Loading...

Jack Dixon

TitleProfessor
InstitutionUniversity of California San Diego
DepartmentCellular and Molecular Medicine
Address9500 Gilman Drive #0721
La Jolla CA 92093
Phone858-822-0491
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Lafora epilepsy mechanisms: insights into brain metabolism
    NIH/NINDS R13NS096928May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    YopT: A Yersinia Virulence Factor
    NIH/NIAID R21AI064614Apr 15, 2005 - Mar 31, 2007
    Role: Principal Investigator
    Fic-mediated Adenylylation
    NIH/NIGMS R01GM090328May 15, 2004 - Jul 31, 2014
    Role: Principal Investigator
    Molecular Mechanism of Pathogenesis
    NIH/NIAID R01AI060662May 15, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Conference: Second Messengers &Protein Phosphorylation
    NIH/NIDDK R13DK060093Jun 1, 2001 - May 31, 2002
    Role: Principal Investigator
    FASEB SUMMER CONFERENCE--RECEPTORS/SIGNAL TRANSDUCTION
    NIH/NIDDK R13DK058154Jul 17, 2000 - Jun 30, 2001
    Role: Principal Investigator
    MODEL 370A-01 AUTOMATED DNA SEQUENCER SYSTEM
    NIH/NCRR S10RR004849Jul 20, 1989 - Jan 19, 1991
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    EUCARYOTIC METABOLIC REGULATION
    NIH/NIDDK T32DK007532Dec 1, 1986 - Nov 30, 1997
    Role: Principal Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    Gastointestinal Hormone Research Core Center
    NIH P30DK034933Sep 30, 1984 - Nov 30, 2016
    Role: Co-Investigator
    ENDOCRINOLOGY STUDY SECTION
    NIH/CSR U09RG011666Jul 1, 1984 - Jun 30, 1991
    Role: Principal Investigator
    Novel Secreted Kinases
    NIH/NIDDK R01DK018024Jun 1, 1979 - Jul 31, 2019
    Role: Principal Investigator
    Phosphoinositide Phosphatases
    NIH/NIDDK R37DK018024Jun 1, 1979 - Jul 31, 2014
    Role: Principal Investigator
    STUDIES ON PANCREATIC HORMONES
    NIH/NIADDK R01AM018024Jun 1, 1979 - May 31, 1988
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000042Dec 1, 1977 - Feb 28, 2011
    Role: Co-Investigator
    Michigan Diabetes Research and Training Center
    NIH P60DK020572Sep 1, 1977 - Feb 9, 2013
    Role: Co-Investigator
    Regulation and Function of the Secretory Phosphoproteome
    NIH/NIDDK R01DK018849May 1, 1976 - Jun 30, 2021
    Role: Principal Investigator
    REGULATION OF NEUROPEPTIDE BIOSYNTHESIS
    NIH/NIADDK R01AM018849May 1, 1976 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Banerjee S, Ji C, Mayfield JE, Goel A, Xiao J, Dixon J, Guo X. Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc Natl Acad Sci U S A. 2018 Jul 09. PMID: 29987021.
      View in: PubMed
    2. Zhang H, Zhu Q, Cui J, Wang Y, Chen MJ, Guo X, Tagliabracci VS, Dixon J, Xiao J. Structure and evolution of the Fam20 kinases. Nat Commun. 2018 Mar 23; 9(1):1218. PMID: 29572475.
      View in: PubMed
    3. Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon J, Kranias EG. Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proc Natl Acad Sci U S A. 2017 Aug 22; 114(34):9098-9103. PMID: 28784772.
      View in: PubMed
    4. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon J, Xiao J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6. PMID: 28432788.
      View in: PubMed
    5. Chen MJ, Dixon J, Manning G. Genomics and evolution of protein phosphatases. Sci Signal. 2017 Apr 11; 10(474). PMID: 28400531.
      View in: PubMed
    6. Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon J, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L. Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol Cell Proteomics. 2017 May; 16(5):840-854. PMID: 28292943.
      View in: PubMed
    7. Zhu Q, Venzke D, Walimbe AS, Anderson ME, Fu Q, Kinch LN, Wang W, Chen X, Grishin NV, Huang N, Yu L, Dixon J, Campbell KP, Xiao J. Structure of protein O-mannose kinase reveals a unique active site architecture. Elife. 2016 11 23; 5. PMID: 27879205.
      View in: PubMed
    8. Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon J, Tagliabracci VS. Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3482-91. PMID: 27185916; PMCID: PMC4922149 [Available on 12/21/16].
    9. Guo X, Dixon J. The 26S proteasome: A cell cycle regulator regulated by cell cycle. Cell Cycle. 2016; 15(7):875-6. PMID: 26940127; PMCID: PMC4889267 [Available on 03/03/17].
    10. Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon J. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016 Feb; 18(2):202-12. PMID: 26655835; PMCID: PMC4844191.
    11. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon J. A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18; 161(7):1619-32. PMID: 26091039; PMCID: PMC4963185.
    12. Cozza G, Salvi M, Banerjee S, Tibaldi E, Tagliabracci VS, Dixon J, Pinna LA. A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1718-26. PMID: 25936777.
      View in: PubMed
    13. He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon J, Zhang ZY. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorg Med Chem. 2015 Jun 15; 23(12):2798-809. PMID: 25907364; PMCID: PMC4451428.
    14. Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon J. A secretory kinase complex regulates extracellular protein phosphorylation. Elife. 2015 Mar 19; 4:e06120. PMID: 25789606; PMCID: PMC4421793.
    15. Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko JD, Dixon J. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15723-8. PMID: 25331875; PMCID: PMC4226115.
    16. Worby CA, Dixon J. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-1224. PMID: 25215479.
      View in: PubMed
    17. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon J, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
    18. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon J. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5520-5. PMID: 24706917; PMCID: PMC3992636.
    19. Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon J, Dorrestein PC, Nizet V. Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics. 2014 May; 13(5):1262-72. PMID: 24567418; PMCID: PMC4014283.
    20. Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon J, Mirny LA, Mukherjee S, Reizis B. ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia. Cell Rep. 2014 Feb 13; 6(3):528-40. PMID: 24485662; PMCID: PMC3936793.
    21. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon J, Oegema K. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. PMID: 24449268; PMCID: PMC3909786.
    22. Worby CA, Dixon J. PTEN. Annu Rev Biochem. 2014; 83:641-69. PMID: 24905788.
      View in: PubMed
    23. Qi D, Dubiella U, Kim SH, Sloss DI, Dowen RH, Dixon J, Innes RW. Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Plant Physiol. 2014 Jan; 164(1):340-51. PMID: 24225654; PMCID: PMC3875812.
    24. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon J, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 04; 79(5):903-16. PMID: 24012004; PMCID: PMC3779136.
    25. Tagliabracci VS, Pinna LA, Dixon J. Response to Wang et al.: Secreted protein kinases? Trends Biochem Sci. 2013 Sep; 38(9):425. PMID: 23992948.
      View in: PubMed
    26. Tagliabracci VS, Xiao J, Dixon J. Phosphorylation of substrates destined for secretion by the Fam20 kinases. Biochem Soc Trans. 2013 Aug; 41(4):1061-5. PMID: 23863179.
      View in: PubMed
    27. Xiao J, Tagliabracci VS, Wen J, Kim SA, Dixon J. Crystal structure of the Golgi casein kinase. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10574-9. PMID: 23754375; PMCID: PMC3696822.
    28. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon J, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906; PMCID: PMC3779451.
    29. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon J, Zhang J. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013 Feb 15; 288(7):5176-85. PMID: 23293031; PMCID: PMC3576122.
    30. Tagliabracci VS, Pinna LA, Dixon J. Secreted protein kinases. Trends Biochem Sci. 2013 Mar; 38(3):121-30. PMID: 23276407; PMCID: PMC3582740.
    31. Dowen RH, Pelizzola M, Schmitz RJ, Lister R, Dowen JM, Nery JR, Dixon J, Ecker JR. Widespread dynamic DNA methylation in response to biotic stress. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2183-91. PMID: 22733782; PMCID: PMC3420206.
    32. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon J. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 01; 336(6085):1150-3. PMID: 22582013; PMCID: PMC3754843.
    33. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon J, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20; 287(17):13889-98. PMID: 22371493; PMCID: PMC3340166.
    34. Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon J, Goodman JM. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012 Jan 27; 287(5):3123-37. PMID: 22134922; PMCID: PMC3283218.
    35. Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon J. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18649-54. PMID: 21949367; PMCID: PMC3219150.
    36. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon J, Worby CA. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. PMID: 21795713; PMCID: PMC3173180.
    37. Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon J. Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11860-5. PMID: 21730175; PMCID: PMC3142007.
    38. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon J. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
    39. Pei J, Mitchell DA, Dixon J, Grishin NV. Expansion of type II CAAX proteases reveals evolutionary origin of ?-secretase subunit APH-1. J Mol Biol. 2011 Jul 01; 410(1):18-26. PMID: 21570408; PMCID: PMC3155266.
    40. Worby CA, Dixon J. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 02; 13(3):233-4. PMID: 21356510.
      View in: PubMed
    41. Okamura Y, Dixon J. Voltage-sensing phosphatase: its molecular relationship with PTEN. Physiology (Bethesda). 2011 Feb; 26(1):6-13. PMID: 21357898.
      View in: PubMed
    42. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon J. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. PMID: 20622875; PMCID: PMC2920259.
    43. Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon J, Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 03; 285(36):28220-8. PMID: 20581111; PMCID: PMC2934687.
    44. Zhang M, Liu J, Kim Y, Dixon J, Pfaff SL, Gill GN, Noel JP, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86. PMID: 20222012; PMCID: PMC2868240.
    45. Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon J, Casey PJ. Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther. 2010 May; 333(2):584-92. PMID: 20167843; PMCID: PMC2872949.
    46. Gentry MS, Dixon J, Worby CA. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. PMID: 19818631.
      View in: PubMed
    47. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon J. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. PMID: 19362538; PMCID: PMC2820730.
    48. Dowen RH, Engel JL, Shao F, Ecker JR, Dixon J. A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes. J Biol Chem. 2009 Jun 05; 284(23):15867-79. PMID: 19346252; PMCID: PMC2708883.
    49. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon J. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. PMID: 19341700; PMCID: PMC2713743.
    50. Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon J. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem. 2009 May 08; 284(19):13004-12. PMID: 19286651; PMCID: PMC2676033.
    51. Wiley SE, Rardin MJ, Dixon J. Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET. Methods Enzymol. 2009; 456:233-46. PMID: 19348892.
      View in: PubMed
    52. Rardin MJ, Taylor GS, Dixon J. Distinguishing mitochondrial inner membrane orientation of dual specific phosphatase 18 and 21. Methods Enzymol. 2009; 457:275-87. PMID: 19426873.
      View in: PubMed
    53. Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon J, Chai J, Miller SI. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe. 2008 Nov 13; 4(5):434-46. PMID: 18996344; PMCID: PMC2658612.
    54. Geertsema RS, Worby C, Kruger RP, Tagawa Y, Russo R, Herdman DS, Lo K, Kimball RA, Dixon J, Corbeil LB. Protection of mice against H. somni septicemia by vaccination with recombinant immunoglobulin binding protein subunits. Vaccine. 2008 Aug 18; 26(35):4506-12. PMID: 18590787; PMCID: PMC2659705.
    55. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon J, McCormack T, Sasaki T, Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. PMID: 18524949; PMCID: PMC2430346.
    56. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008 May 30; 283(22):15440-50. PMID: 18385140; PMCID: PMC2397459.
    57. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon J. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. PMID: 18375757; PMCID: PMC2311365.
    58. Robinson FL, Niesman IR, Beiswenger KK, Dixon J. Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4916-21. PMID: 18349142; PMCID: PMC2290800.
    59. Mattoo S, Alto NM, Dixon J. Subversion of myosin function by E. coli. Dev Cell. 2008 Jan; 14(1):8-10. PMID: 18194648.
      View in: PubMed
    60. Alto NM, Dixon J. Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins. Methods Enzymol. 2008; 439:131-43. PMID: 18374161.
      View in: PubMed
    61. Worby CA, Gentry MS, Dixon J. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. PMID: 18070875; PMCID: PMC2251628.
    62. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon J, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
    63. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon J. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247; PMCID: PMC2064658.
    64. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon J, Jennings PA. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14342-7. PMID: 17766440; PMCID: PMC1963346.
    65. Mattoo S, Lee YM, Dixon J. Interactions of bacterial effector proteins with host proteins. Curr Opin Immunol. 2007 Aug; 19(4):392-401. PMID: 17662586.
      View in: PubMed
    66. Gentry MS, Dowen RH, Worby CA, Mattoo S, Ecker JR, Dixon J. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. PMID: 17646401; PMCID: PMC2064834.
    67. Cech T, Dixon J, Meehan A, Briggs J, Rhodes C. A reply from Howard Hughes Medical Institute (HHMI). J Cell Biol. 2007 Jul 30; 178(3):343; discussion 343. PMID: 17646394; PMCID: PMC2064853.
    68. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon J. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. PMID: 17584744.
      View in: PubMed
    69. Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon J. Identification of a molecular target for the Yersinia protein kinase A. Mol Cell. 2007 May 25; 26(4):465-77. PMID: 17531806.
      View in: PubMed
    70. Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC, Dixon J. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6596-601. PMID: 17420445; PMCID: PMC1871831.
    71. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon J. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5318-23. PMID: 17376863; PMCID: PMC1838440.
    72. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon J, Taylor SS, Strausberg RL, Frazier M, Venter JC. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. PMID: 17355171; PMCID: PMC1821046.
    73. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon J, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 08; 24(5):759-770. PMID: 17157258.
      View in: PubMed
    74. Worby CA, Gentry MS, Dixon J. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. PMID: 16901901; PMCID: PMC2774450.
    75. Robinson FL, Dixon J. Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 2006 Aug; 16(8):403-12. PMID: 16828287.
      View in: PubMed
    76. Paulsen MT, Starks AM, Derheimer FA, Hanasoge S, Li L, Dixon J, Ljungman M. The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer. 2006 Jun 19; 5:25. PMID: 16784539; PMCID: PMC1524803.
    77. Worby CA, Dixon J. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. PMID: 16731519.
      View in: PubMed
    78. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon J. Identification of a bacterial type III effector family with G protein mimicry functions. Cell. 2006 Jan 13; 124(1):133-45. PMID: 16413487.
      View in: PubMed
    79. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon J. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):927-32. PMID: 16410353; PMCID: PMC1347996.
    80. Juris SJ, Shah K, Shokat K, Dixon J, Vacratsis PO. Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett. 2006 Jan 09; 580(1):179-83. PMID: 16364312.
      View in: PubMed
    81. Pagliarini DJ, Dixon J. Mitochondrial modulation: reversible phosphorylation takes center stage? Trends Biochem Sci. 2006 Jan; 31(1):26-34. PMID: 16337125.
      View in: PubMed
    82. Begley MJ, Dixon J. The structure and regulation of myotubularin phosphatases. Curr Opin Struct Biol. 2005 Dec; 15(6):614-20. PMID: 16289848.
      View in: PubMed
    83. Worby CA, Dixon J. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. PMID: 16249522.
      View in: PubMed
    84. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon J. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. PMID: 16039589.
      View in: PubMed
    85. Robinson FL, Dixon J. The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2005 Sep 09; 280(36):31699-707. PMID: 15998640.
      View in: PubMed
    86. Gentry MS, Worby CA, Dixon J. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. PMID: 15930137; PMCID: PMC1150849.
    87. Navarro L, Alto NM, Dixon J. Functions of the Yersinia effector proteins in inhibiting host immune responses. Curr Opin Microbiol. 2005 Feb; 8(1):21-7. PMID: 15694853.
      View in: PubMed
    88. Pagliarini DJ, Worby CA, Dixon J. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. PMID: 15247229.
      View in: PubMed
    89. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11; 117(6):699-711. PMID: 15186772.
      View in: PubMed
    90. Maehama T, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon J, Kanaho Y. Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Lett. 2004 May 07; 565(1-3):43-7. PMID: 15135050.
      View in: PubMed
    91. Worby CA, Dixon J. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. PMID: 18265350.
      View in: PubMed
    92. Taylor GS, Dixon J. Assaying phosphoinositide phosphatases. Methods Mol Biol. 2004; 284:217-27. PMID: 15173619.
      View in: PubMed
    93. Zhu M, Shao F, Innes RW, Dixon J, Xu Z. The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):302-7. PMID: 14694194; PMCID: PMC314180.
    94. Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon J, Stuckey JA. Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol Cell. 2003 Dec; 12(6):1391-402. PMID: 14690594.
      View in: PubMed
    95. Shao F, Golstein C, Ade J, Stoutemyer M, Dixon J, Innes RW. Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science. 2003 Aug 29; 301(5637):1230-3. PMID: 12947197.
      View in: PubMed
    96. Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon J, Firtel RA. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem. 2003 Oct 10; 278(41):39866-73. PMID: 12878591.
      View in: PubMed
    97. Das S, Dixon J, Cho W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7491-6. PMID: 12808147; PMCID: PMC164614.
    98. Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon J. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4492-7. PMID: 12668758; PMCID: PMC153583.
    99. McDonald C, Vacratsis PO, Bliska JB, Dixon J. The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem. 2003 May 16; 278(20):18514-23. PMID: 12626518.
      View in: PubMed
    100. Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon J. Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):904-9. PMID: 12538863; PMCID: PMC298699.
    101. Shao F, Dixon J. YopT is a cysteine protease cleaving Rho family GTPases. Adv Exp Med Biol. 2003; 529:79-84. PMID: 12756732.
      View in: PubMed
    102. Taylor GS, Dixon J. PTEN and myotubularins: families of phosphoinositide phosphatases. Methods Enzymol. 2003; 366:43-56. PMID: 14674238.
      View in: PubMed
    103. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon J, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
      View in: PubMed
    104. Worby CA, Dixon J. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. PMID: 12461558.
      View in: PubMed
    105. Wishart MJ, Dixon J. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol. 2002 Dec; 12(12):579-85. PMID: 12495846.
      View in: PubMed
    106. Muda M, Worby CA, Simonson-Leff N, Clemens JC, Dixon J. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. PMID: 12014990; PMCID: PMC1222762.
    107. Shao F, Merritt PM, Bao Z, Innes RW, Dixon J. A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 2002 May 31; 109(5):575-88. PMID: 12062101.
      View in: PubMed
    108. Hinnebusch BJ, Rudolph AE, Cherepanov P, Dixon J, Schwan TG, Forsberg A. Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. Science. 2002 Apr 26; 296(5568):733-5. PMID: 11976454.
      View in: PubMed
    109. Juris SJ, Shao F, Dixon J. Yersinia effectors target mammalian signalling pathways. Cell Microbiol. 2002 Apr; 4(4):201-11. PMID: 11952637.
      View in: PubMed
    110. Wishart MJ, Dixon J. The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2112-7. PMID: 11842224; PMCID: PMC122327.
    111. Kruger RP, Winter HC, Simonson-Leff N, Stuckey JA, Goldstein IJ, Dixon J. Cloning, expression, and characterization of the Galalpha 1,3Gal high affinity lectin from the mushroom Marasmius oreades. J Biol Chem. 2002 Apr 26; 277(17):15002-5. PMID: 11836254.
      View in: PubMed
    112. Worby CA, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon J. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. PMID: 11773052.
      View in: PubMed
    113. Wang J, Stuckey JA, Wishart MJ, Dixon J. A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen. J Biol Chem. 2002 Jan 25; 277(4):2377-80. PMID: 11739371.
      View in: PubMed
    114. Kim SA, Taylor GS, Torgersen KM, Dixon J. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2002 Feb 08; 277(6):4526-31. PMID: 11733541.
      View in: PubMed
    115. Mayo LD, Dixon J, Durden DL, Tonks NK, Donner DB. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2002 Feb 15; 277(7):5484-9. PMID: 11729185.
      View in: PubMed