acquisition of a type III secreted effector protein boosts growth of salmonella by nitrate respiration. MBio. 2012; 3(3). PMID: 22691391; PMCID: PMC3374392.
    16. Fookes M, Schroeder GN, Langridge GC, Blondel CJ, Mammina C, Connor TR, Seth-Smith H, Vernikos GS, Robinson KS, Sanders M, Petty NK, Kingsley RA, Bäumler AJ, Nuccio SP, Contreras I, Santiviago CA, Maskell D, Barrow P, Humphrey T, Nastasi A, Roberts M, Frankel G, Parkhill J, Dougan G, Thomson NR. Salmonella bongori provides insights into the evolution of the Salmonellae. PLoS Pathog. 2011 Aug; 7(8):e1002191. PMID: 21876672; PMCID: PMC3158058.
    17. Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tükel Ç, Bäumler AJ. The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Infect Immun. 2011 Feb; 79(2):830-7. PMID: 21098104; PMCID: PMC3028862.
    18. Winter SE, Winter MG, Thiennimitr P, Gerriets VA, Nuccio SP, Rüssmann H, Bäumler AJ. The TviA auxiliary protein renders the Salmonella enterica serotype Typhi RcsB regulon responsive to changes in osmolarity. Mol Microbiol. 2009 Oct; 74(1):175-93. PMID: 19703107; PMCID: PMC2763492.
    19. Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, Paixao TA, Butler BP, Chu H, Santos RL, Berger T, Mak TW, Tsolis RM, Bevins CL, Solnick JV, Dandekar S, Bäumler AJ. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe. 2009 May 08; 5(5):476-86. PMID: 19454351; PMCID: PMC2768556.
    20. Winter SE, Thiennimitr P, Nuccio SP, Haneda T, Winter MG, Wilson RP, Russell JM, Henry T, Tran QT, Lawhon SD, Gomez G, Bevins CL, Rüssmann H, Monack DM, Adams LG, Bäumler AJ. Contribution of flagellin pattern recognition to intestinal inflammation during Salmonella enterica serotype typhimurium infection. Infect Immun. 2009 May; 77(5):1904-16. PMID: 19237529; PMCID: PMC2681779.
    21. Chessa D, Winter MG, Nuccio SP, Tükel C, Bäumler AJ. RosE represses Std fimbrial expression in Salmonella enterica serotype Typhimurium. Mol Microbiol. 2008 May; 68(3):573-87. PMID: 18331470; PMCID: PMC2328253.
    22. Nuccio SP, Bäumler AJ. Evolution of the chaperone/usher assembly pathway: fimbrial classification goes Greek. Microbiol Mol Biol Rev. 2007 Dec; 71(4):551-75. PMID: 18063717; PMCID: PMC2168650.
    23. Nuccio SP, Chessa D, Weening EH, Raffatellu M, Clegg S, Bäumler AJ. SIMPLE approach for isolating mutants expressing fimbriae. Appl Environ Microbiol. 2007 Jul; 73(14):4455-62. PMID: 17526787; PMCID: PMC1932825.
    24. Thanassi DG, Nuccio SP, Shu Kin So S, Bäumler AJ. Fimbriae: Classification and Biochemistry. EcoSal Plus. 2007 Apr; 2(2). PMID: 26443587.
      View in: PubMed