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Jack Dixon

Title(s)Professor, Cellular and Molecular Medicine
SchoolHealth Sciences
Phone858-822-0491
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    Collapse Research 
    Collapse Research Activities and Funding
    Lafora epilepsy mechanisms: insights into brain metabolism
    NIH/NINDS R13NS096928May 1, 2016 - Apr 30, 2017
    Role: Principal Investigator
    YopT: A Yersinia Virulence Factor
    NIH/NIAID R21AI064614Apr 15, 2005 - Mar 31, 2007
    Role: Principal Investigator
    Fic-mediated Adenylylation
    NIH/NIGMS R01GM090328May 15, 2004 - Jul 31, 2014
    Role: Principal Investigator
    Molecular Mechanism of Pathogenesis
    NIH/NIAID R01AI060662May 15, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Conference: Second Messengers &Protein Phosphorylation
    NIH/NIDDK R13DK060093Jun 1, 2001 - May 31, 2002
    Role: Principal Investigator
    FASEB SUMMER CONFERENCE--RECEPTORS/SIGNAL TRANSDUCTION
    NIH/NIDDK R13DK058154Jul 17, 2000 - Jun 30, 2001
    Role: Principal Investigator
    MODEL 370A-01 AUTOMATED DNA SEQUENCER SYSTEM
    NIH/NCRR S10RR004849Jul 20, 1989 - Jan 19, 1991
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    EUCARYOTIC METABOLIC REGULATION
    NIH/NIDDK T32DK007532Dec 1, 1986 - Nov 30, 1997
    Role: Principal Investigator
    National Biomedical NMR Resource at Madison
    NIH P41RR002301Jul 1, 1985 - Feb 28, 2015
    Role: Co-Investigator
    Gastointestinal Hormone Research Core Center
    NIH P30DK034933Sep 30, 1984 - Nov 30, 2016
    Role: Co-Investigator
    ENDOCRINOLOGY STUDY SECTION
    NIH/CSR U09RG011666Jul 1, 1984 - Jun 30, 1991
    Role: Principal Investigator
    Novel Secreted Kinases
    NIH/NIDDK R01DK018024Jun 1, 1979 - Jul 31, 2019
    Role: Principal Investigator
    Phosphoinositide Phosphatases
    NIH/NIDDK R37DK018024Jun 1, 1979 - Jul 31, 2014
    Role: Principal Investigator
    STUDIES ON PANCREATIC HORMONES
    NIH/NIADDK R01AM018024Jun 1, 1979 - May 31, 1988
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000042Dec 1, 1977 - Feb 28, 2011
    Role: Co-Investigator
    Michigan Diabetes Research and Training Center
    NIH P60DK020572Sep 1, 1977 - Feb 9, 2013
    Role: Co-Investigator
    Regulation and Function of the Secretory Phosphoproteome
    NIH/NIDDK R01DK018849May 1, 1976 - Jun 30, 2021
    Role: Principal Investigator
    REGULATION OF NEUROPEPTIDE BIOSYNTHESIS
    NIH/NIADDK R01AM018849May 1, 1976 - Jun 30, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Worby CA, Dixon JE. Reversible phosphorylation: a birthday tribute to Herb Tabor. J Biol Chem. 2019 02 01; 294(5):1638-1642. PMID: 30710011.
      View in: PubMed
    2. Pollak AJ, Liu C, Gudlur A, Mayfield JE, Dalton ND, Gu Y, Chen J, Heller Brown J, Hogan PG, Wiley SE, Peterson KL, Dixon JE. A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. Elife. 2018 12 06; 7. PMID: 30520731.
      View in: PubMed
    3. Qiu Y, Poppleton E, Mekkat A, Yu H, Banerjee S, Wiley SE, Dixon JE, Kaplan DL, Lin YS, Brodsky B. Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide. Biophys J. 2018 Dec 18; 115(12):2327-2335. PMID: 30527445.
      View in: PubMed
    4. Banerjee S, Ji C, Mayfield JE, Goel A, Xiao J, Dixon JE, Guo X. Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8155-8160. PMID: 29987021.
      View in: PubMed
    5. Zhang H, Zhu Q, Cui J, Wang Y, Chen MJ, Guo X, Tagliabracci VS, Dixon JE, Xiao J. Structure and evolution of the Fam20 kinases. Nat Commun. 2018 03 23; 9(1):1218. PMID: 29572475.
      View in: PubMed
    6. Pollak AJ, Haghighi K, Kunduri S, Arvanitis DA, Bidwell PA, Liu GS, Singh VP, Gonzalez DJ, Sanoudou D, Wiley SE, Dixon JE, Kranias EG. Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):9098-9103. PMID: 28784772.
      View in: PubMed
    7. Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. Elife. 2017 04 22; 6. PMID: 28432788.
      View in: PubMed
    8. Chen MJ, Dixon JE, Manning G. Genomics and evolution of protein phosphatases. Sci Signal. 2017 Apr 11; 10(474). PMID: 28400531.
      View in: PubMed
    9. Wang X, Cimermancic P, Yu C, Schweitzer A, Chopra N, Engel JL, Greenberg C, Huszagh AS, Beck F, Sakata E, Yang Y, Novitsky EJ, Leitner A, Nanni P, Kahraman A, Guo X, Dixon JE, Rychnovsky SD, Aebersold R, Baumeister W, Sali A, Huang L. Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol Cell Proteomics. 2017 05; 16(5):840-854. PMID: 28292943.
      View in: PubMed
    10. Zhu Q, Venzke D, Walimbe AS, Anderson ME, Fu Q, Kinch LN, Wang W, Chen X, Grishin NV, Huang N, Yu L, Dixon JE, Campbell KP, Xiao J. Structure of protein O-mannose kinase reveals a unique active site architecture. Elife. 2016 11 23; 5. PMID: 27879205.
      View in: PubMed
    11. Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS. Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3482-91. PMID: 27185916; PMCID: PMC4922149 [Available on 12/21/16].
    12. Coles RJ, Price DM, Dixon JE, Royall B, Clarke E, Kok P, Skolnick MS, Fox AM, Makhonin MN. Chirality of nanophotonic waveguide with embedded quantum emitter for unidirectional spin transfer. Nat Commun. 2016 Mar 31; 7:11183. PMID: 27029961.
      View in: PubMed
    13. Guo X, Dixon JE. The 26S proteasome: A cell cycle regulator regulated by cell cycle. Cell Cycle. 2016; 15(7):875-6. PMID: 26940127; PMCID: PMC4889267 [Available on 03/03/17].
    14. Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016 Feb; 18(2):202-12. PMID: 26655835; PMCID: PMC4844191.
    15. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE. A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18; 161(7):1619-32. PMID: 26091039; PMCID: PMC4963185.
    16. Cozza G, Salvi M, Banerjee S, Tibaldi E, Tagliabracci VS, Dixon JE, Pinna LA. A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins. Biochim Biophys Acta. 2015 Oct; 1854(10 Pt B):1718-26. PMID: 25936777.
      View in: PubMed
    17. He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase. Bioorg Med Chem. 2015 Jun 15; 23(12):2798-809. PMID: 25907364; PMCID: PMC4451428.
    18. Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M, Dixon JE. A secretory kinase complex regulates extracellular protein phosphorylation. Elife. 2015 Mar 19; 4:e06120. PMID: 25789606; PMCID: PMC4421793.
    19. Wen J, Xiao J, Rahdar M, Choudhury BP, Cui J, Taylor GS, Esko JD, Dixon JE. Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15723-8. PMID: 25331875; PMCID: PMC4226115.
    20. Worby CA, Dixon JE. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-1224. PMID: 25215479.
      View in: PubMed
    21. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
    22. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5520-5. PMID: 24706917; PMCID: PMC3992636.
    23. Gonzalez DJ, Vuong L, Gonzalez IS, Keller N, McGrosso D, Hwang JH, Hung J, Zinkernagel A, Dixon JE, Dorrestein PC, Nizet V. Phenol soluble modulin (PSM) variants of community-associated methicillin-resistant Staphylococcus aureus (MRSA) captured using mass spectrometry-based molecular networking. Mol Cell Proteomics. 2014 May; 13(5):1262-72. PMID: 24567418; PMCID: PMC4014283.
    24. Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon JE, Mirny LA, Mukherjee S, Reizis B. ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia. Cell Rep. 2014 Feb 13; 6(3):528-40. PMID: 24485662; PMCID: PMC3936793.
    25. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. PMID: 24449268; PMCID: PMC3909786.
    26. Worby CA, Dixon JE. PTEN. Annu Rev Biochem. 2014; 83:641-69. PMID: 24905788.
      View in: PubMed
    27. Qi D, Dubiella U, Kim SH, Sloss DI, Dowen RH, Dixon JE, Innes RW. Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1. Plant Physiol. 2014 Jan; 164(1):340-51. PMID: 24225654; PMCID: PMC3875812.
    28. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 04; 79(5):903-16. PMID: 24012004; PMCID: PMC3779136.
    29. Tagliabracci VS, Pinna LA, Dixon JE. Response to Wang et al.: Secreted protein kinases? Trends Biochem Sci. 2013 Sep; 38(9):425. PMID: 23992948.
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    30. Tagliabracci VS, Xiao J, Dixon JE. Phosphorylation of substrates destined for secretion by the Fam20 kinases. Biochem Soc Trans. 2013 Aug; 41(4):1061-5. PMID: 23863179.
      View in: PubMed
    31. Xiao J, Tagliabracci VS, Wen J, Kim SA, Dixon JE. Crystal structure of the Golgi casein kinase. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10574-9. PMID: 23754375; PMCID: PMC3696822.
    32. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906; PMCID: PMC3779451.
    33. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013 Feb 15; 288(7):5176-85. PMID: 23293031; PMCID: PMC3576122.
    34. Tagliabracci VS, Pinna LA, Dixon JE. Secreted protein kinases. Trends Biochem Sci. 2013 Mar; 38(3):121-30. PMID: 23276407; PMCID: PMC3582740.
    35. Dowen RH, Pelizzola M, Schmitz RJ, Lister R, Dowen JM, Nery JR, Dixon JE, Ecker JR. Widespread dynamic DNA methylation in response to biotic stress. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):E2183-91. PMID: 22733782; PMCID: PMC3420206.
    36. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 01; 336(6085):1150-3. PMID: 22582013; PMCID: PMC3754843.
    37. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20; 287(17):13889-98. PMID: 22371493; PMCID: PMC3340166.
    38. Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon JE, Goodman JM. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012 Jan 27; 287(5):3123-37. PMID: 22134922; PMCID: PMC3283218.
    39. Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18649-54. PMID: 21949367; PMCID: PMC3219150.
    40. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. PMID: 21795713; PMCID: PMC3173180.
    41. Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon JE. Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11860-5. PMID: 21730175; PMCID: PMC3142007.
    42. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 08; 13(6):690-700. PMID: 21641550; PMCID: PMC3119201.
    43. Pei J, Mitchell DA, Dixon JE, Grishin NV. Expansion of type II CAAX proteases reveals evolutionary origin of ?-secretase subunit APH-1. J Mol Biol. 2011 Jul 01; 410(1):18-26. PMID: 21570408; PMCID: PMC3155266.
    44. Worby CA, Dixon JE. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 02; 13(3):233-4. PMID: 21356510.
      View in: PubMed
    45. Okamura Y, Dixon JE. Voltage-sensing phosphatase: its molecular relationship with PTEN. Physiology (Bethesda). 2011 Feb; 26(1):6-13. PMID: 21357898.
      View in: PubMed
    46. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. PMID: 20622875; PMCID: PMC2920259.
    47. Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 03; 285(36):28220-8. PMID: 20581111; PMCID: PMC2934687.
    48. Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE, Wu C, Wunsch C, Zoback ML. Climate change and the integrity of science. Science. 2010 May 07; 328(5979):689-90. PMID: 20448167.
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    49. Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel JP, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Sci. 2010 May; 19(5):974-86. PMID: 20222012.
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    50. Doughty-Shenton D, Joseph JD, Zhang J, Pagliarini DJ, Kim Y, Lu D, Dixon JE, Casey PJ. Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J Pharmacol Exp Ther. 2010 May; 333(2):584-92. PMID: 20167843.
      View in: PubMed
    51. Gentry MS, Dixon JE, Worby CA. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. PMID: 19818631.
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    52. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. PMID: 19362538; PMCID: PMC2820730.
    53. Dowen RH, Engel JL, Shao F, Ecker JR, Dixon JE. A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes. J Biol Chem. 2009 Jun 05; 284(23):15867-79. PMID: 19346252; PMCID: PMC2708883.
    54. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. PMID: 19341700; PMCID: PMC2713743.
    55. Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem. 2009 May 08; 284(19):13004-12. PMID: 19286651; PMCID: PMC2676033.
    56. Wiley SE, Rardin MJ, Dixon JE. Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET. Methods Enzymol. 2009; 456:233-46. PMID: 19348892.
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    57. Rardin MJ, Taylor GS, Dixon JE. Distinguishing mitochondrial inner membrane orientation of dual specific phosphatase 18 and 21. Methods Enzymol. 2009; 457:275-87. PMID: 19426873.
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    58. Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI. Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation. Cell Host Microbe. 2008 Nov 13; 4(5):434-46. PMID: 18996344; PMCID: PMC2658612.
    59. Geertsema RS, Worby C, Kruger RP, Tagawa Y, Russo R, Herdman DS, Lo K, Kimball RA, Dixon J, Corbeil LB. Protection of mice against H. somni septicemia by vaccination with recombinant immunoglobulin binding protein subunits. Vaccine. 2008 Aug 18; 26(35):4506-12. PMID: 18590787; PMCID: PMC2659705.
    60. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. PMID: 18524949; PMCID: PMC2430346.
    61. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008 May 30; 283(22):15440-50. PMID: 18385140; PMCID: PMC2397459.
    62. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. PMID: 18375757; PMCID: PMC2311365.
    63. Robinson FL, Niesman IR, Beiswenger KK, Dixon JE. Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4916-21. PMID: 18349142; PMCID: PMC2290800.
    64. Mattoo S, Alto NM, Dixon JE. Subversion of myosin function by E. coli. Dev Cell. 2008 Jan; 14(1):8-10. PMID: 18194648.
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    65. Alto NM, Dixon JE. Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins. Methods Enzymol. 2008; 439:131-43. PMID: 18374161.
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    66. Worby CA, Gentry MS, Dixon JE. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. PMID: 18070875; PMCID: PMC2251628.
    67. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. PMID: 17908927; PMCID: PMC1993871.
    68. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247; PMCID: PMC2064658.
    69. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14342-7. PMID: 17766440; PMCID: PMC1963346.
    70. Faucherre A, Taylor GS, Overvoorde J, Dixon JE, Hertog Jd. Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development. Oncogene. 2008 Feb 14; 27(8):1079-86. PMID: 17704803.
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    72. Gentry MS, Dowen RH, Worby CA, Mattoo S, Ecker JR, Dixon JE. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. PMID: 17646401; PMCID: PMC2064834.
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    75. Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. Identification of a molecular target for the Yersinia protein kinase A. Mol Cell. 2007 May 25; 26(4):465-77. PMID: 17531806.
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    76. Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC, Dixon JE. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6596-601. PMID: 17420445; PMCID: PMC1871831.
    77. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5318-23. PMID: 17376863; PMCID: PMC1838440.
    78. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. PMID: 17355171; PMCID: PMC1821046.
    79. Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol Cell. 2006 Dec 08; 24(5):759-770. PMID: 17157258.
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    80. Worby CA, Gentry MS, Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. PMID: 16901901; PMCID: PMC2774450.
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    82. Paulsen MT, Starks AM, Derheimer FA, Hanasoge S, Li L, Dixon JE, Ljungman M. The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer. 2006 Jun 19; 5:25. PMID: 16784539.
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    83. Worby CA, Dixon JE. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. PMID: 16731519.
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    84. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. Identification of a bacterial type III effector family with G protein mimicry functions. Cell. 2006 Jan 13; 124(1):133-45. PMID: 16413487.
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    85. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):927-32. PMID: 16410353.
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    86. Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO. Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry. FEBS Lett. 2006 Jan 09; 580(1):179-83. PMID: 16364312.
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    87. Pagliarini DJ, Dixon JE. Mitochondrial modulation: reversible phosphorylation takes center stage? Trends Biochem Sci. 2006 Jan; 31(1):26-34. PMID: 16337125.
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    88. Begley MJ, Dixon JE. The structure and regulation of myotubularin phosphatases. Curr Opin Struct Biol. 2005 Dec; 15(6):614-20. PMID: 16289848.
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    89. Worby CA, Dixon JE. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. PMID: 16249522.
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    90. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. PMID: 16039589.
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    91. Robinson FL, Dixon JE. The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2005 Sep 09; 280(36):31699-707. PMID: 15998640.
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    92. Gentry MS, Worby CA, Dixon JE. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. PMID: 15930137; PMCID: PMC1150849.
    93. Navarro L, Alto NM, Dixon JE. Functions of the Yersinia effector proteins in inhibiting host immune responses. Curr Opin Microbiol. 2005 Feb; 8(1):21-7. PMID: 15694853.
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    94. Pagliarini DJ, Worby CA, Dixon JE. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. PMID: 15247229.
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    95. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell. 2004 Jun 11; 117(6):699-711. PMID: 15186772.
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    96. Maehama T, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon JE, Kanaho Y. Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN. FEBS Lett. 2004 May 07; 565(1-3):43-7. PMID: 15135050.
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    97. Worby CA, Dixon JE. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. PMID: 18265350.
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    98. Taylor GS, Dixon JE. Assaying phosphoinositide phosphatases. Methods Mol Biol. 2004; 284:217-27. PMID: 15173619.
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    99. Zhu M, Shao F, Innes RW, Dixon JE, Xu Z. The crystal structure of Pseudomonas avirulence protein AvrPphB: a papain-like fold with a distinct substrate-binding site. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):302-7. PMID: 14694194.
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    100. Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA. Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol Cell. 2003 Dec; 12(6):1391-402. PMID: 14690594.
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    101. Shao F, Golstein C, Ade J, Stoutemyer M, Dixon JE, Innes RW. Cleavage of Arabidopsis PBS1 by a bacterial type III effector. Science. 2003 Aug 29; 301(5637):1230-3. PMID: 12947197.
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    102. Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon JE, Firtel RA. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem. 2003 Oct 10; 278(41):39866-73. PMID: 12878591.
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    103. Das S, Dixon JE, Cho W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7491-6. PMID: 12808147; PMCID: PMC164614.
    104. Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE. Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4492-7. PMID: 12668758; PMCID: PMC153583.
    105. McDonald C, Vacratsis PO, Bliska JB, Dixon JE. The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases. J Biol Chem. 2003 May 16; 278(20):18514-23. PMID: 12626518.
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    106. Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):904-9. PMID: 12538863; PMCID: PMC298699.
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    108. Taylor GS, Dixon JE. PTEN and myotubularins: families of phosphoinositide phosphatases. Methods Enzymol. 2003; 366:43-56. PMID: 14674238.
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    109. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
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    110. Worby CA, Dixon JE. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. PMID: 12461558.
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    111. Wishart MJ, Dixon JE. PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease. Trends Cell Biol. 2002 Dec; 12(12):579-85. PMID: 12495846.
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    112. Muda M, Worby CA, Simonson-Leff N, Clemens JC, Dixon JE. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. PMID: 12014990; PMCID: PMC1222762.
    113. Shao F, Merritt PM, Bao Z, Innes RW, Dixon JE. A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. Cell. 2002 May 31; 109(5):575-88. PMID: 12062101.
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    114. Hinnebusch BJ, Rudolph AE, Cherepanov P, Dixon JE, Schwan TG, Forsberg A. Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector. Science. 2002 Apr 26; 296(5568):733-5. PMID: 11976454.
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    115. Juris SJ, Shao F, Dixon JE. Yersinia effectors target mammalian signalling pathways. Cell Microbiol. 2002 Apr; 4(4):201-11. PMID: 11952637.
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    116. Wishart MJ, Dixon JE. The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2112-7. PMID: 11842224.
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    117. Kruger RP, Winter HC, Simonson-Leff N, Stuckey JA, Goldstein IJ, Dixon JE. Cloning, expression, and characterization of the Galalpha 1,3Gal high affinity lectin from the mushroom Marasmius oreades. J Biol Chem. 2002 Apr 26; 277(17):15002-5. PMID: 11836254.
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    118. Worby CA, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon JE. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. PMID: 11773052.
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    119. Wang J, Stuckey JA, Wishart MJ, Dixon JE. A unique carbohydrate binding domain targets the lafora disease phosphatase to glycogen. J Biol Chem. 2002 Jan 25; 277(4):2377-80. PMID: 11739371.
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    120. Kim SA, Taylor GS, Torgersen KM, Dixon JE. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2002 Feb 08; 277(6):4526-31. PMID: 11733541.
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    121. Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2002 Feb 15; 277(7):5484-9. PMID: 11729185.
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    122. Worby CA, Simonson-Leff N, Clemens JC, Kruger RP, Muda M, Dixon JE. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. J Biol Chem. 2001 Nov 09; 276(45):41782-9. PMID: 11546816.
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    123. Worby CA, Simonson-Leff N, Dixon JE. RNA interference of gene expression (RNAi) in cultured Drosophila cells. Sci STKE. 2001 Aug 14; 2001(95):pl1. PMID: 11752672.
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    124. Taylor GS, Dixon JE. An assay for phosphoinositide phosphatases utilizing fluorescent substrates. Anal Biochem. 2001 Aug 01; 295(1):122-6. PMID: 11476556.
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    125. Wishart MJ, Taylor GS, Dixon JE. Phoxy lipids: revealing PX domains as phosphoinositide binding modules. Cell. 2001 Jun 29; 105(7):817-20. PMID: 11439176.
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    126. Gustin JA, Maehama T, Dixon JE, Donner DB. The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem. 2001 Jul 20; 276(29):27740-4. PMID: 11356844.
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    127. Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4640-5. PMID: 11287630.
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    128. Abe MK, Kahle KT, Saelzler MP, Orth K, Dixon JE, Rosner MR. ERK7 is an autoactivated member of the MAPK family. J Biol Chem. 2001 Jun 15; 276(24):21272-9. PMID: 11287416.
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    129. Wishart MJ, Taylor GS, Slama JT, Dixon JE. PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench. Curr Opin Cell Biol. 2001 Apr; 13(2):172-81. PMID: 11248551.
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    130. Pan Z, Selyanko AA, Hadley JK, Brown DA, Dixon JE, McKinnon D. Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. J Physiol. 2001 Mar 01; 531(Pt 2):347-58. PMID: 11230508.
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    131. Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem. 2001; 70:247-79. PMID: 11395408.
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    132. Orth K, Xu Z, Mudgett MB, Bao ZQ, Palmer LE, Bliska JB, Mangel WF, Staskawicz B, Dixon JE. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science. 2000 Nov 24; 290(5496):1594-7. PMID: 11090361.
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    133. Maehama T, Dixon JE. [PTEN tumor suppressor: functions as a lipid phosphatase]. Tanpakushitsu Kakusan Koso. 2000 Oct; 45(14):2405-14. PMID: 11051842.
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    134. Juris SJ, Rudolph AE, Huddler D, Orth K, Dixon JE. A distinctive role for the Yersinia protein kinase: actin binding, kinase activation, and cytoskeleton disruption. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9431-6. PMID: 10920208.
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    135. Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds. J Mol Biol. 2000 Aug 11; 301(2):433-50. PMID: 10926519.
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    136. Taylor GS, Maehama T, Dixon JE. Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8910-5. PMID: 10900271.
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    137. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 09; 101(6):671-84. PMID: 10892653.
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    138. Clemens JC, Worby CA, Simonson-Leff N, Muda M, Maehama T, Hemmings BA, Dixon JE. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6499-503. PMID: 10823906.
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    139. Ratcliffe CF, Qu Y, McCormick KA, Tibbs VC, Dixon JE, Scheuer T, Catterall WA. A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Nat Neurosci. 2000 May; 3(5):437-44. PMID: 10769382.
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    140. Maehama T, Taylor GS, Slama JT, Dixon JE. A sensitive assay for phosphoinositide phosphatases. Anal Biochem. 2000 Mar 15; 279(2):248-50. PMID: 10706796.
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    141. Ignatoski KM, Maehama T, Markwart SM, Dixon JE, Livant DL, Ethier SP. ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells. Br J Cancer. 2000 Feb; 82(3):666-74. PMID: 10682681.
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    142. Li L, Dixon JE. Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases. Semin Immunol. 2000 Feb; 12(1):75-84. PMID: 10723800.
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    143. Li L, Ljungman M, Dixon JE. The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J Biol Chem. 2000 Jan 28; 275(4):2410-4. PMID: 10644693.
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    144. Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999 Oct 29; 99(3):323-34. PMID: 10555148.
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    145. Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE. Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science. 1999 Sep 17; 285(5435):1920-3. PMID: 10489373.
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    146. Muda M, Manning ER, Orth K, Dixon JE. Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function. J Biol Chem. 1999 Aug 20; 274(34):23991-5. PMID: 10446167.
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    147. Shi W, Wymore R, Yu H, Wu J, Wymore RT, Pan Z, Robinson RB, Dixon JE, McKinnon D, Cohen IS. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res. 1999 Jul 09; 85(1):e1-6. PMID: 10400919.
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    148. Rudolph AE, Stuckey JA, Zhao Y, Matthews HR, Patton WA, Moss J, Dixon JE. Expression, characterization, and mutagenesis of the Yersinia pestis murine toxin, a phospholipase D superfamily member. J Biol Chem. 1999 Apr 23; 274(17):11824-31. PMID: 10207000.
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    149. Gao J, Wymore R, Wymore RT, Wang Y, McKinnon D, Dixon JE, Mathias RT, Cohen IS, Baldo GJ. Isoform-specific regulation of the sodium pump by alpha- and beta-adrenergic agonists in the guinea-pig ventricle. J Physiol. 1999 Apr 15; 516 ( Pt 2):377-83. PMID: 10087338.
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    150. Yu H, McKinnon D, Dixon JE, Gao J, Wymore R, Cohen IS, Danilo P, Shvilkin A, Anyukhovsky EP, Sosunov EA, Hara M, Rosen MR. Transient outward current, Ito1, is altered in cardiac memory. Circulation. 1999 Apr 13; 99(14):1898-905. PMID: 10199889.
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    151. Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 1999 Apr; 9(4):125-8. PMID: 10203785.
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    152. Stuckey JA, Dixon JE. Crystal structure of a phospholipase D family member. Nat Struct Biol. 1999 Mar; 6(3):278-84. PMID: 10074947.
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    153. Lee TT, Worby C, Bao ZQ, Dixon JE, Colman RF. His68 and His141 are critical contributors to the intersubunit catalytic site of adenylosuccinate lyase of Bacillus subtilis. Biochemistry. 1999 Jan 05; 38(1):22-32. PMID: 9890879.
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    154. Denu JM, Dixon JE. Protein tyrosine phosphatases: mechanisms of catalysis and regulation. Curr Opin Chem Biol. 1998 Oct; 2(5):633-41. PMID: 9818190.
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    155. Shi W, Wang HS, Pan Z, Wymore RS, Cohen IS, McKinnon D, Dixon JE. Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. J Physiol. 1998 Sep 15; 511 ( Pt 3):675-82. PMID: 9714851.
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    156. Gottlin EB, Rudolph AE, Zhao Y, Matthews HR, Dixon JE. Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9202-7. PMID: 9689058.
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    157. Wishart MJ, Dixon JE. Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains. Trends Biochem Sci. 1998 Aug; 23(8):301-6. PMID: 9757831.
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    158. Deb TB, Wong L, Salomon DS, Zhou G, Dixon JE, Gutkind JS, Thompson SA, Johnson GR. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation. J Biol Chem. 1998 Jul 03; 273(27):16643-6. PMID: 9642214.
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    159. Lee TT, Worby C, Bao ZQ, Dixon JE, Colman RF. Implication of His68 in the substrate site of Bacillus subtilis adenylosuccinate lyase by mutagenesis and affinity labeling with 2-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-monophosphate. Biochemistry. 1998 Jun 09; 37(23):8481-9. PMID: 9622500.
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    160. Bell SD, Denu JM, Dixon JE, Ellington AD. RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase. J Biol Chem. 1998 Jun 05; 273(23):14309-14. PMID: 9603938.
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    161. Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998 May 29; 273(22):13375-8. PMID: 9593664.
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    162. Worby CA, Vega QC, Chao HH, Seasholtz AF, Thompson RC, Dixon JE. Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem. 1998 Feb 06; 273(6):3502-8. PMID: 9452475.
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    163. Zhao Y, Stuckey JA, Lohse DL, Dixon JE. Expression, characterization, and crystallization of a member of the novel phospholipase D family of phosphodiesterases. Protein Sci. 1997 Dec; 6(12):2655-8. PMID: 9416618.
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    164. Zhuo S, Dixon JE. Effects of sulfhydryl regents on the activity of lambda Ser/Thr phosphoprotein phosphatase and inhibition of the enzyme by zinc ion. Protein Eng. 1997 Dec; 10(12):1445-52. PMID: 9543006.
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    165. Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem. 1997 Nov 21; 272(47):29403-6. PMID: 9367992.
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    166. Ursuliak Z, Clemens JC, Dixon JE, Price JV. Differential accumulation of DPTP61F alternative transcripts: regulation of a protein tyrosine phosphatase by segmentation genes. Mech Dev. 1997 Jul; 65(1-2):19-30. PMID: 9256342.
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    167. Fitzgerald LR, Walton KM, Dixon JE, Largent BL. PTP NE-6: a brain-enriched receptor-type protein tyrosine phosphatase with a divergent catalytic domain. J Neurochem. 1997 May; 68(5):1820-9. PMID: 9109506.
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    168. Lohse DL, Denu JM, Santoro N, Dixon JE. Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1. Biochemistry. 1997 Apr 15; 36(15):4568-75. PMID: 9109666.
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    169. Ernsting BR, Dixon JE. The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle. J Biol Chem. 1997 Apr 04; 272(14):9332-43. PMID: 9083070.
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    170. Wymore RS, Gintant GA, Wymore RT, Dixon JE, McKinnon D, Cohen IS. Tissue and species distribution of mRNA for the IKr-like K+ channel, erg. Circ Res. 1997 Feb; 80(2):261-8. PMID: 9012748.
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    171. Lee TT, Worby C, Dixon JE, Colman RF. Identification of His141 in the active site of Bacillus subtilis adenylosuccinate lyase by affinity labeling with 6-(4-bromo-2,3-dioxobutyl)thioadenosine 5'-monophosphate. J Biol Chem. 1997 Jan 03; 272(1):458-65. PMID: 8995283.
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    172. Wiland AM, Denu JM, Mourey RJ, Dixon JE. Purification and kinetic characterization of the mitogen-activated protein kinase phosphatase rVH6. J Biol Chem. 1996 Dec 27; 271(52):33486-92. PMID: 8969212.
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    173. Gottlin EB, Xu X, Epstein DM, Burke SP, Eckstein JW, Ballou DP, Dixon JE. Kinetic analysis of the catalytic domain of human cdc25B. J Biol Chem. 1996 Nov 01; 271(44):27445-9. PMID: 8910325.
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    174. Denu JM, Stuckey JA, Saper MA, Dixon JE. Form and function in protein dephosphorylation. Cell. 1996 Nov 01; 87(3):361-4. PMID: 8898189.
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    175. Dixon JE, Shi W, Wang HS, McDonald C, Yu H, Wymore RS, Cohen IS, McKinnon D. Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res. 1996 Oct; 79(4):659-68. PMID: 8831489.
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    176. Vega QC, Worby CA, Lechner MS, Dixon JE, Dressler GR. Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10657-61. PMID: 8855235.
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    177. Worby CA, Vega QC, Zhao Y, Chao HH, Seasholtz AF, Dixon JE. Glial cell line-derived neurotrophic factor signals through the RET receptor and activates mitogen-activated protein kinase. J Biol Chem. 1996 Sep 27; 271(39):23619-22. PMID: 8798576.
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    178. Clemens JC, Ursuliak Z, Clemens KK, Price JV, Dixon JE. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. J Biol Chem. 1996 Jul 19; 271(29):17002-5. PMID: 8663600.
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    179. David M, Zhou G, Pine R, Dixon JE, Larner AC. The SH2 domain-containing tyrosine phosphatase PTP1D is required for interferon alpha/beta-induced gene expression. J Biol Chem. 1996 Jul 05; 271(27):15862-5. PMID: 8663536.
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    180. Hengge AC, Denu JM, Dixon JE. Transition-state structures for the native dual-specific phosphatase VHR and D92N and S131A mutants. Contributions to the driving force for catalysis. Biochemistry. 1996 Jun 04; 35(22):7084-92. PMID: 8679534.
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    181. Yuvaniyama J, Denu JM, Dixon JE, Saper MA. Crystal structure of the dual specificity protein phosphatase VHR. Science. 1996 May 31; 272(5266):1328-31. PMID: 8650541.
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    182. Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM. Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7. J Biol Chem. 1996 May 03; 271(18):10607-10. PMID: 8631863.
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    183. Redinbo MR, Eide SM, Stone RL, Dixon JE, Yeates TO. Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism. Protein Sci. 1996 Apr; 5(4):786-8. PMID: 8845770.
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    184. Denu JM, Lohse DL, Vijayalakshmi J, Saper MA, Dixon JE. Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2493-8. PMID: 8637902.
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    185. Liu X, Vega QC, Decker RA, Pandey A, Worby CA, Dixon JE. Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities. J Biol Chem. 1996 Mar 08; 271(10):5309-12. PMID: 8621380.
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    186. Mauro LJ, Olmsted EA, Davis AR, Dixon JE. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Endocrinology. 1996 Mar; 137(3):925-33. PMID: 8603605.
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    187. Mourey RJ, Vega QC, Campbell JS, Wenderoth MP, Hauschka SD, Krebs EG, Dixon JE. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. J Biol Chem. 1996 Feb 16; 271(7):3795-802. PMID: 8631996.
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    188. Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. J Biol Chem. 1996 Feb 09; 271(6):3265-71. PMID: 8621729.
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    189. Dixon JE. Protein tyrosine phosphatases: their roles in signal transduction. Recent Prog Horm Res. 1996; 51:405-14; discussion 415. PMID: 8701088.
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    190. Dixon JE, McKinnon D. Potassium channel mRNA expression in prevertebral and paravertebral sympathetic neurons. Eur J Neurosci. 1996 Jan; 8(1):183-91. PMID: 8713462.
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    191. Wishart MJ, Denu JM, Williams JA, Dixon JE. A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. J Biol Chem. 1995 Nov 10; 270(45):26782-5. PMID: 7592916.
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    192. Lohse DL, Denu JM, Dixon JE. Insights derived from the structures of the Ser/Thr phosphatases calcineurin and protein phosphatase 1. Structure. 1995 Oct 15; 3(10):987-90. PMID: 8590008.
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    193. Martell KJ, Seasholtz AF, Kwak SP, Clemens KK, Dixon JE. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. J Neurochem. 1995 Oct; 65(4):1823-33. PMID: 7561881.
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    194. Dixon JE. Structure and catalytic properties of protein tyrosine phosphatases. Ann N Y Acad Sci. 1995 Sep 07; 766:18-22. PMID: 7486654.
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    195. Schubert HL, Fauman EB, Stuckey JA, Dixon JE, Saper MA. A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase. Protein Sci. 1995 Sep; 4(9):1904-13. PMID: 8528087.
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    196. Denu JM, Dixon JE. A catalytic mechanism for the dual-specific phosphatases. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):5910-4. PMID: 7597052.
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    197. Zhou G, Bao ZQ, Dixon JE. Components of a new human protein kinase signal transduction pathway. J Biol Chem. 1995 May 26; 270(21):12665-9. PMID: 7759517.
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    198. Denu JM, Zhou G, Guo Y, Dixon JE. The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase. Biochemistry. 1995 Mar 14; 34(10):3396-403. PMID: 7880835.
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    199. Denu JM, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper MA, Dixon JE. The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem. 1995 Feb 24; 270(8):3796-803. PMID: 7876121.
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    200. Kwak SP, Dixon JE. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cell lines. J Biol Chem. 1995 Jan 20; 270(3):1156-60. PMID: 7836374.
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    201. Zhang ZY, Wang Y, Wu L, Fauman EB, Stuckey JA, Schubert HL, Saper MA, Dixon JE. The Cys(X)5Arg catalytic motif in phosphoester hydrolysis. Biochemistry. 1994 Dec 27; 33(51):15266-70. PMID: 7803389.
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    202. Stone RL, Dixon JE. Protein-tyrosine phosphatases. J Biol Chem. 1994 Dec 16; 269(50):31323-6. PMID: 7989293.
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    203. Mauro LJ, Olmsted EA, Skrobacz BM, Mourey RJ, Davis AR, Dixon JE. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. J Biol Chem. 1994 Dec 02; 269(48):30659-67. PMID: 7527035.
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    204. Ninfa EG, Dixon JE. Protein tyrosine phosphatases in disease processes. Trends Cell Biol. 1994 Dec; 4(12):427-30. PMID: 14731691.
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    205. Birch NP, Hakes DJ, Dixon JE, Mezey E. Distribution and regulation of the candidate prohormone processing enzymes SPC2 and SPC3 in adult rat brain. Neuropeptides. 1994 Dec; 27(6):307-22. PMID: 7898639.
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    206. Zhou G, Denu JM, Wu L, Dixon JE. The catalytic role of Cys124 in the dual specificity phosphatase VHR. J Biol Chem. 1994 Nov 11; 269(45):28084-90. PMID: 7961745.
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    207. Zhuo S, Clemens JC, Stone RL, Dixon JE. Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis. J Biol Chem. 1994 Oct 21; 269(42):26234-8. PMID: 7929339.
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    208. Dixon JE, Sadowski PD. Resolution of immobile chi structures by the FLP recombinase of 2 microns plasmid. J Mol Biol. 1994 Oct 21; 243(2):199-207. PMID: 7932750.
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    209. Stuckey JA, Schubert HL, Fauman EB, Zhang ZY, Dixon JE, Saper MA. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature. 1994 Aug 18; 370(6490):571-5. PMID: 8052312.
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    210. Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM. Chromosomal localization of four human VH1-like protein-tyrosine phosphatases. Genomics. 1994 Jul 15; 22(2):462-4. PMID: 7806236.
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    211. Mauro LJ, Dixon JE. 'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'. Trends Biochem Sci. 1994 Apr; 19(4):151-5. PMID: 8016862.
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    212. Zhang ZY, Malachowski WP, Van Etten RL, Dixon JE. Nature of the rate-determining steps of the reaction catalyzed by the Yersinia protein-tyrosine phosphatase. J Biol Chem. 1994 Mar 18; 269(11):8140-5. PMID: 8132539.
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    213. Zhang ZY, Maclean D, McNamara DJ, Sawyer TK, Dixon JE. Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates. Biochemistry. 1994 Mar 01; 33(8):2285-90. PMID: 7509638.
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    214. Zhang ZY, Wang Y, Dixon JE. Dissecting the catalytic mechanism of protein-tyrosine phosphatases. Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1624-7. PMID: 8127855.
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    215. Brayton KA, Chen Z, Zhou G, Nagy PL, Gavalas A, Trent JM, Deaven LL, Dixon JE, Zalkin H. Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed. J Biol Chem. 1994 Feb 18; 269(7):5313-21. PMID: 8106516.
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    216. Kwak SP, Hakes DJ, Martell KJ, Dixon JE. Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene. J Biol Chem. 1994 Feb 04; 269(5):3596-604. PMID: 8106404.
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    217. Mourey RJ, Dixon JE. Protein tyrosine phosphatases: characterization of extracellular and intracellular domains. Curr Opin Genet Dev. 1994 Feb; 4(1):31-9. PMID: 8193537.
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    218. Zhang ZY, Dixon JE. Protein tyrosine phosphatases: mechanism of catalysis and substrate specificity. Adv Enzymol Relat Areas Mol Biol. 1994; 68:1-36. PMID: 8154323.
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    219. Dixon JE, Sadowski PD. Resolution of synthetic chi structures by the FLP site-specific recombinase. J Mol Biol. 1993 Dec 05; 234(3):522-33. PMID: 8254657.
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    220. Guan KL, Dixon JE. Bacterial and viral protein tyrosine phosphatases. Semin Cell Biol. 1993 Dec; 4(6):389-96. PMID: 8305677.
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    221. Rufaut NW, Brennan SO, Hakes DJ, Dixon JE, Birch NP. Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line. J Biol Chem. 1993 Sep 25; 268(27):20291-8. PMID: 8376387.
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    222. Stone RL, Zalkin H, Dixon JE. Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase. J Biol Chem. 1993 Sep 15; 268(26):19710-6. PMID: 8366112.
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    223. Zhang ZY, Dixon JE. Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Biochemistry. 1993 Sep 14; 32(36):9340-5. PMID: 8369304.
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    224. Zhuo S, Clemens JC, Hakes DJ, Barford D, Dixon JE. Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase. J Biol Chem. 1993 Aug 25; 268(24):17754-61. PMID: 8394350.
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    225. Park YS, Sweitzer TD, Dixon JE, Kent C. Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis. J Biol Chem. 1993 Aug 05; 268(22):16648-54. PMID: 8393871.
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    226. Walton KM, Martell KJ, Kwak SP, Dixon JE, Largent BL. A novel receptor-type protein tyrosine phosphatase is expressed during neurogenesis in the olfactory neuroepithelium. Neuron. 1993 Aug; 11(2):387-400. PMID: 8352946.
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    227. Lin HL, Day NC, Ueda Y, Martin DK, Dixon JE, Seidah NG, Akil H. Tissue-specific and substrate-specific endoproteolytic cleavage of monkey pro-opiomelanocortin in heterologous endocrine cells: processing at Lys-Lys dibasic pairs. Neuroendocrinology. 1993 Jul; 58(1):94-105. PMID: 7903430.
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    228. Zhang ZY, Maclean D, Thieme-Sefler AM, Roeske RW, Dixon JE. A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides. Anal Biochem. 1993 May 15; 211(1):7-15. PMID: 7686722.
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    229. Zhang ZY, Thieme-Sefler AM, Maclean D, McNamara DJ, Dobrusin EM, Sawyer TK, Dixon JE. Substrate specificity of the protein tyrosine phosphatases. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4446-50. PMID: 7685104.
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    230. Hakes DJ, Martell KJ, Zhao WG, Massung RF, Esposito JJ, Dixon JE. A protein phosphatase related to the vaccinia virus VH1 is encoded in the genomes of several orthopoxviruses and a baculovirus. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):4017-21. PMID: 8387208.
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    231. McLaughlin S, Dixon JE. Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J Biol Chem. 1993 Apr 05; 268(10):6839-42. PMID: 8463208.
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    232. David M, Romero G, Zhang ZY, Dixon JE, Larner AC. In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase. J Biol Chem. 1993 Mar 25; 268(9):6593-9. PMID: 8454630.
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    233. Williams JS, Dixon JE, Andrisani OM. Binding constant determination studies utilizing recombinant delta CREB protein. DNA Cell Biol. 1993 Mar; 12(2):183-90. PMID: 8471166.
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    234. Kulpa J, Dixon JE, Pan G, Sadowski PD. Mutations of the FLP recombinase gene that cause a deficiency in DNA bending and strand cleavage. J Biol Chem. 1993 Jan 15; 268(2):1101-8. PMID: 8419317.
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    235. Walton KM, Dixon JE. Protein tyrosine phosphatases. Annu Rev Biochem. 1993; 62:101-20. PMID: 8352585.
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    236. Guan K, Hakes D, Dixon JE, Park HD, Cooper TG. The yeast open reading frame encoding a dual specificity phosphatase. Trends Biochem Sci. 1993 Jan; 18(1):6. PMID: 8438236.
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    237. Guan K, Hakes DJ, Wang Y, Park HD, Cooper TG, Dixon JE. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12175-9. PMID: 1334559.
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    238. Millar JB, Russell P, Dixon JE, Guan KL. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. EMBO J. 1992 Dec; 11(13):4943-52. PMID: 1464319.
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    239. Bliska JB, Clemens JC, Dixon JE, Falkow S. The Yersinia tyrosine phosphatase: specificity of a bacterial virulence determinant for phosphoproteins in the J774A.1 macrophage. J Exp Med. 1992 Dec 01; 176(6):1625-30. PMID: 1281213.
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    240. Zhang ZY, Clemens JC, Schubert HL, Stuckey JA, Fischer MW, Hume DM, Saper MA, Dixon JE. Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase. J Biol Chem. 1992 Nov 25; 267(33):23759-66. PMID: 1429715.
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    241. Colbran JL, Roach PJ, Fiol CJ, Dixon JE, Andrisani OM, Corbin JD. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov; 70(10-11):1277-82. PMID: 1338414.
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    242. Wang CC, Badylak JA, Lux SE, Moriyama R, Dixon JE, Low PS. Expression, purification, and characterization of the functional dimeric cytoplasmic domain of human erythrocyte band 3 in Escherichia coli. Protein Sci. 1992 Sep; 1(9):1206-14. PMID: 1304397.
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    243. Pot DA, Dixon JE. A thousand and two protein tyrosine phosphatases. Biochim Biophys Acta. 1992 Jul 22; 1136(1):35-43. PMID: 1643113.
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    244. Powell SM, Zalkin H, Dixon JE. Cloning and characterization of the cDNA encoding human adenylosuccinate synthetase. FEBS Lett. 1992 May 25; 303(1):4-10. PMID: 1592113.
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    245. Guan K, Deschenes RJ, Dixon JE. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. J Biol Chem. 1992 May 15; 267(14):10024-30. PMID: 1577774.
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    246. Hakes DJ, Dixon JE. New vectors for high level expression of recombinant proteins in bacteria. Anal Biochem. 1992 May 01; 202(2):293-8. PMID: 1519755.
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    247. Steczko J, Donoho GP, Clemens JC, Dixon JE, Axelrod B. Conserved histidine residues in soybean lipoxygenase: functional consequences of their replacement. Biochemistry. 1992 Apr 28; 31(16):4053-7. PMID: 1567851.
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    248. Zhou G, Broyles SS, Dixon JE, Zalkin H. Avian glutamine phosphoribosylpyrophosphate amidotransferase propeptide processing and activity are dependent upon essential cysteine residues. J Biol Chem. 1992 Apr 15; 267(11):7936-42. PMID: 1560022.
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    249. Woodford-Thomas TA, Rhodes JD, Dixon JE. Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. J Cell Biol. 1992 Apr; 117(2):401-14. PMID: 1373143.
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    250. Stone RL, Aimi J, Barshop BA, Jaeken J, Van den Berghe G, Zalkin H, Dixon JE. A mutation in adenylosuccinate lyase associated with mental retardation and autistic features. Nat Genet. 1992 Apr; 1(1):59-63. PMID: 1302001.
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    251. Pot DA, Dixon JE. Active site labeling of a receptor-like protein tyrosine phosphatase. J Biol Chem. 1992 Jan 05; 267(1):140-3. PMID: 1730581.
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    252. Hakes DJ, Birch NP, Mezey A, Dixon JE. Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats. Endocrinology. 1991 Dec; 129(6):3053-63. PMID: 1954888.
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    253. Clemens JC, Guan K, Bliska JB, Falkow S, Dixon JE. Microbial pathogenesis and tyrosine dephosphorylation: surprising 'bedfellows'. Mol Microbiol. 1991 Nov; 5(11):2617-20. PMID: 1723471.
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    254. Pot DA, Woodford TA, Remboutsika E, Haun RS, Dixon JE. Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase. J Biol Chem. 1991 Oct 15; 266(29):19688-96. PMID: 1918076.
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    255. Ni L, Guan K, Zalkin H, Dixon JE. De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase. Gene. 1991 Oct 15; 106(2):197-205. PMID: 1937050.
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    256. Guan KL, Dixon JE. Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. J Biol Chem. 1991 Sep 15; 266(26):17026-30. PMID: 1654322.
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    257. Jung YK, Kunczt CJ, Pearson RK, Dixon JE, Fricker LD. Structural characterization of the rat carboxypeptidase-E gene. Mol Endocrinol. 1991 Sep; 5(9):1257-68. PMID: 1770952.
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    258. Andres DA, Rhodes JD, Meisel RL, Dixon JE. Characterization of the carboxyl-terminal sequences responsible for protein retention in the endoplasmic reticulum. J Biol Chem. 1991 Aug 05; 266(22):14277-82. PMID: 1650354.
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    259. Guan KL, Deschenes RJ, Qiu H, Dixon JE. Cloning and expression of a yeast protein tyrosine phosphatase. J Biol Chem. 1991 Jul 15; 266(20):12964-70. PMID: 1649172.
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    260. Steczko J, Donoho GA, Dixon JE, Sugimoto T, Axelrod B. Effect of ethanol and low-temperature culture on expression of soybean lipoxygenase L-1 in Escherichia coli. Protein Expr Purif. 1991 Apr-Jun; 2(2-3):221-7. PMID: 1821792.
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    261. Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28; 350(6316):359-62. PMID: 1848923.
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    262. Bliska JB, Guan KL, Dixon JE, Falkow S. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1187-91. PMID: 1705028.
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    263. Guan KL, Dixon JE. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem. 1991 Feb 01; 192(2):262-7. PMID: 1852137.
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    264. Zhou GC, Dixon JE, Zalkin H. Cloning and expression of avian glutamine phosphoribosylpyrophosphate amidotransferase. Conservation of a bacterial propeptide sequence supports a role for posttranslational processing. J Biol Chem. 1990 Dec 05; 265(34):21152-9. PMID: 2123487.
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    265. Aimi J, Qiu H, Williams J, Zalkin H, Dixon JE. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli. Nucleic Acids Res. 1990 Nov 25; 18(22):6665-72. PMID: 2147474.
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    266. Haun RS, Dixon JE. A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene. J Biol Chem. 1990 Sep 15; 265(26):15455-63. PMID: 2118525.
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    267. Dixon JE, Zhu A, Andrisani O. Efforts directed at understanding cell-specific somatostatin gene expression. Metabolism. 1990 Sep; 39(9 Suppl 2):17-9. PMID: 1976211.
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    268. Guan KL, Dixon JE. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 1990 Aug 03; 249(4968):553-6. PMID: 2166336.
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    269. Aimi J, Badylak J, Williams J, Chen ZD, Zalkin H, Dixon JE. Cloning of a cDNA encoding adenylosuccinate lyase by functional complementation in Escherichia coli. J Biol Chem. 1990 Jun 05; 265(16):9011-4. PMID: 2111814.
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    270. Andres DA, Dickerson IM, Dixon JE. Variants of the carboxyl-terminal KDEL sequence direct intracellular retention. J Biol Chem. 1990 Apr 15; 265(11):5952-5. PMID: 2318841.
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    271. Chen ZD, Dixon JE, Zalkin H. Cloning of a chicken liver cDNA encoding 5-aminoimidazole ribonucleotide carboxylase and 5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase by functional complementation of Escherichia coli pur mutants. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3097-101. PMID: 1691501.
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    272. Andrisani O, Dixon JE. Identification and purification of a novel 120-kDa protein that recognizes the cAMP-responsive element. J Biol Chem. 1990 Feb 25; 265(6):3212-8. PMID: 2137455.
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    273. Dickerson IM, Dixon JE, Mains RE. Biosynthesis and posttranslational processing of site-directed endoproteolytic cleavage mutants of pro-neuropeptide Y in mouse pituitary cells. J Biol Chem. 1990 Feb 15; 265(5):2462-9. PMID: 2303410.
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    274. Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1501-5. PMID: 2154749.
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    275. Dixon JE, Kintner CR. Cellular contacts required for neural induction in Xenopus embryos: evidence for two signals. Development. 1989 Aug; 106(4):749-57. PMID: 2485245.
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    276. Zhu Z, Andrisani OM, Pot DA, Dixon JE. Purification and characterization of a 43-kDa transcription factor required for rat somatostatin gene expression. J Biol Chem. 1989 Apr 15; 264(11):6550-6. PMID: 2564850.
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    277. Rodríguez C, Brayton KA, Brownstein M, Dixon JE. Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor. J Biol Chem. 1989 Apr 05; 264(10):5988-95. PMID: 2784437.
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    278. Andrews PC, Dixon JE. Application of fast atom bombardment mass spectrometry to posttranslational modifications of neuropeptides. Methods Enzymol. 1989; 168:72-103. PMID: 2566895.
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    279. Crabb DW, Minth CD, Dixon JE. Assaying the reporter gene chloramphenicol acetyltransferase. Methods Enzymol. 1989; 168:690-701. PMID: 2725317.
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    280. Glembotski CC, Dixon JE, Gibson TR. Secretion of atrial natriuretic factor-(1-98) by primary cardiac myocytes. J Biol Chem. 1988 Nov 05; 263(31):16073-81. PMID: 2972704.
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    281. Nichols R, Dixon JE. Rapid identification of clones using the same degenerate oligonucleotide mixture for both screening and sequencing. Anal Biochem. 1988 Apr; 170(1):110-5. PMID: 3389502.
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    282. Andrews PC, Nichols R, Dixon JE. Post-translational processing of preprosomatostatin-II examined using fast atom bombardment mass spectrometry. J Biol Chem. 1987 Sep 15; 262(26):12692-9. PMID: 2887572.
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    283. Andrews PC, Dixon JE. Isolation of products and intermediates of pancreatic prosomatostatin processing: use of fast atom bombardment mass spectrometry as an aid in analysis of prohormone processing. Biochemistry. 1987 Jul 28; 26(15):4853-61. PMID: 2889466.
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    284. Crabb DW, Dixon JE. A method for increasing the sensitivity of chloramphenicol acetyltransferase assays in extracts of transfected cultured cells. Anal Biochem. 1987 May 15; 163(1):88-92. PMID: 3475989.
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    285. Andrews PC, Dixon JE. A procedure for in situ alkylation of cystine residues on glass fiber prior to protein microsequence analysis. Anal Biochem. 1987 Mar; 161(2):524-8. PMID: 2883913.
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    286. Noe BD, Andrews PC, Dixon JE, Spiess J. Cotranslational and posttranslational proteolytic processing of preprosomatostatin-I in intact islet tissue. J Cell Biol. 1986 Oct; 103(4):1205-11. PMID: 2876999.
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    287. Yazdanparast R, Andrews P, Smith DL, Dixon JE. A new approach for detection and assignment of disulfide bonds in peptides. Anal Biochem. 1986 Mar; 153(2):348-53. PMID: 3706715.
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    288. Dixon JE, Andrews PC. Somatostatins of the channel catfish. Adv Exp Med Biol. 1985; 188:19-29. PMID: 2863931.
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    289. Morin JE, Dixon JE. Thiol: protein disulfide exchange enzymes. Methods Enzymol. 1985; 113:541-7. PMID: 4088073.
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    290. Dixon JE, Woodford TA. Rat pituitary N alpha-acetyltransferase. Methods Enzymol. 1984; 106:170-9. PMID: 6092829.
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    291. Andrews PC, Hines CM, Dixon JE. Characterization of proline endopeptidase from rat brain. Biochemistry. 1980 Nov 25; 19(24):5494-500. PMID: 6779865.
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    292. Taylor WL, Andrews PC, Henrikson CK, Dixon JE. New fluorogenic substrates for a rat brain proline endopeptidase. Anal Biochem. 1980 Jun; 105(1):58-64. PMID: 7004269.
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    293. Woodford TA, Dixon JE. The Nalpha-acetylation of corticotropin and fragments of corticotropin by a rat pituitary Nalpha-acetyltransferase. J Biol Chem. 1979 Jun 25; 254(12):4993-9. PMID: 221456.
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    294. Venter JC, Venter BR, Dixon JE, Kaplan NO. A possible role for glass bead immobilized enzymes as therapeutic agents (immobilized uricase as enzyme therapy for hyperuricemia). Biochem Med. 1975 Jan; 12(1):79-91. PMID: 806289.
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    295. Kaplan NO, Everse J, Dixon JE, Stolzenbach FE, Lee CY, Lee CL, Taylor SS, Mosbach K. Purification and separation of pyridine nucleotide-linked dehydrogenases by affinity chromatography techniques. Proc Natl Acad Sci U S A. 1974 Sep; 71(9):3450-4. PMID: 4372619.
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    296. Venter JC, Dixon JE. Production of glass bead-immobilized catecholamines. Methods Enzymol. 1974; 38:180-6. PMID: 4453191.
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    297. Dixon JE, Bruice TC. Comparison of the rate constants for general base catalyzed prototropy and racemization of the aldimine species formed from 3-hydroxypyridine-4-carboxaldehyde and alanine. Biochemistry. 1973 Nov 06; 12(23):4762-6. PMID: 4773854.
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    298. Widmer F, Dixon JE, Kaplan NO. An apparatus for the determination of kinetic parameters associated with immobilized enzymes. Anal Biochem. 1973 Sep; 55(1):282-7. PMID: 4753153.
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    299. Venter JC, Ross J, Dixon JE, Mayer SE, Kaplan NO. Immobilized catecholamine and cocaine effects on contractility of cardiac muscle. Proc Natl Acad Sci U S A. 1973 Apr; 70(4):1214-7. PMID: 4515619.
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    300. Venter JC, Dixon JE, Maroko PR, Kaplan NO. Biologically active catecholamines covalentyly bound to glass beads. Proc Natl Acad Sci U S A. 1972 May; 69(5):1141-5. PMID: 4338583.
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