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    Michael Karin

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0723
    CA La Jolla 92093
    Phone858-534-0872
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of California, Los Angeles

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Role of p62/SQSTM1 in obesity-induced liver cancer
      NIH/NCI R01CA211794Feb 15, 2017 - Jan 31, 2022
      Role: Principal Investigator
      Organelle Disorders in Pancreatitis
      NIH P01DK098108Sep 1, 2014 - Jun 30, 2019
      Role: Co-Investigator
      The Role of IL-17 in Alcoholic Liver Disease and Cancer
      NIH/NIAAA U01AA022614Sep 1, 2014 - Jun 30, 2019
      Role: Principal Investigator
      IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
      NIH/NCI R01CA163798Jul 16, 2012 - Apr 30, 2017
      Role: Principal Investigator
      TOR signaling and autophagy in obesity-promoted liver tumorigenesis
      NIH/NCI R01CA155120Jul 22, 2011 - May 31, 2016
      Role: Principal Investigator
      Pulmonary inflammation and lung cancer development and progression
      NIH/NCI R01CA132586May 5, 2008 - Apr 30, 2014
      Role: Principal Investigator
      IKK and the Control of Prostate Cancer Metastasis
      NIH/NCI R01CA127923Apr 13, 2007 - Feb 28, 2018
      Role: Principal Investigator
      Role of Inflammation in tumor promotion and progression
      NIH/NCI R01CA118165Dec 1, 2005 - Mar 31, 2017
      Role: Principal Investigator
      How Anthrax lethal factor kills macrophages
      NIH/NIAID R01AI061712Jun 1, 2004 - May 31, 2010
      Role: Principal Investigator
      How Anthrax lethal factor kills activated macrophages
      NIH/NIAID R21AI053528Sep 15, 2002 - Aug 31, 2005
      Role: Principal Investigator
      DETECTION AND MODELS OF TOXICANT EXPOSURE
      NIH/NIEHS P42ES010337Jul 1, 2000 - Mar 31, 2022
      Role: Co-Investigator
      NF KAPPA B REGULATION AND FUNCTION
      NIH/NCI R13CA086394Mar 14, 2000 - Mar 13, 2001
      Role: Principal Investigator
      Regulation of NF-kappaB and IKK by proinflammatory stimuli
      NIH/NIAID R01AI043477Jul 1, 1998 - May 31, 2018
      Role: Principal Investigator
      Functions and Mechanisms of Radiation Induced Responses
      NIH/NCI R01CA076188Feb 15, 1998 - Jul 31, 2007
      Role: Principal Investigator
      Stress Signaling Pathways in Toxicity and Disease
      NIH/NIEHS R01ES006376Jun 1, 1993 - Jul 31, 2013
      Role: Principal Investigator
      FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
      NIH/NHLBI R13HL046015Jul 1, 1990 - Jun 30, 1991
      Role: Principal Investigator
      FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
      NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
      NIH/NIDDK R01DK038527Sep 1, 1987 - Apr 30, 1999
      Role: Principal Investigator
      GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
      NIH/NHLBI P01HL035018Mar 1, 1986 - Dec 31, 2009
      Role: Co-Investigator
      INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
      NIH/NIEHS R37ES004151Jan 1, 1986 - Mar 31, 2009
      Role: Principal Investigator
      INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
      NIH/NIEHS R01ES004151Jan 1, 1986 - Mar 31, 1998
      Role: Principal Investigator
      INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
      NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
      Role: Co-Investigator
      INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
      NIH/NIEHS R01ES003222Jul 1, 1983 - Dec 31, 1985
      Role: Principal Investigator
      Specialized Cancer Center Support Grant
      NIH/NCI P30CA023100Apr 1, 1978 - Apr 30, 2019
      Role: Co-Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 Nov 16; 551(7680):340-345. PMID: 29144460.
        View in: PubMed
      2. Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):7414-7419. PMID: 28652331.
        View in: PubMed
      3. Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 May; 24(5):929-943. PMID: 28387757.
        View in: PubMed
      4. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. PMID: 28167773.
        View in: PubMed
      5. Todoric J, Antonucci L, Karin M. Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prev Res (Phila). 2016 Dec; 9(12):895-905. PMID: 27913448.
        View in: PubMed
      6. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PI3K? is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. PMID: 27642729.
        View in: PubMed
      7. Taniguchi K, Yamachika S, He F, Karin M. p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 2016 Aug; 590(15):2375-97. PMID: 27404485; PMCID: PMC4983218 [Available on 08/06/17].
        View in: PubMed, PubMed Central
      8. Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6. PMID: 27586797.
        View in: PubMed
      9. Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298. PMID: 27419869; PMCID: PMC4947210 [Available on 07/14/17].
        View in: PubMed, PubMed Central
      10. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. PMID: 27211490; PMCID: PMC4907799 [Available on 06/13/17].
        View in: PubMed, PubMed Central
      11. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 May 17; 7:11551. PMID: 27187615; PMCID: PMC4873670.
        View in: PubMed, PubMed Central
      12. Shalapour S, Karin M. Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. Cell Metab. 2016 May 10; 23(5):759-61. PMID: 27166937.
        View in: PubMed
      13. Karin M, Dhar D. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis. 2016 06; 37(6):541-6. PMID: 27207669; PMCID: PMC4876993 [Available on 06/01/17].
        View in: PubMed, PubMed Central
      14. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. PMID: 26919428; PMCID: PMC4769378 [Available on 02/25/17].
        View in: PubMed, PubMed Central
      15. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
        View in: PubMed
      16. Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 2016 Jan 21; 529(7586):307-15. PMID: 26791721.
        View in: PubMed
      17. Font-Burgada J, Sun B, Karin M. Obesity and Cancer: The Oil that Feeds the Flame. Cell Metab. 2016 Jan 12; 23(1):48-62. PMID: 26771116.
        View in: PubMed
      18. Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5. PMID: 26554006; PMCID: PMC4664371.
        View in: PubMed, PubMed Central
      19. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6166-74. PMID: 26512112; PMCID: PMC4653219.
        View in: PubMed, PubMed Central
      20. Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44. PMID: 26502405; PMCID: PMC4653079.
        View in: PubMed, PubMed Central
      21. Wang K, Karin M. The IL-23 to IL-17 cascade inflammation-related cancers. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S87-90. PMID: 26457610.
        View in: PubMed
      22. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. PMID: 26276631; PMCID: PMC4545590.
        View in: PubMed, PubMed Central
      23. Strasner A, Karin M. Immune Infiltration and Prostate Cancer. Front Oncol. 2015; 5:128. PMID: 26217583; PMCID: PMC4495337.
        View in: PubMed, PubMed Central
      24. Wu X, Karin M. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 Jul; 266(1):161-74. PMID: 26085214.
        View in: PubMed
      25. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. PMID: 26109050; PMCID: PMC4495398.
        View in: PubMed, PubMed Central
      26. Wang K, Karin M. Tumor-Elicited Inflammation and Colorectal Cancer. Adv Cancer Res. 2015; 128:173-96. PMID: 26216633.
        View in: PubMed
      27. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. PMID: 25924065; PMCID: PMC4501632.
        View in: PubMed, PubMed Central
      28. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
        View in: PubMed, PubMed Central
      29. Shaked H, Guma M, Karin M. Analysis of NF-?B activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. PMID: 25736774.
        View in: PubMed
      30. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63. PMID: 25526314; PMCID: PMC4272447 [Available on 12/18/15].
        View in: PubMed, PubMed Central
      31. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. PMID: 25404284; PMCID: PMC4260592.
        View in: PubMed, PubMed Central
      32. Karin M. Whipping NF-?B to Submission via GADD45 and MKK7. Cancer Cell. 2014 Oct 13; 26(4):447-9. PMID: 25314072.
        View in: PubMed
      33. Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. PMID: 25267627; PMCID: PMC4205637.
        View in: PubMed, PubMed Central
      34. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-43. PMID: 25132496; PMCID: PMC4165611.
        View in: PubMed, PubMed Central
      35. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. PMID: 24910242; PMCID: PMC4079758.
        View in: PubMed, PubMed Central
      36. Taniguchi K, Karin M. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 2014 Feb; 26(1):54-74. PMID: 24552665.
        View in: PubMed
      37. Dhar D, Seki E, Karin M. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7. PMID: 24411937; PMCID: PMC3947913.
        View in: PubMed, PubMed Central
      38. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1090-5. PMID: 24395807; PMCID: PMC3903249.
        View in: PubMed, PubMed Central
      39. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. PMID: 24191041; PMCID: PMC3839688.
        View in: PubMed, PubMed Central
      40. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. PMID: 24120137; PMCID: PMC4015514.
        View in: PubMed, PubMed Central
      41. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIK-IKKa module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59. PMID: 23602409; PMCID: PMC3981467.
        View in: PubMed, PubMed Central
      42. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43. PMID: 23563314; PMCID: PMC3635720.
        View in: PubMed, PubMed Central
      43. Simonin Y, Vegna S, Akkari L, Grégoire D, Antoine E, Piette J, Floc'h N, Lassus P, Yu GY, Rosenberg AR, Karin M, Durantel D, Hibner U. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog. 2013 Mar; 9(3):e1003234. PMID: 23555249; PMCID: PMC3605200.
        View in: PubMed, PubMed Central
      44. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. PMID: 23341606; PMCID: PMC3568328.
        View in: PubMed, PubMed Central
      45. Wang K, Karin M. Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975. PMID: 24516778.
        View in: PubMed
      46. Wang K, Grivennikov SI, Karin M. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3. PMID: 23253923.
        View in: PubMed
      47. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. PMID: 23034650; PMCID: PMC3601659.
        View in: PubMed, PubMed Central
      48. Yu GY, He G, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang LH, Karin M. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21. PMID: 22959272; PMCID: PMC3483424.
        View in: PubMed, PubMed Central
      49. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. PMID: 22958918; PMCID: PMC3687365.
        View in: PubMed, PubMed Central
      50. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549; PMCID: PMC3397277.
        View in: PubMed, PubMed Central
      51. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. PMID: 22893683; PMCID: PMC3435160.
        View in: PubMed, PubMed Central
      52. Gaba A, Grivennikov SI, Do MV, Stumpo DJ, Blackshear PJ, Karin M. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93. PMID: 22865915; PMCID: PMC3424405.
        View in: PubMed, PubMed Central
      53. Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. PMID: 22705006; PMCID: PMC3523093.
        View in: PubMed, PubMed Central
      54. Font-Burgada J, Seki E, Karin M. CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2. PMID: 22698394; PMCID: PMC4718070.
        View in: PubMed, PubMed Central
      55. Aghajan M, Li N, Karin M. Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4. PMID: 22320909; PMCID: PMC3298015.
        View in: PubMed, PubMed Central
      56. DiDonato JA, Mercurio F, Karin M. NF-?B and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400. PMID: 22435567.
        View in: PubMed
      57. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. PMID: 22196886; PMCID: PMC3268914.
        View in: PubMed, PubMed Central
      58. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. An HNF4a-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47. PMID: 22153071; PMCID: PMC3251960.
        View in: PubMed, PubMed Central
      59. Kuraishy A, Karin M, Grivennikov SI. Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77. PMID: 22035839; PMCID: PMC3587290.
        View in: PubMed, PubMed Central
      60. Fujiwara R, Chen S, Karin M, Tukey RH. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-?B leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. PMID: 21983082; PMCID: PMC3428231.
        View in: PubMed, PubMed Central
      61. Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84. PMID: 21962514; PMCID: PMC3295636.
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      62. Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14. PMID: 21815634; PMCID: PMC3174326.
        View in: PubMed, PubMed Central
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      152. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. PMID: 15858576.
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      153. Karin M, Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life. 2005 Apr-May; 57(4-5):283-95. PMID: 16036612.
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      154. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11; 120(5):649-61. PMID: 15766528.
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      155. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8. PMID: 15692052.
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      156. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. PMID: 15685170.
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      157. Karin M. Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005; 2(4):386-90; discussion 394-5. PMID: 16267367; PMCID: PMC2713329.
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      158. Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004 Dec 20; 200(12):1647-55. PMID: 15611291; PMCID: PMC2211988.
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      159. Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8. PMID: 15601766; PMCID: PMC539759.
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      160. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. PMID: 15470505; PMCID: PMC524385.
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      161. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 08; 306(5694):271-5. PMID: 15358865.
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      162. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004 Sep; 6(3):297-305. PMID: 15380520.
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      163. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96. PMID: 15294155.
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      164. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004 Jun; 25(6):280-8. PMID: 15145317.
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      165. Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4. PMID: 15071597.
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      166. Greten FR, Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004 Apr 08; 206(2):193-9. PMID: 15013524.
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      167. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. PMID: 15037607.
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      168. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. PMID: 15029200.
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      169. Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 2004 Mar 01; 18(5):584-94. PMID: 15037551; PMCID: PMC374239.
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      170. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7. PMID: 14983030; PMCID: PMC356971.
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      171. Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 2004 Jan; 3(1):17-26. PMID: 14708018.
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      172. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37. PMID: 14614859.
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      173. Kato T, Delhase M, Hoffmann A, Karin M. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39. PMID: 14580335.
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      174. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 2003 May 01; 170(9):4630-7. PMID: 12707341.
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      175. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003 May; 9(5):575-81. PMID: 12692538.
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      176. Lin A, Karin M. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. PMID: 12654254.
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      177. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. PMID: 12689591.
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      178. Cao Y, Karin M. NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):215-23. PMID: 14635796.
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      179. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. PMID: 12637498.
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      180. Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol. 2003 Feb; 23(3):1061-74. PMID: 12529410; PMCID: PMC140693.
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      181. Maeda S, Karin M. Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 2003 Feb; 3(2):102-4. PMID: 12620404.
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      182. Shim J, Karin M. The control of mRNA stability in response to extracellular stimuli. Mol Cells. 2002 Dec 31; 14(3):323-31. PMID: 12521293.
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      183. Häcker H, Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2002 Dec; 2(6):431-3. PMID: 12498710.
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      184. Shim J, Lim H, R Yates J, Karin M. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell. 2002 Dec; 10(6):1331-44. PMID: 12504009.
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      185. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002 Oct; 17(4):525-35. PMID: 12387745.
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      186. Makris C, Roberts JL, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002 Sep; 22(18):6573-81. PMID: 12192055; PMCID: PMC135629.
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      187. Park JM, Greten FR, Li ZW, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002 Sep 20; 297(5589):2048-51. PMID: 12202685.
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      188. Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1631-5. PMID: 11980884.
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      189. Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002 Apr; 2(4):301-10. PMID: 12001991.
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      190. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002 Mar; 3(3):221-7. PMID: 11875461.
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      191. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23. PMID: 11920420.
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      192. Senftleben U, Karin M. The IKK/NF-kappa B pathway. Crit Care Med. 2002 Jan; 30(1 Suppl):S18-26. PMID: 11782557.
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      193. Senftleben U, Karin M. The IKK/NF-kappaB pathway. Crit Care Med. 2002 Jan; 30(1 Supp):S18-S26. PMID: 11891403.
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