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Lars Eckmann

Title(s)Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Postdoctoral1996UC San Diego
    MD1989University of Hamburg, Germany

    Collapse Research 
    Collapse Research Activities and Funding
    San Diego Digestive Diseases Research Center
    NIH/NIDDK P30DK120515Jul 1, 2019 - Apr 30, 2024
    Role: Co-Principal Investigator
    Selective proteasome inhibitors for trichomoniasis
    NIH/NIAID R21AI146387Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    High-potency nitro antimicrobials for topical treatment of trichomoniasis
    NIH/NIAID R41AI118089Feb 4, 2016 - Jan 31, 2017
    Role: Principal Investigator
    Nanoparticle decoys for treating infections with enterotoxin-producing pathogens
    NIH/NIAID R33AI121571Dec 1, 2015 - Nov 30, 2020
    Role: Principal Investigator
    Nanoparticle decoys for treating infections with enterotoxin-producing pathogens
    NIH/NIAID R21AI121571Dec 1, 2015 - Nov 30, 2016
    Role: Principal Investigator
    Next-generation 5-nitro heterocyclic antimicrobials against mucosal protists
    NIH/NIAID R01AI114671Jun 20, 2015 - May 31, 2020
    Role: Principal Investigator
    Protective antigens of Giardia lamblia
    NIH/NIAID R21AI112594Jun 15, 2015 - May 31, 2017
    Role: Principal Investigator
    Gold Compounds for the Topical Treatment of Trichomoniasis
    NIH/NIAID R21AI119459Jun 15, 2015 - May 31, 2017
    Role: Principal Investigator
    Click chemistry for novel antimicrobials against periodontal pathogens
    NIH/NIDCR RC1DE020607Sep 17, 2009 - Aug 31, 2011
    Role: Principal Investigator
    Next-generation 5-nitroimidazoles against giardiasis
    NIH/NIAID U01AI075527Aug 15, 2007 - Jul 31, 2013
    Role: Principal Investigator
    MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    NIH/NIDDK R01DK070867Sep 1, 2006 - Jul 31, 2011
    Role: Principal Investigator
    MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    NIH/NCRR K26RR017030Aug 13, 2004 - Jun 30, 2009
    Role: Principal Investigator
    HOST DEFENSES AGAINST PATHOGENIC E. coli
    NIH/NIAID R01AI056075Sep 30, 2003 - Dec 31, 2008
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis. PLoS Negl Trop Dis. 2020 04; 14(4):e0008224. Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L. PMID: 32302296.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 2019 11; 575(7783):505-511. Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White RC, Clarke TH, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman IR, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Tu XM, Eckmann L, van der Donk WA, Young R, Lawley TD, Stärkel P, Pride D, Fouts DE, Schnabl B. PMID: 31723265.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    3. ß7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. Cell Mol Gastroenterol Hepatol. 2020; 9(3):369-385. Sun H, Kuk W, Rivera-Nieves J, Lopez-Ramirez MA, Eckmann L, Ginsberg MH. PMID: 31707128.
      View in: PubMed   Mentions: 2     Fields:    
    4. Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection. Adv Ther (Weinh). 2019 Dec; 2(12). Zhang Y, Miyamoto Y, Ihara S, Yang JZ, Zuill DE, Angsantikul P, Zhang Q, Gao W, Zhang L, Eckmann L. PMID: 32377561.
      View in: PubMed   Mentions:
    5. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 11; 63(11). O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. PMID: 31451503.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Evaluation of Peroxides and Chlorine Oxides as Disinfectants for Chemical Sterilization of Gnotobiotic Rodent Isolators. J Am Assoc Lab Anim Sci. 2019 09 01; 58(5):558-568. Moody LV, Miyamoto Y, Ang J, Richter PJ, Eckmann L. PMID: 31319899.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    7. Identification of Conserved Candidate Vaccine Antigens in the Surface Proteome of Giardia lamblia. Infect Immun. 2019 06; 87(6). Davids BJ, Liu CM, Hanson EM, Le CHY, Ang J, Hanevik K, Fischer M, Radunovic M, Langeland N, Ferella M, Svärd SG, Ghassemian M, Miyamoto Y, Eckmann L. PMID: 30962402.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 12; 17(13):2634-2643. Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ. PMID: 31009791.
      View in: PubMed   Mentions: 4     Fields:    
    9. Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 10 12; 24(11):2366-2376. Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J. PMID: 29889233.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Complex Network of NKT Cell Subsets Controls Immune Homeostasis in Liver and Gut. Front Immunol. 2018; 9:2082. Marrero I, Maricic I, Feldstein AE, Loomba R, Schnabl B, Rivera-Nieves J, Eckmann L, Kumar V. PMID: 30254647.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Neutralization of cholera toxin with nanoparticle decoys for treatment of cholera. PLoS Negl Trop Dis. 2018 02; 12(2):e0006266. Das S, Angsantikul P, Le C, Bao D, Miyamoto Y, Gao W, Zhang L, Eckmann L. PMID: 29470490.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 12 19; 216(12):1655-1666. Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. PMID: 29029244.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia. Antimicrob Agents Chemother. 2017 06; 61(6). Kim WJ, Korthals KA, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L. PMID: 28396548.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    14. Gut-liver axis at the frontier of host-microbial interactions. Am J Physiol Gastrointest Liver Physiol. 2017 May 01; 312(5):G413-G419. Brandl K, Kumar V, Eckmann L. PMID: 28232456.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    15. Visualizing the enteric nervous system using genetically engineered double reporter mice: Comparison with immunofluorescence. PLoS One. 2017; 12(2):e0171239. Jiang Y, Dong H, Eckmann L, Hanson EM, Ihn KC, Mittal RK. PMID: 28158225.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes. J Allergy Clin Immunol. 2017 Apr; 139(4):1205-1216.e6. Wang Z, Mascarenhas N, Eckmann L, Miyamoto Y, Sun X, Kawakami T, Di Nardo A. PMID: 27746235.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. TLR3 signaling is downregulated by a MAVS isoform in epithelial cells. Cell Immunol. 2016 12; 310:205-210. Lakhdari O, McAllister CS, Wang M, Minev I, Prince LS, Eckmann L, Kagnoff MF. PMID: 27593154.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Microbiota and Alcoholic Liver Disease. Alcohol Clin Exp Res. 2016 08; 40(8):1791-2. Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B. PMID: 27364225.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog. 2016 Jan; 12(1):e1005382. den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE. PMID: 26761793.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    20. Drug Development Against the Major Diarrhea-Causing Parasites of the Small Intestine, Cryptosporidium and Giardia. Front Microbiol. 2015; 6:1208. Miyamoto Y, Eckmann L. PMID: 26635732.
      View in: PubMed   Mentions:
    21. Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury. Alcohol Clin Exp Res. 2015 Dec; 39(12):2313-23. Chen P, Miyamoto Y, Mazagova M, Lee KC, Eckmann L, Schnabl B. PMID: 26556636.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    22. Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules. J Leukoc Biol. 2016 Mar; 99(3):475-82. Solaymani-Mohammadi S, Lakhdari O, Minev I, Shenouda S, Frey BF, Billeskov R, Singer SM, Berzofsky JA, Eckmann L, Kagnoff MF. PMID: 26467188.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. IgG "detoxes" the intestinal mucosa. . 2015 May 13; 17(5):538-9. Eckmann L, Stappenbeck TS. PMID: 25974292.
      View in: PubMed   Mentions:
    24. ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cell Mol Gastroenterol Hepatol. 2015 Apr 01; 1(3):311-324. Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB. PMID: 26878033.
      View in: PubMed   Mentions: 5     Fields:    
    25. Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis. 2015 Feb; 21(2):323-30. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT. PMID: 25545378.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Martin F. Kagnoff, MD, January 19, 1941--November 16, 2014. Gastroenterology. 2015 Mar; 148(3):457-8. Eckmann L, Barrett KE, Carethers JM. PMID: 25620667.
      View in: PubMed   Mentions:    Fields:    
    27. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. FASEB J. 2015 Mar; 29(3):1043-55. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B. PMID: 25466902.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    28. Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis. Aliment Pharmacol Ther. 2014 Sep; 40(5):477-85. Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT. PMID: 25041724.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. . 2014 Jul 15; 307(2):C180-9. Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang JY, Eckmann L. PMID: 24848114.
      View in: PubMed   Mentions:
    30. Phosphorylation of eIF2a is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflamm Bowel Dis. 2014 Apr; 20(4):712-22. Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. PMID: 24577114.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    31. Human milk oligosaccharides protect against enteropathogenic Escherichia coli attachment in vitro and EPEC colonization in suckling mice. J Pediatr Gastroenterol Nutr. 2014 Feb; 58(2):165-8. Manthey CF, Autran CA, Eckmann L, Bode L. PMID: 24048169.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17564-9. Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. PMID: 24101497.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    33. Trp53 deficiency protects against acute intestinal inflammation. J Immunol. 2013 Jul 15; 191(2):837-47. Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L. PMID: 23772033.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. PMID: 23403423.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    35. Nuclear expression of ß-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013 Mar; 11(3):207-18. Han J, Soletti RC, Sadarangani A, Sridevi P, Ramirez ME, Eckmann L, Borges HL, Wang JY. PMID: 23339186.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. J Immunol. 2013 Jan 01; 190(1):418-27. McAllister CS, Lakhdari O, Pineton de Chambrun G, Gareau MG, Broquet A, Lee GH, Shenouda S, Eckmann L, Kagnoff MF. PMID: 23209324.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    37. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. PMID: 23034650.
      View in: PubMed   Mentions: 370     Fields:    Translation:HumansAnimalsCells
    38. Ulcerative colitis. Lancet. 2012 Nov 03; 380(9853):1606-19. Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. PMID: 22914296.
      View in: PubMed   Mentions: 291     Fields:    Translation:Humans
    39. Divergent requirement for Gas and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets. J Clin Invest. 2012 Mar; 122(3):963-73. Li X, Murray F, Koide N, Goldstone J, Dann SM, Chen J, Bertin S, Fu G, Weinstein LS, Chen M, Corr M, Eckmann L, Insel PA, Raz E. PMID: 22326954.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    40. Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing. Infect Immun. 2012 Jan; 80(1):143-9. Cobo ER, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo RL, Reed SL. PMID: 22083705.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    41. ?1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model. Vaccine. 2011 Nov 28; 29(51):9529-37. Jenikova G, Hruz P, Andersson MK, Tejman-Yarden N, Ferreira PC, Andersen YS, Davids BJ, Gillin FD, Svärd SG, Curtiss R, Eckmann L. PMID: 22001876.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    42. New approaches to the treatment of giardiasis. Curr Opin Infect Dis. 2011 Oct; 24(5):451-6. Tejman-Yarden N, Eckmann L. PMID: 21857510.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    43. Murine models of vaginal trichomonad infections. Am J Trop Med Hyg. 2011 Oct; 85(4):667-73. Cobo ER, Eckmann L, Corbeil LB. PMID: 21976570.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    44. Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia. Antimicrob Agents Chemother. 2011 Oct; 55(10):4643-51. Tejman-Yarden N, Millman M, Lauwaet T, Davids BJ, Gillin FD, Dunn L, Upcroft JA, Miyamoto Y, Eckmann L. PMID: 21825286.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    45. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. PMID: 21825016.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    46. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44. Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. PMID: 21683629.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    47. NF-?B and mucosal homeostasis. Curr Top Microbiol Immunol. 2011; 349:145-58. Eckmann L, Neish AS. PMID: 20838961.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med. 2010 Dec 20; 207(13):2799-807. González-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. PMID: 21115691.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    49. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11; 285(24):18516-27. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. PMID: 20378535.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    50. STAT3 and its activators in intestinal defense and mucosal homeostasis. Curr Opin Gastroenterol. 2010 Mar; 26(2):109-15. Hruz P, Dann SM, Eckmann L. PMID: 20040863.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    51. GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen. . 2010 Feb 18; 7(2):151-63. Hirata Y, Egea L, Dann SM, Eckmann L, Kagnoff MF. PMID: 20159620.
      View in: PubMed   Mentions:
    52. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem. 2010 Apr 23; 285(17):12504-11. Choi LJ, Jenikova G, Hanson E, Spehlmann ME, Boehling NS, Kirstein SL, Bundey RA, Smith JR, Insel PA, Eckmann L. PMID: 20157112.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    53. Rapid detachment of Giardia lamblia trophozoites as a mechanism of antimicrobial action of the isoflavone formononetin. J Antimicrob Chemother. 2010 Mar; 65(3):531-4. Lauwaet T, Andersen Y, Van de Ven L, Eckmann L, Gillin FD. PMID: 20067984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    54. CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol. 2009 Sep 01; 183(5):3332-43. Spehlmann ME, Dann SM, Hruz P, Hanson E, McCole DF, Eckmann L. PMID: 19675161.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    55. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    56. Nuclear factor-kappa B in intestinal protection and destruction. Curr Opin Gastroenterol. 2009 Mar; 25(2):92-9. Spehlmann ME, Eckmann L. PMID: 19528876.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsPHPublic Health
    57. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. PMID: 19185845.
      View in: PubMed   Mentions: 730     Fields:    Translation:HumansAnimalsCells
    58. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63. Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. PMID: 18815378.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    59. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. PMID: 18511561.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    60. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 2008 May 15; 180(10):6816-26. Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L. PMID: 18453602.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    61. Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity. Curr Opin Gastroenterol. 2008 Mar; 24(2):108-14. Hruz P, Eckmann L. PMID: 18301258.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    62. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17022-7. Abe K, Nguyen KP, Fine SD, Mo JH, Shen C, Shenouda S, Corr M, Jung S, Lee J, Eckmann L, Raz E. PMID: 17942668.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    63. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. PMID: 17513563.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    64. Innate immune defenses in the intestinal tract. Curr Opin Gastroenterol. 2007 Mar; 23(2):115-20. Dann SM, Eckmann L. PMID: 17268238.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    65. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006 Dec; 8(12):1327-36. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E. PMID: 17128265.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimalsCells
    66. Polymeric immunoglobulin receptor in intestinal immune defense against the lumen-dwelling protozoan parasite Giardia. J Immunol. 2006 Nov 01; 177(9):6281-90. Davids BJ, Palm JE, Housley MP, Smith JR, Andersen YS, Martin MG, Hendrickson BA, Johansen FE, Svärd SG, Gillin FD, Eckmann L. PMID: 17056558.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    67. Animal models of inflammatory bowel disease: lessons from enteric infections. Ann N Y Acad Sci. 2006 Aug; 1072:28-38. Eckmann L. PMID: 17057188.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    68. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20. Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. PMID: 16818780.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    69. Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp. Infect Immun. 2006 Apr; 74(4):2473-6. Andersen YS, Gillin FD, Eckmann L. PMID: 16552082.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    70. How bile acids confer gut mucosal protection against bacteria. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4333-4. Hofmann AF, Eckmann L. PMID: 16537368.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    71. Sensor molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol. 2006 Mar; 22(2):95-101. Eckmann L. PMID: 16462163.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    72. Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15587-92. Borges HL, Bird J, Wasson K, Cardiff RD, Varki N, Eckmann L, Wang JY. PMID: 16227443.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    73. Intestinal mucosal responses to microbial infection. Springer Semin Immunopathol. 2005 Sep; 27(2):181-96. Eckmann L, Kagnoff MF. PMID: 15928914.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    74. NOD2 and Crohn's disease: loss or gain of function? Immunity. 2005 Jun; 22(6):661-7. Eckmann L, Karin M. PMID: 15963781.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    75. Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J Immunol. 2005 Apr 15; 174(8):4901-7. Iimura M, Gallo RL, Hase K, Miyamoto Y, Eckmann L, Kagnoff MF. PMID: 15814717.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    76. Defence molecules in intestinal innate immunity against bacterial infections. Curr Opin Gastroenterol. 2005 Mar; 21(2):147-51. Eckmann L. PMID: 15711205.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    77. Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest. 2005 Mar; 115(3):695-702. Katakura K, Lee J, Rachmilewitz D, Li G, Eckmann L, Raz E. PMID: 15765149.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    78. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. PMID: 15692052.
      View in: PubMed   Mentions: 237     Fields:    Translation:AnimalsCells
    79. Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. . 2005 Feb; 288(2):C321-8. Yang CC, Ogawa H, Dwinell MB, McCole DF, Eckmann L, Kagnoff MF. PMID: 15483227.
      View in: PubMed   Mentions:
    80. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. PMID: 15294155.
      View in: PubMed   Mentions: 853     Fields:    Translation:AnimalsCells
    81. Regulated production of the chemokine CCL28 in human colon epithelium. Am J Physiol Gastrointest Liver Physiol. 2004 Nov; 287(5):G1062-9. Ogawa H, Iimura M, Eckmann L, Kagnoff MF. PMID: 15246961.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    82. Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium. Immunology. 2004 Jul; 112(3):437-45. Maaser C, Egan LJ, Birkenbach MP, Eckmann L, Kagnoff MF. PMID: 15196212.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    83. Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD. . 2004 Oct; 287(4):C939-48. Bertelsen LS, Paesold G, Marcus SL, Finlay BB, Eckmann L, Barrett KE. PMID: 15175224.
      View in: PubMed   Mentions:
    84. Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies. Infect Immun. 2004 Jun; 72(6):3315-24. Maaser C, Housley MP, Iimura M, Smith JR, Vallance BA, Finlay BB, Schreiber JR, Varki NM, Kagnoff MF, Eckmann L. PMID: 15155635.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    85. Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. J Biol Chem. 2004 Jun 18; 279(25):26176-83. Nishihara H, Hwang M, Kizaka-Kondoh S, Eckmann L, Insel PA. PMID: 15078890.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    86. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. PMID: 15029200.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    87. Innate immunity and mucosal bacterial interactions in the intestine. Curr Opin Gastroenterol. 2004 Mar; 20(2):82-8. Eckmann L. PMID: 15703626.
      View in: PubMed   Mentions: 11     Fields:    
    88. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. PMID: 14983030.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    89. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology. 2003 Dec; 125(6):1613-25. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, Kagnoff MF. PMID: 14724813.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    90. Prolonged interferon-gamma exposure decreases ion transport, NKCC1, and Na+-K+-ATPase expression in human intestinal xenografts in vivo. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G157-65. Bertelsen LS, Eckmann L, Barrett KE. PMID: 12958023.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    91. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8921-6. Nishihara H, Kizaka-Kondoh S, Insel PA, Eckmann L. PMID: 12837940.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    92. Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers. . 2003 Nov; 285(5):C1028-35. Egan LJ, de Lecea A, Lehrman ED, Myhre GM, Eckmann L, Kagnoff MF. PMID: 12826601.
      View in: PubMed   Mentions:
    93. Mucosal defences against Giardia. Parasite Immunol. 2003 May; 25(5):259-70. Eckmann L. PMID: 12969444.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    94. Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. Infect Immun. 2003 Apr; 71(4):2102-9. Bertelsen LS, Paesold G, Eckmann L, Barrett KE. PMID: 12654832.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    95. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. PMID: 12595442.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    96. Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells. Cell Microbiol. 2002 Nov; 4(11):771-81. Paesold G, Guiney DG, Eckmann L, Kagnoff MF. PMID: 12427099.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    97. Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium. Gastroenterology. 2002 Mar; 122(3):667-80. Maaser C, Eckmann L, Paesold G, Kim HS, Kagnoff MF. PMID: 11875000.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    98. Small bowel infections. Curr Opin Gastroenterol. 2002 Mar; 18(2):197-202. Eckmann L. PMID: 17033287.
      View in: PubMed   Mentions: 2     Fields:    
    99. Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun. 2002 Feb; 70(2):953-63. Hase K, Eckmann L, Leopard JD, Varki N, Kagnoff MF. PMID: 11796631.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    100. Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis. 2002 Jan 15; 185(2):196-203. Doran KS, Chang JC, Benoit VM, Eckmann L, Nizet V. PMID: 11807693.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    101. Central importance of immunoglobulin A in host defense against Giardia spp. Infect Immun. 2002 Jan; 70(1):11-8. Langford TD, Housley MP, Boes M, Chen J, Kagnoff MF, Gillin FD, Eckmann L. PMID: 11748158.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    102. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. . 2001 Dec; 281(6):C1837-49. Resta-Lenert S, Truong F, Barrett KE, Eckmann L. PMID: 11698242.
      View in: PubMed   Mentions:
    103. Cytokines in host defense against Salmonella. Microbes Infect. 2001 Nov-Dec; 3(14-15):1191-200. Eckmann L, Kagnoff MF. PMID: 11755407.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    104. Analysis of host responses to microbial infection using gene expression profiling. Curr Opin Microbiol. 2001 Jun; 4(3):246-50. Kagnoff MF, Eckmann L. PMID: 11378474.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    105. Production of MDC/CCL22 by human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1217-26. Berin MC, Dwinell MB, Eckmann L, Kagnoff MF. PMID: 11352815.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    106. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol. 2001 Apr; 24(4):382-9. Berin MC, Eckmann L, Broide DH, Kagnoff MF. PMID: 11306430.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    107. Regulated MIP-3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol. 2001 Apr; 280(4):G710-9. Izadpanah A, Dwinell MB, Eckmann L, Varki NM, Kagnoff MF. PMID: 11254498.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    108. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology. 2001 Jan; 120(1):49-59. Dwinell MB, Lügering N, Eckmann L, Kagnoff MF. PMID: 11208713.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    109. Microbes and microbial toxins: paradigms for microbial-mucosal interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogen Giardia lamblia. Am J Physiol Gastrointest Liver Physiol. 2001 Jan; 280(1):G1-6. Eckmann L, Gillin FD. PMID: 11123191.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    110. Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella. J Biol Chem. 2000 May 12; 275(19):14084-94. Eckmann L, Smith JR, Housley MP, Dwinell MB, Kagnoff MF. PMID: 10799483.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    111. Intestinal epithelial cell apoptosis following Cryptosporidium parvum infection. Infect Immun. 2000 Mar; 68(3):1710-3. McCole DF, Eckmann L, Laurent F, Kagnoff MF. PMID: 10678994.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    112. Nitric oxide production by human intestinal epithelial cells and competition for arginine as potential determinants of host defense against the lumen-dwelling pathogen Giardia lamblia. J Immunol. 2000 Feb 01; 164(3):1478-87. Eckmann L, Laurent F, Langford TD, Hetsko ML, Smith JR, Kagnoff MF, Gillin FD. PMID: 10640765.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    113. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol. 1999 Dec 15; 163(12):6718-24. O'Neil DA, Porter EM, Elewaut D, Anderson GM, Eckmann L, Ganz T, Kagnoff MF. PMID: 10586069.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansCells
    114. Human intestinal epithelial cells express receptors for platelet-activating factor. Am J Physiol. 1999 10; 277(4):G810-8. Merendino N, Dwinell MB, Varki N, Eckmann L, Kagnoff MF. PMID: 10516147.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    115. Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology. 1999 Aug; 117(2):359-67. Dwinell MB, Eckmann L, Leopard JD, Varki NM, Kagnoff MF. PMID: 10419917.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    116. NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. J Immunol. 1999 Aug 01; 163(3):1457-66. Elewaut D, DiDonato JA, Kim JM, Truong F, Eckmann L, Kagnoff MF. PMID: 10415047.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    117. Chemokine secretion of human cells in response to Toxoplasma gondii infection. Infect Immun. 1999 Apr; 67(4):1547-52. Denney CF, Eckmann L, Reed SL. PMID: 10084985.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    118. Pathogenesis of Cryptosporidium parvum infection. Microbes Infect. 1999 Feb; 1(2):141-8. Laurent F, McCole D, Eckmann L, Kagnoff MF. PMID: 10594978.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    119. Apoptosis of human intestinal epithelial cells after bacterial invasion. J Clin Invest. 1998 Nov 15; 102(10):1815-23. Kim JM, Eckmann L, Savidge TC, Lowe DC, Witthöft T, Kagnoff MF. PMID: 9819367.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    120. Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells. Am J Physiol. 1998 09; 275(3):G564-71. Witthöft T, Eckmann L, Kim JM, Kagnoff MF. PMID: 9724270.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    121. Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis. Infect Immun. 1998 Sep; 66(9):4397-402. Fierer J, Walls L, Eckmann L, Yamamoto T, Kirkland TN. PMID: 9712793.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    122. Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production. Infect Immun. 1998 Apr; 66(4):1787-90. Laurent F, Kagnoff MF, Savidge TC, Naciri M, Eckmann L. PMID: 9529115.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    123. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14456-60. Eckmann L, Rudolf MT, Ptasznik A, Schultz C, Jiang T, Wolfson N, Tsien R, Fierer J, Shears SB, Kagnoff MF, Traynor-Kaplan AE. PMID: 9405634.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    124. Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect Immun. 1997 Dec; 65(12):5067-73. Laurent F, Eckmann L, Savidge TC, Morgan G, Theodos C, Naciri M, Kagnoff MF. PMID: 9393797.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    125. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology. 1997 Oct; 113(4):1214-23. Yang SK, Eckmann L, Panja A, Kagnoff MF. PMID: 9322516.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    126. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion. Am J Physiol. 1997 Aug; 273(2 Pt 1):G322-32. Rowell DL, Eckmann L, Dwinell MB, Carpenter SP, Raucy JL, Yang SK, Kagnoff MF. PMID: 9277410.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    127. Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. J Clin Invest. 1997 Jul 15; 100(2):296-309. Eckmann L, Stenson WF, Savidge TC, Lowe DC, Barrett KE, Fierer J, Smith JR, Kagnoff MF. PMID: 9218506.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    128. Epithelial cells as sensors for microbial infection. J Clin Invest. 1997 Jul 01; 100(1):6-10. Kagnoff MF, Eckmann L. PMID: 9202050.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimals
    129. Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes. Infect Immun. 1997 Jun; 65(6):2306-12. Weintraub BC, Eckmann L, Okamoto S, Hense M, Hedrick SM, Fierer J. PMID: 9169768.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    130. Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion. Infect Immun. 1997 Feb; 65(2):843-6. Cole SP, Cirillo D, Kagnoff MF, Guiney DG, Eckmann L. PMID: 9009355.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    131. Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells. Infect Immun. 1996 Nov; 64(11):4739-43. Chen CY, Eckmann L, Libby SJ, Fang FC, Okamoto S, Kagnoff MF, Fierer J, Guiney DG. PMID: 8890234.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    132. Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J Clin Invest. 1996 Jul 15; 98(2):572-83. Huang GT, Eckmann L, Savidge TC, Kagnoff MF. PMID: 8755670.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    133. Genetically resistant (Ityr) and susceptible (Itys) congenic mouse strains show similar cytokine responses following infection with Salmonella dublin. J Immunol. 1996 Apr 15; 156(8):2894-900. Eckmann L, Fierer J, Kagnoff MF. PMID: 8609409.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    134. Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha. J Clin Invest. 1995 Sep; 96(3):1269-79. Eckmann L, Reed SL, Smith JR, Kagnoff MF. PMID: 7657801.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    135. Intestinal epithelial cells as watchdogs for the natural immune system. Trends Microbiol. 1995 Mar; 3(3):118-20. Eckmann L, Kagnoff MF, Fierer J. PMID: 7773590.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    136. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest. 1995 Jan; 95(1):55-65. Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF. PMID: 7814646.
      View in: PubMed   Mentions: 351     Fields:    Translation:HumansAnimalsCells
    137. Increased transcription and coordinate stabilization of mRNAs for secreted immunoglobulin alpha heavy chain and kappa light chain following stimulation of immunoglobulin A expressing B cells. J Biol Chem. 1994 Dec 30; 269(52):33102-8. Eckmann L, Huang GT, Smith JR, Morzycka-Wroblewska E, Kagnoff MF. PMID: 7806538.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    138. Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide. Immunology. 1994 Jan; 81(1):85-91. Schuerer-Maly CC, Eckmann L, Kagnoff MF, Falco MT, Maly FE. PMID: 8132225.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    139. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology. 1993 Dec; 105(6):1689-97. Eckmann L, Jung HC, Schürer-Maly C, Panja A, Morzycka-Wroblewska E, Kagnoff MF. PMID: 8253345.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansCells
    140. Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells. Infect Immun. 1993 Dec; 61(12):5231-6. Fierer J, Eckmann L, Fang F, Pfeifer C, Finlay BB, Guiney D. PMID: 8225598.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    141. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immun. 1993 Nov; 61(11):4569-74. Eckmann L, Kagnoff MF, Fierer J. PMID: 8406853.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    142. IL-8 secreted by epithelial cells invaded by bacteria. Infect Agents Dis. 1993 Aug; 2(4):255-8. Fierer J, Eckmann L, Kagnoff M. PMID: 8173804.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    143. Cytokine-induced differentiation of IgA B cells: studies using an IgA expressing B-cell lymphoma. Immunology. 1992 Jun; 76(2):235-41. Eckmann L, Morzycka-Wroblewska E, Smith JR, Kagnoff MF. PMID: 1634247.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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