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Michael Karin

Title(s)Professor, Pharmacology
SchoolHealth Sciences
Address9500 Gilman Drive #0723
La Jolla CA 92093
Phone858-534-0872
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    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH/NIDDK R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH/NCI R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH/NIAAA U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH/NCI R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH/NIDDK P01DK098108Sep 1, 2014 - Jun 30, 2019
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH/NIAAA U01AA022614Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH/NCI R01CA163798Jul 16, 2012 - Apr 30, 2017
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH/NCI R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH/NCRR P41RR004050Aug 13, 2009 - Mar 31, 2014
    Role: Co-Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH/NCI R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH/NCI R01CA127923Apr 13, 2007 - Jul 31, 2011
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH/NCI R01CA118165Apr 1, 2007 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH/NIAID R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH/NIAID R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH/NCI R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH/NIAID R01AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH/NIAID R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH/NCI R01CA076188Feb 15, 1998 - Nov 30, 2001
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH/NCI P30CA023100Jul 1, 1996 - Sep 29, 2012
    Role: Co-Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH/NCI P01CA050528Feb 1, 1996 - Mar 31, 1997
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH/NIEHS R01ES006376Jun 1, 1993 - May 31, 2002
    Role: Principal Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH/NIDDK R01DK038527Jun 1, 1991 - May 31, 1995
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH/NHLBI R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH/NHLBI P01HL035018Jul 1, 1988 - Nov 30, 1996
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH/NIEHS R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 Aug 24. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596.
      View in: PubMed   Mentions:
    2. PKC?/? Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 Aug 10; 38(2):247-262.e11. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943.
      View in: PubMed   Mentions:    Fields:    
    3. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 Jun 17; 41(4):405-416. He F, Antonucci L, Karin M. PMID: 32347301.
      View in: PubMed   Mentions: 1     Fields:    
    4. Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 May 28; 18(1):214. Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781.
      View in: PubMed   Mentions: 1     Fields:    
    5. Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 Mar 04; 9(3). Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413.
      View in: PubMed   Mentions: 4     Fields:    
    6. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 Mar; 8(1). Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603.
      View in: PubMed   Mentions: 21     Fields:    
    7. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 Jun; 72(6):1182-1195. He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670.
      View in: PubMed   Mentions: 3     Fields:    
    8. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339.
      View in: PubMed   Mentions:    Fields:    
    9. Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 Apr 26; 38:649-671. Shalapour S, Karin M. PMID: 32040356.
      View in: PubMed   Mentions:    Fields:    
    10. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. NF-?B-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 Jul; 27(7):2206-2216. Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855.
      View in: PubMed   Mentions: 1     Fields:    
    12. A dual role for hepatocyte-intrinsic canonical NF-?B signaling in virus control. J Hepatol. 2020 May; 72(5):960-975. Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
      View in: PubMed   Mentions:    Fields:    
    13. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
      View in: PubMed   Mentions:    Fields:    
    14. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189. Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    15. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190. Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
      View in: PubMed   Mentions: 2     Fields:    
    17. Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-?B kinase subunit ß-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769. Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-?B Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312. Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566.
      View in: PubMed   Mentions: 2     Fields:    
    19. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 09 01; 79(17):4326-4330. Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. PMID: 31481419.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications. J Hepatol. 2020 01; 72(1):167-182. Hou J, Zhang H, Sun B, Karin M. PMID: 31449859.
      View in: PubMed   Mentions: 5     Fields:    
    21. Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. Immunity. 2019 07 16; 51(1):15-26. Shalapour S, Karin M. PMID: 31315033.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    22. The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 05 13; 35(5):714-720. Todoric J, Karin M. PMID: 31085174.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach. Mol Cancer Res. 2019 07; 17(7):1493-1502. Friemel J, Frick L, Unger K, Egger M, Parrotta R, Böge YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. PMID: 30967480.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003.
      View in: PubMed   Mentions: 1     Fields:    
    27. Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 01 08; 29(1):18-26. Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. PMID: 30449681.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    28. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    31. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714.
      View in: PubMed   Mentions:    Fields:    
    33. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    34. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    35. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    36. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    37. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 03; 25(3):486-541. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479.
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