Loading...

Michael Karin

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Phone858-534-0872
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH/NIDDK R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH/NCI R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH/NIAAA U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH/NCI R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH/NIAAA U01AA022614Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH/NCI R01CA163798Jul 16, 2012 - Apr 30, 2017
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH/NCI R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH/NCI R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH/NCI R01CA127923Apr 13, 2007 - Feb 28, 2018
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH/NCI R01CA118165Dec 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH/NIAID R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH/NIAID R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH/NCI R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH/NIAID R01AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH/NCI R01CA076188Feb 15, 1998 - Jul 31, 2007
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH/NIEHS R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH/NHLBI R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH/NIDDK R01DK038527Sep 1, 1987 - Apr 30, 1999
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH/NHLBI P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Todoric J, Karin M. The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 May 13; 35(5):714-720. PMID: 31085174.
      View in: PubMed
    2. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 Jun 04; 29(6):1350-1362.e7. PMID: 30982734.
      View in: PubMed
    3. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. PMID: 30973461.
      View in: PubMed
    4. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 Dec; 15(12):785. PMID: 29785003.
      View in: PubMed
    5. Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 Jan 08; 29(1):18-26. PMID: 30449681.
      View in: PubMed
    6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. PMID: 30445007.
      View in: PubMed
    7. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. PMID: 30287485.
      View in: PubMed
    8. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 Sep 20; 175(1):133-145.e15. PMID: 30220454.
      View in: PubMed
    9. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. PMID: 30209212.
      View in: PubMed
    10. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. PMID: 29973714.
      View in: PubMed
    11. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. PMID: 30046112.
      View in: PubMed
    12. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 Jul; 15(7):397-411. PMID: 29748586.
      View in: PubMed
    13. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 Jun 11; 33(6):1061-1077.e6. PMID: 29894692.
      View in: PubMed
    14. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 Jul; 69(1):79-88. PMID: 29505847.
      View in: PubMed
    15. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541. PMID: 29362479.
      View in: PubMed
    16. Taniguchi K, Karin M. NF-?B, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 May; 18(5):309-324. PMID: 29379212.
      View in: PubMed
    17. Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. IKKa inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E812-E821. PMID: 29311298.
      View in: PubMed
    18. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. PMID: 29168501.
      View in: PubMed
    19. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. PMID: 29153842.
      View in: PubMed
    20. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. PMID: 29144460.
      View in: PubMed
    21. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1. PLoS One. 2017; 12(8):e0181052. PMID: 28797077.
      View in: PubMed
    22. Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. IKKß inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 2017 10; 60(10):2021-2032. PMID: 28725915.
      View in: PubMed
    23. Afonina IS, Zhong Z, Karin M, Beyaert R. Limiting inflammation-the negative regulation of NF-?B and the NLRP3 inflammasome. Nat Immunol. 2017 Jul 19; 18(8):861-869. PMID: 28722711.
      View in: PubMed
    24. Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7414-7419. PMID: 28652331.
      View in: PubMed
    25. Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 05; 24(5):929-943. PMID: 28387757.
      View in: PubMed
    26. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. PMID: 28167773.
      View in: PubMed
    27. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. PMID: 28130546.
      View in: PubMed
    28. Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat Immunol. 2017 03; 18(3):354-363. PMID: 28114291.
      View in: PubMed
    29. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. Corrigendum: PI3K? is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. PMID: 27974794.
      View in: PubMed
    30. Todoric J, Antonucci L, Karin M. Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prev Res (Phila). 2016 Dec; 9(12):895-905. PMID: 27913448.
      View in: PubMed
    31. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. PMID: 27814504.
      View in: PubMed
    32. Moscat J, Karin M, Diaz-Meco MT. p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 2016 Oct 20; 167(3):606-609. PMID: 27768885.
      View in: PubMed
    33. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 2016 10 10; 30(4):595-609. PMID: 27728806.
      View in: PubMed
    34. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3K? is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. PMID: 27642729.
      View in: PubMed
    35. Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. I?B kinasea/ß control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology. 2016 10; 64(4):1217-31. PMID: 27396433.
      View in: PubMed
    36. Taniguchi K, Yamachika S, He F, Karin M. p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 2016 08; 590(15):2375-97. PMID: 27404485; PMCID: PMC4983218 [Available on 08/06/17].
      View in: PubMed, PubMed Central
    37. Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6. PMID: 27586797.
      View in: PubMed
    38. Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298. PMID: 27419869; PMCID: PMC4947210 [Available on 07/14/17].
      View in: PubMed, PubMed Central
    39. McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS. Neutrophil-Derived IL-1ß Impairs the Efficacy of NF-?B Inhibitors against Lung Cancer. Cell Rep. 2016 06 28; 16(1):120-132. PMID: 27320908.
      View in: PubMed
    40. Lee JH, Cho US, Karin M. Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 2016 06 07; 9(431):re5. PMID: 27273098.
      View in: PubMed
    41. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. PMID: 27211490; PMCID: PMC4907799 [Available on 06/13/17].
      View in: PubMed, PubMed Central
    42. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 05 17; 7:11551. PMID: 27187615.
      View in: PubMed
    43. Shalapour S, Karin M. Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. Cell Metab. 2016 05 10; 23(5):759-61. PMID: 27166937.
      View in: PubMed
    44. Karin M, Dhar D. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis. 2016 06; 37(6):541-6. PMID: 27207669.
      View in: PubMed
    45. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. PMID: 26919428; PMCID: PMC4769378 [Available on 02/25/17].
      View in: PubMed, PubMed Central
    46. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
      View in: PubMed
    47. Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 2016 Jan 21; 529(7586):307-15. PMID: 26791721.
      View in: PubMed
    48. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38a-Dependent Restraint of NF-?B Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76. PMID: 26792803.
      View in: PubMed
    49. Font-Burgada J, Sun B, Karin M. Obesity and Cancer: The Oil that Feeds the Flame. Cell Metab. 2016 Jan 12; 23(1):48-62. PMID: 26771116.
      View in: PubMed
    50. Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5. PMID: 26554006; PMCID: PMC4664371.
      View in: PubMed, PubMed Central
    51. Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun. 2015 Nov 02; 6:8695. PMID: 26522614; PMCID: PMC4659838.
      View in: PubMed, PubMed Central
    52. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6166-74. PMID: 26512112; PMCID: PMC4653219.
      View in: PubMed, PubMed Central
    53. Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44. PMID: 26502405; PMCID: PMC4653079.
      View in: PubMed, PubMed Central
    54. Wang K, Karin M. The IL-23 to IL-17 cascade inflammation-related cancers. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S87-90. PMID: 26457610.
      View in: PubMed
    55. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nat Commun. 2015 Oct 12; 6:8428. PMID: 26455434.
      View in: PubMed
    56. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029. PMID: 26390293; PMCID: PMC4642703.
      View in: PubMed, PubMed Central
    57. Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2016 05 19; 35(20):2634-44. PMID: 26364612; PMCID: PMC4791217.
      View in: PubMed, PubMed Central
    58. Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015 Sep; 125(9):3347-55. PMID: 26325032; PMCID: PMC4588298.
      View in: PubMed, PubMed Central
    59. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631; PMCID: PMC4545590.
      View in: PubMed, PubMed Central
    60. Strasner A, Karin M. Immune Infiltration and Prostate Cancer. Front Oncol. 2015; 5:128. PMID: 26217583; PMCID: PMC4495337.
      View in: PubMed, PubMed Central
    61. Wu X, Karin M. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 Jul; 266(1):161-74. PMID: 26085214.
      View in: PubMed
    62. Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. Dynamic aberrant NF-?B spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev. 2015 Aug; 26(4):389-403. PMID: 26119834; PMCID: PMC4526340.
      View in: PubMed, PubMed Central
    63. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. PMID: 26109050; PMCID: PMC4495398.
      View in: PubMed, PubMed Central
    64. Wang K, Karin M. Tumor-Elicited Inflammation and Colorectal Cancer. Adv Cancer Res. 2015; 128:173-96. PMID: 26216633.
      View in: PubMed
    65. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. PMID: 25924065; PMCID: PMC4501632.
      View in: PubMed, PubMed Central
    66. Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. PMID: 25909884.
      View in: PubMed
    67. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502. PMID: 25819761; PMCID: PMC4377584.
      View in: PubMed, PubMed Central
    68. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
      View in: PubMed, PubMed Central
    69. Shaked H, Guma M, Karin M. Analysis of NF-?B activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. PMID: 25736774.
      View in: PubMed
    70. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63. PMID: 25526314; PMCID: PMC4272447 [Available on 12/18/15].
      View in: PubMed, PubMed Central
    71. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. PMID: 25457612; PMCID: PMC4303546.
      View in: PubMed, PubMed Central
    72. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. PMID: 25404284; PMCID: PMC4260592.
      View in: PubMed, PubMed Central
    73. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015 Feb; 29(2):408-17. PMID: 25366347; PMCID: PMC4314228.
      View in: PubMed, PubMed Central
    74. Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A. Myeloid IKKß promotes antitumor immunity by modulating CCL11 and the innate immune response. Cancer Res. 2014 Dec 15; 74(24):7274-84. PMID: 25336190; PMCID: PMC4349570.
      View in: PubMed, PubMed Central
    75. Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014 Oct 13; 26(4):549-64. PMID: 25314080.
      View in: PubMed
    76. Karin M. Whipping NF-?B to Submission via GADD45 and MKK7. Cancer Cell. 2014 Oct 13; 26(4):447-9. PMID: 25314072.
      View in: PubMed
    77. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. IKKa negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977. PMID: 25266676.
      View in: PubMed
    78. Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. PMID: 25267627; PMCID: PMC4205637.
      View in: PubMed, PubMed Central
    79. Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 03; 33(21):2581-96. PMID: 25260751; PMCID: PMC4282369.
      View in: PubMed, PubMed Central
    80. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. PMID: 26594598.
      View in: PubMed
    81. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770; PMCID: PMC4183333.
      View in: PubMed, PubMed Central
    82. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. PMID: 25132496; PMCID: PMC4165611.
      View in: PubMed, PubMed Central
    83. Fang DF, He K, Wang N, Sang ZH, Qiu X, Xu G, Jian Z, Liang B, Li T, Li HY, Li AL, Zhou T, Gong WL, Yang B, Karin M, Zhang XM, Li WH. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nat Commun. 2014 Jul 29; 5:4513. PMID: 25072696.
      View in: PubMed
    84. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
      View in: PubMed, PubMed Central
    85. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. PMID: 24910242; PMCID: PMC4079758.
      View in: PubMed, PubMed Central
    86. Sun B, Karin M. The therapeutic value of targeting inflammation in gastrointestinal cancers. Trends Pharmacol Sci. 2014 Jul; 35(7):349-57. PMID: 24881011; PMCID: PMC4108072.
      View in: PubMed, PubMed Central
    87. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83. PMID: 24735923; PMCID: PMC3995091.
      View in: PubMed, PubMed Central
    88. Taniguchi K, Karin M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 2014 Feb; 26(1):54-74. PMID: 24552665.
      View in: PubMed
    89. Karin M, Jobin C, Balkwill F. Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med. 2014 Feb; 20(2):126-7. PMID: 24504404; PMCID: PMC4339017.
      View in: PubMed, PubMed Central
    90. Woo JR, Liss MA, Muldong MT, Palazzi K, Strasner A, Ammirante M, Varki N, Shabaik A, Howell S, Kane CJ, Karin M, Jamieson CA. Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014 Jan 30; 12:30. PMID: 24475900; PMCID: PMC3914187.
      View in: PubMed, PubMed Central
    91. Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. Critical role for IL-1ß in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11. PMID: 24469832; PMCID: PMC3926043.
      View in: PubMed, PubMed Central
    92. Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PLoS One. 2014; 9(1):e83391. PMID: 24416163; PMCID: PMC3885413.
      View in: PubMed, PubMed Central
    93. Dhar D, Seki E, Karin M. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7. PMID: 24411937; PMCID: PMC3947913.
      View in: PubMed, PubMed Central
    94. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1090-5. PMID: 24395807; PMCID: PMC3903249.
      View in: PubMed, PubMed Central
    95. Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91. PMID: 24333183; PMCID: PMC3960359.
      View in: PubMed, PubMed Central
    96. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041; PMCID: PMC3839688.
      View in: PubMed, PubMed Central
    97. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. PMID: 24120137; PMCID: PMC4015514.
      View in: PubMed, PubMed Central
    98. Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal. 2013 Oct 01; 6(295):ra87. PMID: 24084649; PMCID: PMC4004444.
      View in: PubMed, PubMed Central
    99. Lee JH, Budanov AV, Karin M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 03; 18(6):792-801. PMID: 24055102; PMCID: PMC3858445.
      View in: PubMed, PubMed Central
    100. Ammirante M, Kuraishy AI, Shalapour S, Strasner A, Ramirez-Sanchez C, Zhang W, Shabaik A, Karin M. An IKKa-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes Dev. 2013 Jul 01; 27(13):1435-40. PMID: 23796898; PMCID: PMC3713424.
      View in: PubMed, PubMed Central
    101. Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1199-209.e4. PMID: 23622129; PMCID: PMC3786712.
      View in: PubMed, PubMed Central
    102. Sun B, Karin M. Inflammation and liver tumorigenesis. Front Med. 2013 Jun; 7(2):242-54. PMID: 23681888.
      View in: PubMed
    103. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIK-IKKa module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59. PMID: 23602409; PMCID: PMC3981467.
      View in: PubMed, PubMed Central
    104. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43. PMID: 23563314.
      View in: PubMed
    105. Simonin Y, Vegna S, Akkari L, Grégoire D, Antoine E, Piette J, Floc'h N, Lassus P, Yu GY, Rosenberg AR, Karin M, Durantel D, Hibner U. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog. 2013 Mar; 9(3):e1003234. PMID: 23555249; PMCID: PMC3605200.
      View in: PubMed, PubMed Central
    106. Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. I kappa B kinase alpha (IKKa) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20; 32(6):816-28. PMID: 23422957; PMCID: PMC3604721.
      View in: PubMed, PubMed Central
    107. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. PMID: 23341606; PMCID: PMC3568328.
      View in: PubMed, PubMed Central
    108. Wang K, Karin M. Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975. PMID: 24516778.
      View in: PubMed
    109. Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24. PMID: 23271722.
      View in: PubMed
    110. Wang K, Grivennikov SI, Karin M. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3. PMID: 23253923.
      View in: PubMed
    111. Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 04; 288(1):598-607. PMID: 23155052.
      View in: PubMed
    112. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. PMID: 23034650; PMCID: PMC3601659.
      View in: PubMed, PubMed Central
    113. Yu GY, He G, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang LH, Karin M. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21. PMID: 22959272; PMCID: PMC3483424.
      View in: PubMed, PubMed Central
    114. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
      View in: PubMed, PubMed Central
    115. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549; PMCID: PMC3397277.
      View in: PubMed, PubMed Central
    116. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. PMID: 22893683; PMCID: PMC3435160.
      View in: PubMed, PubMed Central
    117. Gaba A, Grivennikov SI, Do MV, Stumpo DJ, Blackshear PJ, Karin M. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93. PMID: 22865915; PMCID: PMC3424405.
      View in: PubMed, PubMed Central
    118. Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. The pore-forming toxin ß hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812. PMID: 22829768; PMCID: PMC3400567.
      View in: PubMed, PubMed Central
    119. Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006; PMCID: PMC3523093.
      View in: PubMed, PubMed Central
    120. Font-Burgada J, Seki E, Karin M. CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2. PMID: 22698394; PMCID: PMC4718070.
      View in: PubMed, PubMed Central
    121. Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. IKKa-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77. PMID: 22544702; PMCID: PMC3369682.
      View in: PubMed, PubMed Central
    122. Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. I?B kinase ß (IKKß) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J. 2012 Mar 15; 442(3):723-32. PMID: 22364283.
      View in: PubMed
    123. DiDonato JA, Mercurio F, Karin M. NF-?B and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400. PMID: 22435567.
      View in: PubMed
    124. Aghajan M, Li N, Karin M. Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4. PMID: 22320909; PMCID: PMC3298015.
      View in: PubMed, PubMed Central
    125. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):E177-86. PMID: 22203995; PMCID: PMC3268290.
      View in: PubMed, PubMed Central
    126. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. PMID: 22196886; PMCID: PMC3268914.
      View in: PubMed, PubMed Central
    127. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47. PMID: 22153071; PMCID: PMC3251960.
      View in: PubMed, PubMed Central
    128. Sun B, Karin M. Obesity, inflammation, and liver cancer. J Hepatol. 2012 Mar; 56(3):704-13. PMID: 22120206; PMCID: PMC3889660.
      View in: PubMed, PubMed Central
    129. Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. Cell-selective inhibition of NF-?B signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507. PMID: 22389871; PMCID: PMC3290412.
      View in: PubMed, PubMed Central
    130. Kuraishy A, Karin M, Grivennikov SI. Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77. PMID: 22035839; PMCID: PMC3587290.
      View in: PubMed, PubMed Central
    131. Fujiwara R, Chen S, Karin M, Tukey RH. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. PMID: 21983082; PMCID: PMC3428231.
      View in: PubMed, PubMed Central
    132. Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84. PMID: 21962514; PMCID: PMC3295636.
      View in: PubMed, PubMed Central
    133. Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011 Sep; 134(Pt 9):2722-35. PMID: 21908876.
      View in: PubMed
    134. Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14. PMID: 21815634; PMCID: PMC3174326.
      View in: PubMed, PubMed Central
    135. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. PMID: 21825016; PMCID: PMC3171091.
      View in: PubMed, PubMed Central
    136. Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13710-5. PMID: 21807998; PMCID: PMC3158164.
      View in: PubMed, PubMed Central
    137. Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-?B as the matchmaker. Nat Immunol. 2011 Jul 19; 12(8):715-23. PMID: 21772280.
      View in: PubMed
    138. Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44. PMID: 21683629; PMCID: PMC3889666.
      View in: PubMed, PubMed Central
    139. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 2011 Jun 14; 19(6):740-53. PMID: 21665148.
      View in: PubMed
    140. Häcker H, Tseng PH, Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011 Jun 10; 11(7):457-68. PMID: 21660053.
      View in: PubMed
    141. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. PMID: 21305529.
      View in: PubMed
    142. Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. IKK-ß-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 2011 May; 41(5):1266-77. PMID: 21469085.
      View in: PubMed
    143. Li N, Grivennikov SI, Karin M. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 2011 Apr 12; 19(4):429-31. PMID: 21481782; PMCID: PMC3111086.
      View in: PubMed, PubMed Central
    144. Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. Crystal structure of inhibitor of ?B kinase ß. Nature. 2011 Apr 21; 472(7343):325-30. PMID: 21423167.
      View in: PubMed
    145. Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. Transcriptional regulation of the Th17 immune response by IKK(alpha). J Exp Med. 2011 Apr 11; 208(4):787-96. PMID: 21402739; PMCID: PMC3135338.
      View in: PubMed, PubMed Central
    146. Grivennikov SI, Karin M. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i104-8. PMID: 21339211.
      View in: PubMed
    147. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53. PMID: 21326202; PMCID: PMC3166217.
      View in: PubMed, PubMed Central
    148. Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. IKKß regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318. PMID: 21587235.
      View in: PubMed
    149. Kim S, Karin M. Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011 Jan; 1217:191-206. PMID: 21276007; PMCID: PMC4383094.
      View in: PubMed, PubMed Central
    150. He G, Karin M. NF-?B and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011 Jan; 21(1):159-68. PMID: 21187858; PMCID: PMC3193410.
      View in: PubMed, PubMed Central
    151. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. PMID: 21173249; PMCID: PMC3017162.
      View in: PubMed, PubMed Central
    152. Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. IL-1ß-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKß. Nat Immunol. 2011 Feb; 12(2):144-50. PMID: 21170027; PMCID: PMC3677078.
      View in: PubMed, PubMed Central
    153. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. PMID: 21135226; PMCID: PMC3009768.
      View in: PubMed, PubMed Central
    154. Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S. Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010 Dec 08; 10(12):5088-92. PMID: 21038917.
      View in: PubMed
    155. Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60. PMID: 20956327; PMCID: PMC2973856.
      View in: PubMed, PubMed Central
    156. Budanov AV, Lee JH, Karin M. Stressin' Sestrins take an aging fight. EMBO Mol Med. 2010 Oct; 2(10):388-400. PMID: 20878915; PMCID: PMC3166214.
      View in: PubMed, PubMed Central
    157. Greten FR, Karin M. Peering into the aftermath: JAKi rips STAT3 in cancer. Nat Med. 2010 Oct; 16(10):1085-7. PMID: 20930749.
      View in: PubMed
    158. Napolitano G, Karin M. Sphingolipids: the oil on the TRAFire that promotes inflammation. Sci Signal. 2010 Sep 28; 3(141):pe34. PMID: 20876871.
      View in: PubMed
    159. Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75. PMID: 20841473; PMCID: PMC2948598.
      View in: PubMed, PubMed Central
    160. Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, Lebon P, Rozenberg F, Karin M, Tardieu M, Al-Muhsen S, Jouanguy E, Zhang SY, Abel L, Casanova JL. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010 Sep 24; 33(3):400-11. PMID: 20832341; PMCID: PMC2946444.
      View in: PubMed, PubMed Central
    161. Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27; 39(4):570-82. PMID: 20797629.
      View in: PubMed
    162. Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest. 2010 Jul; 120(7):2563-74. PMID: 20530876; PMCID: PMC2898608.
      View in: PubMed, PubMed Central
    163. Terzic J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology. 2010 Jun; 138(6):2101-2114.e5. PMID: 20420949.
      View in: PubMed
    164. Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. PMID: 20606249; PMCID: PMC2919257.
      View in: PubMed, PubMed Central
    165. Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12. PMID: 20494824; PMCID: PMC2908188.
      View in: PubMed, PubMed Central
    166. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. PMID: 20386472; PMCID: PMC2941912.
      View in: PubMed, PubMed Central
    167. Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010 Aug; 24(8):2596-611. PMID: 20371626.
      View in: PubMed
    168. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010 Mar 19; 140(6):883-99. PMID: 20303878; PMCID: PMC2866629.
      View in: PubMed, PubMed Central
    169. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97. PMID: 20227042; PMCID: PMC2841312.
      View in: PubMed, PubMed Central
    170. Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010 Mar 11; 464(7286):302-5. PMID: 20220849; PMCID: PMC2866639.
      View in: PubMed, PubMed Central
    171. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. PMID: 20203043; PMCID: PMC2866632.
      View in: PubMed, PubMed Central
    172. Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010 Jan 22; 140(2):197-208. PMID: 20141834; PMCID: PMC2836922.
      View in: PubMed, PubMed Central
    173. Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-15. PMID: 20097762; PMCID: PMC2843220.
      View in: PubMed, PubMed Central
    174. Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97. PMID: 20129250; PMCID: PMC2818776.
      View in: PubMed, PubMed Central
    175. Grivennikov SI, Karin M. Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010 Feb; 20(1):65-71. PMID: 20036794; PMCID: PMC2821983.
      View in: PubMed, PubMed Central
    176. Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010 Feb; 21(1):11-9. PMID: 20018552; PMCID: PMC2834864.
      View in: PubMed, PubMed Central
    177. Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J Immunol. 2009 Dec 15; 183(12):7877-89. PMID: 20007573; PMCID: PMC4095798.
      View in: PubMed, PubMed Central
    178. Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 2010 Mar; 138(3):1022-34.e1-10. PMID: 19962981; PMCID: PMC2831162.
      View in: PubMed, PubMed Central
    179. Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology. 2009 Dec; 50(6):1851-60. PMID: 19821485.
      View in: PubMed
    180. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. PMID: 19950258; PMCID: PMC2847793.
      View in: PubMed, PubMed Central
    181. Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan; 11(1):70-5. PMID: 19898473; PMCID: PMC2872790.
      View in: PubMed, PubMed Central
    182. Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a000141. PMID: 20066113; PMCID: PMC2773649.
      View in: PubMed, PubMed Central
    183. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 06; 16(4):295-308. PMID: 19800575; PMCID: PMC4422166.
      View in: PubMed, PubMed Central
    184. Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009 Nov 12; 114(20):4469-76. PMID: 19755673.
      View in: PubMed
    185. Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol. 2009 Sep 15; 183(6):3831-8. PMID: 19710465.
      View in: PubMed
    186. Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009 Aug 19; 4(8):e6695. PMID: 19690611; PMCID: PMC2723911.
      View in: PubMed, PubMed Central
    187. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. PMID: 19541630; PMCID: PMC2722361.
      View in: PubMed, PubMed Central
    188. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. PMID: 19433784; PMCID: PMC2688966.
      View in: PubMed, PubMed Central
    189. Karin M, Gallagher E. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev. 2009 Mar; 228(1):225-40. PMID: 19290931.
      View in: PubMed
    190. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. PMID: 19203587.
      View in: PubMed
    191. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13. PMID: 19185845; PMCID: PMC2667107.
      View in: PubMed, PubMed Central
    192. Koch KS, Maeda S, He G, Karin M, Leffert HL. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54. PMID: 19171122; PMCID: PMC2663043.
      View in: PubMed, PubMed Central
    193. Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009 Jan; 8(1):33-40. PMID: 19116625; PMCID: PMC2729321.
      View in: PubMed, PubMed Central
    194. Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009 Jan 01; 457(7225):102-6. PMID: 19122641; PMCID: PMC2746432.
      View in: PubMed, PubMed Central
    195. Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733. PMID: 19302050.
      View in: PubMed
    196. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20197-202. PMID: 19091944; PMCID: PMC2629300.
      View in: PubMed, PubMed Central
    197. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. PMID: 19001420; PMCID: PMC2613605.
      View in: PubMed, PubMed Central
    198. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec; 9(12):1364-70. PMID: 18997792; PMCID: PMC2671996.
      View in: PubMed, PubMed Central
    199. Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17091-6. PMID: 18957551; PMCID: PMC2579383.
      View in: PubMed, PubMed Central
    200. Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13. PMID: 18922779; PMCID: PMC2567907.
      View in: PubMed, PubMed Central
    201. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008 Oct 03; 135(1):61-73. PMID: 18854155; PMCID: PMC2586330.
      View in: PubMed, PubMed Central
    202. Hou Y, Li F, Karin M, Ostrowski MC. Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35. PMID: 18816823; PMCID: PMC2998709.
      View in: PubMed, PubMed Central
    203. Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain. 2008 Nov; 131(Pt 11):3019-33. PMID: 18819987; PMCID: PMC2577806.
      View in: PubMed, PubMed Central
    204. Descargues P, Sil AK, Karin M. IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J. 2008 Oct 22; 27(20):2639-47. PMID: 18818691.
      View in: PubMed
    205. Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63. PMID: 18815378; PMCID: PMC2567492.
      View in: PubMed, PubMed Central
    206. Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65. PMID: 18691550; PMCID: PMC2707922.
      View in: PubMed, PubMed Central
    207. Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 08; 134(3):451-60. PMID: 18692468; PMCID: PMC2758522.
      View in: PubMed, PubMed Central
    208. Meinzer U, Esmiol-Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, Chareyre F, Niwa-Kawakita M, Alberti C, Sterkers G, Villard C, Lesuffleur T, Peuchmaur M, Karin M, Eckmann L, Giovannini M, Ollendorff V, Wolf-Watz H, Hugot JP. Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One. 2008 Jul 23; 3(7):e2769. PMID: 18648508; PMCID: PMC2447872.
      View in: PubMed, PubMed Central
    209. Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9. PMID: 18633439.
      View in: PubMed
    210. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008 Aug 01; 321(5889):663-8. PMID: 18635759; PMCID: PMC2669719.
      View in: PubMed, PubMed Central
    211. Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008 Oct; 135(4):1311-21. PMID: 18700144.
      View in: PubMed
    212. Bernassola F, Karin M, Ciechanover A, Melino G. The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 2008 Jul 08; 14(1):10-21. PMID: 18598940.
      View in: PubMed
    213. Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008 Jul 01; 68(13):5031-9. PMID: 18593901.
      View in: PubMed
    214. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. PMID: 18511561; PMCID: PMC2409384.
      View in: PubMed, PubMed Central
    215. Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76. PMID: 18490491; PMCID: PMC2413025.
      View in: PubMed, PubMed Central
    216. Naugler WE, Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 2008 Feb; 18(1):19-26. PMID: 18440219; PMCID: PMC2587362.
      View in: PubMed, PubMed Central
    217. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192; PMCID: PMC2669289.
      View in: PubMed, PubMed Central
    218. Karin M. The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 2008 Mar; 18(3):334-42. PMID: 18301380.
      View in: PubMed
    219. Herrlich P, Karin M, Weiss C. Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell. 2008 Feb 15; 29(3):279-90. PMID: 18280234; PMCID: PMC2714880.
      View in: PubMed, PubMed Central
    220. Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2487-92. PMID: 18268325; PMCID: PMC2268163.
      View in: PubMed, PubMed Central
    221. Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008 Mar; 14(3):109-19. PMID: 18261959.
      View in: PubMed
    222. Grivennikov S, Karin M. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell. 2008 Jan; 13(1):7-9. PMID: 18167335.
      View in: PubMed
    223. Temkin V, Karin M. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec; 220:8-21. PMID: 17979836.
      View in: PubMed
    224. Karin M. Rsk Tolls the bell for endocytosis in DCs. Nat Immunol. 2007 Nov; 8(11):1197-9. PMID: 17952046.
      View in: PubMed
    225. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. PMID: 17983584.
      View in: PubMed
    226. Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90. PMID: 17924664.
      View in: PubMed
    227. Cao Y, Luo JL, Karin M. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15852-7. PMID: 17890319; PMCID: PMC2000410.
      View in: PubMed, PubMed Central
    228. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31. PMID: 17803913; PMCID: PMC2134986.
      View in: PubMed, PubMed Central
    229. Van Waes C, Yu M, Nottingham L, Karin M. Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res. 2007 Sep 01; 13(17):4956-9. PMID: 17785544.
      View in: PubMed
    230. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 Jul 06; 317(5834):121-4. PMID: 17615358.
      View in: PubMed
    231. Chen LW, Chen PH, Chang WJ, Wang JS, Karin M, Hsu CM. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Crit Care Med. 2007 May; 35(5):1332-40. PMID: 17414734.
      View in: PubMed
    232. Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May; 117(5):1175-83. PMID: 17476347; PMCID: PMC1857251.
      View in: PubMed, PubMed Central
    233. Mills DM, Bonizzi G, Karin M, Rickert RC. Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6359-64. PMID: 17404218; PMCID: PMC1851084.
      View in: PubMed, PubMed Central
    234. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901. PMID: 17380205; PMCID: PMC1821069.
      View in: PubMed, PubMed Central
    235. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4. PMID: 17377533.
      View in: PubMed
    236. Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007 Mar 29; 446(7135):552-6. PMID: 17322906.
      View in: PubMed
    237. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60. PMID: 17360634; PMCID: PMC1805532.
      View in: PubMed, PubMed Central
    238. Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1913-8. PMID: 17267600; PMCID: PMC1794308.
      View in: PubMed, PubMed Central
    239. Ruocco MG, Karin M. Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 2007; 602:125-34. PMID: 17966397.
      View in: PubMed
    240. Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos. 2007 Mar; 35(3):402-9. PMID: 17151194.
      View in: PubMed
    241. Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007 Jan; 8(1):57-63. PMID: 17143273.
      View in: PubMed
    242. Karin M. Role for IKK2 in muscle: waste not, want not. J Clin Invest. 2006 Nov; 116(11):2866-8. PMID: 17080193; PMCID: PMC1626137.
      View in: PubMed, PubMed Central
    243. Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 01; 177(9):6344-52. PMID: 17056565.
      View in: PubMed
    244. Solinas G, Naugler W, Galimi F, Lee MS, Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16454-9. PMID: 17050683; PMCID: PMC1637603.
      View in: PubMed, PubMed Central
    245. Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17; 2006(357):re13. PMID: 17047224.
      View in: PubMed
    246. Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10. PMID: 16973958; PMCID: PMC1890820.
      View in: PubMed, PubMed Central
    247. Chen F, Lu Y, Castranova V, Li Z, Karin M. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem. 2006 Dec 01; 281(48):37142-9. PMID: 16966325.
      View in: PubMed
    248. Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15. PMID: 16973390.
      View in: PubMed
    249. Labuda T, Christensen JP, Rasmussen S, Bonnesen B, Karin M, Thomsen AR, Odum N. MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. Eur J Immunol. 2006 Aug; 36(8):2076-84. PMID: 16761309.
      View in: PubMed
    250. Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20. PMID: 16818780.
      View in: PubMed
    251. Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 06; 442(7098):39-44. PMID: 16823444.
      View in: PubMed
    252. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6. PMID: 16818881; PMCID: PMC1487172.
      View in: PubMed, PubMed Central
    253. Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10544-51. PMID: 16807293; PMCID: PMC1502270.
      View in: PubMed, PubMed Central
    254. Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun; 45(6):355-61. PMID: 16673382.
      View in: PubMed
    255. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25; 441(7092):431-6. PMID: 16724054.
      View in: PubMed
    256. Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-68. PMID: 16717090.
      View in: PubMed
    257. Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006 Apr; 116(4):1117-26. PMID: 16557301; PMCID: PMC1409741.
      View in: PubMed, PubMed Central
    258. Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35. PMID: 16497591.
      View in: PubMed
    259. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006 Feb 10; 124(3):601-13. PMID: 16469705.
      View in: PubMed
    260. Mahieu T, Park JM, Revets H, Pasche B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2292-7. PMID: 16455798; PMCID: PMC1413734.
      View in: PubMed, PubMed Central
    261. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. PMID: 16455799.
      View in: PubMed
    262. Gallagher E, Gao M, Liu YC, Karin M. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1717-22. PMID: 16446428; PMCID: PMC1413664.
      View in: PubMed, PubMed Central
    263. Karin M. Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lect. 2006-2007; 102:133-51. PMID: 20166567.
      View in: PubMed
    264. Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005 Dec 22; 20(6):891-903. PMID: 16364914.
      View in: PubMed
    265. Liu YC, Penninger J, Karin M. Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 2005 Dec; 5(12):941-52. PMID: 16322747.
      View in: PubMed
    266. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. PMID: 16317067; PMCID: PMC1308936.
      View in: PubMed, PubMed Central
    267. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. PMID: 16306937.
      View in: PubMed
    268. Luo JL, Kamata H, Karin M. The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005 Nov; 25(6):541-50. PMID: 16380818.
      View in: PubMed
    269. Ruocco MG, Karin M. IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis. 2005 Nov; 64 Suppl 4:iv81-5. PMID: 16239395.
      View in: PubMed
    270. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005 Oct; 5(10):749-59. PMID: 16175180.
      View in: PubMed
    271. Luo JL, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest. 2005 Oct; 115(10):2625-32. PMID: 16200195; PMCID: PMC1236696.
      View in: PubMed, PubMed Central
    272. Gao M, Karin M. Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell. 2005 Sep 02; 19(5):581-93. PMID: 16137616.
      View in: PubMed
    273. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29. PMID: 16169504.
      View in: PubMed
    274. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90. PMID: 15989949.
      View in: PubMed
    275. Eckmann L, Karin M. NOD2 and Crohn's disease: loss or gain of function? Immunity. 2005 Jun; 22(6):661-7. PMID: 15963781.
      View in: PubMed
    276. Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Chuang T, Tuthill C, Wan Y, Karin M, Chu WM. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 2005 Jun; 6(6):531-7. PMID: 15905851; PMCID: PMC1369095.
      View in: PubMed, PubMed Central
    277. Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005 May 16; 201(10):1677-87. PMID: 15897281; PMCID: PMC2212920.
      View in: PubMed, PubMed Central
    278. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. PMID: 15858576.
      View in: PubMed
    279. Karin M, Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life. 2005 Apr-May; 57(4-5):283-95. PMID: 16036612.
      View in: PubMed
    280. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11; 120(5):649-61. PMID: 15766528.
      View in: PubMed
    281. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8. PMID: 15692052.
      View in: PubMed
    282. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. PMID: 15685170.
      View in: PubMed
    283. Karin M. Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005; 2(4):386-90; discussion 394-5. PMID: 16267367; PMCID: PMC2713329.
      View in: PubMed, PubMed Central
    284. Karin M. Inflammation and cancer: the long reach of Ras. Nat Med. 2005 Jan; 11(1):20-1. PMID: 15635437.
      View in: PubMed
    285. Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004 Dec 20; 200(12):1647-55. PMID: 15611291; PMCID: PMC2211988.
      View in: PubMed, PubMed Central
    286. Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8. PMID: 15601766; PMCID: PMC539759.
      View in: PubMed, PubMed Central
    287. Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol. 2004 Nov 15; 173(10):6161-8. PMID: 15528353.
      View in: PubMed
    288. Karin M. Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Ann Rheum Dis. 2004 Nov; 63 Suppl 2:ii62-ii64. PMID: 15479874.
      View in: PubMed
    289. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. PMID: 15470505; PMCID: PMC524385.
      View in: PubMed, PubMed Central
    290. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell. 2004 Sep 10; 15(5):713-25. PMID: 15350216.
      View in: PubMed
    291. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 08; 306(5694):271-5. PMID: 15358865.
      View in: PubMed
    292. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004 Sep; 6(3):297-305. PMID: 15380520.
      View in: PubMed
    293. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96. PMID: 15294155.
      View in: PubMed
    294. Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ. CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. J Neuroimmunol. 2004 Aug; 153(1-2):50-63. PMID: 15265663.
      View in: PubMed
    295. Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol. 2004 Jul; 24(13):5914-22. PMID: 15199146; PMCID: PMC480890.
      View in: PubMed, PubMed Central
    296. Li ZW, Rickert RC, Karin M. Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol. 2004 Jul; 41(6-7):701-14. PMID: 15220005.
      View in: PubMed
    297. Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell. 2004 Jun 04; 14(5):571-83. PMID: 15175153.
      View in: PubMed
    298. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004 Jun; 25(6):280-8. PMID: 15145317.
      View in: PubMed
    299. Greten FR, Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004 Apr 08; 206(2):193-9. PMID: 15013524.
      View in: PubMed
    300. Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4. PMID: 15071597.
      View in: PubMed
    301. Amir RE, Haecker H, Karin M, Ciechanover A. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 2004 Apr 01; 23(14):2540-7. PMID: 14676825.
      View in: PubMed
    302. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. PMID: 15037607.
      View in: PubMed
    303. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. PMID: 15029200.
      View in: PubMed
    304. Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 2004 Mar 01; 18(5):584-94. PMID: 15037551; PMCID: PMC374239.
      View in: PubMed, PubMed Central
    305. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7. PMID: 14983030; PMCID: PMC356971.
      View in: PubMed, PubMed Central
    306. Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT. A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb; 6(2):219-27. PMID: 14960276.
      View in: PubMed
    307. Xia Y, Karin M. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 2004 Feb; 14(2):94-101. PMID: 15102441.
      View in: PubMed
    308. Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 2004 Jan; 3(1):17-26. PMID: 14708018.
      View in: PubMed
    309. Chen F, Castranova V, Li Z, Karin M, Shi X. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res. 2003 Nov 15; 63(22):7689-93. PMID: 14633691.
      View in: PubMed
    310. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov; 23(21):7780-93. PMID: 14560022; PMCID: PMC207563.
      View in: PubMed, PubMed Central
    311. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37. PMID: 14614859.
      View in: PubMed
    312. Kato T, Delhase M, Hoffmann A, Karin M. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39. PMID: 14580335.
      View in: PubMed
    313. Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 01; 22(17):4443-54. PMID: 12941696; PMCID: PMC202382.
      View in: PubMed, PubMed Central
    314. Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J. 2003 Jul 01; 22(13):3356-66. PMID: 12839997; PMCID: PMC165656.
      View in: PubMed, PubMed Central
    315. Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L. Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003 May; 51(5):555-65. PMID: 12704203.
      View in: PubMed
    316. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 2003 May 01; 170(9):4630-7. PMID: 12707341.
      View in: PubMed
    317. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003 May; 9(5):575-81. PMID: 12692538.
      View in: PubMed
    318. Cao Y, Karin M. NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):215-23. PMID: 14635796.
      View in: PubMed
    319. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. PMID: 12689591.
      View in: PubMed
    320. Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. PMID: 12654254.
      View in: PubMed
    321. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. PMID: 12637498.
      View in: PubMed
    322. Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol. 2003 Feb; 23(3):1061-74. PMID: 12529410; PMCID: PMC140693.
      View in: PubMed, PubMed Central
    323. Maeda S, Karin M. Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 2003 Feb; 3(2):102-4. PMID: 12620404.
      View in: PubMed
    324. Shim J, Karin M. The control of mRNA stability in response to extracellular stimuli. Mol Cells. 2002 Dec 31; 14(3):323-31. PMID: 12521293.
      View in: PubMed
    325. Häcker H, Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2002 Dec; 2(6):431-3. PMID: 12498710.
      View in: PubMed
    326. Shim J, Lim H, R Yates J, Karin M. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell. 2002 Dec; 10(6):1331-44. PMID: 12504009.
      View in: PubMed
    327. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21; 420(6913):333-6. PMID: 12447443.
      View in: PubMed
    328. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002 Oct; 17(4):525-35. PMID: 12387745.
      View in: PubMed
    329. Makris C, Roberts JL, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002 Sep; 22(18):6573-81. PMID: 12192055; PMCID: PMC135629.
      View in: PubMed, PubMed Central
    330. Park JM, Greten FR, Li ZW, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002 Sep 20; 297(5589):2048-51. PMID: 12202685.
      View in: PubMed
    331. Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem. 2002 Oct 04; 277(40):37896-903. PMID: 12138127.
      View in: PubMed
    332. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun; 2(6):721-31. PMID: 12062085.
      View in: PubMed
    333. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002 May; 4(5):E131-6. PMID: 11988758.
      View in: PubMed
    334. Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1631-5. PMID: 11980884.
      View in: PubMed
    335. Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002 Apr; 2(4):301-10. PMID: 12001991.
      View in: PubMed
    336. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002 Apr; 109 Suppl:S81-96. PMID: 11983155.
      View in: PubMed
    337. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002 Mar; 3(3):221-7. PMID: 11875461.
      View in: PubMed
    338. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23. PMID: 11920420.
      View in: PubMed
    339. Senftleben U, Karin M. The IKK/NF-kappaB pathway. Crit Care Med. 2002 Jan; 30(1 Supp):S18-S26. PMID: 11891403.
      View in: PubMed
    340. Senftleben U, Karin M. The IKK/NF-kappa B pathway. Crit Care Med. 2002 Jan; 30(1 Suppl):S18-26. PMID: 11782557.
      View in: PubMed
    341. Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14; 107(6):763-75. PMID: 11747812.
      View in: PubMed
    342. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001 Nov 16; 107(4):451-64. PMID: 11719186.
      View in: PubMed
    343. Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24; 293(5534):1495-9. PMID: 11520989.
      View in: PubMed
    344. Karin M, Shaulian E. AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life. 2001 Jul; 52(1-2):17-24. PMID: 11795587.
      View in: PubMed
    345. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81. PMID: 11435459.
      View in: PubMed
    346. Karin M, Chang L. AP-1--glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol. 2001 Jun; 169(3):447-51. PMID: 11375114.
      View in: PubMed
    347. Piu F, Aronheim A, Katz S, Karin M. AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation. Mol Cell Biol. 2001 May; 21(9):3012-24. PMID: 11287607.
      View in: PubMed
    348. Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30; 20(19):2390-400. PMID: 11402335.
      View in: PubMed
    349. Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001 Apr 05; 410(6829):710-4. PMID: 11287960.
      View in: PubMed
    350. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001 Mar 01; 410(6824):37-40. PMID: 11242034.
      View in: PubMed
    351. Senftleben U, Li ZW, Baud V, Karin M. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity. 2001 Mar; 14(3):217-30. PMID: 11290332.
      View in: PubMed
    352. Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors. 2001; 15(2-4):87-9. PMID: 12016332.
      View in: PubMed
    353. Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem. 2001 Mar 23; 276(12):8898-903. PMID: 11114307.
      View in: PubMed
    354. Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, Lois A, Chen DJ, Li GC, Karin M, Raz E. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2000 Dec 08; 103(6):909-18. PMID: 11136976.
      View in: PubMed
    355. Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell. 2000 Dec 08; 103(6):897-907. PMID: 11136975.
      View in: PubMed
    356. Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17; 275(46):36062-6. PMID: 10967126.
      View in: PubMed
    357. Yoshida K, Hu Y, Karin M. IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3665-9. PMID: 11053261.
      View in: PubMed
    358. Delhase M, Li N, Karin M. Kinase regulation in inflammatory response. Nature. 2000 Jul 27; 406(6794):367-8. PMID: 10935625.
      View in: PubMed
    359. Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21; 102(2):221-31. PMID: 10943842.
      View in: PubMed
    360. López-Fernández J, Palacios D, Castillo AI, Tolon RM, Aranda A, Karin M. Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2. J Biol Chem. 2000 Jul 14; 275(28):21653-60. PMID: 10801832.
      View in: PubMed
    361. Makris C, Godfrey VL, Krähn-Senftleben G, Takahashi T, Roberts JL, Schwarz T, Feng L, Johnson RS, Karin M. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun; 5(6):969-79. PMID: 10911991.
      View in: PubMed
    362. Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL. p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol. 2000 Jun; 20(11):3951-64. PMID: 10805738.
      View in: PubMed
    363. Chen CY, Gherzi R, Andersen JS, Gaietta G, Jürchott K, Royer HD, Mann M, Karin M. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 2000 May 15; 14(10):1236-48. PMID: 10817758.
      View in: PubMed
    364. Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5243-8. PMID: 10805784.
      View in: PubMed
    365. Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 2000 Mar 01; 14(5):574-84. PMID: 10716945.
      View in: PubMed
    366. Karin M, Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol. 2000 Feb; 12(1):85-98. PMID: 10723801.
      View in: PubMed
    367. Li N, Karin M. Signaling pathways leading to nuclear factor-kappa B activation. Methods Enzymol. 2000; 319:273-9. PMID: 10907518.
      View in: PubMed
    368. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 2000; 18:621-63. PMID: 10837071.
      View in: PubMed
    369. Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 1999 Dec; 11(6):721-31. PMID: 10626894.
      View in: PubMed
    370. Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene. 1999 Nov 22; 18(49):6867-74. PMID: 10602462.
      View in: PubMed
    371. Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999 Oct 26; 1999(5):RE1. PMID: 11865184.
      View in: PubMed
    372. Shaulian E, Karin M. Stress-induced JNK activation is independent of Gadd45 induction. J Biol Chem. 1999 Oct 15; 274(42):29595-8. PMID: 10514425.
      View in: PubMed
    373. Karin M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem. 1999 Sep 24; 274(39):27339-42. PMID: 10488062.
      View in: PubMed
    374. Li N, Karin M. Is NF-kappaB the sensor of oxidative stress? FASEB J. 1999 Jul; 13(10):1137-43. PMID: 10385605.
      View in: PubMed
    375. Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 07; 189(11):1839-45. PMID: 10359587; PMCID: PMC2193082.
      View in: PubMed, PubMed Central
    376. Tian J, Karin M. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). J Biol Chem. 1999 May 21; 274(21):15173-80. PMID: 10329725.
      View in: PubMed
    377. Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15; 13(10):1297-308. PMID: 10346818.
      View in: PubMed
    378. Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science. 1999 Apr 09; 284(5412):316-20. PMID: 10195896.
      View in: PubMed
    379. Delhase M, Hayakawa M, Chen Y, Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science. 1999 Apr 09; 284(5412):309-13. PMID: 10195894.
      View in: PubMed
    380. Delhase M, Karin M. The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. Cold Spring Harb Symp Quant Biol. 1999; 64:491-503. PMID: 11232326.
      View in: PubMed
    381. Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999 Jan; 19(1):751-63. PMID: 9858598.
      View in: PubMed
    382. Xia Y, Wu Z, Su B, Murray B, Karin M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 01; 12(21):3369-81. PMID: 9808624.
      View in: PubMed
    383. Li N, Karin M. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13012-7. PMID: 9789032.
      View in: PubMed
    384. Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17; 395(6699):297-300. PMID: 9751060.
      View in: PubMed
    385. Zandi E, Chen Y, Karin M. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28; 281(5381):1360-3. PMID: 9721103.
      View in: PubMed
    386. Karin M, Delhase M. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9067-9. PMID: 9689033.
      View in: PubMed
    387. Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998 Jul 15; 18(14):5124-35. PMID: 9651196.
      View in: PubMed
    388. Karin M. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann N Y Acad Sci. 1998 Jun 30; 851:139-46. PMID: 9668616.
      View in: PubMed
    389. Chen CY, Del Gatto-Konczak F, Wu Z, Karin M. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science. 1998 Jun 19; 280(5371):1945-9. PMID: 9632395.
      View in: PubMed
    390. Werlen G, Jacinto E, Xia Y, Karin M. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 1998 Jun 01; 17(11):3101-11. PMID: 9606192.
      View in: PubMed
    391. Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 1998 May 15; 93(4):487-90. PMID: 9604923.
      View in: PubMed
    392. Karin M. The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. Cancer J Sci Am. 1998 May; 4 Suppl 1:S92-9. PMID: 9619277.
      View in: PubMed
    393. Jacinto E, Werlen G, Karin M. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 1998 Jan; 8(1):31-41. PMID: 9462509.
      View in: PubMed
    394. Wu Z, Wu J, Jacinto E, Karin M. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol Cell Biol. 1997 Dec; 17(12):7407-16. PMID: 9372971.
      View in: PubMed
    395. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17; 91(2):243-52. PMID: 9346241.
      View in: PubMed
    396. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 07; 388(6642):548-54. PMID: 9252186.
      View in: PubMed
    397. Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol Cell Biol. 1997 Aug; 17(8):4687-95. PMID: 9234725.
      View in: PubMed
    398. Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102. PMID: 9154808.
      View in: PubMed
    399. Karin M, Liu Zg, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol. 1997 Apr; 9(2):240-6. PMID: 9069263.
      View in: PubMed
    400. Auphan N, Didonato JA, Helmberg A, Rosette C, Karin M. Immunoregulatory genes and immunosuppression by glucocorticoids. Arch Toxicol Suppl. 1997; 19:87-95. PMID: 9079197.
      View in: PubMed
    401. Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29; 87(5):929-39. PMID: 8945519.
      View in: PubMed
    402. Reach M, Galindo RL, Towb P, Allen JL, Karin M, Wasserman SA. A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol. 1996 Nov 25; 180(1):353-64. PMID: 8948598.
      View in: PubMed
    403. Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M, Wang JY. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 1996 Nov 21; 384(6606):273-6. PMID: 8918879.
      View in: PubMed
    404. Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 1996 Nov 15; 15(22):6269-79. PMID: 8947050.
      View in: PubMed
    405. Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 1996 Nov 15; 274(5290):1194-7. PMID: 8895468.
      View in: PubMed
    406. Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 1996 Nov 01; 87(3):565-76. PMID: 8898208.
      View in: PubMed
    407. Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Mol Cell Biol. 1996 Nov; 16(11):5947-54. PMID: 8887624; PMCID: PMC231597.
      View in: PubMed, PubMed Central
    408. Claret FX, Hibi M, Dhut S, Toda T, Karin M. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 1996 Oct 03; 383(6599):453-7. PMID: 8837781.
      View in: PubMed
    409. Didonato JA, Saatcioglu F, Karin M. Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids. Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 2):S11-5. PMID: 8756781.
      View in: PubMed
    410. Collins LR, Minden A, Karin M, Brown JH. Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J Biol Chem. 1996 Jul 19; 271(29):17349-53. PMID: 8663428.
      View in: PubMed
    411. DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol. 1996 Apr; 16(4):1295-304. PMID: 8657102.
      View in: PubMed
    412. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):127-34. PMID: 8650258.
      View in: PubMed
    413. Claret FX, Antakly T, Karin M, Saatcioglu F. A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha. Mol Cell Biol. 1996 Jan; 16(1):219-27. PMID: 8524299.
      View in: PubMed
    414. Cavigelli M, Dolfi F, Claret FX, Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 1995 Dec 01; 14(23):5957-64. PMID: 8846788.
      View in: PubMed
    415. Caelles C, Hennemann H, Karin M. M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Mol Cell Biol. 1995 Dec; 15(12):6694-701. PMID: 8524234.
      View in: PubMed
    416. Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 1995 Oct 13; 270(5234):286-90. PMID: 7569976.
      View in: PubMed
    417. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995 Jul 14; 270(28):16483-6. PMID: 7622446.
      View in: PubMed
    418. Karin M, Hunter T. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol. 1995 Jul 01; 5(7):747-57. PMID: 7583121.
      View in: PubMed
    419. Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell. 1995 Jun 30; 81(7):1147-57. PMID: 7600582.
      View in: PubMed
    420. Yoshioka K, Deng T, Cavigelli M, Karin M. Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4972-6. PMID: 7761434.
      View in: PubMed
    421. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science. 1995 Apr 14; 268(5208):286-90. PMID: 7716521.
      View in: PubMed
    422. DiDonato JA, Mercurio F, Karin M. Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Mol Cell Biol. 1995 Mar; 15(3):1302-11. PMID: 7862124.
      View in: PubMed
    423. Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B. J Cell Biol. 1995 Mar; 128(6):1111-9. PMID: 7896875.
      View in: PubMed
    424. Helmberg A, Auphan N, Caelles C, Karin M. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 1995 Feb 01; 14(3):452-60. PMID: 7859735.
      View in: PubMed
    425. Smeal T, Hibi M, Karin M. Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. EMBO J. 1994 Dec 15; 13(24):6006-10. PMID: 7813438.
      View in: PubMed
    426. Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 1994 Dec 09; 266(5191):1719-23. PMID: 7992057.
      View in: PubMed
    427. Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol. 1994 Oct; 14(10):6683-8. PMID: 7935387.
      View in: PubMed
    428. Saatcioglu F, Claret FX, Karin M. Negative transcriptional regulation by nuclear receptors. Semin Cancer Biol. 1994 Oct; 5(5):347-59. PMID: 7849263.
      View in: PubMed
    429. Aronheim A, Engelberg D, Li N, al-Alawi N, Schlessinger J, Karin M. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell. 1994 Sep 23; 78(6):949-61. PMID: 7923364.
      View in: PubMed
    430. Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature. 1994 Sep 08; 371(6493):171-5. PMID: 8072547.
      View in: PubMed
    431. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature. 1994 Jul 21; 370(6486):220-3. PMID: 8028670.
      View in: PubMed
    432. Engelberg D, Zandi E, Parker CS, Karin M. The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol. 1994 Jul; 14(7):4929-37. PMID: 8007989.
      View in: PubMed
    433. Inouye C, Remondelli P, Karin M, Elledge S. Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994 Jul; 13(7):731-42. PMID: 7772254.
      View in: PubMed
    434. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 1994 Jun 03; 77(5):727-36. PMID: 8205621.
      View in: PubMed
    435. Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. J Clin Invest. 1994 Jun; 93(6):2554-61. PMID: 8200992.
      View in: PubMed
    436. Karin M. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin Cell Biol. 1994 Jun; 6(3):415-24. PMID: 7917334.
      View in: PubMed
    437. Engelberg D, Klein C, Martinetto H, Struhl K, Karin M. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 1994 May 06; 77(3):381-90. PMID: 8181058.
      View in: PubMed
    438. Saatcioglu F, Deng T, Karin M. A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation. Cell. 1993 Dec 17; 75(6):1095-105. PMID: 7903219.
      View in: PubMed
    439. Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 1993 Nov; 7(11):2135-48. PMID: 8224842.
      View in: PubMed
    440. Devary Y, Rosette C, DiDonato JA, Karin M. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science. 1993 Sep 10; 261(5127):1442-5. PMID: 8367725.
      View in: PubMed
    441. Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M, Chojkier M. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature. 1993 Aug 05; 364(6437):544-7. PMID: 8336793.
      View in: PubMed
    442. Saatcioglu F, Bartunek P, Deng T, Zenke M, Karin M. A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Mol Cell Biol. 1993 Jun; 13(6):3675-85. PMID: 8098843.
      View in: PubMed
    443. Alberts AS, Deng T, Lin A, Meinkoth JL, Schönthal A, Mumby MC, Karin M, Feramisco JR. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol Cell Biol. 1993 Apr; 13(4):2104-12. PMID: 8384305.
      View in: PubMed
    444. Mercurio F, DiDonato JA, Rosette C, Karin M. p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev. 1993 Apr; 7(4):705-18. PMID: 8458581.
      View in: PubMed
    445. Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. GHF-1-promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice. Genes Dev. 1993 Apr; 7(4):683-93. PMID: 8096199.
      View in: PubMed
    446. Deng T, Karin M. JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev. 1993 Mar; 7(3):479-90. PMID: 8383624.
      View in: PubMed
    447. Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. Activation of activating protein 1 during hepatic acute phase response. Am J Physiol. 1993 Jan; 264(1 Pt 1):G95-103. PMID: 8430810.
      View in: PubMed
    448. Ekström TJ, Klump WM, Getman D, Karin M, Taylor P. Promoter elements and transcriptional regulation of the acetylcholinesterase gene. DNA Cell Biol. 1993 Jan-Feb; 12(1):63-72. PMID: 8422273.
      View in: PubMed
    449. Karin M, Yang-Yen HF, Chambard JC, Deng T, Saatcioglu F. Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones. Eur J Clin Pharmacol. 1993; 45 Suppl 1:S9-15; discussion S43-4. PMID: 8313934.
      View in: PubMed
    450. Skroch P, Buchman C, Karin M. Regulation of human and yeast metallothionein gene transcription by heavy metal ions. Prog Clin Biol Res. 1993; 380:113-28. PMID: 8456121.
      View in: PubMed
    451. Lin A, Smeal T, Binetruy B, Deng T, Chambard JC, Karin M. Control of AP-1 activity by signal transduction cascades. Adv Second Messenger Phosphoprotein Res. 1993; 28:255-60. PMID: 8398411.
      View in: PubMed
    452. Devary Y, Gottlieb RA, Smeal T, Karin M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell. 1992 Dec 24; 71(7):1081-91. PMID: 1473146.
      View in: PubMed
    453. Trejo J, Chambard JC, Karin M, Brown JH. Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation. Mol Cell Biol. 1992 Oct; 12(10):4742-50. PMID: 1328861.
      View in: PubMed
    454. Karin M, Smeal T. Control of transcription factors by signal transduction pathways: the beginning of the end. Trends Biochem Sci. 1992 Oct; 17(10):418-22. PMID: 1455510.
      View in: PubMed
    455. Deng T, Karin M. Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8572-6. PMID: 1528863.
      View in: PubMed
    456. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 1992 Sep 04; 70(5):777-89. PMID: 1516134.
      View in: PubMed
    457. Mercurio F, Didonato J, Rosette C, Karin M. Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105. DNA Cell Biol. 1992 Sep; 11(7):523-37. PMID: 1388725.
      View in: PubMed
    458. Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol. 1992 Aug; 12(8):3507-13. PMID: 1630458.
      View in: PubMed
    459. Theill LE, Hattori K, Lazzaro D, Castrillo JL, Karin M. Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. EMBO J. 1992 Jun; 11(6):2261-9. PMID: 1600947.
      View in: PubMed
    460. Karin M. Signal transduction from cell surface to nucleus in development and disease. FASEB J. 1992 May; 6(8):2581-90. PMID: 1317309.
      View in: PubMed
    461. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature. 1991 Dec 12; 354(6353):494-6. PMID: 1749429.
      View in: PubMed
    462. Yang-Yen HF, Zhang XK, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M. Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New Biol. 1991 Dec; 3(12):1206-19. PMID: 1667479.
      View in: PubMed
    463. McCormick A, Brady H, Fukushima J, Karin M. The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. Genes Dev. 1991 Aug; 5(8):1490-503. PMID: 1869051.
      View in: PubMed
    464. Castrillo JL, Theill LE, Karin M. Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science. 1991 Jul 12; 253(5016):197-9. PMID: 1677216.
      View in: PubMed
    465. Karin M. Signal transduction and gene control. Curr Opin Cell Biol. 1991 Jun; 3(3):467-73. PMID: 1832548.
      View in: PubMed
    466. Binétruy B, Smeal T, Karin M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature. 1991 May 09; 351(6322):122-7. PMID: 1903181.
      View in: PubMed
    467. Devary Y, Gottlieb RA, Lau LF, Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol. 1991 May; 11(5):2804-11. PMID: 1901948.
      View in: PubMed
    468. Karin M, Theill L, Castrillo JL, McCormick A, Brady H. Cell type specific expression of the growth hormone gene and its control by GHF-1. Nihon Naibunpi Gakkai Zasshi. 1990 Dec 20; 66(12):1205-20. PMID: 2292312.
      View in: PubMed
    469. Hattori M, Tugores A, Veloz L, Karin M, Brenner DA. A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 1990 Dec; 9(10):777-81. PMID: 2264931.
      View in: PubMed
    470. Karin M. Transcriptional control and the integration of cell-autonomous and environmental cues during development. Curr Opin Cell Biol. 1990 Dec; 2(6):996-1002. PMID: 2099815.
      View in: PubMed
    471. Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 1990 Sep 21; 62(6):1205-15. PMID: 2169352.
      View in: PubMed
    472. Buchman C, Skroch P, Dixon W, Tullius TD, Karin M. A single amino acid change in CUP2 alters its mode of DNA binding. Mol Cell Biol. 1990 Sep; 10(9):4778-87. PMID: 2167439.
      View in: PubMed
    473. McCormick A, Brady H, Theill LE, Karin M. Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature. 1990 Jun 28; 345(6278):829-32. PMID: 1972784.
      View in: PubMed
    474. Radler-Pohl A, Pfeuffer I, Karin M, Serfling E. A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter. New Biol. 1990 Jun; 2(6):566-73. PMID: 2088505.
      View in: PubMed
    475. Yang-Yen HF, Chiu R, Karin M. Elevation of AP1 activity during F9 cell differentiation is due to increased c-jun transcription. New Biol. 1990 Apr; 2(4):351-61. PMID: 1963081.
      View in: PubMed
    476. Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M. DNA-binding activity of Jun is increased through its interaction with Fos. J Cell Biochem. 1990 Apr; 42(4):193-206. PMID: 2111328.
      View in: PubMed
    477. Karin M, Castrillo JL, Theill LE. Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. Trends Genet. 1990 Mar; 6(3):92-6. PMID: 2183418.
      View in: PubMed
    478. Karin M. Too many transcription factors: positive and negative interactions. New Biol. 1990 Feb; 2(2):126-31. PMID: 2128034.
      View in: PubMed
    479. Karin M, Theill L, Castrillo JL, McCormick A, Brady H. Tissue-specific expression of the growth hormone gene and its control by growth hormone factor-1. Recent Prog Horm Res. 1990; 46:43-57; discussion 57-8. PMID: 2281188.
      View in: PubMed
    480. Chiu R, Angel P, Karin M. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell. 1989 Dec 22; 59(6):979-86. PMID: 2513128.
      View in: PubMed
    481. Theill LE, Castrillo JL, Wu D, Karin M. Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature. 1989 Dec 21-28; 342(6252):945-8. PMID: 2574416.
      View in: PubMed
    482. Smeal T, Angel P, Meek J, Karin M. Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev. 1989 Dec; 3(12B):2091-100. PMID: 2516828.
      View in: PubMed
    483. Angel P, Smeal T, Meek J, Karin M. Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol. 1989 Oct; 1(1):35-43. PMID: 2518690.
      View in: PubMed
    484. Buchman C, Skroch P, Welch J, Fogel S, Karin M. The CUP2 gene product, regulator of yeast metallothionein expression, is a copper-activated DNA-binding protein. Mol Cell Biol. 1989 Sep; 9(9):4091-5. PMID: 2674688.
      View in: PubMed
    485. Mercurio F, Karin M. Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner. EMBO J. 1989 May; 8(5):1455-60. PMID: 2548845.
      View in: PubMed
    486. Dana S, Karin M. Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element. Mol Endocrinol. 1989 May; 3(5):815-21. PMID: 2547155.
      View in: PubMed
    487. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989 Feb 16; 337(6208):661-3. PMID: 2537468.
      View in: PubMed
    488. Castrillo JL, Bodner M, Karin M. Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. Science. 1989 Feb 10; 243(4892):814-7. PMID: 2563596.
      View in: PubMed
    489. Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell. 1988 Dec 02; 55(5):875-85. PMID: 3142689.
      View in: PubMed
    490. Hattori K, Angel P, Le Beau MM, Karin M. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9148-52. PMID: 3194415.
      View in: PubMed
    491. Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell. 1988 Nov 04; 55(3):505-18. PMID: 2902927.
      View in: PubMed
    492. McCormick A, Wu D, Castrillo JL, Dana S, Strobl J, Thompson EB, Karin M. Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell. 1988 Oct 21; 55(2):379-89. PMID: 3167985.
      View in: PubMed
    493. Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 1988 Aug 12; 54(4):541-52. PMID: 3135940.
      View in: PubMed
    494. Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature. 1988 Mar 10; 332(6160):166-71. PMID: 3347253.
      View in: PubMed
    495. Imagawa M, Chiu R, Karin M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell. 1987 Oct 23; 51(2):251-60. PMID: 2822255.
      View in: PubMed
    496. Chiu R, Imagawa M, Imbra RJ, Bockoven JR, Karin M. Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature. 1987 Oct 15-21; 329(6140):648-51. PMID: 2821407.
      View in: PubMed
    Michael's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (1415) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (135) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑