Monica Guma

Title(s)Professor In Residence, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Biography 
    Collapse Education and Training
    UC San Diegopostdoctoral fellowship and rheumatology clinical fellowship
    Pompeu Fabra University, Barcelona, SpainPhDImmunology
    Germans Trias i Pujol Hospital, Barcelona, SpainRheumatology Fellowship
    Autonomous University, Barcelona, SpainMD

    Collapse Overview 
    Collapse Overview
    Research Interest
    - Signal Transduction pathways and rheumatoid arthritis(RA) pathogenesis
    - Synoviocytes biology in rheumatoid arthritis (RA)

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting hexokinase-2 in rheumatoid arthritis
    NIH R01AR073324Aug 15, 2018 - May 31, 2023
    Role: Principal Investigator
    Choline metabolites as biomarkers in rheumatoid arthritis
    NIH R03AR068094Mar 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    Choline kinase: a novel target for rheumatoid arthritis
    NIH K08AR064834Sep 1, 2013 - Aug 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular imaging for evaluation of synovitis associated with osteoarthritis: a narrative review. Arthritis Res Ther. 2024 Jan 16; 26(1):25. Lee K, Niku S, Koo SJ, Belezzuoli E, Guma M. PMID: 38229205; PMCID: PMC10790518.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Epidemiology and outcomes of emergency department visits in systemic lupus erythematosus: Insights from the nationwide emergency department sample (NEDS). Lupus. 2023 Dec; 32(14):1646-1655. Dhital R, Pokharel A, Karageorgiou I, Poudel DR, Guma M, Kalunian K. PMID: 37961765; PMCID: PMC10666498.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. High contrast cartilaginous endplate imaging in spine using three dimensional dual-inversion recovery prepared ultrashort echo time (3D DIR-UTE) sequence. Skeletal Radiol. 2023 Nov 08. Athertya JS, Lo J, Chen X, Shin SH, Malhi BS, Jerban S, Ji Y, Sedaghat S, Yoshioka H, Du J, Guma M, Chang EY, Ma Y. PMID: 37935923.
      View in: PubMed   Mentions:    Fields:    
    4. Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation. Nat Biotechnol. 2023 Nov; 41(11):1656. Gauglitz JM, West KA, Bittremieux W, Williams CL, Weldon KC, Panitchpakdi M, Di Ottavio F, Aceves CM, Brown E, Sikora NC, Jarmusch AK, Martino C, Tripathi A, Meehan MJ, Dorrestein K, Shaffer JP, Coras R, Vargas F, Goldasich LD, Schwartz T, Bryant M, Humphrey G, Johnson AJ, Spengler K, Belda-Ferre P, Diaz E, McDonald D, Zhu Q, Elijah EO, Wang M, Marotz C, Sprecher KE, Vargas-Robles D, Withrow D, Ackermann G, Herrera L, Bradford BJ, Marques LMM, Amaral JG, Silva RM, Veras FP, Cunha TM, Oliveira RDR, Louzada-Junior P, Mills RH, Piotrowski PK, Servetas SL, Da Silva SM, Jones CM, Lin NJ, Lippa KA, Jackson SA, Daouk RK, Galasko D, Dulai PS, Kalashnikova TI, Wittenberg C, Terkeltaub R, Doty MM, Kim JH, Rhee KE, Beauchamp-Walters J, Wright KP, Dominguez-Bello MG, Manary M, Oliveira MF, Boland BS, Lopes NP, Guma M, Swafford AD, Dutton RJ, Knight R, Dorrestein PC. PMID: 37853256.
      View in: PubMed   Mentions: 3     Fields:    
    5. Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis. Arthritis Res Ther. 2023 09 20; 25(1):176. Ahmed S, Mahony CB, Torres A, Murillo-Saich J, Kemble S, Cedeno M, John P, Bhatti A, Croft AP, Guma M. PMID: 37730663; PMCID: PMC10510293.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes. Front Immunol. 2023; 14:1103231. Torres A, Kang S, Mahony CB, Cedeño M, Oliveira PG, Fernandez-Bustamante M, Kemble S, Laragione T, Gulko PS, Croft AP, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 37529037; PMCID: PMC10389265.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Serum metabolomic profiling identifies potential biomarkers in arthritis in older adults: an exploratory study. Metabolomics. 2023 04 06; 19(4):37. Cedeno M, Murillo-Saich J, Coras R, Cedola F, Brandy A, Prior A, Pedersen A, Mateo L, Martinez-Morillo M, Guma M. PMID: 37022535.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Infection-related hospitalisation in young adults with systemic lupus erythematosus: data from the National Inpatient Sample. Lupus Sci Med. 2023 04; 10(1). Dhital R, Guma M, Poudel DR, Chambers C, Kalunian K. PMID: 37019477; PMCID: PMC10083864.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Prevalence, characteristics, and health burden of rheumatoid arthritis in the U.S. veteran population. J Psychiatr Res. 2023 03; 159:224-229. Morse JL, Afari N, Norman SB, Guma M, Pietrzak RH. PMID: 36746059.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Psoriatic disease and non-alcoholic fatty liver disease shared pathogenesis review. Semin Arthritis Rheum. 2023 04; 59:152165. Torosian K, Lal E, Kavanaugh A, Loomba R, Ajmera V, Guma M. PMID: 36716599; PMCID: PMC9992353.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid Arthritis. Molecules. 2023 Jan 11; 28(2). Lindqvist HM, Winkvist A, Gjertsson I, Calder PC, Armando AM, Quehenberger O, Coras R, Guma M. PMID: 36677774.
      View in: PubMed   Mentions: 1     Fields:    
    12. Ultrashort echo time magnetic resonance imaging of the osteochondral junction. NMR Biomed. 2023 02; 36(2):e4843. Lombardi AF, Guma M, Chung CB, Chang EY, Du J, Ma YJ. PMID: 36264245; PMCID: PMC9845195.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes. Front Immunol. 2022; 13:984408. Torres A, Pedersen B, Guma M. PMID: 36341411; PMCID: PMC9632162.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    14. Serum Phospholipid Profile Changes in Gaucher Disease and Parkinson's Disease. Int J Mol Sci. 2022 Sep 08; 23(18). López de Frutos L, Almeida F, Murillo-Saich J, Conceição VA, Guma M, Queheberger O, Giraldo P, Miltenberger-Miltenyi G. PMID: 36142296; PMCID: PMC9499334.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Docking and Molecular Dynamics Study to Identify Novel Phytobiologics from Dracaena trifasciata against Metabolic Reprogramming in Rheumatoid Arthritis. Life (Basel). 2022 Jul 29; 12(8). Ahmed S, John P, Paracha RZ, Bhatti A, Guma M. PMID: 36013327; PMCID: PMC9410489.
      View in: PubMed   Mentions: 1  
    16. Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes. Arthritis Res Ther. 2022 07 25; 24(1):175. Guma M, Dadpey B, Coras R, Mikuls TR, Hamilton B, Quehenberger O, Thorisdottir H, Bittleman D, Lauro K, Reilly SM, Liu-Bryan R, Terkeltaub R. PMID: 35879786; PMCID: PMC9310412.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Editorial: The role of immunometabolism in autoimmune mediated and autoinflammatory disorders. Front Immunol. 2022; 13:969939. Pucino V, Guma M. PMID: 35911700; PMCID: PMC9336634.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis. Osteoarthr Cartil Open. 2022 Sep; 4(3):100295. Murillo-Saich JD, Coras R, Meyer R, Llorente C, Lane NE, Guma M. PMID: 36474936; PMCID: PMC9718344.
      View in: PubMed   Mentions:
    19. Enhancing untargeted metabolomics using metadata-based source annotation. Nat Biotechnol. 2022 12; 40(12):1774-1779. Gauglitz JM, West KA, Bittremieux W, Williams CL, Weldon KC, Panitchpakdi M, Di Ottavio F, Aceves CM, Brown E, Sikora NC, Jarmusch AK, Martino C, Tripathi A, Meehan MJ, Dorrestein K, Shaffer JP, Coras R, Vargas F, Goldasich LD, Schwartz T, Bryant M, Humphrey G, Johnson AJ, Spengler K, Belda-Ferre P, Diaz E, McDonald D, Zhu Q, Elijah EO, Wang M, Marotz C, Sprecher KE, Vargas-Robles D, Withrow D, Ackermann G, Herrera L, Bradford BJ, Marques LMM, Amaral JG, Silva RM, Veras FP, Cunha TM, Oliveira RDR, Louzada-Junior P, Mills RH, Piotrowski PK, Servetas SL, Da Silva SM, Jones CM, Lin NJ, Lippa KA, Jackson SA, Daouk RK, Galasko D, Dulai PS, Kalashnikova TI, Wittenberg C, Terkeltaub R, Doty MM, Kim JH, Rhee KE, Beauchamp-Walters J, Wright KP, Dominguez-Bello MG, Manary M, Oliveira MF, Boland BS, Lopes NP, Guma M, Swafford AD, Dutton RJ, Knight R, Dorrestein PC. PMID: 35798960; PMCID: PMC10277029.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    20. Baseline microbiome and metabolome are associated with response to ITIS diet in an exploratory trial in patients with rheumatoid arthritis. Clin Transl Med. 2022 07; 12(7):e959. Coras R, Martino C, Gauglitz JM, Cedola F, Tripathi A, Jarmusch AK, Alharthi M, Fernandez-Bustamante M, Agustin-Perez M, Singh A, Choi SI, Rivera T, Nguyen K, Shekhtman T, Holt T, Lee S, Golshan S, Dorrestein PC, Knight R, Guma M. PMID: 35802808; PMCID: PMC9269999.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Effusion-synovitis worsening mediates the association between body mass index and Kellgren-Lawrence progression in obese individuals: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2022 09; 30(9):1278-1286. Bañuls-Mirete M, Lombardi AF, Posis AIB, Shadyab AH, Chang EY, Lane NE, Guma M. PMID: 35714760; PMCID: PMC9910445.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2022 07; 74(7):1159-1171. Torres A, Pedersen B, Cobo I, Ai R, Coras R, Murillo-Saich J, Nygaard G, Sanchez-Lopez E, Murphy A, Wang W, Firestein GS, Guma M. PMID: 35128827; PMCID: PMC9246826.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    23. Lipidomic Profiling in Synovial Tissue. Front Med (Lausanne). 2022; 9:857135. Coras R, Murillo-Saich JD, Singh AG, Kavanaugh A, Guma M. PMID: 35492314; PMCID: PMC9051397.
      View in: PubMed   Mentions: 1  
    24. Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response. Cell Rep. 2022 03 08; 38(10):110489. Cobo I, Cheng A, Murillo-Saich J, Coras R, Torres A, Abe Y, Lana AJ, Schlachetzki J, Liu-Bryan R, Terkeltaub R, Sanchez-Lopez E, Glass CK, Guma M. PMID: 35263587; PMCID: PMC8989403.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022 05; 18(5):258-275. Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M. PMID: 35165404; PMCID: PMC9050956.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    26. Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types. Cell Mol Life Sci. 2021 Dec; 78(23):7693-7707. Umar S, Palasiewicz K, Volin MV, Romay B, Rahat R, Tetali C, Arami S, Guma M, Ascoli C, Sweiss N, Zomorrodi RK, O'Neill LAJ, Shahrara S. PMID: 34705053; PMCID: PMC8739866.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    27. Metabolomics profiling predicts outcome of tocilizumab in rheumatoid arthritis: an exploratory study. Metabolomics. 2021 08 16; 17(9):74. Murillo-Saich JD, Diaz-Torne C, Ortiz MA, Coras R, Gil-Alabarse P, Pedersen A, Corominas H, Vidal S, Guma M. PMID: 34402961; PMCID: PMC8810395.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Differences in oxylipin profile in psoriasis versus psoriatic arthritis. Arthritis Res Ther. 2021 07 24; 23(1):200. Coras R, Kavanaugh A, Kluzniak A, Holt D, Weilgosz A, Aaron A, Quehenberger O, Ritchlin C, Guma M. PMID: 34303373; PMCID: PMC8310583.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Ultrashort echo time adiabatic T1ρ (UTE-Adiab-T1ρ) is sensitive to human cadaveric knee joint deformation induced by mechanical loading and unloading. Magn Reson Imaging. 2021 07; 80:98-105. Jerban S, Ma Y, Kasibhatla A, Wu M, Szeverenyi N, Guma M, Covey D, D'lima D, Ward SR, Sah RL, Chang EY, Du J, Chung CB. PMID: 33945858.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Imbalance Between Omega-6- and Omega-3-Derived Bioactive Lipids in Arthritis in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 02 25; 76(3):415-425. Coras R, Pedersen B, Narasimhan R, Brandy A, Mateo L, Prior-Español A, Kavanaugh A, Armando AM, Jain M, Quehenberger O, Martínez-Morillo M, Guma M. PMID: 32361743; PMCID: PMC7907486.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Association of myostatin, a cytokine released by muscle, with inflammation in rheumatoid arthritis: A cross-sectional study. Medicine (Baltimore). 2021 Jan 22; 100(3):e24186. Murillo-Saich JD, Vazquez-Villegas ML, Ramirez-Villafaña M, Saldaña-Cruz AM, Aceves-Aceves JA, Gonzalez-Lopez L, Guma M, Gamez-Nava JI. PMID: 33546034; PMCID: PMC7837870.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Auto-deconvolution and molecular networking of gas chromatography-mass spectrometry data. Nat Biotechnol. 2021 02; 39(2):169-173. Aksenov AA, Laponogov I, Zhang Z, Doran SLF, Belluomo I, Veselkov D, Bittremieux W, Nothias LF, Nothias-Esposito M, Maloney KN, Misra BB, Melnik AV, Smirnov A, Du X, Jones KL, Jones KL, Dorrestein K, Panitchpakdi M, Ernst M, van der Hooft JJJ, Gonzalez M, Carazzone C, Amézquita A, Callewaert C, Morton JT, Quinn RA, Bouslimani A, Orio AA, Petras D, Smania AM, Couvillion SP, Burnet MC, Nicora CD, Zink E, Metz TO, Artaev V, Humston-Fulmer E, Gregor R, Meijler MM, Mizrahi I, Eyal S, Anderson B, Dutton R, Lugan R, Boulch PL, Guitton Y, Prevost S, Poirier A, Dervilly G, Le Bizec B, Fait A, Persi NS, Song C, Gashu K, Coras R, Guma M, Manasson J, Scher JU, Barupal DK, Alseekh S, Fernie AR, Mirnezami R, Vasiliou V, Schmid R, Borisov RS, Kulikova LN, Knight R, Wang M, Hanna GB, Dorrestein PC, Veselkov K. PMID: 33169034; PMCID: PMC7971188.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    33. Micronutrients: Essential Treatment for Inflammatory Arthritis? Curr Rheumatol Rep. 2020 10 26; 22(12):87. Bañuls-Mirete M, Ogdie A, Guma M. PMID: 33104882; PMCID: PMC8078476.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. Cells. 2020 03 30; 9(4). Coras R, Murillo-Saich JD, Guma M. PMID: 32235564; PMCID: PMC7226773.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    35. Interleukin-17 Inhibition in Spondyloarthritis Is Associated With Subclinical Gut Microbiome Perturbations and a Distinctive Interleukin-25-Driven Intestinal Inflammation. Arthritis Rheumatol. 2020 04; 72(4):645-657. Manasson J, Wallach DS, Guggino G, Stapylton M, Badri MH, Solomon G, Reddy SM, Coras R, Aksenov AA, Jones DR, Girija PV, Neimann AL, Heguy A, Segal LN, Dorrestein PC, Bonneau R, Guma M, Ciccia F, Ubeda C, Clemente JC, Scher JU. PMID: 31729183; PMCID: PMC7113119.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    36. Host engulfment pathway controls inflammation in inflammatory bowel disease. FEBS J. 2020 09; 287(18):3967-3988. Sayed IM, Suarez K, Lim E, Singh S, Pereira M, Ibeawuchi SR, Katkar G, Dunkel Y, Mittal Y, Chattopadhyay R, Guma M, Boland BS, Dulai PS, Sandborn WJ, Ghosh P, Das S. PMID: 32003126; PMCID: PMC7390677.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    37. Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis. Contemp Clin Trials Commun. 2020 Mar; 17:100524. Bustamante MF, Agustín-Perez M, Cedola F, Coras R, Narasimhan R, Golshan S, Guma M. PMID: 32025586; PMCID: PMC6997513.
      View in: PubMed   Mentions: 16  
    38. RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation. Cell Mol Gastroenterol Hepatol. 2020; 9(2):295-312. Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. PMID: 31606566; PMCID: PMC6957844.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    39. Fibroblast-Like Synoviocytes Glucose Metabolism as a Therapeutic Target in Rheumatoid Arthritis. Front Immunol. 2019; 10:1743. de Oliveira PG, Farinon M, Sanchez-Lopez E, Miyamoto S, Guma M. PMID: 31428089; PMCID: PMC6688519.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    40. Can Metabolic Pathways Be Therapeutic Targets in Rheumatoid Arthritis? J Clin Med. 2019 May 27; 8(5). Sanchez-Lopez E, Cheng A, Guma M. PMID: 31137815; PMCID: PMC6572063.
      View in: PubMed   Mentions: 20  
    41. Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut. Front Immunol. 2019; 10:1094. Garcia-Carbonell R, Yao SJ, Das S, Guma M. PMID: 31164887; PMCID: PMC6536010.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    42. Pro- and anti-inflammatory eicosanoids in psoriatic arthritis. Metabolomics. 2019 04 19; 15(4):65. Coras R, Kavanaugh A, Boyd T, Huynh Q, Pedersen B, Armando AM, Dahlberg-Wright S, Marsal S, Jain M, Paravar T, Quehenberger O, Guma M. PMID: 31004236; PMCID: PMC6533065.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    43. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metab. 2019 06 04; 29(6):1350-1362.e7. Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. PMID: 30982734; PMCID: PMC6675591.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    44. Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis. Clin Exp Rheumatol. 2019 May-Jun; 37(3):481-484. Coras R, Kavanaugh A, Boyd T, Huynh D, Lagerborg KA, Xu YJ, Rosenthal SB, Jain M, Guma M. PMID: 30620278; PMCID: PMC6529247.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    45. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):E9192-E9200. Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M. PMID: 30209212; PMCID: PMC6166836.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    46. Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis. Arthritis Res Ther. 2018 08 03; 20(1):164. Narasimhan R, Coras R, Rosenthal SB, Sweeney SR, Lodi A, Tiziani S, Boyle D, Kavanaugh A, Guma M. PMID: 30075744; PMCID: PMC6091066.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    47. Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis. Ann Rheum Dis. 2018 11; 77(11):1636-1643. Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M. PMID: 30061164; PMCID: PMC6328432.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    48. Liquid biopsies to guide therapeutic decisions in rheumatoid arthritis. Transl Res. 2018 11; 201:1-12. Coras R, Narasimhan R, Guma M. PMID: 30092207; PMCID: PMC6309446.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. Disease-Triggered Drug Release Effectively Prevents Acute Inflammatory Flare-Ups, Achieving Reduced Dosing. Small. 2018 08; 14(32):e1800703. Stubelius A, Sheng W, Lee S, Olejniczak J, Guma M, Almutairi A. PMID: 30009516; PMCID: PMC6165597.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 07; 70(7):984-999. Falconer J, Murphy AN, Young SP, Clark AR, Tiziani S, Guma M, Buckley CD. PMID: 29579371; PMCID: PMC6019623.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    51. Granulomatous fasciitis followed by morphea profunda: Is granulomatous fasciitis part of a spectrum of deep morphea? A case report and review of the literature. Clin Case Rep. 2018 Aug; 6(8):1412-1417. Christensen A, Di Loreto C, Smitaman E, Paravar T, Jones KA, Guma M. PMID: 30147873; PMCID: PMC6098999.
      View in: PubMed   Mentions: 1  
    52. Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent. Arthritis Rheumatol. 2018 01; 70(1):69-79. Friedman B, Whitney MA, Savariar EN, Caneda C, Steinbach P, Xiong Q, Hingorani DV, Crisp J, Adams SR, Kenner M, Lippert CN, Nguyen QT, Guma M, Tsien RY, Corr M. PMID: 29164814; PMCID: PMC5745304.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    53. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2017 05 31; 19(1):110. Bustamante MF, Garcia-Carbonell R, Whisenant KD, Guma M. PMID: 28569176; PMCID: PMC5452638.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    54. Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment. Birth Defects Res. 2017 Jul 03; 109(11):809-815. Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD. PMID: 28402073; PMCID: PMC5839165.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    55. Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast. Biomaterials. 2017 07; 133:119-131. Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A. PMID: 28433935; PMCID: PMC5704950.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    56. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open. 2016; 2(2):e000289. Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. PMID: 27651926; PMCID: PMC5013418.
      View in: PubMed   Mentions: 22  
    57. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 07; 68(7):1614-26. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. PMID: 26815411; PMCID: PMC4963240.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    58. Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol. 2016 May; 12(5):269-81. Guma M, Tiziani S, Firestein GS. PMID: 26935283; PMCID: PMC4963238.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    59. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. PMID: 26792803; PMCID: PMC4761524.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    60. AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. PLoS One. 2015; 10(10):e0140452. Guma M, Wang Y, Viollet B, Liu-Bryan R. PMID: 26474486; PMCID: PMC4608670.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    61. Analysis of NF-κB activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. Shaked H, Guma M, Karin M. PMID: 25736774.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    62. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. PMID: 25274633; PMCID: PMC4382461.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    63. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. PMID: 23341606; PMCID: PMC3568328.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    64. c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. Open Rheumatol J. 2012; 6:220-31. Guma M, Firestein GS. PMID: 23028407; PMCID: PMC3460413.
      View in: PubMed   Mentions: 23  
    65. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. PMID: 22488549; PMCID: PMC3397277.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    66. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. PMID: 22893683; PMCID: PMC3435160.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    67. IgG4-related diseases. Best Pract Res Clin Rheumatol. 2012 Aug; 26(4):425-38. Guma M, Firestein GS. PMID: 23040358.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    68. Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. PMID: 21825016; PMCID: PMC3171091.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    69. Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization. J Leukoc Biol. 2011 Oct; 90(4):717-26. Romo N, Magri G, Muntasell A, Heredia G, Baía D, Angulo A, Guma M, López-Botet M. PMID: 21742939.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    70. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. PMID: 21305529; PMCID: PMC3106119.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    71. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. PMID: 21173249; PMCID: PMC3017162.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    72. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. PMID: 21135226; PMCID: PMC3009768.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    73. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. PMID: 19950258; PMCID: PMC2847793.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    74. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784; PMCID: PMC2688966.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    75. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192; PMCID: PMC2669289.
      View in: PubMed   Mentions: 684     Fields:    Translation:AnimalsCells
    76. CD4+ lymphocytopenia in systemic lupus erythematosus. Ann Intern Med. 1994 Jan 15; 120(2):168-9. Guma M, Krakauer R. PMID: 8256983.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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