Lars Bode

Title(s)Professor In Residence, Pediatrics
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Awards and Honors
    International Society for Research in Human Milk and Lactation (ISRHML)2016President
    International Society for Research in Human Milk and Lactation (ISRHML)2014President-Elect
    International Society for Research in Human Milk and Lactation (ISRHML)2012Ehrlich-Koldovsky Young Investigator Award for Research in Human Milk and Lactation
    American Society for Nutrition (ASN)2013Norman Kretchmer Memorial Award in Nutrition and Development
    American Society for Nutrition (ASN)2014Bio-Serv Award in Experimental Animal Nutrition

    Collapse Overview 
    Collapse Overview
    Human Milk Oligosaccharides (HMO) are the third most abundant component of human breast milk. We are just now beginning to understand how these complex sugars benefit the breast-fed infant (Bode 2006, Bode 2009, Bode 2012).

    The goal of our research is to answer two very fundamental questions regarding HMO:

    How are HMO synthesized in the mother's lactating mammary gland?

    How do HMO benefit the breast-fed infant and potentially also the breast-feeding mother?

    Our lab uses a multidisciplinary collaborative approach that combines preclinical studies and human cohort studies with the goal to identify structure-function relationships in a variety of clinical contexts related to maternal and infant health.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Exploring human milk oligosaccharides and malaria risk in breastfed infants
    NIH R21AI149452Aug 1, 2020 - Jul 31, 2022
    Role: Principal Investigator
    Exploring Associations between Human Milk Oligosaccharides and Growth, Body Composition and Obesity Risk in Infancy and Early Childhood
    NIH R21HD088953Aug 4, 2017 - Jul 31, 2020
    Role: Principal Investigator
    Exploring The Impact of Human Milk Oligosaccharides in Atherosclerosis
    NIH R21HD089067Aug 1, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    Disialyl oligosaccharides as Necrotizing Enterocolitis therapeutics
    NIH R43HD087077Sep 25, 2015 - Sep 30, 2016
    Role: Principal Investigator
    Exploring Oligosaccharide Synthesis in Human Mammary Gland Epithelial Cells
    NIH R21HD080682Feb 23, 2015 - Jan 31, 2017
    Role: Principal Investigator
    Selective Inhibitors of Plasmodium Falciparum G6PD as Novel Antimalarials
    NIH R01AI104916Aug 15, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Screening for Human Milk Oligosaccharides that Protect Infants from HIV Infection
    NIH R03HD059717Sep 1, 2010 - Aug 31, 2011
    Role: Principal Investigator
    Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing Enterocolitis
    NIH R00DK078668Sep 1, 2009 - Jun 30, 2013
    Role: Principal Investigator
    Identification of G6PD inhibitors for the development of novel antimalarial drugs
    NIH R21AI082434Aug 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Fusing Glycobiology and Nutritional Sciences to Prevent Necrotizing Enterocolitis
    NIH K99DK078668Apr 1, 2008 - Aug 31, 2009
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374.
      View in: PubMed   Mentions:    Fields:    
    2. Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants. Gut Microbes. 2020 11 09; 12(1):1813534. Jones RB, Berger PK, Plows JF, Alderete TL, Millstein J, Fogel J, Iablokov SN, Rodionov DA, Osterman AL, Bode L, Goran MI. PMID: 32887539.
      View in: PubMed   Mentions: 3     Fields:    
    3. Evaluation for SARS-CoV-2 in Breast Milk From 18 Infected Women. JAMA. 2020 10 06; 324(13):1347-1348. Chambers C, Krogstad P, Bertrand K, Contreras D, Tobin NH, Bode L, Aldrovandi G. PMID: 32822495.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCellsPHPublic Health
    4. Distance, diffusion and the role of social media in a time of COVID contagion. Matern Child Nutr. 2020 10; 16(4):e13025. Moukarzel S, Del Fresno M, Bode L, Daly AJ. PMID: 32343487.
      View in: PubMed   Mentions: 3     Fields:    
    5. Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring. Nat Metab. 2020 08; 2(8):678-687. Harris JE, Pinckard KM, Wright KR, Baer LA, Arts PJ, Abay E, Shettigar VK, Lehnig AC, Robertson B, Madaris K, Canova TJ, Sims C, Goodyear LJ, Andres A, Ziolo MT, Bode L, Stanford KI. PMID: 32694823.
      View in: PubMed   Mentions:
    6. Evaluation of SARS-CoV-2 in Breastmilk from 18 Infected Women. medRxiv. 2020 Jun 16. Chambers CD, Krogstad P, Bertrand K, Contreras D, Tobin NH, Bode L, Aldrovandi GM. PMID: 32587991.
      View in: PubMed   Mentions:
    7. Human Milk Oligosaccharides: Structure and Functions. Nestle Nutr Inst Workshop Ser. 2020; 94:115-123. Bode L. PMID: 32160614.
      View in: PubMed   Mentions: 5     Fields:    
    8. Understanding the mother-breastmilk-infant "triad". Science. 2020 03 06; 367(6482):1070-1072. Bode L, Raman AS, Murch SH, Rollins NC, Gordon JI. PMID: 32139527.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    9. Through Thick and Thin: The In Vitro Effects of Thickeners on Infant Feed Viscosity. J Pediatr Gastroenterol Nutr. 2019 11; 69(5):e122-e128. Koo JK, Narvasa A, Bode L, Kim JH. PMID: 31449171.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Development of a biochemical marker to detect current breast milk intake. Matern Child Nutr. 2020 01; 16(1):e12859. Addison R, Hill L, Bode L, Robertson B, Choudhury B, Young D, Wright C, Relton C, Garcia AL, Tappin DM. PMID: 31216094.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Welcome and Opening Remarks. Breastfeed Med. 2019 04; 14(S1):S2. Bode L, Rhine WD. PMID: 30985204.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Human Milk Oligosaccharides in the Prevention of Necrotizing Enterocolitis: A Journey From in vitro and in vivo Models to Mother-Infant Cohort Studies. Front Pediatr. 2018; 6:385. Bode L. PMID: 30564564.
      View in: PubMed   Mentions:
    13. A case study on breastfeeding education in Lebanon's public medical school: exploring the potential role of social networks in medical education. Med Educ Online. 2018 Dec; 23(1):1527629. Moukarzel S, Mamas C, Warstadt MF, Bode L, Farhat A, Abi Abboud A, Daly AJ. PMID: 30300105.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Infants Are Exposed to Human Milk Oligosaccharides Already in utero. Front Pediatr. 2018; 6:270. Wise A, Robertson B, Choudhury B, Rautava S, Isolauri E, Salminen S, Bode L. PMID: 30333965.
      View in: PubMed   Mentions:
    15. Human Milk Oligosaccharides at the Interface of Maternal-Infant Health. Breastfeed Med. 2018 04; 13(S1):S7-S8. Bode L. PMID: 29624421.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Human milk oligosaccharide composition predicts risk of necrotising enterocolitis in preterm infants. Gut. 2018 06; 67(6):1064-1070. Autran CA, Kellman BP, Kim JH, Asztalos E, Blood AB, Spence ECH, Patel AL, Hou J, Lewis NE, Bode L. PMID: 28381523.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCTClinical Trials
    17. What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically. Am J Clin Nutr. 2017 05; 105(5):1086-1100. McGuire MK, Meehan CL, McGuire MA, Williams JE, Foster J, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Kvist LJ, Otoo GE, Brooker SL, Price WJ, Shafii B, Placek C, Lackey KA, Robertson B, Manzano S, Ruíz L, Rodríguez JM, Pareja RG, Bode L. PMID: 28356278.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    18. Human Milk Oligosaccharides Influence Intestinal Epithelial Cell Maturation In Vitro. J Pediatr Gastroenterol Nutr. 2017 02; 64(2):296-301. Holscher HD, Bode L, Tappenden KA. PMID: 28114245.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. Human Milk Oligosaccharides and the Preterm Infant: A Journey in Sickness and in Health. Clin Perinatol. 2017 03; 44(1):193-207. Moukarzel S, Bode L. PMID: 28159206.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    20. Overcoming the limited availability of human milk oligosaccharides: challenges and opportunities for research and application. Nutr Rev. 2016 10; 74(10):635-44. Bode L, Contractor N, Barile D, Pohl N, Prudden AR, Boons GJ, Jin YS, Jennewein S. PMID: 27634978.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    21. Maternal HIV infection influences the microbiome of HIV-uninfected infants. Sci Transl Med. 2016 07 27; 8(349):349ra100. Bender JM, Li F, Martelly S, Byrt E, Rouzier V, Leo M, Tobin N, Pannaraj PS, Adisetiyo H, Rollie A, Santiskulvong C, Wang S, Autran C, Bode L, Fitzgerald D, Kuhn L, Aldrovandi GM. PMID: 27464748.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    22. Sialylated galacto-oligosaccharides and 2'-fucosyllactose reduce necrotising enterocolitis in neonatal rats. Br J Nutr. 2016 07; 116(2):294-9. Autran CA, Schoterman MH, Jantscher-Krenn E, Kamerling JP, Bode L. PMID: 27212112.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    23. Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life. Am J Clin Nutr. 2015 Dec; 102(6):1381-8. Alderete TL, Autran C, Brekke BE, Knight R, Bode L, Goran MI, Fields DA. PMID: 26511224.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    24. The functional biology of human milk oligosaccharides. Early Hum Dev. 2015 Nov; 91(11):619-22. Bode L. PMID: 26375354.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    25. Glycan-dependent viral infection in infants and the role of human milk oligosaccharides. Curr Opin Virol. 2014 Aug; 7:101-7. Etzold S, Bode L. PMID: 25047751.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    26. Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis. Angew Chem Int Ed Engl. 2014 Jun 23; 53(26):6687-91. Yu H, Lau K, Thon V, Autran CA, Jantscher-Krenn E, Xue M, Li Y, Sugiarto G, Qu J, Mu S, Ding L, Bode L, Chen X. PMID: 24848971.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    27. Human milk oligosaccharides protect against enteropathogenic Escherichia coli attachment in vitro and EPEC colonization in suckling mice. J Pediatr Gastroenterol Nutr. 2014 Feb; 58(2):165-8. Manthey CF, Autran CA, Eckmann L, Bode L. PMID: 24048169.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    28. Human milk galectin-3 binding protein and breast-feeding-associated HIV transmission. Pediatr Infect Dis J. 2013 Dec; 32(12):e473-5. Chan CS, Kim HY, Autran C, Kim JH, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM, Kuhn L, Bode L. PMID: 23899964.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. Human milk oligosaccharide composition differs between donor milk and mother's own milk in the NICU. J Hum Lact. 2014 Feb; 30(1):54-61. Marx C, Bridge R, Wolf AK, Rich W, Kim JH, Bode L. PMID: 24282194.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    30. Human milk oligosaccharides are differentially metabolised in neonatal rats. Br J Nutr. 2013 Aug; 110(4):640-50. Jantscher-Krenn E, Marx C, Bode L. PMID: 23312292.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    31. Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors. J Biomol Screen. 2013 Mar; 18(3):286-97. Preuss J, Richardson AD, Pinkerton A, Hedrick M, Sergienko E, Rahlfs S, Becker K, Bode L. PMID: 23023104.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    32. Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding. Am J Clin Nutr. 2012 Oct; 96(4):831-9. Bode L, Kuhn L, Kim HY, Hsiao L, Nissan C, Sinkala M, Kankasa C, Mwiya M, Thea DM, Aldrovandi GM. PMID: 22894939.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    33. Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro. J Med Chem. 2012 Aug 23; 55(16):7262-72. Preuss J, Maloney P, Peddibhotla S, Hedrick MP, Hershberger P, Gosalia P, Milewski M, Li YL, Sugarman E, Hood B, Suyama E, Nguyen K, Vasile S, Sergienko E, Mangravita-Novo A, Vicchiarelli M, McAnally D, Smith LH, Roth GP, Diwan J, Chung TD, Jortzik E, Rahlfs S, Becker K, Pinkerton AB, Bode L. PMID: 22813531.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    34. Structure-function relationships of human milk oligosaccharides. Adv Nutr. 2012 May 01; 3(3):383S-91S. Bode L, Jantscher-Krenn E. PMID: 22585916.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    35. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012 Sep; 22(9):1147-62. Bode L. PMID: 22513036.
      View in: PubMed   Mentions: 333     Fields:    Translation:HumansAnimals
    36. High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase. J Biomol Screen. 2012 Jul; 17(6):738-51. Preuss J, Hedrick M, Sergienko E, Pinkerton A, Mangravita-Novo A, Smith L, Marx C, Fischer E, Jortzik E, Rahlfs S, Becker K, Bode L. PMID: 22496096.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. Br J Nutr. 2012 Nov 28; 108(10):1839-46. Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin FD, Bode L. PMID: 22264879.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    38. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2012 Oct; 61(10):1417-25. Jantscher-Krenn E, Zherebtsov M, Nissan C, Goth K, Guner YS, Naidu N, Choudhury B, Grishin AV, Ford HR, Bode L. PMID: 22138535.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimals
    39. Human milk oligosaccharides: prebiotics and beyond. Nutr Rev. 2009 Nov; 67 Suppl 2:S183-91. Bode L. PMID: 19906222.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    40. Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN). Br J Nutr. 2009 Feb; 101(4):482-6. Hong P, Ninonuevo MR, Lee B, Lebrilla C, Bode L. PMID: 19230080.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells