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James La Clair

TitleProject Scientist
InstitutionUniversity of California San Diego
DepartmentChemistry and Biochemistry
Address9500 Gilman Drive #0358
La Jolla CA 92093
Phone858-534-1551
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gemperlein K, Zaburannyi N, Garcia R, La Clair JJ, Müller R. Metabolic and Biosynthetic Diversity in Marine Myxobacteria. Mar Drugs. 2018 Sep 05; 16(9). PMID: 30189599.
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    2. Garcia R, La Clair JJ, Müller R. Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics. Mar Drugs. 2018 Aug 29; 16(9). PMID: 30158489.
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    3. La Clair JJ. Correction: Encoding matter with regiospecific 12C/13C isotopic labels. Chem Commun (Camb). 2018 Apr 03; 54(28):3543. PMID: 29578218.
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    4. La Clair JJ. Encoding matter with regiospecific 12C/13C isotopic labels. Chem Commun (Camb). 2018 Mar 08; 54(21):2611-2614. PMID: 29417122.
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    5. Kornienko A, La Clair JJ. Covalent modification of biological targets with natural products through Paal-Knorr pyrrole formation. Nat Prod Rep. 2017 08 30; 34(9):1051-1060. PMID: 28808718.
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    6. León B, Kashyap MK, Chan WC, Krug KA, Castro JE, La Clair JJ, Burkart MD. A Challenging Pie to Splice: Drugging the Spliceosome. Angew Chem Int Ed Engl. 2017 Sep 25; 56(40):12052-12063. PMID: 28371109.
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    7. Dasari R, La Clair JJ, Kornienko A. Irreversible Protein Labeling by Paal-Knorr Conjugation. Chembiochem. 2017 09 19; 18(18):1792-1796. PMID: 28715110.
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    8. Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4142-E4148. PMID: 28484029.
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    9. Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. Structural basis for specific ligation of the peroxisome proliferator-activated receptor d. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2563-E2570. PMID: 28320959.
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    10. Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog. 2017 May; 56(5):1493-1500. PMID: 28019675.
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    11. Ambrose AJ, Santos EA, Jimenez PC, Rocha DD, Wilke DV, Beuzer P, Axelrod J, Kumar Kanduluru A, Fuchs PL, Cang H, Costa-Lotufo LV, Chapman E, La Clair JJ. Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem. 2017 03 16; 18(6):506-510. PMID: 28074539.
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    12. Crews LA, Balaian L, Delos Santos NP, Leu HS, Court AC, Lazzari E, Sadarangani A, Zipeto MA, La Clair JJ, Villa R, Kulidjian A, Storb R, Morris SR, Ball ED, Burkart MD, Jamieson CHM. RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML. Cell Stem Cell. 2016 11 03; 19(5):599-612. PMID: 27570067.
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    13. Beuzer P, Axelrod J, Trzoss L, Fenical W, Dasari R, Evidente A, Kornienko A, Cang H, La Clair JJ. Single dish gradient screening of small molecule localization. Org Biomol Chem. 2016 Sep 21; 14(35):8241-5. PMID: 27530345.
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    14. Kumar D, Kashyap MK, La Clair JJ, Villa R, Spaanderman I, Chien S, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. Selectivity in Small Molecule Splicing Modulation. ACS Chem Biol. 2016 10 21; 11(10):2716-2723. PMID: 27499047.
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    15. McCulloch IP, La Clair JJ, Jaremko MJ, Burkart MD. Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity. Chembiochem. 2016 09 02; 17(17):1598-601. PMID: 27271974.
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    16. Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart MD. An unusual intramolecular trans-amidation. Tetrahedron. 2016 Jun 23; 72(25):3605-3608. PMID: 27346894.
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    17. Beuzer P, La Clair JJ, Cang H. Color-Coded Super-Resolution Small-Molecule Imaging. Chembiochem. 2016 06 02; 17(11):999-1003. PMID: 26994590.
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    18. Dhar S, La Clair JJ, León B, Hammons JC, Yu Z, Kashyap MK, Castro JE, Burkart MD. A Carbohydrate-Derived Splice Modulator. J Am Chem Soc. 2016 Apr 20; 138(15):5063-8. PMID: 27058259.
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    19. Guo H, La Clair JJ, Masler EP, O'Doherty G, Xing Y. De Novo Asymmetric Synthesis and Biological Analysis of the Daumone Pheromones in Caenorhabditis elegans and in the Soybean Cyst Nematode Heterodera glycines. Tetrahedron. 2016 May 05; 72(18):2280-2286. PMID: 29445247.
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    20. Tallorin L, Finzel K, Nguyen QG, Beld J, La Clair JJ, Burkart MD. Trapping of the Enoyl-Acyl Carrier Protein Reductase-Acyl Carrier Protein Interaction. J Am Chem Soc. 2016 Mar 30; 138(12):3962-5. PMID: 26938266; PMCID: PMC4988885.
    21. Vickery CR, La Clair JJ, Burkart MD, Noel JP. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr Opin Chem Biol. 2016 Apr; 31:66-73. PMID: 26851514.
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    22. Álvarez-Micó X, Rocha DD, Guimarães LA, Ambrose A, Chapman E, Costa-Lotufo LV, La Clair JJ, Fenical W. The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway. Chembiochem. 2015 Sep 21; 16(14):2002-6. PMID: 26267855; PMCID: PMC4835225 [Available on 09/21/16].
    23. Rocha DD, Espejo VR, Rainier JD, La Clair JJ, Costa-Lotufo LV. Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging. Life Sci. 2015 Sep 01; 136:163-7. PMID: 26141988.
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    24. Santos EA, Quintela AL, Ferreira EG, Sousa TS, Pinto Fd, Hajdu E, Carvalho MS, Salani S, Rocha DD, Wilke DV, Torres Mda C, Jimenez PC, Silveira ER, La Clair JJ, Pessoa OD, Costa-Lotufo LV. Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus. J Nat Prod. 2015 May 22; 78(5):996-1004. PMID: 25879576.
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    25. Kashyap MK, Kumar D, Villa R, La Clair JJ, Benner C, Sasik R, Jones H, Ghia EM, Rassenti LZ, Kipps TJ, Burkart MD, Castro JE. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica. 2015 Jul; 100(7):945-54. PMID: 25862704; PMCID: PMC4486229.
    26. Chapman E, Maksim N, de la Cruz F, La Clair JJ. Correction: Chapman, E.; et al. Inhibitors of the AAA+ chaperone p97. Molecules 2015, 20, 3027-3049. Molecules. 2015 Mar 09; 20(3):4357-8. PMID: 25759952; PMCID: PMC4687487.
    27. Lau EC, Mason DJ, Eichhorst N, Engelder P, Mesa C, Kithsiri Wijeratne EM, Gunaherath GM, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatographic technique for natural product isolation. Org Biomol Chem. 2015 Feb 28; 13(8):2255-9. PMID: 25588099; PMCID: PMC4576851.
    28. Chapman E, Maksim N, de la Cruz F, La Clair JJ. Inhibitors of the AAA+ chaperone p97. Molecules. 2015 Feb 12; 20(2):3027-49. PMID: 25685910; PMCID: PMC4576884.
    29. Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, Burkart MD. Modeling linear and cyclic PKS intermediates through atom replacement. J Am Chem Soc. 2014 Dec 03; 136(48):16792-9. PMID: 25406716; PMCID: PMC4277753.
    30. Trzoss L, Fukuda T, Costa-Lotufo LV, Jimenez P, La Clair JJ, Fenical W. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14687-92. PMID: 25271322; PMCID: PMC4205641.
    31. Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem. 2014 Sep 22; 15(14):2125-31. PMID: 25125376; PMCID: PMC4187115.
    32. La Clair JJ, Loveridge ST, Tenney K, O'Neil-Johnson M, Chapman E, Crews P. In situ natural product discovery via an artificial marine sponge. PLoS One. 2014; 9(7):e100474. PMID: 25004127; PMCID: PMC4086721.
    33. Abreu PA, Sousa TS, Jimenez PC, Wilke DV, Rocha DD, Freitas HP, Pessoa OD, La Clair JJ, Costa-Lotufo LV. Identification of pyrroloformamide as a cytokinesis modulator. Chembiochem. 2014 Mar 03; 15(4):501-6. PMID: 24478218.
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    34. Farnaes L, La Clair JJ, Fenical W. Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94. Org Biomol Chem. 2014 Jan 21; 12(3):418-23. PMID: 24292715; PMCID: PMC3893886.
    35. Teasdale ME, Prudhomme J, Torres M, Braley M, Cervantes S, Bhatia SC, La Clair JJ, Le Roch K, Kubanek J. Pharmacokinetics, metabolism, and in vivo efficacy of the antimalarial natural product bromophycolide A. ACS Med Chem Lett. 2013 Oct 10; 4(10):989-993. PMID: 24159368.
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    36. Villa R, Kashyap MK, Kumar D, Kipps TJ, Castro JE, La Clair JJ, Burkart MD. Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J Med Chem. 2013 Sep 12; 56(17):6576-82. PMID: 23919277; PMCID: PMC3809018.
    37. Yu WL, Jones BD, Kang M, Hammons JC, La Clair JJ, Burkart MD. Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF). J Nat Prod. 2013 May 24; 76(5):817-23. PMID: 23659282; PMCID: PMC3706094.
    38. Lipson JM, Thomsen M, Moore BS, Clausen RP, La Clair JJ, Burkart MD. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. Chembiochem. 2013 May 27; 14(8):950-3. PMID: 23650044; PMCID: PMC3749784.
    39. Guo Y, Zheng Z, La Clair JJ, Chory J, Noel JP. Smoke-derived karrikin perception by the a/ß-hydrolase KAI2 from Arabidopsis. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8284-9. PMID: 23613584; PMCID: PMC3657771.
    40. Rothmann M, Kang M, Villa R, Ntai I, La Clair JJ, Kelleher NL, Chapman E, Burkart MD. Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of coenzyme A. J Am Chem Soc. 2013 Apr 24; 135(16):5962-5. PMID: 23550886; PMCID: PMC3657554.
    41. Almeida JG, Maia AI, Wilke DV, Silveira ER, Braz-Filho R, La Clair JJ, Costa-Lotufo LV, Pessoa OD. Palyosulfonoceramides A and B: unique sulfonylated ceramides from the Brazilian zoanthids Palythoa caribaeorum and Protopalythoa variabilis. Mar Drugs. 2012 Dec 14; 10(12):2846-60. PMID: 23242205; PMCID: PMC3528130.
    42. Villa R, Mandel AL, Jones BD, La Clair JJ, Burkart MD. Structure of FD-895 revealed through total synthesis. Org Lett. 2012 Nov 02; 14(21):5396-9. PMID: 23072504; PMCID: PMC3518397.
    43. La Clair JJ, Rheingold AL, Burkart MD. Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae. J Nat Prod. 2011 Oct 28; 74(10):2045-51. PMID: 21939217.
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    44. Kumar KA, La Clair JJ, Fuchs PL. Synthesis and evaluation of a fluorescent ritterazine-cephalostatin hybrid. Org Lett. 2011 Oct 07; 13(19):5334-7. PMID: 21913733; PMCID: PMC3264888.
    45. Sharma SV, Jothivasan VK, Newton GL, Upton H, Wakabayashi JI, Kane MG, Roberts AA, Rawat M, La Clair JJ, Hamilton CJ. Chemical and Chemoenzymatic syntheses of bacillithiol: a unique low-molecular-weight thiol amongst low G + C Gram-positive bacteria. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7101-4. PMID: 21751306.
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    46. Vera B, Rodríguez AD, La Clair JJ. Aplysqualenol A binds to the light chain of dynein type 1 (DYNLL1). Angew Chem Int Ed Engl. 2011 Aug 22; 50(35):8134-8. PMID: 21744448; PMCID: PMC3582901.
    47. Stout EP, Cervantes S, Prudhomme J, France S, La Clair JJ, Le Roch K, Kubanek J. Bromophycolide A targets heme crystallization in the human malaria parasite Plasmodium falciparum. ChemMedChem. 2011 Sep 05; 6(9):1572-7. PMID: 21732541; PMCID: PMC3381860.
    48. La Clair JJ, Rodríguez AD. Isolation of the ß-galactosphingolipid coniferoside using a tumor cell proteome reverse affinity protocol. Bioorg Med Chem. 2011 Nov 15; 19(22):6645-53. PMID: 21784648.
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    49. Newton GL, Buchmeier N, La Clair JJ, Fahey RC. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. PMID: 21665483; PMCID: PMC3123436.
    50. Jones BD, La Clair JJ, Moore CE, Rheingold AL, Burkart MD. Convergent route to the spirohexenolide macrocycle. Org Lett. 2010 Oct 15; 12(20):4516-9. PMID: 20849075; PMCID: PMC2956428.
    51. Reyes CP, La Clair JJ, Burkart MD. Metabolic probes for imaging endosymbiotic bacteria within toxic dinoflagellates. Chem Commun (Camb). 2010 Nov 21; 46(43):8151-3. PMID: 20927429.
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    52. Yu WL, Guizzunti G, Foley TL, Burkart MD, La Clair JJ. An optimized immunoaffinity fluorescent method for natural product target elucidation. J Nat Prod. 2010 Oct 22; 73(10):1659-66. PMID: 20836515.
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    53. Ko KS, Alexander MD, Fontaine SD, Biggs-Houck JE, La Clair JJ, Burkart MD. Synthetic studies on the mycolactone core. Org Biomol Chem. 2010 Nov 21; 8(22):5159-65. PMID: 20844795.
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    54. Stout EP, La Clair JJ, Snell TW, Shearer TL, Kubanek J. Conservation of progesterone hormone function in invertebrate reproduction. Proc Natl Acad Sci U S A. 2010 Jun 29; 107(26):11859-64. PMID: 20547846; PMCID: PMC2900687.
    55. La Clair JJ. Natural product mode of action (MOA) studies: a link between natural and synthetic worlds. Nat Prod Rep. 2010 Jul; 27(7):969-95. PMID: 20422068.
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    56. Simon O, Reux B, La Clair JJ, Lear MJ. Total synthesis confirms laetirobin as a formal Diels-Alder adduct. Chem Asian J. 2010 Feb 01; 5(2):342-51. PMID: 20033979.
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    57. Kang M, Jones BD, Mandel AL, Hammons JC, DiPasquale AG, Rheingold AL, La Clair JJ, Burkart MD. Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B. J Org Chem. 2009 Dec 04; 74(23):9054-61. PMID: 19883063.
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    58. Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J Nat Prod. 2009 Nov; 72(11):1980-7. PMID: 19842686.
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    59. Hughes CC, Yang YL, Liu WT, Dorrestein PC, La Clair JJ, Fenical W. Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc. 2009 Sep 02; 131(34):12094-6. PMID: 19673475; PMCID: PMC2769490.
    60. Newton GL, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. PMID: 19578333; PMCID: PMC3510479.
    61. Najmabadi P, Lee HH, Aung T, Thuya A, Ng J, La Clair JJ, Burkart MD. Grafta: a 3D environment for biomolecular networks. Int J Bioinform Res Appl. 2009; 5(5):564-9. PMID: 19778870.
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    62. Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32. PMID: 19097126; PMCID: PMC2820877.
    63. Rodríguez AD, Lear MJ, La Clair JJ. Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol. J Am Chem Soc. 2008 Jun 11; 130(23):7256-8. PMID: 18479102.
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    64. Baiga TJ, Guo H, Xing Y, O'Doherty GA, Dillin A, Austin MB, Noel JP, La Clair JJ. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS Chem Biol. 2008 May 16; 3(5):294-304. PMID: 18376812; PMCID: PMC2692194.
    65. Ko KS, Najmabadi P, La Clair JJ, Burkart MD. Affinity analyses on moldable optical polycarbonate. Chembiochem. 2008 Jan 25; 9(2):201-5. PMID: 18098256.
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    66. Mandel AL, Jones BD, La Clair JJ, Burkart MD. A synthetic entry to pladienolide B and FD-895. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5159-64. PMID: 17681759; PMCID: PMC2652656.
    67. Najmabadi P, La Clair JJ, Burkart MD. A systems perspective to digital structures in molecular analysis. Org Biomol Chem. 2007 Jan 21; 5(2):214-22. PMID: 17205161.
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    68. Alexander MD, Fontaine SD, La Clair JJ, Dipasquale AG, Rheingold AL, Burkart MD. Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb). 2006 Nov 28; (44):4602-4. PMID: 17082856.
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    69. La Clair JJ, Burkart MD. Geometry in digital molecular arrays. Org Biomol Chem. 2006 Aug 21; 4(16):3052-5. PMID: 16886071.
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    70. La Clair JJ. Total syntheses of hexacyclinol, 5-epi-hexacyclinol, and desoxohexacyclinol unveil an antimalarial prodrug motif. Angew Chem Int Ed Engl. 2006 Apr 21; 45(17):2769-73. PMID: 16470558.
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    71. Forsyth CJ, Ying L, Chen J, La Clair JJ. Phorboxazole analogues induce association of cdk4 with extranuclear cytokeratin intermediate filaments. J Am Chem Soc. 2006 Mar 29; 128(12):3858-9. PMID: 16551063.
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    72. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis EA, La Clair JJ. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. PMID: 16432909.
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    73. Chen J, Ying L, Hansen TM, Engler MM, Lee CS, La Clair JJ, Forsyth CJ. Design and total synthesis of a fluorescent phorboxazole A analog for cellular studies. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):901-4. PMID: 16300946.
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    74. Shute TS, Matsushita M, Dickerson TJ, La Clair JJ, Janda KD, Burkart MD. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjug Chem. 2005 Nov-Dec; 16(6):1352-5. PMID: 16287229.
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    75. Clarke KM, Mercer AC, La Clair JJ, Burkart MD. In vivo reporter labeling of proteins via metabolic delivery of coenzyme A analogues. J Am Chem Soc. 2005 Aug 17; 127(32):11234-5. PMID: 16089439.
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    76. Mercer AC, La Clair JJ, Burkart MD. Fluorescent multiplex analysis of carrier protein post-translational modification. Chembiochem. 2005 Aug; 6(8):1335-7. PMID: 15997462.
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    77. Sandler JS, Fenical W, Gulledge BM, Chamberlin AR, La Clair JJ. Fluorescent profiling of natural product producers. J Am Chem Soc. 2005 Jul 06; 127(26):9320-1. PMID: 15984830.
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    78. Clarke KM, La Clair JJ, Burkart MD. A three-component photoreversible tag for thiols. J Org Chem. 2005 Apr 29; 70(9):3709-11. PMID: 15845011.
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    79. Mandel AL, La Clair JJ, Burkart MD. Modular synthesis of pantetheine and phosphopantetheine. Org Lett. 2004 Dec 23; 6(26):4801-3. PMID: 15606070.
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    80. La Clair JJ, Foley TL, Schegg TR, Regan CM, Burkart MD. Manipulation of carrier proteins in antibiotic biosynthesis. Chem Biol. 2004 Feb; 11(2):195-201. PMID: 15123281.
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    81. La Clair JJ, Burkart MD. Molecular screening on a compact disc. Org Biomol Chem. 2003 Sep 21; 1(18):3244-9. PMID: 14527159.
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    82. Joullié MM, Leonard MS, Portonovo P, Liang B, Ding X, La Clair JJ. Chemical defense in ascidians of the didemnidae family. Bioconjug Chem. 2003 Jan-Feb; 14(1):30-7. PMID: 12526689.
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    83. Pasquetto V, La Clair JJ. Cyberpills. Chembiochem. 2001 Jun 01; 2(6):465-8. PMID: 11828479.
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    84. Auer M, Graf C, La Clair JJ. Fluorescent Fingerprinting of Molecular Recognition Landscapes J.J.L. thanks Wolfgang Rettig (Humboldt University) for his generosity during the preparation of this manuscript and the Uebbing Foundation for support. M.A. thanks Jan E. de Vries for continuous support and encouragement. Angew Chem Int Ed Engl. 2001 May 18; 40(10):1889-1892. PMID: 11385663.
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    85. Brümmer O, La Clair JJ, Janda KD. Practical screening of mercury contamination in fish tissue. Bioorg Med Chem. 2001 Apr; 9(4):1067-71. PMID: 11354663.
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    86. Cotenescu MG, La Clair JJ. Screening hydrolysis over two-phases. J Biotechnol. 2000 Jan 07; 76(1):33-41. PMID: 10784294.
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    87. Pryor KE, La Clair JJ. A rapid method to identify exo-protease inhibitors. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2291-6. PMID: 10476856.
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    88. La Clair JJ. Synthesis of a New Class of Solvent-Sensitive Fluorescent Labels. Angew Chem Int Ed Engl. 1998 Feb 16; 37(3):325-329. PMID: 29711249.
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