Sharon Reed

InstitutionUniversity of California San Diego
Address9500 Gilman Drive #0612
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Phase IIa Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa
    NIH/NIAID U01AI110435May 5, 2015 - Apr 30, 2019
    Role: Principal Investigator
    Planning Grant for the Efficacy of Auranofin for the Treatment of Amebiasis
    NIH/NIAID R34AI098633Aug 24, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Novel Therapeutics for Class B Protozoa
    NIH/NIAID U01AI077822May 15, 2008 - Apr 30, 2014
    Role: Principal Investigator
    Genetic Manipulation of Entamoeba Virulence
    NIH/NIAID R01AI049531Sep 30, 2001 - May 31, 2007
    Role: Principal Investigator
    NIH/NIAID R01AI041903Aug 1, 1998 - May 31, 2003
    Role: Principal Investigator
    NIH/NIAID R21AI028035Jul 1, 1990 - Sep 29, 2001
    Role: Principal Investigator
    NIH/NIAID R01AI028035Jul 1, 1990 - Mar 31, 2000
    Role: Principal Investigator
    NIH P01DK035108Apr 1, 1985 - Jun 30, 2014
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 Aug; 12(8):e0006512. PMID: 30138453.
      View in: PubMed
    2. Jenks JD, Reed SL, Seidel D, Koehler P, Cornely OA, Mehta SR, Hoenigl M. Rare Mold Infections Caused by Mucorales, Lomentospora Prolificans and Fusarium, San Diego: The Role of Antifungal Combination Therapy. Int J Antimicrob Agents. 2018 Aug 09. PMID: 30099056.
      View in: PubMed
    3. Meyers L, Ginocchio CC, Faucett AN, Nolte FS, Gesteland PH, Leber A, Janowiak D, Donovan V, Dien Bard J, Spitzer S, Stellrecht KA, Salimnia H, Selvarangan R, Juretschko S, Daly JA, Wallentine JC, Lindsey K, Moore F, Reed SL, Aguero-Rosenfeld M, Fey PD, Storch GA, Melnick SJ, Robinson CC, Meredith JF, Cook CV, Nelson RK, Jones JD, Scarpino SV, Althouse BM, Ririe KM, Malin BA, Poritz MA. Automated Real-Time Collection of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology. JMIR Public Health Surveill. 2018 Jul 06; 4(3):e59. PMID: 29980501.
      View in: PubMed
    4. Reed SL, McKerrow JH. Why Funding for Neglected Tropical Diseases Should be a Global Priority. Clin Infect Dis. 2018 Apr 24. PMID: 29688342.
      View in: PubMed
    5. Chaparro JD, Cheng T, Tran UP, Andrade RM, Brenner SBT, Hwang G, Cohn S, Hirata K, McKerrow JH, Reed SL. Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis. PLoS One. 2018; 13(3):e0193982. PMID: 29565998.
      View in: PubMed
    6. Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. J Infect Dis. 2017 Dec 19; 216(12):1655-1666. PMID: 29029244.
      View in: PubMed
    7. Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T. Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection. Antimicrob Agents Chemother. 2017 Oct; 61(10). PMID: 28807909.
      View in: PubMed
    8. Krauth DS, Stone-Garza KK, Amaro DE, Reed SL, Katsivas TF. Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. Clin Case Rep. 2017 Oct; 5(10):1561-1564. PMID: 29026544.
      View in: PubMed
    9. Osorio G, Hoenigl M, Quartarolo J, Barger K, Morris SR, Reed SL, Lee J, Little SJ. Evaluation of opt-out inpatient HIV screening at an urban teaching hospital. AIDS Care. 2017 08; 29(8):1014-1018. PMID: 28114789.
      View in: PubMed
    10. Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent. Antimicrob Agents Chemother. 2017 01; 61(1). PMID: 27821451.
      View in: PubMed
    11. Liao X, Reed SL, Lin GY. Immunostaining Detection of Cytomegalovirus in Gastrointestinal Biopsies: Clinicopathological Correlation at a Large Academic Health System. Gastroenterology Res. 2016 Dec; 9(6):92-98. PMID: 28058077.
      View in: PubMed
    12. Amaro DE, Cowell A, Tuohy MJ, Procop GW, Morhaime J, Reed SL. Cerebral Paragonimiasis Presenting with Sudden Death. Am J Trop Med Hyg. 2016 Dec 07; 95(6):1424-1427. PMID: 27928089.
      View in: PubMed
    13. Schaefer G, Campbell W, Jenks J, Beesley C, Katsivas T, Hoffmaster A, Mehta SR, Reed S. Persistent Bacillus cereus Bacteremia in 3 Persons Who Inject Drugs, San Diego, California, USA. Emerg Infect Dis. 2016 09; 22(9):1621-3. PMID: 27533890; PMCID: PMC4994347.
    14. Leber AL, Everhart K, Balada-Llasat JM, Cullison J, Daly J, Holt S, Lephart P, Salimnia H, Schreckenberger PC, DesJarlais S, Reed SL, Chapin KC, LeBlanc L, Johnson JK, Soliven NL, Carroll KC, Miller JA, Dien Bard J, Mestas J, Bankowski M, Enomoto T, Hemmert AC, Bourzac KM. Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens. J Clin Microbiol. 2016 09; 54(9):2251-61. PMID: 27335149; PMCID: PMC5005480 [Available on 03/01/17].
    15. Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. J Struct Biol. 2016 May; 194(2):180-90. PMID: 26876147; PMCID: PMC5003402 [Available on 05/01/17].
    16. Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. ACS Med Chem Lett. 2016 Jan 14; 7(1):77-82. PMID: 26819670; PMCID: PMC4716606 [Available on 01/14/17].
    17. Andrade RM, Reed SL. New drug target in protozoan parasites: the role of thioredoxin reductase. Front Microbiol. 2015; 6:975. PMID: 26483758; PMCID: PMC4588103.
    18. Andrade RM, Chaparro JD, Capparelli E, Reed SL. Auranofin is highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis. PLoS Negl Trop Dis. 2014; 8(7):e2973. PMID: 25079790; PMCID: PMC4117455.
    19. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. PMID: 24820073; PMCID: PMC4068574.
    20. Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother. 2013 May; 57(5):2029-35. PMID: 23403423; PMCID: PMC3632933.
    21. Debnath A, Ndao M, Reed SL. Reprofiled drug targets ancient protozoans: drug discovery for parasitic diarrheal diseases. Gut Microbes. 2013 Jan-Feb; 4(1):66-71. PMID: 23137963; PMCID: PMC3555889.
    22. Aslam S, Jenne K, Reed S, Ghannoum M, Mehta R, Darouiche R. N-acetylcysteine lock solution prevents catheter-associated bacteremia in rabbits. Int J Artif Organs. 2012 Oct; 35(10):893-7. PMID: 23065881; PMCID: PMC3751799.
    23. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. PMID: 22610278; PMCID: PMC3411919.
    24. Jantscher-Krenn E, Lauwaet T, Bliss LA, Reed SL, Gillin FD, Bode L. Human milk oligosaccharides reduce Entamoeba histolytica attachment and cytotoxicity in vitro. Br J Nutr. 2012 Nov 28; 108(10):1839-46. PMID: 22264879.
      View in: PubMed
    25. Cobo ER, Reed SL, Corbeil LB. Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection. Int J Antimicrob Agents. 2012 Mar; 39(3):259-62. PMID: 22104282; PMCID: PMC3279618.
    26. Cobo ER, He C, Hirata K, Hwang G, Tran U, Eckmann L, Gallo RL, Reed SL. Entamoeba histolytica induces intestinal cathelicidins but is resistant to cathelicidin-mediated killing. Infect Immun. 2012 Jan; 80(1):143-9. PMID: 22083705; PMCID: PMC3255679.
    27. Reed SL, Mamo G, Gossa E, Jasura M, Getahun M, Lemma E, Mathews C, McCutchan JA. Improved tuberculosis smear detection in resource-limited settings: Combined bleach concentration and LED fluorescence microscopy. Int Health. 2011 Sep; 3(3):160-4. PMID: 24038365.
      View in: PubMed
    28. Lochhead MJ, Todorof K, Delaney M, Ives JT, Greef C, Moll K, Rowley K, Vogel K, Myatt C, Zhang XQ, Logan C, Benson C, Reed S, Schooley RT. Rapid multiplexed immunoassay for simultaneous serodiagnosis of HIV-1 and coinfections. J Clin Microbiol. 2011 Oct; 49(10):3584-90. PMID: 21865431; PMCID: PMC3187301.
    29. He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11; 285(24):18516-27. PMID: 20378535; PMCID: PMC2881777.
    30. Lu Q, Zhang XQ, Pond SL, Reed S, Schooley RT, Liu YT. Detection in 2009 of the swine origin influenza A (H1N1) virus by a subtyping microarray. J Clin Microbiol. 2009 Sep; 47(9):3060-1. PMID: 19605579; PMCID: PMC2738120.
    31. Schuster FL, Yagi S, Gavali S, Michelson D, Raghavan R, Blomquist I, Glastonbury C, Bollen AW, Scharnhorst D, Reed SL, Kuriyama S, Visvesvara GS, Glaser CA. Under the radar: balamuthia amebic encephalitis. Clin Infect Dis. 2009 Apr 01; 48(7):879-87. PMID: 19236272.
      View in: PubMed
    32. Brodine SK, Thomas A, Huang R, Harbertson J, Mehta S, Leake J, Nutman T, Moser K, Wolf J, Ramanathan R, Burbelo P, Nou J, Wilkins P, Reed SL. Community based parasitic screening and treatment of Sudanese refugees: application and assessment of Centers for Disease Control guidelines. Am J Trop Med Hyg. 2009 Mar; 80(3):425-30. PMID: 19270293.
      View in: PubMed
    33. Huang R, Que X, Hirata K, Brinen LS, Lee JH, Hansell E, Engel J, Sajid M, Reed S. The cathepsin L of Toxoplasma gondii (TgCPL) and its endogenous macromolecular inhibitor, toxostatin. Mol Biochem Parasitol. 2009 Mar; 164(1):86-94. PMID: 19111576; PMCID: PMC2663568.
    34. Margolis DA, Burns J, Reed SL, Ginsberg MM, O'Grady TC, Vinetz JM. Septicemic plague in a community hospital in California. Am J Trop Med Hyg. 2008 Jun; 78(6):868-71. PMID: 18541761; PMCID: PMC2746638.
    35. Broderick KE, Chan A, Balasubramanian M, Feala J, Reed SL, Panda M, Sharma VS, Pilz RB, Bigby TD, Boss GR. Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster. J Infect Dis. 2008 Feb 01; 197(3):457-64. PMID: 18199034.
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    36. Doyle PS, Sajid M, O'Brien T, Dubois K, Engel JC, Mackey ZB, Reed S. Drugs targeting parasite lysosomes. Curr Pharm Des. 2008; 14(9):889-900. PMID: 18473838.
      View in: PubMed
    37. Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model. Eukaryot Cell. 2007 Jul; 6(7):1130-6. PMID: 17513563; PMCID: PMC1951106.
    38. Cachay E, Mathews WC, Reed SL, Swancutt MA, Fierer J. Gonococcal meningitis diagnosed by DNA amplification: case report and review of the literature. AIDS Patient Care STDS. 2007 Jan; 21(1):4-8. PMID: 17263653.
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    39. Que X, Engel JC, Ferguson D, Wunderlich A, Tomavo S, Reed SL. Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii. J Biol Chem. 2007 Feb 16; 282(7):4994-5003. PMID: 17164247.
      View in: PubMed
    40. Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Exp Parasitol. 2007 Feb; 115(2):192-9. PMID: 16987516.
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    41. Shimizu C, Shike H, Baker SC, Garcia F, van der Hoek L, Kuijpers TW, Reed SL, Rowley AH, Shulman ST, Talbot HK, Williams JV, Burns JC. Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. J Infect Dis. 2005 Nov 15; 192(10):1767-71. PMID: 16235175; PMCID: PMC2888540.
    42. Choi MH, Sajed D, Poole L, Hirata K, Herdman S, Torian BE, Reed SL. An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack. Mol Biochem Parasitol. 2005 Sep; 143(1):80-9. PMID: 15996766.
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    43. Agron PG, Reed SL, Engel JN. An essential, putative MEK kinase of Leishmania major. Mol Biochem Parasitol. 2005 Jul; 142(1):121-5. PMID: 15878208.
      View in: PubMed
    44. Que X, Wunderlich A, Joiner KA, Reed SL. Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis. Infect Immun. 2004 May; 72(5):2915-21. PMID: 15102804; PMCID: PMC387868.
    45. Hughes MA, Lee CW, Holm CF, Ghosh S, Mills A, Lockhart LA, Reed SL, Mann BJ. Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein. Mol Biochem Parasitol. 2003 Apr 03; 127(2):113-20. PMID: 12672520.
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    46. Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infect Immun. 2003 Mar; 71(3):1274-80. PMID: 12595442; PMCID: PMC148873.
    47. Que X, Ngo H, Lawton J, Gray M, Liu Q, Engel J, Brinen L, Ghosh P, Joiner KA, Reed SL. The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing. J Biol Chem. 2002 Jul 12; 277(28):25791-7. PMID: 12000756.
      View in: PubMed
    48. Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol. 2002 Jan; 119(1):23-32. PMID: 11755183.
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