Michael Karin

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
    NIH U54CA260591Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH U01AA022614Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH R01CA163798Jul 16, 2012 - Apr 30, 2018
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH R01CA127923Apr 13, 2007 - Feb 28, 2018
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH R01CA118165Dec 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Regulation of NF-kappaB and IKK by proinflammatory stimuli
    NIH R01AI043477Jul 1, 1998 - May 31, 2018
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH R01CA076188Feb 15, 1998 - Jul 31, 2007
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH R01DK038527Sep 1, 1987 - Apr 30, 1999
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 Jul 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 Jul 07. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107.
      View in: PubMed   Mentions:    Fields:    
    3. Diabesity? No worries, FKBP11 to the rescue. Cell Metab. 2022 Jul 05; 34(7):942-944. Karin M. PMID: 35793657.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. NF-κB: A Double-Edged Sword Controlling Inflammation. Biomedicines. 2022 May 27; 10(6). Liu D, Zhong Z, Karin M. PMID: 35740272; PMCID: PMC9219609.
      View in: PubMed   Mentions:
    5. P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2022 Apr 10. Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C, Li Y, Prochownik EV, Karin M, Wang F, Li Y. PMID: 35398929.
      View in: PubMed   Mentions:    Fields:    
    6. Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth. Cell Death Discov. 2022 Mar 03; 8(1):94. De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. PMID: 35241649; PMCID: PMC8894496.
      View in: PubMed   Mentions:
    7. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. PMID: 35121655; PMCID: PMC8833198.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172. Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab. 2021 12 07; 33(12):2316-2328. Febbraio MA, Karin M. PMID: 34619076; PMCID: PMC8665123.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Regulation of antitumor immunity by inflammation-induced epigenetic alterations. Cell Mol Immunol. 2022 01; 19(1):59-66. Karin M, Shalapour S. PMID: 34465885; PMCID: PMC8752743.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. The neglected brothers come of age: B cells and cancer. Semin Immunol. 2021 02; 52:101479. Shalapour S, Karin M. PMID: 34215491; PMCID: PMC8545794.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 09; 191(9):1564-1579. Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. PMID: 34119473; PMCID: PMC8406794.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11. Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    16. Macropinocytosis: the big drinker behind cancer cell self-consumption. Autophagy. 2021 05; 17(5):1290-1291. Su H, Yang F, Sun B, Karin M. PMID: 33879021; PMCID: PMC8143249.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. PMID: 33833060; PMCID: PMC8054017.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    18. Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis. Cancers (Basel). 2021 Mar 25; 13(7). Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Karin M, Itoh Y. PMID: 33806040; PMCID: PMC8037653.
      View in: PubMed   Mentions: 3  
    19. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 05 10; 39(5):678-693.e11. Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. PMID: 33740421; PMCID: PMC8119368.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. From Liver Fat to Cancer: Perils of the Western Diet. Cancers (Basel). 2021 Mar 04; 13(5). Kim JY, He F, Karin M. PMID: 33806428; PMCID: PMC7961422.
      View in: PubMed   Mentions: 2  
    21. Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, Cheng Z, Haybaeck J, Kenner L, Fisch KM, Bourgon R, Hernandez G, Lill JR, Liu S, Carter H, Mellman I, Karin M, Shalapour S. PMID: 33602823; PMCID: PMC7923353.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. BMJ Open. 2021 02 12; 11(2):e043584. Ebinger JE, Botwin GJ, Albert CM, Alotaibi M, Arditi M, Berg AH, Binek A, Botting P, Fert-Bober J, Figueiredo JC, Grein JD, Hasan W, Henglin M, Hussain SK, Jain M, Joung S, Karin M, Kim EH, Li D, Liu Y, Luong E, McGovern DPB, Merchant A, Merin N, Miles PB, Minissian M, Nguyen TT, Raedschelders K, Rashid MA, Riera CE, Riggs RV, Sharma S, Sternbach S, Sun N, Tourtellotte WG, Van Eyk JE, Sobhani K, Braun JG, Cheng S. PMID: 33579769; PMCID: PMC7883610.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    23. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021 06; 74(6):1429-1441. Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC. PMID: 33515644; PMCID: PMC8573791.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 05; 18(5):261-279. Hou J, Karin M, Sun B. PMID: 33469195; PMCID: PMC8978805.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    25. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31259-31266. Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553; PMCID: PMC7733785.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    26. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    27. PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 08 10; 38(2):247-262.e11. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943; PMCID: PMC7423690.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    28. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 06 17; 41(4):405-416. He F, Antonucci L, Karin M. PMID: 32347301; PMCID: PMC7298623.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    29. Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214. Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781; PMCID: PMC7257145.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    30. Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 03 04; 9(3). Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413; PMCID: PMC7140520.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    31. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 03; 8(1). Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603; PMCID: PMC7064135.
      View in: PubMed   Mentions: 186     Fields:    Translation:Humans
    32. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 06; 72(6):1182-1195. He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670; PMCID: PMC8054878.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 04 26; 38:649-671. Shalapour S, Karin M. PMID: 32040356; PMCID: PMC8936002.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    35. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622; PMCID: PMC8012106.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    36. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 07; 27(7):2206-2216. Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855; PMCID: PMC7308363.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    37. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 2020 05; 72(5):960-975. Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
      View in: PubMed   Mentions:    Fields:    
    39. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189. Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511; PMCID: PMC6955241.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    40. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190. Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512; PMCID: PMC6955242.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
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    623. Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature. 1986 Oct 9-15; 323(6088):555-8. Imbra RJ, Karin M. PMID: 3020435.
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    624. Structure and tissue-specific expression of the human metallothionein IB gene. Mol Cell Biol. 1986 Jun; 6(6):2149-57. Heguy A, West A, Richards RI, Karin M. PMID: 3785191; PMCID: PMC367755.
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    625. In vivo competition between a metallothionein regulatory element and the SV40 enhancer. Science. 1986 Apr 04; 232(4746):76-80. Scholer H, Haslinger A, Heguy A, Holtgreve H, Karin M. PMID: 3006253.
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    626. Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8572-6. Haslinger A, Karin M. PMID: 3866241; PMCID: PMC390959.
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    627. Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene. Mol Cell Biol. 1985 Nov; 5(11):2984-92. Slater EP, Rabenau O, Karin M, Baxter JD, Beato M. PMID: 3018491; PMCID: PMC369110.
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    630. Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia. Nature. 1985 Feb 21-27; 313(6004):709-11. Le Beau MM, Diaz MO, Karin M, Rowley JD. PMID: 3856101.
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    631. Tissue-specific influences affect glucocorticoid regulatory element actions on the human growth hormone gene promotor. Trans Assoc Am Physicians. 1985; 98:66-73. Slater EP, Anderson TR, Cattini PA, Eberhardt NL, Karin M, Mellon PL, Baxter JD. PMID: 3842208.
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    632. Nucleotide sequence requirements for transient expression of human metallothionein-IIA-thymidine kinase fusion genes. DNA. 1984 Aug; 3(4):319-26. Karin M, Holtgreve H. PMID: 6489094.
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    637. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):337-41. Karin M, Najarian R, Haslinger A, Valenzuela P, Welch J, Fogel S. PMID: 6364141; PMCID: PMC344671.
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    639. Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells. DNA. 1984; 3(2):147-55. Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G. PMID: 6723496.
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    640. Gene amplification in yeast: CUP1 copy number regulates copper resistance. Curr Genet. 1983 Sep; 7(5):347-55. Fogel S, Welch JW, Cathala G, Karin M. PMID: 24173415.
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    642. Expression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4040-4. Karin M, Cathala G, Nguyen-Huu MC. PMID: 6306660; PMCID: PMC394196.
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    643. A method for isolation of intact, translationally active ribonucleic acid. DNA. 1983; 2(4):329-35. Cathala G, Savouret JF, Mendez B, West BL, Karin M, Martial JA, Baxter JD. PMID: 6198133.
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    644. Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature. 1982 Oct 28; 299(5886):797-802. Karin M, Richards RI. PMID: 7133118.
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    645. Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. Nucleic Acids Res. 1982 May 25; 10(10):3165-73. Karin M, Richards RI. PMID: 6896577; PMCID: PMC320698.
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    646. Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. Eur J Biochem. 1981 Sep 01; 118(3):527-31. Karin M, Andersen RD, Herschman HR. PMID: 7297561.
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    649. Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature. 1980 Jul 17; 286(5770):295-7. Karin M, Andersen RD, Slater E, Smith K, Herschman HR. PMID: 7402316.
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    650. Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc. Eur J Biochem. 1980 Jun; 107(2):395-401. Karin M, Herschman HR. PMID: 7398649.
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    651. Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells. J Cell Physiol. 1980 Apr; 103(1):35-40. Karin M, Herschman HR. PMID: 7430258.
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    652. Primary induction of metallothionein by dexamethasone in culture rat hepatocytes. Biochem Biophys Res Commun. 1980 Feb 12; 92(3):1052-69. Karin M, Herschman HR, Weinstein D. PMID: 7362599.
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