James La Clair

Title(s)Project Scientist, Chemistry and Biochemistry
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Advance of Seriniquinone Analogues as Melanoma Agents. ACS Med Chem Lett. 2019 Feb 14; 10(2):186-190. Hammons JC, Trzoss L, Jimenez PC, Hirata AS, Costa-Lotufo LV, La Clair JJ, Fenical W. PMID: 30783501; PMCID: PMC6378664.
      View in: PubMed   Mentions: 7  
    2. Trapping the Complex Molecular Machinery of Polyketide and Fatty Acid Synthases with Tunable Silylcyanohydrin Crosslinkers. Angew Chem Int Ed Engl. 2018 12 21; 57(52):17009-17013. Konno S, La Clair JJ, Burkart MD. PMID: 30379389; PMCID: PMC6407627.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    3. Daedal Facets of Splice Modulator Optimization. ACS Med Chem Lett. 2018 Nov 08; 9(11):1070-1072. Chan WC, León B, Krug KA, Patel A, La Clair JJ, Burkart MD. PMID: 30429946; PMCID: PMC6231189.
      View in: PubMed   Mentions: 1  
    4. Metabolic and Biosynthetic Diversity in Marine Myxobacteria. Mar Drugs. 2018 Sep 05; 16(9). Gemperlein K, Zaburannyi N, Garcia R, La Clair JJ, Müller R. PMID: 30189599; PMCID: PMC6163206.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    5. Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics. Mar Drugs. 2018 Aug 29; 16(9). Garcia R, La Clair JJ, Müller R. PMID: 30158489; PMCID: PMC6163921.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    6. Correction: Encoding matter with regiospecific 12C/13C isotopic labels. Chem Commun (Camb). 2018 04 03; 54(28):3543. La Clair JJ. PMID: 29578218.
      View in: PubMed   Mentions:    Fields:    
    7. Encoding matter with regiospecific 12C/13C isotopic labels. Chem Commun (Camb). 2018 Mar 08; 54(21):2611-2614. La Clair JJ. PMID: 29417122.
      View in: PubMed   Mentions: 4     Fields:    
    8. Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Nat Prod Rep. 2017 08 30; 34(9):1051-1060. Kornienko A, La Clair JJ. PMID: 28808718; PMCID: PMC5759776.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    9. A Challenging Pie to Splice: Drugging the Spliceosome. Angew Chem Int Ed Engl. 2017 09 25; 56(40):12052-12063. León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart MD. PMID: 28371109; PMCID: PMC6311392.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    10. Irreversible Protein Labeling by Paal-Knorr Conjugation. Chembiochem. 2017 09 19; 18(18):1792-1796. Dasari R, La Clair JJ, Kornienko A. PMID: 28715110; PMCID: PMC5766258.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4142-E4148. Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. PMID: 28484029; PMCID: PMC5448209.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    12. Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2563-E2570. Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. PMID: 28320959; PMCID: PMC5380080.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    13. Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog. 2017 05; 56(5):1493-1500. Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. PMID: 28019675; PMCID: PMC5404829.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    14. Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem. 2017 03 16; 18(6):506-510. Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. PMID: 28074539; PMCID: PMC5562448.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. PMID: 27570067; PMCID: PMC5097015.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    16. Single dish gradient screening of small molecule localization. Org Biomol Chem. 2016 Sep 21; 14(35):8241-5. Beuzer P, Axelrod J, Trzoss L, Fenical W, Dasari R, Evidente A, Kornienko A, Cang H, La Clair JJ. PMID: 27530345; PMCID: PMC5284121.
      View in: PubMed   Mentions: 3     Fields:    
    17. Selectivity in Small Molecule Splicing Modulation. ACS Chem Biol. 2016 10 21; 11(10):2716-2723. Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. PMID: 27499047.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity. Chembiochem. 2016 09 02; 17(17):1598-601. McCulloch IP, La Clair JJ, Jaremko MJ, Burkart MD. PMID: 27271974; PMCID: PMC5656434.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    19. An unusual intramolecular trans-amidation. Tetrahedron. 2016 Jun 23; 72(25):3605-3608. Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart MD. PMID: 27346894; PMCID: PMC4917018.
      View in: PubMed   Mentions:    Fields:    
    20. Color-Coded Super-Resolution Small-Molecule Imaging. Chembiochem. 2016 06 02; 17(11):999-1003. Beuzer P, La Clair JJ, Cang H. PMID: 26994590; PMCID: PMC5291120.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. A Carbohydrate-Derived Splice Modulator. J Am Chem Soc. 2016 Apr 20; 138(15):5063-8. Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart MD. PMID: 27058259.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. De Novo Asymmetric Synthesis and Biological Analysis of the Daumone Pheromones in Caenorhabditis elegans and in the Soybean Cyst Nematode Heterodera glycines. Tetrahedron. 2016 May 05; 72(18):2280-2286. Guo H, La Clair JJ, Masler EP, O'Doherty G, Xing Y. PMID: 29445247; PMCID: PMC5809136.
      View in: PubMed   Mentions: 2     Fields:    
    23. Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction. J Am Chem Soc. 2016 Mar 30; 138(12):3962-5. Tallorin L, Finzel K, Nguyen QG, Beld J, La Clair JJ, Burkart MD. PMID: 26938266; PMCID: PMC4988885.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    24. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol. 2016 04; 31:66-73. Vickery CR, La Clair JJ, Burkart MD, Noel JP. PMID: 26851514; PMCID: PMC5217535.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    25. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem. 2015 Sep 21; 16(14):2002-6. Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. PMID: 26267855; PMCID: PMC4835225.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging. Life Sci. 2015 Sep 01; 136:163-7. Rocha DD, Espejo VR, Rainier JD, La Clair JJ, Costa-Lotufo LV. PMID: 26141988.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus. J Nat Prod. 2015 May 22; 78(5):996-1004. Santos EA, Quintela AL, Ferreira EG, Sousa TS, Pinto Fd, Hajdu E, Carvalho MS, Salani S, Rocha DD, Wilke DV, Torres Mda C, Jimenez PC, Silveira ER, La Clair JJ, Pessoa OD, Costa-Lotufo LV. PMID: 25879576.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica. 2015 Jul; 100(7):945-54. Kashyap MK, Kumar D, Villa R, La Clair JJ, Benner C, Sasik R, Jones H, Ghia EM, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. PMID: 25862704; PMCID: PMC4486229.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    29. Correction: Chapman, E.; et al. Inhibitors of the AAA+ chaperone p97. Molecules 2015, 20, 3027-3049. Molecules. 2015 Mar 09; 20(3):4357-8. Chapman E, Maksim N, de la Cruz F, La Clair JJ. PMID: 25759952; PMCID: PMC4687487.
      View in: PubMed   Mentions: 1     Fields:    
    30. Functional chromatographic technique for natural product isolation. Org Biomol Chem. 2015 Feb 28; 13(8):2255-9. Lau EC, Mason DJ, Eichhorst N, Engelder P, Mesa C, Kithsiri Wijeratne EM, Gunaherath GM, Gunatilaka AA, La Clair JJ, Chapman E. PMID: 25588099; PMCID: PMC4576851.
      View in: PubMed   Mentions: 6     Fields:    
    31. Inhibitors of the AAA+ chaperone p97. Molecules. 2015 Feb 12; 20(2):3027-49. Chapman E, Maksim N, de la Cruz F, La Clair JJ. PMID: 25685910; PMCID: PMC4576884.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    32. Modeling linear and cyclic PKS intermediates through atom replacement. J Am Chem Soc. 2014 Dec 03; 136(48):16792-9. Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD. PMID: 25406716; PMCID: PMC4277753.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    33. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14687-92. Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W. PMID: 25271322; PMCID: PMC4205641.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    34. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem. 2014 Sep 22; 15(14):2125-31. Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. PMID: 25125376; PMCID: PMC4187115.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    35. In situ natural product discovery via an artificial marine sponge. PLoS One. 2014; 9(7):e100474. La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P. PMID: 25004127; PMCID: PMC4086721.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    36. Identification of pyrroloformamide as a cytokinesis modulator. Chembiochem. 2014 Mar 03; 15(4):501-6. Abreu PA, Sousa TS, Jimenez PC, Wilke DV, Rocha DD, Freitas HP, Pessoa OD, La Clair JJ, Costa-Lotufo LV. PMID: 24478218.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    37. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94. Org Biomol Chem. 2014 Jan 21; 12(3):418-23. Farnaes L, La Clair JJ, Fenical W. PMID: 24292715; PMCID: PMC3893886.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    38. Pharmacokinetics, metabolism, and in vivo efficacy of the antimalarial natural product bromophycolide A. ACS Med Chem Lett. 2013 Oct 10; 4(10):989-993. Teasdale ME, Prudhomme J, Torres M, Braley M, Cervantes S, Bhatia SC, La Clair JJ, Le Roch K, Kubanek J. PMID: 24159368; PMCID: PMC3804352.
      View in: PubMed   Mentions: 4  
    39. Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J Med Chem. 2013 Sep 12; 56(17):6576-82. Villa R, Kashyap MK, Kumar D, Kipps TJ, Castro JE, La Clair JJ, Burkart MD. PMID: 23919277; PMCID: PMC3809018.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    40. Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF). J Nat Prod. 2013 May 24; 76(5):817-23. Yu WL, Jones BD, Kang M, Hammons JC, La Clair JJ, Burkart MD. PMID: 23659282; PMCID: PMC3706094.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    41. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem. 2013 May 27; 14(8):950-3. Lipson JM, Thomsen M, Moore BS, Clausen RP, La Clair JJ, Burkart MD. PMID: 23650044; PMCID: PMC3749784.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    42. Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8284-9. Guo Y, Zheng Z, La Clair JJ, Chory J, Noel JP. PMID: 23613584; PMCID: PMC3657771.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    43. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24; 135(16):5962-5. Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. PMID: 23550886; PMCID: PMC3657554.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    44. Palyosulfonoceramides A and B: unique sulfonylated ceramides from the Brazilian zoanthids Palythoa caribaeorum and Protopalythoa variabilis. Mar Drugs. 2012 Dec 14; 10(12):2846-60. Almeida JG, Maia AI, Wilke DV, Silveira ER, Braz-Filho R, La Clair JJ, Costa-Lotufo LV, Pessoa OD. PMID: 23242205; PMCID: PMC3528130.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    45. Structure of FD-895 revealed through total synthesis. Org Lett. 2012 Nov 02; 14(21):5396-9. Villa R, Mandel AL, Jones BD, La Clair JJ, Burkart MD. PMID: 23072504; PMCID: PMC3518397.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    46. Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae. J Nat Prod. 2011 Oct 28; 74(10):2045-51. La Clair JJ, Rheingold AL, Burkart MD. PMID: 21939217.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    47. Synthesis and evaluation of a fluorescent ritterazine-cephalostatin hybrid. Org Lett. 2011 Oct 07; 13(19):5334-7. Kumar KA, La Clair JJ, Fuchs PL. PMID: 21913733; PMCID: PMC3264888.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. Chemical and Chemoenzymatic syntheses of bacillithiol: a unique low-molecular-weight thiol amongst low G + C Gram-positive bacteria. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7101-4. Sharma SV, Jothivasan VK, Newton GL, Upton H, Wakabayashi JI, Kane MG, Roberts AA, Rawat M, La Clair JJ, Hamilton CJ. PMID: 21751306.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    49. Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1). Angew Chem Int Ed Engl. 2011 Aug 22; 50(35):8134-8. Vera B, Rodríguez AD, La Clair JJ. PMID: 21744448; PMCID: PMC3582901.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    50. Bromophycolide A targets heme crystallization in the human malaria parasite Plasmodium falciparum. ChemMedChem. 2011 Sep 05; 6(9):1572-7. Stout EP, Cervantes S, Prudhomme J, France S, La Clair JJ, Le Roch K, Kubanek J. PMID: 21732541; PMCID: PMC3381860.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. Isolation of the β-galactosphingolipid coniferoside using a tumor cell proteome reverse affinity protocol. Bioorg Med Chem. 2011 Nov 15; 19(22):6645-53. La Clair JJ, Rodríguez AD. PMID: 21784648.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. Newton GL, Buchmeier N, La Clair JJ, Fahey RC. PMID: 21665483; PMCID: PMC3123436.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Convergent route to the spirohexenolide macrocycle. Org Lett. 2010 Oct 15; 12(20):4516-9. Jones BD, La Clair JJ, Moore CE, Rheingold AL, Burkart MD. PMID: 20849075; PMCID: PMC2956428.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    54. Metabolic probes for imaging endosymbiotic bacteria within toxic dinoflagellates. Chem Commun (Camb). 2010 Nov 21; 46(43):8151-3. Reyes CP, La Clair JJ, Burkart MD. PMID: 20927429.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    55. An optimized immunoaffinity fluorescent method for natural product target elucidation. J Nat Prod. 2010 Oct 22; 73(10):1659-66. Yu WL, Guizzunti G, Foley TL, Burkart MD, La Clair JJ. PMID: 20836515.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    56. Synthetic studies on the mycolactone core. Org Biomol Chem. 2010 Nov 21; 8(22):5159-65. Ko KS, Alexander MD, Fontaine SD, Biggs-Houck JE, La Clair JJ, Burkart MD. PMID: 20844795.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    57. Conservation of progesterone hormone function in invertebrate reproduction. Proc Natl Acad Sci U S A. 2010 Jun 29; 107(26):11859-64. Stout EP, La Clair JJ, Snell TW, Shearer TL, Kubanek J. PMID: 20547846; PMCID: PMC2900687.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    58. Natural product mode of action (MOA) studies: a link between natural and synthetic worlds. Nat Prod Rep. 2010 Jul; 27(7):969-95. La Clair JJ. PMID: 20422068.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    59. Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chem Asian J. 2010 Feb 01; 5(2):342-51. Simon O, Reux B, La Clair JJ, Lear MJ. PMID: 20033979.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    60. Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B. J Org Chem. 2009 Dec 04; 74(23):9054-61. Kang M, Jones BD, Mandel AL, Hammons JC, DiPasquale AG, Rheingold AL, La Clair JJ, Burkart MD. PMID: 19883063.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    61. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov; 72(11):1980-7. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, La Clair JJ. PMID: 19842686.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    62. Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc. 2009 Sep 02; 131(34):12094-6. Hughes CC, Yang YL, Liu WT, Dorrestein PC, La Clair JJ, Fenical W. PMID: 19673475; PMCID: PMC2769490.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    63. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. PMID: 19578333; PMCID: PMC3510479.
      View in: PubMed   Mentions: 136     Fields:    Translation:Cells
    64. Grafta: a 3D environment for biomolecular networks. Int J Bioinform Res Appl. 2009; 5(5):564-9. Najmabadi P, Lee HH, Aung T, Thuya A, Ng J, La Clair JJ, Burkart MD. PMID: 19778870.
      View in: PubMed   Mentions:    Fields:    
    65. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32. Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ. PMID: 19097126; PMCID: PMC2820877.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    66. Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. J Am Chem Soc. 2008 Jun 11; 130(23):7256-8. Rodríguez AD, Lear MJ, La Clair JJ. PMID: 18479102.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    67. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS Chem Biol. 2008 May 16; 3(5):294-304. Baiga TJ, Guo H, Xing Y, O'Doherty GA, Dillin A, Austin MB, Noel JP, La Clair JJ. PMID: 18376812; PMCID: PMC2692194.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    68. Affinity analyses on moldable optical polycarbonate. Chembiochem. 2008 Jan 25; 9(2):201-5. Ko KS, Najmabadi P, La Clair JJ, Burkart MD. PMID: 18098256.
      View in: PubMed   Mentions: 1     Fields:    
    69. A synthetic entry to pladienolide B and FD-895. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5159-64. Mandel AL, Jones BD, La Clair JJ, Burkart MD. PMID: 17681759; PMCID: PMC2652656.
      View in: PubMed   Mentions: 11     Fields:    
    70. A systems perspective to digital structures in molecular analysis. Org Biomol Chem. 2007 Jan 21; 5(2):214-22. Najmabadi P, La Clair JJ, Burkart MD. PMID: 17205161.
      View in: PubMed   Mentions:    Fields:    
    71. Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb). 2006 Nov 28; (44):4602-4. Alexander MD, Fontaine SD, La Clair JJ, Dipasquale AG, Rheingold AL, Burkart MD. PMID: 17082856.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    72. Geometry in digital molecular arrays. Org Biomol Chem. 2006 Aug 21; 4(16):3052-5. La Clair JJ, Burkart MD. PMID: 16886071.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    73. Total syntheses of hexacyclinol, 5-epi-hexacyclinol, and desoxohexacyclinol unveil an antimalarial prodrug motif. Angew Chem Int Ed Engl. 2006 Apr 21; 45(17):2769-73. La Clair JJ. PMID: 16470558.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    74. Phorboxazole analogues induce association of cdk4 with extranuclear cytokeratin intermediate filaments. J Am Chem Soc. 2006 Mar 29; 128(12):3858-9. Forsyth CJ, Ying L, Chen J, La Clair JJ. PMID: 16551063.
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    75. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis EA, La Clair JJ. PMID: 16432909.
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    76. Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):901-4. Chen J, Ying L, Hansen TM, Engler MM, Lee CS, La Clair JJ, Forsyth CJ. PMID: 16300946.
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    77. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjug Chem. 2005 Nov-Dec; 16(6):1352-5. Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart MD. PMID: 16287229.
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    78. In vivo reporter labeling of proteins via metabolic delivery of coenzyme A analogues. J Am Chem Soc. 2005 Aug 17; 127(32):11234-5. Clarke KM, Mercer AC, La Clair JJ, Burkart MD. PMID: 16089439.
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    79. Fluorescent multiplex analysis of carrier protein post-translational modification. Chembiochem. 2005 Aug; 6(8):1335-7. Mercer AC, La Clair JJ, Burkart MD. PMID: 15997462.
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    80. Fluorescent profiling of natural product producers. J Am Chem Soc. 2005 Jul 06; 127(26):9320-1. Sandler JS, Fenical W, Gulledge BM, Chamberlin AR, La Clair JJ. PMID: 15984830.
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    81. A three-component photoreversible tag for thiols. J Org Chem. 2005 Apr 29; 70(9):3709-11. Clarke KM, La Clair JJ, Burkart MD. PMID: 15845011.
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    82. Modular synthesis of pantetheine and phosphopantetheine. Org Lett. 2004 Dec 23; 6(26):4801-3. Mandel AL, La Clair JJ, Burkart MD. PMID: 15606070.
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    83. A precipitator for the detection of thiophilic metals in aqua. J Am Chem Soc. 2004 Dec 22; 126(50):16582-6. Dickerson TJ, Reed NN, LaClair JJ, Janda KD. PMID: 15600364.
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    84. Manipulation of carrier proteins in antibiotic biosynthesis. Chem Biol. 2004 Feb; 11(2):195-201. La Clair JJ, Foley TL, Schegg TR, Regan CM, Burkart MD. PMID: 15123281.
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    85. Molecular screening on a compact disc. Org Biomol Chem. 2003 Sep 21; 1(18):3244-9. La Clair JJ, Burkart MD. PMID: 14527159.
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    86. Chemical defense in ascidians of the didemnidae family. Bioconjug Chem. 2003 Jan-Feb; 14(1):30-7. Joullié MM, Leonard MS, Portonovo P, Liang B, Ding X, La Clair JJ. PMID: 12526689.
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    87. Cyberpills. Chembiochem. 2001 Jun 01; 2(6):465-8. Pasquetto V, La Clair JJ. PMID: 11828479.
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    88. Fluorescent Fingerprinting of Molecular Recognition Landscapes J.J.L. thanks Wolfgang Rettig (Humboldt University) for his generosity during the preparation of this manuscript and the Uebbing Foundation for support. M.A. thanks Jan E. de Vries for continuous support and encouragement. Angew Chem Int Ed Engl. 2001 May 18; 40(10):1889-1892. Auer M, Graf C, La Clair JJ. PMID: 11385663.
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    89. Practical screening of mercury contamination in fish tissue. Bioorg Med Chem. 2001 Apr; 9(4):1067-71. Brümmer O, La Clair JJ, Janda KD. PMID: 11354663.
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    90. Screening hydrolysis over two-phases. J Biotechnol. 2000 Jan 07; 76(1):33-41. Cotenescu MG, La Clair JJ. PMID: 10784294.
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    91. An Atmospherically Driven Optical Switch. Angew Chem Int Ed Engl. 1999 Oct 18; 38(20):3045-3047. PMID: 10540416.
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    92. A rapid method to identify exo-protease inhibitors. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2291-6. Pryor KE, La Clair JJ. PMID: 10476856.
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    93. Synthesis of a New Class of Solvent-Sensitive Fluorescent Labels. Angew Chem Int Ed Engl. 1998 Feb 16; 37(3):325-329. La Clair JJ. PMID: 29711249.
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