Loading...

Michael Karin

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0723
La Jolla CA 92093
Phone858-534-0872
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
    NIH U54CA260591Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH U01AA022614Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH R01CA163798Jul 16, 2012 - Apr 30, 2018
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Regulation of NF-kappaB and IKK by proinflammatory stimuli
    NIH R01AI043477May 1, 2010 - Dec 31, 2012
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH R01CA127923Apr 13, 2007 - Jul 31, 2011
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH R01CA118165Apr 1, 2007 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Jun 30, 2017
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH R01CA076188Feb 15, 1998 - Nov 30, 2001
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050May 15, 1997 - Dec 11, 1993
    Role: Co-Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Feb 1, 1996 - Aug 31, 1992
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH R01DK038527Jun 1, 1991 - Aug 31, 1995
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES004151Jan 1, 1986 - Jun 30, 1987
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Nov 30, 1991
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. BMJ Open. 2021 02 12; 11(2):e043584. PMID: 33579769.
      View in: PubMed   Mentions:    Fields:    
    2. Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 Jan 19. Hou J, Karin M, Sun B. PMID: 33469195.
      View in: PubMed   Mentions:    Fields:    
    3. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 Nov 23. Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596.
      View in: PubMed   Mentions:
    5. PKC?/? Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 Aug 10; 38(2):247-262.e11. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943.
      View in: PubMed   Mentions: 4     Fields:    
    6. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 06 17; 41(4):405-416. He F, Antonucci L, Karin M. PMID: 32347301.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214. Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781.
      View in: PubMed   Mentions: 1     Fields:    
    8. Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 03 04; 9(3). Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413.
      View in: PubMed   Mentions: 11     Fields:    
    9. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 Mar; 8(1). Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603.
      View in: PubMed   Mentions: 39     Fields:    
    10. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 Jun; 72(6):1182-1195. He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670.
      View in: PubMed   Mentions: 6     Fields:    
    11. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339.
      View in: PubMed   Mentions: 2     Fields:    
    12. Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 04 26; 38:649-671. Shalapour S, Karin M. PMID: 32040356.
      View in: PubMed   Mentions: 2     Fields:    
    13. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 Jul; 27(7):2206-2216. Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855.
      View in: PubMed   Mentions: 3     Fields:    
    15. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 2020 05; 72(5):960-975. Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
      View in: PubMed   Mentions:    Fields:    
    16. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
      View in: PubMed   Mentions:    Fields:    
    17. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189. Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190. Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions: 5     Fields:    
    20. Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-?B kinase subunit ß-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769. Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    21. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312. Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566.
      View in: PubMed   Mentions: 3     Fields:    
    22. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 09 01; 79(17):4326-4330. Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. PMID: 31481419.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    23. The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications. J Hepatol. 2020 01; 72(1):167-182. Hou J, Zhang H, Sun B, Karin M. PMID: 31449859.
      View in: PubMed   Mentions: 13     Fields:    
    24. Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. Immunity. 2019 07 16; 51(1):15-26. Shalapour S, Karin M. PMID: 31315033.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    25. The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 05 13; 35(5):714-720. Todoric J, Karin M. PMID: 31085174.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    26. Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    27. Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach. Mol Cancer Res. 2019 07; 17(7):1493-1502. Friemel J, Frick L, Unger K, Egger M, Parrotta R, Böge YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. PMID: 30967480.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003.
      View in: PubMed   Mentions: 3     Fields:    
    30. Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 01 08; 29(1):18-26. Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. PMID: 30449681.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    31. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    33. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    34. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714.
      View in: PubMed   Mentions:    Fields:    
    36. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    37. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    38. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    39. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    40. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 03; 25(3):486-541. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479.
      View in: PubMed   Mentions: 490     Fields:    Translation:HumansAnimalsCells
    41. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 05; 18(5):309-324. Taniguchi K, Karin M. PMID: 29379212.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    42. IKKa inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E812-E821. Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. PMID: 29311298.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    43. Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501.
      View in: PubMed   Mentions:    Fields:    
    44. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. PMID: 29153842.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    45. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    46. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1. PLoS One. 2017; 12(8):e0181052. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    47. IKKß inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 2017 10; 60(10):2021-2032. Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. PMID: 28725915.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 2017 Jul 19; 18(8):861-869. Afonina IS, Zhong Z, Karin M, Beyaert R. PMID: 28722711.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    49. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7414-7419. Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. PMID: 28652331.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    50. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 05; 24(5):929-943. Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. PMID: 28387757.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    51. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    52. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. PMID: 28130546.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    53. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat Immunol. 2017 03; 18(3):354-363. Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. PMID: 28114291.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    54. Corrigendum: PI3K? is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794.
      View in: PubMed   Mentions: 6     Fields:    
    55. Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prev Res (Phila). 2016 Dec; 9(12):895-905. Todoric J, Antonucci L, Karin M. PMID: 27913448.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    56. Inflammation Improves Glucose Homeostasis through IKKß-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. PMID: 27814504.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    57. p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 2016 Oct 20; 167(3):606-609. Moscat J, Karin M, Diaz-Meco MT. PMID: 27768885.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    58. p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 2016 10 10; 30(4):595-609. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. PMID: 27728806.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    59. PI3K? is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    60. I?B kinasea/ß control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology. 2016 10; 64(4):1217-31. Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. PMID: 27396433.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    61. p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 2016 08; 590(15):2375-97. Taniguchi K, Yamachika S, He F, Karin M. PMID: 27404485.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    62. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27586797.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    63. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27419869.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimals
    64. Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. Cell Rep. 2016 06 28; 16(1):120-132. McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS. PMID: 27320908.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    65. Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 2016 06 07; 9(431):re5. Lee JH, Cho US, Karin M. PMID: 27273098.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    66. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 27211490.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    67. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 05 17; 7:11551. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. PMID: 27187615.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    68. Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. Cell Metab. 2016 05 10; 23(5):759-61. Shalapour S, Karin M. PMID: 27166937.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    69. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis. 2016 06; 37(6):541-6. Karin M, Dhar D. PMID: 27207669.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    70. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    71. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399.
      View in: PubMed   Mentions:
    72. Reparative inflammation takes charge of tissue regeneration. Nature. 2016 Jan 21; 529(7586):307-15. Karin M, Clevers H. PMID: 26791721.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    73. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. PMID: 26792803.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    74. Obesity and Cancer: The Oil that Feeds the Flame. Cell Metab. 2016 Jan 12; 23(1):48-62. Font-Burgada J, Sun B, Karin M. PMID: 26771116.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    75. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5. Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. PMID: 26554006.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    76. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun. 2015 Nov 02; 6:8695. Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. PMID: 26522614.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    77. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6166-74. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. PMID: 26512112.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    78. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44. Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. PMID: 26502405.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    79. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nat Commun. 2015 Oct 12; 6:8428. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. PMID: 26455434.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    80. The IL-23 to IL-17 cascade inflammation-related cancers. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S87-90. Wang K, Karin M. PMID: 26457610.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    81. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. PMID: 26390293.
      View in: PubMed   Mentions: 3     Fields:    
    82. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2016 05 19; 35(20):2634-44. Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. PMID: 26364612.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    83. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015 Sep; 125(9):3347-55. Shalapour S, Karin M. PMID: 26325032.
      View in: PubMed   Mentions: 186     Fields:    Translation:HumansAnimalsCells
    84. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    85. Immune Infiltration and Prostate Cancer. Front Oncol. 2015; 5:128. Strasner A, Karin M. PMID: 26217583.
      View in: PubMed   Mentions:
    86. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 Jul; 266(1):161-74. Wu X, Karin M. PMID: 26085214.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    87. Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev. 2015 Aug; 26(4):389-403. Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. PMID: 26119834.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    88. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. PMID: 26109050.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    89. Tumor-Elicited Inflammation and Colorectal Cancer. Adv Cancer Res. 2015; 128:173-96. Wang K, Karin M. PMID: 26216633.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    90. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. PMID: 25924065.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    91. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. PMID: 25909884.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    92. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. PMID: 25819761.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    93. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    94. Analysis of NF-κB activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. Shaked H, Guma M, Karin M. PMID: 25736774.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    95. IKKß in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5. Cell Death Differ. 2015 May; 22(5):852-61. Kobayashi K, Toguchida J, Karin M, Kato T. PMID: 25526093.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    96. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63. PMID: 25526314.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    97. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. PMID: 25457612.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    98. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    99. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015 Feb; 29(2):408-17. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. PMID: 25366347.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    100. Myeloid IKKß promotes antitumor immunity by modulating CCL11 and the innate immune response. Cancer Res. 2014 Dec 15; 74(24):7274-84. PMID: 25336190.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    101. Whipping NF-κB to Submission via GADD45 and MKK7. Cancer Cell. 2014 Oct 13; 26(4):447-9. Karin M. PMID: 25314072.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    102. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014 Oct 13; 26(4):549-64. PMID: 25314080.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    103. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    104. IKKa negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. PMID: 25266676.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    105. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. PMID: 25267627.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    106. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 03; 33(21):2581-96. PMID: 25260751.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    107. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 26594598.
      View in: PubMed   Mentions:
    108. Roles of tumor suppressors in regulating tumor-associated inflammation. Cell Death Differ. 2014 Nov; 21(11):1677-86. Yang L, Karin M. PMID: 25190145.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    109. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. PMID: 25189770.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    110. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    111. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nat Commun. 2014 Jul 29; 5:4513. PMID: 25072696.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    112. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    113. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. PMID: 24910242.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    114. The therapeutic value of targeting inflammation in gastrointestinal cancers. Trends Pharmacol Sci. 2014 Jul; 35(7):349-57. PMID: 24881011.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    115. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. PMID: 24735923.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    116. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 2014 Feb; 26(1):54-74. PMID: 24552665.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    117. Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med. 2014 Feb; 20(2):126-7. PMID: 24504404.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    118. Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014 Jan 30; 12:30. PMID: 24475900.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    119. Critical role for IL-1ß in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11. PMID: 24469832.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    120. Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PLoS One. 2014; 9(1):e83391. PMID: 24416163.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    121. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7. PMID: 24411937.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    122. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1090-5. PMID: 24395807.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    123. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91. PMID: 24333183.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    124. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    125. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. PMID: 24120137.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    126. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal. 2013 Oct 01; 6(295):ra87. PMID: 24084649.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    127. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 03; 18(6):792-801. PMID: 24055102.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    128. IKKß in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunol. 2014 Mar; 7(2):257-67. Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, Davis IC, Lin M, Tomé D, Karin M, Sun Y, Boyaka PN. PMID: 23839064.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    129. An IKKa-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes Dev. 2013 Jul 01; 27(13):1435-40. PMID: 23796898.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    130. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1199-209.e4. PMID: 23622129.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    131. Inflammation and liver tumorigenesis. Front Med. 2013 Jun; 7(2):242-54. PMID: 23681888.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    132. A NIK-IKKa module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59. PMID: 23602409.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    133. Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43. PMID: 23563314.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    134. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog. 2013 Mar; 9(3):e1003234. PMID: 23555249.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    135. I kappa B kinase alpha (IKKa) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20; 32(6):816-28. PMID: 23422957.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    136. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. PMID: 23341606.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    137. Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975. PMID: 24516778.
      View in: PubMed   Mentions:
    138. p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24. PMID: 23271722.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    139. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3. PMID: 23253923.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    140. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 04; 288(1):598-607. PMID: 23155052.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    141. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. PMID: 23034650.
      View in: PubMed   Mentions: 396     Fields:    Translation:HumansAnimalsCells
    142. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21. PMID: 22959272.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    143. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    144. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    145. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. PMID: 22893683.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    146. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93. PMID: 22865915.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    147. The pore-forming toxin ß hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812. PMID: 22829768.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    148. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    149. CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2. PMID: 22698394.
      View in: PubMed   Mentions: 3     Fields:    
    150. IKKa-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77. PMID: 22544702.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    151. I?B kinase ß (IKKß) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J. 2012 Mar 15; 442(3):723-32. Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. PMID: 22364283.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    152. Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4. PMID: 22320909.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    153. NF-κB and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400. DiDonato JA, Mercurio F, Karin M. PMID: 22435567.
      View in: PubMed   Mentions: 438     Fields:    Translation:HumansAnimalsCells
    154. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):E177-86. PMID: 22203995.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    155. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. PMID: 22196886.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    156. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47. PMID: 22153071.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    157. Obesity, inflammation, and liver cancer. J Hepatol. 2012 Mar; 56(3):704-13. PMID: 22120206.
      View in: PubMed   Mentions: 146     Fields:    Translation:Humans
    158. Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507. Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. PMID: 22389871.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    159. Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77. PMID: 22035839.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    160. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    161. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84. Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. PMID: 21962514.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    162. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011 Sep; 134(Pt 9):2722-35. Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. PMID: 21908876.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    163. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14. PMID: 21815634.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    164. Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. PMID: 21825016.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    165. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13710-5. PMID: 21807998.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    166. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011 Jul 19; 12(8):715-23. Ben-Neriah Y, Karin M. PMID: 21772280.
      View in: PubMed   Mentions: 497     Fields:    Translation:HumansAnimals
    167. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44. PMID: 21683629.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    168. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 2011 Jun 14; 19(6):740-53. PMID: 21665148.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    169. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011 Jun 10; 11(7):457-68. Häcker H, Tseng PH, Karin M. PMID: 21660053.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    170. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. PMID: 21305529.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    171. IKK-ß-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 2011 May; 41(5):1266-77. Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. PMID: 21469085.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    172. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 2011 Apr 12; 19(4):429-31. Li N, Grivennikov SI, Karin M. PMID: 21481782.
      View in: PubMed   Mentions: 110     Fields:    
    173. Crystal structure of inhibitor of ?B kinase ß. Nature. 2011 Apr 21; 472(7343):325-30. Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. PMID: 21423167.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    174. Transcriptional regulation of the Th17 immune response by IKK(alpha). J Exp Med. 2011 Apr 11; 208(4):787-96. Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. PMID: 21402739.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    175. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i104-8. PMID: 21339211.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimals
    176. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. PMID: 21326202.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansAnimalsCells
    177. Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011 Jan; 1217:191-206. Kim S, Karin M. PMID: 21276007.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    178. IKKß regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318. Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. PMID: 21587235.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    179. NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011 Jan; 21(1):159-68. He G, Karin M. PMID: 21187858.
      View in: PubMed   Mentions: 336     Fields:    Translation:AnimalsCells
    180. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    181. IL-1ß-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKß. Nat Immunol. 2011 Feb; 12(2):144-50. Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. PMID: 21170027.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    182. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. PMID: 21135226.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    183. Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. . 2010 Dec 08; 10(12):5088-92. Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S. PMID: 21038917.
      View in: PubMed   Mentions:
    184. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60. Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. PMID: 20956327.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    185. Peering into the aftermath: JAKi rips STAT3 in cancer. Nat Med. 2010 Oct; 16(10):1085-7. Greten FR, Karin M. PMID: 20930749.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    186. Stressin' Sestrins take an aging fight. EMBO Mol Med. 2010 Oct; 2(10):388-400. Budanov AV, Lee JH, Karin M. PMID: 20878915.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    187. Sphingolipids: the oil on the TRAFire that promotes inflammation. Sci Signal. 2010 Sep 28; 3(141):pe34. Napolitano G, Karin M. PMID: 20876871.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    188. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75. Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. PMID: 20841473.
      View in: PubMed   Mentions: 202     Fields:    Translation:AnimalsCells
    189. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010 Sep 24; 33(3):400-11. Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, Lebon P, Rozenberg F, Karin M, Tardieu M, Al-Muhsen S, Jouanguy E, Zhang SY, Abel L, Casanova JL. PMID: 20832341.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansCells
    190. Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27; 39(4):570-82. Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. PMID: 20797629.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    191. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest. 2010 Jul; 120(7):2563-74. Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. PMID: 20530876.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    192. Inflammation and colon cancer. Gastroenterology. 2010 Jun; 138(6):2101-2114.e5. Terzic J, Grivennikov S, Karin E, Karin M. PMID: 20420949.
      View in: PubMed   Mentions: 599     Fields:    Translation:HumansAnimalsCells
    193. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    194. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12. Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. PMID: 20494824.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    195. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimals
    196. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010 Aug; 24(8):2596-611. Solinas G, Karin M. PMID: 20371626.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    197. Immunity, inflammation, and cancer. Cell. 2010 Mar 19; 140(6):883-99. Grivennikov SI, Greten FR, Karin M. PMID: 20303878.
      View in: PubMed   Mentions: 2918     Fields:    Translation:HumansAnimals
    198. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. PMID: 20227042.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    199. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010 Mar 11; 464(7286):302-5. Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. PMID: 20220849.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    200. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043.
      View in: PubMed   Mentions: 208     Fields:    Translation:AnimalsCells
    201. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-15. Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. PMID: 20097762.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    202. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010 Jan 22; 140(2):197-208. Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. PMID: 20141834.
      View in: PubMed   Mentions: 551     Fields:    Translation:Animals
    203. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97. Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. PMID: 20129250.
      View in: PubMed   Mentions: 175     Fields:    Translation:AnimalsPHPublic Health
    204. Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010 Feb; 20(1):65-71. Grivennikov SI, Karin M. PMID: 20036794.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    205. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010 Feb; 21(1):11-9. Grivennikov SI, Karin M. PMID: 20018552.
      View in: PubMed   Mentions: 378     Fields:    Translation:HumansAnimalsCells
    206. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J Immunol. 2009 Dec 15; 183(12):7877-89. Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. PMID: 20007573.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    207. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 2010 Mar; 138(3):1022-34.e1-10. Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. PMID: 19962981.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    208. Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology. 2009 Dec; 50(6):1851-60. Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. PMID: 19821485.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    209. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. PMID: 19950258.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    210. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan; 11(1):70-5. Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. PMID: 19898473.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    211. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a000141. Karin M. PMID: 20066113.
      View in: PubMed   Mentions: 311     Fields:    Translation:HumansAnimalsCells
    212. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 06; 16(4):295-308. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. PMID: 19800575.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    213. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009 Nov 12; 114(20):4469-76. Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. PMID: 19755673.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    214. MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol. 2009 Sep 15; 183(6):3831-8. Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. PMID: 19710465.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    215. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009 Aug 19; 4(8):e6695. Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. PMID: 19690611.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    216. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    217. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    218. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev. 2009 Mar; 228(1):225-40. Karin M, Gallagher E. PMID: 19290931.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    219. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. PMID: 19203587.
      View in: PubMed   Mentions:    Fields:    
    220. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. PMID: 19185845.
      View in: PubMed   Mentions: 757     Fields:    Translation:HumansAnimalsCells
    221. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54. Koch KS, Maeda S, He G, Karin M, Leffert HL. PMID: 19171122.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    222. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733. Vallabhapurapu S, Karin M. PMID: 19302050.
      View in: PubMed   Mentions: 893     Fields:    Translation:HumansAnimalsCells
    223. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009 Jan 01; 457(7225):102-6. Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M. PMID: 19122641.
      View in: PubMed   Mentions: 407     Fields:    Translation:AnimalsCells
    224. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009 Jan; 8(1):33-40. Baud V, Karin M. PMID: 19116625.
      View in: PubMed   Mentions: 391     Fields:    Translation:HumansAnimalsCells
    225. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20197-202. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA. PMID: 19091944.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    226. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. PMID: 19001420.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    227. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec; 9(12):1364-70. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. PMID: 18997792.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansAnimalsCells
    228. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17091-6. Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. PMID: 18957551.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    229. NF-kappaB signaling, liver disease and hepatoprotective agents. Oncogene. 2008 Oct 20; 27(48):6228-44. Sun B, Karin M. PMID: 18931690.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    230. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13. Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. PMID: 18922779.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    231. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008 Oct 03; 135(1):61-73. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. PMID: 18854155.
      View in: PubMed   Mentions: 440     Fields:    Translation:HumansAnimalsCells
    232. Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35. Hou Y, Li F, Karin M, Ostrowski MC. PMID: 18816823.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    233. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain. 2008 Nov; 131(Pt 11):3019-33. Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ. PMID: 18819987.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    234. IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J. 2008 Oct 22; 27(20):2639-47. Descargues P, Sil AK, Karin M. PMID: 18818691.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    235. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63. Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. PMID: 18815378.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    236. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65. Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. PMID: 18691550.
      View in: PubMed   Mentions: 180     Fields:    Translation:AnimalsCells
    237. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 08; 134(3):451-60. Budanov AV, Karin M. PMID: 18692468.
      View in: PubMed   Mentions: 471     Fields:    Translation:HumansAnimalsCells
    238. Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One. 2008 Jul 23; 3(7):e2769. Meinzer U, Esmiol-Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, Chareyre F, Niwa-Kawakita M, Alberti C, Sterkers G, Villard C, Lesuffleur T, Peuchmaur M, Karin M, Eckmann L, Giovannini M, Ollendorff V, Wolf-Watz H, Hugot JP. PMID: 18648508.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    239. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008 Aug 01; 321(5889):663-8. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. PMID: 18635759.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    240. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9. Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. PMID: 18633439.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    241. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008 Oct; 135(4):1311-21. Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M. PMID: 18700144.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    242. The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 2008 Jul 08; 14(1):10-21. Bernassola F, Karin M, Ciechanover A, Melino G. PMID: 18598940.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    243. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008 Jul 01; 68(13):5031-9. Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. PMID: 18593901.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    244. Prion propagation in mice lacking central nervous system NF-kappaB signalling. J Gen Virol. 2008 Jun; 89(Pt 6):1545-1550. Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A. PMID: 18474572.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    245. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. PMID: 18511561.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    246. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76. Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. PMID: 18490491.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    247. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 2008 Feb; 18(1):19-26. Naugler WE, Karin M. PMID: 18440219.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansCells
    248. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192.
      View in: PubMed   Mentions: 486     Fields:    Translation:AnimalsCells
    249. The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 2008 Mar; 18(3):334-42. Karin M. PMID: 18301380.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimals
    250. Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell. 2008 Feb 15; 29(3):279-90. Herrlich P, Karin M, Weiss C. PMID: 18280234.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    251. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2487-92. Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M. PMID: 18268325.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    252. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008 Mar; 14(3):109-19. Naugler WE, Karin M. PMID: 18261959.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    253. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell. 2008 Jan; 13(1):7-9. Grivennikov S, Karin M. PMID: 18167335.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    254. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec; 220:8-21. Temkin V, Karin M. PMID: 17979836.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    255. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. PMID: 17983584.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
    256. Rsk Tolls the bell for endocytosis in DCs. Nat Immunol. 2007 Nov; 8(11):1197-9. Karin M. PMID: 17952046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    257. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90. Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. PMID: 17924664.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    258. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15852-7. Cao Y, Luo JL, Karin M. PMID: 17890319.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    259. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. PMID: 17803913.
      View in: PubMed   Mentions: 241     Fields:    Translation:HumansAnimalsCells
    260. Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res. 2007 Sep 01; 13(17):4956-9. Van Waes C, Yu M, Nottingham L, Karin M. PMID: 17785544.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    261. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 Jul 06; 317(5834):121-4. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. PMID: 17615358.
      View in: PubMed   Mentions: 647     Fields:    Translation:AnimalsCells
    262. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May; 117(5):1175-83. Lin WW, Karin M. PMID: 17476347.
      View in: PubMed   Mentions: 543     Fields:    Translation:HumansAnimals
    263. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Crit Care Med. 2007 May; 35(5):1332-40. Chen LW, Chen PH, Chang WJ, Wang JS, Karin M, Hsu CM. PMID: 17414734.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    264. Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6359-64. Mills DM, Bonizzi G, Karin M, Rickert RC. PMID: 17404218.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    265. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. PMID: 17380205.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    266. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. PMID: 17377533.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimalsCells
    267. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007 Mar 29; 446(7135):552-6. Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. PMID: 17322906.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    268. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. PMID: 17360634.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    269. NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1913-8. Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. PMID: 17267600.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    270. Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 2007; 602:125-34. Ruocco MG, Karin M. PMID: 17966397.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    271. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos. 2007 Mar; 35(3):402-9. Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ. PMID: 17151194.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    272. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007 Jan; 8(1):57-63. Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. PMID: 17143273.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    273. Role for IKK2 in muscle: waste not, want not. J Clin Invest. 2006 Nov; 116(11):2866-8. Karin M. PMID: 17080193.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    274. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 01; 177(9):6344-52. Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. PMID: 17056565.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    275. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16454-9. Solinas G, Naugler W, Galimi F, Lee MS, Karin M. PMID: 17050683.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    276. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17; 2006(357):re13. Häcker H, Karin M. PMID: 17047224.
      View in: PubMed   Mentions: 493     Fields:    Translation:HumansAnimalsCells
    277. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10. Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. PMID: 16973958.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    278. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem. 2006 Dec 01; 281(48):37142-9. Chen F, Lu Y, Castranova V, Li Z, Karin M. PMID: 16966325.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    279. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15. Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. PMID: 16973390.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    280. MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. Eur J Immunol. 2006 Aug; 36(8):2076-84. Labuda T, Christensen JP, Rasmussen S, Bonnesen B, Karin M, Thomsen AR, Odum N. PMID: 16761309.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    281. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007 Feb 08; 26(6):851-8. Lin R, Maeda S, Liu C, Karin M, Edgington TS. PMID: 16878148.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansAnimalsCells
    282. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20. Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. PMID: 16818780.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    283. Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 06; 442(7098):39-44. Meylan E, Tschopp J, Karin M. PMID: 16823444.
      View in: PubMed   Mentions: 361     Fields:    Translation:HumansAnimals
    284. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. PMID: 16818881.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    285. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10544-51. Sakurai T, Maeda S, Chang L, Karin M. PMID: 16807293.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    286. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun; 45(6):355-61. Karin M. PMID: 16673382.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    287. Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25; 441(7092):431-6. Karin M. PMID: 16724054.
      View in: PubMed   Mentions: 1217     Fields:    Translation:HumansAnimals
    288. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-68. Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. PMID: 16717090.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    289. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006 Apr; 116(4):1117-26. Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. PMID: 16557301.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    290. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35. Karin M, Lawrence T, Nizet V. PMID: 16497591.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimalsCells
    291. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006 Feb 10; 124(3):601-13. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. PMID: 16469705.
      View in: PubMed   Mentions: 258     Fields:    Translation:AnimalsCells
    292. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2292-7. Mahieu T, Park JM, Revets H, Pasche B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. PMID: 16455798.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    293. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. PMID: 16455799.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    294. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1717-22. Gallagher E, Gao M, Liu YC, Karin M. PMID: 16446428.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    295. Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lect. 2006-2007; 102:133-51. Karin M. PMID: 20166567.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    296. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005 Dec 22; 20(6):891-903. Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R. PMID: 16364914.
      View in: PubMed   Mentions: 108     Fields:    Translation:AnimalsCells
    297. Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 2005 Dec; 5(12):941-52. Liu YC, Penninger J, Karin M. PMID: 16322747.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    298. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. PMID: 16317067.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    299. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. PMID: 16306937.
      View in: PubMed   Mentions: 300     Fields:    Translation:AnimalsCells
    300. The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005 Nov; 25(6):541-50. Luo JL, Kamata H, Karin M. PMID: 16380818.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    301. IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis. 2005 Nov; 64 Suppl 4:iv81-5. Ruocco MG, Karin M. PMID: 16239395.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    302. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005 Oct; 5(10):749-59. Karin M, Greten FR. PMID: 16175180.
      View in: PubMed   Mentions: 982     Fields:    Translation:HumansAnimalsCells
    303. IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest. 2005 Oct; 115(10):2625-32. Luo JL, Kamata H, Karin M. PMID: 16200195.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    304. Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell. 2005 Sep 02; 19(5):581-93. Gao M, Karin M. PMID: 16137616.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    305. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. PMID: 16169504.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    306. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. PMID: 15989949.
      View in: PubMed   Mentions: 424     Fields:    Translation:AnimalsCells
    307. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. . 2005 Jun; 6(6):531-7. Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Chuang T, Tuthill C, Wan Y, Karin M, Chu WM. PMID: 15905851.
      View in: PubMed   Mentions:
    308. NOD2 and Crohn's disease: loss or gain of function? Immunity. 2005 Jun; 22(6):661-7. Eckmann L, Karin M. PMID: 15963781.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    309. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005 May 16; 201(10):1677-87. Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. PMID: 15897281.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    310. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. PMID: 15858576.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    311. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life. 2005 Apr-May; 57(4-5):283-95. Karin M, Gallagher E. PMID: 16036612.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    312. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11; 120(5):649-61. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. PMID: 15766528.
      View in: PubMed   Mentions: 601     Fields:    Translation:HumansAnimalsCells
    313. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. PMID: 15692052.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    314. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
      View in: PubMed   Mentions: 630     Fields:    Translation:AnimalsCells
    315. Inflammation and cancer: the long reach of Ras. Nat Med. 2005 Jan; 11(1):20-1. Karin M. PMID: 15635437.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    316. Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005; 2(4):386-90; discussion 394-5. Karin M. PMID: 16267367.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    317. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004 Dec 20; 200(12):1647-55. Park JM, Ng VH, Maeda S, Rest RF, Karin M. PMID: 15611291.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    318. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8. Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. PMID: 15601766.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    319. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol. 2004 Nov 15; 173(10):6161-8. Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH. PMID: 15528353.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    320. Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Ann Rheum Dis. 2004 Nov; 63 Suppl 2:ii62-ii64. Karin M. PMID: 15479874.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    321. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. PMID: 15470505.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    322. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell. 2004 Sep 10; 15(5):713-25. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. PMID: 15350216.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    323. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 08; 306(5694):271-5. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. PMID: 15358865.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    324. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004 Sep; 6(3):297-305. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. PMID: 15380520.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    325. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. PMID: 15294155.
      View in: PubMed   Mentions: 869     Fields:    Translation:AnimalsCells
    326. CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. J Neuroimmunol. 2004 Aug; 153(1-2):50-63. Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ. PMID: 15265663.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    327. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol. 2004 Jul; 24(13):5914-22. Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG. PMID: 15199146.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    328. Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol. 2004 Jul; 41(6-7):701-14. Li ZW, Rickert RC, Karin M. PMID: 15220005.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    329. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell. 2004 Jun 04; 14(5):571-83. Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY. PMID: 15175153.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    330. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004 Jun; 25(6):280-8. Bonizzi G, Karin M. PMID: 15145317.
      View in: PubMed   Mentions: 756     Fields:    Translation:AnimalsCells
    331. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004 Apr 08; 206(2):193-9. Greten FR, Karin M. PMID: 15013524.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    332. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4. Sil AK, Maeda S, Sano Y, Roop DR, Karin M. PMID: 15071597.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    333. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 2004 Apr 01; 23(14):2540-7. Amir RE, Haecker H, Karin M, Ciechanover A. PMID: 14676825.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    334. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    335. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. PMID: 15029200.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    336. Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 2004 Mar 01; 18(5):584-94. Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. PMID: 15037551.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    337. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. PMID: 14983030.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    338. A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb; 6(2):219-27. Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT. PMID: 14960276.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    339. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 2004 Feb; 14(2):94-101. Xia Y, Karin M. PMID: 15102441.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    340. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 2004 Jan; 3(1):17-26. Karin M, Yamamoto Y, Wang QM. PMID: 14708018.
      View in: PubMed   Mentions: 368     Fields:    Translation:HumansAnimalsCells
    341. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res. 2003 Nov 15; 63(22):7689-93. Chen F, Castranova V, Li Z, Karin M, Shi X. PMID: 14633691.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    342. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. PMID: 14614859.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    343. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov; 23(21):7780-93. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. PMID: 14560022.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    344. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39. Kato T, Delhase M, Hoffmann A, Karin M. PMID: 14580335.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    345. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 01; 22(17):4443-54. Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. PMID: 12941696.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    346. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J. 2003 Jul 01; 22(13):3356-66. Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. PMID: 12839997.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    347. Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003 May; 51(5):555-65. Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L. PMID: 12704203.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    348. IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 2003 May 01; 170(9):4630-7. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. PMID: 12707341.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    349. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003 May; 9(5):575-81. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. PMID: 12692538.
      View in: PubMed   Mentions: 163     Fields:    Translation:Animals
    350. NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):215-23. Cao Y, Karin M. PMID: 14635796.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    351. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. PMID: 12689591.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    352. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. Lin A, Karin M. PMID: 12654254.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    353. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    354. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol. 2003 Feb; 23(3):1061-74. Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. PMID: 12529410.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    355. Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 2003 Feb; 3(2):102-4. Maeda S, Karin M. PMID: 12620404.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    356. The control of mRNA stability in response to extracellular stimuli. Mol Cells. 2002 Dec 31; 14(3):323-31. Shim J, Karin M. PMID: 12521293.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    357. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell. 2002 Dec; 10(6):1331-44. Shim J, Lim H, R Yates J, Karin M. PMID: 12504009.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    358. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2002 Dec; 2(6):431-3. Häcker H, Karin M. PMID: 12498710.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    359. A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21; 420(6913):333-6. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 12447443.
      View in: PubMed   Mentions: 1013     Fields:    Translation:AnimalsCells
    360. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002 Oct; 17(4):525-35. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. PMID: 12387745.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansAnimalsCells
    361. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002 Sep; 22(18):6573-81. Makris C, Roberts JL, Karin M. PMID: 12192055.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    362. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002 Sep 20; 297(5589):2048-51. Park JM, Greten FR, Li ZW, Karin M. PMID: 12202685.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    363. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem. 2002 Oct 04; 277(40):37896-903. Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. PMID: 12138127.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    364. Redundant pathways for negative feedback regulation of bile acid production. Dev Cell. 2002 Jun; 2(6):721-31. Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. PMID: 12062085.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    365. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002 May; 4(5):E131-6. Shaulian E, Karin M. PMID: 11988758.
      View in: PubMed   Mentions: 750     Fields:    Translation:AnimalsCells
    366. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1631-5. Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. PMID: 11980884.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    367. Missing pieces in the NF-kappaB puzzle. Cell. 2002 Apr; 109 Suppl:S81-96. Ghosh S, Karin M. PMID: 11983155.
      View in: PubMed   Mentions: 1048     Fields:    Translation:HumansAnimalsCells
    368. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002 Apr; 2(4):301-10. Karin M, Cao Y, Greten FR, Li ZW. PMID: 12001991.
      View in: PubMed   Mentions: 768     Fields:    Translation:HumansAnimalsCells
    369. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. PMID: 11920420.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    370. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002 Mar; 3(3):221-7. Karin M, Lin A. PMID: 11875461.
      View in: PubMed   Mentions: 787     Fields:    Translation:HumansAnimals
    371. The IKK/NF-kappa B pathway. Crit Care Med. 2002 Jan; 30(1 Suppl):S18-26. Senftleben U, Karin M. PMID: 11782557.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    372. The IKK/NF-kappaB pathway. Crit Care Med. 2002 Jan; 30(1 Supp):S18-S26. Senftleben U, Karin M. PMID: 11891403.
      View in: PubMed   Mentions: 29     Fields:    
    373. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14; 107(6):763-75. Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. PMID: 11747812.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    374. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001 Nov 16; 107(4):451-64. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. PMID: 11719186.
      View in: PubMed   Mentions: 345     Fields:    Translation:HumansAnimalsCells
    375. Inhibition of JNK activation through NF-kappaB target genes. Nature. 2001 Nov 15; 414(6861):313-7. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. PMID: 11713531.
      View in: PubMed   Mentions: 224     Fields:    Translation:HumansAnimalsCells
    376. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 Sep; 11(9):372-7. Baud V, Karin M. PMID: 11514191.
      View in: PubMed   Mentions: 400     Fields:    Translation:Cells
    377. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001 Aug 31; 293(5535):1673-7. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. PMID: 11533494.
      View in: PubMed   Mentions: 560     Fields:    Translation:AnimalsCells
    378. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24; 293(5534):1495-9. Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. PMID: 11520989.
      View in: PubMed   Mentions: 433     Fields:    Translation:AnimalsCells
    379. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest. 2001 Aug; 108(3):437-46. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. PMID: 11489937.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    380. AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life. 2001 Jul; 52(1-2):17-24. Karin M, Shaulian E. PMID: 11795587.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    381. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. PMID: 11435459.
      View in: PubMed   Mentions: 208     Fields:    Translation:AnimalsCells
    382. c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene. 2001 Jun 07; 20(26):3443-8. Jiménez B, Volpert OV, Reiher F, Chang L, Muñoz A, Karin M, Bouck N. PMID: 11423995.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    383. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol Cell Biol. 2001 Jun; 21(12):3986-94. Devin A, Lin Y, Yamaoka S, Li Z, Karin M. PMID: 11359906.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    384. AP-1--glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol. 2001 Jun; 169(3):447-51. Karin M, Chang L. PMID: 11375114.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    385. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol. 2001 May 01; 209(2):149-57. Ojo-Amaize EA, Kapahi P, Kakkanaiah VN, Takahashi T, Shalom-Barak T, Cottam HB, Adesomoju AA, Nchekwube EJ, Oyemade OA, Karin M, Okogun JI. PMID: 11446747.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    386. AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation. Mol Cell Biol. 2001 May; 21(9):3012-24. Piu F, Aronheim A, Katz S, Karin M. PMID: 11287607.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    387. AP-1 in cell proliferation and survival. Oncogene. 2001 Apr 30; 20(19):2390-400. Shaulian E, Karin M. PMID: 11402335.
      View in: PubMed   Mentions: 412     Fields:    Translation:AnimalsCells
    388. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001 Apr 05; 410(6829):710-4. Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. PMID: 11287960.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    389. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity. 2001 Mar; 14(3):217-30. Senftleben U, Li ZW, Baud V, Karin M. PMID: 11290332.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    390. Mammalian MAP kinase signalling cascades. Nature. 2001 Mar 01; 410(6824):37-40. Chang L, Karin M. PMID: 11242034.
      View in: PubMed   Mentions: 1325     Fields:    Translation:AnimalsCells
    391. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. J Exp Med. 2001 Feb 05; 193(3):317-28. Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. PMID: 11157052.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    392. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol Cell. 2001 Feb; 7(2):421-32. Cavalli V, Vilbois F, Corti M, Marcote MJ, Tamura K, Karin M, Arkinstall S, Gruenberg J. PMID: 11239470.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    393. Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway. Mol Endocrinol. 2001 Jan; 15(1):32-45. Feng W, Webb P, Nguyen P, Liu X, Li J, Karin M, Kushner PJ. PMID: 11145737.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    394. Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors. 2001; 15(2-4):87-9. Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. PMID: 12016332.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    395. ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem. 2001 Mar 23; 276(12):8898-903. Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. PMID: 11114307.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    396. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2000 Dec 08; 103(6):909-18. Chu W, Gong X, Li Z, Takabayashi K, Ouyang H, Chen Y, Lois A, Chen DJ, Li GC, Karin M, Raz E. PMID: 11136976.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    397. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell. 2000 Dec 08; 103(6):897-907. Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. PMID: 11136975.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    398. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17; 275(46):36062-6. Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. PMID: 10967126.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    399. IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3665-9. Yoshida K, Hu Y, Karin M. PMID: 11053261.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    400. Kinase regulation in inflammatory response. Nature. 2000 Jul 27; 406(6794):367-8. Delhase M, Li N, Karin M. PMID: 10935625.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    401. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21; 102(2):221-31. Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. PMID: 10943842.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    402. Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2. J Biol Chem. 2000 Jul 14; 275(28):21653-60. López-Fernández J, Palacios D, Castillo AI, Tolon RM, Aranda A, Karin M. PMID: 10801832.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    403. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell. 2000 Jul 07; 102(1):67-76. Spence J, Gali RR, Dittmar G, Sherman F, Karin M, Finley D. PMID: 10929714.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    404. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun; 5(6):969-79. Makris C, Godfrey VL, Krähn-Senftleben G, Takahashi T, Roberts JL, Schwarz T, Feng L, Johnson RS, Karin M. PMID: 10911991.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    405. p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol. 2000 Jun; 20(11):3951-64. Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL. PMID: 10805738.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    406. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 2000 May 15; 14(10):1236-48. Chen CY, Gherzi R, Andersen JS, Gaietta G, Jürchott K, Royer HD, Mann M, Karin M. PMID: 10817758.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    407. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5243-8. Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. PMID: 10805784.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    408. NAK is an IkappaB kinase-activating kinase. Nature. 2000 Apr 13; 404(6779):778-82. Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M. PMID: 10783893.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    409. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr; 20(7):2334-42. Cheng J, Yang J, Xia Y, Karin M, Su B. PMID: 10713157.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    410. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 2000 Mar 01; 14(5):574-84. Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. PMID: 10716945.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    411. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol. 2000 Feb; 12(1):85-98. Karin M, Delhase M. PMID: 10723801.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansAnimalsCells
    412. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000 Jan 06; 403(6765):103-8. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. PMID: 10638762.
      View in: PubMed   Mentions: 280     Fields:    Translation:HumansAnimalsCells
    413. Assays for JNK and p38 mitogen-activated protein kinases. Methods Enzymol. 2000; 322:388-92. Sudo T, Karin M. PMID: 10914034.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    414. Analysis and identification of protein-protein interactions using protein recruitment systems. Methods Enzymol. 2000; 328:47-59. Aronheim A, Karin M. PMID: 11075337.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    415. Signaling pathways leading to nuclear factor-kappa B activation. Methods Enzymol. 2000; 319:273-9. Li N, Karin M. PMID: 10907518.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    416. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol. 2000; 18:621-63. Karin M, Ben-Neriah Y. PMID: 10837071.
      View in: PubMed   Mentions: 1273     Fields:    Translation:HumansAnimalsCells
    417. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 1999 Dec; 11(6):721-31. Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. PMID: 10626894.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    418. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev. 1999 Dec; 89(1-2):115-24. Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. PMID: 10559486.
      View in: PubMed   Mentions: 108     Fields:    Translation:Animals
    419. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene. 1999 Nov 22; 18(49):6867-74. Karin M. PMID: 10602462.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimalsCells
    420. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999 Oct 26; 1999(5):RE1. Rothwarf DM, Karin M. PMID: 11865184.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    421. Stress-induced JNK activation is independent of Gadd45 induction. J Biol Chem. 1999 Oct 15; 274(42):29595-8. Shaulian E, Karin M. PMID: 10514425.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    422. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem. 1999 Sep 24; 274(39):27339-42. Karin M. PMID: 10488062.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    423. Is NF-kappaB the sensor of oxidative stress? FASEB J. 1999 Jul; 13(10):1137-43. Li N, Karin M. PMID: 10385605.
      View in: PubMed   Mentions: 174     Fields:    Translation:Humans
    424. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol. 1999 Jul; 19(7):4547-51. Zandi E, Karin M. PMID: 10373503.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    425. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 07; 189(11):1839-45. Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. PMID: 10359587.
      View in: PubMed   Mentions: 289     Fields:    Translation:AnimalsCells
    426. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). J Biol Chem. 1999 May 21; 274(21):15173-80. Tian J, Karin M. PMID: 10329725.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    427. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15; 13(10):1297-308. Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. PMID: 10346818.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    428. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science. 1999 Apr 09; 284(5412):316-20. Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. PMID: 10195896.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    429. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science. 1999 Apr 09; 284(5412):309-13. Delhase M, Hayakawa M, Chen Y, Karin M. PMID: 10195894.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansCells
    430. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 1999 Mar 01; 13(5):607-19. Schreiber M, Kolbus A, Piu F, Szabowski A, Möhle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF. PMID: 10072388.
      View in: PubMed   Mentions: 184     Fields:    Translation:AnimalsCells
    431. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol. 1999 Feb 11; 9(3):116-25. Sabapathy K, Hu Y, Kallunki T, Schreiber M, David JP, Jochum W, Wagner EF, Karin M. PMID: 10021384.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    432. An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med. 1999 Jan 04; 189(1):145-58. Hettmann T, DiDonato J, Karin M, Leiden JM. PMID: 9874571.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    433. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999 Jan; 19(1):751-63. Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. PMID: 9858598.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    434. The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. Cold Spring Harb Symp Quant Biol. 1999; 64:491-503. Delhase M, Karin M. PMID: 11232326.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    435. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 01; 12(21):3369-81. Xia Y, Wu Z, Su B, Murray B, Karin M. PMID: 9808624.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    436. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13012-7. Li N, Karin M. PMID: 9789032.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    437. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17; 395(6699):297-300. Rothwarf DM, Zandi E, Natoli G, Karin M. PMID: 9751060.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansCells
    438. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28; 281(5381):1360-3. Zandi E, Chen Y, Karin M. PMID: 9721103.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    439. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6. Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. PMID: 9694868.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    440. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9067-9. Karin M, Delhase M. PMID: 9689033.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    441. Multicellular stalk-like structures in Saccharomyces cerevisiae. J Bacteriol. 1998 Aug; 180(15):3992-6. Engelberg D, Mimran A, Martinetto H, Otto J, Simchen G, Karin M, Fink GR. PMID: 9683500.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    442. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998 Jul 15; 18(14):5124-35. Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. PMID: 9651196.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    443. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann N Y Acad Sci. 1998 Jun 30; 851:139-46. Karin M. PMID: 9668616.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    444. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science. 1998 Jun 19; 280(5371):1945-9. Chen CY, Del Gatto-Konczak F, Wu Z, Karin M. PMID: 9632395.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    445. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 1998 Jun 01; 17(11):3101-11. Werlen G, Jacinto E, Xia Y, Karin M. PMID: 9606192.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    446. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell. 1998 Jun; 9(6):1437-48. Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D. PMID: 9614185.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    447. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 1998 May 15; 93(4):487-90. Karin M. PMID: 9604923.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    448. The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. Cancer J Sci Am. 1998 May; 4 Suppl 1:S92-9. Karin M. PMID: 9619277.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    449. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 1998 Jan; 8(1):31-41. Jacinto E, Werlen G, Karin M. PMID: 9462509.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    450. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol Cell Biol. 1997 Dec; 17(12):7407-16. Wu Z, Wu J, Jacinto E, Karin M. PMID: 9372971.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    451. Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta. 1997 Oct 24; 1333(2):F85-104. Minden A, Karin M. PMID: 9395283.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    452. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17; 91(2):243-52. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. PMID: 9346241.
      View in: PubMed   Mentions: 434     Fields:    Translation:HumansCells
    453. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 07; 388(6642):548-54. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. PMID: 9252186.
      View in: PubMed   Mentions: 514     Fields:    Translation:HumansCells
    454. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol Cell Biol. 1997 Aug; 17(8):4687-95. Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. PMID: 9234725.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    455. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102. Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. PMID: 9154808.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    456. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997 Apr 10; 336(15):1066-71. Barnes PJ, Karin M. PMID: 9091804.
      View in: PubMed   Mentions: 1002     Fields:    Translation:HumansCells
    457. AP-1 function and regulation. Curr Opin Cell Biol. 1997 Apr; 9(2):240-6. Karin M, Liu Zg, Zandi E. PMID: 9069263.
      View in: PubMed   Mentions: 566     Fields:    Translation:HumansAnimals
    458. Immunoregulatory genes and immunosuppression by glucocorticoids. Arch Toxicol Suppl. 1997; 19:87-95. Auphan N, Didonato JA, Helmberg A, Rosette C, Karin M. PMID: 9079197.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    459. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29; 87(5):929-39. Kallunki T, Deng T, Hibi M, Karin M. PMID: 8945519.
      View in: PubMed   Mentions: 138     Fields:    Translation:Cells
    460. A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol. 1996 Nov 25; 180(1):353-64. Reach M, Galindo RL, Towb P, Allen JL, Karin M, Wasserman SA. PMID: 8948598.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    461. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 1996 Nov 21; 384(6606):273-6. Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M, Wang JY. PMID: 8918879.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    462. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 1996 Nov 15; 15(22):6269-79. Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M. PMID: 8947050.
      View in: PubMed   Mentions: