Ronald Evans

Title(s)Adjunct Professor, Cell and Developmental Biology
SchoolVc-academic Affairs
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse research activities and funding
    Engineering human islet-like organoids for transplantation
    NIH R01DK120480Sep 30, 2018 - Jul 31, 2022
    Role: Principal Investigator
    A Hub for the Nuclear Receptor Signaling Atlas1
    NIH U24DK097748Sep 17, 2012 - Aug 31, 2019
    Role: Principal Investigator
    Role of Immune Mechanisms in Athersclerosis and Inflammation
    NIH P01HL088093Apr 1, 2007 - Apr 30, 2020
    Role: Co-Investigator
    PPARs: Transcriptional Regulators of Metabolism
    NIH R13DK063898Jan 1, 2003 - Dec 31, 2003
    Role: Principal Investigator
    Nuclear Receptors and Coregulators in Health and Disease
    NIH U19DK062434Aug 15, 2002 - Jul 31, 2012
    Role: Co-Investigator
    DETECTION AND MODELS OF TOXICANT EXPOSURE
    NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
    Role: Co-Investigator
    NUCLEAR RECEPTORS 2000
    NIH R13DK057518Mar 20, 2000 - Feb 28, 2001
    Role: Principal Investigator
    SCOR in Molecular Medicine and Atherosclerosis
    NIH P50HL056989Apr 23, 1997 - Mar 31, 2008
    Role: Co-Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator
    Translational Cardiovascular Science and Medicine
    NIH T32HL007770Jul 1, 1993 - Dec 31, 2009
    Role: Principal Investigator
    Transcriptional Regulation of Cell Growth
    NIH P01CA054418Jun 1, 1991 - Apr 30, 2006
    Role: Co-Investigator
    Spatial Regulation of Developmental Gene Expression
    NIH R01HL105278Sep 12, 1990 - Sep 30, 2020
    Role: Principal Investigator
    Spatial Regulation of Developmental Gene Expression
    NIH R01HD027183Sep 12, 1990 - May 31, 2010
    Role: Principal Investigator
    GORDON RESEARCH CONFERENCE ON MOLECULAR GENETICS
    NIH R13HD027968Jul 20, 1990 - Jul 19, 1991
    Role: Principal Investigator
    A Laser Microbeam Biotechnology Resource
    NIH P41RR001192Dec 1, 1979 - Mar 31, 2013
    Role: Co-Investigator
    Hormonal Regulation of Mammalian Gene Expression
    NIH R01DK057978Apr 1, 1979 - Mar 31, 2025
    Role: Principal Investigator
    Hormonal Regulation of Mammalian Gene Expression
    NIH R37DK057978Apr 1, 1979 - Sep 30, 2020
    Role: Principal Investigator
    HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSION
    NIH R37GM026444Apr 1, 1979 - Mar 31, 2000
    Role: Principal Investigator
    HORMONAL REGULATION OF MAMMALIAN GENE EXPRESSION
    NIH R01GM026444Apr 1, 1979 - Mar 31, 1990
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA014195Dec 1, 1977 - Jan 31, 2024
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions. Proc Natl Acad Sci U S A. 2025 May 20; 122(20):e2426179122. Fan W, Oh TG, Wang HJ, Crossley L, He M, Robbins H, Koopari C, Dai Y, Truitt ML, Liddle C, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 40354528.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Sympathetic activation of white adipose tissue recruits neutrophils to limit energy expenditure. Res Sq. 2025 Apr 16. Son S, Xu C, Jang J, Dinh M, Skorobogatko Y, Fu H, Valentine JM, An G, Ying W, Yu RT, Downes M, Evans RM, Saltiel AR. PMID: 40321773; PMCID: PMC12047989.
      View in: PubMed   Mentions:
    3. BCL6 coordinates muscle mass homeostasis with nutritional states. Proc Natl Acad Sci U S A. 2025 Jan 28; 122(4):e2408896122. Wang HJ, Fan W, Liu S, Kim K, Matsushima A, Ogawa S, Kang HG, Zhu J, Estepa G, He M, Crossley L, Liddle C, Kim MS, Truitt ML, Yu RT, Atkins AR, Downes M, Evans RM. PMID: 39841144; PMCID: PMC11789089.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice. JCI Insight. 2024 Nov 08; 9(21). Pessentheiner AR, Spann NJ, Autran CA, Oh TG, Grunddal KV, Coker JK, Painter CD, Ramms B, Chiang AW, Wang CY, Hsiao J, Wang Y, Quach A, Booshehri LM, Hammond A, Tognaccini C, Latasiewicz J, Willemsen L, Zengler K, de Winther MP, Hoffman HM, Philpott M, Cribbs AP, Oppermann U, Lewis NE, Witztum JL, Yu R, Atkins AR, Downes M, Evans RM, Glass CK, Bode L, Gordts PL. PMID: 39325548; PMCID: PMC11601559.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming. Proc Natl Acad Sci U S A. 2024 Oct 15; 121(42):e2411321121. Yang Y, Zhang X, Cai D, Zheng X, Zhao X, Zou JX, Zhang J, Borowsky AD, Dall'Era MA, Corey E, Mitsiades N, Kung HJ, Chen X, Li JJ, Downes M, Evans RM, Chen HW. PMID: 39383000; PMCID: PMC11494309.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Vitamin D Receptor Regulates Liver Regeneration After Partial Hepatectomy in Male Mice. Endocrinology. 2024 Jul 01; 165(8). Elangovan H, Stokes RA, Keane J, Chahal S, Samer C, Agoncillo M, Yu J, Chen J, Downes M, Evans RM, Liddle C, Gunton JE. PMID: 38963813; PMCID: PMC11250209.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Targeting nuclear receptor corepressors for reversible male contraception. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2320129121. Hong SH, Castro G, Wang D, Nofsinger R, Kane M, Folias A, Atkins AR, Yu RT, Napoli JL, Sassone-Corsi P, de Rooij DG, Liddle C, Downes M, Evans RM. PMID: 38377195; PMCID: PMC10907271.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Feb; 6(2):273-289. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. PMID: 38286821; PMCID: PMC10896723.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    9. A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proc Natl Acad Sci U S A. 2024 Jan 09; 121(2):e2316104121. Abe Y, Kofman ER, Ouyang Z, Cruz-Becerra G, Spann NJ, Seidman JS, Troutman TD, Stender JD, Taylor H, Fan W, Link VM, Shen Z, Sakai J, Downes M, Evans RM, Kadonaga JT, Rosenfeld MG, Glass CK. PMID: 38165941; PMCID: PMC10786282.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. Inhibiting stromal Class I HDACs curbs pancreatic cancer progression. Nat Commun. 2023 Dec 06; 14(1):7791. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 38057326; PMCID: PMC10700526.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. Circulation. 2024 01 16; 149(3):227-250. Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker JK, Jensen BC, Pei L, Burris T, Zhang L. PMID: 37961903; PMCID: PMC10842599.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression. Mol Cell. 2023 10 05; 83(19):3421-3437.e11. Abe Y, Kofman ER, Almeida M, Ouyang Z, Ponte F, Mueller JR, Cruz-Becerra G, Sakai M, Prohaska TA, Spann NJ, Resende-Coelho A, Seidman JS, Stender JD, Taylor H, Fan W, Link VM, Cobo I, Schlachetzki JCM, Hamakubo T, Jepsen K, Sakai J, Downes M, Evans RM, Yeo GW, Kadonaga JT, Manolagas SC, Rosenfeld MG, Glass CK. PMID: 37751740; PMCID: PMC10591845.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    13. Inhibiting Stromal Class I HDACs Curbs Pancreatic Cancer Progression. bioRxiv. 2023 Sep 14. Liang G, Oh TG, Hah N, Tiriac H, Shi Y, Truitt ML, Antal CE, Atkins AR, Li Y, Fraser C, Ng S, Pinto AFM, Nelson DC, Estepa G, Bashi S, Banayo E, Dai Y, Liddle C, Yu RT, Hunter T, Engle DD, Han H, Von Hoff DD, Downes M, Evans RM. PMID: 37745372; PMCID: PMC10515810.
      View in: PubMed   Mentions:
    14. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Rep. 2023 08 29; 42(8):112997. Fu T, Huan T, Rahman G, Zhi H, Xu Z, Oh TG, Guo J, Coulter S, Tripathi A, Martino C, McCarville JL, Zhu Q, Cayabyab F, Low B, He M, Xing S, Vargas F, Yu RT, Atkins A, Liddle C, Ayres J, Raffatellu M, Dorrestein PC, Downes M, Knight R, Evans RM. PMID: 37611587; PMCID: PMC10903535.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    16. Silver electroceutical technology to treat sarcopenia. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2300036120. Kim MY, Shin HY, Cho SC, Yang S, Intisar A, Woo HJ, Choi YS, You CL, Kang JS, Lee YI, Park SC, Yea K, Oh TG, Downes M, Evans RM, Kim MS. PMID: 37549292; PMCID: PMC10438839.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Zinc accumulation in Atriplex lentiformis is driven by plant genes and the soil microbiome. Sci Total Environ. 2023 Nov 15; 899:165667. Kushwaha P, Tran A, Quintero D, Song M, Yu Q, Yu R, Downes M, Evans RM, Babst-Kostecka A, Schroeder JI, Maier RM. PMID: 37478925; PMCID: PMC10529914.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    18. PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2217826120. Yoon BK, Kim H, Oh TG, Oh SK, Jo S, Kim M, Chun KH, Hwang N, Lee S, Jin S, Atkins AR, Yu RT, Downes M, Kim JW, Kim H, Evans RM, Cheong JH, Fang S. PMID: 37192160; PMCID: PMC10214193.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    19. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 04 21; 18(4):756-771. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. PMID: 36988910; PMCID: PMC11584170.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    20. Legacy: a tribute to Terri Grodzicker of Genes & Development. Genes Dev. 2023 Jan 01; 37(1-2):20-21. Evans RM. PMID: 37061954; PMCID: PMC10046438.
      View in: PubMed   Mentions:    Fields:    
    21. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A. 2022 12 20; 119(51):e2213041119. Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt M, Medina P, He M, Yu RT, Atkins A, Zheng Y, Liddle C, Downes M, Evans RM. PMID: 36508655; PMCID: PMC9907109.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Timed use of cardiac glycoside protects the heart. Nat Cardiovasc Res. 2022 Nov; 1(11):973-975. Wang HJ, Evans RM. PMID: 39195909.
      View in: PubMed   Mentions:
    23. Autocrine FGF1 signaling promotes glucose uptake in adipocytes. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2122382119. Nies VJM, Struik D, Liu S, Liu W, Kruit JK, Downes M, van Zutphen T, Verkade HJ, Evans RM, Jonker JW. PMID: 36161959; PMCID: PMC9546606.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    24. Gut metagenome-derived signature predicts hepatic decompensation and mortality in NAFLD-related cirrhosis. Aliment Pharmacol Ther. 2022 11; 56(10):1475-1485. Sharpton SR, Oh TG, Madamba E, Wang C, Yu RT, Atkins AR, Huan T, Downes M, Evans RM, Loomba R. PMID: 36164267; PMCID: PMC9746351.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 10 04; 34(10):1548-1560.e6. Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M. PMID: 36041455; PMCID: PMC9547947.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    26. Shared Mechanisms between Cardiovascular Disease and NAFLD. Semin Liver Dis. 2022 11; 42(4):455-464. Huang DQ, Downes M, Evans RM, Witztum JL, Glass CK, Loomba R. PMID: 36008083; PMCID: PMC9828940.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    27. Metabolic Messengers: fibroblast growth factor 1. Nat Metab. 2022 06; 4(6):663-671. Gasser E, Sancar G, Downes M, Evans RM. PMID: 35681108; PMCID: PMC9624216.
      View in: PubMed   Mentions: 9     Fields:    
    28. Daily running enhances molecular and physiological circadian rhythms in skeletal muscle. Mol Metab. 2022 07; 61:101504. Casanova-Vallve N, Duglan D, Vaughan ME, Pariollaud M, Handzlik MK, Fan W, Yu RT, Liddle C, Downes M, Delezie J, Mello R, Chan AB, Westermark PO, Metallo CM, Evans RM, Lamia KA. PMID: 35470095; PMCID: PMC9079800.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Obesity alters pathology and treatment response in inflammatory disease. Nature. 2022 04; 604(7905):337-342. Bapat SP, Whitty C, Mowery CT, Liang Y, Yoo A, Jiang Z, Peters MC, Zhang LJ, Vogel I, Zhou C, Nguyen VQ, Li Z, Chang C, Zhu WS, Hastie AT, He H, Ren X, Qiu W, Gayer SG, Liu C, Choi EJ, Fassett M, Cohen JN, Sturgill JL, Crotty Alexander LE, Suh JM, Liddle C, Atkins AR, Yu RT, Downes M, Liu S, Nikolajczyk BS, Lee IK, Guttman-Yassky E, Ansel KM, Woodruff PG, Fahy JV, Sheppard D, Gallo RL, Ye CJ, Evans RM, Zheng Y, Marson A. PMID: 35355021; PMCID: PMC9165753.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    30. Interorgan crosstalk in pancreatic islet function and pathology. FEBS Lett. 2022 03; 596(5):607-619. Evans RM, Wei Z. PMID: 35014695; PMCID: PMC8930530.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022 01 18; 132(2). Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. PMID: 34847077; PMCID: PMC8759781.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    32. BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ahmed NS, Gatchalian J, Ho J, Burns MJ, Hah N, Wei Z, Downes M, Evans RM, Hargreaves DC. PMID: 34983841; PMCID: PMC8740701.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. FGF1 and insulin control lipolysis by convergent pathways. Cell Metab. 2022 01 04; 34(1):171-183.e6. Sancar G, Liu S, Gasser E, Alvarez JG, Moutos C, Kim K, van Zutphen T, Wang Y, Huddy TF, Ross B, Dai Y, Zepeda D, Collins B, Tilley E, Kolar MJ, Yu RT, Atkins AR, van Dijk TH, Saghatelian A, Jonker JW, Downes M, Evans RM. PMID: 34986332; PMCID: PMC8863067.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    34. Colon cancer checks in when bile acids check out: the bile acid-nuclear receptor axis in colon cancer. Essays Biochem. 2021 12 17; 65(6):1015-1024. Tang Q, Evans RM. PMID: 34414429; PMCID: PMC8628182.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
      View in: PubMed   Mentions: 2     Fields:    
    36. Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 2021 11; 599(7884):296-301. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. PMID: 34707293; PMCID: PMC9186421.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    37. Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. J Biol Chem. 2021 11; 297(5):101173. Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Suyama K, Nose T, Yoshihara E, Downes M, Evans RM, Matsushima A. PMID: 34499926; PMCID: PMC8551653.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    38. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A. 2021 08 31; 118(35). Wang L, Oh TG, Magida J, Estepa G, Obayomi SMB, Chong LW, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. PMID: 34446564; PMCID: PMC8536317.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    39. FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021 06 29; 35(13):109331. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. PMID: 34192547; PMCID: PMC8293281.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    40. Neural basis of opioid-induced respiratory depression and its rescue. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S. PMID: 34074761; PMCID: PMC8201770.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 07 13; 54(7):1561-1577.e7. Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100; PMCID: PMC9273026.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    42. Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis. Cell Metab. 2021 03 02; 33(3):457. Oh TG, Kim SM, Atkins AR, Yu RT, Downes M, Evans RM, Loomba R. PMID: 33657386.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 12(1):293-320. Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. PMID: 33631374; PMCID: PMC8166943.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    44. Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 2021 Feb; 590(7844):E27. Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. PMID: 33469222; PMCID: PMC11332361.
      View in: PubMed   Mentions:    Fields:    
    45. Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts. Oncogenesis. 2020 Nov 09; 9(11):100. Noel P, Hussein S, Ng S, Antal CE, Lin W, Rodela E, Delgado P, Naveed S, Downes M, Lin Y, Evans RM, Von Hoff DD, Han H. PMID: 33168807; PMCID: PMC7653036.
      View in: PubMed   Mentions: 31  
    46. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Cell Metab. 2020 Nov 03; 32(5):901. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. PMID: 33147487; PMCID: PMC7891106.
      View in: PubMed   Mentions: 30     Fields:    
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    234. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem. 2006 May 26; 281(21):15013-20. Zhou J, Zhai Y, Mu Y, Gong H, Uppal H, Toma D, Ren S, Evans RM, Xie W. PMID: 16556603; PMCID: PMC4109972.
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    235. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006 Mar; 116(3):590-7. Barish GD, Narkar VA, Evans RM. PMID: 16511591; PMCID: PMC1386117.
      View in: PubMed   Mentions: 215     Fields:    Translation:HumansAnimals
    236. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3902-7. Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. PMID: 16505366; PMCID: PMC1450163.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    237. PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3444-9. Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. PMID: 16492734; PMCID: PMC1413918.
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    238. Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2434-9. Lee CH, Kang K, Mehl IR, Nofsinger R, Alaynick WA, Chong LW, Rosenfeld JM, Evans RM. PMID: 16467150; PMCID: PMC1413732.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    239. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 2006 Feb; 3(2):111-22. Wang Z, Qi C, Krones A, Woodring P, Zhu X, Reddy JK, Evans RM, Rosenfeld MG, Hunter T. PMID: 16459312.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    240. Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia. Cancer Cell. 2006 Feb; 9(2):81-94. Sternsdorf T, Phan VT, Maunakea ML, Ocampo CB, Sohal J, Silletto A, Galimi F, Le Beau MM, Evans RM, Kogan SC. PMID: 16473276.
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    241. Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. Toxicol Appl Pharmacol. 2005 Dec 01; 209(2):174-82. Noreault TL, Jacobs JM, Nichols RC, Trask HW, Wrighton SA, Sinclair PR, Evans RM, Sinclair JF. PMID: 15907335.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    242. Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005 Oct; 25(19):8456-64. Zhao X, Sternsdorf T, Bolger TA, Evans RM, Yao TP. PMID: 16166628; PMCID: PMC1265742.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    243. Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. Drug Metab Dispos. 2005 Dec; 33(12):1827-36. Wolf KK, Wood SG, Hunt JA, Walton-Strong BW, Yasuda K, Lan L, Duan SX, Hao Q, Wrighton SA, Jeffery EH, Evans RM, Szakacs JG, von Moltke LL, Greenblatt DJ, Court MH, Schuetz EG, Sinclair PR, Sinclair JF. PMID: 16141365.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    244. The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. Mol Endocrinol. 2005 Oct; 19(10):2433-6. Margolis RN, Evans RM, O'Malley BW, NURSA Atlas Consortium. PMID: 16051673.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    245. A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol Endocrinol. 2005 Oct; 19(10):2437-50. Fu M, Sun T, Bookout AL, Downes M, Yu RT, Evans RM, Mangelsdorf DJ. PMID: 16051663.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    246. A Nuclear Receptor Atlas: macrophage activation. Mol Endocrinol. 2005 Oct; 19(10):2466-77. Barish GD, Downes M, Alaynick WA, Yu RT, Ocampo CB, Bookout AL, Mangelsdorf DJ, Evans RM. PMID: 16051664.
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    247. The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol. 2005 Jun; 19(6):1429-38. Evans RM. PMID: 15914712.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    248. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2063-8. Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, Downes M. PMID: 15684063; PMCID: PMC548592.
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    249. Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2198-203. Sonoda J, Chong LW, Downes M, Barish GD, Coulter S, Liddle C, Lee CH, Evans RM. PMID: 15671183; PMCID: PMC548561.
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    250. Development of ecdysone-regulated lentiviral vectors. Mol Ther. 2005 Jan; 11(1):142-8. Galimi F, Saez E, Gall J, Hoong N, Cho G, Evans RM, Verma IM. PMID: 15585415.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    251. Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts. Mol Cell Biol. 2004 Dec; 24(24):10661-9. Shalom-Barak T, Nicholas JM, Wang Y, Zhang X, Ong ES, Young TH, Gendler SJ, Evans RM, Barak Y. PMID: 15572671; PMCID: PMC533980.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    252. A nuclear strike against Listeria--the evolving life of LXR. Cell. 2004 Oct 15; 119(2):149-51. Barish GD, Evans RM. PMID: 15479632.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    253. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004 Nov; 10(11):1245-50. Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako FA, Xiao Y, Chen YE, Yang Q. PMID: 15475963.
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    254. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem. 2004 Nov 19; 279(47):49517-22. Zhang J, Huang W, Qatanani M, Evans RM, Moore DD. PMID: 15358766.
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    255. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004 Oct; 2(10):e294. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. PMID: 15328533; PMCID: PMC509410.
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    256. 2003 Keio Medical Science Prize commemorative lecture. PPARs and the complex journey to obesity. Keio J Med. 2004 Jun; 53(2):53-8. Evans RM. PMID: 15264367.
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    257. PPARs and LXRs: atherosclerosis goes nuclear. Trends Endocrinol Metab. 2004 May-Jun; 15(4):158-65. Barish GD, Evans RM. PMID: 15109614.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    258. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Nat Med. 2004 May; 10(5):530-4. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M. PMID: 15107844.
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    259. PPARs and the complex journey to obesity. Nat Med. 2004 Apr; 10(4):355-61. Evans RM, Barish GD, Wang YX. PMID: 15057233.
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    260. Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4047-52. Tsai CC, Kao HY, Mitzutani A, Banayo E, Rajan H, McKeown M, Evans RM. PMID: 15016912; PMCID: PMC384693.
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    261. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21; 279(21):22250-7. Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD. PMID: 15004017.
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    262. PPAR gamma signaling exacerbates mammary gland tumor development. Genes Dev. 2004 Mar 01; 18(5):528-40. Saez E, Rosenfeld J, Livolsi A, Olson P, Lombardo E, Nelson M, Banayo E, Cardiff RD, Izpisua-Belmonte JC, Evans RM. PMID: 15037548; PMCID: PMC374235.
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    263. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol. 2004 Feb; 65(2):292-300. Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, Ren S, Moore DD, Evans RM, Xie W. PMID: 14742670.
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    264. A methylation-mediator complex in hormone signaling. Genes Dev. 2004 Jan 15; 18(2):144-56. Xu W, Cho H, Kadam S, Banayo EM, Anderson S, Yates JR, Emerson BM, Evans RM. PMID: 14729568; PMCID: PMC324421.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    265. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
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    266. Packing, specificity, and mutability at the binding interface between the p160 coactivator and CREB-binding protein. Protein Sci. 2004 Jan; 13(1):203-10. Demarest SJ, Deechongkit S, Dyson HJ, Evans RM, Wright PE. PMID: 14691235; PMCID: PMC2286511.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    267. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15712-7. He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM. PMID: 14660788; PMCID: PMC307633.
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    268. Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J Immunol. 2003 Dec 01; 171(11):5743-50. Natarajan C, Muthian G, Barak Y, Evans RM, Bright JJ. PMID: 14634082.
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    269. Muscle-specific Pparg deletion causes insulin resistance. Nat Med. 2003 Dec; 9(12):1491-7. Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J. PMID: 14625542.
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    270. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003 Oct 17; 302(5644):453-7. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. PMID: 12970571.
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    271. Genetic deficiency in Pparg does not alter development of experimental prostate cancer. Nat Med. 2003 Oct; 9(10):1265-6. Saez E, Olson P, Evans RM. PMID: 12960963.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    272. Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors. Endocrinology. 2003 Jun; 144(6):2201-7. Lee CH, Olson P, Evans RM. PMID: 12746275.
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    273. Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell. 2003 Apr 18; 113(2):159-70. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. PMID: 12705865.
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    274. Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. J Mol Biol. 2003 Apr 04; 327(4):819-32. Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE. PMID: 12654265.
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    275. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr; 11(4):1079-92. Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. PMID: 12718892; PMCID: PMC6179153.
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    276. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol Endocrinol. 2003 Jul; 17(7):1268-82. Rosenfeld JM, Vargas R, Xie W, Evans RM. PMID: 12663745.
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    277. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org Biomol Chem. 2003 Mar 21; 1(6):908-20. Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. PMID: 12929628.
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    278. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4150-5. Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM. PMID: 12644700; PMCID: PMC153063.
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    279. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003 Mar; 130(6):1113-22. Stenman J, Yu RT, Evans RM, Campbell K. PMID: 12571103.
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    280. Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding. Am J Physiol Endocrinol Metab. 2003 Mar; 284(3):E618-26. Miles PD, Barak Y, Evans RM, Olefsky JM. PMID: 12556354.
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    281. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1268-73. Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PMID: 12540828; PMCID: PMC298762.
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    282. Acetylation and methylation in nuclear receptor gene activation. Methods Enzymol. 2003; 364:205-23. Xu W, Cho H, Evans RM. PMID: 14631847.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    283. Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain. J Biol Chem. 2003 Feb 28; 278(9):7366-73. Kao HY, Han CC, Komar AA, Evans RM. PMID: 12468549.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    284. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13801-6. Sonoda J, Xie W, Rosenfeld JM, Barwick JL, Guzelian PS, Evans RM. PMID: 12370413; PMCID: PMC129778.
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    285. Peroxisome proliferator-activated receptor-gamma in macrophage lipid homeostasis. Trends Endocrinol Metab. 2002 Oct; 13(8):331-5. Lee CH, Evans RM. PMID: 12217489.
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    286. Vitamin D receptor as an intestinal bile acid sensor. Science. 2002 May 17; 296(5571):1313-6. Makishima M, Lu TT, Xie W, Whitfield GK, Domoto H, Evans RM, Haussler MR, Mangelsdorf DJ. PMID: 12016314.
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    287. DSF nuclear receptor acts as a repressor in culture and in vivo. Dev Biol. 2002 May 15; 245(2):315-28. Pitman JL, Tsai CC, Edeen PT, Finley KD, Evans RM, McKeown M. PMID: 11977984.
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    288. Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Drug Discov Today. 2002 May 01; 7(9):509-15. Xie W, Evans RM. PMID: 11983567.
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    289. The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2613-8. Shi Y, Hon M, Evans RM. PMID: 11867749; PMCID: PMC122396.
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    290. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell. 2002 Feb; 9(2):265-77. Tini M, Benecke A, Um SJ, Torchia J, Evans RM, Chambon P. PMID: 11864601.
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    291. Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature. 2002 Jan 31; 415(6871):549-53. Demarest SJ, Martinez-Yamout M, Chung J, Chen H, Xu W, Dyson HJ, Evans RM, Wright PE. PMID: 11823864.
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    292. Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):303-8. Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. PMID: 11756685; PMCID: PMC117556.
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    293. Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J Biol Chem. 2002 Jan 04; 277(1):187-93. Kao HY, Lee CH, Komarov A, Han CC, Evans RM. PMID: 11677242.
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