Michael Karin
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Title(s) | Professor, Pharmacology |
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School | Health Sciences |
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Address | 9500 Gilman Drive #0723 La Jolla CA 92093
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Phone | 858-534-0872 |
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vCard | Download vCard |
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Biography Tel Aviv University, Tel Aviv, Israel | B.Sc. | | Biology | University of California, Los Angeles, Los Angeles, CA | Ph.D. | | Molecular Biology | Fox Chase Institute for Cancer Research, Philadelphia, PA | Postdoctoral Scholar | | Molecular Biology | University of California, San Francisco, San Francisco, CA | Postdoctoral Scholar | | Biochemistry |
Overview Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.
Research ORNG Applications Bibliographic
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Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. BMJ Open. 2021 02 12; 11(2):e043584.
PMID: 33579769.
View in: PubMed Mentions: Fields:
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Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 Jan 19.
Hou J, Karin M, Sun B. PMID: 33469195.
View in: PubMed Mentions: Fields:
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Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 Nov 23.
Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045.
Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596.
View in: PubMed Mentions:
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PKC?/? Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 Aug 10; 38(2):247-262.e11.
Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943.
View in: PubMed Mentions: 4 Fields:
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NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 06 17; 41(4):405-416.
He F, Antonucci L, Karin M. PMID: 32347301.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimals
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Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214.
Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781.
View in: PubMed Mentions: 1 Fields:
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Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 03 04; 9(3).
Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413.
View in: PubMed Mentions: 11 Fields:
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 Mar; 8(1).
Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603.
View in: PubMed Mentions: 39 Fields:
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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 Jun; 72(6):1182-1195.
He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670.
View in: PubMed Mentions: 6 Fields:
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Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3).
Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339.
View in: PubMed Mentions: 2 Fields:
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Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 04 26; 38:649-671.
Shalapour S, Karin M. PMID: 32040356.
View in: PubMed Mentions: 2 Fields:
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An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660.
Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 Jul; 27(7):2206-2216.
Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855.
View in: PubMed Mentions: 3 Fields:
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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 2020 05; 72(5):960-975.
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
View in: PubMed Mentions: Fields:
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Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136.
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
View in: PubMed Mentions: Fields:
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Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189.
Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190.
Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May; 72(5):946-959.
Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206.
View in: PubMed Mentions: 5 Fields:
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Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-?B kinase subunit ß-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769.
Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312.
Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566.
View in: PubMed Mentions: 3 Fields:
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Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 09 01; 79(17):4326-4330.
Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. PMID: 31481419.
View in: PubMed Mentions: 13 Fields: Translation: Humans
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The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications. J Hepatol. 2020 01; 72(1):167-182.
Hou J, Zhang H, Sun B, Karin M. PMID: 31449859.
View in: PubMed Mentions: 13 Fields:
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Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. Immunity. 2019 07 16; 51(1):15-26.
Shalapour S, Karin M. PMID: 31315033.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimals
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The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 05 13; 35(5):714-720.
Todoric J, Karin M. PMID: 31085174.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimals
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Choline Uptake and Metabolism Modulate Macrophage IL-1ß and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7.
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimalsCells
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Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach. Mol Cancer Res. 2019 07; 17(7):1493-1502.
Friemel J, Frick L, Unger K, Egger M, Parrotta R, Böge YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. PMID: 30967480.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470.
Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461.
View in: PubMed Mentions: 7 Fields: Translation: HumansCells
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Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785.
Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003.
View in: PubMed Mentions: 3 Fields:
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Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 01 08; 29(1):18-26.
Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. PMID: 30449681.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimals
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NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimalsCells
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Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888.
Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485.
View in: PubMed Mentions: 12 Fields: Translation: HumansAnimalsCells
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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15.
Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200.
Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212.
View in: PubMed Mentions: 13 Fields: Translation: HumansAnimalsCells
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Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714.
View in: PubMed Mentions: Fields:
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203.
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112.
View in: PubMed Mentions: 104 Fields: Translation: AnimalsCells
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The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411.
Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586.
View in: PubMed Mentions: 80 Fields: Translation: Humans
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6.
Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic ß-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88.
Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 03; 25(3):486-541.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479.
View in: PubMed Mentions: 490 Fields: Translation: HumansAnimalsCells
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NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 05; 18(5):309-324.
Taniguchi K, Karin M. PMID: 29379212.
View in: PubMed Mentions: 225 Fields: Translation: HumansAnimalsCells
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IKKa inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E812-E821.
Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. PMID: 29311298.
View in: PubMed Mentions: 10 Fields: Translation: HumansAnimals
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Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501.
View in: PubMed Mentions: Fields:
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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8.
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. PMID: 29153842.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345.
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460.
View in: PubMed Mentions: 64 Fields: Translation: HumansAnimalsCells
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Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1. PLoS One. 2017; 12(8):e0181052.
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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IKKß inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 2017 10; 60(10):2021-2032.
Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. PMID: 28725915.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 2017 Jul 19; 18(8):861-869.
Afonina IS, Zhong Z, Karin M, Beyaert R. PMID: 28722711.
View in: PubMed Mentions: 79 Fields: Translation: HumansCells
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DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7414-7419.
Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. PMID: 28652331.
View in: PubMed Mentions: 61 Fields: Translation: HumansCells
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GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 05; 24(5):929-943.
Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. PMID: 28387757.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440.
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773.
View in: PubMed Mentions: 6 Fields: Translation: HumansAnimalsCells
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YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648.
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I kappa B kinase alpha (IKKa) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20; 32(6):816-28.
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JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82.
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Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975.
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p38a inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24.
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Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3.
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Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 04; 288(1):598-607.
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Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8.
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Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21.
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Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21.
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Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95.
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Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12.
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Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93.
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The pore-forming toxin ß hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812.
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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
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CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2.
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IKKa-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77.
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I?B kinase ß (IKKß) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J. 2012 Mar 15; 442(3):723-32.
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Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4.
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NF-κB and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400.
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TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):E177-86.
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IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84.
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An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47.
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Obesity, inflammation, and liver cancer. J Hepatol. 2012 Mar; 56(3):704-13.
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Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507.
Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. PMID: 22389871.
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Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77.
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Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2.
Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082.
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Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84.
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. PMID: 21962514.
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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011 Sep; 134(Pt 9):2722-35.
Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. PMID: 21908876.
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Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14.
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Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900.
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Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13710-5.
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Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011 Jul 19; 12(8):715-23.
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Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44.
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Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 2011 Jun 14; 19(6):740-53.
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Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011 Jun 10; 11(7):457-68.
Häcker H, Tseng PH, Karin M. PMID: 21660053.
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JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12.
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IKK-ß-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 2011 May; 41(5):1266-77.
Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. PMID: 21469085.
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The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 2011 Apr 12; 19(4):429-31.
Li N, Grivennikov SI, Karin M. PMID: 21481782.
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Crystal structure of inhibitor of ?B kinase ß. Nature. 2011 Apr 21; 472(7343):325-30.
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. PMID: 21423167.
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Transcriptional regulation of the Th17 immune response by IKK(alpha). J Exp Med. 2011 Apr 11; 208(4):787-96.
Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. PMID: 21402739.
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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i104-8.
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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53.
Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. PMID: 21326202.
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Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011 Jan; 1217:191-206.
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IKKß regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318.
Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. PMID: 21587235.
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NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011 Jan; 21(1):159-68.
He G, Karin M. PMID: 21187858.
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Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13.
Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249.
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IL-1ß-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKß. Nat Immunol. 2011 Feb; 12(2):144-50.
Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. PMID: 21170027.
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JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7.
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Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. . 2010 Dec 08; 10(12):5088-92.
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B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60.
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Peering into the aftermath: JAKi rips STAT3 in cancer. Nat Med. 2010 Oct; 16(10):1085-7.
Greten FR, Karin M. PMID: 20930749.
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Stressin' Sestrins take an aging fight. EMBO Mol Med. 2010 Oct; 2(10):388-400.
Budanov AV, Lee JH, Karin M. PMID: 20878915.
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Sphingolipids: the oil on the TRAFire that promotes inflammation. Sci Signal. 2010 Sep 28; 3(141):pe34.
Napolitano G, Karin M. PMID: 20876871.
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Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75.
Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. PMID: 20841473.
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Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010 Sep 24; 33(3):400-11.
Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, Lebon P, Rozenberg F, Karin M, Tardieu M, Al-Muhsen S, Jouanguy E, Zhang SY, Abel L, Casanova JL. PMID: 20832341.
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Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27; 39(4):570-82.
Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. PMID: 20797629.
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Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest. 2010 Jul; 120(7):2563-74.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. PMID: 20530876.
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Inflammation and colon cancer. Gastroenterology. 2010 Jun; 138(6):2101-2114.e5.
Terzic J, Grivennikov S, Karin E, Karin M. PMID: 20420949.
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Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74.
Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249.
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Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12.
Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. PMID: 20494824.
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Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51.
Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472.
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JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010 Aug; 24(8):2596-611.
Solinas G, Karin M. PMID: 20371626.
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Immunity, inflammation, and cancer. Cell. 2010 Mar 19; 140(6):883-99.
Grivennikov SI, Greten FR, Karin M. PMID: 20303878.
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Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97.
He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. PMID: 20227042.
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B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010 Mar 11; 464(7286):302-5.
Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. PMID: 20220849.
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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8.
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043.
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NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-15.
Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. PMID: 20097762.
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Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010 Jan 22; 140(2):197-208.
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. PMID: 20141834.
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Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97.
Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. PMID: 20129250.
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Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010 Feb; 20(1):65-71.
Grivennikov SI, Karin M. PMID: 20036794.
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Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010 Feb; 21(1):11-9.
Grivennikov SI, Karin M. PMID: 20018552.
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Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J Immunol. 2009 Dec 15; 183(12):7877-89.
Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. PMID: 20007573.
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Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 2010 Mar; 138(3):1022-34.e1-10.
Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. PMID: 19962981.
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Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology. 2009 Dec; 50(6):1851-60.
Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. PMID: 19821485.
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Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50.
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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan; 11(1):70-5.
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. PMID: 19898473.
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NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a000141.
Karin M. PMID: 20066113.
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A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 06; 16(4):295-308.
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Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009 Nov 12; 114(20):4469-76.
Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. PMID: 19755673.
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MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol. 2009 Sep 15; 183(6):3831-8.
Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. PMID: 19710465.
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The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009 Aug 19; 4(8):e6695.
Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. PMID: 19690611.
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NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8.
Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630.
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Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5.
Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784.
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TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev. 2009 Mar; 228(1):225-40.
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Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565.
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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13.
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Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54.
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Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733.
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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009 Jan 01; 457(7225):102-6.
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Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009 Jan; 8(1):33-40.
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Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20197-202.
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Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71.
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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec; 9(12):1364-70.
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The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17091-6.
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NF-kappaB signaling, liver disease and hepatoprotective agents. Oncogene. 2008 Oct 20; 27(48):6228-44.
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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13.
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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008 Oct 03; 135(1):61-73.
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Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35.
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Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain. 2008 Nov; 131(Pt 11):3019-33.
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IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J. 2008 Oct 22; 27(20):2639-47.
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Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63.
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Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65.
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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 08; 134(3):451-60.
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Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One. 2008 Jul 23; 3(7):e2769.
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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008 Aug 01; 321(5889):663-8.
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IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9.
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Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008 Oct; 135(4):1311-21.
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The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 2008 Jul 08; 14(1):10-21.
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c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008 Jul 01; 68(13):5031-9.
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Prion propagation in mice lacking central nervous system NF-kappaB signalling. J Gen Virol. 2008 Jun; 89(Pt 6):1545-1550.
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A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8.
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An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76.
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NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 2008 Feb; 18(1):19-26.
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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11.
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The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 2008 Mar; 18(3):334-42.
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Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell. 2008 Feb 15; 29(3):279-90.
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IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2487-92.
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The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008 Mar; 14(3):109-19.
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Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell. 2008 Jan; 13(1):7-9.
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From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec; 220:8-21.
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JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97.
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Rsk Tolls the bell for endocytosis in DCs. Nat Immunol. 2007 Nov; 8(11):1197-9.
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Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90.
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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15852-7.
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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31.
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Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res. 2007 Sep 01; 13(17):4956-9.
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Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 Jul 06; 317(5834):121-4.
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A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May; 117(5):1175-83.
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Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6359-64.
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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901.
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Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4.
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Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007 Mar 29; 446(7135):552-6.
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p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60.
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NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1913-8.
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Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 2007; 602:125-34.
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Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos. 2007 Mar; 35(3):402-9.
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Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007 Jan; 8(1):57-63.
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Role for IKK2 in muscle: waste not, want not. J Clin Invest. 2006 Nov; 116(11):2866-8.
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Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 01; 177(9):6344-52.
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Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16454-9.
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Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17; 2006(357):re13.
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BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10.
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Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem. 2006 Dec 01; 281(48):37142-9.
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Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15.
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MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. Eur J Immunol. 2006 Aug; 36(8):2076-84.
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A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007 Feb 08; 26(6):851-8.
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Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20.
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Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 06; 442(7098):39-44.
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Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6.
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Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10544-51.
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NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun; 45(6):355-61.
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Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25; 441(7092):431-6.
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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-68.
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Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006 Apr; 116(4):1117-26.
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Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35.
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The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2292-7.
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Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9.
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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1717-22.
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Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lect. 2006-2007; 102:133-51.
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p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005 Dec 22; 20(6):891-903.
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Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 2005 Dec; 5(12):941-52.
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Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8.
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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7.
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The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005 Nov; 25(6):541-50.
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IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis. 2005 Nov; 64 Suppl 4:iv81-5.
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NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005 Oct; 5(10):749-59.
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Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell. 2005 Sep 02; 19(5):581-93.
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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29.
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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90.
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Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol. 2004 Jul; 41(6-7):701-14.
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A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell. 2004 Jun 04; 14(5):571-83.
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IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4.
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Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003 May; 51(5):555-65.
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Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17; 275(46):36062-6.
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IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3665-9.
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Kinase regulation in inflammatory response. Nature. 2000 Jul 27; 406(6794):367-8.
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Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21; 102(2):221-31.
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Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2. J Biol Chem. 2000 Jul 14; 275(28):21653-60.
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Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain. Cell. 2000 Jul 07; 102(1):67-76.
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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun; 5(6):969-79.
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p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol. 2000 Jun; 20(11):3951-64.
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Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes Dev. 2000 May 15; 14(10):1236-48.
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5243-8.
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NAK is an IkappaB kinase-activating kinase. Nature. 2000 Apr 13; 404(6779):778-82.
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Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Mol Cell Biol. 2000 Apr; 20(7):2334-42.
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Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev. 2000 Mar 01; 14(5):574-84.
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The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin Immunol. 2000 Feb; 12(1):85-98.
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Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 2000 Jan 06; 403(6765):103-8.
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Analysis and identification of protein-protein interactions using protein recruitment systems. Methods Enzymol. 2000; 328:47-59.
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Signaling pathways leading to nuclear factor-kappa B activation. Methods Enzymol. 2000; 319:273-9.
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JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 1999 Dec; 11(6):721-31.
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Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev. 1999 Dec; 89(1-2):115-24.
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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene. 1999 Nov 22; 18(49):6867-74.
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The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE. 1999 Oct 26; 1999(5):RE1.
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Is NF-kappaB the sensor of oxidative stress? FASEB J. 1999 Jul; 13(10):1137-43.
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Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol. 1999 Jul; 19(7):4547-51.
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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med. 1999 Jun 07; 189(11):1839-45.
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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 May 15; 13(10):1297-308.
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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science. 1999 Apr 09; 284(5412):316-20.
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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol. 1999 Feb 11; 9(3):116-25.
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An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. J Exp Med. 1999 Jan 04; 189(1):145-58.
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Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol. 1999 Jan; 19(1):751-63.
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The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. Cold Spring Harb Symp Quant Biol. 1999; 64:491-503.
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 01; 12(21):3369-81.
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Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13012-7.
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NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6.
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JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9067-9.
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Multicellular stalk-like structures in Saccharomyces cerevisiae. J Bacteriol. 1998 Aug; 180(15):3992-6.
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Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. J Neurosci. 1998 Jul 15; 18(14):5124-35.
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Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science. 1998 Jun 19; 280(5371):1945-9.
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A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol Biol Cell. 1998 Jun; 9(6):1437-48.
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New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 1998 May 15; 93(4):487-90.
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The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival. Cancer J Sci Am. 1998 May; 4 Suppl 1:S92-9.
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Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 1998 Jan; 8(1):31-41.
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Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Mol Cell Biol. 1997 Dec; 17(12):7407-16.
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Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta. 1997 Oct 24; 1333(2):F85-104.
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Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102.
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Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997 Apr 10; 336(15):1066-71.
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Immunoregulatory genes and immunosuppression by glucocorticoids. Arch Toxicol Suppl. 1997; 19:87-95.
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c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 1996 Nov 29; 87(5):929-39.
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A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol. 1996 Nov 25; 180(1):353-64.
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Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 1996 Nov 21; 384(6606):273-6.
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The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J. 1996 Nov 15; 15(22):6269-79.
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