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Anthony Molina

Title(s)Associate Professor In Residence, Medicine
SchoolHealth Sciences
Phone858-246-5930
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    Collapse Research 
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    Aging Biomarkers: Integrating Omic Profiles with Mechanistic Measures
    NIH/NIA U01AG060897Sep 30, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's Disease
    NIH/NIA R01AG061805Sep 30, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Circulating factors mediating systemic bioenergetic capacity in the pathogenesis and treatment of Alzheimer's Disease
    NIH/NIA R56AG057864Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Blood Base Bioenergetic Profiling: A Novel Approach for Identifying Alzheimer's Disease Risk and Pathology
    NIH/NIA R01AG054523Jul 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Bioenergetics and Rehabilitation in Older Patients with Acute Heart Failure
    NIH/NIA R21AG051077May 1, 2016 - Mar 31, 2018
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA. Skeletal Muscle Mitochondrial Respiration Is Elevated in Female Cynomolgus Macaques Fed a Western Compared with a Mediterranean Diet. J Nutr. 2019 Sep 01; 149(9):1493-1502. PMID: 31112997.
      View in: PubMed
    2. Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Mitochondrial GTP Links Nutrient Sensing to ß Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019 Jul 16; 28(3):759-772.e10. PMID: 31315053.
      View in: PubMed
    3. Dixon N, Li T, Marion B, Faust D, Dozier S, Molina A, Rudnick S, Bonkovsky HL. Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias. Mol Genet Metab. 2019 May 20. PMID: 31153822.
      View in: PubMed
    4. Douros JD, Niu J, Sdao S, Gregg T, Fisher-Wellman K, Bharadwaj M, Molina A, Arumugam R, Martin M, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell J, D'Alessio D. Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight. 2019 Mar 21; 4(6). PMID: 30777938.
      View in: PubMed
    5. Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA. Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond). 2018 12 12; 132(23):2509-2518. PMID: 30401689.
      View in: PubMed
    6. Holmila RJ, Vance SA, Chen X, Wu H, Shukla K, Bharadwaj MS, Mims J, Wary Z, Marrs G, Singh R, Molina AJ, Poole LB, King SB, Furdui CM. Mitochondria-targeted Probes for Imaging Protein Sulfenylation. Sci Rep. 2018 04 27; 8(1):6635. PMID: 29703899.
      View in: PubMed
    7. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017; 2017:7317251. PMID: 29098063.
      View in: PubMed
    8. Molina AJA. Blood-based bioenergetic profiling: A readout of systemic bioenergetic capacity that is related to differences in body composition. Redox Biol. 2017 10; 13:418-420. PMID: 28688322.
      View in: PubMed
    9. Kavanagh K, Davis AT, Peters DE, LeGrand AC, Bharadwaj MS, Molina AJ. Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys. Obesity (Silver Spring). 2017 04; 25(4):689-696. PMID: 28236433.
      View in: PubMed
    10. Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI. APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction. J Am Soc Nephrol. 2017 Apr; 28(4):1093-1105. PMID: 27821631.
      View in: PubMed
    11. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol. 2016 12; 10:65-77. PMID: 27693859.
      View in: PubMed
    12. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW. Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC Heart Fail. 2016 08; 4(8):636-45. PMID: 27179829.
      View in: PubMed
    13. Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015; 2:40. PMID: 26448868.
      View in: PubMed
    14. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ. Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol. 2015 Oct; 70:84-91. PMID: 26226578.
      View in: PubMed
    15. Mims J, Bansal N, Bharadwaj MS, Chen X, Molina AJ, Tsang AW, Furdui CM. Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer. Radiat Res. 2015 Mar; 183(3):291-304. PMID: 25738895.
      View in: PubMed
    16. Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. J Vis Exp. 2015 Feb 07; (96). PMID: 25741892.
      View in: PubMed
    17. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015 Jan 02; 290(1):396-408. PMID: 25404738.
      View in: PubMed
    18. Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biol. 2014; 2:1008-15. PMID: 25460737.
      View in: PubMed
    19. Tyrrell DJ, Bharadwaj MS, Van Horn CG, Kritchevsky SB, Nicklas BJ, Molina AJ. Respirometric Profiling of Muscle Mitochondria and Blood Cells Are Associated With Differences in Gait Speed Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2015 Nov; 70(11):1394-9. PMID: 25030980.
      View in: PubMed
    20. Kalghatgi S, Spina CS, Costello JC, Liesa M, Morones-Ramirez JR, Slomovic S, Molina A, Shirihai OS, Collins JJ. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013 Jul 03; 5(192):192ra85. PMID: 23825301.
      View in: PubMed
    21. Lovy A, Molina AJ, Cerqueira FM, Trudeau K, Shirihai OS. A faster, high resolution, mtPA-GFP-based mitochondrial fusion assay acquiring kinetic data of multiple cells in parallel using confocal microscopy. J Vis Exp. 2012 Jul 20; (65):e3991. PMID: 22847388.
      View in: PubMed
    22. Gall JM, Wang Z, Liesa M, Molina A, Havasi A, Schwartz JH, Shirihai O, Borkan SC, Bonegio RG. Role of mitofusin 2 in the renal stress response. PLoS One. 2012; 7(1):e31074. PMID: 22292091.
      View in: PubMed
    23. Trudeau K, Molina AJ, Roy S. High glucose induces mitochondrial morphology and metabolic changes in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 Nov 07; 52(12):8657-64. PMID: 21979999.
      View in: PubMed
    24. Trudeau K, Molina AJ, Guo W, Roy S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am J Pathol. 2010 Jul; 177(1):447-55. PMID: 20522647.
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    25. Twig G, Liu X, Liesa M, Wikstrom JD, Molina AJ, Las G, Yaniv G, Hajnóczky G, Shirihai OS. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C477-87. PMID: 20445168.
      View in: PubMed
    26. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15. PMID: 19581419.
      View in: PubMed
    27. Molina AJ, Shirihai OS. Monitoring mitochondrial dynamics with photoactivatable [corrected] green fluorescent protein. Methods Enzymol. 2009; 457:289-304. PMID: 19426874.
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    28. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
      View in: PubMed
    29. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46. PMID: 18200046.
      View in: PubMed
    30. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78. PMID: 17686943.
      View in: PubMed
    31. Kreitzer MA, Collis LP, Molina AJ, Smith PJ, Malchow RP. Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate. J Gen Physiol. 2007 Aug; 130(2):169-82. PMID: 17664345.
      View in: PubMed
    32. Molina AJ, Verzi MP, Birnbaum AD, Yamoah EN, Hammar K, Smith PJ, Malchow RP. Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate. J Physiol. 2004 Nov 01; 560(Pt 3):639-57. PMID: 15272044.
      View in: PubMed
    33. Molina AJ, Hammar K, Sanger R, Smith PJ, Malchow RP. Intracellular release of caged calcium in skate horizontal cells using fine optical fibers. Biol Bull. 2003 Oct; 205(2):215-6. PMID: 14583536.
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