Michael Karin

Title(s)Professor, Pharmacology
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    Tel Aviv University, Tel Aviv, IsraelB.Sc.Biology
    University of California, Los Angeles, Los Angeles, CAPh.D.Molecular Biology
    Fox Chase Institute for Cancer Research, Philadelphia, PAPostdoctoral ScholarMolecular Biology
    University of California, San Francisco, San Francisco, CAPostdoctoral ScholarBiochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Karin received his BSc in Biology from Tel Aviv University in 1975 and his Ph.D. in Molecular Biology from the University of California Los Angeles in 1979. He is currently a Distinguished Professor of Pharmacology and Pathology at the University of California San Diego School of Medicine, where he has been on the faculty since 1986. Dr. Karin has received numerous awards, including the Endocrine Society Oppenheimer Award for Excellence in 1990, American Cancer Society Research Professorship in 1999, C.E.R.I.E.S. Research Award for Physiology or Biology of the Skin in 2000, Harvey Prize in Human Health in 2011, Brupbacher Prize in Cancer Research in 2013, William B. Coley Award for Distinguished Research in Basic and Tumor Immunology in 2013, and an honorary Doctor of Medicine from the Technical University of Munich. He was a cofounder of Signal Pharmaceutical, which has become a part of Celgene, Inc. Dr. Karin had also served as a member of the National Advisory Council for Environmental Health Sciences. Dr. Karin was elected as a member of the US National Academy of Sciences in 2005, the National Academy of Medicine in 2011 and as an associate member of the European Molecular Biology Association in 2007. He became a fellow of the American Association for Cancer Research Academy in 2017. Dr. Karin’s current activity primarily focuses on understanding the relationship between inflammation, cancer, and metabolic disease as well as the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to discovering some of the most important stress- and inflammation-responsive signal transduction pathways and establishing molecular links between obesity, inflammation and cancer, Dr. Karin’s work has revealed new targets for cancer prevention and therapy as well as for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Diversity and Determinants of the Immune-Inflammatory Response to SARS-CoV-2
    NIH U54CA260591Sep 30, 2020 - Aug 31, 2022
    Role: Co-Principal Investigator
    Control of Lipogenesis and Hepatic Steatosis by Caspase-2
    NIH R01DK120714Mar 15, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Highly penetrant and immunogenic mouse models of non-viral HCC that are suitable for evaluation of immune checkpoint inhibitors
    NIH R01CA234128Dec 1, 2018 - Nov 30, 2023
    Role: Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Principal Investigator
    Role of p62/SQSTM1 in obesity-induced liver cancer
    NIH R01CA211794Feb 15, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Organelle Disorders in Pancreatitis
    NIH P01DK098108Sep 1, 2014 - Jun 30, 2021
    Role: Co-Investigator
    The Role of IL-17 in Alcoholic Liver Disease and Cancer
    NIH U01AA022614Sep 1, 2014 - Jun 30, 2020
    Role: Principal Investigator
    IKKalpha, autophagy, obesity and injury enhanced pancreatic cancer
    NIH R01CA163798Jul 16, 2012 - Apr 30, 2018
    Role: Principal Investigator
    TOR signaling and autophagy in obesity-promoted liver tumorigenesis
    NIH R01CA155120Jul 22, 2011 - May 31, 2016
    Role: Principal Investigator
    Pulmonary inflammation and lung cancer development and progression
    NIH R01CA132586May 5, 2008 - Apr 30, 2014
    Role: Principal Investigator
    IKK and the Control of Prostate Cancer Metastasis
    NIH R01CA127923Apr 13, 2007 - Feb 28, 2018
    Role: Principal Investigator
    Role of Inflammation in tumor promotion and progression
    NIH R01CA118165Dec 1, 2005 - Mar 31, 2017
    Role: Principal Investigator
    How Anthrax lethal factor kills macrophages
    NIH R01AI061712Jun 1, 2004 - May 31, 2010
    Role: Principal Investigator
    How Anthrax lethal factor kills activated macrophages
    NIH R21AI053528Sep 15, 2002 - Aug 31, 2005
    Role: Principal Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NF KAPPA B REGULATION AND FUNCTION
    NIH R13CA086394Mar 14, 2000 - Mar 13, 2001
    Role: Principal Investigator
    NF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of Inflammation
    NIH R37AI043477Jul 1, 1998 - May 31, 2023
    Role: Principal Investigator
    Regulation of NF-kappaB and IKK by proinflammatory stimuli
    NIH R01AI043477Jul 1, 1998 - May 31, 2018
    Role: Principal Investigator
    Functions and Mechanisms of Radiation Induced Responses
    NIH R01CA076188Feb 15, 1998 - Jul 31, 2007
    Role: Principal Investigator
    Stress Signaling Pathways in Toxicity and Disease
    NIH R01ES006376Jun 1, 1993 - Jul 31, 2013
    Role: Principal Investigator
    FASEB CONFERENCE--REGULATION OF GENE EXPRESSION
    NIH R13HL046015Jul 1, 1990 - Jun 30, 1991
    Role: Principal Investigator
    FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
    NIH P01CA050528Sep 8, 1989 - Jan 31, 1998
    Role: Principal Investigator
    IVEM and Image Analysis Resource
    NIH P41RR004050Dec 12, 1988 - Mar 31, 2014
    Role: Co-Investigator
    TISSUE SPECIFIC EXPRESSION OF GROWTH HORMONE GENE
    NIH R01DK038527Sep 1, 1987 - Apr 30, 1999
    Role: Principal Investigator
    GENETIC AND RECEPTOR MECHANISMS IN HYPERTENSION
    NIH P01HL035018Mar 1, 1986 - Dec 31, 2009
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R37ES004151Jan 1, 1986 - Mar 31, 2009
    Role: Principal Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES004151Jan 1, 1986 - Mar 31, 1998
    Role: Principal Investigator
    INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator
    INTERACTIONS OF HEAVY METAL IONS WITH THE HUMAN GENOME
    NIH R01ES003222Jul 1, 1983 - Dec 31, 1985
    Role: Principal Investigator
    Specialized Cancer Center Support Grant
    NIH P30CA023100Apr 1, 1978 - Apr 30, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Past and Future of Inflammation as a Target to Cancer Prevention. Cancer Prev Res (Phila). 2024 Apr 02; 17(4):141-155. Antonucci L, Karin M. PMID: 38271694.
      View in: PubMed   Mentions:    Fields:    
    2. A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 2024 Feb 29. Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. PMID: 38424270.
      View in: PubMed   Mentions: 1     Fields:    
    3. Cholesterol esterification and p53-mediated tumor suppression. Explor Target Antitumor Ther. 2023; 4(5):1122-1127. Li Y, Karin M, Prochownik EV. PMID: 38023993; PMCID: PMC10651352.
      View in: PubMed   Mentions:
    4. IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance. Sci Adv. 2023 10 27; 9(43):eadg5391. Rundberg Nilsson AJS, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 37889967; PMCID: PMC10610924.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC. Sci Adv. 2023 09 15; 9(37):eadh0831. Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. PMID: 37703359; PMCID: PMC10499313.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Multifaceted collagen-DDR1 signaling in cancer. Trends Cell Biol. 2023 Sep 12. Su H, Karin M. PMID: 37709651; PMCID: PMC10927612.
      View in: PubMed   Mentions:    Fields:    
    7. Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ Health Perspect. 2023 09; 131(9):97001. Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts PLSM, Tukey RH, Chen S. PMID: 37668303; PMCID: PMC10478510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    8. Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration. bioRxiv. 2023 Jul 21. Fini MA, Monks JA, Li M, Gerasimovskaya E, Paucek P, Wang K, Frid MG, Pugliese SC, Bratton D, Yu YR, Irwin D, Karin M, Wright RM, Stenmark KR. PMID: 37502951; PMCID: PMC10370167.
      View in: PubMed   Mentions:
    9. Collagen architecture and signaling orchestrate cancer development. Trends Cancer. 2023 09; 9(9):764-773. Su H, Karin M. PMID: 37400314.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Author Correction: A central role for JNK in obesity and insulin resistance. Nature. 2023 Jul; 619(7968):E25. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 37328696.
      View in: PubMed   Mentions:    Fields:    
    11. Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023 Jun; 618(7966):808-817. Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. PMID: 37344645; PMCID: PMC10284692.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651. Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. PMID: 37156770; PMCID: PMC10167314.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2300706120. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 37126700; PMCID: PMC10175751.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154. Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. PMID: 37100955; PMCID: PMC10130819.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    15. Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    16. P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2023 05 01; 77(5):1499-1511. Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C, Li Y, Prochownik EV, Karin M, Wang F, Li Y. PMID: 35398929.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential. Cell Genom. 2023 May 10; 3(5):100301. Carlessi R, Denisenko E, Boslem E, Köhn-Gaone J, Main N, Abu Bakar NDB, Shirolkar GD, Jones M, Beasley AB, Poppe D, Dwyer BJ, Jackaman C, Tjiam MC, Lister R, Karin M, Fallowfield JA, Kendall TJ, Forbes SJ, Gray ES, Olynyk JK, Yeoh G, Forrest ARR, Ramm GA, Febbraio MA, Tirnitz-Parker JEE. PMID: 37228755; PMCID: PMC10203275.
      View in: PubMed   Mentions: 2  
    18. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. J Hepatol. 2023 08; 79(2):362-377. He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M. PMID: 36996941.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    19. Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells. bioRxiv. 2023 Mar 06. Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang J, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. PMID: 36945365; PMCID: PMC10028807.
      View in: PubMed   Mentions:
    20. IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance. bioRxiv. 2023 Mar 02. Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M. PMID: 36747722; PMCID: PMC9900858.
      View in: PubMed   Mentions:
    21. Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
      View in: PubMed   Mentions:    Fields:    
    22. Oxidized mitochondrial DNA: a protective signal gone awry. Trends Immunol. 2023 03; 44(3):188-200. Xian H, Karin M. PMID: 36739208.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics. Cell Death Dis. 2022 11 15; 13(11):959. Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, Tixador P, Sproul AA, Brugg B, Reboud-Ravaux M, Troy CM, Shelanski ML, Bouaziz S, Karin M, El Amri C, Jacotot ED. PMID: 36379916; PMCID: PMC9666555.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature. 2022 10; 610(7931):356-365. Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF. PMID: 36198802; PMCID: PMC9949942.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    25. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    26. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    27. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Semin Liver Dis. 2022 08; 42(3):233-249. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. PMID: 36001995; PMCID: PMC9662188.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    28. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab. 2022 08 02; 34(8):1201-1213.e5. Gao H, Jin Z, Bandyopadhyay G, Wang G, Zhang D, Rocha KCE, Liu X, Zhao H, Kisseleva T, Brenner DA, Karin M, Ying W. PMID: 35921818; PMCID: PMC9365100.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    29. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun. 2022 07 27; 13(1):4346. Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. PMID: 35896521; PMCID: PMC9329322.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    30. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022 08 09; 55(8):1370-1385.e8. Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. PMID: 35835107; PMCID: PMC9378606.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    31. Diabesity? No worries, FKBP11 to the rescue. Cell Metab. 2022 07 05; 34(7):942-944. Karin M. PMID: 35793657.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    32. NF-κB: A Double-Edged Sword Controlling Inflammation. Biomedicines. 2022 May 27; 10(6). Liu D, Zhong Z, Karin M. PMID: 35740272; PMCID: PMC9219609.
      View in: PubMed   Mentions: 20  
    33. Concerted BAG3 and SIRPα blockade impairs pancreatic tumor growth. Cell Death Discov. 2022 Mar 03; 8(1):94. De Marco M, Gauttier V, Pengam S, Mary C, Ranieri B, Basile A, Festa M, Falco A, Reppucci F, Cammarota AL, Acernese F, De Laurenzi V, Sala G, Brongo S, Miyasaka M, Shalapour S, Vanhove B, Poirier N, Iaccarino R, Karin M, Turco MC, Rosati A, Marzullo L. PMID: 35241649; PMCID: PMC8894496.
      View in: PubMed   Mentions: 2  
    34. Concurrent Disruption of the Ras/MAPK and NF-κB Pathways Induces Circadian Deregulation and Hepatocarcinogenesis. Mol Cancer Res. 2022 Mar 01; 20(3):337-349. Hanley KL, Liang Y, Wang G, Lin X, Yang M, Karin M, Fu W, Feng GS. PMID: 34810213; PMCID: PMC8898265.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    35. IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines. Proc Natl Acad Sci U S A. 2022 02 08; 119(6). Song NY, Li X, Ma B, Willette-Brown J, Zhu F, Jiang C, Su L, Shetty J, Zhao Y, Shi G, Banerjee S, Wu X, Tran B, Nussinov R, Karin M, Hu Y. PMID: 35121655; PMCID: PMC8833198.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    36. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nat Commun. 2021 12 09; 12(1):7172. Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. PMID: 34887405; PMCID: PMC8660815.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    37. "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. Cell Metab. 2021 12 07; 33(12):2316-2328. Febbraio MA, Karin M. PMID: 34619076; PMCID: PMC8665123.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    38. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. Regulation of antitumor immunity by inflammation-induced epigenetic alterations. Cell Mol Immunol. 2022 01; 19(1):59-66. Karin M, Shalapour S. PMID: 34465885; PMCID: PMC8752743.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    40. The neglected brothers come of age: B cells and cancer. Semin Immunol. 2021 02; 52:101479. Shalapour S, Karin M. PMID: 34215491; PMCID: PMC8545794.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 09; 191(9):1564-1579. Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. PMID: 34119473; PMCID: PMC8406794.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    42. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11. Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    43. Macropinocytosis: the big drinker behind cancer cell self-consumption. Autophagy. 2021 05; 17(5):1290-1291. Su H, Yang F, Sun B, Karin M. PMID: 33879021; PMCID: PMC8143249.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. PMID: 33833060; PMCID: PMC8054017.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    45. Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis. Cancers (Basel). 2021 Mar 25; 13(7). Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Karin M, Itoh Y. PMID: 33806040; PMCID: PMC8037653.
      View in: PubMed   Mentions: 4  
    46. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 05 10; 39(5):678-693.e11. Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. PMID: 33740421; PMCID: PMC8119368.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    47. From Liver Fat to Cancer: Perils of the Western Diet. Cancers (Basel). 2021 Mar 04; 13(5). Kim JY, He F, Karin M. PMID: 33806428; PMCID: PMC7961422.
      View in: PubMed   Mentions: 9  
    48. Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, Cheng Z, Haybaeck J, Kenner L, Fisch KM, Bourgon R, Hernandez G, Lill JR, Liu S, Carter H, Mellman I, Karin M, Shalapour S. PMID: 33602823; PMCID: PMC7923353.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    49. Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study. BMJ Open. 2021 02 12; 11(2):e043584. Ebinger JE, Botwin GJ, Albert CM, Alotaibi M, Arditi M, Berg AH, Binek A, Botting P, Fert-Bober J, Figueiredo JC, Grein JD, Hasan W, Henglin M, Hussain SK, Jain M, Joung S, Karin M, Kim EH, Li D, Liu Y, Luong E, McGovern DPB, Merchant A, Merin N, Miles PB, Minissian M, Nguyen TT, Raedschelders K, Rashid MA, Riera CE, Riggs RV, Sharma S, Sternbach S, Sun N, Tourtellotte WG, Van Eyk JE, Sobhani K, Braun JG, Cheng S. PMID: 33579769; PMCID: PMC7883610.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    50. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway. J Hepatol. 2021 06; 74(6):1429-1441. Conde de la Rosa L, Garcia-Ruiz C, Vallejo C, Baulies A, Nuñez S, Monte MJ, Marin JJG, Baila-Rueda L, Cenarro A, Civeira F, Fuster J, Garcia-Valdecasas JC, Ferrer J, Karin M, Ribas V, Fernandez-Checa JC. PMID: 33515644; PMCID: PMC8573791.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    51. Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 2021 05; 18(5):261-279. Hou J, Karin M, Sun B. PMID: 33469195; PMCID: PMC8978805.
      View in: PubMed   Mentions: 92     Fields:    Translation:Humans
    52. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31259-31266. Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. PMID: 33229553; PMCID: PMC7733785.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    53. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    54. PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. 2020 08 10; 38(2):247-262.e11. Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, Metallo CM, Karin M, Diaz-Meco MT, Moscat J. PMID: 32589943; PMCID: PMC7423690.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    55. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. 2020 06 17; 41(4):405-416. He F, Antonucci L, Karin M. PMID: 32347301; PMCID: PMC7298623.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    56. Neoadjuvant rituximab modulates the tumor immune environment in patients with high risk prostate cancer. J Transl Med. 2020 05 28; 18(1):214. Ryan ST, Zhang J, Burner DN, Liss M, Pittman E, Muldong M, Shabaik A, Woo J, Basler N, Cunha J, Shalapour S, Estrada MV, Karin M, Messer K, Howell S, Kane CJ, Jamieson CAM. PMID: 32466781; PMCID: PMC7257145.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    57. Immunotherapy, Inflammation and Colorectal Cancer. Cells. 2020 03 04; 9(3). Lichtenstern CR, Ngu RK, Shalapour S, Karin M. PMID: 32143413; PMCID: PMC7140520.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimals
    58. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020 03; 8(1). Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMS, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJ, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM. PMID: 32209603; PMCID: PMC7064135.
      View in: PubMed   Mentions: 377     Fields:    Translation:Humans
    59. NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. J Hepatol. 2020 06; 72(6):1182-1195. He F, Antonucci L, Yamachika S, Zhang Z, Taniguchi K, Umemura A, Hatzivassiliou G, Roose-Girma M, Reina-Campos M, Duran A, Diaz-Meco MT, Moscat J, Sun B, Karin M. PMID: 32105670; PMCID: PMC8054878.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    60. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    61. Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annu Rev Immunol. 2020 04 26; 38:649-671. Shalapour S, Karin M. PMID: 32040356; PMCID: PMC8936002.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    62. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622; PMCID: PMC8012106.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    63. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ. 2020 07; 27(7):2206-2216. Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. PMID: 31992855; PMCID: PMC7308363.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    64. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. J Hepatol. 2020 05; 72(5):960-975. Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. PMID: 31954207.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    65. Loss or Inhibition of Stromal-Derived PlGF Prolongs Survival of Mice with Imatinib-Resistant Bcr-Abl1+ Leukemia. Cancer Cell. 2020 Jan 13; 37(1):135-136. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 31935370.
      View in: PubMed   Mentions:    Fields:    
    66. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020 01 13; 11(1):189. Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardí M, Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M, Hee Lee J, Muñoz-Cánoves P. PMID: 31929511; PMCID: PMC6955241.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    67. Sestrins are evolutionarily conserved mediators of exercise benefits. Nat Commun. 2020 01 13; 11(1):190. Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH. PMID: 31929512; PMCID: PMC6955242.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    68. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    69. Correction: Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 Nov 15; 79(22):5897. Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson L, Karasic T, Llovet J, Finn R, Groopman J, El-Serag H, Monga S, Wang XW, Karin M, Schwartz R, Tanabe K, Roberts L, Gunaratne P, Tsung A, Brown K, Lawrence T, Salem R, Singal A, Kim A, Rabiee A, Resar L, Meyer J, Hoshida Y, He AR, Ghoshal K, Ryan P, Jaffee E, Guha C, Mishra L, Coleman N, Ahmed M. PMID: 31772073.
      View in: PubMed   Mentions: 3     Fields:    
    70. Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-κB kinase subunit β-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769. Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063; PMCID: PMC6962627.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    71. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312. Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566; PMCID: PMC6957844.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    72. Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 09 01; 79(17):4326-4330. Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L, Coleman CN, Ahmed MM. PMID: 31481419; PMCID: PMC8330805.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    73. The immunobiology of hepatocellular carcinoma in humans and mice: Basic concepts and therapeutic implications. J Hepatol. 2020 01; 72(1):167-182. Hou J, Zhang H, Sun B, Karin M. PMID: 31449859.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimals
    74. Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation. Immunity. 2019 07 16; 51(1):15-26. Shalapour S, Karin M. PMID: 31315033; PMCID: PMC6640850.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    75. The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 2019 05 13; 35(5):714-720. Todoric J, Karin M. PMID: 31085174.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    76. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    77. Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach. Mol Cancer Res. 2019 07; 17(7):1493-1502. Friemel J, Frick L, Unger K, Egger M, Parrotta R, Böge YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. PMID: 30967480.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    78. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 2019 04; 48(4):459-470. Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. PMID: 30973461; PMCID: PMC6461375.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    79. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):785. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29785003; PMCID: PMC7133393.
      View in: PubMed   Mentions: 11     Fields:    
    80. Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab. 2019 01 08; 29(1):18-26. Febbraio MA, Reibe S, Shalapour S, Ooi GJ, Watt MJ, Karin M. PMID: 30449681; PMCID: PMC6326872.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimals
    81. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 03; 156(4):1156-1172.e6. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. PMID: 30445007; PMCID: PMC6409207.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    82. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485; PMCID: PMC6196518.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    83. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454; PMCID: PMC6159928.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    84. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212; PMCID: PMC6166836.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    85. Author Correction: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2018 09; 561(7721):E1. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29973714; PMCID: PMC7871211.
      View in: PubMed   Mentions: 1     Fields:    
    86. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
      View in: PubMed   Mentions: 440     Fields:    Translation:AnimalsCells
    87. The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol. 2018 07; 15(7):397-411. Tripathi A, Debelius J, Brenner DA, Karin M, Loomba R, Schnabl B, Knight R. PMID: 29748586; PMCID: PMC6319369.
      View in: PubMed   Mentions: 493     Fields:    Translation:Humans
    88. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6. Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692; PMCID: PMC6005359.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    89. Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET. J Hepatol. 2018 07; 69(1):79-88. Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. PMID: 29505847; PMCID: PMC6008184.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    90. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479; PMCID: PMC5864239.
      View in: PubMed   Mentions: 2382     Fields:    Translation:HumansAnimalsCells
    91. NF-κB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 05; 18(5):309-324. Taniguchi K, Karin M. PMID: 29379212.
      View in: PubMed   Mentions: 1013     Fields:    Translation:HumansAnimalsCells
    92. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E812-E821. Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. PMID: 29311298; PMCID: PMC5789942.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    93. Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 12 21; 552(7685):430. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29168501; PMCID: PMC8594569.
      View in: PubMed   Mentions: 3     Fields:    
    94. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017 Dec 11; 32(6):824-839.e8. Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, Reya T, Diaz-Meco M, Moscat J, Karin M. PMID: 29153842; PMCID: PMC5730340.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    95. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 2017 11 16; 551(7680):340-345. Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, Downes M, Yu RT, Evans RM, Dorrestein PC, Knight R, Benner C, Anstee QM, Karin M. PMID: 29144460; PMCID: PMC5884449.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    96. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077; PMCID: PMC5552280.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    97. IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. 2017 10; 60(10):2021-2032. Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. PMID: 28725915.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    98. Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nat Immunol. 2017 Jul 19; 18(8):861-869. Afonina IS, Zhong Z, Karin M, Beyaert R. PMID: 28722711.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansCells
    99. DNA methylation markers for diagnosis and prognosis of common cancers. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):7414-7419. Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K. PMID: 28652331; PMCID: PMC5514741.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansCells
    100. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017 05; 24(5):929-943. Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. PMID: 28387757; PMCID: PMC5423119.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    101. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1432-E1440. Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Paszek M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. PMID: 28167773; PMCID: PMC5338369.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    102. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1643-1648. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. PMID: 28130546; PMCID: PMC5320959.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    103. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nat Immunol. 2017 03; 18(3):354-363. Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. PMID: 28114291; PMCID: PMC5321575.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    104. Corrigendum: PI3Kγ is a molecular switch that controls immune suppression. Nature. 2017 02 02; 542(7639):124. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27974794.
      View in: PubMed   Mentions: 17     Fields:    
    105. Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prev Res (Phila). 2016 Dec; 9(12):895-905. Todoric J, Antonucci L, Karin M. PMID: 27913448; PMCID: PMC5142754.
      View in: PubMed   Mentions: 144     Fields:    Translation:Humans
    106. Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell. 2016 11 03; 167(4):1052-1066.e18. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. PMID: 27814504; PMCID: PMC5908236.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    107. p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 2016 Oct 20; 167(3):606-609. Moscat J, Karin M, Diaz-Meco MT. PMID: 27768885; PMCID: PMC5114003.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansCells
    108. p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 2016 10 10; 30(4):595-609. Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. PMID: 27728806; PMCID: PMC5081228.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    109. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016 11 17; 539(7629):437-442. Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. PMID: 27642729; PMCID: PMC5479689.
      View in: PubMed   Mentions: 530     Fields:    Translation:HumansAnimalsCells
    110. IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1. Hepatology. 2016 10; 64(4):1217-31. Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. PMID: 27396433.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    111. p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. FEBS Lett. 2016 08; 590(15):2375-97. Taniguchi K, Yamachika S, He F, Karin M. PMID: 27404485; PMCID: PMC4983218.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    112. Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases. Clin Exp Rheumatol. 2016 Jul-Aug; 34(4 Suppl 98):12-6. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27586797.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    113. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14; 166(2):288-298. Zhong Z, Sanchez-Lopez E, Karin M. PMID: 27419869; PMCID: PMC4947210.
      View in: PubMed   Mentions: 287     Fields:    Translation:HumansAnimals
    114. Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. Cell Rep. 2016 06 28; 16(1):120-132. McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS. PMID: 27320908; PMCID: PMC4927403.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    115. Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Sci Signal. 2016 06 07; 9(431):re5. Lee JH, Cho US, Karin M. PMID: 27273098; PMCID: PMC4902175.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    116. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948. Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 27211490; PMCID: PMC4907799.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimalsCells
    117. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016 05 17; 7:11551. de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. PMID: 27187615; PMCID: PMC4873670.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    118. Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis. Cell Metab. 2016 05 10; 23(5):759-61. Shalapour S, Karin M. PMID: 27166937.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    119. Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2. Carcinogenesis. 2016 06; 37(6):541-6. Karin M, Dhar D. PMID: 27207669; PMCID: PMC4876993.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    120. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428; PMCID: PMC4769378.
      View in: PubMed   Mentions: 497     Fields:    Translation:AnimalsCells
    121. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399; PMCID: PMC4878828.
      View in: PubMed   Mentions: 15  
    122. Reparative inflammation takes charge of tissue regeneration. Nature. 2016 Jan 21; 529(7586):307-15. Karin M, Clevers H. PMID: 26791721; PMCID: PMC5228603.
      View in: PubMed   Mentions: 332     Fields:    Translation:HumansAnimalsCells
    123. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. PMID: 26792803; PMCID: PMC4761524.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    124. Obesity and Cancer: The Oil that Feeds the Flame. Cell Metab. 2016 Jan 12; 23(1):48-62. Font-Burgada J, Sun B, Karin M. PMID: 26771116.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimals
    125. Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14670-5. Yin AH, Peng CF, Zhao X, Caughey BA, Yang JX, Liu J, Huang WW, Liu C, Luo DH, Liu HL, Chen YY, Wu J, Hou R, Zhang M, Ai M, Zheng L, Xue RQ, Mai MQ, Guo FF, Qi YM, Wang DM, Krawczyk M, Zhang D, Wang YN, Huang QF, Karin M, Zhang K. PMID: 26554006; PMCID: PMC4664371.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    126. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nat Commun. 2015 Nov 02; 6:8695. Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC. PMID: 26522614; PMCID: PMC4659838.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    127. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):E6166-74. Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. PMID: 26512112; PMCID: PMC4653219.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    128. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44. Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. PMID: 26502405; PMCID: PMC4653079.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    129. The IL-23 to IL-17 cascade inflammation-related cancers. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S87-90. Wang K, Karin M. PMID: 26457610.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    130. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nat Commun. 2015 Oct 12; 6:8428. Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. PMID: 26455434.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    131. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Sep 21; 5:14029. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. PMID: 26390293; PMCID: PMC4642703.
      View in: PubMed   Mentions: 3     Fields:    
    132. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. 2016 05 19; 35(20):2634-44. Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. PMID: 26364612; PMCID: PMC4791217.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    133. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest. 2015 Sep; 125(9):3347-55. Shalapour S, Karin M. PMID: 26325032; PMCID: PMC4588298.
      View in: PubMed   Mentions: 351     Fields:    Translation:HumansAnimalsCells
    134. Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer. Cell. 2015 Aug 13; 162(4):766-79. Font-Burgada J, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. PMID: 26276631; PMCID: PMC4545590.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    135. Immune Infiltration and Prostate Cancer. Front Oncol. 2015; 5:128. Strasner A, Karin M. PMID: 26217583; PMCID: PMC4495337.
      View in: PubMed   Mentions: 99  
    136. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunol Rev. 2015 Jul; 266(1):161-74. Wu X, Karin M. PMID: 26085214.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    137. Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev. 2015 Aug; 26(4):389-403. Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. PMID: 26119834; PMCID: PMC4526340.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    138. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. PMID: 26109050; PMCID: PMC4495398.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimalsCells
    139. Tumor-Elicited Inflammation and Colorectal Cancer. Adv Cancer Res. 2015; 128:173-96. Wang K, Karin M. PMID: 26216633.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    140. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015 May 07; 521(7550):94-8. Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. PMID: 25924065; PMCID: PMC4501632.
      View in: PubMed   Mentions: 270     Fields:    Translation:HumansAnimalsCells
    141. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death Differ. 2015 Dec; 22(12):1985-94. Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. PMID: 25909884; PMCID: PMC4816107.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    142. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. PMID: 25819761; PMCID: PMC4377584.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    143. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan KL, Karin M. PMID: 25731159; PMCID: PMC4447318.
      View in: PubMed   Mentions: 322     Fields:    Translation:HumansAnimalsCells
    144. Analysis of NF-κB activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. Shaked H, Guma M, Karin M. PMID: 25736774.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    145. IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5. Cell Death Differ. 2015 May; 22(5):852-61. Kobayashi K, Toguchida J, Karin M, Kato T. PMID: 25526093; PMCID: PMC4392083.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    146. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18; 41(6):1052-63. Wang K, Kim MK, Di Caro G, Wong J, Shalapour S, Wan J, Zhang W, Zhong Z, Sanchez-Lopez E, Wu LW, Taniguchi K, Feng Y, Fearon E, Grivennikov SI, Karin M. PMID: 25526314; PMCID: PMC4272447.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    147. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. PMID: 25457612; PMCID: PMC4303546.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    148. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17200-5. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. PMID: 25404284; PMCID: PMC4260592.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    149. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015 Feb; 29(2):408-17. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. PMID: 25366347; PMCID: PMC4314228.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    150. Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response. Cancer Res. 2014 Dec 15; 74(24):7274-84. Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A. PMID: 25336190; PMCID: PMC4349570.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    151. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014 Oct 13; 26(4):549-64. Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M. PMID: 25314080.
      View in: PubMed   Mentions: 306     Fields:    Translation:HumansAnimalsCells
    152. Whipping NF-κB to Submission via GADD45 and MKK7. Cancer Cell. 2014 Oct 13; 26(4):447-9. Karin M. PMID: 25314072.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    153. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633; PMCID: PMC4382461.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    154. IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30; 5:4977. Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. PMID: 25266676; PMCID: PMC4298287.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    155. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14776-81. Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. PMID: 25267627; PMCID: PMC4205637.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    156. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014 Nov 03; 33(21):2581-96. Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. PMID: 25260751; PMCID: PMC4282369.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    157. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 26594598; PMCID: PMC4648354.
      View in: PubMed   Mentions: 5  
    158. Roles of tumor suppressors in regulating tumor-associated inflammation. Cell Death Differ. 2014 Nov; 21(11):1677-86. Yang L, Karin M. PMID: 25190145; PMCID: PMC4211367.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    159. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13870-5. Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M. PMID: 25189770; PMCID: PMC4183333.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    160. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343. Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496; PMCID: PMC4165611.
      View in: PubMed   Mentions: 269     Fields:    Translation:AnimalsCells
    161. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nat Commun. 2014 Jul 29; 5:4513. Fang DF, He K, Wang N, Sang ZH, Qiu X, Xu G, Jian Z, Liang B, Li T, Li HY, Li AL, Zhou T, Gong WL, Yang B, Karin M, Zhang XM, Li WH. PMID: 25072696.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    162. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    163. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44. Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. PMID: 24910242; PMCID: PMC4079758.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    164. The therapeutic value of targeting inflammation in gastrointestinal cancers. Trends Pharmacol Sci. 2014 Jul; 35(7):349-57. Sun B, Karin M. PMID: 24881011; PMCID: PMC4108072.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    165. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14; 25(4):469-83. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM. PMID: 24735923; PMCID: PMC3995091.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    166. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 2014 Feb; 26(1):54-74. Taniguchi K, Karin M. PMID: 24552665.
      View in: PubMed   Mentions: 310     Fields:    Translation:HumansAnimalsCells
    167. Chemotherapy, immunity and microbiota--a new triumvirate? Nat Med. 2014 Feb; 20(2):126-7. Karin M, Jobin C, Balkwill F. PMID: 24504404; PMCID: PMC4339017.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    168. Tumor infiltrating B-cells are increased in prostate cancer tissue. J Transl Med. 2014 Jan 30; 12:30. Woo JR, Liss MA, Muldong MT, Palazzi K, Strasner A, Ammirante M, Varki N, Shabaik A, Howell S, Kane CJ, Karin M, Jamieson CA. PMID: 24475900; PMCID: PMC3914187.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    169. Critical role for IL-1β in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):E702-11. Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. PMID: 24469832; PMCID: PMC3926043.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    170. Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. PLoS One. 2014; 9(1):e83391. Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. PMID: 24416163; PMCID: PMC3885413.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    171. NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7. Dhar D, Seki E, Karin M. PMID: 24411937; PMCID: PMC3947913.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    172. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1090-5. Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. PMID: 24395807; PMCID: PMC3903249.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    173. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91. Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. PMID: 24333183; PMCID: PMC3960359.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    174. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19143-8. Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. PMID: 24191041; PMCID: PMC3839688.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    175. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96. He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. PMID: 24120137; PMCID: PMC4015514.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    176. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal. 2013 Oct 01; 6(295):ra87. Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ. PMID: 24084649; PMCID: PMC4004444.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    177. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metab. 2013 Dec 03; 18(6):792-801. Lee JH, Budanov AV, Karin M. PMID: 24055102; PMCID: PMC3858445.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    178. IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunol. 2014 Mar; 7(2):257-67. Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, Davis IC, Lin M, Tomé D, Karin M, Sun Y, Boyaka PN. PMID: 23839064; PMCID: PMC4053573.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    179. An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes Dev. 2013 Jul 01; 27(13):1435-40. Ammirante M, Kuraishy AI, Shalapour S, Strasner A, Ramirez-Sanchez C, Zhang W, Shabaik A, Karin M. PMID: 23796898; PMCID: PMC3713424.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    180. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1199-209.e4. Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. PMID: 23622129; PMCID: PMC3786712.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    181. Inflammation and liver tumorigenesis. Front Med. 2013 Jun; 7(2):242-54. Sun B, Karin M. PMID: 23681888.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    182. A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 2013 May 13; 23(5):647-59. Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. PMID: 23602409; PMCID: PMC3981467.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    183. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. J Clin Invest. 2013 May; 123(5):2231-43. Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, Karin M. PMID: 23563314; PMCID: PMC3635720.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    184. Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis. PLoS Pathog. 2013 Mar; 9(3):e1003234. Simonin Y, Vegna S, Akkari L, Grégoire D, Antoine E, Piette J, Floc'h N, Lassus P, Yu GY, Rosenberg AR, Karin M, Durantel D, Hibner U. PMID: 23555249; PMCID: PMC3605200.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    185. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J. 2013 Mar 20; 32(6):816-28. Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. PMID: 23422957; PMCID: PMC3604721.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    186. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. PMID: 23341606; PMCID: PMC3568328.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    187. Common flora and intestine: A carcinogenic marriage. Cell Logist. 2013 Jan 01; 3(1):e24975. Wang K, Karin M. PMID: 24516778; PMCID: PMC3906427.
      View in: PubMed   Mentions: 3  
    188. p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24. Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. PMID: 23271722; PMCID: PMC3605785.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    189. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013 Apr; 72 Suppl 2:ii100-3. Wang K, Grivennikov SI, Karin M. PMID: 23253923.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    190. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. J Biol Chem. 2013 Jan 04; 288(1):598-607. Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW. PMID: 23155052; PMCID: PMC3537058.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    191. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. PMID: 23034650; PMCID: PMC3601659.
      View in: PubMed   Mentions: 659     Fields:    Translation:HumansAnimalsCells
    192. Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell. 2012 Oct 26; 48(2):313-21. Yu GY, He G, Li CY, Tang M, Grivennikov S, Tsai WT, Wu MS, Hsu CW, Tsai Y, Wang LH, Karin M. PMID: 22959272; PMCID: PMC3483424.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    193. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metab. 2012 Sep 05; 16(3):311-21. Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. PMID: 22958918; PMCID: PMC3687365.
      View in: PubMed   Mentions: 141     Fields:    Translation:Animals
    194. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. PMID: 22488549; PMCID: PMC3397277.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    195. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. PMID: 22893683; PMCID: PMC3435160.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    196. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012 Sep 01; 189(5):2089-93. Gaba A, Grivennikov SI, Do MV, Stumpo DJ, Blackshear PJ, Karin M. PMID: 22865915; PMCID: PMC3424405.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    197. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. PLoS Pathog. 2012; 8(7):e1002812. Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. PMID: 22829768; PMCID: PMC3400567.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    198. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20. Seki E, Brenner DA, Karin M. PMID: 22705006; PMCID: PMC3523093.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimalsCells
    199. CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2. Font-Burgada J, Seki E, Karin M. PMID: 22698394; PMCID: PMC4718070.
      View in: PubMed   Mentions: 4     Fields:    
    200. IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77. Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. PMID: 22544702; PMCID: PMC3369682.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    201. IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade. Biochem J. 2012 Mar 15; 442(3):723-32. Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. PMID: 22364283.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    202. Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:10-4. Aghajan M, Li N, Karin M. PMID: 22320909; PMCID: PMC3298015.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    203. NF-κB and the link between inflammation and cancer. Immunol Rev. 2012 Mar; 246(1):379-400. DiDonato JA, Mercurio F, Karin M. PMID: 22435567.
      View in: PubMed   Mentions: 694     Fields:    Translation:HumansAnimalsCells
    204. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):E177-86. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. PMID: 22203995; PMCID: PMC3268290.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    205. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. PMID: 22196886; PMCID: PMC3268914.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    206. An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell. 2011 Dec 09; 147(6):1233-47. Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. PMID: 22153071; PMCID: PMC3251960.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    207. Obesity, inflammation, and liver cancer. J Hepatol. 2012 Mar; 56(3):704-13. Sun B, Karin M. PMID: 22120206; PMCID: PMC3889660.
      View in: PubMed   Mentions: 229     Fields:    Translation:Humans
    208. Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 2011 Nov; 1(6):496-507. Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. PMID: 22389871; PMCID: PMC3290412.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    209. Tumor promotion via injury- and death-induced inflammation. Immunity. 2011 Oct 28; 35(4):467-77. Kuraishy A, Karin M, Grivennikov SI. PMID: 22035839; PMCID: PMC3587290.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimals
    210. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 2012 Jan; 142(1):109-118.e2. Fujiwara R, Chen S, Karin M, Tukey RH. PMID: 21983082; PMCID: PMC3428231.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    211. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 2011 Sep 30; 147(1):173-84. Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. PMID: 21962514; PMCID: PMC3295636.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    212. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain. 2011 Sep; 134(Pt 9):2722-35. Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. PMID: 21908876.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    213. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. J Med Chem. 2011 Sep 22; 54(18):6206-14. Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. PMID: 21815634; PMCID: PMC3174326.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    214. Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. PMID: 21825016; PMCID: PMC3171091.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    215. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13710-5. Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A. PMID: 21807998; PMCID: PMC3158164.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    216. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol. 2011 Jul 19; 12(8):715-23. Ben-Neriah Y, Karin M. PMID: 21772280.
      View in: PubMed   Mentions: 666     Fields:    Translation:HumansAnimals
    217. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 2011 Jul 22; 35(1):34-44. Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. PMID: 21683629; PMCID: PMC3889666.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    218. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 2011 Jun 14; 19(6):740-53. Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, Dias S, Verfaillie C, Clark RE, Brümmendorf TH, Vandenberghe P, Rafii S, Holyoake T, Hochhaus A, Cools J, Karin M, Carmeliet G, Dewerchin M, Carmeliet P. PMID: 21665148.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    219. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nat Rev Immunol. 2011 Jun 10; 11(7):457-68. Häcker H, Tseng PH, Karin M. PMID: 21660053.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    220. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. PMID: 21305529; PMCID: PMC3106119.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    221. IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 2011 May; 41(5):1266-77. Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. PMID: 21469085.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    222. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 2011 Apr 12; 19(4):429-31. Li N, Grivennikov SI, Karin M. PMID: 21481782; PMCID: PMC3111086.
      View in: PubMed   Mentions: 136     Fields:    
    223. Crystal structure of inhibitor of κB kinase β. Nature. 2011 Apr 21; 472(7343):325-30. Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. PMID: 21423167; PMCID: PMC3081413.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    224. Transcriptional regulation of the Th17 immune response by IKK(alpha). J Exp Med. 2011 Apr 11; 208(4):787-96. Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. PMID: 21402739; PMCID: PMC3135338.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    225. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011 Mar; 70 Suppl 1:i104-8. Grivennikov SI, Karin M. PMID: 21339211.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimals
    226. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 2011 Feb 24; 470(7335):548-53. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. PMID: 21326202; PMCID: PMC3166217.
      View in: PubMed   Mentions: 326     Fields:    Translation:HumansAnimalsCells
    227. Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci. 2011 Jan; 1217:191-206. Kim S, Karin M. PMID: 21276007; PMCID: PMC4383094.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    228. IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun. 2011; 2:318. Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. PMID: 21587235; PMCID: PMC3113230.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    229. NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 2011 Jan; 21(1):159-68. He G, Karin M. PMID: 21187858; PMCID: PMC3193410.
      View in: PubMed   Mentions: 552     Fields:    Translation:AnimalsCells
    230. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249; PMCID: PMC3017162.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    231. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ. Nat Immunol. 2011 Feb; 12(2):144-50. Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. PMID: 21170027; PMCID: PMC3677078.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    232. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. PMID: 21135226; PMCID: PMC3009768.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    233. Magnetically vectored nanocapsules for tumor penetration and remotely switchable on-demand drug release. Nano Lett. 2010 Dec 08; 10(12):5088-92. Kong SD, Zhang W, Lee JH, Brammer K, Lal R, Karin M, Jin S. PMID: 21038917.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    234. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18956-60. Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. PMID: 20956327; PMCID: PMC2973856.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    235. Stressin' Sestrins take an aging fight. EMBO Mol Med. 2010 Oct; 2(10):388-400. Budanov AV, Lee JH, Karin M. PMID: 20878915; PMCID: PMC3166214.
      View in: PubMed   Mentions: 116     Fields:    Translation:Humans
    236. Peering into the aftermath: JAKi rips STAT3 in cancer. Nat Med. 2010 Oct; 16(10):1085-7. Greten FR, Karin M. PMID: 20930749.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    237. Sphingolipids: the oil on the TRAFire that promotes inflammation. Sci Signal. 2010 Sep 28; 3(141):pe34. Napolitano G, Karin M. PMID: 20876871.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    238. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010 Oct 01; 70(19):7465-75. Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. PMID: 20841473; PMCID: PMC2948598.
      View in: PubMed   Mentions: 340     Fields:    Translation:AnimalsCells
    239. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 2010 Sep 24; 33(3):400-11. Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, Lebon P, Rozenberg F, Karin M, Tardieu M, Al-Muhsen S, Jouanguy E, Zhang SY, Abel L, Casanova JL. PMID: 20832341; PMCID: PMC2946444.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansCells
    240. Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Mol Cell. 2010 Aug 27; 39(4):570-82. Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. PMID: 20797629.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    241. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. J Clin Invest. 2010 Jul; 120(7):2563-74. Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. PMID: 20530876; PMCID: PMC2898608.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    242. Inflammation and colon cancer. Gastroenterology. 2010 Jun; 138(6):2101-2114.e5. Terzic J, Grivennikov S, Karin E, Karin M. PMID: 20420949.
      View in: PubMed   Mentions: 931     Fields:    Translation:HumansAnimalsCells
    243. Sestrins at the crossroad between stress and aging. Aging (Albany NY). 2010 Jun; 2(6):369-74. Lee JH, Bodmer R, Bier E, Karin M. PMID: 20606249; PMCID: PMC2919257.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    244. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. Int Immunopharmacol. 2010 Aug; 10(8):906-12. Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. PMID: 20494824; PMCID: PMC2908188.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    245. Cancer and inflammation: promise for biologic therapy. J Immunother. 2010 May; 33(4):335-51. Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, Abraham RT, Carbone M, Lotze MT. PMID: 20386472; PMCID: PMC2941912.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimals
    246. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J. 2010 Aug; 24(8):2596-611. Solinas G, Karin M. PMID: 20371626.
      View in: PubMed   Mentions: 138     Fields:    Translation:Humans
    247. Immunity, inflammation, and cancer. Cell. 2010 Mar 19; 140(6):883-99. Grivennikov SI, Greten FR, Karin M. PMID: 20303878; PMCID: PMC2866629.
      View in: PubMed   Mentions: 4799     Fields:    Translation:HumansAnimals
    248. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010 Mar 16; 17(3):286-97. He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. PMID: 20227042; PMCID: PMC2841312.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansAnimalsCells
    249. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 2010 Mar 11; 464(7286):302-5. Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. PMID: 20220849; PMCID: PMC2866639.
      View in: PubMed   Mentions: 317     Fields:    Translation:HumansAnimalsCells
    250. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 05; 327(5970):1223-8. Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. PMID: 20203043; PMCID: PMC2866632.
      View in: PubMed   Mentions: 289     Fields:    Translation:AnimalsCells
    251. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010 Jan 22; 140(2):197-208. Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. PMID: 20141834; PMCID: PMC2836922.
      View in: PubMed   Mentions: 817     Fields:    Translation:Animals
    252. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-9715. Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. PMID: 20097762; PMCID: PMC2843220.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    253. Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. Cancer Cell. 2010 Jan 19; 17(1):89-97. Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M. PMID: 20129250; PMCID: PMC2818776.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsPHPublic Health
    254. Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev. 2010 Feb; 20(1):65-71. Grivennikov SI, Karin M. PMID: 20036794; PMCID: PMC2821983.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansCells
    255. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010 Feb; 21(1):11-9. Grivennikov SI, Karin M. PMID: 20018552; PMCID: PMC2834864.
      View in: PubMed   Mentions: 544     Fields:    Translation:HumansAnimalsCells
    256. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. J Immunol. 2009 Dec 15; 183(12):7877-89. Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. PMID: 20007573; PMCID: PMC4095798.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    257. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 2010 Mar; 138(3):1022-34.e1-10. Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. PMID: 19962981; PMCID: PMC2831162.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    258. Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology. 2009 Dec; 50(6):1851-60. Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. PMID: 19821485.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    259. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. PMID: 19950258; PMCID: PMC2847793.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    260. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010 Jan; 11(1):70-5. Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. PMID: 19898473; PMCID: PMC2872790.
      View in: PubMed   Mentions: 205     Fields:    Translation:AnimalsCells
    261. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a000141. Karin M. PMID: 20066113; PMCID: PMC2773649.
      View in: PubMed   Mentions: 406     Fields:    Translation:HumansAnimalsCells
    262. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 06; 16(4):295-308. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. PMID: 19800575; PMCID: PMC4422166.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    263. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 2009 Nov 12; 114(20):4469-76. Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. PMID: 19755673.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    264. MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol. 2009 Sep 15; 183(6):3831-8. Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. PMID: 19710465.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    265. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009 Aug 19; 4(8):e6695. Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. PMID: 19690611; PMCID: PMC2723911.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    266. NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12873-8. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L. PMID: 19541630; PMCID: PMC2722361.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    267. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784; PMCID: PMC2688966.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    268. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunol Rev. 2009 Mar; 228(1):225-40. Karin M, Gallagher E. PMID: 19290931.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    269. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 2009 Feb 06; 136(3):565. Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. PMID: 19203587.
      View in: PubMed   Mentions:    Fields:    
    270. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. PMID: 19185845; PMCID: PMC2667107.
      View in: PubMed   Mentions: 1052     Fields:    Translation:HumansAnimalsCells
    271. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):349-54. Koch KS, Maeda S, He G, Karin M, Leffert HL. PMID: 19171122; PMCID: PMC2663043.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    272. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009 Jan; 8(1):33-40. Baud V, Karin M. PMID: 19116625; PMCID: PMC2729321.
      View in: PubMed   Mentions: 485     Fields:    Translation:HumansAnimalsCells
    273. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 2009 Jan 01; 457(7225):102-6. Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M. PMID: 19122641; PMCID: PMC2746432.
      View in: PubMed   Mentions: 541     Fields:    Translation:AnimalsCells
    274. Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733. Vallabhapurapu S, Karin M. PMID: 19302050.
      View in: PubMed   Mentions: 1213     Fields:    Translation:HumansAnimalsCells
    275. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20197-202. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholson TP, Sheppard PW, Häcker H, Karin M, Vignali DA. PMID: 19091944; PMCID: PMC2629300.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    276. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem. 2009 Jan 09; 284(2):862-71. Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. PMID: 19001420; PMCID: PMC2613605.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    277. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol. 2008 Dec; 9(12):1364-70. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. PMID: 18997792; PMCID: PMC2671996.
      View in: PubMed   Mentions: 331     Fields:    Translation:HumansAnimalsCells
    278. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17091-6. Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. PMID: 18957551; PMCID: PMC2579383.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    279. NF-kappaB signaling, liver disease and hepatoprotective agents. Oncogene. 2008 Oct 20; 27(48):6228-44. Sun B, Karin M. PMID: 18931690.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    280. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16809-13. Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. PMID: 18922779; PMCID: PMC2567907.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    281. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008 Oct 03; 135(1):61-73. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. PMID: 18854155; PMCID: PMC2586330.
      View in: PubMed   Mentions: 613     Fields:    Translation:HumansAnimalsCells
    282. Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Dev Dyn. 2008 Oct; 237(10):2926-35. Hou Y, Li F, Karin M, Ostrowski MC. PMID: 18816823; PMCID: PMC2998709.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    283. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain. 2008 Nov; 131(Pt 11):3019-33. Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ. PMID: 18819987; PMCID: PMC2577806.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    284. IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J. 2008 Oct 22; 27(20):2639-47. Descargues P, Sil AK, Karin M. PMID: 18818691; PMCID: PMC2556095.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    285. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15058-63. Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. PMID: 18815378; PMCID: PMC2567492.
      View in: PubMed   Mentions: 88     Fields:    Translation:Animals
    286. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 2008 Aug 12; 14(2):156-65. Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. PMID: 18691550; PMCID: PMC2707922.
      View in: PubMed   Mentions: 241     Fields:    Translation:AnimalsCells
    287. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 2008 Aug 08; 134(3):451-60. Budanov AV, Karin M. PMID: 18692468; PMCID: PMC2758522.
      View in: PubMed   Mentions: 686     Fields:    Translation:HumansAnimalsCells
    288. Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One. 2008 Jul 23; 3(7):e2769. Meinzer U, Esmiol-Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, Chareyre F, Niwa-Kawakita M, Alberti C, Sterkers G, Villard C, Lesuffleur T, Peuchmaur M, Karin M, Eckmann L, Giovannini M, Ollendorff V, Wolf-Watz H, Hugot JP. PMID: 18648508; PMCID: PMC2447872.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    289. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. J Invest Dermatol. 2009 Jan; 129(1):60-9. Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. PMID: 18633439.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    290. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008 Aug 01; 321(5889):663-8. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. PMID: 18635759; PMCID: PMC2669719.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    291. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008 Oct; 135(4):1311-21. Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M. PMID: 18700144.
      View in: PubMed   Mentions: 129     Fields:    Translation:AnimalsCells
    292. The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 2008 Jul 08; 14(1):10-21. Bernassola F, Karin M, Ciechanover A, Melino G. PMID: 18598940.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimalsCells
    293. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 2008 Jul 01; 68(13):5031-9. Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. PMID: 18593901.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    294. Prion propagation in mice lacking central nervous system NF-kappaB signalling. J Gen Virol. 2008 Jun; 89(Pt 6):1545-1550. Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A. PMID: 18474572.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    295. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7803-8. Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. PMID: 18511561; PMCID: PMC2409384.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    296. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. J Exp Med. 2008 Jun 09; 205(6):1269-76. Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. PMID: 18490491; PMCID: PMC2413025.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    297. NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev. 2008 Feb; 18(1):19-26. Naugler WE, Karin M. PMID: 18440219; PMCID: PMC2587362.
      View in: PubMed   Mentions: 302     Fields:    Translation:HumansCells
    298. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192; PMCID: PMC2669289.
      View in: PubMed   Mentions: 690     Fields:    Translation:AnimalsCells
    299. The IkappaB kinase - a bridge between inflammation and cancer. Cell Res. 2008 Mar; 18(3):334-42. Karin M. PMID: 18301380.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimals
    300. Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response. Mol Cell. 2008 Feb 15; 29(3):279-90. Herrlich P, Karin M, Weiss C. PMID: 18280234; PMCID: PMC2714880.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    301. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2487-92. Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M. PMID: 18268325; PMCID: PMC2268163.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    302. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med. 2008 Mar; 14(3):109-19. Naugler WE, Karin M. PMID: 18261959.
      View in: PubMed   Mentions: 302     Fields:    Translation:HumansAnimalsCells
    303. Autocrine IL-6 signaling: a key event in tumorigenesis? Cancer Cell. 2008 Jan; 13(1):7-9. Grivennikov S, Karin M. PMID: 18167335.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    304. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev. 2007 Dec; 220:8-21. Temkin V, Karin M. PMID: 17979836.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    305. Rsk Tolls the bell for endocytosis in DCs. Nat Immunol. 2007 Nov; 8(11):1197-9. Karin M. PMID: 17952046.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    306. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007 Nov; 6(5):386-97. Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. PMID: 17983584.
      View in: PubMed   Mentions: 263     Fields:    Translation:AnimalsCells
    307. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 2007 Oct 30; 46(43):12482-90. Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. PMID: 17924664.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    308. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15852-7. Cao Y, Luo JL, Karin M. PMID: 17890319; PMCID: PMC2000410.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    309. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007 Sep 07; 130(5):918-31. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. PMID: 17803913; PMCID: PMC2134986.
      View in: PubMed   Mentions: 318     Fields:    Translation:HumansAnimalsCells
    310. Inhibitor-kappaB kinase in tumor promotion and suppression during progression of squamous cell carcinoma. Clin Cancer Res. 2007 Sep 01; 13(17):4956-9. Van Waes C, Yu M, Nottingham L, Karin M. PMID: 17785544.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    311. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 Jul 06; 317(5834):121-4. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M. PMID: 17615358.
      View in: PubMed   Mentions: 871     Fields:    Translation:AnimalsCells
    312. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Crit Care Med. 2007 May; 35(5):1332-40. Chen LW, Chen PH, Chang WJ, Wang JS, Karin M, Hsu CM. PMID: 17414734.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    313. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007 May; 117(5):1175-83. Lin WW, Karin M. PMID: 17476347; PMCID: PMC1857251.
      View in: PubMed   Mentions: 741     Fields:    Translation:HumansAnimals
    314. Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6359-64. Mills DM, Bonizzi G, Karin M, Rickert RC. PMID: 17404218; PMCID: PMC1851084.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    315. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. PMID: 17380205; PMCID: PMC1821069.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    316. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 2007 Apr 05; 446(7136):690-4. Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. PMID: 17377533.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    317. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007 Mar 29; 446(7135):552-6. Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. PMID: 17322906.
      View in: PubMed   Mentions: 226     Fields:    Translation:AnimalsCells
    318. p63 induces key target genes required for epidermal morphogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3255-60. Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. PMID: 17360634; PMCID: PMC1805532.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    319. NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):1913-8. Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. PMID: 17267600; PMCID: PMC1794308.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    320. Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Adv Exp Med Biol. 2007; 602:125-34. Ruocco MG, Karin M. PMID: 17966397.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    321. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metab Dispos. 2007 Mar; 35(3):402-9. Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ. PMID: 17151194.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    322. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol. 2007 Jan; 8(1):57-63. Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. PMID: 17143273.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    323. Role for IKK2 in muscle: waste not, want not. J Clin Invest. 2006 Nov; 116(11):2866-8. Karin M. PMID: 17080193; PMCID: PMC1626137.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    324. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. J Immunol. 2006 Nov 01; 177(9):6344-52. Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. PMID: 17056565.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    325. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16454-9. Solinas G, Naugler W, Galimi F, Lee MS, Karin M. PMID: 17050683; PMCID: PMC1637603.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    326. Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006 Oct 17; 2006(357):re13. Häcker H, Karin M. PMID: 17047224.
      View in: PubMed   Mentions: 602     Fields:    Translation:HumansAnimalsCells
    327. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007 Jan 15; 109(2):703-10. Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. PMID: 16973958; PMCID: PMC1890820.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    328. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. J Biol Chem. 2006 Dec 01; 281(48):37142-9. Chen F, Lu Y, Castranova V, Li Z, Karin M. PMID: 16966325.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    329. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15. Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. PMID: 16973390.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    330. MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. Eur J Immunol. 2006 Aug; 36(8):2076-84. Labuda T, Christensen JP, Rasmussen S, Bonnesen B, Karin M, Thomsen AR, Odum N. PMID: 16761309.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    331. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007 Feb 08; 26(6):851-8. Lin R, Maeda S, Liu C, Karin M, Edgington TS. PMID: 16878148.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansAnimalsCells
    332. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J Immunol. 2006 Jul 15; 177(2):1214-20. Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. PMID: 16818780.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    333. Intracellular pattern recognition receptors in the host response. Nature. 2006 Jul 06; 442(7098):39-44. Meylan E, Tschopp J, Karin M. PMID: 16823444.
      View in: PubMed   Mentions: 440     Fields:    Translation:HumansAnimals
    334. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10741-6. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. PMID: 16818881; PMCID: PMC1487172.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    335. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A. 2006 Jul 11; 103(28):10544-51. Sakurai T, Maeda S, Chang L, Karin M. PMID: 16807293; PMCID: PMC1502270.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
    336. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun; 45(6):355-61. Karin M. PMID: 16673382.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    337. Nuclear factor-kappaB in cancer development and progression. Nature. 2006 May 25; 441(7092):431-6. Karin M. PMID: 16724054.
      View in: PubMed   Mentions: 1520     Fields:    Translation:HumansAnimals
    338. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem. 2006 Jul 28; 281(30):21458-21468. Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. PMID: 16717090.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    339. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest. 2006 Apr; 116(4):1117-26. Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. PMID: 16557301; PMCID: PMC1409741.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    340. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24; 124(4):823-35. Karin M, Lawrence T, Nizet V. PMID: 16497591.
      View in: PubMed   Mentions: 371     Fields:    Translation:HumansAnimalsCells
    341. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006 Feb 10; 124(3):601-13. Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. PMID: 16469705.
      View in: PubMed   Mentions: 322     Fields:    Translation:AnimalsCells
    342. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2292-7. Mahieu T, Park JM, Revets H, Pasche B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. PMID: 16455798; PMCID: PMC1413734.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    343. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3244-9. Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. PMID: 16455799; PMCID: PMC1413899.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    344. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1717-22. Gallagher E, Gao M, Liu YC, Karin M. PMID: 16446428; PMCID: PMC1413664.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCells
    345. Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lect. 2006-2007; 102:133-51. Karin M. PMID: 20166567.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    346. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005 Dec 22; 20(6):891-903. Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R. PMID: 16364914.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    347. Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 2005 Dec; 5(12):941-52. Liu YC, Penninger J, Karin M. PMID: 16322747; PMCID: PMC7096784.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    348. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17723-8. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. PMID: 16317067; PMCID: PMC1308936.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    349. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006 Jan 12; 439(7073):204-7. Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. PMID: 16306937.
      View in: PubMed   Mentions: 388     Fields:    Translation:AnimalsCells
    350. The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol. 2005 Nov; 25(6):541-50. Luo JL, Kamata H, Karin M. PMID: 16380818.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    351. IKK{beta} as a target for treatment of inflammation induced bone loss. Ann Rheum Dis. 2005 Nov; 64 Suppl 4:iv81-5. Ruocco MG, Karin M. PMID: 16239395; PMCID: PMC1766902.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    352. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005 Oct; 5(10):749-59. Karin M, Greten FR. PMID: 16175180.
      View in: PubMed   Mentions: 1254     Fields:    Translation:HumansAnimalsCells
    353. IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. J Clin Invest. 2005 Oct; 115(10):2625-32. Luo JL, Kamata H, Karin M. PMID: 16200195; PMCID: PMC1236696.
      View in: PubMed   Mentions: 330     Fields:    Translation:HumansAnimalsCells
    354. Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell. 2005 Sep 02; 19(5):581-93. Gao M, Karin M. PMID: 16137616.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    355. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 2005 Sep; 23(3):319-29. Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. PMID: 16169504.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    356. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005 Jul 01; 121(7):977-90. Maeda S, Kamata H, Luo JL, Leffert H, Karin M. PMID: 15989949.
      View in: PubMed   Mentions: 537     Fields:    Translation:AnimalsCells
    357. NOD2 and Crohn's disease: loss or gain of function? Immunity. 2005 Jun; 22(6):661-7. Eckmann L, Karin M. PMID: 15963781.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    358. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. EMBO Rep. 2005 Jun; 6(6):531-7. Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Chuang T, Tuthill C, Wan Y, Karin M, Chu WM. PMID: 15905851; PMCID: PMC1369095.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    359. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005 May 16; 201(10):1677-87. Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. PMID: 15897281; PMCID: PMC2212920.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    360. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 2005 Apr 28; 434(7037):1138-43. Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. PMID: 15858576.
      View in: PubMed   Mentions: 283     Fields:    Translation:AnimalsCells
    361. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life. 2005 Apr-May; 57(4-5):283-95. Karin M, Gallagher E. PMID: 16036612.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    362. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11; 120(5):649-61. Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. PMID: 15766528.
      View in: PubMed   Mentions: 742     Fields:    Translation:HumansAnimalsCells
    363. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 04; 307(5710):734-8. Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. PMID: 15692052.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    364. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005 Feb; 11(2):191-8. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. PMID: 15685170.
      View in: PubMed   Mentions: 773     Fields:    Translation:AnimalsCells
    365. Inflammation-activated protein kinases as targets for drug development. Proc Am Thorac Soc. 2005; 2(4):386-90; discussion 394-5. Karin M. PMID: 16267367; PMCID: PMC2713329.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    366. Inflammation and cancer: the long reach of Ras. Nat Med. 2005 Jan; 11(1):20-1. Karin M. PMID: 15635437.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    367. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004 Dec 20; 200(12):1647-55. Park JM, Ng VH, Maeda S, Rest RF, Karin M. PMID: 15611291; PMCID: PMC2211988.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    368. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17813-8. Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. PMID: 15601766; PMCID: PMC539759.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    369. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. J Immunol. 2004 Nov 15; 173(10):6161-8. Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH. PMID: 15528353.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    370. Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Ann Rheum Dis. 2004 Nov; 63 Suppl 2:ii62-ii64. Karin M. PMID: 15479874; PMCID: PMC1766783.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    371. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J. 2004 Oct 27; 23(21):4202-10. Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. PMID: 15470505; PMCID: PMC524385.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    372. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell. 2004 Sep 10; 15(5):713-25. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. PMID: 15350216.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
    373. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science. 2004 Oct 08; 306(5694):271-5. Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. PMID: 15358865.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    374. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 2004 Sep; 6(3):297-305. Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. PMID: 15380520.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
    375. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 2004 Aug 06; 118(3):285-96. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. PMID: 15294155.
      View in: PubMed   Mentions: 1069     Fields:    Translation:AnimalsCells
    376. CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. J Neuroimmunol. 2004 Aug; 153(1-2):50-63. Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ. PMID: 15265663.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    377. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Mol Cell Biol. 2004 Jul; 24(13):5914-22. Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG. PMID: 15199146; PMCID: PMC480890.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    378. Genetic dissection of antigen receptor induced-NF-kappaB activation. Mol Immunol. 2004 Jul; 41(6-7):701-14. Li ZW, Rickert RC, Karin M. PMID: 15220005.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    379. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell. 2004 Jun 04; 14(5):571-83. Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY. PMID: 15175153.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansCells
    380. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004 Jun; 25(6):280-8. Bonizzi G, Karin M. PMID: 15145317.
      View in: PubMed   Mentions: 951     Fields:    Translation:AnimalsCells
    381. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett. 2004 Apr 08; 206(2):193-9. Greten FR, Karin M. PMID: 15013524.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    382. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 2004 Apr 08; 428(6983):660-4. Sil AK, Maeda S, Sano Y, Roop DR, Karin M. PMID: 15071597.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    383. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 2004 Apr 01; 23(14):2540-7. Amir RE, Haecker H, Karin M, Ciechanover A. PMID: 14676825.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    384. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. J Biol Chem. 2004 Jun 04; 279(23):23969-76. Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. PMID: 15037607.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    385. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 2004 Mar 18; 428(6980):341-5. Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. PMID: 15029200.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    386. Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Dev. 2004 Mar 01; 18(5):584-94. Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. PMID: 15037551; PMCID: PMC374239.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    387. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2452-7. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. PMID: 14983030; PMCID: PMC356971.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    388. A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb; 6(2):219-27. Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT. PMID: 14960276.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    389. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 2004 Feb; 14(2):94-101. Xia Y, Karin M. PMID: 15102441.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    390. The IKK NF-kappa B system: a treasure trove for drug development. Nat Rev Drug Discov. 2004 Jan; 3(1):17-26. Karin M, Yamamoto Y, Wang QM. PMID: 14708018.
      View in: PubMed   Mentions: 442     Fields:    Translation:HumansAnimalsCells
    391. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res. 2003 Nov 15; 63(22):7689-93. Chen F, Castranova V, Li Z, Karin M, Shi X. PMID: 14633691.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    392. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov; 23(21):7780-93. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. PMID: 14560022; PMCID: PMC207563.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    393. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 2003 Nov; 19(5):725-37. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. PMID: 14614859.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    394. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell. 2003 Oct; 12(4):829-39. Kato T, Delhase M, Hoffmann A, Karin M. PMID: 14580335.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansCells
    395. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 2003 Sep 01; 22(17):4443-54. Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. PMID: 12941696; PMCID: PMC202382.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    396. Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J. 2003 Jul 01; 22(13):3356-66. Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. PMID: 12839997; PMCID: PMC165656.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    397. Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003 May; 51(5):555-65. Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L. PMID: 12704203.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    398. IKK beta is required for peripheral B cell survival and proliferation. J Immunol. 2003 May 01; 170(9):4630-7. Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. PMID: 12707341.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    399. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003 May; 9(5):575-81. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. PMID: 12692538.
      View in: PubMed   Mentions: 188     Fields:    Translation:Animals
    400. NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):215-23. Cao Y, Karin M. PMID: 14635796.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    401. NF-kappaB in cancer: a marked target. Semin Cancer Biol. 2003 Apr; 13(2):107-14. Lin A, Karin M. PMID: 12654254.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    402. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell. 2003 Apr; 4(4):521-33. Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. PMID: 12689591.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCells
    403. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. J Biol Chem. 2003 May 23; 278(21):19526-33. Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. PMID: 12637498.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    404. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Mol Cell Biol. 2003 Feb; 23(3):1061-74. Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. PMID: 12529410; PMCID: PMC140693.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    405. Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 2003 Feb; 3(2):102-4. Maeda S, Karin M. PMID: 12620404.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    406. The control of mRNA stability in response to extracellular stimuli. Mol Cells. 2002 Dec 31; 14(3):323-31. Shim J, Karin M. PMID: 12521293.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    407. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2002 Dec; 2(6):431-3. Häcker H, Karin M. PMID: 12498710.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    408. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell. 2002 Dec; 10(6):1331-44. Shim J, Lim H, R Yates J, Karin M. PMID: 12504009.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    409. A central role for JNK in obesity and insulin resistance. Nature. 2002 Nov 21; 420(6913):333-6. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. PMID: 12447443.
      View in: PubMed   Mentions: 1252     Fields:    Translation:AnimalsCells
    410. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002 Oct; 17(4):525-35. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. PMID: 12387745.
      View in: PubMed   Mentions: 365     Fields:    Translation:HumansAnimalsCells
    411. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem. 2002 Oct 04; 277(40):37896-903. Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. PMID: 12138127.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    412. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002 May; 4(5):E131-6. Shaulian E, Karin M. PMID: 11988758.
      View in: PubMed   Mentions: 1025     Fields:    Translation:AnimalsCells
    413. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1631-5. Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. PMID: 11980884.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    414. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002 Apr; 2(4):301-10. Karin M, Cao Y, Greten FR, Li ZW. PMID: 12001991.
      View in: PubMed   Mentions: 913     Fields:    Translation:HumansAnimalsCells
    415. Missing pieces in the NF-kappaB puzzle. Cell. 2002 Apr; 109 Suppl:S81-96. Ghosh S, Karin M. PMID: 11983155.
      View in: PubMed   Mentions: 1224     Fields:    Translation:HumansAnimalsCells
    416. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002 Mar; 3(3):221-7. Karin M, Lin A. PMID: 11875461.
      View in: PubMed   Mentions: 918     Fields:    Translation:HumansAnimals
    417. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum. 2002 Mar; 46(3):818-23. Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. PMID: 11920420.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    418. The IKK/NF-kappa B pathway. Crit Care Med. 2002 Jan; 30(1 Suppl):S18-26. Senftleben U, Karin M. PMID: 11782557.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    419. The IKK/NF-kappaB pathway. Crit Care Med. 2002 Jan; 30(1 Supp):S18-S26. Senftleben U, Karin M. PMID: 11891403.
      View in: PubMed   Mentions: 36     Fields:    
    420. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001 Dec 14; 107(6):763-75. Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. PMID: 11747812.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    421. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell. 2001 Nov 16; 107(4):451-64. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M. PMID: 11719186.
      View in: PubMed   Mentions: 383     Fields:    Translation:HumansAnimalsCells
    422. Inhibition of JNK activation through NF-kappaB target genes. Nature. 2001 Nov 15; 414(6861):313-7. Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. PMID: 11713531.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimalsCells
    423. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science. 2001 Aug 24; 293(5534):1495-9. Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. PMID: 11520989.
      View in: PubMed   Mentions: 534     Fields:    Translation:AnimalsCells
    424. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul; 108(1):73-81. Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. PMID: 11435459; PMCID: PMC209341.
      View in: PubMed   Mentions: 241     Fields:    Translation:AnimalsCells
    425. AP-1: linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death. IUBMB Life. 2001 Jul; 52(1-2):17-24. Karin M, Shaulian E. PMID: 11795587.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    426. c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene. 2001 Jun 07; 20(26):3443-8. Jiménez B, Volpert OV, Reiher F, Chang L, Muñoz A, Karin M, Bouck N. PMID: 11423995.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    427. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol Cell Biol. 2001 Jun; 21(12):3986-94. Devin A, Lin Y, Yamaoka S, Li Z, Karin M. PMID: 11359906; PMCID: PMC87061.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    428. AP-1--glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol. 2001 Jun; 169(3):447-51. Karin M, Chang L. PMID: 11375114.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    429. AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation. Mol Cell Biol. 2001 May; 21(9):3012-24. Piu F, Aronheim A, Katz S, Karin M. PMID: 11287607; PMCID: PMC86930.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    430. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol. 2001 May 01; 209(2):149-57. Ojo-Amaize EA, Kapahi P, Kakkanaiah VN, Takahashi T, Shalom-Barak T, Cottam HB, Adesomoju AA, Nchekwube EJ, Oyemade OA, Karin M, Okogun JI. PMID: 11446747.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    431. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 2001 Apr 05; 410(6829):710-4. Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. PMID: 11287960.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    432. IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Immunity. 2001 Mar; 14(3):217-30. Senftleben U, Li ZW, Baud V, Karin M. PMID: 11290332.