Anthony Molina

Title(s)Associate Professor, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of Illinois, ChicagoPhDNeuroscience
    Harvard Medical SchoolPost Doc
    Boston University School of MedicinePost Doc

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures
    NIH U01AG060897Sep 30, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's Disease
    NIH R01AG061805Sep 30, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Circulating factors mediating systemic bioenergetic capacity in the pathogenesis and treatment of Alzheimer's Disease
    NIH R56AG057864Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Blood Base Bioenergetic Profiling: A Novel Approach for Identifying Alzheimer's Disease Risk and Pathology
    NIH R01AG054523Jul 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Bioenergetics and Rehabilitation in Older Patients with Acute Heart Failure
    NIH R21AG051077May 1, 2016 - Mar 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blood-based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease. Alzheimers Dement. 2022 Jul 23. Mahapatra G, Gao Z, Bateman JR, Lockhart SN, Bergstrom J, DeWitt AR, Piloso JE, Kramer PA, Gonzalez-Armenta JL, Amick KA, Casanova R, Craft S, Molina AJA. PMID: 35870133.
      View in: PubMed   Mentions: 2     Fields:    
    2. The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA). Geroscience. 2022 Jun 23. Ding J, Lohman K, Molina A, Delbono O, Bertoni A, Shea S, Post W, Guo X, Barr RG, Manichaikul AW, Pankow JS, Rotter JI, Hoeschele I, Kritchevsky SB, Liu Y. PMID: 35737188.
      View in: PubMed   Mentions: 1     Fields:    
    3. Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis. FASEB J. 2022 02; 36(2):e22146. Junker A, Wang J, Gouspillou G, Ehinger JK, Elmér E, Sjövall F, Fisher-Wellman KH, Neufer PD, Molina AJA, Ferrucci L, Picard M. PMID: 35073429.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Brain region-specific disruption of mitochondrial bioenergetics in cynomolgus macaques fed a Western versus a Mediterranean diet. Am J Physiol Endocrinol Metab. 2021 11 01; 321(5):E652-E664. Amick KA, Mahapatra G, Bergstrom J, Gao Z, Craft S, Register TC, Shively CA, Molina AJA. PMID: 34569271; PMCID: PMC8791787.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    5. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 09 14; 78(11):1166-1187. Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. PMID: 34503685; PMCID: PMC8525886.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    6. The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 10; 43(5):2139-2148. Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. PMID: 34370163; PMCID: PMC8599742.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Sato-Kaneko F, Yao S, Lao FS, Nan J, Shpigelman J, Cheng A, Saito T, Messer K, Pu M, Shukla NM, Cottam HB, Chan M, Molina AJ, Corr M, Hayashi T, Carson DA. PMID: 34078669; PMCID: PMC8201894.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    8. Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice. J Gerontol A Biol Sci Med Sci. 2021 02 25; 76(3):434-439. Gonzalez-Armenta JL, Li N, Lee RL, Lu B, Molina AJA. PMID: 33377482; PMCID: PMC8177798.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. An Acidic Environment Induces APOL1-Associated Mitochondrial Fragmentation. Am J Nephrol. 2020; 51(9):695-704. Li D, Snipes JA, Murea M, Molina AJA, Divers J, Freedman BI, Ma L, Petrovic S. PMID: 32866949; PMCID: PMC7511450.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. PMID: 32428862; PMCID: PMC7232099.
      View in: PubMed   Mentions: 4  
    11. APOL1 Kidney-Risk Variants Induce Mitochondrial Fission. Kidney Int Rep. 2020 Jun; 5(6):891-904. Ma L, Ainsworth HC, Snipes JA, Murea M, Choi YA, Langefeld CD, Parks JS, Bharadwaj MS, Chou JW, Hemal AK, Petrovic S, Craddock AL, Cheng D, Hawkins GA, Miller LD, Hicks PJ, Saleem MA, Divers J, Molina AJA, Freedman BI. PMID: 32518871; PMCID: PMC7271005.
      View in: PubMed   Mentions: 15  
    12. Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet. J Nutr. 2019 09 01; 149(9):1493-1502. Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA. PMID: 31112997; PMCID: PMC6736071.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019 07 16; 28(3):759-772.e10. Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. PMID: 31315053; PMCID: PMC6713209.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    14. Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias. Mol Genet Metab. 2019 11; 128(3):228-235. Dixon N, Li T, Marion B, Faust D, Dozier S, Molina A, Rudnick S, Bonkovsky HL. PMID: 31153822; PMCID: PMC6864263.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight. 2019 03 21; 4(6). Douros JD, Niu J, Sdao S, Gregg T, Fisher-Wellman K, Bharadwaj M, Molina A, Arumugam R, Martin M, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell J, D'Alessio D. PMID: 30777938; PMCID: PMC6483064.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond). 2018 12 12; 132(23):2509-2518. Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA. PMID: 30401689; PMCID: PMC6512318.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep. 2018 04 27; 8(1):6635. Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM. PMID: 29703899; PMCID: PMC5923234.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    18. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017; 2017:7317251. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. PMID: 29098063; PMCID: PMC5643153.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    19. Blood-based bioenergetic profiling: A readout of systemic bioenergetic capacity that is related to differences in body composition. Redox Biol. 2017 10; 13:418-420. Molina AJA. PMID: 28688322; PMCID: PMC5499103.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys. Obesity (Silver Spring). 2017 04; 25(4):689-696. Kavanagh K, Davis AT, Peters DE, LeGrand AC, Bharadwaj MS, Molina AJ. PMID: 28236433; PMCID: PMC5373959.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction. J Am Soc Nephrol. 2017 Apr; 28(4):1093-1105. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI. PMID: 27821631; PMCID: PMC5373457.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    22. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol. 2016 12; 10:65-77. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. PMID: 27693859; PMCID: PMC5045569.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    23. Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC Heart Fail. 2016 08; 4(8):636-45. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW. PMID: 27179829; PMCID: PMC4967040.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    24. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015; 2:40. Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. PMID: 26448868; PMCID: PMC4594906.
      View in: PubMed   Mentions: 16  
    25. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015 Oct; 70:84-91. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. PMID: 26226578; PMCID: PMC6471587.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    26. Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Radiat Res. 2015 Mar; 183(3):291-304. Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM. PMID: 25738895; PMCID: PMC4465128.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    27. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. J Vis Exp. 2015 Feb 07; (96). Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. PMID: 25741892; PMCID: PMC4354623.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015 Jan 02; 290(1):396-408. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. PMID: 25404738; PMCID: PMC4281742.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    29. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biol. 2014; 2:1008-15. Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B. PMID: 25460737; PMCID: PMC4215389.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    30. Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1394-9. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. PMID: 25030980; PMCID: PMC4731403.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCellsCTClinical Trials
    31. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013 Jul 03; 5(192):192ra85. Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. PMID: 23825301; PMCID: PMC3760005.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    32. A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. J Vis Exp. 2012 Jul 20; (65):e3991. Lovy A, Molina AJ, Cerqueira FM, Trudeau K, Shirihai OS. PMID: 22847388; PMCID: PMC3476419.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    33. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. PMID: 22292091; PMCID: PMC3266928.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 Nov 07; 52(12):8657-64. Trudeau K, Molina AJ, Roy S. PMID: 21979999; PMCID: PMC3230288.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    35. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol. 2010 Jul; 177(1):447-55. Trudeau K, Molina AJ, Guo W, Roy S. PMID: 20522647; PMCID: PMC2893686.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    36. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87. Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajn?czky G, Shirihai OS. PMID: 20445168; PMCID: PMC2928626.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    37. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. PMID: 19581419; PMCID: PMC2750232.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansAnimalsCells
    38. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304. Molina AJ, Shirihai OS. PMID: 19426874; PMCID: PMC5967387.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. PMID: 18223655; PMCID: PMC3918232.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    40. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. PMID: 18200046; PMCID: PMC2234339.
      View in: PubMed   Mentions: 1356     Fields:    Translation:AnimalsCells
    41. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. PMID: 17686943.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    42. Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate. J Gen Physiol. 2007 Aug; 130(2):169-82. Kreitzer MA, Collis LP, Molina AJ, Smith PJ, Malchow RP. PMID: 17664345; PMCID: PMC2151636.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    43. Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate. J Physiol. 2004 Nov 01; 560(Pt 3):639-57. Molina AJ, Verzi MP, Birnbaum AD, Yamoah EN, Hammar K, Smith PJ, Malchow RP. PMID: 15272044; PMCID: PMC1665295.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. Intracellular release of caged calcium in skate horizontal cells using fine optical fibers. Biol Bull. 2003 Oct; 205(2):215-6. Molina AJ, Hammar K, Sanger R, Smith PJ, Malchow RP. PMID: 14583536.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    Anthony's Networks
    Concepts (244)
    Derived automatically from this person's publications.
    Co-Authors (12)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department