Michael Karin

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
    NIH U54CA260591Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH U01AA022614Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH R01CA163798Jul 16, 2012 - Apr 30, 2018
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH R01CA127923Apr 13, 2007 - Feb 28, 2018
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH R01CA118165Dec 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Regulation of NF-kappaB and IKK by proinflammatory stimuli
    NIH R01AI043477Jul 1, 1998 - May 31, 2018
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH R01CA076188Feb 15, 1998 - Jul 31, 2007
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH R01DK038527Sep 1, 1987 - Apr 30, 1999
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance. Sci Adv. 2023 10 27; 9(43):eadg5391. Rundberg Nilsson AJS, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 37889967; PMCID: PMC10610924.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv. 2023 09 15; 9(37):eadh0831. Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. PMID: 37703359; PMCID: PMC10499313.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Multifaceted collagen-DDR1 signaling in cancer. Trends Cell Biol. 2023 Sep 12. Su H, Karin M. PMID: 37709651.
      View in: PubMed   Mentions:    Fields:    
    4. Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001. Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21. Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. PMID: 37502951; PMCID: PMC10370167.
      View in: PubMed   Mentions:
    6. Collagen architecture and signaling orchestrate cancer development. Trends Cancer. 2023 09; 9(9):764-773. Su H, Karin M. PMID: 37400314.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Author Correction: A central role for JNK in obesity and insulin resistance. Nature. 2023 Jul; 619(7968):E25. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 37328696.
      View in: PubMed   Mentions:    Fields:    
    8. Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023 Jun; 618(7966):808-817. Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. PMID: 37344645; PMCID: PMC10284692.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651. Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. PMID: 37156770; PMCID: PMC10167314.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2300706120. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 37126700; PMCID: PMC10175751.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154. Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. PMID: 37100955; PMCID: PMC10130819.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    12. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2023 05 01; 77(5):1499-1511. Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C, Li Y, Prochownik EV, Karin M, Wang F, Li Y. PMID: 35398929.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    14. Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genom. 2023 May 10; 3(5):100301. Carlessi R, Denisenko E, Boslem E, Köhn-Gaone J, Main N, Abu Bakar NDB, Shirolkar GD, Jones M, Beasley AB, Poppe D, Dwyer BJ, Jackaman C, Tjiam MC, Lister R, Karin M, Fallowfield JA, Kendall TJ, Forbes SJ, Gray ES, Olynyk JK, Yeoh G, Forrest ARR, Ramm GA, Febbraio MA, Tirnitz-Parker JEE. PMID: 37228755; PMCID: PMC10203275.
      View in: PubMed   Mentions: 2  
    15. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023 08; 79(2):362-377. He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. PMID: 36996941.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    16. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. bioRxiv. 2023 Mar 06. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang J, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 36945365; PMCID: PMC10028807.
      View in: PubMed   Mentions:
    17. IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance. bioRxiv. 2023 Mar 02. Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 36747722; PMCID: PMC9900858.
      View in: PubMed   Mentions:
    18. Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
      View in: PubMed   Mentions: 1     Fields:    
    19. Oxidized mitochondrial DNA: a protective signal gone awry. Trends Immunol. 2023 03; 44(3):188-200. Xian H, Karin M. PMID: 36739208.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022 11 15; 13(11):959. Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. PMID: 36379916; PMCID: PMC9666555.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature. 2022 10; 610(7931):356-365. Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF. PMID: 36198802; PMCID: PMC9949942.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    22. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    23. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    24. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Semin Liver Dis. 2022 08; 42(3):233-249. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. PMID: 36001995; PMCID: PMC9662188.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5. Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    26. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    27. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    28. Diabesity? No worries, FKBP11 to the rescue. Cell Metab. 2022 07 05; 34(7):942-944. Karin M. PMID: 35793657.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    29. NF-κB: A Double-Edged Sword Controlling Inflammation. Biomedicines. 2022 May 27; 10(6). Liu D, Zhong Z, Karin M. PMID: 35740272; PMCID: PMC9219609.
      View in: PubMed   Mentions: 11  
    30. Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth. Cell Death Discov. 2022 Mar 03; 8(1):94. De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. PMID: 35241649; PMCID: PMC8894496.
      View in: PubMed   Mentions: 2  
    31. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    32. IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. PMID: 35121655; PMCID: PMC8833198.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172. Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    34. "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab. 2021 12 07; 33(12):2316-2328. Febbraio MA, Karin M. PMID: 34619076; PMCID: PMC8665123.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    35. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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