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    Monica Guma

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0663
    CA La Jolla 92093
    Phone858-822-6523
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      Collapse Research 
      Collapse Research Activities and Funding
      Choline metabolites as biomarkers in rheumatoid arthritis
      NIH R03AR068094Mar 1, 2015 - Jan 31, 2018
      Role: Principal Investigator
      Choline kinase: a novel target for rheumatoid arthritis
      NIH K08AR064834Sep 1, 2013 - Aug 31, 2018
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bustamante MF, Garcia-Carbonell R, Whisenant KD, Guma M. Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 2017 May 31; 19(1):110. PMID: 28569176.
        View in: PubMed
      2. Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD. Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment. Birth Defects Res. 2017 Jul 03; 109(11):809-815. PMID: 28402073.
        View in: PubMed
      3. Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A. Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast. Biomaterials. 2017 Jul; 133:119-131. PMID: 28433935.
        View in: PubMed
      4. Sweeney SR, Kavanaugh A, Lodi A, Wang B, Boyle D, Tiziani S, Guma M. Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. RMD Open. 2016; 2(2):e000289. PMID: 27651926; PMCID: PMC5013418.
      5. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 Jul; 68(7):1614-26. PMID: 26815411; PMCID: PMC4963240.
      6. Guma M, Tiziani S, Firestein GS. Metabolomics in rheumatic diseases: desperately seeking biomarkers. Nat Rev Rheumatol. 2016 May; 12(5):269-81. PMID: 26935283; PMCID: PMC4963238.
      7. Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38a-Dependent Restraint of NF-?B Signaling. J Immunol. 2016 Mar 01; 196(5):2368-76. PMID: 26792803; PMCID: PMC4761524 [Available on 03/01/17].
      8. Guma M, Wang Y, Viollet B, Liu-Bryan R. AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. PLoS One. 2015; 10(10):e0140452. PMID: 26474486; PMCID: PMC4608670.
      9. Shaked H, Guma M, Karin M. Analysis of NF-?B activation in mouse intestinal epithelial cells. Methods Mol Biol. 2015; 1280:593-606. PMID: 25736774.
        View in: PubMed
      10. Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS. Choline kinase inhibition in rheumatoid arthritis. Ann Rheum Dis. 2015 Jul; 74(7):1399-407. PMID: 25274633; PMCID: PMC4382461.
      11. Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2377-82. PMID: 23341606; PMCID: PMC3568328.
      12. Guma M, Firestein GS. c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. Open Rheumatol J. 2012; 6:220-31. PMID: 23028407; PMCID: PMC3460413.
      13. Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum. 2012 Sep; 64(9):2887-95. PMID: 22488549; PMCID: PMC3397277.
      14. Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-?B activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14007-12. PMID: 22893683; PMCID: PMC3435160.
      15. Guma M, Firestein GS. IgG4-related diseases. Best Pract Res Clin Rheumatol. 2012 Aug; 26(4):425-38. PMID: 23040358.
        View in: PubMed
      16. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. PMID: 21825016; PMCID: PMC3171091.
      17. Romo N, Magri G, Muntasell A, Heredia G, Baía D, Angulo A, Guma M, López-Botet M. Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization. J Leukoc Biol. 2011 Oct; 90(4):717-26. PMID: 21742939.
        View in: PubMed
      18. Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011 Jun; 63(6):1603-12. PMID: 21305529; PMCID: PMC3106119.
      19. Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):308-13. PMID: 21173249; PMCID: PMC3017162.
      20. Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22122-7. PMID: 21135226; PMCID: PMC3009768.
      21. Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M. Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009 Dec; 60(12):3642-50. PMID: 19950258; PMCID: PMC2847793.
      22. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. PMID: 19433784; PMCID: PMC2688966.
      23. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. PMID: 18432192; PMCID: PMC2669289.